id,name,created_at,updated_at,uniprot,description,genesequence,proteinsequence,gene_name,synonyms,number_of_residues,molecular_weight,theoretical_pi,go_classification,general_function,domain_function,hgnc_id,cellular_location,genbank_id,pathway,reaction,signals,transmembrane_regions,essentiality,pdb_id,genecard_id,genatlas_id,genbank_id_gene,chromosome_location,locus 2,"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial",2009-03-06 21:37:32 UTC,2009-06-30 03:51:39 UTC,P29803,"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)","",">Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial MLAAFISRVLRRVAQKSARRVLVASRNSSNDATFEIKKCDLYLLEEGPPVTTVLTRAEGLKYYRMMLTVR RMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHGVCYTRGLSVRSILAELTGRR GGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACKYKGNDEICLTLYGDGAANQGQIAEAFNMAA LWKLPCVFICENNLYGMGTSTERAAASPDYYKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILM ELQTYRYHGHSMSDPGVSYRTREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQF ATTDPEPHLEELGHHIYSSDSSFEVRGANPWIKFKSVS",PDHA2,PDHE1-A type II,388,42934,8.56,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Energy production and conversion,PF00676:E1_dh,HGNC:8807,Mitochondrion matrix,"","","",None,None,Non Essential,"",PDHA2,PDHA2,BC127638,"","" 3,Hemoglobin subunit beta,2009-03-30 19:57:52 UTC,2009-06-30 03:51:47 UTC,P68871,"LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure","",">Hemoglobin subunit beta MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLG AFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVAN ALAHKYH",HBB,Hemoglobin beta chain; Beta-globin; Contains: RecName: LVV-hemorphin-7,147,15999,7.32,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4827,"",,"","",None,None,Non Essential,1DXT,HBB,HBB,L48932,Chromosome:11,11p15.5 4,Hemoglobin subunit alpha,2009-03-31 23:06:30 UTC,2009-06-30 03:51:44 UTC,P69905,Involved in oxygen transport from the lung to the various peripheral tissues,"",">Hemoglobin subunit alpha MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNA VAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSK YR",HBA1,Hemoglobin alpha chain; Alpha-globin,142,15258,9.09,">>> Function: oxygen binding Function: binding || >>> Process: gas transport Process: oxygen transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4823,"",,"","",None,None,Non Essential,1Y01,HBA1,HBA1,BC101848,Chromosome:16,16p13.3 5,Estrogen receptor,2009-04-01 00:20:35 UTC,2009-06-30 03:51:47 UTC,P03372,Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues,"",">Estrogen receptor MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANA QVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYT VREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFK RSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEV GSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLA DRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLM AKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASV EETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV",ESR1,ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1,595,66217,8.14,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF02159:Oest_recep PF00105:zf-C4",HGNC:3467,Nucleus,,"","",None,None,Non Essential,1R5K,ESR1,ESR1,Z75126,"","" 6,Glucocorticoid receptor,2009-04-01 00:23:57 UTC,2009-06-30 03:51:37 UTC,P04150,"Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity)","",">Glucocorticoid receptor MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSV SNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPK SSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNE SPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEK EDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPI FNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEA RKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIM TTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIIN EQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKA IVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIK KLLFHQK",NR3C1,GR; Nuclear receptor subfamily 3 group C member 1,777,85660,6.31,">>> Function: transcription factor activity Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: glucocorticoid receptor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF02155:GCR PF00104:Hormone_recep PF00105:zf-C4",HGNC:7978,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1NHZ,NR3C1,NR3C1,S68378,"","" 7,"Glutathione reductase, mitochondrial",2009-04-01 00:33:59 UTC,2009-06-30 03:51:46 UTC,P00390,Maintains high levels of reduced glutathione in the cytosol,"",">Glutathione reductase, mitochondrial MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVI GGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNW RVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHES QIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTE ELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQ TDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQG FAVAVKMGATKADFDNTVAIHPTSSEELVTLR",GSR,GRase; GR,522,56258,8.66,">>> Function: disulfide oxidoreductase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: catalytic activity Function: oxidoreductase activity Function: transporter activity Function: electron transporter activity Function: glutathione-disulfide reductase activity || >>> Process: generation of precursor metabolites and energy Process: electron transport Process: physiological process Process: metabolism Process: cellular metabolism Process: cofactor metabolism Process: coenzyme metabolism Process: glutathione metabolism || >>> Component: cell Component: intracellular Component: cytoplasm",RNA processing and modification,"PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim",HGNC:4623,Mitochondrion. Cytoplasm,,"","",None,None,Non Essential,1BWC,GSR,GSR,BC069244,"","" 8,Kelch-like ECH-associated protein 1,2009-04-01 16:08:39 UTC,2009-06-30 03:51:38 UTC,Q14145,"Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome","",">Kelch-like ECH-associated protein 1 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNEL RLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFA YTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMH FGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNF LQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDG TWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECY YPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGIT VHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC",KEAP1,Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19,624,69667,6.42,">>> Function: binding Function: protein binding || >>> Process: Not Available || >>> Component: Not Available","","PF07707:BACK PF00651:BTB PF01344:Kelch_1",HGNC:23177,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1U6D,KEAP1,KEAP1,BC015945,Chromosome:19,19p13.2 9,Poly [ADP-ribose] polymerase 1,2009-04-01 16:10:46 UTC,2009-06-30 03:51:45 UTC,P09874,"Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks","",">Poly [ADP-ribose] polymerase 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVE VDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLS KKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKG DEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAIL DRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKV KKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPV EVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLV DIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN FTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGK LSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLD IEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHT SQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVN DTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW",PARP1,PARP-1; ADPRT; NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1,1014,113085,9.34,">>> Function: NAD+ ADP-ribosyltransferase activity Function: NAD+ ADP-ribosyltransferase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring pentosyl groups Function: NAD+ ADP-ribosyltransferase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid ADP-ribosylation Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: cell Component: intracellular","","PF00533:BRCT PF08063:PADR1 PF00644:PARP PF02877:PARP_reg PF05406:WGR PF00645:zf-PARP",HGNC:270,Nucleus,,"","",None,None,Non Essential,1WOK,PARP1,PARP1,M17081,"","" 10,Thioredoxin,2009-04-01 16:13:26 UTC,2009-06-30 03:51:44 UTC,P10599,ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55),"",">Thioredoxin MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECE VKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV",TXN,Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP,105,11738,4.55,">>> Function: transporter activity Function: electron transporter activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00085:Thioredoxin,HGNC:12435,Cytoplasm,,"","",None,None,Non Essential,1ERU,TXN,TXN,BC054866,"","" 11,Tubulin beta chain,2009-04-01 16:15:58 UTC,2009-06-30 03:51:47 UTC,P07437,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin beta chain MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEP GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK TAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEEEDFGEEAEEEA",TUBB,Tubulin beta-5 chain,444,49671,4.52,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20778,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB,TUBB,BC070326,"","" 12,"Actin, cytoplasmic 1",2009-04-01 16:19:34 UTC,2009-06-30 03:51:40 UTC,P60709,Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells,"",">Actin, cytoplasmic 1 MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYP IEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVL SLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVR DIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFN SIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLS TFQQMWISKQEYDESGPSIVHRKCF",ACTB,Beta-actin,375,41737,5.15,">>> Function: binding Function: protein binding Function: structural molecule activity Function: structural constituent of cytoskeleton Function: motor activity || >>> Process: Not Available || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: actin cytoskeleton Component: actin filament",Cytoskeleton,PF00022:Actin,HGNC:132,"Cytoplasm, cytoskeleton",,"","",None,None,Non Essential,1HLU,ACTB,ACTB,V00478,"","" 13,Ig heavy chain V-I region WOL,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P01760,"","",">Ig heavy chain V-I region WOL QVQLMQSGAEVKKPGSSVRVSCKTSGGTFVDYKGLWVRQAPGKGLEWVGQIPLRFNGEVKNPGSVVRVSV SLKPSFNQAHMELSSLFSEDTAVYYCAREYGFDTSDYYYYYWGQGTLVTVSSGS","","",124,13684,8.63,"","",PF00047:ig,"","",,"","",None,None,Non Essential,"","","","","","" 14,Ig kappa chain V-I region Roy,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P01608,"","",">Ig kappa chain V-I region Roy DIQMTQSPSSLSASVGDRVTITCQASQDISIFLNWYQQKPGKAPKLLIYDASKLEAGVPSRFSGTGSGTD FTFTISSLQPEDIATYYCQQFDNLPLTFGGGTKVDFKR","","",108,11782,4.93,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,1B6D,"","","","","" 15,Mitogen-activated protein kinase 8,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P45983,"JNK1 isoforms display different binding patterns:beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta- 2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms","",">Mitogen-activated protein kinase 8 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRA YRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWS VGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLF PADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIE EWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA GPLGCCR",MAPK8,Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; JNK-46,427,48296,6.89,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6881,"",,REACT_578-Apoptosis;,"",None,None,Non Essential,1UKI,MAPK8,MAPK8,U35005,Chromosome:10,10q11.22 16,Protein kinase C eta type,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P24723,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters","",">Protein kinase C eta type MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYNE EFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELRGTTGASDTFEGWVDLEPEGKVFVVITLTGSF TEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVV HKRCHHLIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICK MNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRL GIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHE GHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENED DLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP FRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQP",PRKCH,nPKC-eta; PKC-L,683,77773,7.80,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9403,"",,"","",None,None,Non Essential,"",PRKCH,PRKCH,S74620,Chromosome:14,14q22-q23 17,Ribonucleoside-diphosphate reductase subunit M2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P31350,Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling,"",">Ribonucleoside-diphosphate reductase subunit M2 MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDE PLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGI VNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWA LRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHL VHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFM ENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF",RRM2,Ribonucleotide reductase small subunit; Ribonucleotide reductase small chain,389,44878,5.05,">>> Function: oxidoreductase activity, acting on CH2 groups Function: oxidoreductase activity, acting on CH2 groups, disulfide as acceptor Function: ribonucleoside-diphosphate reductase activity Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleoside diphosphate metabolism Process: deoxyribonucleoside diphosphate metabolism || >>> Component: Not Available",Nucleotide transport and metabolism,PF00268:Ribonuc_red_sm,HGNC:10452,Cytoplasm,,"","",None,None,Non Essential,1H0N,RRM2,RRM2,BC030154,"","" 18,Calmodulin,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P62158,"Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis","",">Calmodulin MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFL TMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYE EFVQMMTAK",CALM1,CaM,149,16838,3.84,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: Not Available || >>> Component: Not Available","",PF00036:efhand,HGNC:1442,Spindle,,"","",None,None,Non Essential,1IQ5,CALM1,CALM1,BC047523,Chromosome:14,14q24-q31 19,Mitogen-activated protein kinase 9,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P45984,"JNK2 isoforms display different binding patterns:alpha- 1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it","",">Mitogen-activated protein kinase 9 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRA YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIK HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWS VGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIF PSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIE EWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL EGCR",MAPK9,Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2; JNK-55,424,48140,5.34,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6886,"",,"","",None,None,Non Essential,"",MAPK9,MAPK9,BC032539,"","" 20,Glutamate [NMDA] receptor subunit 3A,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,Q8TCU5,"NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity)","",">Glutamate [NMDA] receptor subunit 3A MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAPD DSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEG LLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELD LVSLVLHIPVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFL LLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPP ELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCM EVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIV MDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSS LHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVT SFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSP FGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVG EKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLD AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRV VPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLH RAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFSDEEGQNQLGIRIHQDIPLPP RRRELPALRTTNGKADSLNVSRNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES",GRIN3A,N-methyl-D-aspartate receptor subtype NR3A; NMDAR-L,1115,125467,7.62,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00060:Lig_chan,HGNC:16767,Cell membrane,,"","",1-23,"675-695 749-769 931-951",Non Essential,"",GRIN3A,GRIN3A,AL356516,"","" 21,Cytochrome c oxidase subunit 3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P00414,"Subunits I, II and III form the functional core of the enzyme complex","",">Cytochrome c oxidase subunit 3 MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTRESTYQGH HTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLAS GVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVII GSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS",MT-CO3,Cytochrome c oxidase polypeptide III,261,29951,7.34,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane",Energy production and conversion,PF00510:COX3,HGNC:7422,Mitochondrion inner membrane,,"","",None,"15-35 42-59 81-101 127-147 159-179 197-217 239-259",Non Essential,"",MT-CO3,MT-CO3,AF004341,"Chromosome:MT   
HGNC chromosome: mitochondria","" 22,Parathyroid hormone-related protein,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P12272,Osteostatin is a potent inhibitor of osteoclastic bone resorption,"",">Parathyroid hormone-related protein MQRRLVQQWSVAVFLLSYAVPSCGRSVEGLSRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTA EIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKK RRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH",PTHLH,PTH-rP; PTHrP; Contains: RecName: PTHrP[1-36]; Contains: RecName: PTHrP[38-94]; Contains: RecName: Osteostatin; PTHrP[107-139],177,20194,10.90,">>> Function: signal transducer activity Function: receptor binding Function: hormone activity || >>> Process: physiological process Process: organismal physiological process Process: reproductive organismal physiological process Process: lactation || >>> Component: extracellular region","",PF01279:Parathyroid,HGNC:9607,Cytoplasm. Nucleus. Secreted,,"","",1-24,None,Non Essential,1BZG,PTHLH,PTHLH,M34071,Chromosome:12,12p12.1-p11.2 23,Tubulin gamma-1 chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P23258,"Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly","",">Tubulin gamma-1 chain MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLE PRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHS IAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTAL NRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQ SVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIP WGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDE MDTSREIVQQLIDEYHAATRPDYISWGTQEQ",TUBG1,Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1,451,51171,6.06,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12417,Centrosome,,"","",None,None,Non Essential,"",TUBG1,TUBG1,BC000619,Chromosome:17,17q21 24,Alcohol dehydrogenase 1B,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P00325,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase 1B MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEA AGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHH FLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVM GCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASL LCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHV LPFEKINEGFDLLHSGKSIRTVLTF",ADH1B,Alcohol dehydrogenase subunit beta,375,39855,8.38,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:250,Cytoplasm,,"","",None,None,Non Essential,1HSZ,ADH1B,ADH1B,AF040967,"","" 25,Alcohol dehydrogenase 1C,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P00326,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase 1C MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEA AGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHH FVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVM GCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASL LCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNI LPFEKINEGFDLLRSGKSIRTVLTF",ADH1C,Alcohol dehydrogenase subunit gamma,375,39868,8.38,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:251,Cytoplasm,,"","",None,None,Non Essential,1HT0,ADH1C,ADH1C,BC074786,"","" 26,Sodium/potassium-transporting ATPase alpha-1 chain,2009-04-08 04:35:11 UTC,2009-07-22 22:36:32 UTC,P05023,"This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients","",">Sodium/potassium-transporting ATPase subunit alpha-1 MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAE ILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVV IITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANG CKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGG QTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKR MARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLA LSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQL SIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFL PDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKG VGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLI IVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD NLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPK TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQ RKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRM YPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY",ATP1A1,Sodium pump subunit alpha-1; Na(+)/K(+) ATPase alpha-1 subunit,1023,112897,5.15,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: monovalent inorganic cation transporter activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: monovalent inorganic cation transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:799,Membrane,,"","",None,"88-108 132-152 289-308 321-338 773-792 803-823 844-866 919-938 952-970 986-1006",Non Essential,1MO8,ATP1A1,ATP1A1,M16794,"","" 27,Ig kappa chain V-III region SIE,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P01620,"","",">Ig kappa chain V-III region SIE EIVLTQSPGTLSLSPGERATLSCRASQSVSNSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGT DFTLTISRLEPDDFAVYYCQQYGSSPQTFGQGSKVEIKR","","",109,11775,8.68,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,1QLR,"","","","","" 28,Hypoxanthine-guanine phosphoribosyltransferase,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P00492,IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate,"",">Hypoxanthine-guanine phosphoribosyltransferase MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKG GYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTG KTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISE TGKAKYKA",HPRT1,HGPRTase; HGPRT,218,24580,6.67,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring pentosyl groups Function: hypoxanthine phosphoribosyltransferase activity || >>> Process: nucleoside metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: purine salvage Process: purine ribonucleoside salvage || >>> Component: cell Component: intracellular Component: cytoplasm",Nucleotide transport and metabolism,PF00156:Pribosyltran,HGNC:5157,Cytoplasm,,"","",None,None,Non Essential,1BZY,HPRT1,HPRT1,S60300,"","" 29,Plasma membrane calcium-transporting ATPase 4,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P23634,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell,"",">Plasma membrane calcium-transporting ATPase 4 MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKTSPVEGLSGNP ADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPE DENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGD IAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQT GIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKS VLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVA VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQI PSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEE KLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTVIEPM ACDGLRTICIAYRDFDDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNI NTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIID STVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSI SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKP LISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRK IHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIP TRSLKFLKEAGHGTTKEEITKDAEGLDEIDHAEMELRRGQILWFRGLNRIQTQIDVINTFQTGASFKGVL RRQNMGQHLDVKLVPSSSYIKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEE NPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV",ATP2B4,PMCA4; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4; Matrix-remodeling-associated protein 1,1241,137922,6.56,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:817,Cell membrane,,"","",None,"93-113 151-171 357-376 410-427 841-860 871-891 912-934 953-974 994-1015 1026-1047",Non Essential,"",ATP2B4,ATP2B4,U42378,"","" 30,Mitogen-activated protein kinase 6,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,Q16659,Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity),"",">Mitogen-activated protein kinase 6 MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIR RLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGL KYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYT KAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQ LLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSH IYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYS TEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKK GKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQL ELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLD KFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPS AMKSSPQIPHQTYSSILKHLN",MAPK6,Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK,721,82682,4.67,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6879,"",,"","",None,None,Non Essential,"",MAPK6,MAPK6,BC035492,Chromosome:15,15q21 31,Gamma-aminobutyric acid receptor subunit gamma-2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P18507,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit gamma-2 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVIL NNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSN MVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSS YGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTY IPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSAL VEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCC FEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL",GABRG2,GABA(A) receptor subunit gamma-2,467,54163,8.60,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4087,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-39,"274-296 300-322 334-356 444-466",Non Essential,"",GABRG2,GABRG2,BC074795,"","" 32,Ig heavy chain V-III region LAY,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P01775,"","",">Ig heavy chain V-III region LAY AVQLLESGGGLVQPGGSLRLSCAASGFTFSASAMSWVRQAPGKGLEWVAWKYENGNDKHYADSVNGRFTI SRNDSKNTLYLQMNGLQAZVSAIYYCARDAGPYVSPTFFAHWGQGTLVT","","",119,12857,8.69,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 33,Hemoglobin subunit epsilon,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P02100,The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin,"",">Hemoglobin subunit epsilon MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFDSFGNLSSPSAILGNPKVKAHGKKVLT SFGDAIKNMDNLKPAFAKLSELHCDKLHVDPENFKLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAI ALAHKYH",HBE1,Hemoglobin epsilon chain; Epsilon-globin,147,16203,9.10,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4830,"",,"","",None,None,Non Essential,1A9W,HBE1,HBE1,BC015537,Chromosome:11,11p15.5 34,Androgen receptor,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P10275,"Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3","",">Androgen receptor MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQ QQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAAS KGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAR EASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPT PCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGA LDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGP GSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLA GQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCL ICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARK LKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAAL LSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDR IIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGK VKPIYFHTQ",AR,Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4,919,98990,6.38,">>> Function: transcription factor activity Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: androgen receptor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF02166:Androgen_recep PF00104:Hormone_recep PF00105:zf-C4",HGNC:644,Nucleus,,"","",None,None,Non Essential,1E3G,AR,AR,U16371,"","" 35,"Cytochrome c oxidase subunit 8A, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P10176,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 8A, mitochondrial MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILSHLETYRRPE",COX8A,Cytochrome c oxidase polypeptide VIII-liver/heart; Cytochrome c oxidase subunit 8-2,69,7579,10.83,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02285:COX8,HGNC:2294,Mitochondrion inner membrane,"","","",None,37-60,Non Essential,"",COX8A,COX8A,BC063025,Chromosome:11,11q12-q13 36,Gamma-aminobutyric-acid receptor subunit alpha-1,2009-04-08 04:35:11 UTC,2009-07-22 22:35:21 UTC,P14867,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-1 MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKT DIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMT MPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAE DGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVP ARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVV PEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ",GABRA1,GABA(A) receptor subunit alpha-1,456,51802,9.61,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4075,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-27,"252-273 279-300 313-334 422-443",Non Essential,"",GABRA1,GABRA1,X14766,"","" 37,Tubulin alpha-1A chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,Q71U36,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-1A chain MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDL EPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHS FGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGVDSVEGEGEEEGEEY",TUBA1A,Tubulin B-alpha-1; Tubulin alpha-3 chain; Alpha-tubulin 3,451,50136,4.70,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20766,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA1A,TUBA1A,K00557,Chromosome:12,12q12-q14.3 38,Hemoglobin subunit gamma-1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P69891,"Gamma chains make up the fetal hemoglobin F, in combination with alpha chains","",">Hemoglobin subunit gamma-1 MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLT SLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVAS ALSSRYH",HBG1,Hemoglobin gamma-1 chain; Gamma-1-globin; Hemoglobin gamma-A chain; Hb F Agamma,147,16141,7.23,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4831,"",,"","",None,None,Non Essential,1I3E,HBG1,HBG1,BC020719,Chromosome:11,11p15.5 39,Tubulin alpha-3E chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,Q6PEY2,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin alpha-3E chain MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDL EPTVVDEVRTGTYRQLFHPEQLITGKEDAASNYARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHS FGGGTGSGFASLLMERLSVDYSKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLVHKFDLMYAKWAFVHWYVGEGMEEGEFSE AREDLAALEKDCEEVGVDSVEAEAEEGEEY",TUBA3E,Alpha-tubulin 3E,450,49917,4.73,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20765,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA3E,TUBA3E,BC057811,"","" 40,Tubulin alpha-4A chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P68366,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-4A chain MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGKHVPRAVFVDL EPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLDRIRKLSDQCTGLQGFLVFHS FGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGIDSYEDEDEGEE",TUBA4A,Tubulin alpha-1 chain; Alpha-tubulin 1; Testis-specific alpha-tubulin; Tubulin H2-alpha,448,49925,4.69,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12407,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA4A,TUBA4A,BC009238,"","" 41,Alpha-synuclein,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P37840,"May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule- associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation","",">Alpha-synuclein MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAV VTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA",SNCA,Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP,140,14460,4.37,">>> Function: Not Available || >>> Process: Not Available || >>> Component: cell Component: intracellular Component: cytoplasm","",PF01387:Synuclein,HGNC:11138,Cytoplasm. Membrane. Nucleus,,"","",None,None,Non Essential,1XQ8,SNCA,SNCA,BC108275,"","" 42,ATP-citrate synthase,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P53396,ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine,"",">ATP-citrate synthase MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLG LVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGV DVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKD GVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVA GGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNV AATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALG HRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKST TLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAM RKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIK PGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDH VLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASE TAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASF MTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNT IICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSI NNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADE YIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM",ACLY,ATP-citrate (pro-S-)-lyase; Citrate cleavage enzyme,1101,120841,7.34,">>> Function: catalytic activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Energy production and conversion,"PF02629:CoA_binding PF00549:Ligase_CoA",HGNC:115,Cytoplasm,,"","",None,None,Non Essential,"",ACLY,ACLY,BC006195,Chromosome:17,17q12-q21 43,Histone H3.1t,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q16695,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H3.1t MARTKQTARKSTGGKAPRKQLATKVARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQR LMREIAQDFKTDLRFQSSAVMALQEACESYLVGLFEDTNLCVIHAKRVTIMPKDIQLARRIRGERA",HIST3H3,H3t; H3/t; H3/g,136,15509,11.71,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:4778,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST3H3,HIST3H3,BC101839,"","" 44,Cytochrome P450 1A1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P04798,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics","",">Cytochrome P450 1A1 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQY GDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQN GLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHN HQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM TPIYGLTMKHACCEHFQMQLRS",CYP1A1,CYPIA1; P450-P1; P450 form 6; P450-C,512,58166,8.47,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2595,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP1A1,CYP1A1,AF040259,Chromosome:15,15q24.1 45,Tubulin beta-2C chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P68371,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin beta-2C chain MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEP GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK TAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEEGEFEEEAEEEVA",TUBB2C,Tubulin beta-2 chain,445,49832,4.52,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20771,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB2C,TUBB2C,BC071889,"","" 46,Peroxisome proliferator-activated receptor alpha,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q07869,"Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids","",">Peroxisome proliferator-activated receptor alpha MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITD TLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCD RSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRI YEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTS VETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKP FCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY",PPARA,PPAR-alpha; Nuclear receptor subfamily 1 group C member 1,468,52226,6.20,">>> Function: steroid hormone receptor activity Function: transcription factor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:9232,Nucleus,,"","",None,None,Non Essential,1K7L,PPARA,PPARA,AL078611,Chromosome:22,22q12-q13.1|22q13.31 47,Aquaporin-12A,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q8IXF9,Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity),"",">Aquaporin-12A MAGLNVSLSFFFATFALCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLLLTLLFLLFLA HGVTLDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLCWAWELSDLHLLQSLMAQSCS SALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFA CSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSS VREPGRSGVEGPHSS",AQP12A,AQP-12,295,31475,8.30,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane","","",HGNC:19941,Membrane,,"","",None,"1-21 55-75 100-126 146-166 179-199 216-236",Non Essential,"",AQP12A,AQP12A,AB040748,"","" 48,Cytochrome c oxidase subunit 6B2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q6YFQ2,Connects the two COX monomers into the physiological dimeric form (By similarity),"",">Cytochrome c oxidase subunit VIb isoform 2 MLDVEAQEPPKGKWSTPPFDPRFPSQNQIRNCYQNFLDYHRCLKTRTRRGKSTQPCEYYFRVYHSLCPIS WVESWNEQIKNGIFAGKI",COX6B2,"COX VIb-2; Cytochrome c oxidase subunit VIb, testis-specific isoform; Cancer/testis antigen 59; CT59",88,10529,9.25,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: mitochondrion","",PF02297:COX6B,HGNC:24380,Mitochondrion intermembrane space (By similarity),"","","",None,None,Non Essential,"",COX6B2,COX6B2,BC100902,Chromosome:19,19q13.42 49,Cytochrome c oxidase subunit 6C,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P09669,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide VIc MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGI FQSVK",COX6C,"",75,8782,10.98,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02937:COX6C,HGNC:2285,Mitochondrion inner membrane,"","","",None,14-54,Non Essential,"",COX6C,COX6C,BC000187,"","" 50,Alcohol dehydrogenase class-3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P11766,"Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione","",">Alcohol dehydrogenase class-3 MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGA GIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHY MGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGGVGLAVIMG CKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALE ACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNL SFDEINKAFELMHSGKSIRTVVKI",ADH5,Alcohol dehydrogenase class-III; Alcohol dehydrogenase 5; Alcohol dehydrogenase class chi chain; S-(hydroxymethyl)glutathione dehydrogenase; Glutathione-dependent formaldehyde dehydrogenase; GSH-FDH; FALDH; FDH,374,39725,7.54,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:253,Cytoplasm,,"","",None,None,Non Essential,1MC5,ADH5,ADH5,BC014665,"","" 51,Progesterone receptor,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P06401,The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues,"",">Progesterone receptor MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPS DEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSW CLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPV KPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRV ALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASS TPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLL PRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFE SLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQA GMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIY AGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKH VSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMS EVIAAQLPKILAGMVKPLLFHKK",PGR,PR; Nuclear receptor subfamily 3 group C member 3,933,98982,6.45,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF02161:Prog_receptor PF00105:zf-C4",HGNC:8910,Nucleus,,"","",None,None,Non Essential,1SQN,PGR,PGR,AY525610,Chromosome:11,11q22-q23 52,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q15119,"Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism","",">[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINL LPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDT YGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKL LCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALG EEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSME GFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS",PDK2,Pyruvate dehydrogenase kinase isoform 2,407,46154,6.59,">>> Function: kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: physiological process Process: metabolism Process: cellular metabolism Process: phosphorus metabolism Process: phosphate metabolism Process: phosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF02518:HATPase_c,HGNC:8810,Mitochondrion matrix,,"","",None,None,Non Essential,1JM6,PDK2,PDK2,BC040478,Chromosome:17,17q21.33 53,Gamma-aminobutyric acid receptor subunit rho-2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P28476,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission","",">Gamma-aminobutyric acid receptor subunit rho-2 MPYFTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLRVDEHDFSMRP AFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRLVKKIWVPDVFF VHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYW KNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW VSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTT VQERKERKLREKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAA RKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVFS",GABRR2,GABA(A) receptor subunit rho-2,465,54152,9.58,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4091,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-20,"262-285 289-311 323-345 444-465",Non Essential,"",GABRR2,GABRR2,BC130354,"","" 54,Protein kinase C gamma type,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P05129,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters","",">Protein kinase C gamma type MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCS FVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHR RCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQ KTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQ EEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISD FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDA EGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDE EELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPP FRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM",PRKCG,PKC-gamma,697,78449,7.49,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9402,"",,"","",None,None,Non Essential,"",PRKCG,PRKCG,Z15114,Chromosome:19,19q13.4 55,Aquaporin-4,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P55087,Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system,"",">Aquaporin-4 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDM VLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPS VVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGA SMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEV EDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSV",AQP4,AQP-4; WCH4; Mercurial-insensitive water channel; MIWC,323,34830,7.75,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:637,Membrane,,"","",None,"37-57 65-85 116-136 156-176 185-205 232-252",Non Essential,"",AQP4,AQP4,BC022286,Chromosome:18,18q11.2-q12.1 56,DNA topoisomerase 2-beta,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q02880,Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks,"",">DNA topoisomerase 2-beta MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDT YIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIW NNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHS FKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNG KKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYV VDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLA VSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIM TDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHG LPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAG SVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPML PNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKE YHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSY YGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAE EDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLA AFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK KKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVK KRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKAS PITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEED SASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGK GRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYF AESDEEEDDVDFAMFN",TOP2B,"DNA topoisomerase II, beta isozyme",1626,183269,8.16,">>> Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: DNA topoisomerase activity Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: nucleic acid binding Function: DNA binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: DNA topological change Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism || >>> Component: Not Available","Replication, recombination and repair","PF00204:DNA_gyraseB PF00521:DNA_topoisoIV PF08070:DTHCT PF02518:HATPase_c",HGNC:11990,"Cytoplasm. Nucleus, nucleolus",,"","",None,None,Non Essential,"",TOP2B,TOP2B,U54831,"","" 57,"Cytochrome c oxidase subunit 4 isoform 2, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q96KJ9,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase subunit 4 isoform 2, mitochondrial MLPRAAWSLVLRKGGGGRRGMHSSEGTTRGGGKMSPYTNCYAQRYYPMPEEPFCTELNAEEQALKEKEKG SWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVIWWQRVYVFPPKPITLTDERK AQQLQRMLDMKVNPVQGLASRWDYEKKQWKK",COX4I2,Cytochrome c oxidase subunit IV isoform 2; COX IV-2,171,20010,10.13,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02936:COX4,HGNC:16232,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",COX4I2,COX4I2,BC057779,Chromosome:20,20q11.21 58,DNA repair protein XRCC1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P18887,Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents,"",">DNA repair protein XRCC1 MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEV LVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDS PFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPGALFFSRINKTSPVTASDPAGPS YAAATLQASSAASSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTR TPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYR PDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSRRYLMAGPGSSSEEDEASHSGG SGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKAASPVLQEDIDIEGVQSEGQDNGAEDSGDTED ELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERR KLIRYVTAFNGELEDYMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPHQLYGVV PQA",XRCC1,X-ray repair cross-complementing protein 1,633,69526,6.33,">>> Function: binding Function: nucleic acid binding Function: DNA binding Function: damaged DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA repair Process: single strand break repair || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: cell Component: intracellular","","PF00533:BRCT PF01834:XRCC1_N",HGNC:12828,Nucleus,,"","",None,None,Non Essential,1XNT,XRCC1,XRCC1,AC018758,Chromosome:19,19q13.2 59,Plasma membrane calcium-transporting ATPase 1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P20020,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell,"",">Plasma membrane calcium-transporting ATPase 1 MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEG LSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEV SVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADI TVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGV NSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKK KANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFF IIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQA YINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGLLLDLKRDY QDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRD DIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRA GITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSP TDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVK AVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTES LLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFV LMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMG TLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQMDV VNAFQSGSSIQGALRRQPSIASQHHDVTNISTPTHIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRI EDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL",ATP2B1,PMCA1; Plasma membrane calcium pump isoform 1; Plasma membrane calcium ATPase isoform 1,1258,138757,5.88,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:814,Cell membrane,,"","",None,"98-118 155-175 367-386 420-437 853-872 883-903 924-946 965-986 1006-1027 1038-1059",Non Essential,"",ATP2B1,ATP2B1,U15687,Chromosome:12,12q21.3 60,"Cytochrome c oxidase polypeptide 7A2, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P14406,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 7A2, mitochondrial MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMILTVGGTAYAI YELAVASFPKKQE",COX7A2,Cytochrome c oxidase polypeptide VIIa-liver/heart; Cytochrome c oxidase subunit VIIa-L; VIIaL,83,9396,10.27,">>> Function: transporter activity Function: electron transporter activity Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02238:COX7a,HGNC:2288,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",COX7A2,COX7A2,BC101828,"","" 61,Protein kinase C epsilon type,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q02156,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters","",">Protein kinase C epsilon type MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFV TDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPK DNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHK RCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNV HRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTS PCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVN GGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILN GVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWL SKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQ DFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP",PRKCE,nPKC-epsilon,737,83675,7.13,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9401,"",,"","",None,None,Non Essential,"",PRKCE,PRKCE,BC109034,"","" 62,C-jun-amino-terminal kinase-interacting protein 4,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,O60271,The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction,"",">C-jun-amino-terminal kinase-interacting protein 4 MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQE HQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYAD QISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLP AGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPAST ANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPE LDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDD DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLF SSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYR QVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKT RDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKV LIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQ TGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGC LYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSI RCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTY QHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVI RVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGNE",SPAG9,JNK-interacting protein 4; JIP-4; JNK-associated leucine-zipper protein; JLP; Sperm-associated antigen 9; Mitogen-activated protein kinase 8-interacting protein 4; Human lung cancer protein 6; HLC-6; Proliferation-inducing protein 6; Sperm-specific protein; Sperm surface protein; Protein highly expressed in testis; PHET; Sunday driver 1; Cancer/testis antigen 89; CT89,1321,146207,4.79,"",Transcription,"",HGNC:14524,Isoform 5:Acrosome,,"","",None,None,Non Essential,"",SPAG9,SPAG9,AY219898,Chromosome:17,17q21.33 63,Alcohol dehydrogenase 1A,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P07327,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase 1A MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVTPLPVILGHEA AGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTLQDGTSRFTCRRKPIHH FLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAIM GCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASL LCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHV LPFEKINEGFDLLHSGKSIRTILMF",ADH1A,Alcohol dehydrogenase subunit alpha,375,39859,8.02,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:249,Cytoplasm,,"","",None,None,Non Essential,1HSO,ADH1A,ADH1A,M37066,"","" 64,C-jun-amino-terminal kinase-interacting protein 1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,Q9UQF2,"The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response","",">C-jun-amino-terminal kinase-interacting protein 1 MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRP PRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQ GQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEH ICLSDELPPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEE IYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGG GWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVS SPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIINGEEQE QTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKN SDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEA KGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVE YTCPTEDIYLE",MAPK8IP1,JNK-interacting protein 1; JIP-1; JNK MAP kinase scaffold protein 1; Islet-brain 1; IB-1; Mitogen-activated protein kinase 8-interacting protein 1,711,77525,4.61,"","","PF00640:PID PF00018:SH3_1",HGNC:6882,"Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity)",,"","",None,None,Non Essential,"",MAPK8IP1,MAPK8IP1,AF007134,Chromosome:11,11p12-p11.2 65,Gamma-aminobutyric acid receptor subunit gamma-1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,Q8N1C3,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit gamma-1 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNS LLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMV GKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYG YPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIP CILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALME YGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL",GABRG1,GABA(A) receptor subunit gamma-1,465,53596,8.23,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4086,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-35,"273-294 299-320 332-354 445-465",Non Essential,"",GABRG1,GABRG1,BC031087,"","" 66,Glutathione peroxidase 2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P18283,"Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors","",">Glutathione peroxidase 2 MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQ FGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLI IWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI",GPX2,GSHPx-2; GPx-2; Glutathione peroxidase-gastrointestinal; GSHPx-GI; Glutathione peroxidase-related protein 2; Gastrointestinal glutathione peroxidase; GPRP,190,21954,7.93,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4554,Cytoplasm,,"","",None,None,Non Essential,"",GPX2,GPX2,BC067221,Chromosome:14,14q24.1 67,Estrogen-related receptor gamma,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P62508,Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity),"",">Estrogen-related receptor gamma MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSS TMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHY GVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKY KRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVII GWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL QLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMT LPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV",ESRRG,Estrogen receptor-related protein 3; ERR gamma-2; Nuclear receptor subfamily 3 group B member 3,458,51307,6.44,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:3474,Nucleus (Probable),,"","",None,None,Non Essential,1VJB,ESRRG,ESRRG,AF117255,"","" 68,Potassium voltage-gated channel subfamily H member 7,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,Q9NS40,Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly,"",">Potassium voltage-gated channel subfamily H member 7 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLH GPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFEYVTDNENAAT PERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDPDVVVIDSSKHSDDSVAMKHFKSPTKESCSP SEADDTKALIQPSKCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIE GFGVHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSS PPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIY TAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAI HYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLSMCIFA LNAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGF GNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRL EEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHALQGD TLVHCGDVLTALYFLSRGSIEISKNDMVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQRED LLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDP EDSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKASGLDFEETVPTSGRMHID KRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESDLTYGEVEQRLDLLQEQLNRLESQMT TDIQTILQLLQKQTTVVPPAYSMVTAGSEYQRPIIQLMRTSQPEASIKTDRSFSPSSQCPEFLDLEKSKL KSKESLSSGVHLNTASEDNLTSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGLHRHVSD PGLPGK",KCNH7,Voltage-gated potassium channel subunit Kv11.3; Ether-a-go-go-related gene potassium channel 3; HERG-3; Ether-a-go-go-related protein 3; Eag-related protein 3,1196,135014,7.77,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans",HGNC:18863,Membrane,,"","",None,"413-433 450-470 495-515 522-542 550-570 642-662",Non Essential,"",KCNH7,KCNH7,AF032897,"","" 69,Cytochrome c oxidase subunit 6B1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P14854,Connects the two COX monomers into the physiological dimeric form (By similarity),"",">Cytochrome c oxidase subunit VIb isoform 1 MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRVYQSLCPTSWV TDWDEQRAEGTFPGKI",COX6B1,COX VIb-1,86,10192,7.13,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: mitochondrion","",PF02297:COX6B,HGNC:2280,Mitochondrion intermembrane space (By similarity),"","","",None,None,Non Essential,1V55,COX6B1,COX6B1,X58139,Chromosome:19,19q13.1 70,Cytochrome c oxidase subunit 2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P00403,Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1,"",">Cytochrome c oxidase subunit 2 MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPA IILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDN RVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIV LELIPLKIFEMGPVFTL",MT-CO2,Cytochrome c oxidase polypeptide II,227,25565,4.44,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: copper ion binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: organelle membrane Component: organelle inner membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Energy production and conversion,"PF00116:COX2 PF02790:COX2_TM",HGNC:7421,Mitochondrion inner membrane,,"","",None,"27-48 63-82",Non Essential,"",MT-CO2,MT-CO2,X55654,"Chromosome:MT   
