Showing toxin card for Acrolein (T3D0037)

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Version	1.0
Creation Date	2009-03-06 18:57:58
Update Date	2010-03-18 21:52:16
Accession Number	T3D0037
Name	Acrolein
Compound Type	Aldehyde Industrial Precursor/Intermediate Organic Compound
Description	Acrolein is the simplest unsaturated aldehyde. It is produced widely via the oxidation of propene but is most often immediately reacted with other products due to its instability and toxicity. Acrolein is used as a pesticide to control algae, weeds, bacteria, and mollusks. It is also used to make other chemicals. Small amounts of acrolein can be formed when trees, tobacco, other plants, gasoline, and oil are burned. (R224, R225)
Synonyms	2 Propenal 2-Propen-1-one 2-Propenal (Acrylaldehyde) 2-Propenal homopolymer 2-Propenaldehyde Acquinite Acraldehyde Acraldehydeacroleina Acraldehydeacroleina(italian) Acrolein Acrolein inhibited Acroleina [italian] Acrylaldehyd [german] Acrylaldehyde Acrylic aldehyde Akrolein [czech] Akroleina [polish] Aldehyde acrylique Aldehyde acrylique [french] Acrylic Aldehyde Allyl Aldehyde Ethylene Aldehyde Aldeide acrilica [italian] Allyl aldehyde Aqualin Aqualine Biocide Crolean Ethylene aldehyde MagnAcide Papite Polyacrolein Prop-2-en-1-al Propenal [czech] Propenaldehyde Propylene aldehyde Slimicide Trans-acrolein prop-2-en-1-al prop-2-enal
Chemical IUPAC Name	prop-2-enal
Chemical Formula	C₃H₄O
Chemical Structure
CAS Registry Number	107-02-8
InChI Identifier	InChI=1S/C3H4O/c1-2-3-4/h2-3H,1H2
InChI Key	InChIKey=HGINCPLSRVDWNT-UHFFFAOYSA-N
PubChem Compound ID	7847
KEGG ID	C01471
UniProt ID	Not Available
OMIM ID	Not Available
ChEBI ID	15368
BioCyc ID	T-2-NONENAL-CMPD
SuperToxic ID	Not Available
CTD ID	D000171
Stitch ID	Acrolein
DrugBank ID	Not Available
PDB ID	Not Available
ACToR ID	24
Wikipedia Link	Not Available
Monoisotopic Mass	56.026215
MOL File	Show
PDB File	Show
SDF File	Show
SMILES	C=CC=O
Appearance	Not Available
Melting Point	-87.7 °C
Solubility	212 mg/mL at 25 °C [SEIDELL,A (1941)]
Predicted LogP	0.3743
Route of Exposure	Oral (R224) ; inhalation (R224) ; dermal (R224)
Mechanism of Action	Acrolein rapidly and irreversibly binds to lysine moieties and sulfhydryl groups found on many cellular molecules forming thiol ethers. By this mechanism acrolein can bind to messenger compounds to produce direct cytotoxic effects or secondary effects from interrupted cell signaling pathways. Perturbation of inflammatory responses in bronchial epithelial cells was demonstrated by direct action of acrolein on the inhibitor of nuclear factor kappa-B (I?B) kinase, which inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) transcription factor and suppresses interleukin 8 (IL-8) production. Rapid binding of acrolein to neural receptors in the corneal and nasal mucosa results in rapid depolarization of the associated neurons to produce ocular and nasal irritation. Acrolein also binds rapidly to glutathione, which may be inhibitory to the enzyme glutathione peroxidase and result in a lower level of cellular protection against oxygen radical toxicity. Further, the adduction of glutathione generates GS-propionaldehyde, which produces oxygen and possibly hydroxy radicals via cytosolic aldehyde dehydrogenase. Acrolein inhibits thioredoxin and thioredoxin reductase, which disrupts the cellular thiol redox balance necessary for cell survival. It interferes with normal reverse cholesterol transport by high density lipoprotein (HDL) by modifying specific sites in apolipoprotein A-I. Acrolein also inhibits aldehyde dehydrogenases and activates the transient receptor potential cation channel. (R224, R226, R227, R228)
Metabolism	Acrolein can be absorbed though oral, inhalation, or dermal routes. In the liver and kidneys, acrolein forms conjugates with glutathione, cysteine, N-acetylcysteine, and/or thioredoxin. Acrolein can also be transformed into acrylic acid by liver cytosol or microsomes, or it can be oxidized to glycidaldehyde by lung or liver microsomes. Acrolein metabolites are excreted in the urine. (R224)
Toxicity Values	LC50: 130 ppm over 30 minutes (Inhalation, Rat) (R286) LD50: 562 mg/kg (Dermal, Rabbit) (R287) LD50: 46 mg/kg (Oral, Rat) (R287) LD50: 30 mg/kg (Subcutaneous, Rat) (R287)
Lethal Dose	10 ppm for an adult human. (R270)
Carcinogenicity (IARC Classification)	3, not classifiable as to its carcinogenicity to humans. (R264)
Uses/Sources	Acrolein is used as a pesticide to control algae, weeds, bacteria, and mollusks. It is also used to make other chemicals, such as polyester resin, polyurethane, propylene glycol, acrylic acid, acrylonitrile, and glycerol. Small amounts of acrolein can be formed when trees, tobacco, other plants, gasoline, and oil are burned. (R224)
Minimum Risk Level	Acute Inhalation: 0.003 ppm (R260) Intermediate Inhalation: 0.00004 ppm (R260) Intermediate Oral: 2 mg/kg/day (R260)
Health Effects	Acrolein is a severe pulmonary irritant and lachrymatory agent. Breathing large amounts of acrolein damages the lungs and could cause death. (R224, R225)
Symptoms	Ingestion of acrolein causes stomach irritation, vomiting, stomach ulcers and bleeding. Breathing acrolein may cause eye watering, burning of the nose and throat and a decreased breathing rate. (R224)
Treatment	Not Available
General References	R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ] R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. R270 - HSDB: Hazardous Substances Data Bank. National Library of Medicine (2001). R226 - Myers CR, Myers JM: The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells. Toxicology. 2009 Mar 4;257(1-2):95-104. Epub 2008 Dec 24. [PubMed ] R228 - Shao B, Fu X, McDonald TO, Green PS, Uchida K, O'Brien KD, Oram JF, Heinecke JW: Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. J Biol Chem. 2005 Oct 28;280(43):36386-96. Epub 2005 Aug 25. [PubMed ] R260 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). R225 - Wikipedia. Acrolein. Last Updated 14 April 2009. R286 - Clayton GD and Clayton FE (eds) (1993-1994). Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc. R224 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for acrolein. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). R287 - ITII (1988). Toxic and Hazardous Industrial Chemicals Safety Manual. Tokyo, Japan: The International Technical Information Institute.
Targets	Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibitor of nuclear factor kappa-B kinase subunit epsilon Thioredoxin Thioredoxin, mitochondrial Thioredoxin reductase 1, cytoplasmic Thioredoxin reductase 2, mitochondrial Thioredoxin reductase 3 Apolipoprotein A-I Aldehyde dehydrogenase family 1 member A3 Fatty aldehyde dehydrogenase Aldehyde dehydrogenase, dimeric NADP-preferring Retinal dehydrogenase 1 Retinal dehydrogenase 2 Aldehyde dehydrogenase family 3 member B1 Aldehyde dehydrogenase family 3 member B2 Aldehyde dehydrogenase X, mitochondrial 10-formyltetrahydrofolate dehydrogenase Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2 Transient receptor potential cation channel subfamily A member 1 Succinate-semialdehyde dehydrogenase, mitochondrial NF-kappa-B essential modulator

Target 1 [top]

Target 1 ID

314

Target 1 Name

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Target 1 Mechanism of Action

Perturbation of inflammatory responses in bronchial epithelial cells was demonstrated by direct action of acrolein on the inhibitor of nuclear factor kappa-B (I?B) kinase, which inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) transcription factor and suppresses interleukin 8 (IL-8) production. (R223)

Target 1 Description

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF- kappa-B-regulated promoters during inflammatory responses triggered by cytokines

Target 1 Synonyms

I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA

Target 1 Gene Name

CHUK

Target 1 Protein Sequence

>Inhibitor of nuclear factor kappa-B kinase subunit alpha

MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL
STIIHEANEEQGNSMMNLDWSWLTE

Target 1 Number of Residues

745

Target 1 Molecular Weight

84652.9

Target 1 Theoretical pI

6.72

Target 1 GO Classification

Function
protein serine/threonine kinase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity
Process
physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 1 General Function

Involved in ATP binding

Target 1 Pathways

Not Available

Target 1 Reactions

Not Available

Target 1 Signals

None

Target 1 Transmembrane Regions

None

Target 1 Essentiality

Non Essential

Target 1 Domain Function

PF00069:Pkinase

Target 1 GenBank ID Protein

Not Available

Target 1 UniProtKB ID

O15111

Target 1 Cellular Location

Cytoplasm. Nucleus

Target 1 Gene Sequence

Not Available

Target 1 GenBank Gene ID

Not Available

Target 1 GeneCard ID

CHUK

Target 1 GenAtlas ID

CHUK

Target 1 HGNC ID

HGNC:1974

Target 1 Chromosome Location

Chromosome:10

Target 1 Locus

10q24-q25

Target 1 SNPs

SNPJam Report Link Image

Target 1 Toxin References

R223 - Kaphalia BS, Ansari GA: Covalent binding of ethylene dibromide and its metabolites to albumin. Toxicol Lett. 1992 Sep;62(2-3):221-30. [PubMed ]

Target 1 General References

9244310; 9252186; 9346484; 9813230; 15164054; 8777433; 9751059; 9520446; 10485710

Target 2 [top]

Target 2 ID

315

Target 2 Name

Inhibitor of nuclear factor kappa-B kinase subunit beta

Target 2 Mechanism of Action

Target 2 Description

Target 2 Synonyms

I-kappa-B-kinase beta; IkBKB; IKK-beta; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB

Target 2 Gene Name

IKBKB

Target 2 Protein Sequence

>Inhibitor of nuclear factor kappa-B kinase subunit beta

MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS

Target 2 Number of Residues

756

Target 2 Molecular Weight

86563.2

Target 2 Theoretical pI

5.53

Target 2 GO Classification

Function
protein serine/threonine kinase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity
Process
physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 2 General Function

Involved in ATP binding

Target 2 Pathways

Not Available

Target 2 Reactions

Not Available

Target 2 Signals

None

Target 2 Transmembrane Regions

None

Target 2 Essentiality

Non Essential

Target 2 Domain Function

PF00069:Pkinase PF00240:ubiquitin

Target 2 GenBank ID Protein

Not Available

Target 2 UniProtKB ID

O14920

Target 2 Cellular Location

Cytoplasm

Target 2 Gene Sequence

Not Available

Target 2 GenBank Gene ID

Not Available

Target 2 GeneCard ID

IKBKB

Target 2 GenAtlas ID

IKBKB

Target 2 HGNC ID

HGNC:5960

Target 2 Chromosome Location

Not Available

Target 2 Locus

8p11.2

Target 2 SNPs

SNPJam Report Link Image

Target 2 Toxin References

R223 - Kaphalia BS, Ansari GA: Covalent binding of ethylene dibromide and its metabolites to albumin. Toxicol Lett. 1992 Sep;62(2-3):221-30. [PubMed ]

Target 2 General References

9346484; 9346485; 9813230; 9763654; 15489334; 9819420; 9751059; 10356400; 10195894

Target 3 [top]

Target 3 ID

316

Target 3 Name

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Target 3 Mechanism of Action

Target 3 Description

Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response

Target 3 Synonyms

I kappa-B kinase epsilon; IkBKE; IKK-epsilon; IKK-E; Inducible I kappa-B kinase; IKK-i

Target 3 Gene Name

IKBKE

Target 3 Protein Sequence

>Inhibitor of nuclear factor kappa-B kinase subunit epsilon

MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV

Target 3 Number of Residues

716

Target 3 Molecular Weight

80461.7

Target 3 Theoretical pI

7.90

Target 3 GO Classification

Function
protein serine/threonine kinase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity
Process
physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 3 General Function

Involved in ATP binding

Target 3 Pathways

Not Available

Target 3 Reactions

Not Available

Target 3 Signals

None

Target 3 Transmembrane Regions

None

Target 3 Essentiality

Non Essential

Target 3 Domain Function

PF00069:Pkinase

Target 3 GenBank ID Protein

Not Available

Target 3 UniProtKB ID

Q14164

Target 3 Cellular Location

Cytoplasm (Probable)

Target 3 Gene Sequence

Not Available

Target 3 GenBank Gene ID

Not Available

Target 3 GeneCard ID

IKBKE

Target 3 GenAtlas ID

IKBKE

Target 3 HGNC ID

HGNC:14552 Link Image

Target 3 Chromosome Location

Not Available

Target 3 Locus

1q32.1

Target 3 SNPs

SNPJam Report Link Image

Target 3 Toxin References

R223 - Kaphalia BS, Ansari GA: Covalent binding of ethylene dibromide and its metabolites to albumin. Toxicol Lett. 1992 Sep;62(2-3):221-30. [PubMed ]

Target 3 General References

10421793; 10882136; 8590280; 16710414; 15489334; 14560022; 14739303; 16281057; 16177806

Target 4 [top]

Target 4 ID

Target 4 Name

Thioredoxin

Target 4 Mechanism of Action

Acrolein inhibits thioredoxin, which disrupts the cellular thiol redox balance necessary for cell survival. (R226)

Target 4 Description

ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55)

Target 4 Synonyms

Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP

Target 4 Gene Name

TXN

Target 4 Protein Sequence

>Thioredoxin

MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD
DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV

Target 4 Number of Residues

105

Target 4 Molecular Weight

11737.4

Target 4 Theoretical pI

4.55

Target 4 GO Classification

Function
transporter activity electron transporter activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 4 General Function

Posttranslational modification, protein turnover, chaperones

Target 4 Pathways

Not Available

Target 4 Reactions

Not Available

Target 4 Signals

None

Target 4 Transmembrane Regions

None

Target 4 Essentiality

Non Essential

Target 4 Domain Function

PF00085:Thioredoxin

Target 4 GenBank ID Protein

Not Available

Target 4 UniProtKB ID

P10599

Target 4 Cellular Location

Cytoplasm

Target 4 Gene Sequence

>318 bp

TCGTCAGACTCCAGCAGCCAAGATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGA
AGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGG
GCCTTGCAAAATGATCAACCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGTGAT
ATTCCTTGAAGTAGATGTGGATGACTGTCAGGATGTTGCTTCAGAGTGTGAAGTCAAATG
CACGCCAACATTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAA
TAAGGAAAAGCTTGAAGC

Target 4 GenBank Gene ID

Not Available

Target 4 GeneCard ID

TXN

Target 4 GenAtlas ID

TXN

Target 4 HGNC ID

HGNC:12435 Link Image

Target 4 Chromosome Location

Not Available

Target 4 Locus

9q31

Target 4 SNPs

SNPJam Report Link Image

Target 4 Toxin References

R226 - Myers CR, Myers JM: The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells. Toxicology. 2009 Mar 4;257(1-2):95-104. Epub 2008 Dec 24. [PubMed ]

Target 4 General References

3170595; 2785919; 1874447; 14702039; 15164053

Target 5 [top]

Target 5 ID

317

Target 5 Name

Thioredoxin, mitochondrial

Target 5 Mechanism of Action

Acrolein inhibits thioredoxin, which disrupts the cellular thiol redox balance necessary for cell survival. (R226)

Target 5 Description

Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity

Target 5 Synonyms

Mt-Trx; MTRX; Thioredoxin-2

Target 5 Gene Name

TXN2

Target 5 Protein Sequence

>Thioredoxin, mitochondrial

MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLT
TFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDD
HTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG

Target 5 Number of Residues

166

Target 5 Molecular Weight

18383.2

Target 5 Theoretical pI

8.49

Target 5 GO Classification

Function
transporter activity electron transporter activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 5 General Function

Posttranslational modification, protein turnover, chaperones

Target 5 Pathways

Not Available

Target 5 Reactions

Not Available

Target 5 Signals

None

Target 5 Transmembrane Regions

None

Target 5 Essentiality

Non Essential

Target 5 Domain Function

PF00085:Thioredoxin

Target 5 GenBank ID Protein

Not Available

Target 5 UniProtKB ID

Q99757

Target 5 Cellular Location

Mitochondrion

Target 5 Gene Sequence

>501 bp

ATGGCTCAGCGACTTCTTCTGAGGAGGTTCCTGGCCTCTGTCATCTCCAGGAAGCCCTCT
CAGGGTCAGTGGCCACCCCTCACTTCCAGAGCCCTGCAGACCCCACAATGCAGTCCTGGT
GGCCTGACTGTAACACCCAACCCAGCCCGGACAATATACACCACGAGGATCTCCTTGACA
ACCTTTAATATCCAGGATGGACCTGACTTTCAAGACCGAGTGGTCAACAGTGAGACACCA
GTGGTTGTGGATTTCCACGCACAGTGGTGTGGACCCTGCAAGATCCTGGGGCCGAGGTTA
GAGAAGATGGTGGCCAAGCAGCACGGGAAGGTGGTGATGGCCAAGGTGGATATTGATGAC
CACACAGACCTCGCCATTGAGTATGAGGTGTCAGCGGTGCCCACTGTGCTGGCCATGAAG
AATGGGGACGTGGTGGACAAGTTTGTGGGCATCAAGGATGAGGATCAGTTGGAGGCCTTC
CTGAAGAAGCTGATTGGCTGA

Target 5 GenBank Gene ID

Not Available

Target 5 GeneCard ID

TXN2

Target 5 GenAtlas ID

TXN2

Target 5 HGNC ID

HGNC:17772 Link Image

Target 5 Chromosome Location

Chromosome:22

Target 5 Locus

22q13.1

Target 5 SNPs

SNPJam Report Link Image

Target 5 Toxin References

R226 - Myers CR, Myers JM: The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells. Toxicology. 2009 Mar 4;257(1-2):95-104. Epub 2008 Dec 24. [PubMed ]

Target 5 General References

12032145; 12080052; 15461802; 10591208; 15489334; 16195549

Target 6 [top]

Target 6 ID

171

Target 6 Name

Thioredoxin reductase 1, cytoplasmic

Target 6 Mechanism of Action

Acrolein inhibits thioredoxin reductase, which disrupts the cellular thiol redox balance necessary for cell survival. (R226)

Target 6 Description

Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid

Target 6 Synonyms

TR; Thioredoxin reductase TR1; KM-102-derived reductase-like factor; Gene associated with retinoid-IFN-induced mortality 12 protein; GRIM-12

Target 6 Gene Name

TXNRD1

Target 6 Protein Sequence

>Thioredoxin reductase 1, cytoplasmic

MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG

Target 6 Number of Residues

649

Target 6 Molecular Weight

70905.6

Target 6 Theoretical pI

7.42

Target 6 GO Classification

Function
oxidoreductase activity, acting on NADH or NADPH oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor disulfide oxidoreductase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding FAD binding catalytic activity oxidoreductase activity transporter activity electron transporter activity
Process
homeostasis cell homeostasis cell redox homeostasis physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell intracellular cytoplasm

Target 6 General Function

Energy production and conversion

Target 6 Pathways

Not Available

Target 6 Reactions

Not Available

Target 6 Signals

None

Target 6 Transmembrane Regions

None

Target 6 Essentiality

Non Essential

Target 6 Domain Function

PF00462:Glutaredoxin PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim

Target 6 GenBank ID Protein

Not Available

Target 6 UniProtKB ID

Q16881

Target 6 Cellular Location

Isoform 5:Cytoplasm

Target 6 Gene Sequence

Not Available

Target 6 GenBank Gene ID

Not Available

Target 6 GeneCard ID

TXNRD1

Target 6 GenAtlas ID

TXNRD1

Target 6 HGNC ID

HGNC:12437 Link Image

Target 6 Chromosome Location

Chromosome:12

Target 6 Locus

12q23-q24.1

Target 6 SNPs

SNPJam Report Link Image

Target 6 Toxin References

R226 - Myers CR, Myers JM: The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells. Toxicology. 2009 Mar 4;257(1-2):95-104. Epub 2008 Dec 24. [PubMed ]

Target 6 General References

7589432; 8999974; 9774665; 14980707; 15489334

Target 7 [top]

Target 7 ID

229

Target 7 Name

Thioredoxin reductase 2, mitochondrial

Target 7 Mechanism of Action

Acrolein inhibits thioredoxin reductase, which disrupts the cellular thiol redox balance necessary for cell survival. (R226)

Target 7 Description

Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling

Target 7 Synonyms

Thioredoxin reductase TR3; TR-beta; Selenoprotein Z; SelZ

Target 7 Gene Name

TXNRD2

Target 7 Protein Sequence

>Thioredoxin reductase 2, mitochondrial

MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQ
LGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLS
ADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGI
GLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST
TGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDV
VEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHG
QEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALG
IKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPTVTGCUG

Target 7 Number of Residues

524

Target 7 Molecular Weight

56506.3

Target 7 Theoretical pI

7.55

Target 7 GO Classification

Function
oxidoreductase activity, acting on NADH or NADPH oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor disulfide oxidoreductase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding FAD binding catalytic activity oxidoreductase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell intracellular cytoplasm