HGNC chromosome: mitochondria","" 71,Glutathione peroxidase 6,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P59796,2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O,"",">Glutathione peroxidase 6 MFQQFQASCLVLFFLVGFAQQTLKPQNRKVDCNKGVTGTIYEYGALTLNGEEYIQFKQFAGKHVLFVNVA AYUGLAAQYPELNALQEELKNFGVIVLAFPCNQFGKQEPGTNSEILLGLKYVCPGSGFVPSFQLFEKGDV NGEKEQKVFTFLKNSCPPTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMHWFHQAPVSTVKSD ILEYLKQFNTH",GPX6,"",221,24971,6.66,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4558,Secreted (By similarity),,"","",1-19,None,Non Essential,"",GPX6,GPX6,DQ088982,"","" 72,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,Q15118,"Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism","",">[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNA CEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTD TVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSP SHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFEL FKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAV PLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDW CVPSREPKDMTTFRSA",PDK1,Pyruvate dehydrogenase kinase isoform 1,436,49245,9.05,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF02518:HATPase_c,HGNC:8809,Mitochondrion matrix,,"","",None,None,Non Essential,"",PDK1,PDK1,BC039158,"","" 73,Protein kinase C beta type,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P05771,"This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking (By similarity)","",">Protein kinase C beta type MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVC CFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVH KRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQ KTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQ EEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGK GSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE NIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF DKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEFVINV",PRKCB,PKC-beta; PKC-B,671,76870,7.00,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9395,Cytoplasm (By similarity). Membrane,,REACT_604-Hemostasis;,"",None,None,Non Essential,"",PRKCB,PRKCB,X05971,Chromosome:16,16p11.2 74,Tubulin beta-6 chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q9BUF5,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-6 chain MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEP GTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVVRKECEHCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDARNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQSKNSSYFVEWIPNNVK VAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVS EYQQYQDATANDGEEAFEDEEEEIDG",TUBB6,"",446,49858,4.51,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20776,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB6,TUBB6,BC002654,Chromosome:18,18p11.21 75,Mitogen-activated protein kinase 13,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,O15264,Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K,"",">Mitogen-activated protein kinase 13 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVG CIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQ AADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFS PIARKDSRRRSGMKL",MAPK13,Stress-activated protein kinase 4; Mitogen-activated protein kinase p38 delta; MAP kinase p38 delta,365,42090,8.66,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6875,"",,"","",None,None,Non Essential,"",MAPK13,MAPK13,BC004428,"","" 76,Histone H3.3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P84243,"Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H3.3 MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQR LVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA",H3F3A,"",136,15328,11.83,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:4764,Nucleus,,"","",None,None,Non Essential,1EQZ,H3F3A,H3F3A,BC108701,"","" 77,Hemoglobin subunit mu,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q6B0K9,"","",">Hemoglobin subunit mu MLSAQERAQIAQVWDLIAGHEAQFGAELLLRLFTVYPSTKVYFPHLSACQDATQLLSHGQRMLAAVGAAV QHVDNLRAALSPLADLHALVLRVDPANFPLLIQCFHVVLASHLQDEFTVQMQAAWDKFLTGVAVVLTEKY R",HBM,Hemoglobin mu chain; Mu-globin,141,15618,6.62,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4826,"",,"","",None,None,Non Essential,"",HBM,HBM,BC035682,Chromosome:16,16p13.3 78,Hemoglobin subunit delta,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P02042,Involved in oxygen transport from the lung to the various peripheral tissues,"",">Hemoglobin subunit delta MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFESFGDLSSPDAVMGNPKVKAHGKKVLG AFSDGLAHLDNLKGTFSQLSELHCDKLHVDPENFRLLGNVLVCVLARNFGKEFTPQMQAAYQKVVAGVAN ALAHKYH",HBD,Hemoglobin delta chain; Delta-globin,147,16056,8.26,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4829,"",,"","",None,None,Non Essential,1SI4,HBD,HBD,BC070282,Chromosome:11,11p15.5 79,Aquaporin-6,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q13520,"Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism (By similarity)","",">Aquaporin-6 MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAV QVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINVVRNSVS TGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKF TVHWVFWVGPLMGALLASLIYNFVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEME SV",AQP6,AQP-6; Aquaporin-2-like; Kidney-specific aquaporin; hKID,282,29371,8.86,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:639,Cytoplasmic vesicle membrane,,"","",None,"31-48 55-73 100-121 142-162 169-188 215-236",Non Essential,"",AQP6,AQP6,U48408,Chromosome:12,12q13 80,Porphobilinogen deaminase,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P08397,Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps,"",">Porphobilinogen deaminase MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSK IGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEK SVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGWHNRVGQILHPEE CMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTG GVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNI LDVARQLNDAH",HMBS,PBG-D; Pre-uroporphyrinogen synthase; Hydroxymethylbilane synthase; HMBS,361,39331,7.19,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: hydroxymethylbilane synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,"PF01379:Porphobil_deam PF03900:Porphobil_deamC",HGNC:4982,Cytoplasm (Probable),,"","",None,None,Non Essential,"",HMBS,HMBS,S60381,Chromosome:11,11q23.3 81,"Cytochrome c oxidase subunit 7B2, mitochondrial ",2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q8TF08,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 7B2, mitochondrial MFPLARNALSSLKIQSILQSMARHSHVKHSPDFHDKYGNAVLASGTAFCVATWVFTATQIGIEWNLSPVG RVTPKEWKHQ",COX7B2,Cytochrome c oxidase polypeptide VIIb2,80,8946,10.37,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane Component: organelle membrane Component: organelle inner membrane Component: mitochondrial inner membrane Component: mitochondrial electron transport chain","",PF05392:COX7B,HGNC:24381,Mitochondrion inner membrane (By similarity),"","","",None,33-59,Non Essential,"",COX7B2,COX7B2,BC107855,"","" 82,Mitogen-activated protein kinase 11,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q15759,"Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2","",">Mitogen-activated protein kinase 11 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKY IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVG CIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPL AIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKP PEPPKPPGSLEIEQ",MAPK11,Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; p38-2; Stress-activated protein kinase 2,364,41358,5.64,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","","",HGNC:6873,"",,"","",None,None,Non Essential,"",MAPK11,MAPK11,BC027933,Chromosome:22,22q13.33 83,Uteroglobin,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P11684,"Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2","",">Uteroglobin MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLP QKPRESIIKLMEKIAQSSLCN",SCGB1A1,Secretoglobin family 1A member 1; Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; Urinary protein 1; Urine protein 1; UP1,91,9994,4.71,">>> Function: binding Function: steroid binding || >>> Process: Not Available || >>> Component: Not Available","",PF01099:Uteroglobin,HGNC:12523,Secreted,,"","",1-21,None,Non Essential,"",SCGB1A1,SCGB1A1,X59875,Chromosome:11,11q12.3-q13.1 84,Plasma membrane calcium-transporting ATPase 3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q16720,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell,"",">Plasma membrane calcium-transporting ATPase 3 MGDMANSSIEFHPKPQQQRDVPQAGGFGCTLAELRTLMELRGAEALQKIEEAYGDVSGLCRRLKTSPTEG LADNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNV SGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAA LVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVG VNSQTGIIFTLLGAGGEEEEKKDKKGKQQDGAMESSQTKAKKQDGAVAMEMQPLKSAEGGEMEEREKKKA NAPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVEGRTWLAECTPVYVQYFVKFFII GVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYL GDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFVLDLKRDFQP VREQIPEDKLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDM VRKIIEPMACDGLRTICIAYRDFSAGQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGIT VRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDK HTLVKGIIDSTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVM WGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLL RKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNTFVMMQ LFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELV WGQVIATIPTSQLKCLKEAGHGPGKDEMTDEELAEGEEEIDHAERELRRGQILWFRGLNRIQTQIRVVKA FRSSLYEGLEKPESKTSIHNFMATPEFLINDYTHNIPLIDDTDVDENEERLRAPPPPSPNQNNNAIDSGI YLTTHVTKSATSSVFSSSPGSPLHSVETSL",ATP2B3,PMCA3; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium pump isoform 3,1220,134199,5.29,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:816,Cell membrane,,"","",None,"98-118 156-176 365-384 418-435 850-869 880-900 921-943 962-983 1003-1024 1035-1056",Non Essential,"",ATP2B3,ATP2B3,U15690,"","" 85,Ig kappa chain C region,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P01834,"","",">Ig kappa chain C region TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC",IGKC,"",106,11609,5.68,"","",PF07654:C1-set,HGNC:5716,"",,"","",None,None,Non Essential,1N8Z,IGKC,IGKC,J00241,"","" 86,Thioredoxin reductase 3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,Q86VQ6,"Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)","",">Thioredoxin reductase 3 MGHVHRLVSGKRRMHLTSRPVASTHSPLILDMCPHLNNGPMTGCGRAGDPISHARGGAGGRGERLPRGFA RVVRVASEGSVRRPSGPVPAPQPPAFRFVSRPGRARSESETLERSPPQSPGPGKAGDAPNRRSGHVRGAR VLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELD QVDDGARVQEVLSEITNQKTVPNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGL SCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVR HNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERP RYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEK VGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKIGLEKI GVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVF TPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNA GEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG",TXNRD3,Thioredoxin reductase TR2; Thioredoxin and glutathione reductase,754,82465,8.80,">>> Function: oxidoreductase activity, acting on NADH or NADPH Function: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor Function: disulfide oxidoreductase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: catalytic activity Function: oxidoreductase activity Function: transporter activity Function: electron transporter activity || >>> Process: homeostasis Process: cell homeostasis Process: cell redox homeostasis Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: intracellular Component: cytoplasm",Energy production and conversion,"PF00462:Glutaredoxin PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim",HGNC:20667,Cytoplasm (By similarity). Nucleus (By similarity). Microsome (By similarity). Endoplasmic reticulum (By similarity),,"","",None,None,Non Essential,"",TXNRD3,TXNRD3,AF133519,"","" 87,Alcohol dehydrogenase 6,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P28332,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase 6 MSTTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKVLGSKHLDLLYPTILGHE GAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQSKTQLMSDGTSRFTCKGKSIYH FGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFSTGFGAAINTAKVTPGSTCAVFGLGGVGLSVVM GCKAAGAARIIGVDVNKEKFKKAQELGATECLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDVLAAAL ASCNESYGVCVVVGVLPASVQLKISGQLFFSGRSLKGSVFGGWKSRQHIPKLVADYMAEKLNLDPLITHT LNLDKINEAVELMKTGKW",ADH6,"",368,39073,7.86,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:255,Cytoplasm,,"","",None,None,Non Essential,"",ADH6,ADH6,AY962311,"","" 88,"Cytochrome c oxidase subunit 6A2, mitochondrial ",2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,Q02221,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 6A2, mitochondrial MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLHSGHRPRPEFRPYQHLRIRTK PYPWGDGNHTLFHNSHVNPLPTGYEHP",COX6A2,Cytochrome c oxidase polypeptide VIa-heart; COXVIAH,97,10816,11.37,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: envelope Component: organelle envelope Component: mitochondrial envelope","",PF02046:COX6A,HGNC:2279,Mitochondrion inner membrane,"","","",None,None,Non Essential,"",COX6A2,COX6A2,BC029818,Chromosome:16,16p 89,Aquaporin-11,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,Q8NBQ7,Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity),"",">Aquaporin-11 MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVAHAFVLEFLATFQLCCCTHELQLLSEQ HPAHPTWTLTLVYFFSLVHGLTLVGTSSNPCGVMMQMMLGGMSPETGAVRLLAQLVSALCSRYCTSALWS LGLTQYHVSERSFACKNPIRVDLLKAVITEAVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVYAGGSL TGAVFNPALALSLHFMCFDEAFPQFFIVYWLAPSLGILLMILMFSFFLPWLHNNHTINKKE",AQP11,AQP-11,271,30203,7.95,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane","","",HGNC:19940,Membrane,,"","",None,"15-35 42-62 75-95 164-184 195-215 235-255",Non Essential,"",AQP11,AQP11,BC040443,Chromosome:11,11q14.1 90,Sodium/potassium-transporting ATPase subunit beta-1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P05026,"This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane","",">Sodium/potassium-transporting ATPase subunit beta-1 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQD RVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFN HERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLP VQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYG ENIGYSEKDRFQGRFDVKIEVKS",ATP1B1,Sodium/potassium-dependent ATPase subunit beta-1,303,35062,8.73,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: sodium:potassium-exchanging ATPase activity || >>> Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF00287:Na_K-ATPase,HGNC:804,Membrane,,"","",None,35-62,Non Essential,"",ATP1B1,ATP1B1,X17161,"","" 91,"5-aminolevulinate synthase, erythroid-specific, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P22557,Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2),"",">5-aminolevulinate synthase, erythroid-specific, mitochondrial MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGGDSPSWAKGHC PFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQEQEQISGKVTHLIQNNMPGN YVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQ ATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYS DAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQY GALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLC DLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRR PVHFELMSEWERSYFGNMGPQYVTTYA",ALAS2,5-aminolevulinic acid synthase; Delta-aminolevulinate synthase; Delta-ALA synthetase; ALAS-E,587,64634,8.19,">>> Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity Function: N-acyltransferase activity Function: N-succinyltransferase activity Function: 5-aminolevulinate synthase activity || >>> Process: biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis Process: heme biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,"PF00155:Aminotran_1_2 PF09029:Preseq_ALAS",HGNC:397,Mitochondrion matrix,,"","",None,None,Non Essential,"",ALAS2,ALAS2,AL020991,"","" 92,Histone H4,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P62805,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H4 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDA VTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG",HIST1H4A,"",103,11368,11.91,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:4781,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H4A,HIST1H4A,BC143045,"","" 93,Tubulin beta-1 chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,Q9H4B7,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-1 chain MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEP GTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLG GGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDI CFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQ YRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVK VAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVS EYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH",TUBB1,"",451,50328,4.82,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:16257,Cytoplasmic,,"","",None,None,Non Essential,"",TUBB1,TUBB1,BC033679,Chromosome:20,20q13.32 94,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,Q9Y3Q4,Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli,"",">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSS ALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPG EDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQ AGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIII PVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSI PVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMS DVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ GKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGK KMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMR RAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPT PVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSA SPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHF HKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPG ELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHG SLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFP RAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGA RPEPVRSKLPSNL",HCN4,"",1203,129043,9.15,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08412:Ion_trans_N",HGNC:16882,Membrane,,"","",None,"267-287 294-314 341-361 369-389 421-441 465-486 497-517",Non Essential,1Q3E,HCN4,HCN4,AJ238850,Chromosome:15,15q24-q25 95,DNA polymerase subunit gamma-1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P54098,Involved in the replication of mitochondrial DNA,"",">DNA polymerase subunit gamma-1 MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLR HNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFR LLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPT LAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIRE QYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDI SSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPH PVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEW DLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLP KRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDN LAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVE AEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDF LPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAI LPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGM HGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAE KAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQRETARKSQWKKWEVVAERAWK GGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLF EEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLR KEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP",POLG,Mitochondrial DNA polymerase catalytic subunit; PolG-alpha,1239,139564,6.89,">>> Function: gamma DNA-directed DNA polymerase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed DNA polymerase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA replication || >>> Component: protein complex Component: gamma DNA polymerase complex","Replication, recombination and repair",PF00476:DNA_pol_A,HGNC:9179,Mitochondrion,,"","",None,None,Non Essential,"",POLG,POLG,BC050559,Chromosome:15,15q25 96,Eosinophil peroxidase,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P11678,Donor + H(2)O(2) = oxidized donor + 2 H(2)O,"",">Eosinophil peroxidase MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPM DLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAER CSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFP NERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRD CIPFFRSAPSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLP FDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARK IMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRA SAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRIGLDLAALNM QRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVG PLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVN CSRIPRLNLSAWRGT",EPX,EPO; Contains: RecName: Eosinophil peroxidase light chain; Contains: RecName: Eosinophil peroxidase heavy chain,715,81042,10.81,">>> Function: antioxidant activity Function: peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","",PF03098:An_peroxidase,HGNC:3423,Cytoplasmic granule,,"","",1-17,None,Non Essential,"",EPX,EPX,X14346,Chromosome:17,17q23.1 97,GTPase HRas,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P01112,Ras proteins bind GDP/GTP and possess intrinsic GTPase activity,"",">GTPase HRas MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQ YMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIP YIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS",HRAS,Transforming protein p21; p21ras; H-Ras-1; c-H-ras; Ha-Ras,189,21298,4.94,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding || >>> Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade Process: small GTPase mediated signal transduction || >>> Component: Not Available","",PF00071:Ras,HGNC:5173,Cell membrane,,"","",None,None,Non Essential,4Q21,HRAS,HRAS,M17232,Chromosome:11,11p15.5 98,Mitogen-activated protein kinase 3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P27361,"Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4)","",">Mitogen-activated protein kinase 3 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAI KKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSN DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY LQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAM ELDDLPKERLKELIFQETARFQPGVLEAP",MAPK3,Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule-associated protein 2 kinase,379,43136,6.74,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6877,"",,REACT_1788-Transcription;,"",None,None,Non Essential,"",MAPK3,MAPK3,Z11696,Chromosome:16,16p11.2 99,Hemoglobin subunit gamma-2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P69892,"Gamma chains make up the fetal hemoglobin F, in combination with alpha chains","",">Hemoglobin subunit gamma-2 MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLT SLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTGVAS ALSSRYH",HBG2,Hemoglobin gamma-2 chain; Gamma-2-globin; Hemoglobin gamma-G chain; Hb F Ggamma,147,16127,7.23,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4832,"",,"","",None,None,Non Essential,1FDH,HBG2,HBG2,M11427,Chromosome:11,11p15.5 100,Aquaporin-5,2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,P55064,"Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions","",">Aquaporin-5 MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINP AITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTF QLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGP IVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR",AQP5,AQP-5,265,28293,8.82,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:638,Membrane,,"","",None,"13-33 37-57 88-108 127-147 162-182 206-226",Non Essential,"",AQP5,AQP5,BC032946,Chromosome:12,12q13 101,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,Q9UL51,Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity),"",">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADEGG PRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGP AEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDF RFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPE KIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQW EEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFK AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFH KLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKL KFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRL YSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDRE MVQQAELGQRVGLFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAA SPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRP ASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL",HCN2,Brain cyclic nucleotide-gated channel 2; BCNG-2,889,96951,9.21,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08412:Ion_trans_N",HGNC:4846,Membrane,,"","",None,"216-236 241-261 289-309 318-338 370-390 414-435 441-461",Non Essential,1Q3E,HCN2,HCN2,AF064877,Chromosome:19,19p13.3 102,Tubulin delta chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,Q9UJT1,"In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head (By similarity)","",">Tubulin delta chain MSIVTVQLGQCGNQIGFEVFDALLSDSHSSQGLCSMRENEAYQASCKERFFSEEENGVPIARAVLVDMEP KVINQMLSKAAQSGQWKYGQHACFCQKQGSGNNWAYGYSVHGPRHEESIMNIIRKEVEKCDSFSGFFIIM SMAGGTGSGLGAFVTQNLEDQYSNSLKMNQIIWPYGTGEVIVQNYNSILTLSHLYRSSDALLLHENDAIH KICAKLMNIKQISFSDINQVLAHQLGSVFQPTYSAESSFHYRRNPLGDLMEHLVPHPEFKMLSVRNIPHM SENSLAYTTFTWAGLLKHLRQMLISNAKMEEGIDRHVWPPLSGLPPLSKMSLNKDLHFNTSIANLVILRG KDVQSADVEGFKDPALYTSWLKPVNAFNVWKTQRAFSKYEKSAVLVSNSQFLVKPLDMIVGKAWNMFASK AYIHQYTKFGIEEEDFLDSFTSLEQVVASYCNL",TUBD1,Delta-tubulin,453,51035,6.83,">>> Function: structural molecule activity || >>> Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","",PF00091:Tubulin,HGNC:16811,"Centrosome, centriole. Cytoplasm. Nucleus",,"","",None,None,Non Essential,"",TUBD1,TUBD1,BC000258,Chromosome:17,17q23.1 103,Metal regulatory transcription factor 1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,Q14872,Activates the metallothionein I promoter. Binds to the metal responsive element (MRE),"",">Metal regulatory transcription factor 1 MGEHSPDNNIIYFEAEEDELTPDDKMLRFVDKNGLVPSSSGTVYDRTTVLIEQDPGTLEDEDDDGQCGEH LPFLVGGEEGFHLIDHEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRY QCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKA FNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHV RTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGHSYNALPQHNGSEDTNHSLCLSDLSLLSTDSEL RENSSTTQGQDLSTISPAIIFESMFQNSDDTAIQEDPQQTASLTESFNGDAESVSDVPPSTGNSASLSLP LVLQPGLSEPPQPLLPASAPSAPPPAPSLGPGSQQAAFGNPPALLQPPEVPVPHSTQFAANHQEFLPHPQ APQPIVPGLSVVAGASASAAAVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTITITPTPNTAI LQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEKVFFTTAVPVASSPGSSVQQIGLSVPVIIIKQEE ACQCQCACRDSAKERASSRRKGCSSPPPPEPSPQAPDGPSLQLPAQTFSSAPVPGSSSSTLPSSCEQSRQ AETPSDPQTETLSAMDVSEFLSLQSLDTPSNLIPIEALLQGEEEMGLTSSFSK",MTF1,Transcription factor MTF-1; MRE-binding transcription factor,753,80957,4.97,">>> Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: binding Function: nucleic acid binding || >>> Process: Not Available || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","Cell cycle control, cell division, chromosome partitioning",PF00096:zf-C2H2,HGNC:7428,Nucleus (Potential),,"","",None,None,Non Essential,"",MTF1,MTF1,BC014454,"","" 104,Steroid hormone receptor ERR2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,O95718,"","",">Steroid hormone receptor ERR2 MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGT PCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCP ATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLT KIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAW MEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALA NSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP MHKLFLEMLEAKAWARADSLQEWRPLEQVPSPLHRATKRQHVHFLTPLPPPPSVAWVGTAQAGYHLEVFL PQRAGWPRAA",ESRRB,"Estrogen-related receptor, beta; ERR-beta; Estrogen receptor-like 2; ERR beta-2; Nuclear receptor subfamily 3 group B member 2",500,55620,8.31,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:3473,Nucleus (Potential),,"","",None,None,Non Essential,"",ESRRB,ESRRB,AC008050,Chromosome:14,14q24.3 105,"Ferrochelatase, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,P22830,Catalyzes the ferrous insertion into protoporphyrin IX,"",">Ferrochelatase, mitochondrial MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTG ILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQG EGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYY NQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEV SATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDI EYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS QQL",FECH,Protoheme ferro-lyase; Heme synthetase,423,47863,8.91,">>> Function: catalytic activity Function: lyase activity Function: ferrochelatase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis Process: heme biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00762:Ferrochelatase,HGNC:3647,Mitochondrion inner membrane,,"","",None,None,Non Essential,1HRK,FECH,FECH,AF495859,Chromosome:18,18q21.3 106,Alcohol dehydrogenase 4,2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,P08319,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase 4 MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHE AAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKG KPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVG LSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSET MKAALDCTTAGWGSCTFIGVAAGSKGLTVFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDA LVTHTLPFDKISEAFDLMNQGKSIRTILIF",ADH4,Alcohol dehydrogenase class II pi chain,380,40222,8.01,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:252,Cytoplasm,,"","",None,None,Non Essential,"",ADH4,ADH4,BC022319,"","" 107,"Radical S-adenosyl methionine domain-containing protein 1, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,Q9HA92,May be involved in porphyrin cofactor biosynthesis (By similarity),"",">Radical S-adenosyl methionine domain-containing protein 1, mitochondrial MALPGARARGWAAAARAAQRRRRVENAGGSPSPEPAGRRAALYVHWPYCEKRCSYCNFNKYIPRRLEEAA MQKCLVTEAQTLLRLSGVQRVESVFFGGGTPSLASPHTVAAVLEAVAQAAHLPADLEVTLEANPTSAPGS RLAEFGAAGVNRLSIGLQSLDDTELRLLGRTHSACDALRTLAEARRLFPGRVSVDLMLGLPAQQVGPWLG QLQELLHHCDDHLSLYQLSLERGTALFAQVQRGALPAPDPELAAEMYQRGRAVLREAGFHQYEVSNFARN GALSTHNWTYWQCGQYLGVGPGAHGRFMPQGAGGHTREARIQTLEPDNWMKEVMLFGHGTRKRVPLGRLE LLEEVLALGLRTDVGITHQHWQQFEPQLTLWDVFGANKEVQELLERGLLQLDHRGLRCSWEGLAVLDSLL LTLLPQLQEAWQQRTPSPVPGG",RSAD1,Oxygen-independent coproporphyrinogen III oxidase-like protein RSAD1,442,48714,7.84,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-CH group of donors Function: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor Function: coproporphyrinogen oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis || >>> Component: cell Component: intracellular Component: cytoplasm",Coenzyme transport and metabolism,"PF06969:HemN_C PF04055:Radical_SAM",HGNC:25634,Mitochondrion (Potential),,"","",None,None,Non Essential,"",RSAD1,RSAD1,BC050538,Chromosome:17,17q21.33 108,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,P16615,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle,"",">Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAAC ISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRI KAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFS GTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFN DPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALC NDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRD RKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRC LALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGT AVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMT GDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGE VVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIG CYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCN ALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMD ETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVIWVYSTDTNFSDMFWS",ATP2A2,"SERCA2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; SR Ca(2+)-ATPase 2; Endoplasmic reticulum class 1/2 Ca(2+) ATPase",1042,114758,4.99,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: hydrogen transport Process: proton transport Process: metabolism Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:812,Endoplasmic reticulum membrane,,"","",None,"49-69 90-110 254-273 296-313 757-776 787-807 828-850 897-916 930-948 964-984",Non Essential,"",ATP2A2,ATP2A2,BC035588,Chromosome:12,12q23-q24.1 109,"Cytochrome c oxidase subunit 7C, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,P15954,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase subunit 7C, mitochondrial MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLKT",COX7C,Cytochrome c oxidase polypeptide VIIc,63,7246,10.88,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02935:COX7C,HGNC:2292,Mitochondrion inner membrane (By similarity),,"","",None,34-60,Non Essential,"",COX7C,COX7C,BC007498,"","" 110,Glutamate [NMDA] receptor subunit epsilon-4,2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,O15399,NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine,"",">Glutamate [NMDA] receptor subunit epsilon-4 MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLG PAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLP IVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDG SLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLA GGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRA QNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG RFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCID ILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETG ISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIG KSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQR PQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKD EGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKL DIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPP PPQPLPSPAYPAPGPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEA RAAPRGAAGRPLSPPAAQPPQKPPASYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAF EDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCCAAPPPCPYLDLEPSPSDSEDSES LGGASLGGLDPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLP PPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGW DLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFS SLESEV",GRIN2D,N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D; EB11,1336,143561,8.27,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","Secondary metabolites biosynthesis, transport and catabolism","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4588,Cell membrane,,"","",1-27,"584-604 657-677 845-865",Non Essential,"",GRIN2D,GRIN2D,U77783,Chromosome:19,19q13.1-qter 111,Gamma-aminobutyric-acid receptor subunit beta-2,2009-04-08 04:35:12 UTC,2009-07-22 22:35:22 UTC,P47870,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit beta-2 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIAS IDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMI RLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQF SIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGIT TVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANN EKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALER HVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN",GABRB2,GABA(A) receptor subunit beta-2,474,54607,9.66,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4082,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-25,"245-266 270-292 304-326 452-473",Non Essential,"",GABRB2,GABRB2,BC105639,"","" 112,"Phospholipid hydroperoxide glutathione peroxidase, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,P36969,Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity),"",">Phospholipid hydroperoxide glutathione peroxidase, mitochondrial MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVA SQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDA HPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF",GPX4,PHGPx; GPX-4,197,22175,8.48,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4556,Mitochondrion. Cytoplasm,,"","",None,None,Non Essential,"",GPX4,GPX4,BC039849,Chromosome:19,19p13.3 113,Ribonucleoside-diphosphate reductase large subunit,2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,P23921,Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides,"",">Ribonucleoside-diphosphate reductase large subunit MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTK HPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRD FSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGT NRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYN NTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSL MCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPE ACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSP VSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVL SGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGA FIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEK ERNTAAMVCSLENRDECLMCGS",RRM1,Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit,792,90071,7.16,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on CH2 groups Function: oxidoreductase activity, acting on CH2 groups, disulfide as acceptor Function: ribonucleoside-diphosphate reductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA replication || >>> Component: protein complex Component: ribonucleoside-diphosphate reductase complex",Nucleotide transport and metabolism,"PF03477:ATP-cone PF02867:Ribonuc_red_lgC PF00317:Ribonuc_red_lgN",HGNC:10451,Cytoplasm,,"","",None,None,Non Essential,"",RRM1,RRM1,BC006498,Chromosome:11,11p15.5 114,Plasma membrane calcium-transporting ATPase 2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,Q01814,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell,"",">Plasma membrane calcium-transporting ATPase 2 MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPG TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGG AEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVV GDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNS QTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQ QDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDT FVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETM GNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGA LPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEI VLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCI CVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEK GEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIA GTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQM LWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQID SGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFG GKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAE RELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDL EEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL",ATP2B2,PMCA2; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2,1243,136878,5.68,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:815,Cell membrane,,"","",None,"95-115 153-173 391-410 444-461 876-895 906-926 947-969 988-1009 1029-1050 1061-1082",Non Essential,"",ATP2B2,ATP2B2,U15688,"","" 115,Gamma-aminobutyric-acid receptor subunit alpha-2,2009-04-08 04:35:12 UTC,2009-07-22 22:35:22 UTC,P47869,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-2 MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFT NIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMT MPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAP DGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVP ARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVV NDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM SRIVFPVLFGTFNLVYWATYLNREPVLGVSP",GABRA2,GABA(A) receptor subunit alpha-2,451,51327,9.50,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4076,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-28,"252-273 279-300 313-334 420-441",Non Essential,"",GABRA2,GABRA2,S62907,"","" 116,"Cytochrome c oxidase polypeptide 7A1, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,P24310,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 7A1, mitochondrial MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLCLGGTVYSLYS LGWASFPRN",COX7A1,Cytochrome c oxidase polypeptide VIIa-heart; Cytochrome c oxidase subunit VIIa-H; COX VIIa-M,79,9118,10.52,">>> Function: transporter activity Function: electron transporter activity Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02238:COX7a,HGNC:2287,Mitochondrion inner membrane,,"","",None,47-75,Non Essential,"",COX7A1,COX7A1,BC002757,Chromosome:19,19q13.1 118,Radical S-adenosyl methionine domain-containing protein 2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,Q8WXG1,"Involved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus","",">Radical S-adenosyl methionine domain-containing protein 2 MWVLTPAAFAGKLLSVFRQPLSSLWRSLVPLFCWLRATFWLLATKRRKQQLVLRGPDETKEEEEDPPLPT TPTSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKEAGMEKINFSGGEPFLQDRGEYLGKLV RFCKVELRLPSVSIVSNGSLIRERWFQNYGEYLDILAISCDSFDEEVNVLIGRGQGKKNHVENLQKLRRW CRDYRVAFKINSVINRFNVEEDMTEQIKALNPVRWKVFQCLLIEGENCGEDALREAERFVIGDEEFERFL ERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCRKGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKY IWSKADLKLDW",RSAD2,"Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible; Viperin; Cytomegalovirus-induced gene 5 protein",361,42170,8.33,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity || >>> Process: Not Available || >>> Component: Not Available",Coenzyme transport and metabolism,PF04055:Radical_SAM,HGNC:30908,Endoplasmic reticulum. Golgi apparatus,,"","",None,None,Non Essential,"",RSAD2,RSAD2,BC017969,"","" 119,Mitogen-activated protein kinase 15,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,Q8TD08,"In vitro, phosphorylates MBP","",">Mitogen-activated protein kinase 15 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDH PNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKP SNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGE MLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDL LRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSS GTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQ TALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPR LPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLEGHHV",MAPK15,Extracellular signal-regulated kinase 8,544,59833,9.18,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:24667,"",,"","",None,None,Non Essential,"",MAPK15,MAPK15,BC028034,"","" 120,Aquaporin-2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,P41181,"Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient","",">Aquaporin-2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPA VTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQ LVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLV GAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA",AQP2,AQP-2; Aquaporin-CD; AQP-CD; Water channel protein for renal collecting duct; ADH water channel; Collecting duct water channel protein; WCH-CD,271,28838,6.95,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:634,Apical cell membrane,,"","",None,"17-34 41-59 86-107 128-148 157-176 203-224",Non Essential,"",AQP2,AQP2,BC042496,Chromosome:12,12q12-q13 121,Retinoic acid receptor beta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,P10826,This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression,"",">Retinoic acid receptor beta MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEE LVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRC QYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTT NSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPE QDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDK LQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGH EPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ",RARB,RAR-beta; Nuclear receptor subfamily 1 group B member 2; RAR-epsilon; HBV-activated protein,455,50490,7.86,">>> Function: retinoic acid receptor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:9865,Isoform Beta-4:Cytoplasm,,"","",None,None,Non Essential,1XDK,RARB,RARB,M57445,"","" 122,Gap junction alpha-4 protein,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,P35212,"One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell","",">Gap junction alpha-4 protein MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNVCYDQAF PISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKDPQVERALAAVERQMAKISVA EDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFI IFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPT YNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNGQKPPSRPSSSASKKQYV",GJA4,Connexin-37; Cx37,333,37415,7.61,">>> Function: transporter activity Function: channel or pore class transporter activity Function: alpha-type channel activity Function: gap-junction forming channel activity Function: connexon channel activity || >>> Process: cellular process Process: cell communication || >>> Component: protein complex Component: connexon complex","",PF00029:Connexin,HGNC:4278,Cell membrane,,"","",None,"21-40 77-99 149-165 208-230",Non Essential,"",GJA4,GJA4,BC072389,"","" 123,Gamma-aminobutyric acid receptor subunit rho-3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,A8MPY1,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (By similarity)","",">Gamma-aminobutyric acid receptor subunit rho-3 MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQKYEQLLHIEDN DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIW VPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNED DLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAIL MVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAA VNYLTTVEERKQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSS RIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV",GABRR3,GABA(A) receptor subunit rho-3,467,54272,8.26,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF02932:Neur_chan_memb,HGNC:17969,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-23,"267-287 300-320 332-352 447-467",Non Essential,"",GABRR3,GABRR3,Y18994,"","" 124,Calcineurin subunit B isoform 2,2009-04-08 04:35:12 UTC,2009-08-11 22:10:25 UTC,Q96LZ3,"Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity)","",">Calcineurin subunit B type 2 MGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHNPLVRRVIDVFDTDGDGEV DFKEFILGTSQFSVKGDEEQKLRFAFSIYDMDKDGYISNGELFQVLKMMVGNNLTDWQLQQLVDKTIIIL DKDGDGKISFEEFSAVVRDLEIHKKLVLIV",PPP3R2,Protein phosphatase 2B regulatory subunit 2; Protein phosphatase 3 regulatory subunit B beta isoform; Calcineurin B-like protein; CBLP; CNBII,170,19533,4.49,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: Not Available || >>> Component: Not Available","",PF00036:efhand,HGNC:9318,"",,"","",None,None,Non Essential,"",PPP3R2,PPP3R2,AF085237,"","" 125,Tubulin epsilon chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,Q9UJT0,"","",">Tubulin epsilon chain MTQSVVVQVGQCGNQIGCCFWDLALREHAAVNQKGIYDEAISSFFRNVDTRVVGDGGSISKGKICSLKAR AVLIDMEEGVVNEILQGPLRDVFDTKQLITDISGSGNNWAVGHKVFGSLYQDQILEKFRKSAEHCDCLQC FFIIHSMGGGTGSGLGTFLLKVLEDEFPEVYRFVTSIYPSGEDDVITSPYNSILAMKELNEHADCVLPID NQSLFDIISKIDLMVNSGKLGTTVKPKSLVTSSSGALKKQHKKPFDAMNNIVANLLLNLTSSARFEGSLN MDLNEISMNLVPFPQLHYLVSSLTPLYTLTDVNIPPRRLDQMFSDAFSKDHQLLRADPKHSLYLACALMV RGNVQISDLRRNIERLKPSLQFVSWNQEGWKTSLCSVPPVGHSHSLLALANNTCVKPTFMELKERFMRLY KKKAHLHHYLQVEGMEESCFTEAVSSLSALIQEYDQLDATKNMPVQDLPRLSIAM",TUBE1,Epsilon-tubulin,475,52933,6.62,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20775,Centrosome,,"","",None,None,Non Essential,"",TUBE1,TUBE1,BC031101,"","" 126,Glutamate [NMDA] receptor subunit zeta-1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,Q05586,"NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity)","",">Glutamate [NMDA] receptor subunit zeta-1 MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPN AIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRT VPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLME AKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAH ISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFAN YSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERV NNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQS TLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSAR ILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELS TMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQ NVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQ NQKDTVLPRRAIEREEGQLQLCSRHRES",GRIN1,N-methyl-D-aspartate receptor subunit NR1,938,105374,9.20,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4584,Cell membrane,,"","",1-18,"560-580 637-657 813-833",Non Essential,1PB7,GRIN1,GRIN1,S57708,"","" 127,Gamma-aminobutyric-acid receptor subunit rho-1,2009-04-08 04:35:12 UTC,2009-07-22 22:36:00 UTC,P24046,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission","",">Gamma-aminobutyric acid receptor subunit rho-1 MRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSE QLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFD GRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEI ESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLL QTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVF LSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQ LTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS",GABRR1,GABA(A) receptor subunit rho-1,473,55258,8.86,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4090,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-15,"276-299 303-325 337-359 452-473",Non Essential,"",GABRR1,GABRR1,AL353135,"","" 128,Thyrotropin subunit beta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,P01222,Indispensable for the control of thyroid structure and metabolism,"",">Thyrotropin subunit beta MTALFLMSMLFGLACGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQD VCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV",TSHB,Thyrotropin beta chain; Thyroid-stimulating hormone subunit beta; TSH-beta; TSH-B; Thyrotropin alfa,138,15609,7.75,">>> Function: signal transducer activity Function: receptor binding Function: hormone activity || >>> Process: Not Available || >>> Component: extracellular region","",PF00007:Cys_knot,HGNC:12372,Secreted,,"","",1-20,None,Non Essential,"",TSHB,TSHB,BC069298,"","" 129,Epididymal secretory glutathione peroxidase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,O75715,"Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathionine peroxidase-like protective system against peroxide damage in sperm membrane lipids","",">Epididymal secretory glutathione peroxidase MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYVGKHILFVNVA TYCGLTAQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDNKEILPGLKYVRPGGGFVPSFQLFEKGDV NGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIRWNFEKFLVGPDGIPVMRWSHRATVSSVKTD ILAYLKQFKTK",GPX5,Epididymis-specific glutathione peroxidase-like protein; EGLP,221,25203,8.89,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4557,Secreted,,"","",1-21,None,Non Essential,"",GPX5,GPX5,AL049543,"","" 130,Potassium voltage-gated channel subfamily H member 6,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,Q9H252,"Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly","",">Potassium voltage-gated channel subfamily H member 6 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQPCTCDFLT GPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKCS SRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPH KVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAF LLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDM VAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY AIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEK VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYT NGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLST LYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAF AESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSM GAGPCAPGHPDAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPK HRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQ RHGSDPGFAGSWGH",KCNH6,Voltage-gated potassium channel subunit Kv11.2; Ether-a-go-go-related gene potassium channel 2; Ether-a-go-go-related protein 2; Eag-related protein 2,994,109926,7.00,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF00989:PAS",HGNC:18862,Membrane,,"","",None,"262-282 299-319 341-361 371-391 399-419 491-511",Non Essential,"",KCNH6,KCNH6,BC006334,Chromosome:17,17q23.3 131,"DNA polymerase subunit gamma-2, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,Q9UHN1,"Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA","",">DNA polymerase subunit gamma-2, mitochondrial MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALL EICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLP GDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGKLRENLLHGALEHYVNCLDLVNKRLPYGLAQ IGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQD EEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYL YDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLET MQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV",POLG2,Mitochondrial DNA polymerase accessory subunit; PolG-beta; MtPolB; DNA polymerase gamma accessory 55 kDa subunit; p55,485,54912,8.48,">>> Function: glycine-tRNA ligase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: ligase activity Function: ligase activity, forming phosphoric ester bonds Function: RNA ligase activity Function: tRNA ligase activity || >>> Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: RNA metabolism Process: tRNA metabolism Process: tRNA aminoacylation Process: tRNA aminoacylation for protein translation Process: glycyl-tRNA aminoacylation Process: physiological process Process: metabolism Process: macromolecule metabolism Process: macromolecule biosynthesis Process: protein biosynthesis || >>> Component: Not Available","Translation, ribosomal structure and biogenesis",PF03129:HGTP_anticodon,HGNC:9180,Mitochondrion,,"","",None,None,Non Essential,"",POLG2,POLG2,U94703,Chromosome:17,17q 132,C-jun-amino-terminal kinase-interacting protein 3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,Q9UPT6,"The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins (By similarity)","",">C-jun-amino-terminal kinase-interacting protein 3 MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVL SENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKA KNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNV FPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSV PSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPE LDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEA IIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE HPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTAGFSQRRNHAMCPISAGSRPLEFFP DDDCTSSARREQKREQYRQVREHVRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVE KDPTMKLWCAAGVNLSGWRPNEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATS SRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATEVPDPGPSEPE TATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDPTGAGSSAAPTMWLGAQNGWL YVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIR CMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQ HLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKT SPTSGEGARPGGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQ VSYTPE",MAPK8IP3,JNK-interacting protein 3; JIP-3; JNK MAP kinase scaffold protein 3; Mitogen-activated protein kinase 8-interacting protein 3,1336,147458,5.08,"",Transcription,"",HGNC:6884,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",MAPK8IP3,MAPK8IP3,AL031717,Chromosome:16,16p13.3 133,Gamma-aminobutyric-acid receptor subunit alpha-5,2009-04-08 04:35:12 UTC,2009-07-22 22:35:21 UTC,P31644,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-5 MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGE RITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKK SIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGST KSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFW LNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWA WDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK",GABRA5,GABA(A) receptor subunit alpha-5,462,52147,9.56,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4079,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-31,"260-281 286-307 319-341 428-449",Non Essential,"",GABRA5,GABRA5,AF061785,Chromosome:15,15q11.2-q12 134,Tubulin alpha-8 chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,Q9NY65,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-8 chain MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGKHVPRAVMIDL EPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHS FGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEK AYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDLAALEKDYEEVGTDSFEEENEGEEF",TUBA8,Alpha-tubulin 8; Tubulin alpha chain-like 2,449,50094,4.70,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12410,Cytoplasmic,,"","",None,None,Non Essential,"",TUBA8,TUBA8,BC104845,Chromosome:22,22q11.1 135,Gamma-aminobutyric acid receptor subunit gamma-3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,Q99928,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit gamma-3 MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKP TVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAE AHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEA ADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKD ATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTK KTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCC YEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL",GABRG3,GABA(A) receptor subunit gamma-3,467,54289,7.58,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4088,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-17,"255-277 281-303 315-337 444-467",Non Essential,"",GABRG3,GABRG3,AF228458,Chromosome:15,15q12 136,Tubulin beta-4 chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P04350,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin beta-4 chain MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYVPRAVLVDLEP GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVK TAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEGEFEEEAEEEVA",TUBB4,Tubulin 5 beta,444,49586,4.51,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20774,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB4,TUBB4,BC013683,Chromosome:19,19p13.3 137,"HLA class II histocompatibility antigen, DRB1-11 beta chain",2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P20039,"","",">HLA class II histocompatibility antigen, DRB1-11 beta chain MVCLRLPGGSCMAVLTVTLMVLSSPLALAGDTRPRFLEYSTSECHFFNGTERVRFLDRYFYNQEEYVRFD SDVGEFRAVTELGRPDEEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVHPKVTVYPSKTQPLQH HNLLVCSVSGFYPGSIEVRWFRNGQEEKTGVVSTGLIHNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVT SPLTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPRGFLS",HLA-DRB1,MHC class I antigen DRB1*11; DRw11; DR-5; DR5,266,30160,7.20,">>> Function: Not Available || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response || >>> Component: cell Component: membrane","","PF07654:C1-set PF00969:MHC_II_beta",HGNC:4948,Membrane,,"","",1-29,228-250,Non Essential,"",HLA-DRB1,HLA-DRB1,AJ297587,"","" 138,Uroporphyrinogen decarboxylase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P06132,Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen III to yield coproporphyrinogen III,"",">Uroporphyrinogen decarboxylase MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTL QPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITL TRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAG AQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVV GLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHV GAFVDAVHKHSRLLRQN",UROD,URO-D; UPD,367,40787,6.06,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity Function: uroporphyrinogen decarboxylase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF01208:URO-D,HGNC:12591,Cytoplasm,,"","",None,None,Non Essential,1R3Y,UROD,UROD,M60891,"","" 139,Cystathionine beta-synthase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P35520,L-serine + L-homocysteine = L-cystathionine + H(2)O,"",">Cystathionine beta-synthase MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPASESPHHHTAP AKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGD TIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRL KNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGV DPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSA GSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLS APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQI RLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK",CBS,Serine sulfhydrase; Beta-thionase,551,60587,6.63,">>> Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: cystathionine beta-synthase activity || >>> Process: sulfur amino acid metabolism Process: sulfur amino acid biosynthesis Process: cysteine biosynthesis Process: cysteine biosynthesis via cystathione Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: L-serine metabolism Process: cysteine biosynthesis from serine || >>> Component: cell Component: intracellular Component: cytoplasm",Amino acid transport and metabolism,"PF00571:CBS PF00291:PALP",HGNC:1550,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1JBQ,CBS,CBS,BC011381,Chromosome:21,21q22.3 140,Glycine N-methyltransferase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,Q14749,Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine,"",">Glycine N-methyltransferase MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGV DSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLDKDVPQSAEGGFDAVICLG NSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLTKDVTTSVL IVNNKAHMVTLDYTVQVPGAGQDGSPGLSKFRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQ TYIPCYFIHVLKRTD",GNMT,"",295,32743,7.03,"","Secondary metabolites biosynthesis, transport and catabolism",PF08242:Methyltransf_12,HGNC:4415,Cytoplasm,,"","",None,None,Non Essential,1R74,GNMT,GNMT,X62250,"","" 141,Ig kappa chain V-III region WOL,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P01623,"","",">Ig kappa chain V-III region WOL EIVLTQSPGTLSLSPGERATLSCRASQSVSSGYLGWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGT DFTLTISRLEPEDFAVYYCQQYGSLGRTFGQGTKVEIKR","","",109,11746,9.12,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 142,Tumor necrosis factor,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P01375,"Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation","",">Tumor necrosis factor MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLI SPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLF KGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSA EINRPDYLDFAESGQVYFGIIAL",TNF,"TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin; Contains: RecName: Tumor necrosis factor, membrane form; Contains: RecName: Tumor necrosis factor, soluble form",233,25645,6.92,">>> Function: signal transducer activity Function: receptor binding Function: cytokine activity Function: tumor necrosis factor receptor binding || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response || >>> Component: cell Component: membrane","",PF00229:TNF,HGNC:11892,"Tumor necrosis factor, soluble form:Secreted",,REACT_578-Apoptosis;,"",None,36-56,Non Essential,1A8M,TNF,TNF,AF098751,"","" 143,Protein kinase C delta type,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q05655,"This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin","",">Protein kinase C delta type MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQ IVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFP TMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTG TAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC GINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFI FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIA DFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESI RVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDY SNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED",PRKCD,nPKC-delta,676,77506,7.81,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9399,Cytoplasm (By similarity). Membrane,,"","",None,None,Non Essential,"",PRKCD,PRKCD,D10495,"","" 144,Thyroid peroxidase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P07202,Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4),"",">Thyroid peroxidase MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSP AQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPP KCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTR HVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARP AAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLL RVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAF RFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEEL TERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPD NIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTG LTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRH GYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQAVGTSPQRAA AQDSEQESAGMEGRDTHRLPRAL",TPO,TPO,933,102964,6.75,">>> Function: antioxidant activity Function: peroxidase activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","","PF03098:An_peroxidase PF07645:EGF_CA PF00084:Sushi",HGNC:12015,Membrane,,"","",1-14,847-871,Non Essential,"",TPO,TPO,M55702,"","" 145,Tubulin alpha-1C chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q9BQE3,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-1C chain MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDL EPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHS FGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGADSADGEDEGEEY",TUBA1C,Tubulin alpha-6 chain; Alpha-tubulin 6,449,49896,4.73,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20768,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA1C,TUBA1C,BC063036,Chromosome:12,12q12-q14 146,"Cytochrome c oxidase subunit 6A1, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P12074,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 6A1, mitochondrial MAVVGVSSVSRLLGRSRPQLGRPMSSGAHGEEGSARMWKTLTFFVALPGVAVSMLNVYLKSHHGEHERPE FIAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE",COX6A1,Cytochrome c oxidase polypeptide VIa-liver,109,12155,9.70,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: envelope Component: organelle envelope Component: mitochondrial envelope","",PF02046:COX6A,HGNC:2277,Mitochondrion inner membrane,"","","",None,None,Non Essential,"",COX6A1,COX6A1,X15341,Chromosome:12,12q24.2|12q24.2 147,Tubulin alpha-3C/D chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q13748,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-3C/D chain MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDL EPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHS FGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDLAALEKDYEEVGVDSVEAEAEEGEEY",TUBA3C,Alpha-tubulin 3C/D; Tubulin alpha-2 chain; Alpha-tubulin 2,450,49960,4.74,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12408,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA3C,TUBA3C,L11645,Chromosome:13,13q11 148,Glutathione peroxidase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P07203,Protects the hemoglobin in erythrocytes from oxidative breakdown,"",">Glutathione peroxidase 1 MCAARLAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNELQRRLGPRGLV VLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATA LMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA",GPX1,GSHPx-1; GPx-1; Cellular glutathione peroxidase,201,21946,6.51,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4553,Cytoplasm,,"","",None,None,Non Essential,"",GPX1,GPX1,BC000742,"","" 149,Histone deacetylase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q13547,"Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes","",">Histone deacetylase 1 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSD DYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLH HAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGD LRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKG HAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNM TNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA",HDAC1,HD1,482,55104,5.16,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Function: histone deacetylase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid deacetylation Process: histone deacetylation || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus",Chromatin structure and dynamics,PF00850:Hist_deacetyl,HGNC:4852,Nucleus,,"","",None,None,Non Essential,"",HDAC1,HDAC1,BC000301,"","" 150,Copper-transporting ATPase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q04656,"May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells","",">Copper-transporting ATPase 1 MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMG FDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIK ELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQE ATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTAT FIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSE VESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVE YDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKC YIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENAD EGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEAS LVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMTYMMVMDHHFATLHHNQNMSKEEMINLHSSMF LERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMY ERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVE LVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGAD TTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISR TETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTIT HGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGIS CKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQHKVLIGNREWMIR NGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKT ARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAAD VVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSV VLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSD KRSLNSVVTSEPDKHSLLVGDFREDDDTAL",ATP7A,Copper pump 1; Menkes disease-associated protein,1500,163337,6.31,">>> Function: mercury ion transporter activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: cation binding Function: transition metal ion binding Function: copper ion binding Function: metal ion transporter activity Function: ion binding Function: metal ion binding Function: di-, tri-valent inorganic cation transporter activity Function: copper ion transporter activity Function: copper-exporting ATPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: mercury ion transport Process: metabolism Process: di-, tri-valent inorganic cation transport Process: transition metal ion transport Process: copper ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: metal ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Inorganic ion transport and metabolism,"PF00122:E1-E2_ATPase PF00403:HMA PF00702:Hydrolase",HGNC:869,Isoform 5:Endoplasmic reticulum,,"","",None,"654-675 715-734 742-762 782-802 937-959 990-1011 1357-1374 1386-1405",Non Essential,1Q8L,ATP7A,ATP7A,AY011418,"","" 151,"Actin, cytoplasmic 2",2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P63261,Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells,"",">Actin, cytoplasmic 2 MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYP IEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVL SLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVR DIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFN SIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLS TFQQMWISKQEYDESGPSIVHRKCF",ACTG1,Gamma-actin,375,41793,5.16,">>> Function: binding Function: protein binding Function: structural molecule activity Function: structural constituent of cytoskeleton Function: motor activity || >>> Process: Not Available || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: actin cytoskeleton Component: actin filament",Cytoskeleton,PF00022:Actin,HGNC:144,"Cytoplasm, cytoskeleton",,"","",None,None,Non Essential,1HLU,ACTG1,ACTG1,M16247,Chromosome:17,17q25 152,Cytochrome P450 2B6,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P20813,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics","",">Cytochrome P450 2B6 MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHL GPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKR SVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLIS SVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAH SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTE AVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP R",CYP2B6,CYPIIB6; P450 IIB1,491,56279,8.44,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2615,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP2B6,CYP2B6,AC023172,Chromosome:19,19q13.2 153,Gamma-aminobutyric-acid receptor subunit alpha-3,2009-04-08 04:35:12 UTC,2009-07-22 22:35:21 UTC,P34903,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-3 MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRI LDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNN LLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFG SYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVI QTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVF SALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGA APSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIR KQ",GABRA3,GABA(A) receptor subunit alpha-3,492,55165,8.93,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4077,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-28,"277-298 304-325 338-359 458-479",Non Essential,"",GABRA3,GABRA3,BC028629,"","" 154,Calcium-transporting ATPase type 2C member 2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,O75185,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity),"",">Calcium-transporting ATPase type 2C member 2 MLHFHLLKFKTRVIFSAVIIMVTGLCLFLLSLPHLHGVFEQVPAPWWTSLCPWPIMEAAAFQSGSLYPVA SFLAAPMSELVPDLSFQVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSAL VSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVS LSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIG TGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVA AIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAE VSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDI KNSYIRKKEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQE EKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRN IGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALK SADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVF NLPSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFI FWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIP PLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV",ATP2C2,ATPase 2C2,963,105038,5.79,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: hydrogen transport Process: proton transport Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:29103,Membrane,,"","",None,"119-139 152-170 309-328 341-358 747-766 777-797 818-840 857-876 890-908 924-944",Non Essential,"",ATP2C2,ATP2C2,"",Chromosome:16,16q24.1 155,G1/S-specific cyclin-D1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P24385,Essential for the control of the cell cycle at the G1/S (start) transition,"",">G1/S-specific cyclin-D1 MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEE QKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQM ELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVA AVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEE VDLACTPTDVRDVDI",CCND1,PRAD1 oncogene; BCL-1 oncogene,295,33729,4.68,">>> Function: Not Available || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of cellular physiological process Process: regulation of cell cycle Process: regulation of progression through cell cycle || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF02984:Cyclin_C PF00134:Cyclin_N",HGNC:1582,"",,"","",None,None,Non Essential,"",CCND1,CCND1,L09054,Chromosome:11,11q13 156,Arsenite methyltransferase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q9HBK9,"Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity)","",">Arsenite methyltransferase MAALRDAEIQKDVQTYYGQVLKRSADLQTNGCVTTARPVPKHIREALQNVHEEVALRYYGCGLVIPEHLE NCWILDLGSGSGRDCYVLSQLVGEKGHVTGIDMTKGQVEVAEKYLDYHMEKYGFQASNVTFIHGYIEKLG EAGIKNESHDIVVSNCVINLVPDKQQVLQEAYRVLKHGGELYFSDVYTSLELPEEIRTHKVLWGECLGGA LYWKELAVLAQKIGFCPPRLVTANLITIQNKELERVIGDCRFVSATFRLFKHSKTGPTKRCQVIYNGGIT GHEKELMFDANFTFKEGEIVEVDEETAAILKNSRFAQDFLIRPIGEKLPTSGGCSALELKDIITDPFKLA EESDSMKSRCVPDAAGGCCGTKKSC",AS3MT,S-adenosyl-L-methionine:arsenic(III) methyltransferase; Methylarsonite methyltransferase,375,41748,6.14,"","Secondary metabolites biosynthesis, transport and catabolism",PF08241:Methyltransf_11,HGNC:17452,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",AS3MT,AS3MT,CH471066,Chromosome:10,10q24.32 157,Cyclic AMP-dependent transcription factor ATF-1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P18846,"This protein binds the cAMP response element (CRE) (consensus:5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes","",">Cyclic AMP-dependent transcription factor ATF-1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKD LSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSG STQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTD DPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV",ATF1,Activating transcription factor 1; TREB36 protein,271,29233,8.64,">>> Function: transcription factor activity Function: protein binding Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00170:bZIP_1 PF02173:pKID",HGNC:783,Nucleus,,"","",None,None,Non Essential,"",ATF1,ATF1,BC029619,Chromosome:12,12q13 158,Glutamate [NMDA] receptor subunit epsilon-3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q14957,NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine,"",">Glutamate [NMDA] receptor subunit epsilon-3 MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGVN TTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSAFL QLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRA RTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTES WRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPG GYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGV WNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMF VMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVL VWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMH THMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWK RAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVS SSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGR PPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASERPLSPARCHYSSFPRADRSGRPFLPLFPEPP ELEDLPLLGPEQLARREALLHAAWARGSRPRHASLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRL AQAQSMCLPIYREACQEGEQAGAPAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGH RGRTLGLGTGYRDSGGLDEISRVARGTQGFPGPCTWRRISSLESEV",GRIN2C,N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C,1236,134534,8.50,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","Cell cycle control, cell division, chromosome partitioning","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4587,Cell membrane,,"","",1-19,"554-574 627-647 815-835",Non Essential,"",GRIN2C,GRIN2C,BC140801,Chromosome:17,17q25 159,Cellular tumor antigen p53,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P04637,"Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression","",">Cellular tumor antigen p53 MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAA PRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKT CPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRN TFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGR DRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALEL KDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD",TP53,Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13,393,43713,6.93,">>> Function: transcription factor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00870:P53 PF08563:P53_TAD PF07710:P53_tetramer",HGNC:11998,Cytoplasm. Nucleus. Endoplasmic reticulum,,"","",None,None,Non Essential,1TSR,TP53,TP53,AY270155,Chromosome:17,17p13.1 160,Transcription factor EC,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,O14948,Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form,"",">Transcription factor EC MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVIEDIIG MESSFKEEGADSPLLMQRTLSGSILDVYSGEQGISPINMGLTSASCPSSLPMKREITETDTRALAKERQK KDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLE QANRRLLLRIQELEIQARTHGLPTLASLGTVDLGAHVTKQQSHPEQNSVDYCQQLTVSQGPSPELCDQAI AFSDPLSYFTDLSFSAALKEEQRLDGMLLDDTISPFGTDPLLSATSPAVSKESSRRSSFSSDDGDEL",TFEC,Protein TFE-C; Transcription factor EC-like; hTFEC-L,347,38788,5.16,">>> Function: transcription regulator activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","",PF00010:HLH,HGNC:11754,Nucleus,,"","",None,None,Non Essential,"",TFEC,TFEC,AJ608795,"","" 161,Potassium voltage-gated channel subfamily H member 2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,Q12809,"Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1","",">Potassium voltage-gated channel subfamily H member 2 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLH GPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGS PAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESL ALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVR RASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLA SPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIA VHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALI AHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNV SPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEY FQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLV HAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLE VLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGP GRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKS SDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLN RLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEEL PPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS",KCNH2,Voltage-gated potassium channel subunit Kv11.1; Ether-a-go-go-related gene potassium channel 1; H-ERG; Erg1; Ether-a-go-go-related protein 1; Eag-related protein 1; eag homolog,1159,126656,7.97,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF00989:PAS",HGNC:6251,Membrane,,"","",None,"404-424 451-471 496-516 521-541 548-568 639-659",Non Essential,1BYW,KCNH2,KCNH2,BC004311,"","" 162,"Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3",2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P42771,Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein,"",">Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEP NCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGS NHARIDAAEGPSDIPD",CDKN2A,Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; Multiple tumor suppressor 1; MTS-1,156,16533,5.60,"","",PF00023:Ank,HGNC:1787,"",,"","",None,None,Non Essential,1DC2,CDKN2A,CDKN2A,S69804,"","" 163,Sodium/potassium-transporting ATPase subunit beta-2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P14415,"This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known","",">Sodium/potassium-transporting ATPase subunit beta-2 MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSDHT PKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDN GVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAEN LGNFVMFPANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGR VAFKLRINKT",ATP1B2,Sodium/potassium-dependent ATPase subunit beta-2,290,33367,8.44,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: sodium:potassium-exchanging ATPase activity || >>> Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF00287:Na_K-ATPase,HGNC:805,Membrane,,"","",None,40-67,Non Essential,"",ATP1B2,ATP1B2,BC126175,Chromosome:17,17p13.1 164,Ig heavy chain V-III region POM,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P01774,"","",">Ig heavy chain V-III region POM EVQLLESGGGLVQPGGSLRLSCAASGFTFSSSAMSWVRQAPGKGLEWVAWKYENGNDKHYADSVNGRFTI SRNDSKNTLYLLMNSLQAZBTALYYCARDAGPYVSPTFFAHYGQGTLVT","","",119,12953,8.19,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 165,GTPase KRas,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P01116,Ras proteins bind GDP/GTP and possess intrinsic GTPase activity,"",">GTPase KRas MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQ YMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIP FIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM",KRAS,K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras,189,21656,6.76,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding || >>> Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade Process: small GTPase mediated signal transduction || >>> Component: Not Available","",PF00071:Ras,HGNC:6407,Cell membrane,,"","",None,None,Non Essential,"",KRAS,KRAS,K03210,Chromosome:12,12p12.1 166,Mitogen-activated protein kinase 4,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P31152,Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle,"",">Mitogen-activated protein kinase 4 MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIR RLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYI HSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAI DMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPE VNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNW DTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAF EADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLF LEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNK LGDLNGACIPEHPGDLVQTEAFSKERW",MAPK4,Extracellular signal-regulated kinase 4; ERK-4; MAP kinase isoform p63; p63-MAPK,587,65922,5.11,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6878,"",,"","",None,None,Non Essential,"",MAPK4,MAPK4,X59727,Chromosome:18,18q12-q21 167,Hemoglobin subunit zeta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P02008,"The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac","",">Hemoglobin subunit zeta MSLTKTERTIIVSMWAKISTQADTIGTETLERLFLSHPQTKTYFPHFDLHPGSAQLRAHGSKVVAAVGDA VKSIDDIGGALSKLSELHAYILRVDPVNFKLLSHCLLVTLAARFPADFTAEAHAAWDKFLSVVSSVLTEK YR",HBZ,Hemoglobin zeta chain; Zeta-globin; HBAZ,142,15637,8.51,">>> Function: oxygen binding Function: binding || >>> Process: gas transport Process: oxygen transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4835,"",,"","",None,None,Non Essential,1JEB,HBZ,HBZ,BC027892,Chromosome:16,16p13.3 168,Protein kinase C theta type,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,Q04759,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters","",">Protein kinase C theta type MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVM QIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFF ALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCT GSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANL CGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPL DEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIIL GLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSV DWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQ HPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPG MERLIS",PRKCQ,nPKC-theta,706,81866,7.64,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9410,"",,"","",None,None,Non Essential,1XJD,PRKCQ,PRKCQ,BC113359,Chromosome:10,10p15 169,Tyrosine aminotransferase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P17735,L-tyrosine + 2-oxoglutarate = 4- hydroxyphenylpyruvate + L-glutamate,"",">Tyrosine aminotransferase MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPN KTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVIL TSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTA CLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAK RWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNA DLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVI TVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK",TAT,TAT; L-tyrosine:2-oxoglutarate aminotransferase,454,50400,6.24,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: transaminase activity Function: tyrosine transaminase activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: lyase activity Function: carbon-sulfur lyase activity Function: 1-aminocyclopropane-1-carboxylate synthase activity || >>> Process: aromatic amino acid family metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: amino acid catabolism Process: aromatic amino acid family catabolism Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,"PF00155:Aminotran_1_2 PF07706:TAT_ubiq",HGNC:11573,"",,"","",None,None,Non Essential,"",TAT,TAT,X55675,Chromosome:16,16q22.1 170,Cytochrome c oxidase subunit 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P00395,Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B,"",">Cytochrome c oxidase subunit 1 MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMV MPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPG ASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLL TDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSI GFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTV GGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIG VNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSM NLEWLYGCPPPYHTFEEPVYMKS",MT-CO1,Cytochrome c oxidase polypeptide I,513,57042,6.70,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane",Energy production and conversion,PF00115:COX1,HGNC:7419,Mitochondrion inner membrane,,"","",None,"20-42 57-79 100-122 147-169 182-204 236-258 271-293 303-325 337-359 374-396 409-431 451-473",Non Essential,1OCZ,MT-CO1,MT-CO1,M10546,"Chromosome:MT   
HGNC chromosome: mitochondria","" 171,"Thioredoxin reductase 1, cytoplasmic",2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,Q16881,"Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid","",">Thioredoxin reductase 1, cytoplasmic MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVI FSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAY QEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCV NVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENA YGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASY VALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKV ELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLE WTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFT TLSVTKRSGASILQAGCUG",TXNRD1,TR; Thioredoxin reductase TR1; KM-102-derived reductase-like factor; Gene associated with retinoid-IFN-induced mortality 12 protein; GRIM-12,649,70907,7.42,">>> Function: oxidoreductase activity, acting on NADH or NADPH Function: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor Function: disulfide oxidoreductase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: catalytic activity Function: oxidoreductase activity Function: transporter activity Function: electron transporter activity || >>> Process: homeostasis Process: cell homeostasis Process: cell redox homeostasis Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: intracellular Component: cytoplasm",Energy production and conversion,"PF00462:Glutaredoxin PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim",HGNC:12437,Isoform 5:Cytoplasm,,"","",None,None,Non Essential,1H6V,TXNRD1,TXNRD1,BC018122,Chromosome:12,12q23-q24.1 172,Carbonic anhydrase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P00915,Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVN FEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKAD GLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTW IICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF",CA1,Carbonic anhydrase I; CA-I; Carbonate dehydratase I; Carbonic anhydrase B; CAB,261,28870,7.14,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1368,Cytoplasm,,"","",None,None,Non Essential,1CZM,CA1,CA1,BC027890,"","" 173,Proto-oncogene tyrosine-protein kinase LCK,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P06239,"Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR","",">Proto-oncogene tyrosine-protein kinase LCK MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALH SYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQ LLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYT NASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM SPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYL RSVLEDFFTATEGQYQPQP",LCK,Lymphocyte cell-specific protein-tyrosine kinase; p56-LCK; LSK; T cell-specific protein-tyrosine kinase,509,58001,5.03,">>> Function: protein-tyrosine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","","PF07714:Pkinase_Tyr PF00017:SH2 PF00018:SH3_1",HGNC:6524,Cytoplasm. Cell membrane,,"","",None,None,Non Essential,"",LCK,LCK,X04476,"","" 174,"Alkaline phosphatase, placental-like",2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P10696,A phosphate monoester + H(2)O = an alcohol + phosphate,"",">Alkaline phosphatase, placental-like MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTA ARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQC NTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLI SNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPS VTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTET IMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPY TACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP",ALPPL2,Alkaline phosphatase Nagao isozyme; Germ cell alkaline phosphatase; GCAP; PLAP-like; ALP-1,532,57378,6.31,">>> Function: Not Available || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00245:Alk_phosphatase,HGNC:441,Cell membrane,,"","",1-19,None,Non Essential,1EW2,ALPPL2,ALPPL2,X07247,"","" 175,DNA topoisomerase 2-alpha,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P11388,Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks,"",">DNA topoisomerase 2-alpha MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGI NYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPAL IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFN GEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLD ETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVA VKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKI LNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHN WPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFAD MKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFIN KELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIIN LAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVIS GEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEA ERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNN QARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTD SGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQ VGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDL DSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFP DETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPST SDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF",TOP2A,"DNA topoisomerase II, alpha isozyme",1531,174387,9.17,">>> Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: DNA topoisomerase activity Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: nucleic acid binding Function: DNA binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: DNA topological change Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism || >>> Component: Not Available","Replication, recombination and repair","PF00204:DNA_gyraseB PF00521:DNA_topoisoIV PF08070:DTHCT PF02518:HATPase_c",HGNC:11989,"Cytoplasm. Nucleus, nucleoplasm",,"","",None,None,Non Essential,"",TOP2A,TOP2A,AF064590,Chromosome:17,17q21-q22 176,"Cytochrome c oxidase subunit 8C, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,Q7Z4L0,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 8C, mitochondrial MPLLRGRCPARRHYRRLALLGLQPAPRFAHSGPPRQRPLSAAEMAVGLVVFFTTFLTPAAYVLGNLKQFR RN",COX8C,Cytochrome c oxidase polypeptide 8 isoform 3; Cytochrome c oxidase polypeptide VIII isoform 3; Cytochrome c oxidase subunit 8-3; COX VIII-3,72,8129,12.58,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02285:COX8,HGNC:24382,Mitochondrion inner membrane,"","","",None,41-64,Non Essential,"",COX8C,COX8C,BC101126,Chromosome:14,14q32.13 177,Aquaporin-8,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,O94778,Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea,"",">Aquaporin-8 MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIGCLSVIENGTDTGLLQPAL AHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNA SGAAFVTVQEQGQVAGALVAEIILTTLLALAVCMGAINEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMN PARAFGPAVVANHWNFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR",AQP8,AQP-8,261,27382,6.90,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:642,Membrane,,"","",None,"37-57 85-105 108-128 157-177 184-204 229-249",Non Essential,"",AQP8,AQP8,BC040630,Chromosome:16,16p12 178,Protein kinase C alpha type,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P17252,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters","",">Protein kinase C alpha type MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVC CFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVH KQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQ KTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQ EEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSF GKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMM DGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKS LSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFF TRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV",PRKCA,PKC-alpha; PKC-A,672,76765,7.05,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9393,"",,REACT_604-Hemostasis;,"",None,None,Non Essential,"",PRKCA,PRKCA,AF395829,Chromosome:17,17q22-q23.2 179,Glutathione peroxidase 3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P22352,"Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione","",">Glutathione peroxidase 3 MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVA SYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDV NGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMD ILSYMRRQAALGVKRK",GPX3,GSHPx-3; GPx-3; Extracellular glutathione peroxidase; Plasma glutathione peroxidase; GSHPx-P; GPx-P,226,25553,8.29,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4555,Secreted,,"","",1-20,None,Non Essential,"",GPX3,GPX3,BC050378,"","" 180,Tubulin gamma-2 chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,Q9NRH3,"Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly","",">Tubulin gamma-2 chain MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLE PRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHS IAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPYQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTAL NRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQ SVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIP WGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFESSCQQFDKLRKRDAFLEQFRKEDMFKDNFDE MDRSREVVQELIDEYHAATQPDYISWGTQEQ",TUBG2,Gamma-2-tubulin,451,51092,5.59,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12419,Cytoplasmic,,"","",None,None,Non Essential,"",TUBG2,TUBG2,BC108739,Chromosome:17,17q21 181,Ig heavy chain V-I region SIE,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P01761,"","",">Ig heavy chain V-I region SIE QVQLVQSGAEVKKPGSSVRVTCKTSGGTFSGYTISWVRQAPGRGLEWVGSPAKWTDPFQGVYIKWERVTV SLKPSFNQAYMELVNLFNEDGAVYYCAREWKGQVNVNPFDYWGQGVLVTVSSGS","","",124,13733,9.08,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 182,Sodium/potassium-transporting ATPase subunit beta-3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P54709,"This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known","",">Sodium/potassium-transporting ATPase subunit beta-3 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWVMLQTLNDEVP KYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLEEQKNLTVCPDGALFEQKGPV YVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIGLKPEGVPRIDCVSKNEDIPNVAVYPHNGMI DLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA",ATP1B3,Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3; CD298 antigen,279,31513,8.52,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: sodium:potassium-exchanging ATPase activity || >>> Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF00287:Na_K-ATPase,HGNC:806,Membrane,,"","",None,36-56,Non Essential,"",ATP1B3,ATP1B3,BC011835,"","" 183,Glutamate [NMDA] receptor subunit epsilon-2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,Q13224,NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine,"",">Glutamate [NMDA] receptor subunit epsilon-2 MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVEL VAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDES SMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLD DGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISV SYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLS FSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKI NGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWV MMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKI MVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYA EMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDS GWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMAN LSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNV YQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYS GHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHK RYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVV SGVPAPWEKNLTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRF MDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHG SKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPARFQKDICIGNQSNPCVPNNKNPRAFNGSSN GHVYEKLSSIESDV",GRIN2B,N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; hNR3; NR3,1484,166369,6.92,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00060:Lig_chan,HGNC:4586,Cell membrane,,"","",1-26,"558-578 635-655 818-838",Non Essential,"",GRIN2B,GRIN2B,U28862,Chromosome:12,12p12 184,Cytochrome P450 19A1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P11511,Catalyzes the formation of aromatic C18 estrogens from C19 androgens,"",">Cytochrome P450 19A1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGI GSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPEL WKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDE SAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFAT ELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDI QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEM IFTPRNSDRCLEH",CYP19A1,CYPXIX; Aromatase; Estrogen synthetase; P-450AROM,503,57884,7.56,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2594,Membrane,,"","",None,None,Non Essential,"",CYP19A1,CYP19A1,M28420,Chromosome:15,15q21.1 185,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,O14983,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction,"",">Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRILLLAAC ISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRI KARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNMLFS GTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFN DPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALC NDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRD RKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLR CLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKG TAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAM TGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVG EVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAI GGYVGAATVGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIEMC NALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWLMVLKISLPVIGL DEILKFVARNYLEDPEDERRK",ATP2A1,"SERCA1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; SR Ca(2+)-ATPase 1; Endoplasmic reticulum class 1/2 Ca(2+) ATPase",1001,110254,4.80,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: hydrogen transport Process: proton transport Process: metabolism Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:811,Endoplasmic reticulum membrane,,"","",None,"49-69 90-110 254-273 296-313 758-777 788-808 829-851 898-917 931-949 965-985",Non Essential,1XP5,ATP2A1,ATP2A1,U96781,Chromosome:16,16p12.1 186,Calcium-transporting ATPase type 2C member 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P98194,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium,"",">Calcium-transporting ATPase type 2C member 1 MKVARFQKIPNGENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEP LWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECH CVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDL ASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGII MLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSD KTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNT LMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYC TTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLI ASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIK SLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK NFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSI LTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCS NRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVERSREKIQKHVS STSSSFLEV",ATP2C1,ATPase 2C1; ATP-dependent Ca(2+) pump PMR1,919,100579,6.72,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:13211,Golgi apparatus membrane,,"","",None,"71-91 105-123 263-282 295-312 700-719 730-750 771-793 809-828 842-860 876-896",Non Essential,"",ATP2C1,ATP2C1,AJ010953,"","" 187,Acyl-CoA-binding protein,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P07108,Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor,"",">Acyl-CoA-binding protein MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDA MKAYINKVEELKKKYGI",DBI,ACBP; Diazepam-binding inhibitor; DBI; Endozepine; EP,87,10044,6.54,">>> Function: binding Function: lipid binding Function: fatty acid binding Function: acyl-CoA binding || >>> Process: Not Available || >>> Component: Not Available","",PF00887:ACBP,HGNC:2690,"",,"","",None,None,Non Essential,1NVL,DBI,DBI,BC062996,"","" 188,Ubiquitin,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P62988,"Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair","",">Ubiquitin MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV LRLRGG",RPS27A,"",76,8565,7.54,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification || >>> Component: Not Available","",PF00240:ubiquitin,HGNC:10417,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1V81,RPS27A,RPS27A,M10939,"","" 189,Gamma-aminobutyric acid receptor subunit delta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,O14764,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit delta MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIGGPPVNVALAL EVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVE NKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQ LAQFTITSYRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARV SLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRP RAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLR PIDADTIDIYARAVFPAAFAAVNVIYWAAYAM",GABRD,GABA(A) receptor subunit delta,452,50709,8.73,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4084,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-16,"249-271 275-297 309-331 430-452",Non Essential,"",GABRD,GABRD,BC033801,"","" 190,Hemoglobin subunit theta-1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P09105,"","",">Hemoglobin subunit theta-1 MALSAEDRALVRALWKKLGSNVGVYTTEALERTFLAFPATKTYFSHLDLSPGSSQVRAHGQKVADALSLA VERLDDLPHALSALSHLHACQLRVDPASFQLLGHCLLVTLARHYPGDFSPALQASLDKFLSHVISALVSE YR",HBQ1,Hemoglobin theta-1 chain; Theta-1-globin,142,15508,7.74,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4833,"",,"","",None,None,Non Essential,"",HBQ1,HBQ1,M91453,Chromosome:16,16p13.3 191,Sodium/potassium-transporting ATPase gamma chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P54710,May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase,"",">Sodium/potassium-transporting ATPase gamma chain MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP",FXYD2,Sodium pump gamma chain; Na(+)/K(+) ATPase subunit gamma; FXYD domain-containing ion transport regulator 2,66,7283,8.47,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF02038:ATP1G1_PLM_MAT8,HGNC:4026,Membrane,,"","",None,29-46,Non Essential,"",FXYD2,FXYD2,BC005302,Chromosome:11,11q23 192,"Cytochrome c oxidase subunit 7B, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P24311,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 7B, mitochondrial MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCIVTWTYVATQVGIEWNLSPVG RVTPKEWRNQ",COX7B,Cytochrome c oxidase polypeptide VIIb,80,9161,10.87,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane Component: organelle membrane Component: organelle inner membrane Component: mitochondrial inner membrane Component: mitochondrial electron transport chain","",PF05392:COX7B,HGNC:2291,Mitochondrion inner membrane (By similarity),"","","",None,33-59,Non Essential,"",COX7B,COX7B,BC018386,"","" 193,Gamma-aminobutyric-acid receptor subunit beta-3,2009-04-08 04:35:12 UTC,2009-07-22 22:35:21 UTC,P28472,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit beta-3 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIA SIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQ FSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAK NDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN",GABRB3,GABA(A) receptor subunit beta-3,473,54116,9.41,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4083,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-25,"246-267 271-293 305-327 451-472",Non Essential,"",GABRB3,GABRB3,L04311,Chromosome:15,15q11.2-q12 194,Ig kappa chain V-I region Lay,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P01605,"","",">Ig kappa chain V-I region Lay DIQMTQSPSSLSVSVGDRVTITCQASQNVNAYLNWYQQKPGLAPKLLIYGASTREAGVPSRFSGSGSGTD FTFTISSLQPEDIATYYCQQYNNWPPTFGQGTKVEVKR","","",108,11834,8.18,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 195,Caspase-1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P29466,"Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis","",">Caspase-1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQ ICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEE AQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASD MTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI GRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH",CASP1,CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; IL-1 beta-converting enzyme; ICE; p45; Contains: RecName: Caspase-1 subunit p20; Contains: RecName: Caspase-1 subunit p10,404,45159,5.71,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: cysteine-type endopeptidase activity Function: caspase activity Function: binding Function: protein binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis Process: regulation of biological process Process: regulation of physiological process Process: regulation of cellular physiological process Process: regulation of programmed cell death Process: regulation of apoptosis || >>> Component: cell Component: intracellular","","PF00619:CARD PF00656:Peptidase_C14",HGNC:1499,Cytoplasm,,"","",None,None,Non Essential,1IBC,CASP1,CASP1,BC062327,Chromosome:11,11q23 196,Gamma-aminobutyric acid receptor subunit theta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,Q9UN88,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit theta MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQKILDRVLSRY DVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYETTLNLTLDYRMHEKLWV PDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVED IILFWDDNGNAIHMTEELHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTT ITSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYIN YLFYSRGPRRQPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTST SEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIFPTEIRNRVEAHG HGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDKSDCLAIKEQFKCDTNSTWGL NDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYH MY",GABRQ,GABA(A) receptor subunit theta,632,72022,5.76,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:14454,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-21,"269-289 327-347 612-632",Non Essential,"",GABRQ,GABRQ,AF144648,"","" 197,Mitogen-activated protein kinase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P28482,"Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2","",">Mitogen-activated protein kinase 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLR EIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYI HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSID IWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFP NADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEE TARFQPGYRS",MAPK1,Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1,360,41390,6.99,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6871,"",,"","",None,None,Non Essential,4ERK,MAPK1,MAPK1,BC017832,Chromosome:22,22q11.2|22q11.21 198,Mitogen-activated protein kinase 10,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P53779,"Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity (By similarity)","",">Mitogen-activated protein kinase 10 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPI GSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQ DVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV DDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR",MAPK10,Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; MAP kinase p49 3F12,464,52586,6.78,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6872,Cytoplasm,,"","",None,None,Non Essential,1JNK,MAPK10,MAPK10,BC035057,"","" 199,Interleukin-1 beta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P01584,"Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells","",">Interleukin-1 beta MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVA MDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPY ELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKK MEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS",IL1B,IL-1 beta; Catabolin,269,30748,4.45,">>> Function: cytokine activity Function: interleukin-1 receptor binding Function: signal transducer activity Function: receptor binding Function: growth factor activity || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response Process: inflammatory response || >>> Component: extracellular region","","PF00340:IL1 PF02394:IL1_propep",HGNC:5992,Secreted,,"","",None,None,Non Essential,9ILB,IL1B,IL1B,BC008678,"","" 200,"Cytochrome c oxidase subunit 5B, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P10606,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase subunit 5B, mitochondrial MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKGLDPYNVLAPKGA SGTREDPNLVPSISNKRIVGCICEEDNTSVVWFWLHKGEAQRCPRCGAHYKLVPQQLAH",COX5B,Cytochrome c oxidase polypeptide Vb,129,13696,9.00,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: envelope Component: organelle envelope Component: mitochondrial envelope","",PF01215:COX5B,HGNC:2269,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",COX5B,COX5B,U41284,"","" 201,Aryl hydrocarbon receptor,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P35869,Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues,"",">Aryl hydrocarbon receptor MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVL RLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASS TIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPP ENSPLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEI RTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIV FRLLTKNNRWTWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPF PAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAPFENNFFNESM NECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLYSIMKNLGIDFEDIRHMQNEK FFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQQQQSLALNSSCMVQEHLHLEQQQQHHQKQV VVEPQQQLCQKMKHMQVNGMFENWNSNQFVPFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNF ISCNQPVLPQHSKCTELDYPMGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVS MYQCQPEPQHTHVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFP DLTSSGFL",AHR,Ah receptor; AhR,848,96148,6.34,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: transcription regulator activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of transcription, DNA-dependent Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00010:HLH PF00989:PAS PF08447:PAS_3",HGNC:348,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",AHR,AHR,D38044,"","" 202,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,Q93084,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction,"",">Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAAL VSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRI RARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFS GTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFA DPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALC NDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRD RKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLR CLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG TAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAM TGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVG EVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAI GVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMC NALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILL DEALKYLSRNHMHACLYPGLLRTVSQAWSRQPLTTSWTPDHTGRNEPEVSAGNRVESPVCTSD",ATP2A3,SERCA3; Calcium pump 3; SR Ca(2+)-ATPase 3,1043,113979,5.26,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: hydrogen transport Process: proton transport Process: metabolism Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:813,Nucleus membrane,,"","",None,"49-69 90-110 254-273 296-313 758-777 788-808 829-851 898-917 931-949 965-985",Non Essential,"",ATP2A3,ATP2A3,AF458229,Chromosome:17,17p13.3 203,Sodium/potassium-transporting ATPase subunit alpha-4,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,Q13733,"This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients","",">Sodium/potassium-transporting ATPase subunit alpha-4 MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELSTKYSVDLTKG HSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYL SIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKGGDRVPAD LRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIAS LTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTV CLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFT KSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPF NSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGLGERVL GFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITA KAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTS PQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEE GRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKR LPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQ QWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGM DVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY",ATP1A4,Sodium pump subunit alpha-4; Na(+)/K(+) ATPase alpha-4 subunit,1029,114168,6.61,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: monovalent inorganic cation transporter activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: monovalent inorganic cation transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:14073,Membrane,,"","",None,"96-116 140-160 297-316 329-346 779-798 809-829 850-872 925-944 958-976 992-1012",Non Essential,"",ATP1A4,ATP1A4,BC094801,"","" 204,Alcohol dehydrogenase class 4 mu/sigma chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P40394,"Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism","",">Alcohol dehydrogenase class 4 mu/sigma chain MGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEA TGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHF MNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMG CKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALA SCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVL PFKKISEGFELLNSGQSIRTVLTF",ADH7,Alcohol dehydrogenase class IV mu/sigma chain; Retinol dehydrogenase; Gastric alcohol dehydrogenase,374,40006,8.08,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:256,Cytoplasm,,"","",None,None,Non Essential,1D1S,ADH7,ADH7,S77168,"","" 205,Mitogen-activated protein kinase 12,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P53778,Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down- regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation,"",">Mitogen-activated protein kinase 12 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIW SVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLS FKPPRQLGARVSKETPL",MAPK12,Extracellular signal-regulated kinase 6; ERK-6; ERK5; Stress-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; MAP kinase p38 gamma,367,41941,6.33,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6874,Cytoplasm. Mitochondrion,,"","",None,None,Non Essential,1CM8,MAPK12,MAPK12,BC015741,Chromosome:22,22q13.33 206,Delta-aminolevulinic acid dehydratase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P13716,2 5-aminolevulinate = porphobilinogen + 2 H(2)O,"",">Delta-aminolevulinic acid dehydratase MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVE EGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGA FRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRD AAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSG EFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE",ALAD,ALADH; Porphobilinogen synthase,330,36295,6.78,">>> Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: porphobilinogen synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis Process: heme biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00490:ALAD,HGNC:395,"",,"","",None,None,Non Essential,1E51,ALAD,ALAD,AY319481,"","" 207,Superoxide dismutase [Cu-Zn],2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P00441,Destroys radicals which are normally produced within the cells and which are toxic to biological systems,"",">Superoxide dismutase [Cu-Zn] MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR KHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGN AGSRLACGVIGIAQ",SOD1,"",154,15936,6.07,">>> Function: binding Function: ion binding Function: metal ion binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on superoxide radicals as acceptor Function: superoxide dismutase activity Function: copper, zinc superoxide dismutase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: superoxide metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00080:Sod_Cu,HGNC:11179,Cytoplasm,,"","",None,None,Non Essential,1PU0,SOD1,SOD1,X95228,Chromosome:21,21q22.1|21q22.11 208,Estrogen receptor beta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,Q92731,"Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual","",">Estrogen receptor beta MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPG RQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGP GSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCY EVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHV LISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDH PGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDL LLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ",ESR2,ER-beta; Nuclear receptor subfamily 3 group A member 2,530,59217,8.55,">>> Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:3468,Nucleus,,"","",None,None,Non Essential,1QKM,ESR2,ESR2,BC024181,Chromosome:14,14q23.2 209,Protein kinase C iota type,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P41743,"Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. May play a role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. Functions in both pro- and anti-apoptotic pathways. Functions in the RAC1/ERK signaling required for transformed growth. Plays a role in microtubule dynamics through interaction with RAB2 and GAPDH and recruitment to vesicular tubular clusters (VTCs)","",">Protein kinase C iota type MSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCT VSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFN RRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPY NPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKEL VNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYS AEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGED YGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNK DPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDD IVRKIDQSEFEGFEYINPLLMSAEECV",PRKCI,nPKC-iota; Atypical protein kinase C-lambda/iota; aPKC-lambda/iota; PRKC-lambda/iota,587,67259,5.68,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: signal transducer activity Function: receptor activity Function: phorbol ester receptor activity Function: protein kinase C activity Function: atypical protein kinase C activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00564:PB1 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9404,Cytoplasm. Membrane. Endosome. Nucleus,,"","",None,None,Non Essential,"",PRKCI,PRKCI,BC022016,"","" 210,Leptin,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P41159,May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass,"",">Leptin MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPIL TLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGY STEVVALSRLQGSLQDMLWQLDLSPGC",LEP,Obesity factor; Obese protein,167,18641,6.34,">>> Function: signal transducer activity Function: receptor binding Function: hormone activity || >>> Process: cellular process Process: cell communication Process: signal transduction || >>> Component: extracellular region","",PF02024:Leptin,HGNC:6553,Secreted,,"","",1-21,None,Non Essential,1AX8,LEP,LEP,BC069527,"","" 211,NADH-ubiquinone oxidoreductase chain 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P03886,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH-ubiquinone oxidoreductase chain 1 MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEPLKPATSTITL YITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTI SYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSG FNIEYAAGPFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRF RYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT",MT-ND1,NADH dehydrogenase subunit 1,318,35661,6.53,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane",Energy production and conversion,PF00146:NADHdh,HGNC:7455,Mitochondrion inner membrane,,"","",None,"2-22 68-88 100-120 146-166 171-191 231-251 253-273 294-314",Non Essential,"",MT-ND1,MT-ND1,M10546,"Chromosome:MT   
HGNC chromosome: mitochondria","" 212,Calcineurin subunit B type 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P63098,"Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity","",">Calcineurin subunit B type 1 MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEV DFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINA DKDGDGRISFEEFCAVVGGLDIHKKMVVDV",PPP3R1,Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1,170,19300,4.40,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: Not Available || >>> Component: Not Available","",PF00036:efhand,HGNC:9317,"",,REACT_578-Apoptosis;,"",None,None,Non Essential,1MF8,PPP3R1,PPP3R1,BC027913,"","" 213,Steroid hormone receptor ERR1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P11474,"Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter","",">Steroid hormone receptor ERR1 MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLV LSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCL RVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLY AMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPL QDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQ LREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEA MMD",ESRRA,"Estrogen-related receptor, alpha; ERR-alpha; Estrogen receptor-like 1; Nuclear receptor subfamily 3 group B member 1",423,45510,6.33,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:3471,Nucleus,,"","",None,None,Non Essential,1XB7,ESRRA,ESRRA,X51416,Chromosome:11,11q13 214,Aquaporin-10,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,Q96PS8,Forms a water channel. Not permeable to urea and glycerol. May contribute to water transport in the upper portion of small intestine,"",">Aquaporin-10 MVFTQAPAEIMGHLRIRSLLARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFLAGSLAVTIAI YVGGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQLLSAFCASGATYVLYHDALQNYTGGNLTVTGPK ETASIFATYPAPYLSLNNGFLDQVLGTGMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLSMGANCG IPLNPARDLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGTATYQLLVALHHPEGPEPAQDLVS AQHKASELETPASAQMLECKL",AQP10,AQP-10; Small intestine aquaporin,301,31764,6.78,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:16029,Membrane,,"","",None,"28-48 53-73 102-122 157-177 188-208",Non Essential,"",AQP10,AQP10,BC074897,"","" 215,Protamine-2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P04554,"Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex","",">Protamine-2 MVRYRVRSLSERSHEVYRQQLHGQEQGHHGQEEQGLSPEHVEVYERTHGQSHYRRRHCSRRRLHRIHRRQ HRSCRRRKRRSCRHRRRHRRGCRTRKRTCRRH",PRM2,Sperm protamine-P2; Sperm histone P2; Contains: RecName: Basic nuclear protein HPI1; Contains: RecName: Basic nuclear protein HPI2; Contains: RecName: Basic nuclear protein HPS1; Contains: RecName: Basic nuclear protein HPS2; Contains: RecName: Sperm histone HP4; Sperm protamine P4; Contains: RecName: Sperm histone HP2; Sperm protamine P2; P2'; Contains: RecName: Sperm histone HP3; Sperm protamine P3; P2'',102,13051,12.39,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: reproduction Process: sexual reproduction Process: gametogenesis Process: male gamete generation Process: spermatogenesis Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00841:Protamine_P2,HGNC:9448,Nucleus,,"","",None,None,Non Essential,"",PRM2,PRM2,BC066338,Chromosome:16,16p13.2 216,Tyrosinase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P14679,"This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone","",">Tyrosinase MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFP FTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTL AKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPW HRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLE EYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASP LTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTA LLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL",TYR,Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB,529,60394,6.05,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","",PF00264:Tyrosinase,HGNC:12442,Melanosome membrane,,"","",1-18,477-497,Non Essential,"",TYR,TYR,AY012019,Chromosome:11,11q14-q21 217,Sodium/potassium-transporting ATPase subunit alpha-2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P50993,"This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients","",">Sodium/potassium-transporting ATPase subunit alpha-2 MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKGLTNQRAQDVL ARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAMEDEPSNDNLYLGVVLAAVVIV TGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCK VDNSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRT PIAMEIEHFIQLITGVAVFLGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMA RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALS RIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPFNSTNKYQLSI HEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYMELGGLGERVLGFCQLNLPSG KFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGI ISEGNETVEDIAARLNIPMSQVNPREAKACVVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVE GCQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLK KSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDK LVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYGQEWTYEQRKV VEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSYCPGMGVALRMYPL KVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY",ATP1A2,Sodium pump subunit alpha-2; Na(+)/K(+) ATPase alpha-2 subunit,1020,112267,5.33,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: monovalent inorganic cation transporter activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: monovalent inorganic cation transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:800,Membrane,,"","",None,"86-106 130-150 287-306 319-336 770-789 800-820 841-863 916-935 949-967 983-1003",Non Essential,1Q3I,ATP1A2,ATP1A2,Y07494,"","" 218,Retinoic acid receptor gamma-1,2009-04-08 04:35:12 UTC,2009-07-22 22:36:36 UTC,P13631,This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression,"",">Retinoic acid receptor gamma MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSS EEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRN RCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKY TTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYT PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKV DKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA",RARG,RAR-gamma; Nuclear receptor subfamily 1 group B member 3,454,50342,7.52,">>> Function: retinoic acid receptor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:9866,Nucleus,,"","",None,None,Non Essential,1EXX,RARG,RARG,AY013704,Chromosome:12,12q13 219,Tubulin beta-2A chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,Q13885,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-2A chain MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEP GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK TAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATADEQGEFEEEEGEDEA",TUBB2A,"",445,49908,4.52,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12412,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB2A,TUBB2A,BC018780,"","" 220,"Cytochrome c oxidase subunit 5A, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P20674,"This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase subunit 5A, mitochondrial MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYFNKPDIDAWEL RKGINTLVTYDMVPEPKIIDAALRACRRLNDFASLVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGIS TPEELGLDKV",COX5A,Cytochrome c oxidase polypeptide Va,150,16774,6.78,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02284:COX5A,HGNC:2267,Mitochondrion inner membrane,,"","",None,None,Non Essential,1V55,COX5A,COX5A,M22760,Chromosome:15,15q24.1 221,"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P13073,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase subunit 4 isoform 1, mitochondrial MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASW SSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGPLPQSFDKEWVAK QTKRMLDMKVNPIQGLASKWDYEKNEWKK",COX4I1,Cytochrome c oxidase subunit IV isoform 1; COX IV-1; Cytochrome c oxidase polypeptide IV,169,19577,10.12,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02936:COX4,HGNC:2265,Mitochondrion inner membrane,,"","",None,None,Non Essential,1V55,COX4I1,COX4I1,BC021236,Chromosome:16,16q22-qter 222,Haptoglobin,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P00738,"Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes","",">Haptoglobin MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLND KKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGD KLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSE NATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGY VSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDT CYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN",HP,Contains: RecName: Haptoglobin alpha chain; Contains: RecName: Haptoglobin beta chain,406,45206,6.56,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity Function: binding Function: protein binding Function: hemoglobin binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis || >>> Component: extracellular region","","PF00084:Sushi PF00089:Trypsin",HGNC:5141,Secreted,,"","",1-18,None,Non Essential,"",HP,HP,X00606,Chromosome:16,16q22.1 223,Tubulin alpha-1B chain,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,P68363,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-1B chain MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDL EPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHS FGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGVDSVEGEGEEEGEEY",TUBA1B,Tubulin alpha-ubiquitous chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1,451,50152,4.70,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:18809,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA1B,TUBA1B,BC071904,Chromosome:12,12q13.12 224,Gamma-aminobutyric-acid receptor subunit beta-1,2009-04-08 04:35:13 UTC,2009-07-22 22:35:21 UTC,P18505,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit beta-1 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVA SIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQ FSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGI TTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANE KNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH",GABRB1,GABA(A) receptor subunit beta-1,474,54235,9.01,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4081,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-25,"246-267 271-293 305-327 452-473",Non Essential,"",GABRB1,GABRB1,S70733,"","" 225,Mitogen-activated protein kinase 7,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q13164,"Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways","",">Mitogen-activated protein kinase 7 MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVS SARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLM ESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTS PAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGT PSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY HDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSR LRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLV LSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQ PACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAP QSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADS ASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP",MAPK7,Extracellular signal-regulated kinase 5; ERK-5; ERK4; Big MAP kinase 1; BMK1 kinase,816,88387,5.68,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6880,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",MAPK7,MAPK7,BC030134,Chromosome:17,17p11.2 226,C-jun-amino-terminal kinase-interacting protein 2,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q13387,"The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins (By similarity)","",">C-jun-amino-terminal kinase-interacting protein 2 MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSLSLGRSEQPHP ICSFQDDFQEFEMIDDNEEEDDEDEEEEEEEEEGDGEGQEGGDPGSEAPAPGPLIPSPSVEEPHKHRPTT LRLTTLGAQDSLNNNGGFDLVRPASWQETALCSPAPEALRELPGPLPATDTGPGGAQSPVRPGCDCEGNR PAEPPAPGGTSPSSDPGIEADLRSRSSGGRGGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSS DGGSSSSGRSSHLTNSIEEASSPASEPEPPREPPRRPAFLPVGPDDTNSEYESGSESEPDLSEDADSPWL LSNLVSRMISEGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVELVDMETLCAPPPP APAAPRPGPAQPGPCLFLSNPTRDTITPLWAAPGRAARPGRACSAACSEEEDEEDDEEEEDAEDSAGSPG GRGTGPSAPRDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDSGGEASEEEAGAALLGGGQVS GDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNGEEREQTHRAVFRFIPRHPDELELDVDDP VLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNG ILCAAMQKIATARKLTVHLRPPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYF GFITKHPLLSRFACHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE",MAPK8IP2,JNK-interacting protein 2; JIP-2; JNK MAP kinase scaffold protein 2; Islet-brain-2; IB-2; Mitogen-activated protein kinase 8-interacting protein 2,824,87975,4.08,"","","PF00640:PID PF00018:SH3_1",HGNC:6883,Cytoplasm,,"","",None,None,Non Essential,"",MAPK8IP2,MAPK8IP2,U79261,Chromosome:22,22q13.33 227,Ribonucleoside-diphosphate reductase subunit M2 B,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q7LG56,Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage,"",">Ribonucleoside-diphosphate reductase subunit M2 B MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQASFWTAEEVD LSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSL LIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKK RGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCI LMKQYIEFVADRLLVELGFSKVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDAD F",RRM2B,TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2,351,40737,4.61,">>> Function: oxidoreductase activity, acting on CH2 groups Function: oxidoreductase activity, acting on CH2 groups, disulfide as acceptor Function: ribonucleoside-diphosphate reductase activity Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleoside diphosphate metabolism Process: deoxyribonucleoside diphosphate metabolism || >>> Component: Not Available",Nucleotide transport and metabolism,PF00268:Ribonuc_red_sm,HGNC:17296,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",RRM2B,RRM2B,BC130628,"","" 228,Tubulin beta-8 chain,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q3ZCM7,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-8 chain MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYVPRAVLVDLEP GTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVVRKEAESCDCLQGFQLTHSLG GGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQLIENADETFCIDNEALYDI CSKTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVAELTQQMFDAKNMMAACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVK TAVCDIPPRGLKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEEEDEEYAEEEVA",TUBB8,"",444,49777,4.52,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C","",Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB8,"",BC101271,"","" 229,"Thioredoxin reductase 2, mitochondrial",2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q9NNW7,Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling,"",">Thioredoxin reductase 2, mitochondrial MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDY VEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLN WGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCA PSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATS VPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHG QEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQV MRTVGIHPTCSEEVVKLRISKRSGLDPTVTGCUG",TXNRD2,Thioredoxin reductase TR3; TR-beta; Selenoprotein Z; SelZ,524,56507,7.55,">>> Function: oxidoreductase activity, acting on NADH or NADPH Function: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor Function: disulfide oxidoreductase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: intracellular Component: cytoplasm",Energy production and