Target 7 General Function

Energy production and conversion

Target 7 Pathways

Not Available

Target 7 Reactions

Not Available

Target 7 Signals

None

Target 7 Transmembrane Regions

None

Target 7 Essentiality

Non Essential

Target 7 Domain Function

PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim

Target 7 GenBank ID Protein

Not Available

Target 7 UniProtKB ID

Q9NNW7

Target 7 Cellular Location

Mitochondrion

Target 7 Gene Sequence

>1575 bp

ATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAG
GCCGTGGCGGGCGGGGTGCGGGGCGCGGCGCGGGGCGCAGCAGCAGGTCAGCGGGACTAT
GATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAG
CTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGG
GGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCG
GCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCC
GTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAAC
TGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGC
TTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCA
GCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGT
GCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAA
ACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATT
GGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATG
TCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCC
CCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACC
ACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGGTCGAGTCCCA
GACACCAGAAGTCTGAATTTGGAGAAGGCTGGGGTAGATACTAGCCCCGACACTCAGAAG
ATCCTGGTGGACTCCCGGGAAGCCACCTCTGTGCCCCACATCTACGCCATTGGTGACGTG
GTGGAGGGGCGGCCTGAGCTGACACCCATAGCGATCATGGCCGGGAGGCTCCTGGTGCAG
CGGCTCTTCGGCGGGTCCTCAGATCTGATGGACTACGACAATGTTCCCACGACCGTCTTC
ACCCCGCTGGAGTATGGCTGTGTGGGGCTGTCCGAGGAGGAGGCAGTGGCTCGCCACGGG
CAGGAGCATGTTGAGGTCTATCACGCCCATTATAAACCACTGGAGTTCACGGTGGCTGGA
CGAGATGCATCCCAGTGTTATGTAAAGATGGTGTGCCTGAGGGAGCCCCCACAGCTGGTG
CTGGGCCTGCATTTCCTTGGCCCCAACGCAGGCGAAGTTACTCAAGGATTTGCTCTGGGG
ATCAAGTGTGGGGCTTCCTATGCGCAGGTGATGCGGACCGTGGGTATCCATCCCACATGC
TCTGAGGAGGTAGTCAAGCTGCGCATCTCCAAGCGCTCAGGCCTGGACCCCACGGTGACA
GGCTGCTGAGGGTAA

Target 7 GenBank Gene ID

Not Available

Target 7 GeneCard ID

TXNRD2

Target 7 GenAtlas ID

TXNRD2

Target 7 HGNC ID

HGNC:18155 Link Image

Target 7 Chromosome Location

Chromosome:22

Target 7 Locus

22q11.21

Target 7 SNPs

SNPJam Report Link Image

Target 7 Toxin References

R226 - Myers CR, Myers JM: The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells. Toxicology. 2009 Mar 4;257(1-2):95-104. Epub 2008 Dec 24. [PubMed ]

Target 7 General References

10455115; 9923614; 10215850; 10608886; 10591208; 15489334; 11060283

Target 8 [top]

Target 8 ID

Target 8 Name

Thioredoxin reductase 3

Target 8 Mechanism of Action

Acrolein inhibits thioredoxin reductase, which disrupts the cellular thiol redox balance necessary for cell survival. (R226)

Target 8 Description

Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)

Target 8 Synonyms

Thioredoxin reductase TR2; Thioredoxin and glutathione reductase

Target 8 Gene Name

TXNRD3

Target 8 Protein Sequence

>Thioredoxin reductase 3

MGHVHRLVSGKRRMHLTSRPVASTHSPLILDMCPHLNNGPMTGCGRAGDPISHARGGAGG
RGERLPRGFARVVRVASEGSVRRPSGPVPAPQPPAFRFVSRPGRARSESETLERSPPQSP
GPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVV
IFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTVPNIFVNKVH
VGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVV
PSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRHNWETMTKAI
QNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERP
RYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILL
RGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYN
TVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPV
AIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTL
FWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLL
DDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG

Target 8 Number of Residues

754

Target 8 Molecular Weight

82463.9

Target 8 Theoretical pI

8.80

Target 8 GO Classification

Function
oxidoreductase activity, acting on NADH or NADPH oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor disulfide oxidoreductase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding FAD binding catalytic activity oxidoreductase activity transporter activity electron transporter activity
Process
homeostasis cell homeostasis cell redox homeostasis physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell intracellular cytoplasm

Target 8 General Function

Energy production and conversion

Target 8 Pathways

Not Available

Target 8 Reactions

Not Available

Target 8 Signals

None

Target 8 Transmembrane Regions

None

Target 8 Essentiality

Non Essential

Target 8 Domain Function

PF00462:Glutaredoxin PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim

Target 8 GenBank ID Protein

Not Available

Target 8 UniProtKB ID

Q86VQ6

Target 8 Cellular Location

Cytoplasm (By similarity). Nucleus (By similarity). Microsome (By similarity). Endoplasmic reticulum (By similarity)

Target 8 Gene Sequence

Not Available

Target 8 GenBank Gene ID

Not Available

Target 8 GeneCard ID

TXNRD3

Target 8 GenAtlas ID

TXNRD3

Target 8 HGNC ID

HGNC:20667 Link Image

Target 8 Chromosome Location

Not Available

Target 8 Locus

3q21.3

Target 8 SNPs

SNPJam Report Link Image

Target 8 Toxin References

R226 - Myers CR, Myers JM: The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells. Toxicology. 2009 Mar 4;257(1-2):95-104. Epub 2008 Dec 24. [PubMed ]

Target 8 General References

16641997; 15489334; 10455115; 18669648

Target 9 [top]

Target 9 ID

318

Target 9 Name

Apolipoprotein A-I

Target 9 Mechanism of Action

Acrolein interferes with normal reverse cholesterol transport by high density lipoprotein (HDL) by modifying specific sites in apolipoprotein A-I. (R228)

Target 9 Description

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility

Target 9 Synonyms

Apo-AI; ApoA-I; Apolipoprotein A-I(1-242)

Target 9 Gene Name

APOA1

Target 9 Protein Sequence

>Apolipoprotein A-I

MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS
ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK
VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV
DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ
GLLPVLESFKVSFLSALEEYTKKLNTQ

Target 9 Number of Residues

267

Target 9 Molecular Weight

30777.6

Target 9 Theoretical pI

5.50

Target 9 GO Classification

Function
binding lipid binding
Process
metabolism macromolecule metabolism protein metabolism cellular protein metabolism lipoprotein metabolism physiological process cellular physiological process transport lipid transport
Component
extracellular region

Target 9 General Function

Involved in apolipoprotein A-I receptor binding

Target 9 Pathways

Not Available

Target 9 Reactions

Not Available

Target 9 Signals

1-18

Target 9 Transmembrane Regions

None

Target 9 Essentiality

Non Essential

Target 9 Domain Function

PF01442:Apolipoprotein

Target 9 GenBank ID Protein

Not Available

Target 9 UniProtKB ID

P02647

Target 9 Cellular Location

Secreted

Target 9 Gene Sequence

>804 bp

ATGAAAGCTGCGGTGCTGACCTTGGCCGTGCTCTTCCTGACGGGGAGCCAGGCTCGGCAT
TTCTGGCAGCAAGATGAACCCCCCCAGAGCCCCTGGGATCGAGTGAAGGACCTGGCCACT
GTGTACGTGGATGTGCTCAAAGACAGCGGCAGAGACTATGTGTCCCAGTTTGAAGGCTCC
GCCTTGGGAAAACAGCTAAACCTAAAGCTCCTTGACAACTGGGACAGCGTGACCTCCACC
TTCAGCAAGCTGCGCGAACAGCTCGGCCCTGTGACCCAGGAGTTCTGGGATAACCTGGAA
AAGGAGACAGAGGGCCTGAGGCAGGAGATGAGCAAGGATCTGGAGGAGGTGAAGGCCAAG
GTGCAGCCCTACCTGGACGACTTCCAGAAGAAGTGGCAGGAGGAGATGGAGCTCTACCGC
CAGAAGGTGGAGCCGCTGCGCGCAGAGCTCCAAGAGGGCGCGCGCCAGAAGCTGCACGAG
CTGCAAGAGAAGCTGAGCCCACTGGGCGAGGAGATGCGCGACCGCGCGCGCGCCCATGTG
GACGCGCTGCGCACGCATCTGGCCCCCTACAGCGACGAGCTGCGCCAGCGCTTGGCCGCG
CGCCTTGAGGCTCTCAAGGAGAACGGCGGCGCCAGACTGGCCGAGTACCACGCCAAGGCC
ACCGAGCATCTGAGCACGCTCAGCGAGAAGGCCAAGCCCGCGCTCGAGGACCTCCGCCAA
GGCCTGCTGCCCGTGCTGGAGAGCTTCAAGGTCAGCTTCCTGAGCGCTCTCGAGGAGTAC
ACTAAGAAGCTCAACACCCAGTGA

Target 9 GenBank Gene ID

Not Available

Target 9 GeneCard ID

APOA1

Target 9 GenAtlas ID

APOA1

Target 9 HGNC ID

HGNC:600

Target 9 Chromosome Location

Chromosome:11

Target 9 Locus

11q23-q24

Target 9 SNPs

SNPJam Report Link Image

Target 9 Toxin References

R228 - Shao B, Fu X, McDonald TO, Green PS, Uchida K, O'Brien KD, Oram JF, Heinecke JW: Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. J Biol Chem. 2005 Oct 28;280(43):36386-96. Epub 2005 Aug 25. [PubMed ]

Target 9 General References

6406984; 6304641; 6413973; 6207999; 6328445; 6198645; 2995392; 3129297; 2673706; 15108119

Target 10 [top]

Target 10 ID

328

Target 10 Name

Aldehyde dehydrogenase family 1 member A3

Target 10 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 10 Description

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity)

Target 10 Synonyms

Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

Target 10 Gene Name

ALDH1A3

Target 10 Protein Sequence

>Aldehyde dehydrogenase family 1 member A3

MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

Target 10 Number of Residues

512

Target 10 Molecular Weight

56108.0

Target 10 Theoretical pI

7.29

Target 10 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 10 General Function

Energy production and conversion

Target 10 Pathways

Cofactor metabolism; retinol metabolism

Target 10 Reactions

Not Available

Target 10 Signals

None

Target 10 Transmembrane Regions

None

Target 10 Essentiality

Non Essential

Target 10 Domain Function

PF00171:Aldedh

Target 10 GenBank ID Protein

Not Available

Target 10 UniProtKB ID

P47895

Target 10 Cellular Location

Cytoplasm (By similarity)

Target 10 Gene Sequence

>1539 bp

ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

Target 10 GenBank Gene ID

Not Available

Target 10 GeneCard ID

ALDH1A3

Target 10 GenAtlas ID

ALDH1A3

Target 10 HGNC ID

HGNC:409

Target 10 Chromosome Location

Chromosome:15

Target 10 Locus

15q26.3

Target 10 SNPs

SNPJam Report Link Image

Target 10 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 10 General References

7698756; 15489334

Target 11 [top]

Target 11 ID

319

Target 11 Name

Fatty aldehyde dehydrogenase

Target 11 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 11 Description

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

Target 11 Synonyms

Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10; Microsomal aldehyde dehydrogenase

Target 11 Gene Name

ALDH3A2

Target 11 Protein Sequence

>Fatty aldehyde dehydrogenase

MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY

Target 11 Number of Residues

485

Target 11 Molecular Weight

54847.4

Target 11 Theoretical pI

7.99

Target 11 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 11 General Function