conversion,"PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim",HGNC:18155,Mitochondrion,,"","",None,None,Non Essential,"",TXNRD2,TXNRD2,BC007489,Chromosome:22,22q11.21 230,Hypoxia-inducible factor 1 alpha,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q16665,"Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP","",">Hypoxia-inducible factor 1 alpha MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVR KLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCD HEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQC GYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYH ALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDL IFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFT MPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLE MLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTT VPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKT IILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN",HIF1A,HIF-1 alpha; HIF1 alpha; ARNT-interacting protein; Member of PAS protein 1; Basic-helix-loop-helix-PAS protein MOP1,826,92671,4.97,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity Function: transcription regulator activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of transcription, DNA-dependent Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus",Signal transduction mechanisms,"PF08778:HIF-1a_CTAD PF00010:HLH PF08447:PAS_3",HGNC:4910,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",HIF1A,HIF1A,BC012527,Chromosome:14,14q21-q24 231,NF-kappa-B-repressing factor,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,O15226,"Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription","",">NF-kappa-B-repressing factor MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPVHFVASSSKDE RQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGFILTKDQPVTANMYFDSGNPA PSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTATIWKNLSNPEMTSGSDKINYTYMLTRCIQAC KTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEV RVVRRKFKHTFGEDLVVCQIGMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAI GILNNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQPTYPSVK SSQCHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIA EAVGVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLR KMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNKIAKRDIEQIIRNYARSESHTDLTFSRELTN DERKQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN",NKRF,NFkB-repressing factor; Transcription factor NRF; ITBA4 protein,690,77674,9.09,">>> Function: binding Function: nucleic acid binding Function: RNA binding Function: double-stranded RNA binding || >>> Process: Not Available || >>> Component: cell Component: intracellular","","PF00035:dsrm PF01585:G-patch PF01424:R3H",HGNC:19374,"Nucleus, nucleolus",,"","",None,None,Non Essential,"",NKRF,NKRF,Y07707,"","" 232,Mitogen-activated protein kinase 14,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q16539,"Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis","",">Mitogen-activated protein kinase 14 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKY IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVG CIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL AVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVP PPLDQEEMES",MAPK14,Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A,360,41294,5.58,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6876,Cytoplasm (By similarity). Nucleus (By similarity),,"","",None,None,Non Essential,1W84,MAPK14,MAPK14,BC031574,"","" 233,Aquaporin-9,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,O43315,"Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea but not to glycerol","",">Aquaporin-9 MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAM AIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVG ENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLN SGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKAE QSEDKPEKYELSVIM",AQP9,AQP-9; Small solute channel 1,295,31401,7.95,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:643,Membrane,,"","",None,"30-50 55-75 111-131 159-179 190-210 246-266",Non Essential,"",AQP9,AQP9,BC026258,Chromosome:15,15q22.1-q22.2 234,Aquaporin-1,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,P29972,"Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient","",">Aquaporin-1 MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHI SGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLG IEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHW IFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK",AQP1,AQP-1; Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule; Urine water channel,269,28526,7.50,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:633,Membrane,,"","",None,"8-36 49-66 77-84 95-115 137-155 167-183 193-200 208-228",Non Essential,1H6I,AQP1,AQP1,AF480415,"","" 235,Aquaporin-7,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,O14520,Forms a channel for water and glycerol,"",">Aquaporin-7 MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGV NLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILH FSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILV VIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTI PREPLKLEDSVAYEDHGITVLPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF",AQP7,AQP-7; Aquaporin-7-like; Aquaporin adipose; AQPap,342,37232,9.22,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:640,Membrane,,"","",None,"37-57 66-86 114-134 171-191 197-217 256-276",Non Essential,"",AQP7,AQP7,AL356218,"","" 236,Beta-nerve growth factor,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P01138,Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons,"",">Beta-nerve growth factor MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNI TVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVS VWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKA LTMDGKQAAWRFIRIDTACVCVLSRKAVRRA",NGF,Beta-NGF,241,26959,10.54,">>> Function: signal transducer activity Function: receptor binding Function: growth factor activity || >>> Process: Not Available || >>> Component: Not Available","",PF00243:NGF,HGNC:7808,Secreted,,"","",1-18,None,Non Essential,1SG1,NGF,NGF,X52599,"","" 237,Glutamate [NMDA] receptor subunit 3B,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,O60391,"NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine","",">Glutamate [NMDA] receptor subunit 3B MEFVRALWLGLALALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARAALAPRLPHNL SLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLHFLAAATETPVLSLLRREARAPLG APNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPGGLVALWTSRAGRPPQLVLDLSRRDT GDAGLRARLAPMAAPVGGEAPVPAAVLLGCDIARARRVLEAVPPGPHWLLGTPLPPKALPTAGLPPGLLA LGEVARPPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGR TGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVV TLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYCIDLLERLAED TPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRAR DTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRR TVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWES SAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAI EGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCL GLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEPSGPEVEQQQQ QQDQPTAPEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGPVWLCSYGRPPAARPTGAPQP GELQELERRIEVARERLRQALVRRGQLLAQLGDSARHRPRRLLQARAAPAEAPPHSGRPGSQE",GRIN3B,N-methyl-D-aspartate receptor subtype NR3B; NMDAR3B; NR3B,1043,112993,9.50,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00060:Lig_chan,HGNC:16768,Cell membrane,,"","",1-22,"565-585 649-669 831-851",Non Essential,"",GRIN3B,GRIN3B,BK004079,Chromosome:19,19p13.3 238,Thymosin beta-4,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P62328,Seraspenide inhibits the entry of hematopoeitic pluripotent stem cells into the S-phase (By similarity),"",">Thymosin beta-4 MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES",TMSB4X,T beta-4; Fx; Contains: RecName: Hematopoietic system regulatory peptide; Seraspenide,44,5053,4.72,">>> Function: binding Function: protein binding Function: cytoskeletal protein binding Function: actin binding || >>> Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis || >>> Component: cell Component: intracellular Component: cytoplasm","",PF01290:Thymosin,HGNC:11881,"Cytoplasm, cytoskeleton",,"","",None,None,Non Essential,"",TMSB4X,TMSB4X,X02493,"","" 239,Glutathione peroxidase 7,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q96SL4,2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O,"",">Glutathione peroxidase 7 MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQL QRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEP TWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLILLKREDL",GPX7,CL683,187,20996,8.46,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4559,Secreted (Potential),,"","",1-19,None,Non Essential,"",GPX7,GPX7,AF091092,"","" 240,Aquaporin-3,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q92482,"Forms a water-specific channel that provide kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. May function as a water and urea exit mechanism in antidiuresis in collecting duct cells. Also slightly permeable to urea and glycerol. May play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity)","",">Aquaporin-3 MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLG ILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGP NGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNS GYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEEN VKLAHVKHKEQI",AQP3,AQP-3,292,31544,7.25,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:636,Basolateral cell membrane,,"","",None,"29-49 54-74 110-130 158-178 189-209 245-265",Non Essential,"",AQP3,AQP3,BC013566,"","" 241,Parathyroid hormone/parathyroid hormone-related peptide receptor,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q03431,This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system,"",">Parathyroid hormone/parathyroid hormone-related peptide receptor MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWT SASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNH KGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILA YFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAG CRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTG CWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVH YIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSG SSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKD DGFLNGSCSGLDEEASGPERPPALLQEEWETVM",PTHR1,PTH/PTHrP type I receptor; PTH/PTHr receptor,593,66361,8.05,">>> Function: secretin-like receptor activity Function: parathyroid hormone receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF00002:7tm_2 PF02793:HRM",HGNC:9608,Cell membrane,,"","",1-26,"189-212 220-239 283-306 321-342 362-382 410-428 441-463",Non Essential,1BL1,PTHR1,PTH1R,BC112247,"","" 242,Tubulin beta-3 chain,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q13509,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin beta-3 chain MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEP GTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLG GGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDI CFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQ YRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVK VAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEEGEMYEDDEEESEAQGPK",TUBB3,Tubulin beta-III; Tubulin beta-4,450,50433,4.57,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20772,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB3,TUBB3,BC003021,Chromosome:16,16q24.3 243,Thyrotroph embryonic factor,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q10587,Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3',"",">Thyrotroph embryonic factor MSDAGGGKKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMENPPREARLDKEKGKEKLEEDEAAAAS TMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKESASSSTAS PPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAE EDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVA ELRKEVGKCKTIVSKYETKYGPL",TEF,"",303,33248,5.86,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","",PF07716:bZIP_2,HGNC:11722,Nucleus,,"","",None,None,Non Essential,"",TEF,TEF,BX537848,Chromosome:22,22q13|22q13.2 244,Gamma-aminobutyric acid receptor subunit pi,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,O00591,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone","",">Gamma-aminobutyric acid receptor subunit pi MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTLDIA SISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLI RLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQY TIERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVS ITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL LFPLIFMLANVFYWAYYMYF",GABRP,GABA(A) receptor subunit pi,440,50641,6.99,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4089,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-16,"243-266 270-292 305-327 417-438",Non Essential,"",GABRP,GABRP,BC074865,"","" 245,Protein kinase C zeta type,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q05513,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization","",">Protein kinase C zeta type MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDPCTV SSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNR RAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETD GIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAM KVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPE EHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLT PDDEDAIKRIDQSEFEGFEYINPLLLSTEESV",PRKCZ,nPKC-zeta,592,67661,5.52,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: signal transducer activity Function: receptor activity Function: phorbol ester receptor activity Function: protein kinase C activity Function: atypical protein kinase C activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00564:PB1 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9412,Cytoplasm. Endosome,,"","",None,None,Non Essential,"",PRKCZ,PRKCZ,BC014270,"","" 246,Gamma-aminobutyric-acid receptor subunit alpha-4,2009-04-08 04:35:13 UTC,2009-07-22 22:35:22 UTC,P48169,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-4 MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGP VTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKS VSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEK SVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWI NKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEK AKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTV NTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM",GABRA4,GABA(A) receptor subunit alpha-4,554,61624,10.02,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4078,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-35,"259-280 285-306 318-340 524-543",Non Essential,"",GABRA4,GABRA4,U20166,"","" 247,Tubulin beta-2B chain,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q9BVA1,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-2B chain MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEP GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK TAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATADEQGEFEEEEGEDEA",TUBB2B,"",445,49954,4.52,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:30829,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB2B,TUBB2B,BC063610,"","" 248,Estrogen sulfotransferase,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P49888,"May control the level of the estrogen receptor by sulfurylating free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated","",">Estrogen sulfotransferase MNSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCK EDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYY FFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFL ERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYE QQMKESTLKFRTEI",SULT1E1,"Sulfotransferase, estrogen-preferring; EST-1",294,35127,6.61,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring sulfur-containing groups Function: sulfotransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00685:Sulfotransfer_1,HGNC:11377,Cytoplasm,,"","",None,None,Non Essential,1G3M,SULT1E1,SULT1E1,U55764,"","" 249,Catalase,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P04040,"Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells","",">Catalase MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDEMAHFDRERIP ERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTED GNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHR HMNGYGSHTFKLVNANGEAVYCKFHYKTDQGIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFY IQVMTFNQAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKM LQGRLFAYPDTHRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVKNFTEVHPDYG SHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL",CAT,"",527,59757,7.41,">>> Function: antioxidant activity Function: peroxidase activity Function: catalase activity || >>> Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00199:Catalase,HGNC:1516,Peroxisome,,"","",None,None,Non Essential,1F4J,CAT,CAT,K02400,Chromosome:11,11p13 250,Serum albumin,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P02768,"Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood","",">Serum albumin MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEV TEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLV RPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELR DEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADD RADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVF LGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEK TPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHK PKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL",ALB,"",609,69367,6.21,">>> Function: transporter activity Function: carrier activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: extracellular region Component: extracellular space","",PF00273:Serum_albumin,HGNC:399,Secreted,,REACT_604-Hemostasis;,"",1-18,None,Non Essential,1HA2,ALB,ALB,M13075,"","" 252,Histone H3.1,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P68431,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H3.1 MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQR LVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA",HIST1H3A,H3/a; H3/b; H3/c; H3/d; H3/f; H3/h; H3/i; H3/j; H3/k; H3/l,136,15404,11.71,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:4766,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H3A,HIST1H3A,BC127610,"","" 253,Histone H3.2,2009-04-08 04:35:13 UTC,2009-06-30 03:51:50 UTC,Q71DI3,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H3.2 MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQR LVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA",HIST2H3A,H3/m; H3/o,136,15388,11.83,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:20505,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST2H3A,HIST2H3A,BC130637,"","" 254,Glutamate [NMDA] receptor subunit epsilon-1,2009-04-08 04:35:13 UTC,2009-06-30 03:51:50 UTC,Q12879,NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits,"",">Glutamate [NMDA] receptor subunit epsilon-1 MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVV ALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDP TSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSF EDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVS YDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSF TEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVN NVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVM MFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIM VSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSP WKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNM NSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNMNELQTFVANRQKDNLNNYVF QGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPR YLPEEMAHSDISETSNRATCHREPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTI DGEKEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKH FTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLFS VPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDSY LRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNRRVYKKMPSIESDV",GRIN2A,N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A,1464,165284,7.11,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00060:Lig_chan,HGNC:4585,Cell membrane,,"","",1-22,"556-576 634-654 817-837",Non Essential,"",GRIN2A,GRIN2A,U90277,Chromosome:16,16p13.2 255,Sodium/potassium-transporting ATPase subunit alpha-3,2009-04-08 04:35:13 UTC,2009-06-30 03:51:50 UTC,P13637,"This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients","",">Sodium/potassium-transporting ATPase subunit alpha-3 MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNAL TPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQ EAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTG ESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEH FIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKN LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNR AVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPND NRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFA FDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNET VEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGA IVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL TSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLI SMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHT AFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFC AFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY",ATP1A3,Sodium pump subunit alpha-3; Na(+)/K(+) ATPase alpha-3 subunit; Na(+)/K(+) ATPase alpha(III) subunit,1013,111750,5.02,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: monovalent inorganic cation transporter activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: monovalent inorganic cation transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:801,Membrane,,"","",None,"78-98 122-142 279-298 311-328 763-782 793-813 834-856 909-928 942-960 976-996",Non Essential,"",ATP1A3,ATP1A3,M27577,Chromosome:19,19q13.31 256,Ig kappa chain V-III region POM,2009-04-08 04:35:13 UTC,2009-06-30 03:51:50 UTC,P01624,"","",">Ig kappa chain V-III region POM EIVMTQSPVTLSVSPGERATLSCRASQSISNSYLAWYQQKPSGSPRLLIYGASTRATGIPARFSGSGSGT EFTLTISSLQSEDFAVYYCQQYNNWPPTFGQGTRVEIKR","","",109,11922,9.12,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 257,Gamma-aminobutyric-acid receptor subunit alpha-6,2009-04-08 04:35:13 UTC,2009-07-22 22:35:22 UTC,Q16445,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-6 MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPV SDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQ NGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDL IGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTV LTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTIS KATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE",GABRA6,GABA(A) receptor subunit alpha-6,453,51025,8.40,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4080,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-19,"243-264 269-290 301-324 420-441",Non Essential,"",GABRA6,GABRA6,BC099641,"","" 265,Sodium channel subunit beta-2,2009-05-01 20:58:19 UTC,2009-06-30 03:51:41 UTC,O60939,"Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity)","",">Sodium channel subunit beta-2 MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQ ECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHG KIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNP DDGAK",SCN2B,"",215,24326,6.35,">>> Function: Not Available || >>> Process: Not Available || >>> Component: cell Component: membrane","",PF07686:V-set,HGNC:10589,Membrane,,"","",1-29,160-180,Non Essential,"",SCN2B,SCN2B,BC036793,Chromosome:11,11q23 266,Sodium channel subunit beta-3,2009-05-01 20:58:59 UTC,2009-06-30 03:51:40 UTC,Q9NY72,Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity),"",">Sodium channel subunit beta-3 MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGK DFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRL IPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSA VPVEE",SCN3B,"",215,24703,4.35,"","",PF07686:V-set,HGNC:20665,Membrane,,"","",1-22,160-180,Non Essential,"",SCN3B,SCN3B,BC126265,Chromosome:11,11q23.3 267,Sodium channel subunit beta-1,2009-05-01 21:00:32 UTC,2009-06-30 03:51:48 UTC,Q07699,"Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons","",">Sodium channel subunit beta-1 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKI LRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVK KIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKEN CTGVQVAE",SCN1B,"",218,24707,4.56,"","",PF00047:ig,HGNC:10586,Membrane,,"","",1-18,161-182,Non Essential,"",SCN1B,SCN1B,BC067122,Chromosome:19,19q13.1 268,Sodium channel subunit beta-4,2009-05-01 21:00:55 UTC,2009-06-30 03:51:49 UTC,Q8IWT1,"Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity)","",">Sodium channel subunit beta-4 MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTY NSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENN LQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDN TENGLPGSKAEEKPPSKV",SCN4B,"",228,24969,7.45,"","",PF07686:V-set,HGNC:10592,Membrane,,"","",1-30,163-183,Non Essential,"",SCN4B,SCN4B,AY149967,Chromosome:11,11q23.3 269,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,2009-05-04 16:51:55 UTC,2009-06-30 03:51:44 UTC,Q9P1Z3 ,Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (By similarity),"",">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKA VEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLD LVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIV RFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPP DCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALI QSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCR GLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSY FGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSE PSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGP LPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGG GGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQL SANM",HCN3,"",774,86033,10.12,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08412:Ion_trans_N",HGNC:19183,Membrane,,"","",None,"98-118 125-145 172-192 202-222 254-274 298-319 330-350",Non Essential,"",HCN3,HCN3,BC000066,"","" 270,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,2009-05-04 16:55:51 UTC,2009-06-30 03:51:49 UTC,O60741,"Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli","",">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGG GGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSD FRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDP KVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQ WEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALF KAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSF HKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSK LRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCR LYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDR EMVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYT TAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKS TQALHNTNLTREVRPFSAWQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVT LFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL",HCN1,Brain cyclic nucleotide-gated channel 1; BCNG-1,890,98930,8.54,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08412:Ion_trans_N",HGNC:4845,Membrane,,"","",None,"147-167 174-194 220-240 249-269 301-321 345-366 372-392",Non Essential,1Q3E,HCN1,HCN1,AF064876,"","" 271,DNA repair protein complementing XP-A cells,2009-05-04 17:29:01 UTC,2009-06-30 03:51:46 UTC,P23025,"Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region","",">DNA repair protein complementing XP-A cells MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMANVKAAPKIID TGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLIT KTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQEN REKMKQKKFDKKVKELRRAVRSSVWKRETIVHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM",XPA,Xeroderma pigmentosum group A-complementing protein,273,31368,6.72,">>> Function: binding Function: nucleic acid binding Function: DNA binding Function: damaged DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA repair Process: nucleotide-excision repair || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF05181:XPA_C PF01286:XPA_N",HGNC:12814,Nucleus,,"","",None,None,Non Essential,1XPA,XPA,XPA,U16815,"","" 272,"Alkaline phosphatase, tissue-nonspecific isozyme",2009-05-04 22:15:10 UTC,2009-06-30 03:51:45 UTC,P05186,This isozyme may play a role in skeletal mineralization,"",">Alkaline phosphatase, tissue-nonspecific isozyme MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDP HNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACI GANLGHCAPASSAGSLAAGPLLLALALYPLSVLF",ALPL,AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme,524,57305,6.66,">>> Function: Not Available || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00245:Alk_phosphatase,HGNC:438,Cell membrane,,"","",1-17,None,Non Essential,"",ALPL,ALPL,BC126165,"","" 273,"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial",2009-05-05 15:57:35 UTC,2009-06-30 03:51:35 UTC,P08559,"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)","",">Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQT VRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTG RKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNM AALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPI LMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAA QFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS",PDHA1,PDHE1-A type I,390,43296,8.14,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Energy production and conversion,PF00676:E1_dh,HGNC:8806,Mitochondrion matrix,,"","",None,None,Non Essential,1NI4,PDHA1,PDHA1,AF125088,"","" 274,"Pyruvate dehydrogenase protein X component, mitochondrial",2009-05-05 15:58:40 UTC,2009-06-30 03:51:39 UTC,O00330,Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex,"",">Pyruvate dehydrogenase protein X component, mitochondrial MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKILMPSLSPTMEE GNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKH VEIPKDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTATGPRGI FTKEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFTEIPA SNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQDLVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSW DGEGPKQLPFIDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL GMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSF KANLENPIRLA",PDHX,Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; Lipoyl-containing pyruvate dehydrogenase complex component X; E3-binding protein; E3BP; proX,501,54123,9.09,">>> Function: binding Function: protein binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Energy production and conversion,"PF00198:2-oxoacid_dh PF00364:Biotin_lipoyl PF02817:E3_binding",HGNC:21350,Mitochondrion matrix,,"","",None,None,Non Essential,"",PDHX,PDHX,U79296,Chromosome:11,11p13 275,"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial",2009-05-05 15:59:07 UTC,2009-06-30 03:51:38 UTC,P11177,"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)","",">Pyruvate dehydrogenase E1 component subunit beta, mitochondrial MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVS RGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPV PIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPF EFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIE ASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDII FAIKKTLNI",PDHB,PDHE1-B,359,39234,6.63,"",Energy production and conversion,"PF02779:Transket_pyr PF02780:Transketolase_C",HGNC:8808,Mitochondrion matrix,,"","",None,None,Non Essential,1NI4,PDHB,PDHB,X57778,"","" 276,"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial",2009-05-05 16:00:38 UTC,2009-06-30 03:51:49 UTC,P10515,"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)","",">Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial MWRVCARRAQNVAPWAGLEARWTALQEVPGTPRVTSRSGPAPARRNSVTTGYGGVRALCGWTPSSGATPR NRLLLQLLGSPGRRYYSLPPHQKVPLPSLSPTMQAGTIARWEKKEGDKINEGDLIAEVETDKATVGFESL EECYMAKILVAEGTRDVPIGAIICITVGKPEDIEAFKNYTLDSSAAPTPQAAPAPTPAATASPPTPSAQA PGSSYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEG TRDVPLGTPLCIIVEKEADISAFADYRPTEVTDLKPQVPPPTPPPVAAVPPTPQPLAPTPSAPCPATPAG PKGRVFVSPLAKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPPTGPGMAPVPTGVF TDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEGRSKISVNDFIIKASALACLK VPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQG GTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQ WLAEFRKYLEKPITMLL",DLAT,Pyruvate dehydrogenase complex E2 subunit; PDC-E2; PDCE2; E2; Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; M2 antigen complex 70 kDa subunit,647,68997,7.94,">>> Function: binding Function: protein binding Function: acetyltransferase activity Function: S-acetyltransferase activity Function: dihydrolipoyllysine-residue acetyltransferase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: cellular metabolism Process: alcohol metabolism Process: monosaccharide metabolism Process: hexose metabolism Process: glucose metabolism Process: glucose catabolism Process: glycolysis Process: physiological process Process: metabolism || >>> Component: protein complex Component: pyruvate dehydrogenase complex",Energy production and conversion,"PF00198:2-oxoacid_dh PF00364:Biotin_lipoyl PF02817:E3_binding",HGNC:2896,Mitochondrion matrix,,"","",None,None,Non Essential,1FYC,DLAT,DLAT,Y00978,Chromosome:11,11q23.1 277,Tyrosine 3-monooxygenase,2009-05-05 17:41:42 UTC,2009-06-30 03:51:38 UTC,P07101,Plays an important role in the physiology of adrenergic neurons,"",">Tyrosine 3-monooxygenase MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTPRSPRFIGRRQ SLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAK IHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCHHL VTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACG EHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASS PMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKF DPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG",TH,Tyrosine 3-hydroxylase; TH,528,58525,6.25,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Function: tyrosine 3-monooxygenase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: amino acid derivative metabolism Process: biogenic amine metabolism Process: catecholamine metabolism Process: catecholamine biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: aromatic amino acid family metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00351:Biopterin_H,HGNC:11782,"",,"","",None,None,Non Essential,1TOH,TH,TH,M20911,Chromosome:11,11p15.5 278,Aromatic-L-amino-acid decarboxylase,2009-05-05 17:42:31 UTC,2009-06-30 03:51:46 UTC,P20711,"Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine","",">Aromatic-L-amino-acid decarboxylase MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTH WHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEG GGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIP SDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFI CPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQ IPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE",DDC,AADC; DOPA decarboxylase; DDC,480,53895,7.21,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: amino acid metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:2719,"",,"","",None,None,Non Essential,1JS3,DDC,DDC,S46516,"","" 279,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial",2009-05-05 19:48:02 UTC,2009-06-30 03:51:47 UTC,Q15120,"Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism","",">[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDN LLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFD PFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQ YYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKED LSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGV GTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ",PDK3,Pyruvate dehydrogenase kinase isoform 3,406,46939,8.61,">>> Function: kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: physiological process Process: metabolism Process: cellular metabolism Process: phosphorus metabolism Process: phosphate metabolism Process: phosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF02518:HATPase_c,HGNC:8811,Mitochondrion matrix,,"","",None,None,Non Essential,"",PDK3,PDK3,BC015948,"","" 280,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial",2009-05-05 19:48:27 UTC,2009-06-30 03:51:37 UTC,Q16654,"Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism","",">[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILK EIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIE YKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFEC SRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIV VLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNL YSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM",PDK4,Pyruvate dehydrogenase kinase isoform 4,411,46470,6.65,">>> Function: kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: physiological process Process: metabolism Process: cellular metabolism Process: phosphorus metabolism Process: phosphate metabolism Process: phosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF02518:HATPase_c,HGNC:8812,Mitochondrion matrix,,"","",None,None,Non Essential,"",PDK4,PDK4,BC040239,"","" 281,DNA (cytosine-5)-methyltransferase 1,2009-05-06 15:10:31 UTC,2009-06-30 03:51:34 UTC,P26358,Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2,"",">DNA (cytosine-5)-methyltransferase 1 MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRK EELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRR SKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSR ERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDE KDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHP PKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLC PIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMD PSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQ VESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLVYQIFDT FFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEAD DDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDS SKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPS ENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQKEIPRV LEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYI KGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAV VDFKAVQGRCTVEYGEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKP KSQACEPSEPEIEIKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTED CNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRP RFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEP LHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQL RGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSG ALRGVCSCVEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVL HPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKE EEAAKD",DNMT1,Dnmt1; MCMT; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; CXXC-type zinc finger protein 9,1616,183167,7.81,">>> Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: protein binding Function: transcription factor binding Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA modification Process: DNA alkylation Process: DNA methylation || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","Replication, recombination and repair","PF01426:BAH PF06464:DMAP_binding PF00145:DNA_methylase PF02008:zf-CXXC",HGNC:2976,Nucleus,,"","",None,None,Non Essential,"",DNMT1,DNMT1,AF169120,Chromosome:19,19p13.2 282,Cytochrome P450 1A2,2009-05-06 16:15:03 UTC,2009-06-30 03:51:36 UTC,P05177,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen","",">Cytochrome P450 1A2 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQ RYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLA QNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFP ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSV RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTV IGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVD LTPIYGLTMKHARCEHVQARRFSIN",CYP1A2,CYPIA2; P450-P3; P(3)450; P450 4,515,58295,9.43,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2596,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP1A2,CYP1A2,M55053,Chromosome:15,15q24.1 283,Cytochrome P450 3A4,2009-05-06 16:15:56 UTC,2009-06-30 03:51:38 UTC,P08684,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide","",">Cytochrome P450 3A4 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGK VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKL LRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTV LQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVV LKVESRDGTVSGA",CYP3A4,Quinine 3-monooxygenase; CYPIIIA4; Nifedipine oxidase; Cytochrome P450 3A3; CYPIIIA3; HLp; Taurochenodeoxycholate 6-alpha-hydroxylase; NF-25; P450-PCN1,503,57344,8.25,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2637,Endoplasmic reticulum membrane,,"","",None,2-22,Non Essential,1TQN,CYP3A4,CYP3A4,AF209389,"","" 284,Cytochrome P450 3A5,2009-05-06 16:16:11 UTC,2009-06-30 03:51:41 UTC,P20815,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics","",">Cytochrome P450 3A5 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGK MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKF LKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQN SKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAV VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL KVDSRDGTLSGE",CYP3A5,CYPIIIA5; P450-PCN3; HLp2,502,57109,9.09,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2638,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP3A5,CYP3A5,S74700,"","" 285,Cytochrome P450 3A43,2009-05-06 16:16:30 UTC,2009-06-30 03:51:47 UTC,Q9HB55,Exhibits low testosterone 6-beta-hydroxylase activity,"",">Cytochrome P450 3A43 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGE MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSV KFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL LKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDAL VQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIV LKVHLRDGITSGP",CYP3A43,"",503,57671,8.25,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:17450,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP3A43,CYP3A43,AY390426,"","" 286,Cytochrome P450 3A7,2009-05-06 16:16:45 UTC,2009-06-30 03:51:49 UTC,P24462,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics","",">Cytochrome P450 3A7 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRK VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSG KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKL LRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQN SKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTV LQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWREPEKFLPERFS KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIV LKAESRDETVSGA",CYP3A7,CYPIIIA7; P450-HFLA,503,57526,9.59,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2640,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP3A7,CYP3A7,BC067436,"","" 287,"Alkaline phosphatase, placental type",2009-05-06 16:34:31 UTC,2009-06-30 03:51:43 UTC,P05187,A phosphate monoester + H(2)O = an alcohol + phosphate,"",">Alkaline phosphatase, placental type MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVST VTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARF NQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIAT QLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASL DPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRAL TETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG YVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACL EPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP",ALPP,PLAP-1; Alkaline phosphatase Regan isozyme,535,57954,6.24,">>> Function: Not Available || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00245:Alk_phosphatase,HGNC:439,Cell membrane,,"","",1-22,513-529,Non Essential,1EW2,ALPP,ALPP,M12551,"","" 288,Intestinal alkaline phosphatase,2009-05-06 16:34:59 UTC,2009-06-30 03:51:48 UTC,P09923,A phosphate monoester + H(2)O = an alcohol + phosphate,"",">Intestinal alkaline phosphatase MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTA TRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQC NTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLI SNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQS VTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEA VMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVF NSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPY TACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP",ALPI,IAP,528,56813,5.70,">>> Function: Not Available || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00245:Alk_phosphatase,HGNC:437,Cell membrane,,"","",1-19,None,Non Essential,"",ALPI,ALPI,M19161,"","" 289,Parathyroid hormone,2009-05-06 17:04:57 UTC,2009-06-30 03:51:38 UTC,P01270,PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion,"",">Parathyroid hormone MIPAKDMAKVMIVMLAICFLTKSDGKSVKKRSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGA PLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ",PTH,PTH; Parathyrin; Parathormone,115,12861,10.49,">>> Function: signal transducer activity Function: receptor binding Function: hormone activity || >>> Process: Not Available || >>> Component: extracellular region","",PF01279:Parathyroid,HGNC:9606,Secreted,,"","",1-25,None,Non Essential,1BWX,PTH,PTH,BC096145,Chromosome:11,11p15.3-p15.1 290,Tuberoinfundibular peptide of 39 residues,2009-05-06 17:05:38 UTC,2009-06-30 03:51:49 UTC,Q96A98,"Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits","",">Tuberoinfundibular peptide of 39 residues METRQVSRSPRVRLLLLLLLLLVVPWGVRTASGVALPPVGVLSLRPPGRAWADPATPRPRRSLALADDAA FRERARLLAALERRHWLNSYMHKLLVLDAP",PTH2,TIP39; Parathyroid hormone 2,100,11202,12.33,"","","",HGNC:30828,Secreted,,"","",1-30,None,Non Essential,"",PTH2,PTH2,AY048588,Chromosome:19,19q13.33 291,Parathyroid hormone 2 receptor,2009-05-06 17:06:05 UTC,2009-06-30 03:51:45 UTC,P49190,This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity),"",">Parathyroid hormone 2 receptor MAGLGASLHVWGWLMLGSCLLARAQLDSDGTITIEEQIVLVLKAKVQCELNITAQLQEGEGNCFPEWDGL ICWPRGTVGKISAVPCPPYIYDFNHKGVAFRHCNPNGTWDFMHSLNKTWANYSDCLRFLQPDISIGKQEF FERLYVMYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHMHLFVSFMLRATSIFVKDRVVHAHIGVKEL ESLIMQDDPQNSIEATSVDKSQYIGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVAFFSDTKYLWGFI LIGWGFPAAFVAAWAVARATLADARCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAV GHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFTGLGWEIRMHCELFFNSFQGFFVSIIYCYCNGEV QAEVKKMWSRWNLSVDWKRTPPCGSRRCGSVLTTVTHSTSSQSQVAASTRMVLISGKAAKIASRQPDSHI TLPGYVWSNSEQDCLPHSFHEETKEDSGRQGDDILMEKPSRPMESNPDTEGCQGETEDVL",PTH2R,PTH2 receptor,550,62236,7.09,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF00002:7tm_2 PF02793:HRM",HGNC:9609,Cell membrane,,"","",1-24,"146-169 177-196 238-260 276-297 317-337 365-383 395-417",Non Essential,"",PTH2R,PTH2R,U47129,"","" 293,Sodium-dependent phosphate transporter 1,2009-05-06 17:35:38 UTC,2009-06-30 03:51:41 UTC,Q8WUM9,"Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV)","",">Sodium-dependent phosphate transporter 1 MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFE TVGSVLLGAKVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGF SLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADPVPNGLRALPVFYACTVGINL FSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLKE DHEETKLSVGDIENKHPVSEVGPATVPLQAVVEERTVSFKLGDLEEAPERERLPSVDLKEETSIDSTVNG AVQLPNGNLVQFSQAVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTS YTMAICGMPLDSFRAKEGEQKGEEMEKLTWPNADSKKRIRMDSYTSYCNAVSDLHSASEIDMSVKAEMGL GDRKGSNGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYDTGDVSSKVAT PIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSV VSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVILRM",SLC20A1,Solute carrier family 20 member 1; Phosphate transporter 1; PiT-1; Gibbon ape leukemia virus receptor 1; GLVR-1; Leukemia virus receptor 1 homolog,679,73700,7.08,">>> Function: transporter activity Function: ion transporter activity Function: anion transporter activity Function: inorganic anion transporter activity Function: phosphate transporter activity Function: inorganic phosphate transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: phosphate transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,PF01384:PHO4,HGNC:10946,Membrane,,"","",None,"21-41 62-82 100-120 158-178 203-223 230-250 511-531 558-578 600-620 650-670",Non Essential,"",SLC20A1,SLC20A1,AF102063,"","" 294,Apolipoprotein D,2009-05-06 19:12:37 UTC,2009-06-30 03:51:50 UTC,P05090,APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts,"",">Apolipoprotein D MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTFENGRCIQANYSLME NGKIKVLNQELRADGTVNQIEGEATPVNLTEPAKLEVKFSWFMPSAPYWILATDYENYALVYSCTCIIQL FHVDFAWILARNPNLPPETVDSLKNILTSNNIDVKKMTVTDQVNCPKLS",APOD,Apo-D; ApoD,189,21276,4.79,">>> Function: isoprenoid binding Function: retinoid binding Function: transporter activity Function: binding Function: lipid binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available",Cell wall/membrane/envelope biogenesis,PF00061:Lipocalin,HGNC:612,Secreted,,"","",1-20,None,Non Essential,"",APOD,APOD,S80440,"","" 295,"Superoxide dismutase [Mn], mitochondrial",2009-05-06 21:00:26 UTC,2009-06-30 03:51:42 UTC,P04179,Destroys radicals which are normally produced within the cells and which are toxic to biological systems,"",">Superoxide dismutase [Mn], mitochondrial MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQ EALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASV GVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINW ENVTERYMACKK",SOD2,"",222,24722,8.45,">>> Function: binding Function: ion binding Function: metal ion binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on superoxide radicals as acceptor Function: superoxide dismutase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: superoxide metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,"PF02777:Sod_Fe_C PF00081:Sod_Fe_N",HGNC:11180,Mitochondrion matrix,,"","",None,None,Non Essential,1LUV,SOD2,SOD2,BC012423,"","" 296,Extracellular superoxide dismutase [Cu-Zn],2009-05-06 21:00:49 UTC,2009-06-30 03:51:41 UTC,P08294,Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen,"",">Extracellular superoxide dismutase [Cu-Zn] MLALLCSCLLLAAGASDAWTGEDSAEPNSDSAEWIRDMYAKVTEIWQEVMQRRDDDGALHAACQVQPSAT LDAAQPRVTGVVLFRQLAPRAKLDAFFALEGFPTEPNSSSRAIHVHQFGDLSQGCESTGPHYNPLAVPHP QHPGDFGNFAVRDGSLWRYRAGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVV GVCGPGLWERQAREHSERKKRRRESECKAA",SOD3,EC-SOD,240,25851,6.59,">>> Function: binding Function: ion binding Function: metal ion binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on superoxide radicals as acceptor Function: superoxide dismutase activity Function: copper, zinc superoxide dismutase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: superoxide metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00080:Sod_Cu,HGNC:11181,"Secreted, extracellular space",,"","",1-18,None,Non Essential,"",SOD3,SOD3,BC014418,"","" 297,Xanthine dehydrogenase/oxidase,2009-05-06 21:15:11 UTC,2009-06-30 03:51:39 UTC,P47989,This enzyme can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups,"",">Xanthine dehydrogenase/oxidase MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSA NACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIE NAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCCMNQKKDHSVSLSPSLFKPEEFTPLDPTQEP IFPPELLRLKDTPRKQLRFEGERVTWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVC PAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGG NIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSA FKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGL AEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLDPTFASATLLFQKDPPADVQL FQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVP GFVCFISADDVPGSNITGICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIE DAIKNNSFYGPELKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNT MKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGR HPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNT AFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEGFTLPRCWEECLASSQYHA RKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQV ASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTA AYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPA IDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAV GEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPATPEKIRNACVDKFTTLCVTGVPENCKPWS VRV",XDH,Xanthine dehydrogenase; XD; Xanthine oxidase; XO; Xanthine oxidoreductase,1333,146426,7.70,">>> Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: transporter activity Function: electron transporter activity Function: binding Function: ion binding Function: metal ion binding Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Nucleotide transport and metabolism,"PF01315:Ald_Xan_dh_C PF02738:Ald_Xan_dh_C2 PF03450:CO_deh_flav_C PF00941:FAD_binding_5 PF00111:Fer2 PF01799:Fer2_2",HGNC:12805,Peroxisome,,"","",None,None,Non Essential,1V97,XDH,XDH,DQ089481,"","" 298,"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",2009-05-06 21:19:02 UTC,2009-06-30 03:51:49 UTC,P31040,Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q),"",">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDHEFDAVVVGAG GAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIH YMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLR YDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMI TRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLE IREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQ VLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGE ESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNT DLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYV DVGTGKVTLEYRPVIDKTLNEADCATVPPAIRSY",SDHA,Flavoprotein subunit of complex II; Fp,664,72692,7.41,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: oxidoreductase activity, acting on the CH-CH group of donors Function: catalytic activity Function: oxidoreductase activity || >>> Process: energy derivation by oxidation of organic compounds Process: main pathways of carbohydrate metabolism Process: tricarboxylic acid cycle Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,"PF00890:FAD_binding_2 PF02910:Succ_DH_flav_C",HGNC:10680,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",SDHA,SDHA,S79641,"","" 299,"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial",2009-05-06 21:19:24 UTC,2009-06-30 03:51:48 UTC,P21912,Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q),"",">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGP MVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLV PDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPA VLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV",SDHB,Iron-sulfur subunit of complex II; Ip,280,31630,8.92,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: transporter activity Function: electron transporter activity || >>> Process: energy derivation by oxidation of organic compounds Process: main pathways of carbohydrate metabolism Process: tricarboxylic acid cycle Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane",Energy production and conversion,PF00111:Fer2,HGNC:10681,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",SDHB,SDHB,M32246,"","" 300,"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial",2009-05-06 21:19:48 UTC,2009-06-30 03:51:39 UTC,Q99643,Mono-heme cytochrome b. May act as a mediator of low potential couples in an electron flow through cardiac complex II. Is involved in system II of the mitochondrial electron transport chain which is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q),"",">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYSWSLPMAMSIC HRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFALVFPLMYHTWNGIRHLMWDLG KGLKIPQLYQSGVVVLVLTVLSSMGLAAM",SDHC,Succinate dehydrogenase complex subunit C; Integral membrane protein CII-3; QPs-1; QPs1; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL,169,18611,10.12,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-CH group of donors Function: succinate dehydrogenase activity || >>> Process: electron transport Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: energy derivation by oxidation of organic compounds Process: main pathways of carbohydrate metabolism Process: tricarboxylic acid cycle || >>> Component: cell Component: membrane",Energy production and conversion,PF01127:Sdh_cyt,HGNC:10682,Mitochondrion inner membrane,,"","",None,"71-93 105-127 147-168",Non Essential,"",SDHC,SDHC,BC066329,"","" 301,"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial",2009-05-06 21:20:10 UTC,2009-06-30 03:51:45 UTC,O14521,Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity),"",">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSKAASLHWTSER VVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDALQKAAKAGLLALSALTFAGLC YFNYHDVGICKAVAMLWKL",SDHD,CybS; Succinate-ubiquinone reductase membrane anchor subunit; QPs3; CII-4; Succinate dehydrogenase complex subunit D; Succinate-ubiquinone oxidoreductase cytochrome b small subunit,159,17043,8.75,">>> Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: electron transport Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: energy derivation by oxidation of organic compounds Process: main pathways of carbohydrate metabolism Process: tricarboxylic acid cycle || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane Component: envelope Component: organelle envelope Component: mitochondrial envelope","",PF05328:CybS,HGNC:10683,Mitochondrion inner membrane,,"","",None,"64-85 91-111 121-142",Non Essential,"",SDHD,SDHD,BC071756,Chromosome:11,11q23 302,Adenylate cyclase type 1,2009-05-07 15:07:47 UTC,2009-06-30 03:51:42 UTC,Q08828,This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning,"",">Adenylate cyclase type 1 MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAATLKALAVLSL LAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPF ALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRL WRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMK EDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKIL GDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS NDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRKIFPGLIL SDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTT PGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLI FPQSVVVLLLLVFCICFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWS SKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELS GYTRTGGGAVSGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNL LPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEK DFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGIN VGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEML TYFLEGRTDGNGSQIRSLGLDRKMCPFGRAGLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA",ADCY1,Adenylate cyclase type I; ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase,1119,123442,8.49,">>> Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available",Signal transduction mechanisms,PF00211:Guanylate_cyc,HGNC:232,Membrane,,"","",None,"64-84 88-108 125-145 158-178 183-203 214-234 611-631 635-655 674-694 725-745 753-773 775-794",Non Essential,"",ADCY1,ADCY1,L05500,"","" 303,Adenylate cyclase type 2,2009-05-07 15:08:05 UTC,2009-06-30 03:51:43 UTC,Q08462,"This is a membrane-bound, calmodulin-insensitive adenylyl cyclase","",">Adenylate cyclase type 2 MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGL EVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFF LFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKH LMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHN LYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPIS LPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRA SVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQA IDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFF LSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVAL VGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKK EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGL ECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFAL VGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVL QTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNVAS",ADCY2,Adenylate cyclase type II; ATP pyrophosphate-lyase 2; Adenylyl cyclase 2,1091,123605,8.15,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:233,Membrane,,"","",None,"46-66 76-96 108-128 133-153 159-179 187-207 602-622 628-652 680-701 734-755 763-780 801-821",Non Essential,1AB8,ADCY2,ADCY2,L21993,"","" 304,Adenylate cyclase type 3,2009-05-07 15:08:30 UTC,2009-06-30 03:51:37 UTC,O60266,Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration,"",">Adenylate cyclase type 3 MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYF KRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLP YVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVA QQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLML SILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFAR FDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETY LIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSF PNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEK QSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDR TRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQ VSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKY SMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKR DEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGST YMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVL AGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLK GRDKLATFPNGPSVTLPHQVVDNS",ADCY3,"Adenylate cyclase type III; AC-III; ATP pyrophosphate-lyase 3; Adenylyl cyclase 3; AC3; Adenylate cyclase, olfactive type",1144,128962,6.55,">>> Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available",Signal transduction mechanisms,PF00211:Guanylate_cyc,HGNC:234,Membrane,,"","",None,"80-100 105-125 139-159 173-193 226-246 381-401 633-653 664-684 708-728 754-774 775-795 833-853",Non Essential,"",ADCY3,ADCY3,AB011083,"","" 305,Adenylate cyclase type 4,2009-05-07 15:08:47 UTC,2009-06-30 03:51:45 UTC,Q8NFM4,"This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)","",">Adenylate cyclase type 4 MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALG GFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGMRD AAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSL HSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIV GFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCR AIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG AYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKP FAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDF NPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILFVC FSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSS MISNLSWELPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLI VRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRL LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFD ELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNN FRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIK VKGKGQLCTYFLNTDLTRTGPPSATLG",ADCY4,Adenylate cyclase type IV; ATP pyrophosphate-lyase 4; Adenylyl cyclase 4,1077,119796,7.50,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:235,Membrane,,"","",None,"29-50 61-80 94-117 120-138 141-162 170-190 586-607 611-633 664-687 715-736 744-764 791-807",Non Essential,"",ADCY4,ADCY4,BC117475,Chromosome:14,14q12 306,Adenylate cyclase type 5,2009-05-07 15:09:01 UTC,2009-06-30 03:51:42 UTC,O95622,"This is a membrane-bound, calcium-inhibitable adenylyl cyclase","",">Adenylate cyclase type 5 MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLA SRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSA AAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCL ALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGV ILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAA VLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL VMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVN MRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNA YLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFED PKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASL VFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYF TYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEH ATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAA HFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLE KIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIG ARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL S",ADCY5,Adenylate cyclase type V; ATP pyrophosphate-lyase 5; Adenylyl cyclase 5,1261,138909,7.25,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:236,Membrane,,"","",None,"196-216 242-262 268-288 299-319 325-345 349-369 374-394 770-790 792-812 836-856 910-930 935-955 984-1004",Non Essential,1U0H,ADCY5,ADCY5,BK000371,"","" 307,Adenylate cyclase type 6,2009-05-07 15:09:18 UTC,2009-06-30 03:51:48 UTC,O43306,"Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)","",">Adenylate cyclase type 6 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAF IRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLY QRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWV VSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNR GDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHV AMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW QFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRK EEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR AIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGI YASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIR SCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALY LHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAV MFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQ VGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDST GVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS",ADCY6,Adenylate cyclase type VI; ATP pyrophosphate-lyase 6; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase,1168,130617,8.27,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:237,Membrane,,"","",None,"152-168 181-197 214-230 239-255 259-275 289-305 674-691 702-718 743-759 820-836 839-855 897-913",Non Essential,1U0H,ADCY6,ADCY6,BC064923,Chromosome:12,12q12-q13 308,Adenylate cyclase type 7,2009-05-07 15:09:35 UTC,2009-06-30 03:51:44 UTC,P51828,"This is a membrane-bound, calcium-inhibitable adenylyl cyclase","",">Adenylate cyclase type 7 MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAF LVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLL PFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFT YTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSI LYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKM GLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLES WGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTR PCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGLVAC VLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVG NETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCC GQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNE IIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINR HSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCEC RGLINVKGKGELRTYFVCTDTAKFQGLGLN",ADCY7,Adenylate cyclase type VII; ATP pyrophosphate-lyase 7; Adenylyl cyclase 7,1080,120310,8.16,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:238,Membrane,,"","",None,"34-54 63-83 95-117 122-142 147-167 176-196 595-615 620-640 669-688 718-737 