Energy production and conversion

Target 11 Pathways

Not Available

Target 11 Reactions

Not Available

Target 11 Signals

None

Target 11 Transmembrane Regions

464-480

Target 11 Essentiality

Non Essential

Target 11 Domain Function

PF00171:Aldedh

Target 11 GenBank ID Protein

Not Available

Target 11 UniProtKB ID

P51648

Target 11 Cellular Location

Endoplasmic reticulum membrane

Target 11 Gene Sequence

>1458 bp

ATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTG
CGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGAT
ATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAA
GTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACT
GCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAG
CCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAG
CCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGT
GAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTAT
ATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCAC
ATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCAT
CTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGT
GACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACC
TGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAG
ATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAA
AGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATA
GCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGAT
GTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTG
CCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCT
CTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGT
GGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGA
GGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCT
CATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATAT
CCTCCCAACAGCCAGTCAAAGGTGGATTGGGGGAAATTTTTTCTCTTGAAACGGTTCAAC
AAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTC
AAGGCAGAATATTACTGA

Target 11 GenBank Gene ID

Not Available

Target 11 GeneCard ID

ALDH3A2

Target 11 GenAtlas ID

ALDH3A2

Target 11 HGNC ID

HGNC:403

Target 11 Chromosome Location

Chromosome:17

Target 11 Locus

17p11.2

Target 11 SNPs

SNPJam Report Link Image

Target 11 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 11 General References

8528251; 9027499; 9070922; 15489334; 9254849; 9829906; 10577908; 10792573

Target 12 [top]

Target 12 ID

321

Target 12 Name

Aldehyde dehydrogenase, dimeric NADP-preferring

Target 12 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 12 Description

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

Target 12 Synonyms

Aldehyde dehydrogenase family 3 member A1; Aldehyde dehydrogenase 3; ALDHIII

Target 12 Gene Name

ALDH3A1

Target 12 Protein Sequence

>Aldehyde dehydrogenase, dimeric NADP-preferring

MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

Target 12 Number of Residues

453

Target 12 Molecular Weight

50378.6

Target 12 Theoretical pI

6.52

Target 12 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 12 General Function

Energy production and conversion

Target 12 Pathways

Not Available

Target 12 Reactions

Not Available

Target 12 Signals

None

Target 12 Transmembrane Regions

None

Target 12 Essentiality

Non Essential

Target 12 Domain Function

PF00171:Aldedh

Target 12 GenBank ID Protein

Not Available

Target 12 UniProtKB ID

P30838

Target 12 Cellular Location

Cytoplasm

Target 12 Gene Sequence

>1362 bp

ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

Target 12 GenBank Gene ID

Not Available

Target 12 GeneCard ID

ALDH3A1

Target 12 GenAtlas ID

ALDH3A1

Target 12 HGNC ID

HGNC:405

Target 12 Chromosome Location

Chromosome:17

Target 12 Locus

17p11.2

Target 12 SNPs

SNPJam Report Link Image

Target 12 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 12 General References

1737758; 8493892; 16625196; 15489334; 2037078; 1905102; 9250352

Target 13 [top]

Target 13 ID

322

Target 13 Name

Retinal dehydrogenase 1

Target 13 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 13 Description

Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity)

Target 13 Synonyms

RALDH 1; RalDH1; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; ALHDII; ALDH-E1

Target 13 Gene Name

ALDH1A1

Target 13 Protein Sequence

>Retinal dehydrogenase 1

MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV
DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL
NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI
GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID
KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG
QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES
GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR
ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE
YGFHEYTEVKTVTVKISQKNS

Target 13 Number of Residues

501

Target 13 Molecular Weight

54861.4

Target 13 Theoretical pI

6.71

Target 13 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 13 General Function

Energy production and conversion

Target 13 Pathways

Cofactor metabolism; retinol metabolism

Target 13 Reactions

Not Available

Target 13 Signals

None

Target 13 Transmembrane Regions

None

Target 13 Essentiality

Non Essential

Target 13 Domain Function

PF00171:Aldedh

Target 13 GenBank ID Protein

Not Available

Target 13 UniProtKB ID

P00352

Target 13 Cellular Location

Cytoplasm

Target 13 Gene Sequence

Not Available

Target 13 GenBank Gene ID

Not Available

Target 13 GeneCard ID

ALDH1A1

Target 13 GenAtlas ID

ALDH1A1

Target 13 HGNC ID

HGNC:402

Target 13 Chromosome Location

Not Available

Target 13 Locus

9q21.13

Target 13 SNPs

SNPJam Report Link Image

Target 13 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 13 General References

2591967; 8214422; 15489334; 8493914; 6723659; 4015823; 2987944

Target 14 [top]

Target 14 ID

332

Target 14 Name

Retinal dehydrogenase 2

Target 14 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 14 Description

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity)

Target 14 Synonyms

RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II)

Target 14 Gene Name

ALDH1A2

Target 14 Protein Sequence

>Retinal dehydrogenase 2

MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP
GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS

Target 14 Number of Residues

518

Target 14 Molecular Weight

56723.5

Target 14 Theoretical pI

5.84

Target 14 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 14 General Function

Energy production and conversion

Target 14 Pathways

Cofactor metabolism; retinol metabolism

Target 14 Reactions

Not Available

Target 14 Signals

None

Target 14 Transmembrane Regions

None

Target 14 Essentiality

Non Essential

Target 14 Domain Function

PF00171:Aldedh

Target 14 GenBank ID Protein

Not Available

Target 14 UniProtKB ID

O94788

Target 14 Cellular Location

Cytoplasm

Target 14 Gene Sequence

>1557 bp

ATGACTTCCAGCAAGATAGAGATGCCCGGCGAGGTGAAGGCCGACCCCGCCGCCCTCATG
GCGTCGCTGCACCTCCTGCCGTCGCCCACGCCCAATCTCGAAATTAAGTACACCAAGATC
TTTATAAACAACGAGTGGCAGAACTCAGAGAGTGGGAGAGTGTTCCCTGTCTATAATCCA
GCCACAGGAGAACAGGTGTGTGAAGTTCAAGAAGCAGACAAGGCAGATATAGACAAAGCA
GTGCAGGCAGCCCGCCTGGCTTTCTCTCTTGGTTCAGTGTGGAGAAGGATGGATGCTTCA
GAAAGGGGACGTCTGTTGGATAAGCTTGCAGACTTGGTGGAACGGGACAGGGCAGTTCTT
GCAACCATGGAATCCCTAAATGGTGGCAAACCATTCCTGCAAGCTTTTTATGTGGATTTG
CAGGGCGTCATCAAAACCTTTCGATATTACGCAGGCTGGGCTGATAAAATTCATGGGATG
ACCATTCCTGTAGATGGAGACTATTTTACCTTTACAAGACATGAACCCATTGGAGTGTGT
GGACAGATCATCCCATGGAACTTCCCCCTGCTGATGTTTGCCTGGAAAATAGCTCCAGCT
TTGTGCTGTGGCAATACAGTAGTTATTAAGCCAGCAGAGCAAACACCACTCAGTGCACTC
TACATGGGAGCCCTCATCAAGGAGGCTGGCTTTCCTCCCGGGGTCATCAATATTTTGCCA
GGATATGGGCCAACGGCTGGGGCAGCAATAGCTTCTCACATTGGCATAGACAAGATTGCA
TTCACAGGGTCTACTGAGGTTGGAAAGCTTATCCAAGAAGCAGCTGGAAGAAGTAATTTG
AAGAGAGTAACTCTGGAACTTGGAGGCAAAAGTCCTAATATTATTTTTGCTGATGCTGAC
TTGGACTATGCTGTGGAGCAGGCCCACCAGGGTGTGTTCTTCAATCAAGGTCAGTGCTGC
ACTGCAGGCTCTCGCATCTTCGTGGAGGAGTCCATCTATGAGGAGTTTGTGAGAAGAAGC
GTGGAGCGGGCCAAGAGGCGCATAGTGGGGAGTCCCTTTGACCCCACCACTGAGCAGGGT
CCCCAGATTGATAAGAAACAGTACAACAAGATCTTGGAACTCATCCAGAGTGGTGTGGCT
GAGGGCGCCAAGCTGGAATGTGGAGGCAAAGGACTGGGCCGAAAGGGGTTTTTCATTGAG
CCCACAGTGTTTTCCAACGTCACTGATGATATGCGGATTGCCAAGGAGGAGATCTTTGGC
CCTGTTCAGGAAATTTTGAGATTTAAGACGATGGATGAAGTTATCGAAAGAGCCAATAAC
TCAGACTTTGGACTCGTAGCAGCTGTCTTTACTAATGACATCAACAAGGCCCTCACAGTG
TCTTCTGCAATGCAAGCTGGGACTGTTTGGATCAATTGTTACAATGCCTTAAATGCCCAG
AGCCCCTTTGGGGGATTCAAGATGTCTGGAAATGGGAGAGAAATGGGAGAATTTGGCTTG
CGGGAGTACTCAGAAGTTAAGACGGTGACAGTAAAGATCCCCCAGAAGAACTCCTAA

Target 14 GenBank Gene ID

Not Available

Target 14 GeneCard ID

ALDH1A2

Target 14 GenAtlas ID

ALDH1A2

Target 14 HGNC ID

HGNC:15472 Link Image

Target 14 Chromosome Location

Chromosome:15

Target 14 Locus

15q22.1

Target 14 SNPs

SNPJam Report Link Image

Target 14 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 14 General References

9819382; 14702039; 15489334; 17974005

Target 15 [top]

Target 15 ID

327

Target 15 Name

Aldehyde dehydrogenase family 3 member B1

Target 15 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 15 Description

An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

Target 15 Synonyms

Aldehyde dehydrogenase 7

Target 15 Gene Name

ALDH3B1

Target 15 Protein Sequence

>Aldehyde dehydrogenase family 3 member B1

MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL

Target 15 Number of Residues

468

Target 15 Molecular Weight

51839.2

Target 15 Theoretical pI

7.67

Target 15 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 15 General Function

Energy production and conversion

Target 15 Pathways

Alcohol metabolism; ethanol degradation; acetate from ethanol:step 2/2

Target 15 Reactions

Not Available

Target 15 Signals

None

Target 15 Transmembrane Regions

None

Target 15 Essentiality

Non Essential

Target 15 Domain Function

PF00171:Aldedh

Target 15 GenBank ID Protein

Not Available

Target 15 UniProtKB ID

P43353

Target 15 Cellular Location

Not Available

Target 15 Gene Sequence

>1407 bp

ATGGACCCCCTTGGGGACACGCTGCGGCGACTGCGGGAGGCCTTCCACGCGGGGCGCACG
CGGCCAGCTGAGTTCCGGGCTGCGCAGCTCCAAGGCCTGGGCCGCTTCCTGCAAGAAAAC
AAGCAGCTTCTGCACGACGCACTGGCCCAGGACCTGCACAAGTCAGCCTTCGAGTCGGAG
GTGTCTGAGGTTGCCATCAGCCAGGGCGAGGTCACCCTGGCCCTCAGGAACCTCCGGGCC
TGGATGAAGGACGAGCGTGTGCCCAAGAACCTGGCCACGCAGCTGGACTCCGCCTTCATC
CGGAAGGAGCCCTTTGGCCTGGTCCTCATCATTGCGCCCTGGAACTATCCGCTGAACCTG
ACGCTGGTGCCCCTCGTGGGAGCCCTCGCTGCAGGGAACTGTGTGGTGCTGAAGCCATCG
GAGATTAGCAAGAACGTCGAGAAGATCCTGGCCGAGGTGCTGCCCCAATACGTGGACCAG
AGCTGCTTTGCTGTGGTGCTGGGCGGGCCCCAGGAGACGGGGCAGCTGCTAGAGCACAGG
TTCGACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTTATGACTGCTGCC
GCCAAGCACCTGACACCTGTCACCCTGGAGCTGGGGGGCAAGAACCCTTGCTACGTGGAC
GACAACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCCGCTACTTCAACGCC
GGCCAGACCTGCGTGGCCCCCGACTACGTCCTATGCAGCCCTGAGATGCAGGAGAGGCTG
CTGCCTGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCA
AACCTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGC
GGCCGTGTGGCCATTGGGGGCCAGAGCGATGAGAGCGATCGCTACATCGCCCCCACGGTG
CTGGTGGATGTGCAGGAGATGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTG
CCCATCGTGAACGTGCAGAGCTTGGACGAGGCCATCGAGTTCATCAACCGGCGGGAGAAG
CCCCTGGCCCTGTACGCCTTCTCCAACAGCAGCCAGGTGGTCAAGCGGGTGCTGACCCAG
ACCAGCAGCGGGGGCTTCTGTGGGAACGACGGCTTCATGCACATGACCCTGGCCAGCCTG
CCTTTTGGAGGAGTGGGTGCCAGTGGGATGGGCCGGTACCATGGCAAGTTCTCCTTCGAC
ACCTTCTCCCACCATCGCGCCTGCCTCCTGCGCAGCCCGGGGATGGAGAAGCTCAACGCC
CTCCGCTACCCGCCGCAATCGCCGCGCCGCCTGAGGATGCTGCTGGTGGCCATGGAGGCC
CAAGGCTGCAGCTGCACACTGCTCTGA

Target 15 GenBank Gene ID

Not Available

Target 15 GeneCard ID

ALDH3B1

Target 15 GenAtlas ID

ALDH3B1

Target 15 HGNC ID

HGNC:410

Target 15 Chromosome Location

Chromosome:11

Target 15 Locus

11q13

Target 15 SNPs

SNPJam Report Link Image

Target 15 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 15 General References

7828891; 15489334; 18187866

Target 16 [top]

Target 16 ID

323

Target 16 Name

Aldehyde dehydrogenase family 3 member B2

Target 16 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 16 Description

An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

Target 16 Synonyms

Aldehyde dehydrogenase 8

Target 16 Gene Name

ALDH3B2

Target 16 Protein Sequence

>Aldehyde dehydrogenase family 3 member B2

MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGNCVVLKPSE
ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT
KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL
PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL
VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT
SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI
RYPPYTDWNQQLLRWGMGSQSCTLL

Target 16 Number of Residues

385

Target 16 Molecular Weight

42669.7

Target 16 Theoretical pI

5.97

Target 16 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 16 General Function

Energy production and conversion

Target 16 Pathways

Alcohol metabolism; ethanol degradation; acetate from ethanol:step 2/2

Target 16 Reactions

Not Available

Target 16 Signals

None

Target 16 Transmembrane Regions

None

Target 16 Essentiality

Non Essential

Target 16 Domain Function

PF00171:Aldedh

Target 16 GenBank ID Protein

Not Available

Target 16 UniProtKB ID

P48448

Target 16 Cellular Location

Not Available

Target 16 Gene Sequence

>1158 bp

ATGAAGGATGAACCACGGTCCACGAACCTGTTCATGAAGCTGGACTCGGTCTTCATCTGG
AAGGAACCCTTTGGCCTGGTCCTCATCATCGCACCCTGGAACTACCCATTGAACCTGACC
CTGGTGCTCCTGGTGGGCACCCTCCCCGCAGGGAATTGCGTGGTGCTGAAGCCGTCAGAA
ATCAGCCAGGGCACAGAGAAGGTCCTGGCTGAGGTGCTGCCCCAGTACCTGGACCAGAGC
TGCTTTGCCGTGGTGCTGGGCGGACCCCAGGAGACAGGGCAGCTGCTAGAGCACAAGTTG
GACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTCATGACTGCTGCCACC
AAGCACCTGACGCCTGTCACCCTGGAGCTGGGGGGCAAGAACCCCTGCTACGTGGACGAC
AACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCTGCTACTTCAATGCCGGC
CAGACCTGCGTGGCCCCTGACTACGTCCTGTGCAGCCCCGAGATGCAGGAGAGGCTGCTG
CCCGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCAAAC
CTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGCGGC
CGCGTGGCCATTGGGGGCCAGAGCAACGAGAGCGATCGCTACATCGCCCCCACGGTGCTG
GTGGACGTGCAGGAGACGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTGCCC
ATCGTGAACGTGCAGAGCGTGGACGAGGCCATCAAGTTCATCAACCGGCAGGAGAAGCCC
CTGGCCCTGTACGCCTTCTCCAACAGCAGACAGGTTGTGAACCAGATGCTGGAGCGGACC
AGCAGCGGCAGCTTTGGAGGCAATGAGGGCTTCACCTACATATCTCTGCTGTCCGTGCCA
TTCGGGGGAGTCGGCCACAGTGGGATGGGCCGGTACCACGGCAAGTTCACCTTCGACACC
TTCTCCCACCACCGCACCTGCCTGCTCGCCCCCTCCGGCCTGGAGAAATTAAAGGAGATC
CGCTACCCACCCTATACCGACTGGAACCAGCAGCTGTTACGCTGGGGCATGGGCTCCCAG
AGCTGCACCCTCCTGTGA

Target 16 GenBank Gene ID

Not Available

Target 16 GeneCard ID

ALDH3B2

Target 16 GenAtlas ID

ALDH3B2

Target 16 HGNC ID

HGNC:411

Target 16 Chromosome Location

Chromosome:11

Target 16 Locus

11q13

Target 16 SNPs

SNPJam Report Link Image

Target 16 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 16 General References

7484374; 8890755; 14702039; 16554811; 15489334

Target 17 [top]

Target 17 ID

324

Target 17 Name

Aldehyde dehydrogenase X, mitochondrial

Target 17 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 17 Description

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

Target 17 Synonyms

Aldehyde dehydrogenase family 1 member B1; Aldehyde dehydrogenase 5

Target 17 Gene Name

ALDH1B1

Target 17 Protein Sequence

>Aldehyde dehydrogenase X, mitochondrial

MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

Target 17 Number of Residues

517

Target 17 Molecular Weight

57238.0

Target 17 Theoretical pI

6.79

Target 17 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 17 General Function

Energy production and conversion

Target 17 Pathways

Alcohol metabolism; ethanol degradation; acetate from ethanol:step 2/2

Target 17 Reactions

Not Available

Target 17 Signals

None

Target 17 Transmembrane Regions

None

Target 17 Essentiality

Non Essential

Target 17 Domain Function

PF00171:Aldedh

Target 17 GenBank ID Protein

Not Available

Target 17 UniProtKB ID

P30837

Target 17 Cellular Location

Mitochondrion matrix

Target 17 Gene Sequence

Not Available

Target 17 GenBank Gene ID

Not Available

Target 17 GeneCard ID

ALDH1B1

Target 17 GenAtlas ID

ALDH1B1

Target 17 HGNC ID

HGNC:407

Target 17 Chromosome Location

Not Available

Target 17 Locus

9p11.1

Target 17 SNPs

SNPJam Report Link Image

Target 17 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 17 General References

2061311; 14702039; 15164053; 15489334; 8244338

Target 18 [top]

Target 18 ID

334

Target 18 Name

10-formyltetrahydrofolate dehydrogenase

Target 18 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 18 Description

10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH

Target 18 Synonyms

10-FTHFDH; Aldehyde dehydrogenase family 1 member L1

Target 18 Gene Name

ALDH1L1

Target 18 Protein Sequence

>10-formyltetrahydrofolate dehydrogenase

MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWR
AKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAIN
WTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAV
RLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQ
KLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMI
LASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRL
VEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRM
PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI
SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI
QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ
VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK
SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH
DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP
RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT
RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF
EY

Target 18 Number of Residues

902

Target 18 Molecular Weight

98828.5

Target 18 Theoretical pI

5.76

Target 18 GO Classification

Function
binding vitamin binding phosphopantetheine binding transferase activity transferase activity, transferring one-carbon groups methyltransferase activity glycine hydroxymethyltransferase activity hydroxymethyl-, formyl- and related transferase activity catalytic activity oxidoreductase activity oxidoreductase activity, acting on the CH-NH group of donors oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor formyltetrahydrofolate dehydrogenase activity
Process
biosynthesis aromatic compound metabolism folic acid and derivative metabolism 10-formyltetrahydrofolate metabolism 10-formyltetrahydrofolate catabolism physiological process metabolism cellular metabolism one-carbon compound metabolism
Component
cell intracellular cytoplasm

Target 18 General Function

Energy production and conversion

Target 18 Pathways

Not Available

Target 18 Reactions

Not Available

Target 18 Signals

None

Target 18 Transmembrane Regions

None

Target 18 Essentiality

Non Essential

Target 18 Domain Function

PF00171:Aldedh PF02911:Formyl_trans_C PF00551:Formyl_trans_N

Target 18 GenBank ID Protein

Not Available

Target 18 UniProtKB ID

O75891

Target 18 Cellular Location

Cytoplasm

Target 18 Gene Sequence

>2709 bp

ATGAAGATTGCAGTGATTGGACAGAGCCTGTTTGGCCAGGAAGTTTACTGCCACCTGAGG
AAGGAGGGCCACGAAGTGGTGGGTGTGTTCACTGTTCCAGACAAGGATGGAAAGGCCGAC
CCCCTGGGTCTGGAAGCTGAGAAGGATGGAGTGCCGGTATTCAAGTACTCCCGGTGGCGT
GCAAAAGCGCAAGCTTTGCCTGATGTGGTGGCAAAATACCAGGCTTTGGGGGCCGAACTC
AACGTCCTGCCCTCCTGCAGCCAATTCATCCCCATGGAGATAATCAGTGCCCCCCGGCAT
GGCTCCATCATCTATCACCCGTCACTGCTCCCTAGGCACCGAGGGGCCTCGGCCATCAAC
TGGACCCTCATTCACGGAGATAAGAAAGGGGGGTTTTCCATCTTCTGGGCGGATGATGGT
CTGGACACCGGAGACCTGCTGCTGCAGAAGGAGTGTGAGGTGCTCCCGGACGACACCGTG
AGCACGCTGTACAACCGCTTCCTCTTCCCTGAAGGCATCAAAGGGGTGGTGCAGGCCGTG
AGGCTGATCGCTGAGGGCAAAGCCCCCAGACTCCCTCAGCCTAAGGAAGGAGCCACCTAT
GAGGGGATTCAGAAGAAGGAGACAGCCAAGATCAACTGGGACCAGCCGGCAGAGGCCATT
CACAACTGGATCCGCGGGAACGACAAGGTGCCGGGAGCCTGGACAGAGGCCTGTGAACAG
AAACTGACATTTTTCAACTCAACGCTGAACACTTCAGGCCTGGTGCCCGAGGGAGACGCT
TTGCCCATCCCAGGAGCCCATCGGCCAGGGGTGGTCACCAAAGCAGGACTCATCCTCTTT
GGGAATGATGACAAAATGCTGCTGGTGAAGAATATTCAGCTGGAGGATGGCAAAATGATC
CTGGCCTCGAACTTCTTTAAGGGGGCAGCCAGCAGTGTCCTTGAGCTGACAGAGGCAGAG
CTGGTTACTGCGGAGGCTGTGCGGAGTGTTTGGCAGCGGATCCTCCCCAAAGTACTGGAG
GTTGAAGACTCCACTGATTTCTTCAAGTCAGGGGCCGCGTCTGTGGACGTTGTGAGGCTG
GTGGAGGAAGTGAAGGAGCTGTGTGATGGCCTGGAGTTAGAAAATGAAGATGTGTACATG
GCATCCACCTTTGGGGACTTCATCCAGCTGTTAGTGAGGAAGCTGCGAGGGGACGATGAG
GAGGGCGAGTGCAGCATTGACTACGTGGAAATGGCAGTGAACAAGCGCACTGTCCGCATG
CCCCACCAGCTCTTCATTGGGGGGGAGTTCGTGGATGCCGAGGGCGCCAAGACCTCTGAG
ACCATCAATCCCACCGATGGAAGTGTCATCTGCCAGGTATCCCTGGCCCAAGTCACCGAC
GTCGACAAGGCAGTGGCCGCNGCCAAGGGTGCCTTTGAGAATGGACGGTGGGGGAAGATC
AGTGCGCGGGACCGGGGCCGGCTGATGTACAGGTTGGCAGATCTCATGGAGCAGCACCAG
GAGGAGCTGGCCACCATTGAGGCCCTGGATGCGGGTGCCGTCTACACGCTGGCCCTGAAG
ACCCACGTGGGCATGTCCATCCAGACCTTCCGATACTTTGCTGGCTGGTGTGACAAGATC
CAGGGCTCCACCATCCCCATCAACCAGGCCAGACCCAACCGCAACCTGACCTTGACCAGG
AAGGAGCCTGTTGGGGTTTGTGGCATCATCATCCCCTGGAACTATCCCCTGATGATGCTG
TCCTGGAAGACAGCTGCCTGCCTGGCTGCCGGGAACACAGTGGTGATCAAGCCTGCTCAG
GTGACCCCACTCACAGCCTTGAAGTTTGCAGAGCTGACATTAAAGGCCGGGATTCCCAAA
GGTGTGGTCAACGTCCTCCCAGGATCTGGCTCCCTGGTCGGCCAGAGACTCTCAGACCAT
CCTGATGTGAGGAAAATCGGGTTCACAGGCTCCACAGAGGTGGGCAAGCACATCATGAAA
AGCTGTGCCATAAGTAACGTGAAGAAGGTGTCCCTGGAACTGGGCGGGGAGTCACCCTTC
ATCATCTTTGCTGACTGTGACCTCAACAAGGCTGTGCAGATGGGGATGAGTTCTGTTTTC
TTCAGCAAAGGAGAGAATTGCATTGCAGCAGGCCGACTCTTTGTGGAGGACTCCATTCAT
GATGAGTTCGTGCGGAGAGTGGTAGAAGAGGTGCGGAAGATGAAGGTGGGCAACCCGCTG
GACAGGGACACCGACCACGGGCCGCAGAATCACCATGCCCACCTTGTGAAGCTGATGGAG
TACTGCCAGCATGGCGTGAAGGAAGGGGCCACACTGGTCTGCGGCGGGAATCAGGTCCCT
CGGCCAGGGTTCTTCTTTGAGCCAACTGTTTTCACAGACGTGGAAGACCACATGTTCATA
GCCAAGGAGGAGTCCTTCGGGCCTGTCATGATCATCTCTCGGTTTGCTGATGGGGACTTG
GATGCCGTGCTGTCTCGGGCCAATGCCACGGAATTTGGCCTGGCTTCTGGTGTCTTCACC
AGGGACATCAACAAGGCCCTGTATGTCAGTGACAAGCTCCAGGCAGGCACTGTGTTTGTC
AACACGTACAACAAGACCGACGTGGCCGCTCCCTTCGGAGGATTCAAACAGTCTGGATTT
GGCAAAGATCTAGGAGAGGCGGCTCTGAACGAGTACCTGCGGGTCAAGACAGTGACCTTC
GAATACTGA

Target 18 GenBank Gene ID

Not Available

Target 18 GeneCard ID

ALDH1L1

Target 18 GenAtlas ID

ALDH1L1

Target 18 HGNC ID

HGNC:3978

Target 18 Chromosome Location

Not Available

Target 18 Locus

3q21.2

Target 18 SNPs

SNPJam Report Link Image

Target 18 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 18 General References

17974005; 16959974

Target 19 [top]

Target 19 ID

331

Target 19 Name

Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2

Target 19 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 19 Description

10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH

Target 19 Synonyms

Aldehyde dehydrogenase family 1 member L2

Target 19 Gene Name

ALDH1L2

Target 19 Protein Sequence

>Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2

MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGK
ADPLALAAEKDGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSP
KHGSIIYHPSILPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPND
TVDALYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAE
VLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGEPLEIKGAKKPGLVTKNGLVL
FGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVP
IIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGED
QEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLA
DVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLAL
KTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMM
LAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSE
HPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAV
FFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLL
QYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGD
IDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSG
FGKDLGEEALNEYLKTKTVTLEY

Target 19 Number of Residues

923

Target 19 Molecular Weight

101745.0

Target 19 Theoretical pI

6.47

Target 19 GO Classification

Function
binding vitamin binding phosphopantetheine binding transferase activity transferase activity, transferring one-carbon groups methyltransferase activity glycine hydroxymethyltransferase activity hydroxymethyl-, formyl- and related transferase activity catalytic activity oxidoreductase activity oxidoreductase activity, acting on the CH-NH group of donors oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor formyltetrahydrofolate dehydrogenase activity
Process
biosynthesis aromatic compound metabolism folic acid and derivative metabolism 10-formyltetrahydrofolate metabolism 10-formyltetrahydrofolate catabolism physiological process metabolism cellular metabolism one-carbon compound metabolism
Component
cell intracellular cytoplasm

Target 19 General Function

Energy production and conversion

Target 19 Pathways

Not Available

Target 19 Reactions

Not Available

Target 19 Signals

None

Target 19 Transmembrane Regions

None

Target 19 Essentiality

Non Essential

Target 19 Domain Function

PF00171:Aldedh PF02911:Formyl_trans_C PF00551:Formyl_trans_N

Target 19 GenBank ID Protein

Not Available

Target 19 UniProtKB ID

Q3SY69

Target 19 Cellular Location

Not Available

Target 19 Gene Sequence

>2772 bp

ATGCTGCGGCGGGGCAGCCAGGCGCTCCGGCGCTTCTCCACTGGCCGGGTTTATTTCAAA
AACAAGCTGAAGTTGGCACTAATTGGCCAGAGCCTCTTTGGACAAGAAGTCTATAGCCAC
CTCCGCAAAGAGGGCCACCGAGTAGTAGGGGTGTTCACAGTTCCAGACAAGGATGGAAAA
GCTGACCCTCTGGCTTTGGCTGCAGAGAAAGATGGGACCCCTGTGTTCAAGCTTCCTAAA
TGGAGGGTCAAGGGCAAGACCATCAAAGAAGTGGCAGAAGCCTACAGATCCGTGGGTGCA
GAGCTAAATGTGCTCCCTTTCTGCACTCAGTTCATTCCCATGGATATAATTGATAGTCCA
AAGCACGGCTCTATCATTTATCACCCATCCATCCTGCCCAGGCACAGAGGAGCCTCTGCT
ATCAATTGGACTCTAATTATGGGAGATAAGAAAGCTGGGTTTTCTGTTTTCTGGGCTGAT
GATGGCTTGGATACAGGACCCATCCTTCTTCAGAGATCATGTGATGTTGAACCCAATGAT
ACAGTGGATGCACTTTATAATCGGTTTCTTTTTCCTGAAGGAATCAAGGCCATGGTAGAA
GCTGTCCAACTCATAGCTGATGGAAAAGCTCCTCGTATACCCCAGCCAGAAGAAGGGGCA
ACATATGAAGGTATCCAGAAAAAGGAAAATGCTGAGATTTCTTGGGACCAGTCTGCCGAA
GTTTTACATAACTGGATTCGAGGTCATGATAAAGTCCCTGGAGCTTGGACAGAGATAAAT
GGACAGATGGTCACTTTCTATGGCTCGACATTACTGAATAGCTCTGTGCCTCCTGGAGAA
CCACTGGAAATTAAAGGTGCCAAGAAGCCTGGTCTCGTTACCAAAAATGGACTTGTTCTT
TTTGGTAACGATGGAAAAGCACTGACGGTGAGAAATCTGCAGTTTGAAGATGGAAAAATG
ATCCCTGCCTCTCAGTACTTTTCAACGGGTGAGACGTCAGTGGTAGAACTGACAGCTGAA
GAGGTGAAAGTGGCAGAGACCATCAAGGTCATCTGGGCTGGAATTTTAAGCAATGTCCCC
ATTATTGAAGACTCAACAGACTTCTTTAAATCTGGAGCAAGCTCAATGGATGTTGCCAGG
CTGGTTGAAGAGATCAGACAGAAATGTGGTGGGCTTCAGTTGCAGAATGAAGATGTCTAT
ATGGCCACCAAGTTTGAAGGCTTTATCCAAAAGGTCGTGAGGAAACTGAGAGGAGAAGAT
CAAGAGGTGGAGCTGGTTGTAGATTATATTTCAAAGGAGGTCAATGAAATCATGGTAAAA
ATGCCATACCAGTGTTTCATAAATGGACAGTTCACAGATGCAGACGATGGAAAGACTTAC
GACACTATCAACCCAACAGATGGATCTACAATATGCAAAGTATCCTACGCTTCTTTGGCG
GATGTTGATAAAGCAGTAGCAGCAGCAAAAGATGCTTTTGAAAACGGTGAATGGGGAAGA
ATGAATGCAAGAGAAAGAGGAAGATTGATGTATAGACTTGCAGACCTACTGGAAGAGAAC
CAAGAAGAGCTGGCAACTATTGAAGCCCTTGATTCAGGGGCTGTCTATACCTTGGCCCTG
AAGACACACATTGGAATGTCTGTGCAAACATTCAGATATTTTGCTGGCTGGTGCGACAAA
ATTCAGGGTTCTACTATTCCAATCAACCAGGCCCGTCCAAATCGCAATCTGACCTTCACC
AAGAAAGAGCCACTCGGTGTCTGTGCCATTATTATTCCCTGGAACTACCCGCTGATGATG
CTGGCATGGAAGAGTGCTGCGTGTTTGGCAGCAGGCAATACCTTAGTGCTCAAGCCAGCA
CAGGTCACACCCTTGACTGCTTTGAAGTTTGCAGAACTGTCTGTGAAAGCAGGCTTTCCA
AAGGGGGTCATCAACATCATTCCAGGCTCAGGTGGCATAGCAGGACAACGTCTGTCTGAA
CATCCTGACATCCGCAAACTTGGTTTCACTGGTTCCACTCCTATTGGCAAACAGATCATG
AAGAGCTGTGCTGTTAGCAACTTGAAGAAAGTTTCCCTTGAGCTTGGTGGCAAGTCTCCA
CTTATAATATTTAATGACTGTGAACTTGACAAGACTGTGCGAATGGGCATGGGAGCAGTA
TTTTTCAACAAAGGAGAGAACTGTATTGCTGCTGGGCGGTTGTTCGTGGAAGAATCCATC
CACGACGAATTTGTGACAAGAGTGGTAGAAGAAATTAAAAAGATGAAAATTGGTGATCCA
CTTGACAGATCCACTGATCATGGGCCCCAAAATCATAAGGCTCATCTGGAAAAGCTGCTG
CAATACTGTGAAACTGGAGTGAAAGAAGGGGCCACTTTGGTGTACGGGGGAAGACAAGTC
CAAAGGCCAGGCTTTTTCATGGAGCCGACCGTGTTCACAGATGTGGAAGACTACATGTAC
CTCGCCAAAGAGGAATCCTTTGGGCCTATTATGGTCATTTCTAAATTCCAAAATGGGGAC
ATCGATGGAGTGTTGCAGCGAGCAAATAGTACAGAGTATGGTTTGGCCTCAGGGGTTTTT
ACAAGAGACATAAACAAAGCTATGTATGTGAGTGAAAAACTGGAAGCAGGAACTGTTTTT
ATTAACACATACAACAAGACAGATGTGGCGGCCCCATTTGGCGGAGTTAAACAATCTGGC
TTTGGAAAAGACTTAGGTGAGGAAGCTCTAAATGAATATCTCAAAACCAAGACGGTGACA
CTGGAATATTAG

Target 19 GenBank Gene ID

Not Available

Target 19 GeneCard ID

ALDH1L2

Target 19 GenAtlas ID

ALDH1L2

Target 19 HGNC ID

HGNC:26777 Link Image

Target 19 Chromosome Location

Chromosome:12

Target 19 Locus

12q23.3

Target 19 SNPs

SNPJam Report Link Image

Target 19 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 19 General References

15489334; 14702039; 17974005

Target 20 [top]

Target 20 ID

338

Target 20 Name

Transient receptor potential cation channel subfamily A member 1

Target 20 Mechanism of Action

Acrolein activates the transient receptor potential cation channel, causing acute pain. (R229)

Target 20 Description

Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity)

Target 20 Synonyms

Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120

Target 20 Gene Name

TRPA1

Target 20 Protein Sequence

>Transient receptor potential cation channel subfamily A member 1

MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
LQILLNKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP

Target 20 Number of Residues

1119

Target 20 Molecular Weight

127485.8

Target 20 Theoretical pI

7.08

Target 20 GO Classification

Function
transporter activity ion transporter activity ion channel activity
Process
physiological process cellular physiological process transport ion transport
Component
cell membrane

Target 20 General Function

Not Available

Target 20 Pathways

Not Available

Target 20 Reactions

Not Available

Target 20 Signals

None

Target 20 Transmembrane Regions

720-740
773-793
806-826
830-850
874-894
941-961

Target 20 Essentiality

Non Essential

Target 20 Domain Function

PF00023:Ank PF00520:Ion_trans

Target 20 GenBank ID Protein

Not Available

Target 20 UniProtKB ID

O75762

Target 20 Cellular Location

Membrane

Target 20 Gene Sequence

>3360 bp

ATGAAGTGCAGCCTGAGGAAGATGTGGCGCCCTGGAGAAAAGAAGGAGCCCCAGGGCGTT
GTCTATGAGGATGTGCCGGACGACACGGAGGATTTCAAGGAATCGCTTAAGGTGGTTTTT
GAAGGAAGTGCATATGGATTACAAAACTTTAATAAGCAAAAGAAATTAAAAACATGTGAC
GATATGGACACCTTCTTCTTGCATTATGCTGCAGCAGAAGGCCAAATTGAGCTAATGGAG
AAGATCACCAGAGATTCCTCTTTGGAAGTGCTGCATGAAATGGATGATTATGGAAATACC
CCTCTGCATTGTGCTGTAGAAAAAAACCAAATTGAAAGCGTTAAGTTTCTTCTCAGCAGA
GGAGCAAACCCAAACCTCCGAAACTTCAACATGATGGCTCCTCTCCACATAGCTGTGCAG
GGCATGAATAATGAGGTGATGAAGGTCTTGCTTGAGCATAGAACTATTGATGTTAATTTG
GAAGGAGAAAATGGAAACACAGCTGTGATCATTGCGTGCACCACAAATAATAGCGAAGCA
TTGCAGATTTTGCTTAACAAAGGAGCTAAGCCATGTAAATCAAATAAATGGGGATGTTTC
CCTATTCACCAAGCTGCATTTTCAGGTTCCAAAGAATGCATGGAAATAATACTAAGGTTT
GGTGAAGAGCATGGGTACAGTAGACAGTTGCACATTAACTTTATGAATAATGGGAAAGCC
ACCCCTCTCCACCTGGCTGTGCAAAATGGTGACTTGGAAATGATCAAAATGTGCCTGGAC
AATGGTGCACAAATAGACCCAGTGGAGAAGGGAAGGTGCACAGCCATTCATTTTGCTGCC
ACCCAGGGAGCCACTGAGATTGTTAAACTGATGATATCGTCCTATTCTGGTAGCGTGGAT
ATTGTTAACACAACCGATGGATGTCATGAGACCATGCTTCACAGAGCTTCATTGTTTGAT
CACCATGAGCTAGCAGACTATTTAATTTCAGTGGGAGCAGATATTAATAAGATCGATTCT
GAAGGACGCTCTCCACTTATATTAGCAACTGCTTCTGCATCTTGGAATATTGTAAATTTG
CTACTCTCTAAAGGTGCCCAAGTAGACATAAAAGATAATTTTGGACGTAATTTTCTGCAT
TTAACTGTACAGCAACCTTATGGATTAAAAAATCTGCGACCTGAATTTATGCAGATGCAA
CAGATCAAAGAGCTGGTAATGGATGAAGACAACGATGGGTGTACTCCTCTACATTATGCA
TGTAGACAGGGGGGCCCTGGTTCTGTAAATAACCTACTTGGCTTTAATGTGTCCATTCAT
TCCAAAAGCAAAGATAAGAAATCACCTCTGCATTTTGCAGCCAGTTATGGGCGTATCAAT
ACCTGTCAGAGGCTCCTACAAGACATAAGTGATACGAGGCTTCTGAATGAAGGTGACCTT
CATGGAATGACTCCTCTCCATCTGGCAGCAAAGAATGGACATGATAAAGTAGTTCAGCTT
CTTCTGAAAAAAGGTGCATTGTTTCTCAGTGACCACAATGGCTGGACAGCTTTGCATCAT
GCGTCCATGGGCGGGTACACTCAGACCATGAAGGTCATTCTTGATACTAATTTGAAGTGC
ACAGATCGCTTGGATGAAGACGGGAACACTGCACTTCACTTTGCTGCAAGGGAAGGCCAC
GCCAAAGCCGTTGCGCTTCTTCTGAGCCACAATGCTGACATAGTCCTGAACAAGCAGCAG
GCCTCCTTTTTGCACCTTGCACTTCACAATAAGAGGAAGGAGGTTGTTCTTACGATCATC
AGGAGCAAAAGATGGGATGAATGTCTTAAGATTTTCAGTCATAATTCTCCAGGCAATAAA
TGTCCAATTACAGAAATGATAGAATACCTCCCTGAATGCATGAAGGTACTTTTAGATTTC
TGCATGTTGCATTCCACAGAAGACAAGTCCTGCCGAGACTATTATATCGAGTATAATTTC
AAATATCTTCAATGTCCATTAGAATTCACCAAAAAAACACCTACACAGGATGTTATATAT
GAACCGCTTACAGCCCTCAACGCAATGGTACAAAATAACCGCATAGAGCTTCTCAATCAT
CCTGTGTGTAAAGAATATTTACTCATGAAATGGTTGGCTTATGGATTTAGAGCTCATATG
ATGAATTTAGGATCTTACTGTCTTGGTCTCATACCTATGACCATTCTCGTTGTCAATATA
AAACCAGGAATGGCTTTCAACTCAACTGGCATCATCAATGAAACTAGTGATCATTCAGAA
ATACTAGATACCACGAATTCATATCTAATAAAAACTTGTATGATTTTAGTGTTTTTATCA
AGTATATTTGGGTATTGCAAAGAAGCGGGGCAAATTTTCCAACAGAAAAGGAATTATTTT
ATGGATATAAGCAATGTTCTTGAATGGATTATCTACACGACGGGCATCATTTTTGTGCTG
CCCTTGTTTGTTGAAATACCAGCTCATCTGCAGTGGCAATGTGGAGCAATTGCTGTTTAC
TTCTATTGGATGAATTTCTTATTGTATCTTCAAAGATTTGAAAATTGTGGAATTTTTATT
GTTATGTTGGAGGTAATTTTGAAAACTTTGTTGAGGTCTACAGTTGTATTTATCTTCCTT
CTTCTGGCTTTTGGACTCAGCTTTTACATCCTCCTGAATTTACAGGATCCCTTCAGCTCT
CCATTGCTTTCTATAATCCAGACCTTCAGCATGATGCTAGGAGATATCAATTATCGAGAG
TCCTTCCTAGAACCATATCTGAGAAATGAATTGGCACATCCAGTTCTGTCCTTTGCACAA
CTTGTTTCCTTCACAATATTTGTCCCAATTGTCCTCATGAATTTACTTATTGGTTTGGCA
GTTGGCGACATTGCTGAGGTCCAGAAACATGCATCATTGAAGAGGATAGCTATGCAGGTG
GAACTTCATACCAGCTTAGAGAAGAAGCTGCCACTTTGGTTTCTACGCAAAGTGGATCAG
AAATCCACCATCGTGTATCCCAACAAACCCAGATCTGGTGGGATGTTATTCCATATATTC
TGTTTTTTATTTTGCACTGGGGAAATAAGACAAGAAATACCAAATGCTGATAAATCTTTA
GAAATGGAAATATTAAAGCAGAAATACCGGCTGAAGGATCTTACTTTTCTCCTGGAAAAA
CAGCATGAGCTCATTAAACTGATCATTCAGAAGATGGAGATCATCTCTGAGACAGAGGAT
GATGATAGCCATTGTTCTTTTCAAGACAGGTTTAAGAAAGAGCAGATGGAACAAAGGAAT
AGCAGATGGAATACTGTGTTGAGAGCAGTCAAGGCAAAAACACACCATCTTGAGCCTTAG

Target 20 GenBank Gene ID

Not Available

Target 20 GeneCard ID

TRPA1

Target 20 GenAtlas ID

TRPA1

Target 20 HGNC ID

HGNC:497

Target 20 Chromosome Location

Not Available

Target 20 Locus

8q13

Target 20 SNPs

SNPJam Report Link Image

Target 20 Toxin References

R229 - Takahashi N, Mizuno Y, Kozai D, Yamamoto S, Kiyonaka S, Shibata T, Uchida K, Mori Y: Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Channels (Austin). 2008 Jul-Aug;2(4):287-98. Epub 2008 Jul 6. [PubMed ]

Target 20 General References

10066796; 16421571

Target 21 [top]

Target 21 ID

330

Target 21 Name

Succinate-semialdehyde dehydrogenase, mitochondrial

Target 21 Mechanism of Action

Acrolein inhibits aldehyde dehydrogenases. (R227)

Target 21 Description

Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH

Target 21 Synonyms

NAD(+)-dependent succinic semialdehyde dehydrogenase; Aldehyde dehydrogenase family 5 member A1

Target 21 Gene Name

ALDH5A1

Target 21 Protein Sequence

>Succinate-semialdehyde dehydrogenase, mitochondrial

MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV
KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF
AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF
EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR
VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL

Target 21 Number of Residues

535

Target 21 Molecular Weight

57214.2

Target 21 Theoretical pI

8.37

Target 21 GO Classification

Function
catalytic activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor aldehyde dehydrogenase activity
Process
Not Available
Component
Not Available

Target 21 General Function

Energy production and conversion

Target 21 Pathways

Amino-acid degradation; 4-aminobutanoate degradation

Target 21 Reactions

Not Available

Target 21 Signals

None

Target 21 Transmembrane Regions

None

Target 21 Essentiality

Non Essential

Target 21 Domain Function

PF00171:Aldedh

Target 21 GenBank ID Protein

Not Available

Target 21 UniProtKB ID

P51649

Target 21 Cellular Location

Mitochondrion

Target 21 Gene Sequence

>1608 bp

ATGGCGACCTGCATTTGGCTGCGGAGCTGTGGGGCCCGGCGCCTCGGGTCGACGTTTCCA
GGCTGCCGCCTCCGCCCCCGCGCCGGCGGCCTGGTCCCTGCCTCCGGGCCTGCGCCCGGC
CCGGCCCAGCTCCGCTGCTACGCTGGGCGCCTGGCGGGCCTCTCTGCGGCGCTGCTGCGC
ACCGACAGCTTCGTGGGCGGCCGCTGGCTCCCGGCCGCCGCCACCTTCCCCGTGCAAGAC
CCGGCCAGCGGCGCCGCTCTGGGCATGGTAGCCGACTGCGGGGTGCGAGAGGCCCGCGCC
GCCGTGCGCGCTGCCTACGAGGCTTTCTGCCGCTGGAGGGAGGTCTCCGCCAAGGAGAGG
AGTTCATTACTTCGGAAGTGGTACAATTTAATGATACAAAATAAGGATGACCTTGCCAGA
ATAATCACAGCTGAAAGTGGAAAGCCACTGAAGGAGGCACATGGAGAAATTCTCTATTCC
GCCTTTTTCCTAGAGTGGTTCTCTGAGGAAGCCCGCCGTGTTTACGGAGACATTATCCAC
ACCCCGGCAAAGGACAGGCGGGCCCTGGTCCTCAAGCAGCCCATAGGCGTGGCTGCAGTC
ATCACCCCGTGGAATTTCCCCAGTGCCATGATCACCCGGAAGGTGGGGGCCGCCCTGGCA
GCCGGCTGTACTGTCGTGGTGAAGCCTGCCGAAGACACGCCCTTCTCCGCCCTGGCCCTG
GCTGAGCTTGCAAGCCAGGCTGGGATTCCTTCAGGTGTATACAATGTTATTCCCTGTTCT
CGAAAGAATGCCAAGGAAGTAGGGGAGGCAATTTGTACTGATCCTCTGGTGTCCAAAATT
TCCTTTACTGGTTCAACAACTACAGGAAAGATCCTGTTGCACCACGCAGCAAACTCTGTG
AAAAGGGTCTCTATGGAGCTGGGCGGCCTTGCTCCATTTATAGTATTTGACAGTGCCAAC
GTGGACCAGGCTGTAGCAGGGGCCATGGCATCTAAATTTAGGAACACTGGACAGACTTGT
GTTTGCTCAAACCAATTCTTGGTGCAAAGGGGCATCCATGATGCCTTTGTAAAAGCATTC
GCCGAGGCCATGAAGAAGAACCTGCGCGTAGGTAATGGATTTGAGGAAGGAACTACTCAG
GGCCCATTAATTAATGAAAAAGCGGTAGAAAAGGTGGAGAAACAGGTGAATGATGCCGTT
TCTAAAGGTGCCACCGTTGTGACAGGTGGAAAACGACACCAACTTGGAAAAAATTTCTTT
GAGCCTACCCTGCTGTGCAATGTCACCCAGGACATGCTGTGCACTCATGAAGAGACTTTC
GGGCCTCTGGCACCAGTTATCAAGTTCGATACAGAGGAGGAGGCTATAGCAATCGCTAAC
GCAGCTGATGTTGGGTTAGCAGGTTATTTTTACTCTCAAGACCCAGCCCAGATCTGGAGA
GTGGCAGAGCAGCTGGAAGTGGGCATGGTTGGCGTCAACGAAGGATTAATTTCCTCTGTG
GAGTGCCCTTTTGGTGGAGTGAAGCAGTCCGGCCTTGGGCGAGAGGGGTCCAAGTATGGC
ATTGATGAGTATCTGGAACTCAAGTATGTGTGTTACGGGGGCTTGTAG

Target 21 GenBank Gene ID

Not Available

Target 21 GeneCard ID

ALDH5A1

Target 21 GenAtlas ID

ALDH5A1

Target 21 HGNC ID

HGNC:408

Target 21 Chromosome Location

Not Available

Target 21 Locus

6p22.2-p22.3

Target 21 SNPs

SNPJam Report Link Image

Target 21 Toxin References

R227 - Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. [PubMed ]

Target 21 General References

9683595; 14702039; 14574404; 15489334; 7814412; 9059628; 11243727; 11901270; 14635103

Target 22 [top]

Target 22 ID

313

Target 22 Name

NF-kappa-B essential modulator

Target 22 Mechanism of Action

Target 22 Description

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa- B-mediated protection from cytokine toxicity (By similarity)

Target 22 Synonyms

NEMO; NF-kappa-B essential modifier; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IkB kinase subunit gamma; I-kappa-B kinase gamma; IKK-gamma; IKKG; IkB kinase-associated protein 1; IKKAP1; FIP-3

Target 22 Gene Name

IKBKG

Target 22 Protein Sequence

>NF-kappa-B essential modulator

MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ
ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE
YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV
LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH
VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE

Target 22 Number of Residues

419

Target 22 Molecular Weight

48197.3

Target 22 Theoretical pI

5.46

Target 22 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 22 General Function

Replication, recombination and repair

Target 22 Pathways

Not Available

Target 22 Reactions

Not Available

Target 22 Signals

None

Target 22 Transmembrane Regions

None

Target 22 Essentiality

Non Essential

Target 22 Domain Function

Not Available

Target 22 GenBank ID Protein

Not Available

Target 22 UniProtKB ID

Q9Y6K9

Target 22 Cellular Location

Cytoplasm. Nucleus

Target 22 Gene Sequence

>1260 bp

ATGAATAGGCACCTCTGGAAGAGCCAACTGTGTGAGATGGTGCAGCCCAGTGGTGGCCCG
GCAGCAGATCAGGACGTACTGGGCGAAGAGTCTCCTCTGGGGAAGCCAGCCATGCTGCAC
CTGCCTTCAGAACAGGGCGCTCCTGAGACCCTCCAGCGCTGCCTGGAGGAGAATCAAGAG
CTCCGAGATGCCATCCGGCAGAGCAACCAGATTCTGCGGGAGCGCTGCGAGGAGCTTCTG
CATTTCCAAGCCAGCCAGAGGGAGGAGAAGGAGTTCCTCATGTGCAAGTTCCAGGAGGCC
AGGAAACTGGTGGAGAGACTCGGCCTGGAGAAGCTCGATCTGAAGAGGCAGAAGGAGCAG
GCTCTGCGGGAGGTGGAGCACCTGAAGAGATGCCAGCAGCAGATGGCTGAGGACAAGGCC
TCTGTGAAAGCCCAGGTGACGTCCTTGCTCGGGGAGCTGCAGGAGAGCCAGAGTCGCTTG
GAGGCTGCCACTAAGGAATGCCAGGCTCTGGAGGGTCGGGCCCGGGCGGCCAGCGAGCAG
GCGCGGCAGCTGGAGAGTGAGCGCGAGGCGCTGCAGCAGCAGCACAGCGTGCAGGTGGAC
CAGCTGCGCATGCAGGGCCAGAGCGTGGAGGCCGCGCTCCGCATGGAGCGCCAGGCCGCC
TCGGAGGAGAAGAGGAAGCTGGCCCAGTTGCAGGTGGCCTATCACCAGCTCTTCCAAGAA
TACGACAACCACATCAAGAGCAGCGTGGTGGGCAGTGAGCGGAAGCGAGGAATGCAGCTG
GAAGATCTCAAACAGCAGCTCCAGCAGGCCGAGGAGGCCCTGGTGGCCAAACAGGAGGTG
ATCGATAAGCTGAAGGAGGAGGCCGAGCAGCACAAGATTGTGATGGAGACCGTTCCGGTG
CTGAAGGCCCAGGCGGATATCTACAAGGCGGACTTCCAGGCTGAGAGGCAGGCCCGGGAG
AAGCTGGCCGAGAAGAAGGAGCTCCTGCAGGAGCAGCTGGAGCAGCTGCAGAGGGAGTAC
AGAAAACTGAAGGCCAGCTGTCAGGAGTCGGCCAGGATCGAGGACATGAGGAAGCGGCAT
GTCGAGGTCTCCCAGGCCCCCTTGCCCCCCGCCCCTGCCTACCTCTCCTCTCCCCTGGCC
CTGCCCAGTCAGAGGAGGAGGCCCCCAGAGGAGCCACCTGACTTCTGCTGTCCCAAGTGC
CAGTATCAGGCCCCTGATATGGACACCCTGCAGATACATGTCATGGAGTGCATTGAGTAG

Target 22 GenBank Gene ID

Not Available

Target 22 GeneCard ID

IKBKG

Target 22 GenAtlas ID

IKBKG

Target 22 HGNC ID

HGNC:5961

Target 22 Chromosome Location

Not Available

Target 22 Locus

Not Available

Target 22 SNPs

SNPJam Report Link Image

Target 22 Toxin References

R223 - Kaphalia BS, Ansari GA: Covalent binding of ethylene dibromide and its metabolites to albumin. Toxicol Lett. 1992 Sep;62(2-3):221-30. [PubMed ]

Target 22 General References

9927690; 10087442; 9751060; 10839543; 10944468; 15489334; 9891086; 10364167; 11064457

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.