746-773 794-814",Non Essential,"",ADCY7,ADCY7,BC126271,Chromosome:16,16q12-q13 309,Adenylate cyclase type 8,2009-05-07 15:09:52 UTC,2009-06-30 03:51:37 UTC,P40145,"This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity)","",">Adenylate cyclase type 8 MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASD PAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSD FFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDP LKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFA TYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAF LETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMI KTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLN GDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFD NIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSL EHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLI LRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG VLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLL AVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDA VGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEK QQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASR MDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQY SLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP",ADCY8,Adenylate cyclase type VIII; ATP pyrophosphate-lyase 8; Adenylyl cyclase 8; Ca(2+)/calmodulin-activated adenylyl cyclase,1251,140124,6.99,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:239,Membrane,,"","",None,"183-203 212-232 247-267 274-294 296-316 321-341 716-736 738-758 787-807 831-851 861-881 894-914",Non Essential,"",ADCY8,ADCY8,M83533,"","" 310,Adenylate cyclase type 9,2009-05-07 15:10:07 UTC,2009-06-30 03:51:36 UTC,O60503,May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity),"",">Adenylate cyclase type 9 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGG GRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRS RLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTAT ARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWE LLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQG DEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGV HTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVA DQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKG RWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEE VIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIR MVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYC NFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQ EVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTY SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGL NTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDT VNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISP DIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFGKAIEK DDCDETGIEEANELTKLNVSKSV",ADCY9,Adenylate cyclase type IX; ATP pyrophosphate-lyase 9; Adenylyl cyclase 9,1353,150702,7.35,">>> Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available",Signal transduction mechanisms,PF00211:Guanylate_cyc,HGNC:240,Membrane,,"","",None,"118-138 142-162 172-192 216-235 242-259 281-301 787-807 819-839 868-888 892-912 921-941 976-996",Non Essential,"",ADCY9,ADCY9,AY028959,Chromosome:16,16p13.3 311,Adenylate cyclase type 10,2009-05-07 15:10:20 UTC,2009-06-30 03:51:46 UTC,Q96PN6,"Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation","",">Adenylate cyclase type 10 MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQ LVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFETQEWEEGLD IRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQ RAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNK QLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGF PGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMY YPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMACLICNRKEDYPLLGRN KEINYFMYTMKKFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRIIAISLNKISFHQTFYTIQMF MANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIFHVQFPISREISRMSTLKKQKQLEILFMKIL KLIVKEERIIFIIDEAQFVDSTSWRFMEKLIRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVVGAV QPNDISNKICLDLNVSCISKELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFK YSIKLTEKLNMVTLHSDKESEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTF TTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLKPSEGMDHGEE EQLRELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEEDAHRCDHCRGRDFIPYHHFTV NIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAFFPENRSPEEIREKILNFFDHVLTKMKTSDE DIIPLESCQCEEILEIVILPLAHHFLALGENDKALYYFLEIASAYLIFCDNYMAYMYLNEGQKLLKTLKK DKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQ AQESPPPGKKRLAQLYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSL YHHLAGYKGVWFKYEVMAMEHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQ NPNRHYQSLCRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEECL EFIHQYENNRILKFHSGLLLGLYSSVAIWYARLQEWDNFYKFSNRAKNLLPRRTMTLTYYDGISRYMEGQ VLHLQKQIKEQSENAQASGEELLKNLENLVAQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRL SETQGNILEKCWLNMNKESWYSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFLMRANTVDNHF",ADCY10,Adenylate cyclase homolog; Testicular soluble adenylyl cyclase; Germ cell soluble adenylyl cyclase; hsAC; sAC; AH-related protein,1610,187138,7.32,">>> Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available",Signal transduction mechanisms,PF00211:Guanylate_cyc,HGNC:21285,Cell membrane,,"","",None,None,Non Essential,"",ADCY10,ADCY10,BC117372,"","" 312,Acetylcholinesterase,2009-05-07 15:14:35 UTC,2009-06-30 03:51:50 UTC,P22303,Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis,"",">Acetylcholinesterase MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAE PPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLA LQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRAT QLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAG DFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPL DPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQAC AFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL",ACHE,AChE,614,67797,6.24,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: carboxylic ester hydrolase activity Function: cholinesterase activity || >>> Process: Not Available || >>> Component: Not Available",Lipid transport and metabolism,"PF08674:AChE_tetra PF00135:COesterase",HGNC:108,Isoform H:Cell membrane,,"","",1-31,None,Non Essential,1F8U,ACHE,ACHE,AF312032,"","" 313,NF-kappa-B essential modulator,2009-05-07 20:37:40 UTC,2009-06-30 03:51:39 UTC,Q9Y6K9,Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa- B-mediated protection from cytokine toxicity (By similarity),"",">NF-kappa-B essential modulator MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQ ILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKA SVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVE AALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEV IDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQES ARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE",IKBKG,NEMO; NF-kappa-B essential modifier; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IkB kinase subunit gamma; I-kappa-B kinase gamma; IKK-gamma; IKKG; IkB kinase-associated protein 1; IKKAP1; FIP-3,419,48198,5.46,"","Replication, recombination and repair","",HGNC:5961,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",IKBKG,IKBKG,BC050612,"","" 314,Inhibitor of nuclear factor kappa-B kinase subunit alpha,2009-05-07 20:38:07 UTC,2009-06-30 03:51:43 UTC,O15111,"Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF- kappa-B-regulated promoters during inflammatory responses triggered by cytokines","",">Inhibitor of nuclear factor kappa-B kinase subunit alpha MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNH ANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKI IHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTM VFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENWLQLML NWDPQQRGGPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTG SQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLD LERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESL EQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALS NIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTP QDGETSAQMIEENLNCLGHLSTIIHEANEEQGNSMMNLDWSWLTE",CHUK,I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA,745,84655,6.72,">>> Function: protein serine/threonine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:1974,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",CHUK,CHUK,U22512,Chromosome:10,10q24-q25 315,Inhibitor of nuclear factor kappa-B kinase subunit beta,2009-05-07 20:38:23 UTC,2009-06-30 03:51:44 UTC,O14920,Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3,"",">Inhibitor of nuclear factor kappa-B kinase subunit beta MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTH PNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENR IIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGT LAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLM LMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEED QELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSI QIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTL DDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVE EVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPE PAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS",IKBKB,I-kappa-B-kinase beta; IkBKB; IKK-beta; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB,756,86565,5.53,">>> Function: protein serine/threonine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","","PF00069:Pkinase PF00240:ubiquitin",HGNC:5960,Cytoplasm,,"","",None,None,Non Essential,"",IKBKB,IKBKB,BC006231,"","" 316,Inhibitor of nuclear factor kappa-B kinase subunit epsilon,2009-05-07 20:38:56 UTC,2009-06-30 03:51:35 UTC,Q14164,Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response,"",">Inhibitor of nuclear factor kappa-B kinase subunit epsilon MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKL FAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGN IMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVT LYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPI LANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQ EYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELK AAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKS RMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAA CNTEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDN NRIIERLNRVPAPPDV",IKBKE,I kappa-B kinase epsilon; IkBKE; IKK-epsilon; IKK-E; Inducible I kappa-B kinase; IKK-i,716,80463,7.90,">>> Function: protein serine/threonine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:14552,Cytoplasm (Probable),,"","",None,None,Non Essential,"",IKBKE,IKBKE,BC105924,"","" 317,"Thioredoxin, mitochondrial",2009-05-07 21:45:08 UTC,2009-06-30 03:51:37 UTC,Q99757,Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity,"",">Thioredoxin, mitochondrial MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDF QDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMK NGDVVDKFVGIKDEDQLEAFLKKLIG",TXN2,Mt-Trx; MTRX; Thioredoxin-2,166,18384,8.49,">>> Function: transporter activity Function: electron transporter activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00085:Thioredoxin,HGNC:17772,Mitochondrion,,"","",None,None,Non Essential,"",TXN2,TXN2,BC050610,Chromosome:22,22q13.1 318,Apolipoprotein A-I,2009-05-07 22:00:09 UTC,2009-06-30 03:51:45 UTC,P02647,Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT),"",">Apolipoprotein A-I MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKL LDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYR QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGG ARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ",APOA1,Apo-AI; ApoA-I; Contains: RecName: Apolipoprotein A-I(1-242),267,30778,5.50,">>> Function: binding Function: lipid binding || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: lipoprotein metabolism Process: physiological process Process: cellular physiological process Process: transport Process: lipid transport || >>> Component: extracellular region","",PF01442:Apolipoprotein,HGNC:600,Secreted,,"","",1-18,None,Non Essential,1AV1,APOA1,APOA1,BC110286,Chromosome:11,11q23-q24 319,Fatty aldehyde dehydrogenase,2009-05-07 22:06:07 UTC,2009-06-30 03:51:48 UTC,P51648,Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length,"",">Fatty aldehyde dehydrogenase MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDF MLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELS ENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGG KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYE RIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAIN FINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY",ALDH3A2,Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10; Microsomal aldehyde dehydrogenase,485,54849,7.99,"",Energy production and conversion,PF00171:Aldedh,HGNC:403,Endoplasmic reticulum membrane,,"","",None,464-480,Non Essential,"",ALDH3A2,ALDH3A2,BC002430,Chromosome:17,17p11.2 320,"Aldehyde dehydrogenase, mitochondrial",2009-05-07 22:06:23 UTC,2009-06-30 03:51:50 UTC,P05091,An aldehyde + NAD(+) + H(2)O = an acid + NADH,"",">Aldehyde dehydrogenase, mitochondrial MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAE GDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLD MVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKV AEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLK RVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGN PFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGS GRELGEYGLQAYTEVKTVTVKVPQKNS",ALDH2,ALDH class 2; ALDHI; ALDH-E2,517,56382,7.05,"",Energy production and conversion,PF00171:Aldedh,HGNC:404,Mitochondrion matrix,,"","",None,None,Non Essential,1OF7,ALDH2,ALDH2,M54931,Chromosome:12,12q24.2 321,"Aldehyde dehydrogenase, dimeric NADP-preferring",2009-05-07 22:06:44 UTC,2009-06-30 03:51:34 UTC,P30838,"ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes","",">Aldehyde dehydrogenase, dimeric NADP-preferring MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEE IEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPS ELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLE LGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSR DYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH",ALDH3A1,Aldehyde dehydrogenase family 3 member A1; Aldehyde dehydrogenase 3; ALDHIII,453,50380,6.52,"",Energy production and conversion,PF00171:Aldedh,HGNC:405,Cytoplasm,,"","",None,None,Non Essential,"",ALDH3A1,ALDH3A1,BC021194,Chromosome:17,17p11.2 322,Retinal dehydrogenase 1,2009-05-07 22:07:01 UTC,2009-06-30 03:51:41 UTC,P00352,Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity),"",">Retinal dehydrogenase 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQA FQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI QGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIK EAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLA DADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQ YDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVK TVTVKISQKNS",ALDH1A1,"RALDH 1; RalDH1; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; ALHDII; ALDH-E1",501,54862,6.71,"",Energy production and conversion,PF00171:Aldedh,HGNC:402,Cytoplasm,,"","",None,None,Non Essential,1BXS,ALDH1A1,ALDH1A1,K03000,"","" 323,Aldehyde dehydrogenase family 3 member B2,2009-05-07 22:07:19 UTC,2009-06-30 03:51:37 UTC,P48448,An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H,"",">Aldehyde dehydrogenase family 3 member B2 MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGNCVVLKPSEISQGTEKVLA EVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGGKNPCYVDD NCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQF QRLRALLGCGRVAIGGQSNESDRYIAPTVLVDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKP LALYAFSNSSQVVNQMLERTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLA PSGLEKLKEIRYPPYTDWNQQLLRWGMGSQSCTLL",ALDH3B2,Aldehyde dehydrogenase 8,385,42670,5.97,"",Energy production and conversion,PF00171:Aldedh,HGNC:411,"",,"","",None,None,Non Essential,"",ALDH3B2,ALDH3B2,BC007685,Chromosome:11,11q13 324,"Aldehyde dehydrogenase X, mitochondrial",2009-05-07 22:07:36 UTC,2009-06-30 03:51:36 UTC,P30837,"ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation","",">Aldehyde dehydrogenase X, mitochondrial MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAE GDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLASLETLDNGKPFQESYALDLD EVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKV AEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLK RVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGN PFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGN GRELGEDGLKAYTEVKTVTIKVPQKNS",ALDH1B1,Aldehyde dehydrogenase family 1 member B1; Aldehyde dehydrogenase 5,517,57239,6.79,"",Energy production and conversion,PF00171:Aldedh,HGNC:407,Mitochondrion matrix,,"","",None,None,Non Essential,"",ALDH1B1,ALDH1B1,BC001619,"","" 325,4-trimethylaminobutyraldehyde dehydrogenase,2009-05-07 22:07:50 UTC,2009-06-30 03:51:49 UTC,P49189,Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction,"",">4-trimethylaminobutyraldehyde dehydrogenase MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSG MERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFG YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQ GGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMAN FLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQG AKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDV ESAF",ALDH9A1,TMABADH; Aldehyde dehydrogenase family 9 member A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R-aminobutyraldehyde dehydrogenase,494,53802,5.61,"",Energy production and conversion,PF00171:Aldedh,HGNC:412,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",ALDH9A1,ALDH9A1,X75425,"","" 326,Aldehyde dehydrogenase family 8 member A1,2009-05-07 22:08:07 UTC,2009-06-30 03:51:50 UTC,Q9H2A2,"Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro)","",">Aldehyde dehydrogenase family 8 member A1 MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERS RVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYT VRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGT GPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSF ANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGA QIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH",ALDH8A1,Aldehyde dehydrogenase 12,487,53402,7.16,"",Energy production and conversion,PF00171:Aldedh,HGNC:15471,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",ALDH8A1,ALDH8A1,BC114473,"","" 327,Aldehyde dehydrogenase family 3 member B1,2009-05-07 22:08:19 UTC,2009-06-30 03:51:43 UTC,P43353,An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H,"",">Aldehyde dehydrogenase family 3 member B1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQGE VTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPS EISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLE LGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSP NLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDE AIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL",ALDH3B1,Aldehyde dehydrogenase 7,468,51840,7.67,"",Energy production and conversion,PF00171:Aldedh,HGNC:410,"",,"","",None,None,Non Essential,"",ALDH3B1,ALDH3B1,BC033099,Chromosome:11,11q13 328,Aldehyde dehydrogenase 1A3,2009-05-07 22:08:38 UTC,2009-07-22 22:35:13 UTC,P47895,Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity),"",">Aldehyde dehydrogenase family 1 member A3 MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPD VDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRT LRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTP LTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLE LGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVK TEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELG EYALAEYTEVKTVTIKLGDKNP",ALDH1A3,Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3,512,56109,7.29,"",Energy production and conversion,PF00171:Aldedh,HGNC:409,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",ALDH1A3,ALDH1A3,BC069274,Chromosome:15,15q26.3 329,"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial",2009-05-07 22:08:50 UTC,2009-06-30 03:51:41 UTC,P30038,"Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes","",">Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGD EEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRR AEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPF NFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLC GINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSA CSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVV QEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYA YMQ",ALDH4A1,P5C dehydrogenase; Aldehyde dehydrogenase family 4 member A1,563,61720,8.20,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-NH group of donors Function: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Function: 1-pyrroline-5-carboxylate dehydrogenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: glutamine family amino acid metabolism Process: proline metabolism Process: proline biosynthesis || >>> Component: membrane-enclosed lumen Component: organelle lumen Component: mitochondrial lumen Component: mitochondrial matrix",Energy production and conversion,PF00171:Aldedh,HGNC:406,Mitochondrion matrix,,"","",None,None,Non Essential,"",ALDH4A1,ALDH4A1,BC023600,"","" 330,"Succinate-semialdehyde dehydrogenase, mitochondrial",2009-05-07 22:09:05 UTC,2009-06-30 03:51:43 UTC,P51649,Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH,"",">Succinate-semialdehyde dehydrogenase, mitochondrial MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWL PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLAR IITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAM ITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKI SFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMV GVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL",ALDH5A1,NAD(+)-dependent succinic semialdehyde dehydrogenase; Aldehyde dehydrogenase family 5 member A1,535,57215,8.37,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Function: aldehyde dehydrogenase activity || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,PF00171:Aldedh,HGNC:408,Mitochondrion,,"","",None,None,Non Essential,"",ALDH5A1,ALDH5A1,L34820,"","" 331,Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2,2009-05-07 22:09:19 UTC,2009-06-30 03:51:39 UTC,Q3SY69,10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH,"",">Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2 MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGKADPLALAAEK DGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASA INWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAVQLIADGKA PRIPQPEEGATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGE PLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKV IWAGILSNVPIIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGED QEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAK DAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDK IQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKF AELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSP LIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQ NHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGD IDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEAL NEYLKTKTVTLEY",ALDH1L2,Aldehyde dehydrogenase family 1 member L2,923,101747,6.47,">>> Function: vitamin binding Function: phosphopantetheine binding Function: binding Function: cofactor binding Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: glycine hydroxymethyltransferase activity Function: hydroxymethyl-, formyl- and related transferase activity Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-NH group of donors Function: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Function: formyltetrahydrofolate dehydrogenase activity || >>> Process: biosynthesis Process: aromatic compound metabolism Process: folic acid and derivative metabolism Process: 10-formyltetrahydrofolate metabolism Process: 10-formyltetrahydrofolate catabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: cell Component: intracellular Component: cytoplasm",Energy production and conversion,"PF00171:Aldedh PF02911:Formyl_trans_C PF00551:Formyl_trans_N",HGNC:26777,"",,"","",None,None,Non Essential,"",ALDH1L2,ALDH1L2,CR749561,Chromosome:12,12q23.3 332,Retinal dehydrogenase 2,2009-05-07 22:09:36 UTC,2009-06-30 03:51:47 UTC,O94788,"Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity)","",">Retinal dehydrogenase 2 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQ EADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDL QGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIK PAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNL KRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSG NGREMGEFGLREYSEVKTVTVKIPQKNS",ALDH1A2,RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II),518,56725,5.84,"",Energy production and conversion,PF00171:Aldedh,HGNC:15472,Cytoplasm,,"","",None,None,Non Essential,1BI9,ALDH1A2,ALDH1A2,AL110299,Chromosome:15,15q22.1 333,Alpha-aminoadipic semialdehyde dehydrogenase,2009-05-07 22:09:51 UTC,2009-06-30 03:51:35 UTC,P49419,L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H,"",">Alpha-aminoadipic semialdehyde dehydrogenase MSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREA WKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPI LPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVL EDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFED ADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAV SMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWN NEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMR RSTCTINYSKDLPLAQGIKFQ",ALDH7A1,Alpha-AASA dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenease; P6c dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1,511,55367,6.86,"",Energy production and conversion,PF00171:Aldedh,HGNC:877,"",,"","",None,None,Non Essential,"",ALDH7A1,ALDH7A1,AF002696,"","" 334,10-formyltetrahydrofolate dehydrogenase,2009-05-07 22:10:35 UTC,2009-06-30 03:51:47 UTC,O75891,10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH,"",">10-formyltetrahydrofolate dehydrogenase MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWRAKGQALPDVV AKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFSIFWADDG LDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGKAPRLPQPEEGATYEGIQKKETAK INWDQPAEAIHNWIRGNDKVPGAWTEACEQKLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILF GNDDKMLLVKNIQLEDGKMILASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKS GAASVDVVRLVEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRM PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMY RLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTR KEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSG SLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVF FNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGA TLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFEY",ALDH1L1,10-FTHFDH; Aldehyde dehydrogenase family 1 member L1,902,98830,5.76,">>> Function: vitamin binding Function: phosphopantetheine binding Function: binding Function: cofactor binding Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: glycine hydroxymethyltransferase activity Function: hydroxymethyl-, formyl- and related transferase activity Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-NH group of donors Function: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Function: formyltetrahydrofolate dehydrogenase activity || >>> Process: biosynthesis Process: aromatic compound metabolism Process: folic acid and derivative metabolism Process: 10-formyltetrahydrofolate metabolism Process: 10-formyltetrahydrofolate catabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: cell Component: intracellular Component: cytoplasm",Energy production and conversion,"PF00171:Aldedh PF02911:Formyl_trans_C PF00551:Formyl_trans_N",HGNC:3978,Cytoplasm,,"","",None,None,Non Essential,1S3I,ALDH1L1,ALDH1L1,AF052732,"","" 335,Delta-1-pyrroline-5-carboxylate synthetase,2009-05-07 22:11:00 UTC,2009-06-30 03:51:41 UTC,P54886,ATP + L-glutamate = ADP + L-glutamate 5- phosphate,"",">Delta-1-pyrroline-5-carboxylate synthetase MLSQVYRCGFQPFNQHLLPWVKCTTVFRSHCIQPSVIRHVRSWSNIPFITVPLSRTHGKSFAHRSELKHA KRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQA LHSGQNQLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHEL LRMNIVPIVNTNDAVVPPAEPNSDLQGVNVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDD AKLIDIFYPGDQQSVTFGTKSRVGMGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVG TFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEILLANKKDLEEAEGRLAA PLLKRLSLSTSKLNSLAIGLRQIAASSQDSVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQV AALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAVQLVNTREEVEDLCRLDKMIDLIIPRGS SQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLF DQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLELCIEVVDNVQDAIDHIHKYGSSHTDVIV TEDENTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGKDHV VSDFSEHGSLKYLHENLPIPQRNTN",ALDH18A1,P5CS; Aldehyde dehydrogenase family 18 member A1; Glutamate 5-kinase; GK; Gamma-glutamyl kinase; Gamma-glutamyl phosphate reductase; GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase,795,87304,7.13,">>> Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: phosphotransferase activity, carboxyl group as acceptor Function: glutamate 5-kinase activity Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Function: glutamate-5-semialdehyde dehydrogenase activity || >>> Process: glutamine family amino acid metabolism Process: proline metabolism Process: proline biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: amino acid biosynthesis || >>> Component: cell Component: intracellular Component: cytoplasm",Amino acid transport and metabolism,PF00696:AA_kinase,HGNC:9722,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",ALDH18A1,ALDH18A1,BC117242,Chromosome:10,10q24.3 336,"Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial",2009-05-07 22:11:17 UTC,2009-06-30 03:51:47 UTC,Q02252,Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA,"",">Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGR VPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFR GLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKP SERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRV QANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQ PGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSS FRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR",ALDH6A1,MMSDH; Malonate-semialdehyde dehydrogenase [acylating]; Aldehyde dehydrogenase family 6 member A1,535,57840,8.69,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Function: methylmalonate-semialdehyde dehydrogenase (acylating) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: branched chain family amino acid metabolism Process: valine metabolism || >>> Component: Not Available",Energy production and conversion,PF00171:Aldedh,HGNC:7179,Mitochondrion,,"","",None,None,Non Essential,"",ALDH6A1,ALDH6A1,M93405,Chromosome:14,14q24.3 337,Aldehyde dehydrogenase family 16 member A1,2009-05-07 22:11:35 UTC,2009-06-30 03:51:38 UTC,Q8IZ83,"","",">Aldehyde dehydrogenase family 16 member A1 MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQDPITGENLAS CLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQ LAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLLL AQLAGELGPFPGILNVVSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLL LTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAAC DLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGT PARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRDSSGNLHGYVAE GGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKAAEAEVELSARR LRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACP LLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG CPRAWDQEAEGAGPELGLRVARTKALWLPMGD",ALDH16A1,"",802,85114,6.77,"",Energy production and conversion,PF00171:Aldedh,HGNC:28114,"",,"","",None,None,Non Essential,"",ALDH16A1,ALDH16A1,BC042142,Chromosome:19,19q13.33 338,Transient receptor potential cation channel subfamily A member 1,2009-05-07 22:28:22 UTC,2009-06-30 03:51:34 UTC,O75762,"Receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Also involved in pain sensation triggered by capsaicin, the pungent ingredient in chilli peppers. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity)","",">Transient receptor potential cation channel subfamily A member 1 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYA AAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQ GMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLNKGAKPCKSNKWGCFPIHQAAFSGS KECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAA TQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILAT ASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAA KNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGH AKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYL PECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNH PVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLI KTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFS MMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQV ELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYR LKDLTFLLEKQHELIKLIIQKMEIISETEDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP",TRPA1,Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120,1119,127489,7.08,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans",HGNC:497,Membrane,,"","",None,"720-740 773-793 806-826 830-850 874-894 941-961",Non Essential,"",TRPA1,TRPA1,Y10601,"","" 339,Cholinesterase,2009-05-08 15:36:43 UTC,2009-06-30 03:51:48 UTC,P06276,An acylcholine + H(2)O = choline + a carboxylate,"",">Cholinesterase MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLR FKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIW IYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNI AAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGC SRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVN KDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEI LSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEM TGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL",BCHE,Acylcholine acylhydrolase; Choline esterase II; Butyrylcholine esterase; Pseudocholinesterase,602,68419,7.47,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: carboxylic ester hydrolase activity Function: cholinesterase activity || >>> Process: Not Available || >>> Component: Not Available",Lipid transport and metabolism,"PF08674:AChE_tetra PF00135:COesterase",HGNC:983,Cytoplasmic,,"","",1-28,None,Non Essential,1P0Q,BCHE,BCHE,BC018141,"","" 340,Cytochrome P450 2C9,2009-05-08 16:33:12 UTC,2009-06-30 03:51:38 UTC,P11712,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan","",">Cytochrome P450 2C9 MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFG LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSS PWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPS EFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV",CYP2C9,(R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC9; P450 PB-1; P450 MP-4/MP-8; S-mephenytoin 4-hydroxylase; P-450MP,490,55629,7.99,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2623,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,1R9O,CYP2C9,CYP2C9,S46963,Chromosome:10,10q24 341,"HLA class II histocompatibility antigen, DP(W4) beta chain",2009-05-11 21:02:55 UTC,2009-06-30 03:51:37 UTC,P04440,"","",">HLA class II histocompatibility antigen, DP(W4) beta chain MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQRFLERYIYNREEFARFDSD VGEFRAVTELGRPAAEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTLQRRVQPRVNVSPSKKGPLQHHN LLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGDVYTCQVEHTSLDSP VTVEWKAQSDSARSKTLTGAGGFVLGLIICGVGIFMHRRSKKVQRGSA",HLA-DPB1,"",258,29160,8.71,">>> Function: Not Available || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response || >>> Component: cell Component: membrane","","PF07654:C1-set PF00969:MHC_II_beta",HGNC:4940,Membrane,,"","",1-29,226-246,Non Essential,"",HLA-DPB1,HLA-DPB1,M62326,"","" 342,"HLA class II histocompatibility antigen, DP alpha chain",2009-05-11 21:03:29 UTC,2009-06-30 03:51:40 UTC,P20036,"","",">HLA class II histocompatibility antigen, DP alpha chain MRPEDRMFHIRAVILRALSLAFLLSLRGAGAIKADHVSTYAAFVQTHRPTGEFMFEFDEDEMFYVDLDKK ETVWHLEEFGQAFSFEAQGGLANIAILNNNLNTLIQRSNHTQATNDPPEVTVFPKEPVELGQPNTLICHI DKFFPPVLNVTWLCNGELVTEGVAESLFLPRTDYSFHKFHYLTFVPSAEDFYDCRVEHWGLDQPLLKHWE AQEPIQMPETTETVLCALGLVLGLVGIIVGTVLIIKSLRSGHDPRAQGTL",HLA-DPA1,HLA-SB alpha chain; MHC class II DP3-alpha; DP(W3); DP(W4),260,29381,4.88,">>> Function: Not Available || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response || >>> Component: cell Component: membrane","","PF07654:C1-set PF00993:MHC_II_alpha",HGNC:4938,Membrane,,"","",1-28,223-245,Non Essential,"",HLA-DPA1,HLA-DPA1,K00514,"","" 343,"HLA class II histocompatibility antigen, DP(W2) beta chain",2009-05-11 21:04:40 UTC,2009-06-30 03:51:43 UTC,P13763,"","",">HLA class II histocompatibility antigen, DP(W2) beta chain MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQRFLERYIYNREEFVRFDSD VGEFRAVTELGRPDEEYWNSQKDILEEERAVPDRMCRHNYELGGPMTLQRRVQPRVNVSPSKKGPLQHHN LLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGDVYTCQVEHTSLDSP VTVEWKAQSDSARSKTLTGAGGFVLGLIICGVGIFMHRRSKKVQRGSA",HLA-DPB1,SB-2-beta,258,29291,7.50,">>> Function: Not Available || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response || >>> Component: cell Component: membrane","","PF07654:C1-set PF00969:MHC_II_beta",HGNC:4940,Membrane,,"","",1-29,226-246,Non Essential,"",HLA-DPB1,HLA-DPB1,X01426,"","" 344,NADH-ubiquinone oxidoreductase chain 2,2009-05-11 23:45:09 UTC,2009-06-30 03:51:47 UTC,P03891,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH-ubiquinone oxidoreductase chain 2 MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMIL LMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPIS IMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYII LTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPT IMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL",MT-ND2,NADH dehydrogenase subunit 2,347,38962,10.30,">>> Function: NADH dehydrogenase (ubiquinone) activity Function: NADH dehydrogenase (ubiquinone) activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity || >>> Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport Process: ATP synthesis coupled electron transport Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: mitochondrial electron transport, NADH to ubiquinone || >>> Component: Not Available",Energy production and conversion,"PF06444:NADH_dehy_S2_C PF00361:Oxidored_q1",HGNC:7456,Mitochondrion inner membrane,,"","",None,"13-33 56-76 96-116 123-143 149-169 178-198 201-221 247-267 274-294 326-346",Non Essential,"",MT-ND2,MT-ND2,AY495302,"Chromosome:MT   
HGNC chromosome: mitochondria","" 345,NADH-ubiquinone oxidoreductase chain 5,2009-05-11 23:45:25 UTC,2009-06-30 03:51:45 UTC,P03915,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH-ubiquinone oxidoreductase chain 5 MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWAT TQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQL FIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSL TPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCL GAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNL NNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTS AYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTA LAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEK LLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT",MT-ND5,NADH dehydrogenase subunit 5,603,67027,9.32,">>> Function: NADH dehydrogenase (ubiquinone) activity Function: NADH dehydrogenase (ubiquinone) activity Function: NADH dehydrogenase (ubiquinone) activity Function: NADH dehydrogenase (ubiquinone) activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport Process: ATP synthesis coupled electron transport || >>> Component: Not Available",Energy production and conversion,"PF06455:NADH5_C PF00361:Oxidored_q1 PF00662:Oxidored_q1_N",HGNC:7461,Mitochondrion inner membrane,,"","",None,"38-58 87-107 122-142 144-160 171-191 211-233 241-261 272-292 301-320 325-347 370-390 407-429 458-478 482-502 582-602",Non Essential,"",MT-ND5,MT-ND5,AY495330,"Chromosome:MT   
HGNC chromosome: mitochondria","" 346,NADH-ubiquinone oxidoreductase chain 6,2009-05-11 23:45:38 UTC,2009-06-30 03:51:35 UTC,P03923,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH-ubiquinone oxidoreductase chain 6 MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYT TAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPI GAGALYDYGRWLVVVTGWTLFVGVYIVIEIARGN",MT-ND6,NADH dehydrogenase subunit 6,174,18622,3.90,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport Process: ATP synthesis coupled electron transport Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: mitochondrial electron transport, NADH to ubiquinone || >>> Component: Not Available","",PF00499:Oxidored_q3,HGNC:7462,Mitochondrion membrane,,"","",None,"1-21 26-46 47-67 86-106 111-131 151-171",Non Essential,"",MT-ND6,MT-ND6,AY495330,"Chromosome:MT   
HGNC chromosome: mitochondria","" 347,NADH-ubiquinone oxidoreductase chain 4,2009-05-11 23:45:52 UTC,2009-06-30 03:51:49 UTC,P03905,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH-ubiquinone oxidoreductase chain 4 MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQINNNLFSCSPTFSSDPLTTPLLMLTT WLLPLTIMASQRHLSSEPLSRKKLYLSMLISLQISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQP ERLNAGTYFLFYTLVGSLPLLIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLY GLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSICLRQT DLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNYERTHSRIMILSQGLQT LLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNITLLLTGLNMLVTALYSLYMFTTTQWGSLT HHINNMKPSFTRENTLMFMHLSPILLLSLNPDIITGFSS",MT-ND4,NADH dehydrogenase subunit 4,459,51582,9.67,">>> Function: NADH dehydrogenase (ubiquinone) activity Function: NADH dehydrogenase (ubiquinone) activity Function: NADH dehydrogenase (ubiquinone) activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity || >>> Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: mitochondrial electron transport, NADH to ubiquinone Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport Process: ATP synthesis coupled electron transport || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: mitochondrion",Energy production and conversion,"PF00361:Oxidored_q1 PF01059:Oxidored_q5_N",HGNC:7459,Mitochondrion membrane,,"","",None,"22-42 60-80 102-122 145-165 196-216 224-244 257-277 284-303 308-330 351-371 391-411",Non Essential,"",MT-ND4,MT-ND4,AY289102,"Chromosome:MT   
HGNC chromosome: mitochondria","" 348,NADH-ubiquinone oxidoreductase chain 4L,2009-05-11 23:46:08 UTC,2009-06-30 03:51:48 UTC,P03901,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH-ubiquinone oxidoreductase chain 4L MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVPIAMLVFAACE AAVGLALLVSISNTYGLDYVHNLNLLQC",MT-ND4L,NADH dehydrogenase subunit 4L,98,10741,6.20,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport Process: ATP synthesis coupled electron transport Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: mitochondrial electron transport, NADH to ubiquinone || >>> Component: Not Available","",PF00420:Oxidored_q2,HGNC:7460,Mitochondrion membrane,,"","",None,"1-21 29-49 58-78",Non Essential,"",MT-ND4L,MT-ND4L,AY495330,"Chromosome:MT   
HGNC chromosome: mitochondria","" 349,NADH-ubiquinone oxidoreductase chain 3,2009-05-11 23:46:22 UTC,2009-06-30 03:51:35 UTC,P03897,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH-ubiquinone oxidoreductase chain 3 MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIA LLLPLPWALQTTNLPLMVMSSLLLIIILALSLAYEWLQKGLDWTE",MT-ND3,NADH dehydrogenase subunit 3,115,13186,4.08,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport Process: ATP synthesis coupled electron transport Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: mitochondrial electron transport, NADH to ubiquinone || >>> Component: Not Available",Energy production and conversion,PF00507:Oxidored_q4,HGNC:7458,Mitochondrion membrane,,"","",None,"3-23 55-75 84-104",Non Essential,"",MT-ND3,MT-ND3,AY495330,"Chromosome:MT   
HGNC chromosome: mitochondria","" 350,"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial",2009-05-11 23:46:56 UTC,2009-06-30 03:51:34 UTC,P49821,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial MLATRRLLGWSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGSLSRGDWYKTKEILL KGPDWILGEIKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREILRHDPHKLLE GCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEET ALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISG HVNHPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLG TAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIE GHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQQHQARQAAS",NDUFV1,NADH-ubiquinone oxidoreductase 51 kDa subunit; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1,464,50818,8.29,">>> Function: cofactor binding Function: coenzyme binding Function: NAD binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on NADH or NADPH Function: nucleotide binding Function: FMN binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport Process: ATP synthesis coupled electron transport Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: mitochondrial electron transport, NADH to ubiquinone || >>> Component: Not Available",Energy production and conversion,PF01512:Complex1_51K,HGNC:7716,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",NDUFV1,NDUFV1,S67973,Chromosome:11,11q13 351,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial",2009-05-11 23:47:12 UTC,2009-06-30 03:51:46 UTC,O75306,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial MAALRALCGFRGVAAQVLRPGAGVRLPIQPSRGVRQWQPDVEWAQQFGGAVMYPSKETAHWKPPPWNDVD PPKDTIVKNITLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLD YVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEITRLLNHIMAVTTHALDLGAMTPFFWLFEEREKM FEFYERVSGARMHAAYIRPGGVHQDLPLGLMDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVVTA EEALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPVGSRGDCYDRYLCRVEEMRQSLRIIAQCLNK MPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPY RCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR",NDUFS2,NADH-ubiquinone oxidoreductase 49 kDa subunit; Complex I-49kD; CI-49kD,463,52546,7.61,">>> Function: transporter activity Function: electron transporter activity Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on NADH or NADPH || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,PF00346:Complex1_49kDa,HGNC:7708,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",NDUFS2,NDUFS2,BC008868,"","" 352,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial",2009-05-11 23:47:29 UTC,2009-06-30 03:51:39 UTC,O75251,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial MAVLSAPGLRGFRILGLRSSVGPAVQARGVHQSVATDGPSSTQPALPKARAVAPKPSSRGEYVVAKLDDL VNWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQSDVMIVAGTLTNKMAPALRKVYDQ MPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYIPGCPPTAEALLYGILQLQRKIKRERRLQIW YRR",NDUFS7,NADH-ubiquinone oxidoreductase 20 kDa subunit; Complex I-20kD; CI-20kD; PSST subunit,213,23564,10.36,">>> Function: NADH dehydrogenase (ubiquinone) activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity || >>> Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport Process: ATP synthesis coupled electron transport Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: mitochondrial electron transport, NADH to ubiquinone || >>> Component: Not Available",Energy production and conversion,PF01058:Oxidored_q6,HGNC:7714,Mitochondrion,,"","",None,None,Non Essential,"",NDUFS7,NDUFS7,BC111517,Chromosome:19,19p13.3 353,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial",2009-05-11 23:47:44 UTC,2009-06-30 03:51:42 UTC,O00217,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone,"",">NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLLWTELFRGLGM TLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRT TRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR",NDUFS8,NADH-ubiquinone oxidoreductase 23 kDa subunit; Complex I-23kD; CI-23kD; TYKY subunit,210,23705,6.27,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on NADH or NADPH Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: transporter activity Function: electron transporter activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,PF00037:Fer4,HGNC:7715,Mitochondrion (Probable),,"","",None,None,Non Essential,"",NDUFS8,NDUFS8,BC119754,Chromosome:11,11q13 354,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial",2009-05-11 23:48:06 UTC,2009-06-30 03:51:42 UTC,O75489,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial MAAAAVARLWWRGILGASALTRGTGRPSVLLLPVRRESAGADTRPTVRPRNDVAHKQLSAFGEYVAEILP KYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVPTRQNRFEIVYNLLSLRFNSR IRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVEL RYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPVYRQPPESLKLEAGDKKPDAK",NDUFS3,NADH-ubiquinone oxidoreductase 30 kDa subunit; Complex I-30kD; CI-30kD,264,30242,7.62,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on NADH or NADPH || >>> Process: ATP synthesis coupled electron transport Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: mitochondrial electron transport, NADH to ubiquinone Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,PF00329:Complex1_30kDa,HGNC:7710,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",NDUFS3,NDUFS3,BC000617,Chromosome:11,11p11.11 355,"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial",2009-05-11 23:48:53 UTC,2009-06-30 03:51:39 UTC,P19404,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial MFFSAALRARAAGLTAHWGRHVRNLHKTVMQNGAGGALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNY PEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPC MLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTAKDIEEIIDELKA GKIPKPGPRSGRFSCEPAGGLTSLTEPPKGPGFGVQAGL",NDUFV2,NADH-ubiquinone oxidoreductase 24 kDa subunit,249,27392,8.21,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport Process: ATP synthesis coupled electron transport Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: mitochondrial electron transport, NADH to ubiquinone || >>> Component: Not Available",Energy production and conversion,PF01257:Complex1_24kDa,HGNC:7717,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",NDUFV2,NDUFV2,BC017487,Chromosome:18,18p11.31-p11.2 356,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial",2009-05-11 23:49:29 UTC,2009-06-30 03:51:34 UTC,O43181,"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone","",">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial MAAVSMSVVLRQTLWRRRAVAVAALSVSRVPTRSLRTSTWRLAQDQTQDTQLITVDEKLDITTLTGVPEE HIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADPLSNMVLTFSTKEDAVSFAEK NGWSYDIEERKVPKPKSKSYGANFSWNKRTRVSTK",NDUFS4,NADH-ubiquinone oxidoreductase 18 kDa subunit; Complex I-18 kDa; CI-18 kDa; Complex I-AQDQ; CI-AQDQ,175,20108,11.02,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on NADH or NADPH || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF04800:ETC_C1_NDUFA4,HGNC:7711,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",NDUFS4,NDUFS4,BC005270,"","" 357,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial",2009-05-11 23:49:46 UTC,2009-06-30 03:51:38 UTC,O75380,"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone","",">NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial MAAAMTFCRLLNRCGEAARSLPLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVNENFAID LIAEQPVSEVETRVIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFRQHHH",NDUFS6,NADH-ubiquinone oxidoreductase 13 kDa-A subunit; Complex I-13kD-A; CI-13kD-A,124,13712,8.38,"","","",HGNC:7713,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",NDUFS6,NDUFS6,BC046155,"","" 358,NADH dehydrogenase [ubiquinone] iron-sulfur protein 5,2009-05-11 23:50:08 UTC,2009-06-30 03:51:41 UTC,O43920,"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone","",">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 MPFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQ KTMRRAGTIRKQRDKLIKEGKYTPPPHHIGKGEPRP",NDUFS5,NADH-ubiquinone oxidoreductase 15 kDa subunit; Complex I-15 kDa; CI-15 kDa,106,12518,9.54,"","","",HGNC:7712,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",NDUFS5,NDUFS5,BC001884,"","" 359,"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial",2009-05-11 23:50:24 UTC,2009-06-30 03:51:34 UTC,P56181,"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone","",">NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKKPAPVPAEPFDNTT YKNLQHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH",NDUFV3,NADH-ubiquinone oxidoreductase 9 kDa subunit; Complex I-9kD; CI-9kD; Renal carcinoma antigen NY-REN-4,108,11941,10.30,"","","",HGNC:7719,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",NDUFV3,NDUFV3,BC054016,Chromosome:21,21q22.3 360,"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial",2009-05-11 23:53:11 UTC,2009-06-30 03:51:45 UTC,P28331,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized,"",">NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial MLRIPVRKALVGLSKSPKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLS VAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQ DQSMMFGNDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYI EKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHED INEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEA LVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRK SWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAIL AAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDL PKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIA GMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSI SRASQTMAKCVKAVTEGAQAVEEPSIC",NDUFS1,Complex I-75kD; CI-75kD,727,79468,6.11,">>> Function: oxidoreductase activity, acting on NADH or NADPH Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: NADH dehydrogenase (ubiquinone) activity Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: transporter activity Function: electron transporter activity || >>> Process: ATP synthesis coupled electron transport Process: ATP synthesis coupled electron transport (sensu Eukaryota) Process: mitochondrial electron transport, NADH to ubiquinone Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,"PF09326:DUF1982 PF00111:Fer2 PF00384:Molybdopterin",HGNC:7707,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",NDUFS1,NDUFS1,BC030833,"","" 361,Sulfotransferase 1A1,2009-05-12 19:36:43 UTC,2009-06-30 03:51:36 UTC,P50225,"Catalyzes the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk","",">Sulfotransferase 1A1 MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKC HRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYY HFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEF VGRSLPEETVDFMVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADY AEKMAGCSLSFRSEL",SULT1A1,Aryl sulfotransferase 1; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; P-PST 1; Thermostable phenol sulfotransferase; Ts-PST; HAST1/HAST2; ST1A3,295,34198,6.61,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring sulfur-containing groups Function: sulfotransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00685:Sulfotransfer_1,HGNC:11453,Cytoplasm,,"","",None,None,Non Essential,1LS6,SULT1A1,SULT1A1,L15346,Chromosome:16,16p12.1 362,Sulfotransferase 1A3/1A4,2009-05-12 19:37:02 UTC,2009-06-30 03:51:42 UTC,P50224,"Catalyzes the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs","",">Sulfotransferase 1A3/1A4 MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDMIYQGGDLEKC NRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYY HFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEF VGRSLPEETMDFMVQHTSFKEMKKNPMTNYTTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADY AEKMAGCSLSFRSEL",SULT1A3,"Monoamine-sulfating phenol sulfotransferase; Aryl sulfotransferase 1A3/1A4; Sulfotransferase, monoamine-preferring; M-PST; Thermolabile phenol sulfotransferase; TL-PST; Placental estrogen sulfotransferase; Catecholamine-sulfating phenol sulfotransferase; HAST3",295,34197,5.88,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring sulfur-containing groups Function: sulfotransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00685:Sulfotransfer_1,HGNC:11455,Cytoplasm,,"","",None,None,Non Essential,1CJM,SULT1A3,SULT1A3,U08099,Chromosome:16,16p11.2 363,Sulfotransferase 1A2,2009-05-12 19:37:12 UTC,2009-06-30 03:51:34 UTC,P50226,"Catalyzes the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk","",">Sulfotransferase 1A2 MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKC HRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYY HFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEF VGRSLPEETVDLMVEHTSFKEMKKTPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADY AEKMAGCSLSFRSEL",SULT1A2,Aryl sulfotransferase 2; Phenol sulfotransferase 2; Phenol-sulfating phenol sulfotransferase 2; P-PST 2; ST1A2,295,34286,7.32,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring sulfur-containing groups Function: sulfotransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00685:Sulfotransfer_1,HGNC:11454,Cytoplasm,,"","",None,None,Non Essential,1LS6,SULT1A2,SULT1A2,U33886,Chromosome:16,16p12.1 364,Sulfotransferase family cytosolic 1B member 1,2009-05-12 19:37:50 UTC,2009-06-30 03:51:44 UTC,O43704,"Catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'- diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine","",">Sulfotransferase family cytosolic 1B member 1 MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDMILNDGDIEKC KRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLPKSFWENNCKMIYLARNAKDVSVSY YHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNWWKKKEEHPILFLYYEDMKENPKEEIKKIIR FLEKNLNDEILDRIIHHTSFEVMKDNPLVNYTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAI YETEMSKTALQFRTEI",SULT1B1,Sulfotransferase 1B2; Thyroid hormone sulfotransferase,296,34900,7.07,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring sulfur-containing groups Function: sulfotransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00685:Sulfotransfer_1,HGNC:17845,Cytoplasm (By similarity),,"","",None,None,Non Essential,1XV1,SULT1B1,SULT1B1,AF184894,"","" 365,Transthyretin,2009-05-12 20:03:36 UTC,2009-06-30 03:51:42 UTC,P02766,Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain,"",">Transthyretin MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTS ESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTA VVTNPKE",TTR,Prealbumin; TBPA; TTR; ATTR,147,15887,5.58,">>> Function: binding Function: steroid binding Function: transporter activity Function: carrier activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available","",PF00576:Transthyretin,HGNC:12405,Secreted,,"","",1-20,None,Non Essential,1KED,TTR,TTR,M63285,Chromosome:18,18q12.1 366,Thyroxine-binding globulin,2009-05-12 20:05:27 UTC,2009-06-30 03:51:35 UTC,P05543,Major thyroid hormone transport protein in serum,"",">Thyroxine-binding globulin MSPFLYLVLLVLGLHATIHCASPEGKVTACHSSQPNATLYKMSSINADFAFNLYRRFTVETPDKNIFFSP VSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHL KPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQW ANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESV EAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAA HKAVLHIGEKGTEAAAVPEVELSDQPENTFLHPIIQIDRSFMLLILERSTRSILFLGKVVNPTEA",SERPINA7,T4-binding globulin; Serpin A7,415,46325,6.27,">>> Function: enzyme regulator activity Function: enzyme inhibitor activity Function: protease inhibitor activity Function: endopeptidase inhibitor activity Function: serine-type endopeptidase inhibitor activity || >>> Process: Not Available || >>> Component: Not Available","",PF00079:Serpin,HGNC:11583,Secreted,,"","",1-20,None,Non Essential,"",SERPINA7,SERPINA7,BC020747,"","" 367,Choline O-acetyltransferase,2009-05-12 20:10:42 UTC,2009-06-30 03:51:39 UTC,P28329,Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses,"",">Choline O-acetyltransferase MGLRTAKKRGLGGGGKWKREEGGGTRGRREVRPACFLQSGGRGDPGDVGGPAGNPGCSPHPRAATRPPPL PAHTPAHTPEWCGAASAEAAEPRRAGPHLCIPAPGLTKTPILEKVPRKMAAKTPSSEESGLPKLPVPPLQ QTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLAL PVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSY RLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPI GLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANR WYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQSSRKLIRADSVSELPAPRRLRWKCSPE IQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIR RFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALREL ARAMCKELPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCK ETSSSKFAKAVEESLIDMRDLCSLLPPTESKPLATKEKATRPSQGHQP",CHAT,Choline acetylase; CHOACTase; ChAT,748,82569,8.69,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00755:Carn_acyltransf,HGNC:1912,"",,"","",None,None,Non Essential,"",CHAT,CHAT,X56879,Chromosome:10,10q11.2 368,Carnitine O-acetyltransferase,2009-05-12 20:10:53 UTC,2009-06-30 03:51:48 UTC,P43155,Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria,"",">Carnitine O-acetyltransferase MLAFAARTVVKPLGFLKPFSLMKASSRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLV DEFQASGGVGERLQKGLERRARKTENWLSEWWLKTAYLQYRQPVVIYSSPGVMLPKQDFVDLQGQLRFAA KLIEGVLDFKVMIDNETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDTVSNFSKTKKPPTHITVVHNYQ FFELDVYHSDGTPLTADQIFVQLEKIWNSSLQTNKEPVGILTSNHRNSWAKAYNTLIKDKVNRDSVRSIQ KSIFTVCLDATMPRVSEDVYRSHVAGQMLHGGGSRLNSGNRWFDKTLQFIVAEDGSCGLVYEHAAAEGPP IVTLLDYVIEYTKKPELVRSPLVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKD FPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAMDDSSVTEH QKVELLRKAVQAHRGYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFHLSTSQVPAKT DCVMFFGPVVPDGYGVCYNPMEAHINFSLSAYNSCAETNAARLAHYLEKALLDMRALLQSHPRAKL",CRAT,Carnitine acetylase; Carnitine acetyltransferase; CrAT; CAT,626,70858,8.63,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00755:Carn_acyltransf,HGNC:2342,Endoplasmic reticulum (Potential). Peroxisome (Potential). Mitochondrion inner membrane,,"","",None,None,Non Essential,1S5O,CRAT,CRAT,X78706,"","" 369,Lysophosphatidylcholine acyltransferase 2,2009-05-12 20:11:03 UTC,2009-06-30 03:51:44 UTC,Q7L5N7,Probable acetyltransferase (By similarity),"",">Lysophosphatidylcholine acyltransferase 2 MSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVLLGIILLPIRV LLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFFSMGFIVAVKGKIASPLEAPV FVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGG EWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTK VEVEFMPVQVPNDEEKNDPVLFANKVRNLMAEALGIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKIS RKLKLDWDGVRKHLDEYASIASSSKGGRIGIEEFAKYLKLPVSDVLRQLFALFDRNHDGSIDFREYVIGL AVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDSISYEEFKSFA LKHPEYAKIFTTYLDLQTCHVFSLPKEVQTTPSTASNKVSPEKHEESTSDKKDD",LPCAT2,Acyltransferase-like 1,544,60208,6.51,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF01553:Acyltransferase PF00036:efhand",HGNC:26032,Membrane,,"","",None,58-78,Non Essential,"",LPCAT2,LPCAT2,BC002472,Chromosome:16,16q12.2 370,1-acylglycerophosphocholine O-acyltransferase 1,2009-05-12 20:11:18 UTC,2009-06-30 03:51:37 UTC,Q8NF37,"Acetyltransferase which mediates the conversion of 1- acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Has a calcium-independent activity. Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1- palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant thereby playing a pivotal role in respiratory physiology (By similarity)","",">1-acylglycerophosphocholine O-acyltransferase 1 MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKAQVALMTLTLFPVRLLVAAAMMLLAWP LALVASLGSAEKEPEQPPALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGRQALPTEAAILTLAPHSSYFD AIPVTMTMSSIVMKAESRDIPIWGTLIQYIRPVFVSRSDQDSRRKTVEEIKRRAQSNGKWPQIMIFPEGT CTNRTCLITFKPGAFIPGAPVQPVVLRYPNKLDTITWTWQGPGALEILWLTLCQFHNQVEIEFLPVYSPS EEEKRNPALYASNVRRVMAEALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPEKLEK DLDRYSERARMKGGEKIGIAEFAASLEVPVSDLLEDMFSLFDESGSGEVDLRECVVALSVVCRPARTLDT IQLAFKMYGAQEDGSVGEGDLSCILKTALGVAELTVTDLFRAIDQEEKGKITFADFHRFAEMYPAFAEEY LYPDQTHFESCAETSPAPIPNGFCADFSPENSDAGRKPVRKKLD",LPCAT1,Lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1; Lysophosphatidylcholine acyltransferase 1; Acyltransferase-like 2; Phosphonoformate immuno-associated protein 3,534,59152,5.82,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF01553:Acyltransferase PF00036:efhand",HGNC:25718,Endoplasmic reticulum membrane,,"","",None,58-78,Non Essential,"",LPCAT1,LPCAT1,AL831864,"","" 371,Potassium-transporting ATPase alpha chain 1,2009-05-12 20:45:10 UTC,2009-06-30 03:51:38 UTC,P20648,Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach,"",">Potassium-transporting ATPase alpha chain 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSA TKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDN LYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRV PADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGR IASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLAT VTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQ TFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCE IPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLG ERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGD HPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMV FARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIV TGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAES DIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQ DSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFL CYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY",ATP4A,Proton pump; Gastric H(+)/K(+) ATPase subunit alpha,1035,114120,5.54,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: monovalent inorganic cation transporter activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: monovalent inorganic cation transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF09040:H-K_ATPase_N PF00702:Hydrolase",HGNC:819,Membrane,,"","",None,"99-119 143-163 300-319 332-349 784-803 814-834 855-877 930-949 964-982 998-1018",Non Essential,"",ATP4A,ATP4A,M27575,Chromosome:19,19q13.1 372,Potassium-transporting ATPase alpha chain 2,2009-05-12 20:46:31 UTC,2009-06-30 03:51:38 UTC,P54707,Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues,"",">Potassium-transporting ATPase alpha chain 2 MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKY GTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSA SLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKG GDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRT IIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEG LLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSED HSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNR KVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMEL GGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIM VTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANY QEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNF ASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYE KAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYV NDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIII GLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY",ATP12A,Proton pump; Non-gastric H(+)/K(+) ATPase subunit alpha,1039,115512,6.52,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: monovalent inorganic cation transporter activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: monovalent inorganic cation transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:13816,Membrane,,"","",None,"103-123 147-167 304-323 336-353 788-807 818-838 859-881 934-953 968-986 1002-1022",Non Essential,"",ATP12A,ATP12A,M27574,Chromosome:13,13q12.12|13q12.1-q12.3 373,Potassium-transporting ATPase subunit beta,2009-05-12 20:47:02 UTC,2009-06-30 03:51:45 UTC,P51164,"","",">Potassium-transporting ATPase subunit beta MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQTVDPYT PDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQEDSINCTSEQYFFQE SFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKMNRIVKFLPSNGSAPRVDCAFLDQPREL GQPLQVKYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYE GKVEFKLKIEK",ATP4B,Proton pump beta chain; Gastric H(+)/K(+) ATPase subunit beta,291,33367,7.37,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: sodium:potassium-exchanging ATPase activity || >>> Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF00287:Na_K-ATPase,HGNC:820,Membrane,,"","",None,37-57,Non Essential,"",ATP4B,ATP4B,AB008783,Chromosome:13,13q34 374,X/potassium-transporting ATPase subunit beta-m,2009-05-12 20:48:19 UTC,2009-06-30 03:51:34 UTC,Q9UN42,This is the non-catalytic component of a yet unknown sodium or proton exchange ATPase,"",">X/potassium-transporting ATPase subunit beta-m MRRQLRSRRAPSFPYSYRYRLDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEE EEGQGQPTGNAWWQKLQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFYASLAAVITLCMYTLFLTISP YIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQD GNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIR SISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVI FTLNIET",ATP1B4,"X,K-ATPase subunit beta-m",357,41598,4.40,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: sodium:potassium-exchanging ATPase activity || >>> Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane",Transcription,PF00287:Na_K-ATPase,HGNC:808,Membrane,,"","",None,111-131,Non Essential,"",ATP1B4,ATP1B4,BC117227,"","" 375,Cytochrome P450 2E1,2009-05-13 04:53:21 UTC,2009-06-30 03:51:40 UTC,P05181,"Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms","",">Cytochrome P450 2E1 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTL YVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLL STPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSA ERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVI PRS",CYP2E1,CYPIIE1; P450-J,493,56850,8.22,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2631,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP2E1,CYP2E1,D50111,Chromosome:10,10q24.3-qter 376,"5-aminolevulinate synthase, nonspecific, mitochondrial",2009-05-13 15:09:53 UTC,2009-06-30 03:51:35 UTC,P13196,Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2),"",">5-aminolevulinate synthase, nonspecific, mitochondrial MESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKT AKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAV RKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPERVSHLLQDNLPKSVSTFQYDRFFEKKIDEK KNDHTYRVFKTVNRRAHIFPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGT RNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSR VPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYG ARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVR ILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINY PTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLELKPHSSAECNFCRRPLHFEVMSEREKSYFS GLSKLVSAQA",ALAS1,5-aminolevulinic acid synthase; Delta-aminolevulinate synthase; Delta-ALA synthetase; ALAS-H,640,70582,8.57,">>> Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity Function: N-acyltransferase activity Function: N-succinyltransferase activity Function: 5-aminolevulinate synthase activity || >>> Process: biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis Process: heme biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00155:Aminotran_1_2,HGNC:396,Mitochondrion matrix,,"","",None,None,Non Essential,"",ALAS1,ALAS1,BC011798,"","" 377,"Actin, aortic smooth muscle",2009-05-13 15:15:07 UTC,2009-06-30 03:51:44 UTC,P62736,Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells,"",">Actin, aortic smooth muscle MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLK YPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQA VLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETT YNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS LSTFQQMWISKQEYDEAGPSIVHRKCF",ACTA2,Alpha-actin-2; Cell growth-inhibiting gene 46 protein,377,42009,5.05,">>> Function: binding Function: protein binding Function: structural molecule activity Function: structural constituent of cytoskeleton Function: motor activity || >>> Process: Not Available || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: actin cytoskeleton Component: actin filament",Cytoskeleton,PF00022:Actin,HGNC:130,"Cytoplasm, cytoskeleton",,"","",None,None,Non Essential,1IJJ,ACTA2,ACTA2,M33216,Chromosome:10,10q23.3 378,"Actin, alpha cardiac muscle 1",2009-05-13 15:15:19 UTC,2009-06-30 03:51:40 UTC,P68032,Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells,"",">Actin, alpha cardiac muscle 1 MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLK YPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQA VLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETT YNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS LSTFQQMWISKQEYDEAGPSIVHRKCF",ACTC1,Alpha-cardiac actin,377,42019,5.05,">>> Function: binding Function: protein binding Function: structural molecule activity Function: structural constituent of cytoskeleton Function: motor activity || >>> Process: Not Available || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: actin cytoskeleton Component: actin filament",Cytoskeleton,PF00022:Actin,HGNC:143,"Cytoplasm, cytoskeleton",,"","",None,None,Non Essential,1IJJ,ACTC1,ACTC1,BC009978,Chromosome:15,15q11-q14 379,"Actin, alpha skeletal muscle",2009-05-13 15:15:41 UTC,2009-06-30 03:51:37 UTC,P68133,Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells,"",">Actin, alpha skeletal muscle MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLK YPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQA VLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETT YNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS LSTFQQMWITKQEYDEAGPSIVHRKCF",ACTA1,Alpha-actin-1,377,42052,5.05,">>> Function: binding Function: protein binding Function: structural molecule activity Function: structural constituent of cytoskeleton Function: motor activity || >>> Process: Not Available || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: actin cytoskeleton Component: actin filament",Cytoskeleton,PF00022:Actin,HGNC:129,"Cytoplasm, cytoskeleton",,"","",None,None,Non Essential,1IJJ,ACTA1,ACTA1,BC012597,"","" 380,"Actin, gamma-enteric smooth muscle",2009-05-13 15:15:53 UTC,2009-06-30 03:51:47 UTC,P63267,Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells,"",">Actin, gamma-enteric smooth muscle MCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKY PIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAV LSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIV RDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTY NSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASL STFQQMWISKPEYDEAGPSIVHRKCF",ACTG2,Smooth muscle gamma-actin; Gamma-2-actin; Alpha-actin-3,376,41877,5.16,">>> Function: binding Function: protein binding Function: structural molecule activity Function: structural constituent of cytoskeleton Function: motor activity || >>> Process: Not Available || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: actin cytoskeleton Component: actin filament",Cytoskeleton,PF00022:Actin,HGNC:145,"Cytoplasm, cytoskeleton",,"","",None,None,Non Essential,1IJJ,ACTG2,ACTG2,BC094877,"","" 381,Aquaporin-12B,2009-05-13 15:51:02 UTC,2009-06-30 03:51:49 UTC,A6NM10,Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity),"",">Aquaporin-12B MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLLLTLLFLLFLA HGVTLDGASANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQAACTLTRLCWAWELSDLHLLQSLMAQSCS SALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFA CSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSS VREPGRSGVEGPHSS",AQP12B,AQP-12B,295,31476,8.09,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane","","",HGNC:6096,Membrane,,"","",None,"1-21 55-75 100-126 146-166 179-199 216-236",Non Essential,"",AQP12B,AQP12B,BC139748,"","" 382,Lens fiber major intrinsic protein,2009-05-13 15:51:35 UTC,2009-06-30 03:51:47 UTC,P30301,Water channel. May be responsible for regulating the osmolarity of the lens,"",">Lens fiber major intrinsic protein MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVGHISGAHVNPA VTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQ FVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGMNPARSFAPAILTGNFTNHWVYWVGPII GGGLGSLLYDFLLFPRLKSISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL",MIP,Aquaporin-0; MIP26; MP26,263,28122,8.67,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:7103,Cell membrane,,"","",None,"17-37 41-60 86-107 124-149 157-178 197-219",Non Essential,1YMG,MIP,MIP,BC117474,Chromosome:12,12q13 383,Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform,2009-05-13 16:06:40 UTC,2009-06-30 03:51:40 UTC,Q08209,"Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1","",">Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGAS ILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILY PKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLD DIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRA HEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVF TWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAM PSDANLNSINKALTSETNGTDSNGSNSSNIQ",PPP3CA,Calmodulin-dependent calcineurin A subunit alpha isoform; CAM-PRP catalytic subunit,521,58688,5.66,">>> Function: catalytic activity Function: hydrolase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00149:Metallophos,HGNC:9314,Nucleus (By similarity),,"","",None,None,Non Essential,1AUI,PPP3CA,PPP3CA,BC025714,"","" 384,Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform,2009-05-13 16:07:01 UTC,2009-06-30 03:51:44 UTC,P16298,"Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin","",">Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIA LRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVL YLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGG LSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQN NNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPY WLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFS VLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINE RMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ",PPP3CB,Calmodulin-dependent calcineurin A subunit beta isoform; CAM-PRP catalytic subunit,524,59025,5.75,">>> Function: catalytic activity Function: hydrolase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00149:Metallophos,HGNC:9315,Cytoplasmic,,"","",None,None,Non Essential,"",PPP3CB,PPP3CB,CH471083,Chromosome:10,10q21-q22 385,Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform,2009-05-13 16:07:46 UTC,2009-06-30 03:51:48 UTC,P48454,"Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin","",">Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQ EKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTL FLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRK LDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQ DAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSL PFVGEKVTEMLVNVLNICSDDELISDDEAEGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGL TPTGTLPLGVLSGGKQTIETAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSIHAGGPMKSVTSAHSHA AHRSDQGKKAHS",PPP3CC,"Calmodulin-dependent calcineurin A subunit gamma isoform; Calcineurin, testis-specific catalytic subunit; CAM-PRP catalytic subunit",502,57074,7.23,">>> Function: catalytic activity Function: hydrolase activity || >>> Process: Not Available || >>> Component: Not Available",Signal transduction mechanisms,PF00149:Metallophos,HGNC:9316,Cytoplasmic,,REACT_578-Apoptosis;,"",None,None,Non Essential,"",PPP3CC,PPP3CC,CH471080,"","" 386,Carbonic anhydrase 2,2009-05-13 16:19:57 UTC,2009-06-30 03:51:44 UTC,P00918,Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 2 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEF DDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGL AVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIV LKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK",CA2,Carbonic anhydrase II; CA-II; Carbonate dehydratase II; Carbonic anhydrase C; CAC,260,29246,7.47,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1373,Cytoplasm,,"","",None,None,Non Essential,1T9N,CA2,CA2,M36532,"","" 387,Carbonic anhydrase 4,2009-05-13 16:20:08 UTC,2009-06-30 03:51:34 UTC,P22748,Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4,"",">Carbonic anhydrase 4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRF FFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMH IVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPK EEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRT VIKSGAPGRPLPWALPALLGPMLACLLAGFLR",CA4,Carbonic anhydrase IV; CA-IV; Carbonate dehydratase IV,312,35033,7.94,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1375,Cell membrane,,"","",1-18,None,Non Essential,1ZNC,CA4,CA4,BC074768,Chromosome:17,17q23 388,Copper-transporting ATPase 2,2009-05-13 16:40:52 UTC,2009-06-30 03:51:45 UTC,P35670,"Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile","",">Copper-transporting ATPase 2 MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATSTVRILGMTCQ SCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEASIAEGKAASWPSRSLPA QEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAI KSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIG QLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPP RNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDM GFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKC FLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYA GSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHAS LAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFF ILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPML FVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFP VDGKVLEGNTMADESLITGEAMPVTKKPGSTVIARSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSK APIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQKYFPNPNKHISQTEVIIRFAFQTSITVLC IACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVAT LPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPL SAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCG MIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALI YNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQV SVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI",ATP7B,Copper pump 2; Wilson disease-associated protein; Contains: RecName: WND/140 kDa,1465,157336,6.74,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: cation binding Function: transition metal ion binding Function: copper ion binding Function: metal ion transporter activity Function: ion binding Function: metal ion binding Function: di-, tri-valent inorganic cation transporter activity Function: copper ion transporter activity Function: copper-exporting ATPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: di-, tri-valent inorganic cation transport Process: transition metal ion transport Process: copper ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: metal ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Inorganic ion transport and metabolism,"PF00122:E1-E2_ATPase PF00403:HMA PF00702:Hydrolase",HGNC:870,WND/140 kDa:Mitochondrion,,"","",None,"654-675 698-717 725-745 765-785 920-942 973-994 1323-1340 1352-1371",Non Essential,"",ATP7B,ATP7B,S77450,Chromosome:13,13q14.3 389,"Cytochrome c oxidase subunit 7A3, mitochondrial",2009-05-13 17:26:40 UTC,2009-06-30 03:51:42 UTC,O60397,"","",">Cytochrome c oxidase subunit 7A3, mitochondrial MLWNLLALHQIGQRTISTASHRHFKNKVPEKQKLFQEDDGIPLYLKGGIADALLHRATMILTVGGTAYAI YQLAVASFPNKGVTSIIPAITWFTFIQLSMDQKSDK",COX7AP2,Cytochrome c oxidase subunit VIIa 3,106,11841,10.14,">>> Function: transporter activity Function: electron transporter activity Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02238:COX7a,HGNC:2290,Mitochondrion inner membrane (By similarity),,"","",None,None,Non Essential,"",COX7AP2,COX7AP2,AC004544,"","" 390,Probable glutathione peroxidase 8,2009-05-13 18:14:51 UTC,2009-06-30 03:51:49 UTC,Q8TED1 ,2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O,"",">Probable glutathione peroxidase 8 MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKVS LVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLAFPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKI KILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKFWRPEEPIEVIRPDIAALVRQVIIKKKEDL",GPX8,"",209,23909,9.93,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:33100,Membrane,,"","",None,18-40,Non Essential,"",GPX8,GPX8,BC029424,"","" 391,Gamma-aminobutyric acid receptor subunit epsilon,2009-05-13 18:34:23 UTC,2009-06-30 03:51:49 UTC,P78334,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit epsilon MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETETGSRVGKLPE ASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERLCYNDTFESL VLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCP LSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYV AFQNYVPSSVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVF CFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFPV TFFFFNVLYWLVCLNL",GABRE,GABA(A) receptor subunit epsilon,506,57972,8.09,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4085,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-22,"254-274 281-301 344-364 486-506",Non Essential,"",GABRE,GABRE,U92283,"","" 392,Ig delta chain C region,2009-05-13 19:58:09 UTC,2009-06-30 03:51:38 UTC,P01880,"","",">Ig delta chain C region APTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQL STPLQQWRQGEYKCVVQHTASKSKKEIFRWPESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGE EKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKV PTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLL ASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQP ATYTCVVSHEDSRTLLNASRSLEVSYVTDHGPMK",IGHD,"",384,42254,8.02,"","","",HGNC:5480,Isoform 2:Cell membrane,,"","",None,None,Non Essential,"",IGHD,IGHD,K02880,Chromosome:14,14q32.33 393,Ig epsilon chain C region,2009-05-13 19:58:19 UTC,2009-06-30 03:51:35 UTC,P01854,"","",">Ig epsilon chain C region ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATIS LLTVSGAWAKQMFTCRVAHTPSSTDWVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGY TPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCA DSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTV TSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNF MPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQR AVSVNPGK",IGHE,"",428,47019,8.13,"","","PF07654:C1-set PF00047:ig",HGNC:5522,"",,"","",None,None,Non Essential,1O0V,IGHE,IGHE,J00222,Chromosome:14,14q32.33 394,Ig alpha-2 chain C region,2009-05-13 19:58:40 UTC,2009-06-30 03:51:49 UTC,P01877,Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system,"",">Ig alpha-2 chain C region ASPTSPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQL TLPATQCPDGKSVTCHVKHYTNPSQDVTVPCPVPPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLR DASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSG NTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFA VTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY",IGHA2,"",340,36508,6.02,"","",PF07654:C1-set,HGNC:5479,"",,"","",None,None,Non Essential,1R70,IGHA2,IGHA2,"",Chromosome:14,14q32.33 395,Sperm protamine-P1,2009-05-13 21:24:26 UTC,2009-06-30 03:51:49 UTC,P04553,"Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex","",">Sperm protamine-P1 MARYRCCRSQSRSRYYRQRQRSRRRRRRSCQTRRRAMRCCRPRYRPRCRRH",PRM1,Cysteine-rich protamine,51,6823,12.57,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: reproduction Process: sexual reproduction Process: gametogenesis Process: male gamete generation Process: spermatogenesis Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00260:Protamine_P1,HGNC:9447,Nucleus,,"","",None,None,Non Essential,"",PRM1,PRM1,BC003673,"","" 396,Protamine-3,2009-05-13 21:24:41 UTC,2009-06-30 03:51:40 UTC,Q9NNZ6,"Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity)","",">Protamine-3 MGSRCAKLNTGQSPGHSPGHSTGHGRGHESSMKKLMACVSQDNFSLSSAGEEEEEEEEEGEEEEKEELPV QGKLLLLEPERQEEGQKDNAEAQQSPEPKQTPS",PRM3,Sperm protamine P3,103,11232,4.24,"","","",HGNC:13732,Nucleus (By similarity),,"","",None,None,Non Essential,"",PRM3,PRM3,Z46940,Chromosome:16,16p13.3 397,Retinoic acid receptor alpha,2009-05-13 21:39:56 UTC,2009-06-30 03:51:36 UTC,P10276,This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression,"",">Retinoic acid receptor alpha MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEE IVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRC QYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTT NNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPE QDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDM LQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP",RARA,RAR-alpha; Nuclear receptor subfamily 1 group B member 1,462,50772,7.95,">>> Function: retinoic acid receptor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:9864,Nucleus,,"","",None,None,Non Essential,"",RARA,RARA,AF283809,Chromosome:17,17q21 398,"Nitric-oxide synthase, endothelial",2009-05-14 04:27:46 UTC,2009-08-11 22:09:18 UTC,P29474,Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets,"",">Nitric oxide synthase, endothelial MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLTQPPEGPKFPR VKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKR SGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTY ICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT PGNGRFDVLPLLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPA APFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDH HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGI TRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVS LEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKR KESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQ AAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQ SSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPT LLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWL SQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFGCRC SQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMA TNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVP WAFDPPGSDTNSP",NOS3,Endothelial NOS; eNOS; EC-NOS; NOS type III; NOSIII; Constitutive NOS; cNOS,1203,133290,7.27,">>> Function: cofactor binding Function: coenzyme binding Function: NADP binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: tetrapyrrole binding Function: heme binding Function: protein binding Function: calmodulin binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: monooxygenase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen Function: nitric-oxide synthase activity Function: binding Function: nucleotide binding Function: FMN binding Function: catalytic activity Function: oxidoreductase activity || >>> Process: biosynthesis Process: nitric oxide biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Inorganic ion transport and metabolism,"PF00667:FAD_binding_1 PF00258:Flavodoxin_1 PF00175:NAD_binding_1 PF02898:NO_synthase",HGNC:7876,"Cell membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus",,"","",None,None,Non Essential,3NOS,NOS3,NOS3,S80791,"","" 399,Tubulin alpha chain-like 3,2009-05-14 04:56:17 UTC,2009-06-30 03:51:48 UTC,A6NHL2,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin alpha chain-like 3 MRECLSIHIGQAGIQIGDACWELYCLEHGIQPNGVVLDTQQDQLENAKMEHTNASFDTFFCETRAGKHVP RALFVDLEPTVIDGIRTGQHRSLFHPEQLLSGKEDAANNYARGRYSVGSEVIDLVLERTRKLAEQCGGLQ GFLIFRSFGGGTGSGFTSLLMERLTGEYSRKTKLEFSVYPAPRISTAVVEPYNSVLTTHSTTEHTDCTFM VDNEAVYDICHRKLGVECPSHASINRLVVQVVSSITASLRFEGPLNVDLIEFQTNLVPYPRIHFPMTAFA PIVSADKAYHEQFSVSDITTACFESSNQLVKCDPRLGKYMACCLLYRGDVVPKEVNAAIAATKSRHSVQF VDWCPTGFKVGINNRPPTVMPGGDLAKVHRSICMLSNTTAIVEAWARLDHKFDLMYAKRAFLHWYLREGM EEAEFLEAREDLAALERDYEEVAQSF",TUBAL3,"",446,49909,5.96,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:23534,Cytoplasmic,,"","",None,None,Non Essential,"",TUBAL3,TUBAL3,BC105634,Chromosome:10,10p15.1 400,Tubulin beta-8 chain B,2009-05-14 04:59:54 UTC,2009-06-30 03:51:50 UTC,A6NNZ2,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-8 chain B MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYVPRAVLVDLEP GTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVVRKEAESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQLIENADETFCIDNEALYDI CSRTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVAELTQQMFDAKNMMAACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQDKNSSYFADWFPDNVK TAVCDIPPRGLKMSATFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEEEDEEYAEEEVA","","",444,49573,4.49,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C","",Cytoplasmic,,"","",None,None,Non Essential,"","","","","","" 402,Ig gamma-3 chain C region,2009-05-14 05:56:57 UTC,2009-06-30 03:51:47 UTC,P01860,"","",">Ig gamma-3 chain C region ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT VPSSSLGTQTYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPP CPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVD GVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYT LPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQG NIFSCSVMHEALHNRFTQKSLSLSPGK",IGHG3,Heavy chain disease protein; HDC,377,41287,7.95,"","","",HGNC:5527,Secreted,,"","",None,None,Non Essential,"",IGHG3,IGHG3,J00231,Chromosome:14,14q32.33 403,Ig gamma-2 chain C region,2009-05-14 05:57:12 UTC,2009-06-30 03:51:44 UTC,P01859,"","",">Ig gamma-2 chain C region ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT VPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTC VVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAP IEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSD GSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK",IGHG2,"",326,35885,7.66,"","",PF07654:C1-set,HGNC:5526,Secreted,,"","",None,None,Non Essential,"",IGHG2,IGHG2,J00230,Chromosome:14,14q32.33 404,Ig gamma-1 chain C region,2009-05-14 05:57:30 UTC,2009-06-30 03:51:37 UTC,P01857,"","",">Ig gamma-1 chain C region ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKA LPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK",IGHG1,"",330,36106,8.31,"","",PF07654:C1-set,HGNC:5525,Secreted,,"","",None,None,Non Essential,1HZH,IGHG1,IGHG1,"",Chromosome:14,14q32.33 405,Ig gamma-4 chain C region,2009-05-14 05:57:40 UTC,2009-06-30 03:51:37 UTC,P01861,"","",">Ig gamma-4 chain C region ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT VPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPS SIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDS DGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK",IGHG4,"",327,35941,7.41,"","",PF07654:C1-set,HGNC:5528,Secreted,,"","",None,None,Non Essential,"",IGHG4,IGHG4,"",Chromosome:14,14q32.33 406,Sodium channel protein type 1 subunit alpha,2009-05-14 14:51:18 UTC,2009-06-30 03:51:37 UTC,P35498,"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient","",">Sodium channel protein type 1 subunit alpha MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPP EMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILT NCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLG NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQW PPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYM CVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA VVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLS SKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIR GSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSR MLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVS MDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFV DLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIV TLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ LFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGN LVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKP LDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVG ESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFK CCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFT YIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLI ERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFG SFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTR QVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFV VVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV MFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGS SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDAT QFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQME ERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMI IDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK",SCN1A,"Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1; Sodium channel protein, brain I subunit alpha",2009,228974,5.53,">>> Function: voltage-gated ion channel activity Function: voltage-gated sodium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated sodium channel complex Component: cell Component: membrane","","PF00520:Ion_trans PF00612:IQ PF06512:Na_trans_assoc",HGNC:10585,Membrane,,"","",None,"124-147 156-175 189-207 214-233 250-273 400-425 763-787 799-822 831-850 857-876 893-913 967-992 1214-1237 1251-1276 1283-1304 1309-1330 1350-1377 1457-1483 1537-1560 1572-1595 1602-1625 1636-1657 1673-1695 1762-1786",Non Essential,1BYY,SCN1A,SCN1A,X65362,"","" 407,Sodium channel protein type 5 subunit alpha,2009-05-14 14:51:43 UTC,2009-06-30 03:51:41 UTC,Q14524,"This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential in the electrocardiogram","",">Sodium channel protein type 5 subunit alpha MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGN PPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCT ILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFV DLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKC VRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH GYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTEECG EDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTS LLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDT TTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECC PLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS GQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDF CCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIA VAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWK AEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKV WWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGA IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKV NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVII DNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSD IIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGIL FFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADA LSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYE PITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPL GPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV",SCN5A,Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5; Sodium channel protein cardiac muscle subunit alpha; HH1,2016,226942,5.15,">>> Function: voltage-gated ion channel activity Function: voltage-gated sodium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated sodium channel complex Component: cell Component: membrane","","PF00520:Ion_trans PF00612:IQ PF06512:Na_trans_assoc",HGNC:10593,Membrane,,"","",None,"127-150 159-178 192-210 217-236 253-276 390-415 712-736 748-771 780-799 806-825 842-862 914-939 1201-1224 1238-1263 1270-1291 1296-1317 1337-1359 1444-1470 1524-1547 1559-1582 1589-1612 1623-1644 1660-1682 1748-1772",Non Essential,"",SCN5A,SCN5A,M77235,"","" 408,Sodium channel protein type 9 subunit alpha,2009-05-14 14:52:05 UTC,2009-06-30 03:51:45 UTC,Q15858,"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity)","",">Sodium channel protein type 9 subunit alpha MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGDIPPGM VSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNC IFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNV SALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSL ENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWA FLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKE LEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSS GEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGR GRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSL VDGRSALMLPNGQLLPEVIIDKATSDDSGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTV EELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTE EFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLL RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHM NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIE EDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGH NFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLN RSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVE HSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCW LDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLI FWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLL QVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQ DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQS QHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFR VIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFN FETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLV VVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNK VQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQED VSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDS VTKPDKEKYEQDRTEKEDKGKDSKESKK",SCN9A,Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1,1988,226345,6.98,">>> Function: voltage-gated ion channel activity Function: voltage-gated sodium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated sodium channel complex Component: cell Component: membrane","","PF00520:Ion_trans PF00612:IQ PF06512:Na_trans_assoc",HGNC:10597,Membrane,,"","",None,"122-145 154-173 187-205 212-231 248-271 379-404 739-763 775-798 807-826 833-852 869-889 943-968 1188-1211 1225-1250 1257-1278 1283-1304 1324-1351 1431-1457 1511-1534 1546-1569 1576-1599 1610-1631 1647-1669 1736-1760",Non Essential,"",SCN9A,SCN9A,AJ580919,"","" 409,Sodium channel protein type 4 subunit alpha,2009-05-14 14:52:27 UTC,2009-06-30 03:51:48 UTC,P35499,"This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle","",">Sodium channel protein type 4 subunit alpha MARPSLCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIYGD PPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFSMFIMIT ILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFV DLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKC VRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYF LEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG KTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQA LEGGEADGDPAHGKDCNGSLDTSQGEKGAPRQSGSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNC CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLI AMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCM EVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFL LGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELD HLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQ AEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF EDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYS ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCI NTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKE EQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKK PQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDDQSQLKVDILYNINMIFIIIFTGEC VLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRT LLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDG LLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSE PLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDIL FALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQA SYMYRHSHDGSGDDAPEKEGLLANTMSKMYGHENGNSSSPSPEEKGEAGDAGPTMGLMPISPSDTAWPPA PPPGQTVRPGVKESLV",SCN4A,Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4; Sodium channel protein skeletal muscle subunit alpha; SkM1,1836,208034,4.72,">>> Function: voltage-gated ion channel activity Function: voltage-gated sodium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated sodium channel complex Component: cell Component: membrane","","PF00520:Ion_trans PF00612:IQ PF06512:Na_trans_assoc",HGNC:10591,Membrane,,"","",None,"129-150 159-178 191-210 217-236 253-266 424-449 574-597 609-632 641-660 667-686 702-724 777-802 1027-1049 1064-1089 1096-1116 1122-1143 1163-1184 1269-1295 1349-1372 1384-1407 1414-1437 1447-1469 1485-1507 1574-1598",Non Essential,"",SCN4A,SCN4A,S82622,Chromosome:17,17q23-q25.3 410,Sodium channel protein type 3 subunit alpha,2009-05-14 14:52:48 UTC,2009-06-30 03:51:44 UTC,Q9NY46,"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient","",">Sodium channel protein type 3 subunit alpha MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDIPP EMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILT NCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLG NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQW PPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGY ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASK LSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLL SIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNVSQASM SSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSS GRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICI VLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKE CVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFL ALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMS NNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEF SSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGK IWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVG AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNF DNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDN FNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNM VTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMI EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFF FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAAL DPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEP ITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDG SSSTTSPPSYDSVTKPDKEKFEKDKPEKESKGKEVRENQK",SCN3A,"Sodium channel protein type III subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.3; Sodium channel protein, brain III subunit alpha; Voltage-gated sodium channel subtype III",2000,226297,5.49,">>> Function: voltage-gated ion channel activity Function: voltage-gated sodium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated sodium channel complex Component: cell Component: membrane","","PF00520:Ion_trans PF00612:IQ PF06512:Na_trans_assoc",HGNC:10590,Membrane,,"","",None,"124-147 156-175 189-207 214-233 249-273 401-426 755-779 791-814 823-842 849-869 885-905 959-984 1202-1225 1239-1264 1271-1292 1297-1318 1338-1359 1442-1468 1522-1545 1557-1580 1587-1610 1621-1642 1658-1680 1747-1771",Non Essential,1BYY,SCN3A,SCN3A,AF239921,"","" 411,Sodium channel protein type 2 subunit alpha,2009-05-14 14:53:13 UTC,2009-06-30 03:51:41 UTC,Q99250,"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient","",">Sodium channel protein type 2 subunit alpha MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIP PEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTIL TNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQ WPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEG YICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVA SKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYEKRFSSPHQSLL SIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASR ASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTS RQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIV LNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC VCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLA LLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKD SCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTE EFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGK GKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNAL LGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKN VKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMIL ICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMF LAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPS VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSD FADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSK VSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTP EKTDMTPSTTSPPSYDSVTKPEKEKFEKDKSEKEDKGKDIRESKK",SCN2A,"Sodium channel protein type II subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2; Sodium channel protein, brain II subunit alpha; HBSC II",2005,227977,5.42,">>> Function: voltage-gated ion channel activity Function: voltage-gated sodium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated sodium channel complex Component: cell Component: membrane","","PF00520:Ion_trans PF00612:IQ PF06512:Na_trans_assoc",HGNC:10588,Membrane,,"","",None,"125-148 157-176 190-208 215-234 251-274 402-427 754-778 790-813 822-841 848-867 884-904 958-983 1204-1227 1241-1266 1273-1294 1299-1320 1340-1367 1447-1473 1527-1550 1562-1585 1592-1615 1626-1647 1663-1685 1752-1776",Non Essential,1BYY,SCN2A,SCN2A,M55662,"","" 412,Sodium channel protein type 11 subunit alpha,2009-05-14 14:53:45 UTC,2009-06-30 03:51:46 UTC,Q9UI33,"This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization","",">Sodium channel protein type 11 subunit alpha MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQPRPQLDLKASRKLPKLYGDIP RELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVI INCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSY IPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLN LKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFL AMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKM FQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQK KPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCC PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIA LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGA LGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWI ENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFR RAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLGVR HDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQD PRKKSDVTSILSECSTIDLQDGFGWLPEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCY QIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTS AWCCLDFIIVIVSVTTLINLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWL VFCILGVYFFSGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWM DIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQK KYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDH LNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARI GRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASS MLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTA TEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK VTKGDQGDQNDLENGPHSPLQTLCNGDLSSFGVAKGKVHCD",SCN11A,Sodium channel protein type XI subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.9; Sensory neuron sodium channel 2; Peripheral nerve sodium channel 5; hNaN,1791,204924,8.04,">>> Function: voltage-gated ion channel activity Function: voltage-gated sodium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated sodium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF06512:Na_trans_assoc",HGNC:10583,Membrane,,"","",None,"127-148 157-180 193-212 220-239 256-269 377-402 573-596 608-631 640-659 668-687 703-725 786-811 1052-1074 1089-1114 1121-1138 1140-1161 1181-1202 1282-1308 1362-1385 1397-1420 1427-1450 1462-1484 1500-1522 1580-1604",Non Essential,"",SCN11A,SCN11A,AY686224,"","" 413,Amiloride-sensitive sodium channel subunit alpha,2009-05-14 14:54:59 UTC,2009-06-30 03:51:35 UTC,P37088,"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception","",">Amiloride-sensitive sodium channel subunit alpha MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHG AIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRY PEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSL RDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIF ACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGAR VMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY SRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFG SSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPG PAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP",SCNN1A,Epithelial Na(+) channel subunit alpha; Alpha-ENaC; SCNEA; Nonvoltage-gated sodium channel 1 subunit alpha; Alpha-NaCH,669,75704,7.54,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: sodium channel activity Function: amiloride-sensitive sodium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00858:ASC,HGNC:10599,Apical cell membrane,,"","",None,"86-106 563-583",Non Essential,"",SCNN1A,SCNN1A,U81961,Chromosome:12,12p13 414,Amiloride-sensitive sodium channel subunit beta,2009-05-14 14:55:44 UTC,2009-06-30 03:51:41 UTC,P51168,"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception","",">Amiloride-sensitive sodium channel subunit beta MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFAALVCWQWGIF IRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNL NFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTS ATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDK LQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDF PDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRK GIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAK SLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDV IESDSEGDAI",SCNN1B,Epithelial Na(+) channel subunit beta; Beta-ENaC; ENaCB; SCNEB; Nonvoltage-gated sodium channel 1 subunit beta; Beta-NaCH,640,72660,6.26,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: sodium channel activity Function: amiloride-sensitive sodium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00858:ASC,HGNC:10600,Apical cell membrane,,"","",None,"51-71 533-553",Non Essential,1I5H,SCNN1B,SCNN1B,U16023,Chromosome:16,16p12.2-p12.1 415,Sodium channel protein type 8 subunit alpha,2009-05-14 14:56:12 UTC,2009-06-30 03:51:40 UTC,Q9UQD0,"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient","",">Sodium channel protein type 8 subunit alpha MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYG DIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMC TILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEF VNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK CVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGY TSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA TLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKE RRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHN SKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIF PSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSI MSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFM AMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGL SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQ DCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSF SADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTG ADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPE GSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKT CFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFF TNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNV LLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVG AGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMM VETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYF VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEA GIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYI IISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLR VPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTL RRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQR AEEGRRERAKRQKEVRESKC",SCN8A,Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6,1980,225283,6.18,">>> Function: voltage-gated ion channel activity Function: voltage-gated sodium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated sodium channel complex Component: cell Component: membrane","","PF00520:Ion_trans PF00612:IQ PF06512:Na_trans_assoc",HGNC:10596,Membrane,,"","",None,"128-151 160-179 193-211 218-237 253-277 388-413 748-772 784-807 816-835 842-862 878-898 952-977 1194-1217 1231-1256 1263-1284 1289-1310 1330-1351 1438-1464 1518-1541 1553-1576 1583-1606 1617-1638 1654-1676 1742-1766",Non Essential,1BYY,SCN8A,SCN8A,AF225988,Chromosome:12,12q13 416,"Amiloride-sensitive cation channel 1, neuronal",2009-05-14 14:57:25 UTC,2009-06-30 03:51:46 UTC,Q16515,"Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate","",">Amiloride-sensitive cation channel 1, neuronal MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSY QHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQK ANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVK GGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLT YLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLL AEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQK KAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSE TISHTVNVPLQTTLGTLEEIAC",ACCN1,Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel neuronal 1; Acid-sensing ion channel 2; ASIC2; Brain sodium channel 1; BNaC1; BNC1; Mammalian degenerin homolog,512,57710,4.84,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: sodium channel activity Function: amiloride-sensitive sodium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00858:ASC,HGNC:99,Cell membrane,,"","",None,"38-58 428-448",Non Essential,"",ACCN1,ACCN1,BC075043,Chromosome:17,17q12 417,"Amiloride-sensitive cation channel 2, neuronal",2009-05-14 14:57:48 UTC,2009-06-30 03:51:46 UTC,P78348,"Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear (By similarity)","",">Amiloride-sensitive cation channel 2, neuronal MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFH YHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQD KANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTM KDGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRL IYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPAL DFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDD VKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC",ACCN2,Acid-sensing ion channel 1; ASIC1; Brain sodium channel 2; BNaC2,528,59968,5.39,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: sodium channel activity Function: amiloride-sensitive sodium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00858:ASC,HGNC:100,Cell membrane,,"","",None,"45-65 428-448",Non Essential,"",ACCN2,ACCN2,BC013891,Chromosome:12,12q12 418,Amiloride-sensitive cation channel 3,2009-05-14 14:58:24 UTC,2009-06-30 03:51:41 UTC,Q9UHC3,"Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties","",">Amiloride-sensitive cation channel 3 MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREF HHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMP SPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGL DIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWG DCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNC AHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEG LGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL",ACCN3,Neuronal amiloride-sensitive cation channel 3; Acid-sensing ion channel 3; ASIC3; hASIC3; Testis sodium channel 1; hTNaC1,531,58906,7.14,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: sodium channel activity Function: amiloride-sensitive sodium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00858:ASC,HGNC:101,Cell membrane,,"","",None,"44-61 442-460",Non Essential,"",ACCN3,ACCN3,AF195025,"","" 419,Amiloride-sensitive cation channel 4,2009-05-14 14:58:50 UTC,2009-06-30 03:51:39 UTC,Q96FT7,Probable cation channel with high affinity for sodium,"",">Amiloride-sensitive cation channel 4 MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGAAGS GSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALASPSSRGQMPIEIVCKIKFAE EDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLY QAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAA GLRYPEPDMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSG LEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPDSLGGGPEGPCFCPTPCNLTRYGK EISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIG ASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPN HHHPHGPPGGLFEDFAC",ACCN4,"Amiloride-sensitive cation channel 4, pituitary; Acid-sensing ion channel 4",647,70034,7.75,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: sodium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport || >>> Component: cell Component: membrane","",PF00858:ASC,HGNC:21263,Membrane,,"","",None,"196-216 547-567",Non Essential,"",ACCN4,ACCN4,BC073912,"","" 420,Amiloride-sensitive sodium channel subunit delta,2009-05-14 14:59:15 UTC,2009-06-30 03:51:47 UTC,P51172,"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception","",">Amiloride-sensitive sodium channel subunit delta MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIH GAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRR PSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLC NSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHH PTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTE ATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEY CSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQ SHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVL GGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGP QPLETLDT",SCNN1D,Epithelial Na(+) channel subunit delta; Delta-ENaC; SCNED; Nonvoltage-gated sodium channel 1 subunit delta; Delta-NaCH,638,70216,7.90,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: sodium channel activity Function: amiloride-sensitive sodium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00858:ASC,HGNC:10601,Membrane,,"","",None,"87-107 531-551",Non Essential,"",SCNN1D,SCNN1D,BC125074,"","" 421,Amiloride-sensitive sodium channel subunit gamma,2009-05-14 14:59:39 UTC,2009-06-30 03:51:34 UTC,P51170,"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception","",">Amiloride-sensitive sodium channel subunit gamma MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQ CALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREA ESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSND TSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMH GNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETA MVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAA NYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGR QVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSI IARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTL RLERAFSNQLTDTQMLDEL",SCNN1G,Epithelial Na(+) channel subunit gamma; Gamma-ENaC; SCNEG; Nonvoltage-gated sodium channel 1 subunit gamma; Gamma-NaCH,649,74271,7.54,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: sodium channel activity Function: amiloride-sensitive sodium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00858:ASC,HGNC:10602,Apical cell membrane,,"","",None,"56-76 542-562",Non Essential,"",SCNN1G,SCNN1G,U35630,Chromosome:16,16p12 422,Sodium channel protein type 7 subunit alpha,2009-05-14 15:01:21 UTC,2009-06-30 03:51:36 UTC,Q01118,"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient","",">Sodium channel protein type 7 subunit alpha MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPNPDLEVGKKLPFIYGNLSQGMVSEPLEDVD PYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL PKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTART LRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLH NRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLM AQDYPEVLYHLILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGK ELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPC WLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMH PYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDL VLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKT QNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIAS GESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQI SGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYIDQRKTIKILLEYADMIFTYIFI LEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVLSQFERMKVVVRA LIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWEN AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLIT VIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVL ICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLC LPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMY NFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPS VGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSD FAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFK ITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQS QI",SCN7A,Sodium channel protein type VII subunit alpha; Putative voltage-gated sodium channel subunit alpha Nax; Sodium channel protein cardiac and skeletal muscle subunit alpha,1682,193476,8.02,">>> Function: voltage-gated ion channel activity Function: voltage-gated sodium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated sodium channel complex Component: cell Component: membrane","","PF00520:Ion_trans PF06512:Na_trans_assoc",HGNC:10594,Membrane,,"","",None,"114-140 143-168 180-202 204-223 240-264 369-395 501-524 536-559 567-590 593-609 630-650 705-728 930-958 966-991 997-1019 1022-1040 1060-1080 1167-1193 1248-1270 1281-1305 1312-1335 1345-1369 1379-1405 1470-1496",Non Essential,"",SCN7A,SCN7A,M91556,"","" 423,Sodium channel protein type 10 subunit alpha,2009-05-14 15:01:49 UTC,2009-06-30 03:51:50 UTC,Q9Y5Y9,"This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms (By similarity)","",">Sodium channel protein type 10 subunit alpha MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGEL PAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTI LVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG ISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND MAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLF RLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQE ALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFL GLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQPSNP DSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQK CPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIG NIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSW PTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFL IVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNL QVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGP RDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGT GTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCI RHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTD RVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRA LSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKS DCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVI FIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVF DIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWN VFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNI GLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP NLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEK FDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDS LKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLP DEGFVAFTANENCVLPDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP",SCN10A,Sodium channel protein type X subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.8; Peripheral nerve sodium channel 3; hPN3,1956,220628,5.77,">>> Function: voltage-gated ion channel activity Function: voltage-gated sodium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated sodium channel complex Component: cell Component: membrane","","PF00520:Ion_trans PF00612:IQ PF06512:Na_trans_assoc",HGNC:10582,Membrane,,"","",None,"126-149 155-174 188-206 213-232 249-272 374-399 660-684 696-719 728-747 754-773 790-810 865-890 1148-1171 1185-1210 1217-1238 1243-1264 1284-1311 1392-1418 1472-1495 1507-1530 1537-1560 1573-1594 1610-1632 1698-1722",Non Essential,"",SCN10A,SCN10A,AF117907,"","" 424,Amiloride-sensitive cation channel 5,2009-05-14 15:02:20 UTC,2009-06-30 03:51:47 UTC,Q9NY37,"Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride","",">Amiloride-sensitive cation channel 5 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKIRRVLWLVVVL GSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLH LQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTF NHGETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHAR VTIRQVKTVHQEYPWGECNPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSC VSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQWTP PPQNHLGNKNRIEEC",ACCN5,Human intestine Na(+) channel; HINaC,505,57465,8.26,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: sodium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport || >>> Component: cell Component: membrane","",PF00858:ASC,HGNC:17537,Cell membrane,,"","",None,"62-82 460-480",Non Essential,"",ACCN5,ACCN5,CH471056,"","" 425,Putative tubulin beta chain-like protein ENSP00000290377,2009-05-14 15:48:55 UTC,2009-06-30 03:51:37 UTC,A6NKZ8 ,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Putative tubulin beta chain-like protein ENSP00000290377 MDSVRSGPFGQVLRPDNFIFGQCGAGNNWAKGRYTEGAELTESVMDVVRKEAESCDCLQGFQLTHSLGGG TGSGMVTLLISKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQLIENADETFCIDNEALYDICS KTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYR ALTVAELTQQMFDAKNMRAARDPRHGRYLTAAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTA ICDIPPRGLKMSASFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEY QQYQDATAKEEEDEEYAEEEVA","","",372,41775,4.50,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C","",Cytoplasmic,,"","",None,None,Non Essential,"","","","","","" 426,Putative tubulin beta-4q chain,2009-05-14 15:49:21 UTC,2009-06-30 03:51:42 UTC,Q99867,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Putative tubulin beta-4q chain MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYVPRAVLVDLEP GTMDSVRSGPFAEVFRPDNFISRQCGAGNNWAKGRYTEGAELMESVMDVVRKEAESCDCLQGFQLTHSLG GGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQLIENADETFCIDNEALYDI CSRTLKLPTPTYGDLNHLVSATVSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSQGSQQ YRALTVAELTQQMFDAKNMMAARDPRHGCYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNIK TAVCDIPPWGLKMSVTFTGNNTAVQELKRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSE YQQYQDATAEGEGV",TUBB4Q,"",434,48435,4.91,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12413,Cytoplasmic,,"","",None,None,Non Essential,"",TUBB4Q,TUBB4Q,U83668,"","" 427,Putative tubulin-like protein alpha-4B,2009-05-14 15:49:52 UTC,2009-06-30 03:51:40 UTC,Q9H853,"","",">Putative tubulin-like protein alpha-4B MRHQQTERQDPSQPLSRQHGTYRQIFHPEQLITGKEDAANNYAWGHYTIGKEFIDLLLDRIRKLADQCTG LQGFLVFHSLGRGTGSDVTSFLMEWLSVNYGKKSKLGFSIYPAPQVSTAMVQPYNSILTTHTTLEHSDCA FMVDNKAIYDICHCNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVSYLTSTSPWPP MHQSSLQKRYTTSSCWWQRLPMPALSLPTRW",TUBA4B,Alpha-tubulin 4B,241,27552,7.93,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:18637,Cytoplasmic,,"","",None,None,Non Essential,"",TUBA4B,TUBA4B,AK024002,"","" 428,Histone H4-like protein type G,2009-05-14 15:55:48 UTC,2009-06-30 03:51:44 UTC,Q99525,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity)","",">Histone H4-like protein type G MSVRGKAGKGLGKGGAKCHRKVLSDNIQGITKCTIRRLARHGGVKRILGLIYEETRRVFKVFLENVIWYA VTNTEHAKRKTVTAMAVVYVLKRQGRTL",HIST1H4G,"",98,11009,11.67,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:4792,Nucleus (By similarity),,"","",None,None,Non Essential,"",HIST1H4G,HIST1H4G,BC126278,"","" 429,Histone H3-like centromeric protein A,2009-05-14 15:55:57 UTC,2009-06-30 03:51:47 UTC,P49450,"Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division","",">Histone H3-like centromeric protein A MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKEIRKLQKSTHLLIRKLPFSRL AREICVKFTRGVDFNWQAQALLALQEAAEAFLVHLFEDAYLLTLHAGRVTLFPKDVQLARRIRGLEEGLG",CENPA,Centromere protein A; CENP-A; Centromere autoantigen A,140,15991,12.22,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:1851,Nucleus. Centromere. Kinetochore,,"","",None,None,Non Essential,"",CENPA,CENPA,U82609,"","" 430,Histone H3-like,2009-05-14 15:56:55 UTC,2009-06-30 03:51:48 UTC,Q6NXT2,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H3-like MARTKQTARKSTGGKAPRKQLATKAARKSTPSTCGVKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRL VREIAQDFNTDLRFQSAAVGALQEASEAYLVGLLEDTNLCAIHAKRVTIMPKDIQLARRIRGERA","","",135,15214,11.68,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,"",Nucleus,,"","",None,None,Non Essential,1EQZ,"","",BC066906,"","" 431,Voltage-dependent L-type calcium channel subunit alpha-1C,2009-05-14 18:14:23 UTC,2009-06-30 03:51:38 UTC,Q13936,"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds","",">Voltage-dependent L-type calcium channel subunit alpha-1C MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGN ATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVA LAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSA ILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFA FAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGD FQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCG ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTAN KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF QILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEE EEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNP ETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFI LLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLH KGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDN VLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ EQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDA WNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWT FIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIM LACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH HLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATL FALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFK KRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGL FGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANN TALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAGTQAHCLL LRKANPSRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKR DIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPAS FPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLM VPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAP QSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGAPSEEELQDSRVYVSSL",CACNA1C,"Voltage-gated calcium channel subunit alpha Cav1.2; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle",2221,248894,6.70,">>> Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated calcium channel complex Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF08763:Ca_chan_IQ PF00520:Ion_trans",HGNC:1390,Membrane,,"","",None,"125-143 161-181 194-212 233-251 271-290 381-405 525-543 559-578 587-605 616-634 654-673 729-753 901-919 936-955 988-1006 1014-1032 1052-1071 1162-1186 1240-1258 1274-1293 1302-1320 1373-1391 1411-1430 1500-1524",Non Essential,1VYT,CACNA1C,CACNA1C,M91370,Chromosome:12,12p13.3 432,Ig epsilon chain C region,2009-05-14 18:30:33 UTC,2009-05-14 18:30:33 UTC,P01854 ,"","","","","","","","","","","","","","",,,,,,,,,,, 433,Ig alpha-1 chain C region,2009-05-14 18:35:13 UTC,2009-06-30 03:51:50 UTC,P01876,Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system,"",">Ig alpha-1 chain C region ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQL TLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLG SEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPE SKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWA SRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDG TCY",IGHA1,"",353,37655,6.49,"","",PF07654:C1-set,HGNC:5478,"",,"","",None,None,Non Essential,1IGA,IGHA1,IGHA1,"",Chromosome:14,14q32.33 434,Ig mu chain C region,2009-05-14 18:48:59 UTC,2009-06-30 03:51:35 UTC,P01871,"","",">Ig mu chain C region GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYKNNSDISSTRGFPSVLRGGKYAATSQ VLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFS PRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNA SSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNA TFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATIT CLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALP NRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY",IGHM,"",452,49307,6.77,"","","",HGNC:5541,Isoform 2:Cell membrane,,"","",None,None,Non Essential,1QLR,IGHM,IGHM,K01310,Chromosome:14,14q32.33 435,Voltage-dependent P/Q-type calcium channel subunit alpha-1A,2009-05-14 19:49:47 UTC,2009-06-30 03:51:35 UTC,O00555,"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA)","",">Voltage-dependent P/Q-type calcium channel subunit alpha-1A MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQN CLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYF IGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIP SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPART CPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFF MLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGA LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFY WTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVII GSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL LGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLF GNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKP AKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSR AAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGRESDHHAREGS LEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHRAHRRPGEEGPEDKAERRARH REGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRP IQQDLGRQDPPLAEDIDNMKNNKLATAESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNA ASRRTPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNA NPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA LAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAF TGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFK GKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSV DATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAIS AKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFS LECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLF RSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD SSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNT VHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAM MIMEYYRQSKAKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPS WVTQRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE NQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSHRASERSLGR YTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRAR ARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGS GPPQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPR ACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRS PRTPRASGPACASPSRHGRRLPNGYYPAHGLARPRGPGSRKGLHEPYSESDDDWC",CACNA1A,"Voltage-gated calcium channel subunit alpha Cav2.1; Calcium channel, L type, alpha-1 polypeptide isoform 4; Brain calcium channel I; BI",2505,282368,9.10,">>> Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated calcium channel complex Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF08763:Ca_chan_IQ PF00520:Ion_trans",HGNC:1388,Membrane,,"","",None,"99-117 136-155 168-185 191-209 229-248 336-360 488-506 522-541 550-568 579-597 617-636 690-714 1243-1261 1278-1297 1310-1328 1340-1358 1378-1397 1485-1509 1565-1593 1599-1618 1627-1645 1653-1671 1691-1710 1783-1807",Non Essential,"",CACNA1A,CACNA1A,S76537,Chromosome:19,19p13.2-p13.1 436,Voltage-dependent L-type calcium channel subunit alpha-1S,2009-05-14 19:50:34 UTC,2009-06-30 03:51:49 UTC,Q13698,"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle","",">Voltage-dependent L-type calcium channel subunit alpha-1S MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAV YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILE QVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIY AIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGF SMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTF QKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRI FRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQ YFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIA SLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGP SYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKST MAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKA VPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFT SVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINR AKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDP MQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYII LIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYF EYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIV IGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILL ACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLD EFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFAL VRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQ EEYYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDN FLERTNSLPPVMANQRPLQFAEIEMEEMESPVFLEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHV FSSVHYEREFPEETETPATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAMPRGQAPPAPCQCPRVESSM PEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQALADACQM EPEEVEIMATELLKGREAPEGMASSLGCLNLGSSLGSLDQHQGSQETLIPPRL",CACNA1S,"Voltage-gated calcium channel subunit alpha Cav1.1; Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle",1873,212353,6.54,">>> Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated calcium channel complex Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF08763:Ca_chan_IQ PF00520:Ion_trans",HGNC:1397,Membrane,,"","",None,"52-70 89-108 121-139 161-179 199-218 310-334 433-451 467-486 495-513 524-542 562-581 637-661 800-818 835-854 867-885 893-911 931-950 1041-1065 1119-1137 1153-1172 1181-1199 1232-1250 1270-1289 1357-1381",Non Essential,"",CACNA1S,CACNA1S,U09784,"","" 437,Voltage-dependent L-type calcium channel subunit alpha-1F,2009-05-14 19:51:09 UTC,2009-06-30 03:51:38 UTC,O60840,"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA)","",">Voltage-dependent L-type calcium channel subunit alpha-1F MSESEGGKDTTPEPSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTVAVASAQRSPR ALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTV ETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRV LRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDP SPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWV YFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPS ADDNLGPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNK IMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCL FTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWAS LSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGE DWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEKD LPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAF FCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILL KMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQ CVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERL WVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNI FVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLIL LNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAV TEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIY AVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFT CGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLD VVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELR IVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGL RSLQDLGPEMRQALTCDTEEEEEEGQEGVEEEDEKDLETNKATMVSQPSARRGSGISVSLPVGDRLPDSL SFGPSDDDRGTPTSSQPSVPQAGSNTHRRGSGALIFTIPEEGNSQPKGTKGQNKQDEDEEVPDRLSYLDE QAGTPPCSVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQGSCEDLPIPGTYHRGRNSGP NRAQGSWATPPQRGRLLYAPLLLVEEGAAGEGYLGRSSGPLRTFTCLHVPGTHSDPSHGKRGSADSLVEA VLISEGLGLFARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEM ACVHAL",CACNA1F,Voltage-gated calcium channel subunit alpha Cav1.4,1966,219498,5.96,">>> Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated calcium channel complex Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF08763:Ca_chan_IQ PF00520:Ion_trans",HGNC:1393,Membrane,,"","",None,"93-111 130-149 162-180 202-220 240-259 348-372 519-538 554-572 581-599 610-628 648-668 723-747 861-879 896-915 928-946 953-972 992-1011 1102-1122 1180-1198 1214-1233 1241-1262 1280-1299 1319-1338 1406-1430",Non Essential,1VYT,CACNA1F,CACNA1F,U93305,"","" 438,Voltage-dependent T-type calcium channel subunit alpha-1H,2009-05-14 19:51:31 UTC,2009-06-30 03:51:37 UTC,O95180,"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the ""low-voltage activated (LVA)"" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes","",">Voltage-dependent T-type calcium channel subunit alpha-1H MTEGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAELGADEEQRV PYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFD AFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAI NRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQ TEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSG DSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT QFSETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKV DPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPP SPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPTILPSGVGSGKGSTSP GPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPG EPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEM LLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL YNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQT TELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKP PASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRA TPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEP YKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRL LRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTK AQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLL IVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSI HSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDR WNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG NLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRE CSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPGS ARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGT PLGSVASVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDS PRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEE VSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAKA WGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGA GGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEP PMPVGDPPEKRRGLYLTVPQCPLEKPGSPSATPAPGGGADDPV",CACNA1H,Voltage-gated calcium channel subunit alpha Cav3.2; Low-voltage-activated calcium channel alpha1 3.2 subunit,2353,259166,7.38,">>> Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated calcium channel complex Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,PF00520:Ion_trans,HGNC:1395,Membrane,,"","",None,"101-119 140-160 170-184 194-212 233-253 395-419 794-814 828-849 856-874 883-906 918-938 991-1015 1291-1313 1332-1352 1363-1382 1397-1418 1429-1452 1530-1555 1617-1637 1652-1673 1681-1699 1714-1737 1752-1772 1836-1863",Non Essential,"",CACNA1H,CACNA1H,AF223563,Chromosome:16,16p13.3 439,Voltage-dependent T-type calcium channel subunit alpha-1G,2009-05-14 19:52:17 UTC,2009-06-30 03:51:45 UTC,O43497,"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the ""low-voltage activated (LVA)"" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes","",">Voltage-dependent T-type calcium channel subunit alpha-1G MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRP RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALG IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPM LGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMR SCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQV ITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLS VHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHAD CHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYS SMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDA QHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL WAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASG QLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSL PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLK RRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGR GSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKL VVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF HKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTS HYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQEST CYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPF LWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQP SAFPSAPSLGGSDPQIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPG PDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFW GQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSP RDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPS ITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP",CACNA1G,Voltage-gated calcium channel subunit alpha Cav3.1; Cav3.1c; NBR13,2377,262474,6.57,">>> Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated calcium channel complex Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","",PF00520:Ion_trans,HGNC:1394,Membrane,,"","",None,"81-101 120-141 151-170 176-193 214-234 371-395 744-764 778-799 806-824 833-856 868-888 940-964 1273-1295 1314-1334 1345-1364 1379-1400 1411-1434 1512-1537 1611-1631 1646-1667 1675-1693 1708-1731 1746-1766 1827-1854",Non Essential,"",CACNA1G,CACNA1G,AF029229,Chromosome:17,17q22 440,Voltage-dependent L-type calcium channel subunit beta-1,2009-05-14 19:52:30 UTC,2009-06-30 03:51:50 UTC,Q02641,"The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting","",">Voltage-dependent L-type calcium channel subunit beta-1 MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDS DVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKY NNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPASA KQKQKSTEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSV LNNPSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPK VLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP NPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLERATGEHASMHEYPGELGQPPGLYPSSHPPGRAGT LRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGPGLGDPAGGGTPPARQGSWEDEEEDYEEELT DNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR",CACNB1,CAB1; Calcium channel voltage-dependent subunit beta 1,598,65714,6.75,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: Not Available","","PF00774:Ca_channel_B PF00018:SH3_1",HGNC:1401,"Cell membrane, sarcolemma",,"","",None,None,Non Essential,"",CACNB1,CACNB1,Z21726,Chromosome:17,17q21-q22 441,"Calcium channel, alpha 2/delta subunit 2",2009-05-14 19:53:04 UTC,2009-07-22 22:37:04 UTC,Q9NY47,"The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis","",">Voltage-dependent calcium channel subunit alpha-2/delta-2 MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRPTSGPPRPLWLLLPLLPLLAAPGASAYSFPQQHTM QHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADA AENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQI PTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRP WYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQANV RNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRANCNKMIMMFTDGGEDRVQDVFEKYNWPNRT VRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAKQVQWTNVYE DALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLL HPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYIDEVTRNYTWVPI RSTNYSLGLVLPPYSTFYLQANLSDQILQVKLRISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDN NTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVF PNKAAEDWTENPEPFNASFYRRSLDNHGYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPA VVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQ VGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWS LFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNT NLLFVVAEKPLCSQCEAGRLLQKETHSDGPEQCELVQRPRYRRGPHICFDYNATEDTSDCGRGASFPPSL GVLVSLQLLLLLGLPPRPQPQVLVHASRRL",CACNA2D2,Voltage-gated calcium channel subunit alpha-2/delta-2; Contains: RecName: Voltage-dependent calcium channel subunit alpha-2-2; Contains: RecName: Voltage-dependent calcium channel subunit delta-2,1150,129877,5.62,">>> Function: Not Available || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF02743:Cache_1 PF08473:VGCC_alpha2 PF00092:VWA PF08399:VWA_N",HGNC:1400,Membrane,,"","",1-18,1114-1134,Non Essential,"",CACNA2D2,CACNA2D2,AB011130,"","" 442,Voltage-dependent N-type calcium channel subunit alpha-1B,2009-05-14 19:53:31 UTC,2009-06-30 03:51:37 UTC,Q00975,"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons","",">Voltage-dependent N-type calcium channel subunit alpha-1B MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFT VNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQ VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGD TECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNL VLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAA TKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLC VVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFE VVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQL FGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTL LNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQ RASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAAE APEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGP GPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHR ARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKELRNHQPREPHCDLETSGTVTVGPMHTLPSTCLQK VEEQPEDADNQRNVTRMGSQPPDPNTIVHIPVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSG PRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIF TGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLK TIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYE KEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYF VVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVS PPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDF VTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF FIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECG SDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMF EMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAE LRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLF HPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHS TEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPR GTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRR ERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVNG SPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQ RDPLSQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRV PNGYHCTLGLSSGGRARHSYHHPDQDHWC",CACNA1B,"Voltage-gated calcium channel subunit alpha Cav2.2; Calcium channel, L type, alpha-1 polypeptide isoform 5; Brain calcium channel III; BIII",2339,262499,8.62,">>> Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated calcium channel complex Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","Translation, ribosomal structure and biogenesis",PF00520:Ion_trans,HGNC:1389,Membrane,,"","",None,"96-114 133-152 164-183 188-206 226-245 332-356 483-501 517-536 545-562 574-592 612-631 685-709 1152-1169 1186-1205 1218-1236 1247-1265 1285-1304 1392-1416 1472-1490 1506-1525 1534-1552 1564-1582 1602-1621 1684-1708",Non Essential,"",CACNA1B,CACNA1B,U76666,"","" 443,Voltage-dependent R-type calcium channel subunit alpha-1E,2009-05-14 19:53:58 UTC,2009-06-30 03:51:35 UTC,Q15878,"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega- conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega- Aga-IVA). Calcium channels contaning alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing","",">Voltage-dependent R-type calcium channel subunit alpha-1E MARFGEAVVARPGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNRSLF IFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAG IKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIV LKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECK DWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVL SGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRT EAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNT ACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIF RPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN FNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLA IAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERR RRHHMSVWEQRTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGL ALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFED RARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDHELRGNHGAKEPTIQEERAQD LRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVVLTEQEPEGSSEQALLGNVQLDMGRVISQSE PDLSCITANTDKATTESTSVTVAIPDVDPLVDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEK RETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVL RVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECI GNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMS IFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYR VWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRD TWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEP DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAE YDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIK IAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL EEQKNAPMFQRMEPSSLPQEIIANAKALPYLQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQF QERQSLEPEVSELKSVQPSNHGIYLPSDTQEHAGSGRASSMPRLTVDPQVVTDPSSMRRSFSTIRDKRSN SSWLEEFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKHLLSPDVSRC NSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPRRSRRQLPPVPPKPRPLL SYSSLIRHAGSISPPADGSEEGSPLTSQALESNNACLTESSNSPHPQQSQHASPQRYISEPYLALHEDSH ASDCGEEETLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVNNLLSDTEED DKC",CACNA1E,"Voltage-gated calcium channel subunit alpha Cav2.3; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Brain calcium channel II; BII",2313,261735,8.31,">>> Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated calcium channel complex Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF08763:Ca_chan_IQ PF00520:Ion_trans",HGNC:1392,Membrane,,"","",None,"90-108 128-146 159-173 186-205 224-244 327-350 477-496 510-529 539-557 568-586 606-625 679-703 1149-1165 1190-1209 1218-1240 1255-1272 1292-1311 1399-1422 1480-1498 1514-1533 1542-1560 1572-1590 1610-1629 1699-1724",Non Essential,"",CACNA1E,CACNA1E,AL590998,"","" 444,Voltage-dependent calcium channel subunit alpha-2/delta-3,2009-05-14 19:54:24 UTC,2009-06-30 03:51:41 UTC,Q8IZS8,"The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity)","",">Voltage-dependent calcium channel subunit alpha-2/delta-3 MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKY KEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERD KDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLI WQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVS SILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILS DFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQ ISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNET RSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLS EVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFFR GNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVV SAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWY RRAAEQIPGSFVYSIPFSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCAS LDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRAN KESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSER TIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRR RPESCHGFHPEENARECGGAPSLQAQTVLLLLPLLLMLFSR",CACNA2D3,Voltage-gated calcium channel subunit alpha-2/delta-3; Contains: RecName: Voltage-dependent calcium channel subunit alpha-2-3; Contains: RecName: Voltage-dependent calcium channel subunit delta-3,1091,123012,5.54,">>> Function: Not Available || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF02743:Cache_1 PF00092:VWA PF08399:VWA_N",HGNC:15460,Membrane,,"","",1-28,1069-1089,Non Essential,"",CACNA2D3,CACNA2D3,AF516696,"","" 445,Voltage-dependent L-type calcium channel subunit alpha-1D,2009-05-14 19:54:54 UTC,2009-06-30 03:51:37 UTC,Q01668,"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA)","",">Voltage-dependent L-type calcium channel subunit alpha-1D MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMS TSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANC VALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLF SVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF VIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNF AFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCG SLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANK VLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVT RHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAE EKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIR SHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVV KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKS NPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIP KNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK PKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLL SRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLF RCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYL TRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATF LIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQV PTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQL PTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGF LEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPD ISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITTL",CACNA1D,"Voltage-gated calcium channel subunit alpha Cav1.3; Calcium channel, L type, alpha-1 polypeptide, isoform 2",2161,245144,6.73,">>> Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated calcium channel complex Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF08763:Ca_chan_IQ PF00520:Ion_trans",HGNC:1391,Membrane,,"","",None,"127-145 164-183 196-214 236-254 274-293 382-406 524-543 559-577 586-604 615-633 653-673 728-752 887-905 922-941 954-972 979-998 1018-1037 1128-1148 1206-1224 1240-1259 1267-1288 1314-1333 1353-1372 1440-1464",Non Essential,1VYT,CACNA1D,CACNA1D,D43747,"","" 446,Voltage-dependent T-type calcium channel subunit alpha-1I,2009-05-14 19:55:48 UTC,2009-06-30 03:51:36 UTC,Q9P0X4,"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the ""low-voltage activated (LVA)"" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity)","",">Voltage-dependent T-type calcium channel subunit alpha-1I MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRN WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLG NVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGC HEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVI FQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGK TKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHED GRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRETR AKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYL RNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLM LFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTP NGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGR SAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRH RHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEE EIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALE RPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKG KFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYY ATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVA FGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLD TVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAEL ELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTI IDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGE LDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPM PAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQT TLEDSLTLSDSPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAAL AHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASKRKR",CACNA1I,Voltage-gated calcium channel subunit alpha Cav3.3; Ca(v)3.3,2223,245106,6.52,">>> Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated calcium channel complex Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","",PF00520:Ion_trans,HGNC:1396,Membrane,,"","",None,"79-99 121-141 149-168 174-191 212-232 378-398 641-661 677-697 703-721 730-753 765-785 842-862 1167-1187 1210-1230 1245-1265 1273-1294 1305-1325 1411-1431 1486-1506 1523-1543 1557-1577 1584-1607 1622-1642 1710-1730",Non Essential,"",CACNA1I,CACNA1I,AB032946,Chromosome:22,22q13.1 447,Voltage-dependent calcium channel subunit alpha-2/delta-1,2009-05-14 19:56:19 UTC,2009-06-30 03:51:43 UTC,P54289,The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity),"",">Voltage-dependent calcium channel subunit alpha-2/delta-1 MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTV EPNNARQLVEIAARDIEKLLSNRSKALVSLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEP GSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGS ATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEML ETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVS RANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRVFRFSVGQHNYERGPIQWMACENKGYYYEIPSIGAIR INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGV DVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMI DGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARSKKGKM KDSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFT NELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNK SGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVI LDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVP SVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSG VLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDN NVLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL",CACNA2D1,Voltage-gated calcium channel subunit alpha-2/delta-1; Contains: RecName: Voltage-dependent calcium channel subunit alpha-2-1; Contains: RecName: Voltage-dependent calcium channel subunit delta-1,1091,123184,4.86,">>> Function: Not Available || >>> Process: Not Available || >>> Component: cell Component: membrane",Cell motility,"PF02743:Cache_1 PF08473:VGCC_alpha2 PF00092:VWA PF08399:VWA_N",HGNC:1399,Membrane,,"","",1-24,1062-1082,Non Essential,"",CACNA2D1,CACNA2D1,M76559,"","" 448,Voltage-dependent calcium channel subunit alpha-2/delta-4,2009-05-14 19:56:43 UTC,2009-06-30 03:51:45 UTC,Q7Z3S7,The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel,"",">Voltage-dependent calcium channel subunit alpha-2/delta-4 MVCGCSALLPLPNPRPTMPATPNFLANPSSSSRWIPLQPMPVAWAFVQKTSALLWLLLLGTSLSPAWGQA KIPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVESSLKIEEVDGLELVRKFSEDMENMLRRKVEA VQNLVEAAEEADLNHEFNESLVFDYYNSVLINERDEKGNFVELGAEFLLESNAHFSNLPVNTSISSVQLP TNVYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDCRNRG WYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFVNIIAYNDYVHYIEPCFKGILVQA DRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGAVEDYEPVFEKYNW PDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADTQENVMEYLHVLSRPMVINHDHDIIWTEA YMDSKLLSSQAQSLTLLTTVAMPVFSKKNETRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTN NGYILSHPDLRPLYREGKKLKPKPNYNSVDLSEVEWEDQAESLRTAMINRETGTLSMDVKVPMDKGKRVL FLTNDYFFTDISDTPFSLGVVLSRGHGEYILLGNTSVEEGLHDLLHPDLALAGDWIYCITDIDPDHRKLS QLEAMIRFLARKDPDLECDEELVREVLFDAVVTAPMEAYWTALALNMSEESEHVVDMAFLGTRAGLLRSS LFVGSEKVSDRKFLTPEDEASVFTLDRFPLWYRQASEHPAGSFVFNLRWAEGPESAGEPMVVTASTAVAV TVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPCTQSCEDSDLDCFVIDNNGFILISKRSRETGR FLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQPLVSPISAFLTATRWLLQELVLFLLEWS VWGSWYDRGAEAKSVFHHSHKHKKQDPLQPCDTEYPVFVYQPAIREANGIVECEPCQKVFVVQQIPNSNL LLLVTDPTCDCSIFPPVLQEATEVKYNASVKCDRMRSQKLRRRPDSCHAFHPEENAQDCGGASDTSASPP LLLLPVCAWGLLPQLLR",CACNA2D4,Voltage-gated calcium channel subunit alpha-2/delta-4; Contains: RecName: Voltage-dependent calcium channel subunit alpha-2-4; Contains: RecName: Voltage-dependent calcium channel subunit delta-4,1137,127967,4.97,">>> Function: Not Available || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF02743:Cache_1 PF00092:VWA PF08399:VWA_N",HGNC:20202,Membrane,,"","",1-19,1116-1136,Non Essential,"",CACNA2D4,CACNA2D4,BC048288,Chromosome:12,12p13.33 449,Voltage-dependent L-type calcium channel subunit beta-4,2009-05-14 19:57:08 UTC,2009-06-30 03:51:40 UTC,O00305,"The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting","",">Voltage-dependent L-type calcium channel subunit beta-4 MSSSSYAKNGTADGPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDR EAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGR LVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHI PPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAII ERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRG KSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGS TALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEE DYPDSYQDTYKPHRNRGSPGGYSHDSRHRL",CACNB4,CAB4; Calcium channel voltage-dependent subunit beta 4,520,58170,9.77,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: Not Available","",PF00774:Ca_channel_B,HGNC:1404,"",,"","",None,None,Non Essential,1VYV,CACNB4,CACNB4,AF038852,"","" 450,Voltage-dependent L-type calcium channel subunit beta-3,2009-05-14 19:57:44 UTC,2009-06-30 03:51:36 UTC,P54284,"The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting","",">Voltage-dependent L-type calcium channel subunit beta-3 MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSY CGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGN PSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDG RISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQL AKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLA EYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQR SSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWPKDSY",CACNB3,CAB3; Calcium channel voltage-dependent subunit beta 3,484,54532,6.31,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: Not Available","",PF00774:Ca_channel_B,HGNC:1403,"",,"","",None,None,Non Essential,1VYT,CACNB3,CACNB3,BC041811,Chromosome:12,12q13 451,Voltage-dependent L-type calcium channel subunit beta-2,2009-05-14 19:58:01 UTC,2009-06-30 03:51:45 UTC,Q08289,"The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting","",">Voltage-dependent L-type calcium channel subunit beta-2 MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVR QGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAI SFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGD IVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPS MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSS LAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLN VQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPT LASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQ ESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKS KDRYCEKDGEVISKKRNEAGEWNRDVYIRQ",CACNB2,CAB2; Calcium channel voltage-dependent subunit beta 2; Lambert-Eaton myasthenic syndrome antigen B; MYSB,660,73581,8.26,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: Not Available","","PF00774:Ca_channel_B PF00018:SH3_1",HGNC:1402,"Cell membrane, sarcolemma",,"","",None,None,Non Essential,"",CACNB2,CACNB2,AF465485,Chromosome:10,10p12 452,Voltage-dependent calcium channel gamma-7 subunit,2009-05-14 19:58:32 UTC,2009-06-30 03:51:49 UTC,P62955,Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity),"",">Voltage-dependent calcium channel gamma-7 subunit MSHCSSRALTLLSSVFGACGLLLVGIAVSTDYWLYMEEGTVLPQNQTTEVKMALHAGLWRVCFFAGREKG RCVASEYFLEPEINLVTENTENILKTVRTATPFPMVSLFLVFTAFVISNIGHIRPQRTILAFVSGIFFIL SGLSLVVGLVLYISSINDEVMNRPSSSEQYFHYRYGWSFAFAASSFLLKEGAGVMSVYLFTKRYAEEEMY RPHPAFYRPRLSDCSDYSGQFLQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHISTSPC",CACNG7,Neuronal voltage-gated calcium channel gamma-7 subunit,275,31003,7.15,">>> Function: Not Available || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane","",PF00822:PMP22_Claudin,HGNC:13626,Membrane,,"","",None,"8-28 103-123 129-149 179-199",Non Essential,"",CACNG7,CACNG7,BC113503,Chromosome:19,19q13.4 453,Transient receptor potential cation channel subfamily V member 6,2009-05-14 20:00:00 UTC,2009-06-30 03:51:45 UTC,Q9H1D0,"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity)","",">Transient receptor potential cation channel subfamily V member 6 MGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDC KVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARR ASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKT FACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDL TEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYR PLKPRTNNRTSPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTI LGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDL MRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYA AFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLGDRWF LRVEDRQDLNRQRIQRYAQAFHTRGSEDLDKDSVEKLELGCPFSPHLSLPMPSVSRSTSRSSANWERLRQ GTLRRDLRGIINRGLEDGESWEYQI",TRPV6,TrpV6; Epithelial calcium channel 2; ECaC2; Calcium transport protein 1; CaT1; CaT-like; CaT-L,725,83211,7.66,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans",HGNC:14006,Cell membrane,,"","",None,"329-349 388-408 420-440 449-469 493-513 557-577",Non Essential,"",TRPV6,TRPV6,AY225461,"","" 454,Calcium release-activated calcium channel protein 1,2009-05-14 20:00:37 UTC,2009-06-30 03:51:45 UTC,Q96D31,"Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT","",">Calcium release-activated calcium channel protein 1 MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHS MQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMI STCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPR PTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFA RLQDQLDHRGDHPLTPGSHYA",ORAI1,Protein orai-1; Transmembrane protein 142A,301,32669,8.50,"","",PF07856:DUF1650,HGNC:25896,Cell membrane,,"","",None,"88-105 120-140 174-194 235-255",Non Essential,"",ORAI1,ORAI1,BC075831,Chromosome:12,12q24.31 455,Voltage-dependent calcium channel gamma-8 subunit,2009-05-14 20:01:46 UTC,2009-06-30 03:51:48 UTC,Q8WXS5,Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity),"",">Voltage-dependent calcium channel gamma-8 subunit MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGG GGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLL LGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGG LSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRS SEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGG GGAGAERDRGGSSGFLTLHNAFPKEAGGGVTVTVTRPPAPPAPRHPAPSAPAPGTLAKGAAASNTNTLNR KTTPV",CACNG8,Neuronal voltage-gated calcium channel gamma-8 subunit,425,43481,9.85,">>> Function: structural molecule activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane Component: plasma membrane Component: cell junction Component: intercellular junction Component: tight junction",Carbohydrate transport and metabolism,PF00822:PMP22_Claudin,HGNC:13628,Membrane,,"","",None,"19-39 129-149 158-178 208-228 318-338",Non Essential,"",CACNG8,CACNG8,AF288388,Chromosome:19,19q13.4 456,Voltage-dependent calcium channel gamma-3 subunit,2009-05-14 20:02:17 UTC,2009-06-30 03:51:35 UTC,O60359,Thought to stabilize the calcium channel in an inactivated (closed) state,"",">Voltage-dependent calcium channel gamma-3 subunit MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTHSGLWRTCCLE GAFRGVCKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFHRSRHNVILSAGI FFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRAK SHSEFLKKSTFARLPPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKITMGTLL NSDRDHAFLQFHNSTPKEFKESLHNNPANRRTTPV",CACNG3,Neuronal voltage-gated calcium channel gamma-3 subunit,315,35549,9.84,">>> Function: structural molecule activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane Component: plasma membrane Component: cell junction Component: intercellular junction Component: tight junction","",PF00822:PMP22_Claudin,HGNC:1407,Membrane,,"","",None,"8-28 104-124 135-155 181-201",Non Essential,"",CACNG3,CACNG3,BC040005,Chromosome:16,16p12-p13.1 457,Voltage-dependent calcium channel gamma-1 subunit,2009-05-14 20:02:35 UTC,2009-06-30 03:51:49 UTC,Q06432,This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple subunit complex,"",">Voltage-dependent calcium channel gamma-1 subunit MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRICTKRIPMDDSKTCG PITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPA SMFYAFAGLCILVSVEVMRQSVKRMIDSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRMPRN PWESCMDAEPEH",CACNG1,"Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma",222,25029,7.10,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","",PF00822:PMP22_Claudin,HGNC:1405,Membrane,,"","",None,"11-29 105-129 140-155 180-204",Non Essential,"",CACNG1,CACNG1,Z19587,Chromosome:17,17q24 458,Voltage-dependent calcium channel gamma-6 subunit,2009-05-14 20:02:55 UTC,2009-06-30 03:51:40 UTC,Q9BXT2,Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity),"",">Voltage-dependent calcium channel gamma-6 subunit MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNTYKA NGSAVCEAAHLGLWKACTKRLWQADVPVDRDTCGPAELPGEANCTYFKFFTTGENARIFQRTTKKEVNLA AAVIAVLGLAVMALGCLCIIMVLSKGAEFLLRVGAVCFGLSGLLLLVSLEVFRHSVRALLQRVSPEPPPA PRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSWPWGSLCPKRGHRAT",CACNG6,Neuronal voltage-gated calcium channel gamma-6 subunit,260,28129,9.44,">>> Function: structural molecule activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane Component: plasma membrane Component: cell junction Component: intercellular junction Component: tight junction","","",HGNC:13625,Membrane,,"","",None,"43-63 143-163 169-189 221-241",Non Essential,"",CACNG6,CACNG6,BC021552,Chromosome:19,19q13.4 459,Two pore calcium channel protein 2,2009-05-14 20:03:40 UTC,2009-06-30 03:51:41 UTC,Q8NHX9,May function as one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane (By similarity),"",">Two pore calcium channel protein 2 MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASS MWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL SVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIR WSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP AYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGA FPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIP SMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHK WDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWLCR",TPCN2,Voltage-dependent calcium channel protein TPC2,752,85244,7.10,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00520:Ion_trans,HGNC:20820,Membrane,,"","",None,"85-105 156-176 219-239 290-310 337-357 440-460 466-486 503-523 555-575 581-601 639-659 674-694",Non Essential,"",TPCN2,TPCN2,AL137479,Chromosome:11,11q13.2 460,Voltage-dependent calcium channel gamma-2 subunit,2009-05-14 20:04:00 UTC,2009-06-30 03:51:47 UTC,Q9Y698,Thought to stabilize the calcium channel in an inactivated (closed) state,"",">Voltage-dependent calcium channel gamma-2 subunit MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLE GNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGI FFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRA TARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKA ATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV",CACNG2,Neuronal voltage-gated calcium channel gamma-2 subunit,323,35966,9.22,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: structural molecule activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane Component: plasma membrane Component: cell junction Component: intercellular junction Component: tight junction","",PF00822:PMP22_Claudin,HGNC:1406,Membrane,,"","",None,"10-30 104-124 134-154 182-202",Non Essential,"",CACNG2,CACNG2,BC112299,Chromosome:22,22q13.1 461,Voltage-dependent calcium channel gamma-5 subunit,2009-05-14 20:04:16 UTC,2009-06-30 03:51:38 UTC,Q9UF02,Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity),"",">Voltage-dependent calcium channel gamma-5 subunit MSACGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLEEGVIVPQNQSTEIKMSLHSGLWRVCFLAGEERG RCFTIEYVMPMNTQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILNNIGHIRPHRTILAFVSGIFFIL SGLSLVVGLVLYISSINDEMLNRTKDAETYFNYKYGWSFAFAAISFLLTESAGVMSVYLFMKRYTAEDMY RPHPGFYRPRLSNCSDYSGQFLHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSSSPC",CACNG5,Neuronal voltage-gated calcium channel gamma-5 subunit,275,30903,7.38,">>> Function: Not Available || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane","",PF00822:PMP22_Claudin,HGNC:1409,Membrane,,"","",None,"8-28 103-123 129-149 176-196",Non Essential,"",CACNG5,CACNG5,BC101633,Chromosome:17,17q24 462,Voltage-dependent calcium channel gamma-4 subunit,2009-05-14 20:04:51 UTC,2009-06-30 03:51:38 UTC,Q9UBN1,Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity),"",">Voltage-dependent calcium channel gamma-4 subunit MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTDYWLYSSAHICNGTNLTMDDGPPPRRARGDLTHSGLWRVC CIEGIYKGHCFRINHFPEDNDYDHDSSEYLLRIVRASSVFPILSTILLLLGGLCIGAGRIYSRKNNIVLS AGILFVAAGLSNIIGIIVYISSNTGDPSDKRDEDKKNHYNYGWSFYFGALSFIVAETVGVLAVNIYIEKN KELRFKTKREFLKASSSSPYARMPSYRYRRRRSRSSSRSTEASPSRDVSPMGLKITGAIPMGELSMYTLS REPLKVTTAASYSPDQEASFLQVHDFFQQDLKEGFHVSMLNRRTTPV",CACNG4,Neuronal voltage-gated calcium channel gamma-4 subunit,327,36579,9.35,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated calcium channel activity Function: structural molecule activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane Component: plasma membrane Component: cell junction Component: intercellular junction Component: tight junction","",PF00822:PMP22_Claudin,HGNC:1408,Membrane,,"","",None,"10-30 108-128 137-157 187-207",Non Essential,"",CACNG4,CACNG4,BC034532,Chromosome:17,17q24 463,Two pore calcium channel protein 1,2009-05-14 20:05:11 UTC,2009-06-30 03:51:47 UTC,Q9ULQ1,May function as one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane (By similarity),"",">Two pore calcium channel protein 1 MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMN YQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVH ATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTA NFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLI SQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVEL FLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKN QDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSL KMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT",TPCN1,Voltage-dependent calcium channel protein TPC1,816,94148,8.39,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00520:Ion_trans,HGNC:18182,Membrane,,"","",None,"113-133 135-155 178-198 235-255 270-290 298-318 445-465 480-500 504-526 574-594 633-653 671-691",Non Essential,"",TPCN1,TPCN1,AK075071,Chromosome:12,12q24.13 464,Transient receptor potential cation channel subfamily V member 5,2009-05-14 20:06:38 UTC,2009-06-30 03:51:43 UTC,Q9NQA5,Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity),"",">Transient receptor potential cation channel subfamily V member 5 MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTC DVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRR ASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKT FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDL TEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYR PLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDL MRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNF AFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFGLGDRWF LRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRG WEILRQNTLGHLNLGLNLSEGDGEEVYHF",TRPV5,TrpV5; Osm-9-like TRP channel 3; OTRPC3; Epithelial calcium channel 1; ECaC1; ECaC; Calcium transport protein 2; CaT2,729,82552,6.43,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans",HGNC:3145,Apical cell membrane,,"","",None,"329-349 388-408 420-440 449-469 493-513 557-577",Non Essential,"",TRPV5,TRPV5,AY206695,"","" 465,Voltage-dependent calcium channel gamma-like subunit,2009-05-14 20:08:42 UTC,2009-06-30 03:51:45 UTC,Q8WXS4,Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity),"",">Voltage-dependent calcium channel gamma-like subunit MTAVGVHAQRPLGQRQPRRSFFESFIRTLIITCVALAVVLSSVSICDGHWLLAEDRLFGLWHFCTTTNQS VPICFRDLGQAHVPGLAVGMGLVRSVGALAVVAAIFGLEFLMVSQLCEDKHSQCKWVMGSILLLVSFVLS SGGLLGFVILLRNQVTLIGFTLMFWCEFTASFLLFLNAISGLHINSITHPWE",TMEM37,Neuronal voltage-gated calcium channel gamma-like subunit; Transmembrane protein 37,192,21123,7.81,">>> Function: Not Available || >>> Process: Not Available || >>> Component: cell Component: membrane","","",HGNC:18216,Membrane,,"","",None,"25-45 96-116 131-151 155-175",Non Essential,"",TMEM37,TMEM37,AF361356,"","" 466,Transient receptor potential cation channel subfamily M member 4,2009-05-14 20:12:49 UTC,2009-06-30 03:51:39 UTC,Q8TD43,"Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload","",">Transient receptor potential cation channel subfamily M member 4 MVVPEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTVWDSDAHTTEK PTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRR GLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPAR YRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDG DEKMLTRIENATQAQLPCLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQ VERIMTRKELLTVYSSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQW RSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQASHSAGTKAPA LKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKATSPLSLDAGLGQAPWS DLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAEEAARRKDLAFKFEGMGVDLFGEC YRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCP PLIYTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLR RWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSL ASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIF TVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQ EDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKV QGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERK LLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVA EALSRSALLPPGGPPPPDLPGSKD",TRPM4,Long transient receptor potential channel 4; LTrpC4; hTRPM4; Melastatin-4; Calcium-activated non-selective cation channel 1,1214,134303,8.20,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00520:Ion_trans,HGNC:17993,Cell membrane,,"","",None,"684-704 777-797 869-889 893-913 930-950 1020-1040",Non Essential,"",TRPM4,TRPM4,AK000048,Chromosome:19,19q13.33 467,Short transient receptor potential channel 3,2009-05-14 20:13:25 UTC,2009-06-30 03:51:40 UTC,Q13507,"Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion","",">Short transient receptor potential channel 3 MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCV DYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQ ELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDS EEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKC LVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVT DYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLA FLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPAN ESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSE VTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDG KTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILN QPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKL NPSMLRCE",TRPC3,TrpC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3,848,97356,6.74,">>> Function: cation channel activity Function: calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans PF08344:TRP_2",HGNC:12335,Membrane,,"","",None,"350-370 382-402 431-451 464-484 536-556 580-600 616-636 650-670 707-726",Non Essential,"",TRPC3,TRPC3,X89068,"","" 468,Short transient receptor potential channel 6,2009-05-14 20:13:46 UTC,2009-06-30 03:51:37 UTC,Q9Y210,"Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion","",">Short transient receptor potential channel 6 MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQT VLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLA VANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYD EDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGL ASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDV ETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSC FSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDA NDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRT VKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFI ENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSP KSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLA ELIRELGEKLSMEPNQEETNR",TRPC6,TrpC6,931,106328,6.64,">>> Function: cation channel activity Function: calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans PF08344:TRP_2",HGNC:12338,Membrane,,"","",None,"439-459 488-508 522-542 593-613 637-657 707-727",Non Essential,"",TRPC6,TRPC6,AJ007018,Chromosome:11,11q21-q22 469,Transient receptor potential cation channel subfamily M member 2,2009-05-14 20:14:15 UTC,2009-06-30 03:51:47 UTC,O94759,"Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity","",">Transient receptor potential cation channel subfamily M member 2 MEPSALRKAGSEQEEGFEGLPRRVTDLGMVSNLRRSNSSLFKSWRLQCPFGNNDKQESLSSWIPENIKKK ECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDPKKHVQEMPTDAFGDIVFTGLSQKVK KYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGS HTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTCLDSN HSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPC VVVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFR EGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTA ALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPRLQMHH VAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAI VQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEER AQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGL ISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLV CEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRL MHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFG QIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNY TFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAA LLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTAQA LHWIVRTLRASGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDSYHVNARHLLYPNCPVTRFPVPNE KVPWETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSFHGPYTVQAGLPLNPMGR TGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLEVLVVKLPLSEHWALPGGSREPGEMLPR KLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWIETVAVSVHFQDQNDVELNRLNSNLHACDSG ASIRWQVVDRRIPLYANHKTLLQKAAAEFGAHY",TRPM2,Long transient receptor potential channel 2; LTrpC-2; LTrpC2; Transient receptor potential channel 7; TrpC7; Estrogen-responsive element-associated gene 1 protein,1503,171200,7.53,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00520:Ion_trans,HGNC:12339,Membrane,,"","",None,"753-773 796-816 873-893 897-917 937-957 1026-1046",Non Essential,"",TRPM2,TRPM2,AB017549,Chromosome:21,21q22.3 470,Transient receptor potential cation channel subfamily V member 1,2009-05-14 20:14:43 UTC,2009-06-30 03:51:35 UTC,Q8NER1,"Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL","",">Transient receptor potential cation channel subfamily V member 1 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGEL DSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKS KKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAI ERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISA RDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL AYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFF RGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQ QMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNS LYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKL QRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGV KRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK",TRPV1,TrpV1; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1; Capsaicin receptor,839,94939,7.26,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans",HGNC:12716,Cell membrane,,"","",None,"434-454 477-497 514-534 536-556 580-600 660-680",Non Essential,"",TRPV1,TRPV1,AL136801,Chromosome:17,17p13.3 471,Transient receptor potential cation channel subfamily V member 2,2009-05-14 20:15:01 UTC,2009-06-30 03:51:50 UTC,Q9Y5S1,"Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH","",">Transient receptor potential cation channel subfamily V member 2 MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNYRKGTGASQPD PNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQ IDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGE LPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARL CPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCE ENSVLEIIAFHCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAA PHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVLCFL AIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEA WRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYV LLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDE RWCFRVEEVNWASWEQTLPTLCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN",TRPV2,TrpV2; Osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1,764,85982,5.64,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans",HGNC:18082,Cell membrane,,"","",None,"391-411 435-455 472-492 494-514 538-558 622-642",Non Essential,"",TRPV2,TRPV2,BC051305,Chromosome:17,17p11.2 472,Short transient receptor potential channel 1,2009-05-14 20:15:26 UTC,2009-06-30 03:51:40 UTC,P48995,Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion,"",">Short transient receptor potential channel 1 MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEEN SSGDLNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRP TIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHS RFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSR ELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKK IMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPAL ERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWD AFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYD KGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYN VVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSK WICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSK FRNEIRDLLGFRTSKYAMFYPRN",TRPC1,TrpC1; Transient receptor protein 1; TRP-1,793,91213,8.13,">>> Function: cation channel activity Function: calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00520:Ion_trans PF08344:TRP_2",HGNC:12333,Membrane,,"","",None,"387-407 416-436 458-475 540-560 587-607 617-637",Non Essential,"",TRPC1,TRPC1,Z73903,"","" 473,Transient receptor potential cation channel subfamily V member 4,2009-05-14 20:15:43 UTC,2009-06-30 03:51:40 UTC,Q9HBA0,"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism","",">Transient receptor potential cation channel subfamily V member 4 MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGPGDGRPNLRMK FQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDNKRWRKKIIEKQPQSPKAPAP QPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTI PVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGG YFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLL LKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYD LSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAY YQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLV IVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYAS ALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLV TYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDG TPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL",TRPV4,TrpV4; Osm-9-like TRP channel 4; OTRPC4; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; VRL-2; Vanilloid receptor-related osmotically-activated channel; VR-OAC; Transient receptor potential protein 12; TRP12,871,98282,7.84,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans",HGNC:18083,Isoform 5:Cell membrane,,"","",None,"466-486 509-529 551-571 573-593 617-637 691-711",Non Essential,"",TRPV4,TRPV4,AF279673,Chromosome:12,12q24.1 474,Short transient receptor potential channel 4,2009-05-14 20:15:59 UTC,2009-06-30 03:51:39 UTC,Q9UBN4,Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion,"",">Short transient receptor potential channel 4 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLG RTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFT PDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIA LSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEE QSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIA PKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSL RLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNA FSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADH ADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNL RRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKE SSNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVT DIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVD HRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL",TRPC4,TrpC4; Trp-related protein 4; hTrp-4; hTrp4,977,112102,7.83,">>> Function: cation channel activity Function: calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans PF08344:TRP_2",HGNC:12336,Membrane,,"","",None,"330-350 363-383 437-457 470-490 512-532 600-620",Non Essential,"",TRPC4,TRPC4,U40983,Chromosome:13,13q13.1-q13.2 475,Transient receptor potential cation channel subfamily M member 1,2009-05-14 20:16:17 UTC,2009-06-30 03:51:43 UTC,Q7Z4N2,"Calcium channel which may play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. Mediates cation influx in HEK293 cells","",">Transient receptor potential cation channel subfamily M member 1 MKDSNRCCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLEFQGGGYSNKA MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGV STGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFI LADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICD GSGRASDILSFAHKYCEEGGIINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSE GQQDIEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPP MATTKGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLLIENGVNMQHF LTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNN LFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVF LWQRGEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLT YELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYD DFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLG YLLLFNYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTF MIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSF GVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAW LTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYII IMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVE NMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNALENLAGIDRSDLIQARSRASSECEATYLLR QSSINSADGYSLYRYHFNGEELLFEDTSLSTSPGTGVRKKTCSFRIKEEKDVKTHLVPECQNSLHLSLGT STSATPDGSHLAVDDLKNAEESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNTQL TVETTNIEGTISYPLEETKITRYFPDETINACKTMKSRSFVYSRGRKLVGGVNQDVEYSSITDQQLTTEW QCQVQKITRSHSTDIPYIVSEAAVQAEHKEQFADMQDEHHVAEAIPRIPRLSLTITDRNGMENLLSVKPD QTLGFPSLRSKSLHGHPRNVKSIQGKLDRSGHASSVSSLVIVSGMTAEEKKVKKEKASTETEC",TRPM1,Long transient receptor potential channel 1; LTrpC1; Melastatin-1,1603,182181,6.82,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00520:Ion_trans,HGNC:7146,Cell membrane,,"","",None,"525-545 746-766 831-851 853-873 898-918 929-949 962-982 1055-1075 1106-1126",Non Essential,"",TRPM1,TRPM1,CH471216,Chromosome:15,15q13-q14 476,Transient receptor potential cation channel subfamily M member 3,2009-05-14 20:16:36 UTC,2009-06-30 03:51:40 UTC,Q9HCF6,"Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation","",">Transient receptor potential cation channel subfamily M member 3 MPEPWGTVYFLGIAQVFSFLFSWWNLEGVMNQADAPRPLNWTIRKLCHAAFLPSVRLLKAQKSWIERAFY KRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFG TIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKA AMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMS KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDSRLFYSFWGSCQLDSVG IGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLV TIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWN RVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTL YHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIP LRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKA MAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHR DFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLM LFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVG MILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVA RQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMAC YLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRW RKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEV NEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQE GNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRATSSHSVAK EPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAY ATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEA PIVKSHSFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPE REAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFS ISDKLDRQRNTASLQNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQSFESKHN",TRPM3,Long transient receptor potential channel 3; LTrpC3; Melastatin-2; MLSN2,1732,197545,7.11,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00520:Ion_trans,HGNC:17992,Membrane,,"","",None,"4-24 795-815 898-918 965-985 996-1016 1029-1049 1117-1137",Non Essential,"",TRPM3,TRPM3,AB046836,"","" 477,Transient receptor potential cation channel subfamily M member 5,2009-05-14 20:17:02 UTC,2009-06-30 03:51:45 UTC,Q9NZQ8,"Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage- dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals","",">Transient receptor potential cation channel subfamily M member 5 MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVS LVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMA SLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISE QRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEK QFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLD ELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYR SVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDR RRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSH LETEAEAARATREAKYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQ AFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRV EELVEAPRAQGDRGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVT LYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAM DFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVL YRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSY TFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQK VVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVA DVLAQGGGPRSSQHCGEGSQLVAADHRGGLDGWEQPGAGQPPSDT",TRPM5,Long transient receptor potential channel 5; LTrpC5; MLSN1- and TRP-related gene 1 protein,1165,131453,6.76,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00520:Ion_trans,HGNC:14323,Cell membrane,,"","",None,"734-754 812-832 836-856 873-893 955-975",Non Essential,"",TRPM5,TRPM5,AJ270996,Chromosome:11,11p15.5 478,Transient receptor potential cation channel subfamily M member 8,2009-05-14 20:17:24 UTC,2009-06-30 03:51:50 UTC,Q7Z2W7,"Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing","",">Transient receptor potential cation channel subfamily M member 8 MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKDSKATENVCKC GYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLK TPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIV AIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQ LEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALT SSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSE QDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTH DVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDRNGRDEMDIELHDVSPITRHP LQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFT ECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLF IIPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELV LYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLA MFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFG YTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDN ETLAWEGVMKENYLVKINTKANDTSEEMRHRFRQLDTKLNDLKGLLKEIANKIK",TRPM8,Long transient receptor potential channel 6; LTrpC6; Transient receptor potential-p8; Trp-p8,1104,127686,7.25,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00520:Ion_trans,HGNC:17961,Membrane,,"","",None,"692-712 735-755 760-780 795-815 830-850 959-979",Non Essential,"",TRPM8,TRPM8,AB061779,"","" 480,Transient receptor potential cation channel subfamily V member 3,2009-05-14 20:19:26 UTC,2009-06-30 03:51:50 UTC,Q8NET8,Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity,"",">Transient receptor potential cation channel subfamily V member 3 MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDS NIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLV ELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTE EAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQL LMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAK MGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFV LIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWA NMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVL ELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTI LEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRN NSKTTLNAFEEVEEFPETSV",TRPV3,TrpV3; Vanilloid receptor-like 3; VRL-3,790,90637,6.56,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans",HGNC:18084,Membrane,,"","",None,"440-460 488-508 524-544 546-566 590-610 650-670",Non Essential,"",TRPV3,TRPV3,AY118268,Chromosome:17,17p13.3 481,Short transient receptor potential channel 7,2009-05-14 20:19:49 UTC,2009-06-30 03:51:40 UTC,Q9HCX4,Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion,"",">Short transient receptor potential channel 7 MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLN FNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLS PLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKD SFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDL CRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAV KFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNET FTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARF MAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILP ANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGL SEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFD EGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTA NNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQ LSEKFGKNLNKDHLRVNKGKDI",TRPC7,TrpC7; TRP7 protein,862,99563,7.98,">>> Function: cation channel activity Function: calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans PF08344:TRP_2",HGNC:20754,Membrane,,"","",None,"352-372 384-404 466-486 538-558 582-602 652-672",Non Essential,"",TRPC7,TRPC7,AJ272034,"","" 482,Transient receptor potential cation channel subfamily M member 6,2009-05-14 20:20:12 UTC,2009-06-30 03:51:47 UTC,Q9BX84,Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region,"",">Transient receptor potential cation channel subfamily M member 6 MKEQPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSWTI SAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKMELPKLVI SVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPW GVIENQRDLIGKDVVCLYQTLDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHC RSRQGVPVVGLVVEGGPNVILSVWETVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICM IQNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDR VDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLL HHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAE STLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQH GEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELR NWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSH VPQSQDFQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIV KFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYW NLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYI VIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQPSCPPGSFLTPFLQ AVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCC HRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEM NEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTCKKLPHSWSNVICAE VLGSMEIAGEKKYQYYSMPSSLLRSLAGGRHPPRVQRGALLEITNSKREATNVRNDQERQETQSSIVVSG VSPNRQAHSKYGQFLLVPSNLKRVPFSAETVLPLSRPSVPDVLATEQDIQTEVLVHLTGQTPVVSDWASV DEPKEKHEPIAHLLDGQDKAEQVLPTLSCTPEPMTMSSPLSQAKIMQTGGGYVNWAFSEGDETGVFSIKK KWQTCLPSTCDSDSSRSEQHQKQAQDSSLSDNSTRSAQSSECSEVGPWLQPNTSFWINPLRRYRPFARSH SFRFHKEEKLMKICKIKNLSGSSEIGQGAWVKAKMLTKDRRLSKKKKNTQGLQVPIITVNACSQSDQLNP EPGENSISEEEYSKNWFTVSKFSHTGVEPYIHQKMKTKEIGQCAIQISDYLKQSQEDLSKNSLWNSRSTN LNRNSLLKSSIGVDKISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITVYRLEESSPLN LDKSMSSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQVFIVKSFLPEVVRTWHKIFQE STVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVFLIYCHSANQWLTIEKYMTGEFRKYNNNN GDEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEVKQSRGMVFGPANLGEDAIR NFIAKHHCNSCCRKLKLPDLKRNDYSPERINSTFGLEIKIESAEEPPARETGRNSPEDDMQL",TRPM6,Channel kinase 2; Melastatin-related TRP cation channel 6,2022,231710,7.82,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF02816:Alpha_kinase PF00520:Ion_trans",HGNC:17995,Membrane,,"","",None,"742-762 842-862 906-926 940-960 973-993 1048-1068",Non Essential,"",TRPM6,TRPM6,AL354795,"","" 483,Transient receptor potential cation channel subfamily M member 7,2009-05-14 20:20:27 UTC,2009-06-30 03:51:49 UTC,Q96QT4,Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1),"",">Transient receptor potential cation channel subfamily M member 7 MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDVKLGDH FNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVH GGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVI ENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIG QGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTI KKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRV DIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLF HLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRK SHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWAC LMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQ DETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPA ILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAG KVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFL AVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYA YEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIM AYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFH SGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKV HNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIF GQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTK FFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDLQRFKETSNKIKILSNNNTSEN TLKRVSSLAGFTDCHRTSIPVHSKQAEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNG LTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAK IEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRA AQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLA FSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLK LPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNSVRLML",TRPM7,Long transient receptor potential channel 7; LTrpC7; Channel-kinase 1,1865,212700,7.95,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF02816:Alpha_kinase PF00520:Ion_trans",HGNC:17994,Membrane,,"","",None,"756-776 856-876 919-939 963-983 996-1016 1075-1095",Non Essential,1IAJ,TRPM7,TRPM7,BC051024,Chromosome:15,15q21 484,Putative short transient receptor potential channel 2-like protein,2009-05-14 20:21:00 UTC,2009-06-30 03:51:47 UTC,Q6ZNB5,"","",">Putative short transient receptor potential channel 2-like protein MAPVKISHVVSFSSQDPKYPVENLLNPDSPRRPWLGCPQDKSGQLKVELQLERAVPTGYIDVGNCGCAFL QIDVGHSSWPLDRPFITLLPATTLMSLTDSKQGKNRSGVRMFKDGKEGKSRKDGGGLYEKQRCSTKEDCE CY","",TrpC2-like protein,142,15763,8.37,">>> Function: binding Function: nucleic acid binding Function: DNA binding Function: damaged DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA repair Process: single strand break repair || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","",PF01834:XRCC1_N,"",Cytoplasmic,,"","",None,None,Non Essential,"","","",AK131288,"","" 485,Short transient receptor potential channel 5,2009-05-14 20:21:26 UTC,2009-06-30 03:51:47 UTC,Q9UL62,Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion,"",">Short transient receptor potential channel 5 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLG RSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFT PDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIA LSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELD PQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLI SPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSS LRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEK QNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQL IADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFT ERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSF STSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGP SLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQ GAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL",TRPC5,TrpC5; Htrp-5; Htrp5,973,111413,7.31,">>> Function: cation channel activity Function: calcium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00023:Ank PF00520:Ion_trans PF08344:TRP_2",HGNC:12337,Membrane,,"","",None,"331-351 399-419 438-458 471-491 513-533 604-624",Non Essential,"",TRPC5,TRPC5,AL049563,"","" 486,Histone H1.0,2009-05-14 21:06:06 UTC,2009-06-30 03:51:36 UTC,P07305,Histones H1 are necessary for the condensation of nucleosome chains into higher order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division,"",">Histone H1.0 MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKL SIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATPKKASKPKKAASKAPTKKPKA TPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVKPKAKSSAKRAGKKK",H1F0,Histone H1(0); Histone H1',194,20863,11.60,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Cell wall/membrane/envelope biogenesis,PF00538:Linker_histone,HGNC:4714,Nucleus,,"","",None,None,Non Essential,"",H1F0,H1F0,BC029046,Chromosome:22,22q13.1 487,Histone H1.2,2009-05-14 21:06:25 UTC,2009-06-30 03:51:38 UTC,P16403,Histones H1 are necessary for the condensation of nucleosome chains into higher order structures,"",">Histone H1.2 MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAG YDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKVKKAGGTKPKKPVGAAKKPKK AAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVAKPKKAAKSAAKAVKPKAAKPKVVKPKKAAP KKK",HIST1H1C,Histone H1d,213,21365,11.71,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Lipid transport and metabolism,PF00538:Linker_histone,HGNC:4716,Nucleus,,"","",None,None,Non Essential,1GHC,HIST1H1C,HIST1H1C,BC002649,"","" 488,Histone H1.4,2009-05-14 21:06:44 UTC,2009-06-30 03:51:38 UTC,P10412,Histones H1 are necessary for the condensation of nucleosome chains into higher order structures,"",">Histone H1.4 MSETAPAAPAAPAPAEKTPVKKKARKSAGAAKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAG YDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGAAKKPKK ATGAATPKKSAKKTPKKAKKPAAAAGAKKAKSPKKAKAAKPKKAPKSPAKAKAVKPKAAKPKTAKPKAAK PKKAAAKKK",HIST1H1E,Histone H1b,219,21865,11.80,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Lipid transport and metabolism,PF00538:Linker_histone,HGNC:4718,Nucleus,,"","",None,None,Non Essential,1GHC,HIST1H1E,HIST1H1E,BC099632,"","" 489,Histone H1.5,2009-05-14 21:07:24 UTC,2009-06-30 03:51:43 UTC,P16401,Histones H1 are necessary for the condensation of nucleosome chains into higher order structures,"",">Histone H1.5 MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGLSLAALKKALA AGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGATPK KAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKAKAAAKPKKATKSPAKPKAVKPKAAKPKAAKPKA AKPKAAKAKKAAAKKK",HIST1H1B,Histone H1a,226,22580,11.69,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Lipid transport and metabolism,PF00538:Linker_histone,HGNC:4719,Nucleus,,"","",None,None,Non Essential,1GHC,HIST1H1B,HIST1H1B,BC101583,"","" 490,Histone H1.3,2009-05-14 21:07:35 UTC,2009-06-30 03:51:47 UTC,P16402,Histones H1 are necessary for the condensation of nucleosome chains into higher order structures,"",">Histone H1.3 MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAA GYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPK KVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKV TKAKKAAPKKK",HIST1H1D,Histone H1c,221,22350,11.79,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Lipid transport and metabolism,PF00538:Linker_histone,HGNC:4717,Nucleus,,"","",None,None,Non Essential,1GHC,HIST1H1D,HIST1H1D,BC111971,"","" 491,Histone H1t,2009-05-14 21:08:07 UTC,2009-06-30 03:51:49 UTC,P22492,Histones H1 are necessary for the condensation of nucleosome chains into higher order structures,"",">Histone H1t MSETVPAASASAGVAAMEKLPTKKRGRKPAGLISASRKVPNLSVSKLITEALSVSQERVGMSLVALKKAL AAAGYDVEKNNSRIKLSLKSLVNKGILVQTRGTGASGSFKLSKKVIPKSTRSKAKKSVSAKTKKLVLSRD SKSPKTAKTNKRAKKPRATTPKTVRSGRKAKGAKGKQQQKSPVKARASKSKLTQHHEVNVRKATSKK",HIST1H1T,Testicular H1 histone,207,22019,12.28,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00538:Linker_histone,HGNC:4720,Nucleus,,"","",None,None,Non Essential,"",HIST1H1T,HIST1H1T,BC069517,"","" 492,Histone H1x,2009-05-14 21:08:23 UTC,2009-06-30 03:51:39 UTC,Q92522,Histones H1 are necessary for the condensation of nucleosome chains into higher order structures,"",">Histone H1x MSVELEEALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQPGKYSQLVVETIRRLGERNGSSLAKI YTEAKKVPWFDQQNGRTYLKYSIKALVQNDTLLQVKGTGANGSFKLNRKKLEGGGERRGAPAAATAPAPT AHKAKKAAPGAAGSRRADKKPARGQKPEQRSHKKGAGAKKDKGGKAKKTAAAGGKKVKKAAKPSVPKVPK GRK",H1FX,"",213,22487,11.49,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00538:Linker_histone,HGNC:4722,Nucleus,,"","",None,None,Non Essential,"",H1FX,H1FX,BC010435,"","" 493,Histone H1.1,2009-05-14 21:08:52 UTC,2009-06-30 03:51:46 UTC,Q02539,Histones H1 are necessary for the condensation of nucleosome chains into higher order structures,"",">Histone H1.1 MSETVPPAPAASAAPEKPLAGKKAKKPAKAAAASKKKPAGPSVSELIVQAASSSKERGGVSLAALKKALA AAGYDVEKNNSRIKLGIKSLVSKGTLVQTKGTGASGSFKLNKKASSVETKPGASKVATKTKATGASKKLK KATGASKKSVKTPKKAKKPAATRKSSKNPKKPKTVKPKKVAKSPAKAKAVKPKAAKARVTKPKTAKPKKA APKKK",HIST1H1A,"",215,21842,11.76,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Lipid transport and metabolism,PF00538:Linker_histone,HGNC:4715,Nucleus,,"","",None,None,Non Essential,"",HIST1H1A,HIST1H1A,BC112140,"","" 494,Testis-specific H1 histone,2009-05-14 21:09:37 UTC,2009-06-30 03:51:36 UTC,Q75WM6,"Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone- protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity)","",">Testis-specific H1 histone MEQALTGEAQSRWPRRGGSGAMAEAPGPSGESRGHSATQLPAEKTVGGPSRGCSSSVLRVSQLVLQAIST HKGLTLAALKKELRNAGYEVRRKSGRHEAPRGQAKATLLRVSGSDAAGYFRVWKVPKPRRKPGRARQEEG TRAPWRTPAAPRSSRRRRQPLRKAARKAREVWRRNARAKAKANARARRTRRARPRAKEPPCARAKEEAGA TAADEGRGQAVKEDTTPRSGKDKRRSSKPREEKQEPKKPAQRTIQ",H1FNT,Haploid germ cell-specific nuclear protein 1; Histone H1t2,255,28116,12.29,"","","",HGNC:24893,Nucleus (By similarity),,"","",None,None,Non Essential,"",H1FNT,H1FNT,AY496854,Chromosome:12,12q13.11 495,Histone H1oo,2009-05-14 21:10:10 UTC,2009-06-30 03:51:44 UTC,Q8IZA3,"May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity)","",">Histone H1oo MAPGSVTSDISPSSTSTAGSSRSPESEKPGPSHGGVPPGGPSHSSLPVGRRHPPVLRMVLEALQAGEQRR GTSVAAIKLYILHKYPTVDVLRFKYLLKQALATGMRRGLLARPLNSKARGATGSFKLVPKHKKKIQPRKM APATAPRRAGEAKGKGPKKPSEAKEDPPNVGKVKKAAKRPAKVQKPPPKPGAATEKARKQGGAAKDTRAQ SGEARKVPPKPDKAMRAPSSAGGLSRKAKAKGSRSSQGDAEAYRKTKAESKSSKPTASKVKNGAASPTKK KVVAKAKAPKAGQGPNTKAAAPAKGSGSKVVPAHLSRKTEAPKGPRKAGLPIKASSSKVSSQRAEA",H1FOO,Oocyte-specific histone H1; Oocyte-specific linker histone H1; osH1,346,35814,11.90,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Lipid transport and metabolism,PF00538:Linker_histone,HGNC:18463,Cytoplasm (By similarity). Nucleus (By similarity),,"","",None,None,Non Essential,"",H1FOO,H1FOO,BC047943,"","" 496,Histone H2A type 1-B/E,2009-05-14 21:13:16 UTC,2009-06-30 03:51:34 UTC,P04908,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 1-B/E MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK",HIST1H2AB,H2A/m; H2A.2; H2A/a,130,14136,11.66,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4734,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2AB,HIST1H2AB,BC093862,"","" 497,Histone H2A type 1-C,2009-05-14 21:13:45 UTC,2009-06-30 03:51:38 UTC,Q93077,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 1-C MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK",HIST1H2AC,H2A/l,130,14106,11.66,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4733,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2AC,HIST1H2AC,BC085010,"","" 498,Histone H2A type 1-D,2009-05-14 21:15:08 UTC,2009-06-30 03:51:44 UTC,P20671,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 1-D MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK",HIST1H2AD,H2A.3; H2A/g,130,14108,11.55,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4729,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2AD,HIST1H2AD,BC128035,"","" 499,Histone H2A type 1-J,2009-05-14 21:15:35 UTC,2009-06-30 03:51:48 UTC,Q99878,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 1-J MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKTK",HIST1H2AJ,H2A/e,128,13937,11.53,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4727,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2AJ,HIST1H2AJ,BC066237,"","" 500,Histone H2A type 1,2009-05-14 21:15:52 UTC,2009-06-30 03:51:50 UTC,P0C0S8,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 1 MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK",HIST1H2AG,H2A.1; H2A/p,130,14092,11.55,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4737,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2AG,HIST1H2AG,BC112256,"","" 501,Histone H2A type 2-A,2009-05-14 21:16:17 UTC,2009-06-30 03:51:45 UTC,Q6FI13,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 2-A MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK",HIST2H2AA3,H2A.2; H2A/o,130,14096,11.55,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4736,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST2H2AA3,HIST2H2AA3,BC098171,"","" 502,Histone H2A type 2-C,2009-05-14 21:16:44 UTC,2009-06-30 03:51:48 UTC,Q16777,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 2-C MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHKAKSK",HIST2H2AC,H2A-GL101; H2A/q,129,13989,11.55,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4738,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST2H2AC,HIST2H2AC,X57985,"","" 503,Histone H2A.x,2009-05-14 21:17:10 UTC,2009-06-30 03:51:34 UTC,P16104,"Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation","",">Histone H2A.x MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTSATVGPKAPSGGKKATQAS QEY",H2AFX,H2a/x,143,15145,11.39,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4739,Nucleus,,"","",None,None,Non Essential,1EQZ,H2AFX,H2AFX,BC013416,Chromosome:11,11q23.2-q23.3 504,Histone H2A type 1-A,2009-05-14 21:17:37 UTC,2009-06-30 03:51:34 UTC,Q96QV6,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 1-A MSGRGKQGGKARAKSKSRSSRAGLQFPVGRIHRLLRKGNYAERIGAGAPVYLAAVLEYLTAEILELAGNA SRDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTESHHHKAQSK",HIST1H2AA,H2A/r,131,14234,11.50,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:18729,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2AA,HIST1H2AA,BC062211,"","" 505,Histone H2A type 1-H,2009-05-14 21:17:56 UTC,2009-06-30 03:51:42 UTC,Q96KK5,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 1-H MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAK",HIST1H2AH,H2A/s,128,13906,11.53,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:13671,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2AH,HIST1H2AH,BC093849,"","" 506,Histone H2A type 2-B,2009-05-14 21:18:15 UTC,2009-06-30 03:51:38 UTC,Q8IUE6,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 2-B MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTESHKPGKNK",HIST2H2AB,"",130,13996,11.53,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:20508,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST2H2AB,HIST2H2AB,AL591493,"","" 507,Histone H2A type 3,2009-05-14 21:18:34 UTC,2009-06-30 03:51:36 UTC,Q7L7L0,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A type 3 MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK",HIST3H2A,"",130,14122,11.66,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:20507,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST3H2A,HIST3H2A,BC082269,"","" 508,Histone H2A.Z,2009-05-14 21:18:56 UTC,2009-06-30 03:51:43 UTC,P0C0S5,"Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division","",">Histone H2A.Z MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELA GNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV",H2AFZ,H2A/z,128,13553,11.29,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4741,Nucleus,,"","",None,None,Non Essential,1F66,H2AFZ,H2AFZ,BC103743,"","" 509,Histone H2A-Bbd type 2/3,2009-05-14 21:19:22 UTC,2009-06-30 03:51:42 UTC,P0C5Z0,"Atypical histone H2A which can replace conventional H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Nucleosomes containing this histone are less rigid and organize only 118 base pair of DNA instead of 147 in classical nucleosomes. They are associated with transcriptionally active chromatin and excluded form Barr bodies","",">Histone H2A-Bbd type 2/3 MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVIEYLTAKVLEL AGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQVAPGED",H2AFB2,H2A Barr body-deficient; H2A.Bbd,115,12714,11.10,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:18298,Nucleus,,"","",None,None,Non Essential,"",H2AFB2,H2AFB2,BC101418,"","" 510,Histone H2A-Bbd type 1,2009-05-14 21:19:38 UTC,2009-06-30 03:51:39 UTC,P0C5Y9,"Atypical histone H2A which can replace conventional H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Nucleosomes containing this histone are less rigid and organize only 118 base pair of DNA instead of 147 in classical nucleosomes. They are associated with transcriptionally active chromatin and excluded form Barr bodies","",">Histone H2A-Bbd type 1 MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVIEYLTAKVPEL AGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQVAPGED",H2AFB1,H2A Barr body-deficient; H2A.Bbd,115,12698,11.10,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:22516,Nucleus,,"","",None,None,Non Essential,"",H2AFB1,H2AFB1,BX842559,"","" 511,Histone H2A.V,2009-05-14 21:20:01 UTC,2009-06-30 03:51:38 UTC,Q71UI9,"Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)","",">Histone H2A.V MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELA GNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTA",H2AFV,H2A.F/Z,128,13509,11.29,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:20664,Nucleus (By similarity),,"","",None,None,Non Essential,1F66,H2AFV,H2AFV,BC070169,"","" 512,Histone H2A.J,2009-05-14 21:21:01 UTC,2009-06-30 03:51:48 UTC,Q9BTM1,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2A.J MSGRGKQGGKVRAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNA ARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESQKTKSK",H2AFJ,H2a/j,129,14020,11.55,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:14456,Nucleus (By similarity),,"","",None,None,Non Essential,1EQZ,H2AFJ,H2AFJ,BC003602,Chromosome:12,12p12 513,Histone H2B type 1-C/E/F/G/I,2009-05-14 21:22:17 UTC,2009-06-30 03:51:42 UTC,P62807,"Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid","",">Histone H2B type 1-C/E/F/G/I MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSK",HIST1H2BC,H2B.a/g/h/k/l; H2B.1 A; H2B/a; H2B/g; H2B/h; H2B/k; H2B/l,125,13819,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4757,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2BC,HIST1H2BC,BC106899,"","" 514,Histone H2B type 1-D,2009-05-14 21:22:37 UTC,2009-06-30 03:51:47 UTC,P58876,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type 1-D MPEPTKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST1H2BD,H2B.b; H2B/b; H2B.1 B; HIRA-interacting protein 2,126,13936,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4747,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2BD,HIST1H2BD,BC002842,"","" 515,Histone H2B type 1-J,2009-05-14 21:22:59 UTC,2009-06-30 03:51:41 UTC,P06899,"Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid","",">Histone H2B type 1-J MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK",HIST1H2BJ,H2B.r; H2B/r; H2B.1,126,13904,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4761,Nucleus,,"","",None,None,Non Essential,1F66,HIST1H2BJ,HIST1H2BJ,AL021807,"","" 516,Histone H2B type 1-K,2009-05-14 21:23:15 UTC,2009-06-30 03:51:37 UTC,O60814,"Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid","",">Histone H2B type 1-K MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK",HIST1H2BK,H2B K; HIRA-interacting protein 1,126,13890,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:13954,Nucleus,,"","",None,None,Non Essential,1F66,HIST1H2BK,HIST1H2BK,BC108737,"","" 517,Histone H2B type 2-E,2009-05-14 21:23:35 UTC,2009-06-30 03:51:35 UTC,Q16778,"Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid","",">Histone H2B type 2-E MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST2H2BE,H2B.q; H2B/q; H2B-GL105,126,13920,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4760,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST2H2BE,HIST2H2BE,M60756,"","" 518,Histone H2B type 1-A,2009-05-14 21:23:58 UTC,2009-06-30 03:51:42 UTC,Q96A08,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type 1-A MPEVSSKGATISKKGFKKAVVKTQKKEGKKRKRTRKESYSIYIYKVLKQVHPDTGISSKAMSIMNSFVTD IFERIASEASRLAHYSKRSTISSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST1H2BA,"Histone H2B, testis; Testis-specific histone H2B",127,14168,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:18730,Nucleus,,"","",None,None,Non Essential,"",HIST1H2BA,HIST1H2BA,BC066243,"","" 519,Histone H2B type 1-B,2009-05-14 21:24:14 UTC,2009-06-30 03:51:38 UTC,P33778,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type 1-B MPEPSKSAPAPKKGSKKAITKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST1H2BB,H2B.f; H2B/f; H2B.1,126,13950,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4751,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2BB,HIST1H2BB,BC096728,"","" 520,Histone H2B type 1-H,2009-05-14 21:24:33 UTC,2009-06-30 03:51:49 UTC,Q93079,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type 1-H MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST1H2BH,H2B.j; H2B/j,126,13892,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4755,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2BH,HIST1H2BH,BC096119,"","" 521,Histone H2B type 1-L,2009-05-14 21:24:51 UTC,2009-06-30 03:51:43 UTC,Q99880,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type 1-L MPELAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIASEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST1H2BL,H2B.c; H2B/c,126,13952,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4748,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2BL,HIST1H2BL,BC093761,"","" 522,Histone H2B type 1-M,2009-05-14 21:25:15 UTC,2009-06-30 03:51:49 UTC,Q99879,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type 1-M MPEPVKSAPVPKKGSKKAINKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST1H2BM,H2B.e; H2B/e,126,13989,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4750,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2BM,HIST1H2BM,BC067489,"","" 523,Histone H2B type 1-N,2009-05-14 21:25:33 UTC,2009-06-30 03:51:36 UTC,Q99877,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type 1-N MPEPSKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST1H2BN,H2B.d; H2B/d,126,13922,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4749,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2BN,HIST1H2BN,BC101413,"","" 524,Histone H2B type 1-O,2009-05-14 21:25:49 UTC,2009-06-30 03:51:42 UTC,P23527,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type 1-O MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST1H2BO,H2B.n; H2B/n; H2B.2,126,13906,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4758,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H2BO,HIST1H2BO,BC106720,"","" 525,Histone H2B type 2-F,2009-05-14 21:26:08 UTC,2009-06-30 03:51:35 UTC,Q5QNW6,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type 2-F MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST2H2BF,"",126,13920,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:24700,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST2H2BF,HIST2H2BF,BC110793,"","" 526,Histone H2B type 3-B,2009-05-14 21:26:32 UTC,2009-06-30 03:51:36 UTC,Q8N257,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type 3-B MPDPSKSAPAPKKGSKKAVTKAQKKDGKKRKRGRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIASEASRLAHYNKRSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK",HIST3H2BB,H2B type 12,126,13908,11.00,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:20514,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST3H2BB,HIST3H2BB,BC100857,"","" 527,Histone H2B type F-S,2009-05-14 21:26:55 UTC,2009-06-30 03:51:37 UTC,P57053,"Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid","",">Histone H2B type F-S MPEPAKSAPAPKKGSKKAVTKAQKKDGRKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDI FERIAGEASRLPHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK",H2BFS,H2B.s; H2B/s,126,13944,11.05,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:4762,Nucleus,,"","",None,None,Non Essential,1F66,H2BFS,H2BFS,BC126339,Chromosome:21,21q22.3 528,Putative histone H2B type 2-C ,2009-05-14 21:27:16 UTC,2009-05-14 21:27:16 UTC,Q6DN03 ,"","","","","","","","","","","","","","",,,,,,,,,,, 529,Putative histone H2B type 2-D,2009-05-14 21:27:35 UTC,2009-06-30 03:51:43 UTC,Q6DRA6,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Putative histone H2B type 2-D MPEPAKFAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKRVHPDTGIWCKAMGIMNSFLNDI FERIAGEASRLAHYNKRSTITSRRSRRPCACCCPASWPSTPCPRAPRRSPSTPAPSESLPGPGARSLPPS LPPRVAGCFVSKGSFQGHLTPLVK",HIST2H2BD,"",164,18018,11.26,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:20517,Nucleus,,"","",None,None,Non Essential,"",HIST2H2BD,HIST2H2BD,AY648853,"","" 530,Histone H2B type W-T,2009-05-14 21:28:12 UTC,2009-06-30 03:51:37 UTC,Q7Z2G1,"Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function","",">Histone H2B type W-T MLRTEVPRLPRSTTAIVWSCHLMATASAMAGPSSETTSEEQLITQEPKEANSTTSQKQSKQRKRGRHGPR RCHSNCRGDSFATYFRRVLKQVHQGLSLSREAVSVMDSLVHDILDRIATEAGHLARSTKRQTITAWETRM AVRLLLPGQMGKLAESEGTKAVLRTSLYAIQQQRK",H2BFWT,H2B histone family member W testis-specific,175,19600,11.17,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:27252,Nucleus membrane,,"","",None,None,Non Essential,"",H2BFWT,H2BFWT,BC121816,"","" 531,Histone H2B type F-M,2009-05-14 21:28:31 UTC,2009-06-30 03:51:42 UTC,P0C1H6,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H2B type F-M MKCHAGSLSANLPALKVTGWSRCVASRQPITVGVCGPKRPLWPSSEKPFNFHTLAKLHDIGLGNDFLDMT LKAQQQKQKSHATIPKCPPLPWSPTVTLCSCYLMAAASAMAEASSETTSEEGQSIQEPKEANSTKAQKQK RRGCRGSRRRHANRRGDSFGDSFTPYFPRVLKQVHQGLSLSQEAVSVMDSMIHDILDRIATEAGQLAHYT KRVTITSRDIQMAVRLLLPGKMGKLAEAQGTNAALRTSLCAIWQQRK",H2BFM,H2B.s; H2B/s,257,28267,10.48,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00125:Histone,HGNC:27867,Nucleus,,"","",None,None,Non Essential,"",H2BFM,H2BFM,"","","" 532,Peroxisome proliferator-activated receptor gamma,2009-05-15 15:41:42 UTC,2009-06-30 03:51:39 UTC,P37231,"Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis","",">Peroxisome proliferator-activated receptor gamma MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDF SSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECR VCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRF GRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDM NSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETD MSLHPLLQEIYKDLY",PPARG,PPAR-gamma; Nuclear receptor subfamily 1 group C member 3,505,57621,5.77,">>> Function: steroid hormone receptor activity Function: transcription factor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:9236,Nucleus,,"","",None,None,Non Essential,1I7I,PPARG,PPARG,AY157024,"","" 533,Peroxisome proliferator-activated receptor delta,2009-05-15 15:42:03 UTC,2009-06-30 03:51:46 UTC,Q03181,"Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Decreases expression of NPC1L1 once activated by a ligand","",">Peroxisome proliferator-activated receptor delta MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSL NMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSH NAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAP FVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVT LLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLAL FIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI KKTETETSLHPLLQEIYKDMY",PPARD,PPAR-delta; PPAR-beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUC1; NUCI,441,49904,7.65,">>> Function: steroid hormone receptor activity Function: transcription factor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:9235,Nucleus,,"","",None,None,Non Essential,1Y0S,PPARD,PPARD,AB099507,"","" 534,"Nitric oxide synthase, brain",2009-05-15 16:16:53 UTC,2009-05-21 16:03:14 UTC,P29475,"","","","","",1424,"","","","","","","","",,,,,,,,,,, 535,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3,2009-05-15 23:16:12 UTC,2009-06-30 03:51:47 UTC,Q96Q83,"Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Has a strong preference for single-stranded DNA. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron","",">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPR VIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELP YTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFG ATRTFEMRKKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPD PRGAPW",ALKBH3,Alkylated DNA repair protein alkB homolog 3; Prostate cancer antigen 1; DEPC-1,286,33375,8.58,"","Replication, recombination and repair","",HGNC:30141,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",ALKBH3,ALKBH3,BC067257,Chromosome:11,11p11.2 536,JmjC domain-containing histone demethylation protein 3A,2009-05-15 23:18:41 UTC,2009-06-30 03:51:34 UTC,O75164,"Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively","",">JmjC domain-containing histone demethylation protein 3A MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAP IQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTL YEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYS VPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFN HGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEA AEFLKESELPPRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDL SSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEEQEAAALDLSV NPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTGVLTVHSYAKGDGRVTVGEPC TRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQ RTKPLIPEMCFTSTGCSTDINLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANA LEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRT AGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSITAGQKVISKHK NGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVAS HPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYR EDYIEPALYRAIME",JMJD2A,Jumonji domain-containing protein 2A,1064,120721,5.57,">>> Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: protein binding Function: binding Function: nucleic acid binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: Not Available","","PF02373:JmjC PF02375:JmjN PF00628:PHD",HGNC:22978,Nucleus,,"","",None,None,Non Essential,"",JMJD2A,JMJD2A,BC002558,"","" 537,Hypoxia-inducible factor 1-alpha inhibitor,2009-05-15 23:25:46 UTC,2009-06-30 03:51:43 UTC,Q9NWT6,"Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases","",">Hypoxia-inducible factor 1-alpha inhibitor MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLV YPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGG EERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQI KGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHH IESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN",HIF1AN,Hypoxia-inducible factor asparagine hydroxylase; Factor inhibiting HIF-1; FIH-1,349,40286,5.28,"","","",HGNC:17113,Nucleus (Potential),,"","",None,None,Non Essential,1H2N,HIF1AN,HIF1AN,AL359615,Chromosome:10,10q24 538,Egl nine homolog 3,2009-05-15 23:32:28 UTC,2009-06-30 03:51:37 UTC,Q9H6Z9,"Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism (By similarity)","",">Egl nine homolog 3 MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQLAGPRAGVSK RHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPN GDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTV WYFDAEERAEAKKKFRNLTRKTESALTED",EGLN3,Hypoxia-inducible factor prolyl hydroxylase 3; HIF-prolyl hydroxylase 3; HIF-PH3; HPH-1; Prolyl hydroxylase domain-containing protein 3; PHD3,239,27262,7.70,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF03171:2OG-FeII_Oxy,HGNC:14661,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",EGLN3,EGLN3,BC111057,Chromosome:14,14q13.1 539,Egl nine homolog 2,2009-05-15 23:35:34 UTC,2009-06-30 03:51:46 UTC,Q96KS0,"Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation","",">Egl nine homolog 2 MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATS TTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQE NQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGAALGGRVLAEV EALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRT KAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIF WSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT",EGLN2,Hypoxia-inducible factor prolyl hydroxylase 1; HIF-prolyl hydroxylase 1; HIF-PH1; HPH-3; Prolyl hydroxylase domain-containing protein 1; PHD1; Estrogen-induced tag 6,407,43651,7.97,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF03171:2OG-FeII_Oxy,HGNC:14660,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",EGLN2,EGLN2,BC036051,Chromosome:19,19q13.2 540,Egl nine homolog 1,2009-05-15 23:35:58 UTC,2009-06-30 03:51:48 UTC,Q9GZT9,"Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex","",">Egl nine homolog 1 MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVG PHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAA EAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVV DDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLI RHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGK AQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS VGKDVF",EGLN1,Hypoxia-inducible factor prolyl hydroxylase 2; HIF-prolyl hydroxylase 2; HIF-PH2; HPH-2; Prolyl hydroxylase domain-containing protein 2; PHD2; SM-20,426,46021,8.66,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones","PF03171:2OG-FeII_Oxy PF01753:zf-MYND",HGNC:1232,"",,"","",None,None,Non Essential,"",EGLN1,EGLN1,AL445524,"","" 541,JmjC domain-containing histone demethylation protein 2A,2009-05-16 00:36:26 UTC,2009-06-30 03:51:37 UTC,Q9Y4C1,"Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation","",">JmjC domain-containing histone demethylation protein 2A MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGE SWRKRRWIEVYSLLRRAFLVEHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRV FLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDESHLLKGDKNLVGSEVKIYSLDPSTQWFSAT VVNGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQAKSCS EASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCL NTKSEALRTKPDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTGLPKECLPT KASSKAELEIANPPELQKHLEHAPSPSDVSNAPEVKAGVNSDSPNNCSGKKVEPSALACRSQNLKESSVK VDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKEQ QKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAIGLWLPLTKNVVGIDLDTAKYILANIGDHFC QMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAA YKTFSWLKCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDL KQTSLAGEKPTLGAVLQQNPSVLEPAAVGGEAASKPAGSMKPACPASTSPLNWLADLTSGNVNKENKEKQ PTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDI FASLVQNKTTSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSG VHHKLNSELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNEKEPMVLKLKDWPP GEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLH LDVSDAANVMVYVGIPKGQCEQEEEVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLK KVSEEQGQENPADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKV AEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSFGKP",JMJD1A,Jumonji domain-containing protein 1A,1321,147328,8.15,"","",PF02373:JmjC,HGNC:20815,Nucleus (Probable),,"","",None,None,Non Essential,"",JMJD1A,JMJD1A,AC068288,"","" 542,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2,2009-05-16 00:48:24 UTC,2009-06-30 03:51:39 UTC,Q6NS38,"Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron","",">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYT VLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLER IRDHVSGVTGQTFNFVLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDSRGKSPSRR VAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRKILLTKK",ALKBH2,Alkylated DNA repair protein alkB homolog 2; Oxy DC1,261,29323,10.22,"","Replication, recombination and repair",PF03171:2OG-FeII_Oxy,HGNC:32487,Nucleus,,"","",None,None,Non Essential,"",ALKBH2,ALKBH2,BC070489,Chromosome:12,12q24.11 543,Glutathione S-transferase P,2009-05-19 05:03:53 UTC,2009-06-30 03:51:44 UTC,P09211,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles,"",">Glutathione S-transferase P MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTIL RHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGG KTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ",GSTP1,GST class-pi; GSTP1-1,210,23356,5.30,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:4638,"",,"","",None,None,Non Essential,13GS,GSTP1,GSTP1,BC010915,Chromosome:11,11q13 544,Protein disulfide-isomerase,2009-05-19 05:21:07 UTC,2009-06-30 03:51:42 UTC,P07237,"This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP","",">Protein disulfide-isomerase MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKL KAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTL PDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFD EGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAE SFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGK IKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENI VIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEA EEPDMEEDDDQKAVKDEL",P4HB,PDI; Prolyl 4-hydroxylase subunit beta; Cellular thyroid hormone-binding protein; p55,508,57117,4.49,">>> Function: transporter activity Function: electron transporter activity Function: catalytic activity Function: isomerase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: endoplasmic reticulum","Posttranslational modification, protein turnover, chaperones",PF00085:Thioredoxin,HGNC:8548,Endoplasmic reticulum lumen. Melanosome. Cell membrane,,"","",1-17,None,Non Essential,1MEK,P4HB,P4HB,X07077,Chromosome:17,17q25 545,Probable arylformamidase,2009-05-19 16:40:35 UTC,2009-06-30 03:51:43 UTC,Q63HM1,"Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the conversion of tryptophan to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites (By similarity)","",">Probable arylformamidase MMDVSGVGFPSKVPWKKMSAEELENQYCPSRWVVRLGAEEALRTYSQIGIEATTRARATRKSLLHVPYGD GEGEKVDIYFPDESSEALPFFLFFHGGYWQSGSKDESAFMVHPLTAQGVAVVIVAYGIAPKGTLDHMVDQ VTRSVAFVQKRYPSNKGIYLCGHSAGAHLAAMMLLADWTKHGVTPNLRGFFLVSGVFDLEPIVYTSQNVA LQLTLEDAQRNNPQLKVAQAQPVDPTCRVLVVVGQFDSPEFHRQSWEFYQVLPVQTLCQGEWKASFEELH DVDHFEIVENLTQKDNVLTQIILKTIFQ",AFMID,Kynurenine formamidase; KF,308,34556,5.78,"",Lipid transport and metabolism,"",HGNC:20910,"Cytoplasm, cytosol (By similarity). Nucleus (By similarity)",,"","",None,None,Non Essential,"",AFMID,AFMID,BX648442,Chromosome:17,17q25.3 546,Cytochrome P450 4B1,2009-05-19 18:12:12 UTC,2009-06-30 03:51:41 UTC,P13584,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics","",">Cytochrome P450 4B1 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKV VSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKL LTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSS YYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR RHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG DQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWP DPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQL VLRSKNGFHLHLKPLGPGSGK",CYP4B1,CYPIVB1; P450-HP,511,58992,8.39,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2644,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP4B1,CYP4B1,AY064486,"","" 547,Neuronal acetylcholine receptor subunit alpha-2,2009-05-20 17:57:40 UTC,2009-06-30 03:51:34 UTC,Q15822,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Neuronal acetylcholine receptor subunit alpha-2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGY NRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPADFGNITSLRVPSEMI WIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAK IDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLIS CLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL NVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVK EDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI",CHRNA2,"",529,59736,6.02,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1956,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-26,"265-289 297-315 331-352 503-521",Non Essential,"",CHRNA2,CHRNA2,BC153866,"","" 548,Neuronal acetylcholine receptor subunit alpha-4,2009-05-20 17:59:14 UTC,2009-06-30 03:51:37 UTC,P43681,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Neuronal acetylcholine receptor subunit alpha-4 MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTK AHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWV IVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCIS VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLD IVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGP SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQ YCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPL SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI",CHRNA4,"",627,69958,7.21,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1958,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-28,"243-267 275-293 309-330 601-619",Non Essential,"",CHRNA4,CHRNA4,X87629,Chromosome:20,20q13.2-q13.3 549,Neuronal acetylcholine receptor subunit alpha-5,2009-05-20 18:00:18 UTC,2009-06-30 03:51:45 UTC,P30532,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Neuronal acetylcholine receptor subunit alpha-5 MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLND KIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNAD GRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKR DFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGE KICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAP LVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDW KFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK",CHRNA5,"",468,53055,6.98,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1959,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-22,"255-275 282-302 317-337 430-451",Non Essential,"",CHRNA5,CHRNA5,BC033639,Chromosome:15,15q24 550,Neuronal acetylcholine receptor subunit alpha-7,2009-05-20 18:01:09 UTC,2009-06-30 03:51:44 UTC,P36544,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin","",">Neuronal acetylcholine receptor subunit alpha-7 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQ VLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQY LPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFY ECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVA EIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE DKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA PNFVEAVSKDFA",CHRNA7,"",502,56450,6.44,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1960,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-22,"231-255 262-280 296-317 470-490",Non Essential,"",CHRNA7,CHRNA7,AF332758,Chromosome:15,15q14 551,Neuronal acetylcholine receptor subunit alpha-9,2009-05-20 18:01:35 UTC,2009-06-30 03:51:34 UTC,Q9UGM1,"Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion","",">Neuronal acetylcholine receptor subunit alpha-9 MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDM DERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYD GLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPA VKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMT VFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLF VYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQ YKVLTRNIEYIAKCLKDHKATSSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD",CHRNA9,Nicotinic acetylcholine receptor subunit alpha 9; NACHR alpha 9,479,54781,6.42,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:14079,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-25,"238-262 269-287 302-323 458-476",Non Essential,"",CHRNA9,CHRNA9,AF227732,"","" 552,Neuronal acetylcholine receptor subunit beta-2,2009-05-20 18:01:50 UTC,2009-06-30 03:51:36 UTC,P17787,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Neuronal acetylcholine receptor subunit beta-2 MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISV HEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYD GSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPG RRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFL LLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQ QPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC GCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTT FLHSDHSAPSSK",CHRNB2,"",502,57020,6.77,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1962,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-25,"234-258 266-284 300-321 459-478",Non Essential,"",CHRNB2,CHRNB2,BC075041,"","" 553,Neuronal acetylcholine receptor subunit beta-4,2009-05-20 18:02:06 UTC,2009-06-30 03:51:42 UTC,P30926,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Neuronal acetylcholine receptor subunit beta-4 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNE REQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGS VLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRR TVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLL ISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRP GPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASE GPYAAQRD",CHRNB4,"",498,56380,8.45,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1964,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-21,"237-257 266-286 299-319 461-481",Non Essential,"",CHRNB4,CHRNB4,X68275,Chromosome:15,15q24 554,"6-phosphofructokinase, muscle type",2009-05-21 15:31:56 UTC,2009-06-30 03:51:38 UTC,P08237,"ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate","",">6-phosphofructokinase, muscle type MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATW ESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQ KAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGR HCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIK NLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLME CVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVR STVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNI QGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSA AGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEK CNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRI FANTPDSGCVLGMRKRALVFQPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHI TRKRSGEAAV",PFKM,Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme A; PFK-A; Phosphofructokinase-M,780,85184,8.07,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: phosphotransferase activity, alcohol group as acceptor Function: phosphofructokinase activity Function: 6-phosphofructokinase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: alcohol metabolism Process: monosaccharide metabolism Process: hexose metabolism Process: glucose metabolism Process: glucose catabolism Process: glycolysis || >>> Component: protein complex Component: 6-phosphofructokinase complex Component: cell Component: intracellular Component: cytoplasm",Carbohydrate transport and metabolism,PF00365:PFK,HGNC:8877,"",,"","",None,None,Non Essential,"",PFKM,PFKM,M24925,Chromosome:12,12q13.3 555,"6-phosphofructokinase, liver type",2009-05-21 15:32:13 UTC,2009-06-30 03:51:39 UTC,P17858,"ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate","",">6-phosphofructokinase, liver type MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANW LSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELV AEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGR HCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVK DLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLME CVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRS AVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIH ALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSAS GTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKC HDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVF ANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVT RRTLSMDKGF",PFKL,Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme B; PFK-B,780,85020,7.54,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: phosphotransferase activity, alcohol group as acceptor Function: phosphofructokinase activity Function: 6-phosphofructokinase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: alcohol metabolism Process: monosaccharide metabolism Process: hexose metabolism Process: glucose metabolism Process: glucose catabolism Process: glycolysis || >>> Component: protein complex Component: 6-phosphofructokinase complex Component: cell Component: intracellular Component: cytoplasm",Carbohydrate transport and metabolism,PF00365:PFK,HGNC:8876,"",,"","",None,None,Non Essential,"",PFKL,PFKL,BC009919,Chromosome:21,21q22.3 556,6-phosphofructokinase type C,2009-05-21 15:32:29 UTC,2009-06-30 03:51:47 UTC,Q01813,"ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate","",">6-phosphofructokinase type C MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDG GSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKE WSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQR TFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQN KPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGN HAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGA PAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEE IATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTIT DTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTI QRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAK LKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDV SDSGQLEHVQPWSV",PFKP,"Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme C; PFK-C; 6-phosphofructokinase, platelet type",784,85597,7.60,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: phosphotransferase activity, alcohol group as acceptor Function: phosphofructokinase activity Function: 6-phosphofructokinase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: alcohol metabolism Process: monosaccharide metabolism Process: hexose metabolism Process: glucose metabolism Process: glucose catabolism Process: glycolysis || >>> Component: protein complex Component: 6-phosphofructokinase complex Component: cell Component: intracellular Component: cytoplasm",Carbohydrate transport and metabolism,PF00365:PFK,HGNC:8878,"",,"","",None,None,Non Essential,"",PFKP,PFKP,M64784,Chromosome:10,10p15.3-p15.2 557,Glyceraldehyde-3-phosphate dehydrogenase,2009-05-21 15:37:18 UTC,2009-06-30 03:51:41 UTC,P04406,Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway,"",">Glyceraldehyde-3-phosphate dehydrogenase MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVIN GNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKY DNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPAS TGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQ VVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE",GAPDH,GAPDH,335,36054,8.73,">>> Function: binding Function: cofactor binding Function: coenzyme binding Function: NAD binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Function: glyceraldehyde-3-phosphate dehydrogenase activity Function: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: alcohol metabolism Process: monosaccharide metabolism Process: hexose metabolism Process: glucose metabolism Process: glucose catabolism Process: glycolysis || >>> Component: Not Available",Carbohydrate transport and metabolism,"PF02800:Gp_dh_C PF00044:Gp_dh_N",HGNC:4141,"Cytoplasm. Cytoplasm, perinuclear region. Membrane",,"","",None,None,Non Essential,1J0X,GAPDH,GAPDH,BC083511,Chromosome:12,12p13 558,"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific",2009-05-21 15:37:42 UTC,2009-06-30 03:51:50 UTC,O14556,May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity),"",">Glyceraldehyde-3-phosphate dehydrogenase, testis-specific MSKRDIVLTNVTVVQLLRQPCPVTRAPPPPEPKAEVEPQPQPEPTPVREEIKPPPPPLPPHPATPPPKMV SVARELTVGINGFGRIGRLVLRACMEKGVKVVAVNDPFIDPEYMVYMFKYDSTHGRYKGSVEFRNGQLVV DNHEISVYQCKEPKQIPWRAVGSPYVVESTGVYLSIQAASDHISAGAQRVVISAPSPDAPMFVMGVNEND YNPGSMNIVSNASCTTNCLAPLAKVIHERFGIVEGLMTTVHSYTATQKTVDGPSRKAWRDGRGAHQNIIP ASTGAAKAVTKVIPELKGKLTGMAFRVPTPDVSVVDLTCRLAQPAPYSAIKEAVKAAAKGPMAGILAYTE DEVVSTDFLGDTHSSIFDAKAGIALNDNFVKLISWYDNEYGYSHRVVDLLRYMFSRDK",GAPDHS,Spermatogenic glyceraldehyde-3-phosphate dehydrogenase; Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; GAPDH-2,408,44502,8.34,">>> Function: binding Function: cofactor binding Function: coenzyme binding Function: NAD binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Function: glyceraldehyde-3-phosphate dehydrogenase activity Function: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: alcohol metabolism Process: monosaccharide metabolism Process: hexose metabolism Process: glucose metabolism Process: glucose catabolism Process: glycolysis || >>> Component: Not Available",Carbohydrate transport and metabolism,"PF02800:Gp_dh_C PF00044:Gp_dh_N",HGNC:24864,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",GAPDHS,GAPDHS,BC036373,Chromosome:19,19q13.12 559,Creatine kinase B-type,2009-05-21 15:40:24 UTC,2009-06-30 03:51:42 UTC,P12277,"Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa","",">Creatine kinase B-type MPFSNSHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRAKSTPSGFTLDDVIQTGVDNPGHPYIM TVGCVAGDEESYEVFKDLFDPIIEDRHGGYKPSDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGF CLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARD WPDARGIWHNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKDYEFMWNPHLGYI LTCPSNLGTGLRAGVHIKLPNLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELV QMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK",CKB,Creatine kinase B chain; B-CK,381,42645,5.30,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity || >>> Process: Not Available || >>> Component: Not Available","","PF00217:ATP-gua_Ptrans PF02807:ATP-gua_PtransN",HGNC:1991,Cytoplasm,,"","",None,None,Non Essential,1G0W,CKB,CKB,M22356,Chromosome:14,14q32 560,Creatine kinase M-type,2009-05-21 15:40:39 UTC,2009-06-30 03:51:36 UTC,P06732,"Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa","",">Creatine kinase M-type MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTGVDNPGHPFIM TVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGY TLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLASGMARD WPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYV LTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQV QLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK",CKM,Creatine kinase M chain; M-CK,381,43102,7.28,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity || >>> Process: Not Available || >>> Component: Not Available","","PF00217:ATP-gua_Ptrans PF02807:ATP-gua_PtransN",HGNC:1994,Cytoplasm,,"","",None,None,Non Essential,1I0E,CKM,CKM,M16440,Chromosome:19,19q13.2-q13.3 561,"Creatine kinase, sarcomeric mitochondrial",2009-05-21 15:40:54 UTC,2009-06-30 03:51:34 UTC,P17540,"Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa","",">Creatine kinase, sarcomeric mitochondrial MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCAEVREQPRLFPPSADYPDLRKHNNCMAECLTP AIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMK HTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLAGRYYKL SEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNM KRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLR LQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK",CKMT2,S-MtCK; Basic-type mitochondrial creatine kinase; Mib-CK,419,47505,8.31,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity || >>> Process: Not Available || >>> Component: Not Available","","PF00217:ATP-gua_Ptrans PF02807:ATP-gua_PtransN",HGNC:1996,Mitochondrion inner membrane,,"","",None,None,Non Essential,1CRK,CKMT2,CKMT2,BC029140,"","" 562,"Creatine kinase, ubiquitous mitochondrial",2009-05-21 15:41:12 UTC,2009-06-30 03:51:44 UTC,P12532,"Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa","",">Creatine kinase, ubiquitous mitochondrial MAGPFSRLLSARPGLRLLALAGAGSLAAGFLLRPEPVRAASERRRLYPPSAEYPDLRKHNNCMASHLTPA VYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFADLFDPVIQERHNGYDPRTMKH TTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLS EMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMK RVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRL QKRGTGGVDTAATGGVFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLERGQDIRIPTPVIHTKH",CKMT1A,U-MtCK; Acidic-type mitochondrial creatine kinase; Mia-CK,417,47037,8.47,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity || >>> Process: Not Available || >>> Component: Not Available","","PF00217:ATP-gua_Ptrans PF02807:ATP-gua_PtransN",HGNC:31736,Mitochondrion inner membrane,,"","",None,None,Non Essential,1QK1,CKMT1A,CKMT1A,BC121002,Chromosome:15,15q15 563,Adenylate kinase isoenzyme 1,2009-05-21 15:43:22 UTC,2009-06-30 03:51:40 UTC,P00568,This small ubiquitous enzyme is essential for maintenance and cell growth,"",">Adenylate kinase isoenzyme 1 MEEKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLE TVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVD DNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDALK",AK1,AK 1; ATP-AMP transphosphorylase 1; Myokinase,194,21635,8.99,">>> Function: phosphotransferase activity, phosphate group as acceptor Function: adenylate kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: nucleobase, nucleoside, nucleotide kinase activity Function: nucleotide kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: nucleotide metabolism Process: purine nucleotide metabolism Process: purine nucleoside triphosphate metabolism Process: purine ribonucleoside triphosphate metabolism Process: ATP metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism || >>> Component: cell Component: intracellular Component: cytoplasm",Nucleotide transport and metabolism,PF00406:ADK,HGNC:361,Cytoplasm,,"","",None,None,Non Essential,1Z83,AK1,AK1,BC001116,"","" 564,GTP:AMP phosphotransferase mitochondrial,2009-05-21 15:43:44 UTC,2009-06-30 03:51:49 UTC,Q9UIJ7,NTP + AMP = NDP + ADP,"",">GTP:AMP phosphotransferase mitochondrial MGASARLLRAVIMGAPGSGKGTVSSRITTHFELKHLSSGDLLRDNMLRGTEIGVLAKAFIDQGKLIPDDV MTRLALHELKNLTQYSWLLDGFPRTLPQAEALDRAYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNI EFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGTETNKIWPYVYA FLQTKVPQRSQKASVTP",AK3,Adenylate kinase 3; AK 3; Adenylate kinase 3 alpha-like 1,227,25566,9.64,">>> Function: adenylate kinase activity Function: kinase activity Function: nucleobase, nucleoside, nucleotide kinase activity Function: nucleotide kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: phosphotransferase activity, phosphate group as acceptor Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism || >>> Component: Not Available",Nucleotide transport and metabolism,"PF00406:ADK PF05191:ADK_lid",HGNC:17376,Mitochondrion matrix (By similarity),,"","",None,None,Non Essential,2AK3,AK3,AK3,BC013771,"","" 565,"Adenylate kinase isoenzyme 4, mitochondrial",2009-05-21 15:44:00 UTC,2009-06-30 03:51:48 UTC,P27144,ATP + AMP = 2 ADP,"",">Adenylate kinase isoenzyme 4, mitochondrial MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVIT RLMMSELENRRGQHWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDF NPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTETNKIWPYVYTLF SNKITPIQSKEAY",AK3L1,Adenylate kinase 3-like; ATP-AMP transphosphorylase,223,25268,8.66,">>> Function: adenylate kinase activity Function: kinase activity Function: nucleobase, nucleoside, nucleotide kinase activity Function: nucleotide kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: phosphotransferase activity, phosphate group as acceptor Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism || >>> Component: Not Available",Nucleotide transport and metabolism,"PF00406:ADK PF05191:ADK_lid",HGNC:363,Mitochondrion matrix,,"","",None,None,Non Essential,"",AK3L1,AK3L1,BC146653,"","" 566,"Adenylate kinase isoenzyme 2, mitochondrial",2009-05-21 15:44:40 UTC,2009-06-30 03:51:41 UTC,P54819,This small ubiquitous enzyme is essential for maintenance and cell growth,"",">Adenylate kinase isoenzyme 2, mitochondrial MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDA GKLVSDEMVVELIEKNLETPLCKNGFLLDGFPRTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLLIRRIT GRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQTTPLIEYYRKRGIHSAI DASQTPDVVFASILAAFSKATCKDLVMFI",AK2,AK 2; ATP-AMP transphosphorylase 2,239,26478,7.97,">>> Function: adenylate kinase activity Function: kinase activity Function: nucleobase, nucleoside, nucleotide kinase activity Function: nucleotide kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: phosphotransferase activity, phosphate group as acceptor Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism || >>> Component: Not Available",Nucleotide transport and metabolism,"PF00406:ADK PF05191:ADK_lid",HGNC:362,Mitochondrion intermembrane space,,"","",None,None,Non Essential,2AK2,AK2,AK2,BC070127,"","" 567,Adenylate kinase isoenzyme 5,2009-05-21 15:45:01 UTC,2009-06-30 03:51:34 UTC,Q9Y6K8,"Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP","",">Adenylate kinase isoenzyme 5 MGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLV PSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSL PVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSIIF",AK5,AK 5; ATP-AMP transphosphorylase 5,198,22088,5.16,">>> Function: phosphotransferase activity, phosphate group as acceptor Function: adenylate kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: nucleobase, nucleoside, nucleotide kinase activity Function: nucleotide kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: nucleotide metabolism Process: purine nucleotide metabolism Process: purine nucleoside triphosphate metabolism Process: purine ribonucleoside triphosphate metabolism Process: ATP metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism || >>> Component: cell Component: intracellular Component: cytoplasm",Nucleotide transport and metabolism,PF00406:ADK,HGNC:365,Cytoplasm,,"","",None,None,Non Essential,"",AK5,AK5,AF062595,"","" 568,Adenylate kinase isoenzyme 6,2009-05-21 15:45:16 UTC,2009-06-30 03:51:47 UTC,Q9Y3D8,"Broad activity as an NMP kinase. AMP and dAMP are the preferred substrates of all tested NMPs, but CMP and dCMP are also good substrates. IMP can be phosphorylated, but to a much lesser extent. Adenylate and cytidylate can serve as phosphate acceptors","",">Adenylate kinase isoenzyme 6 MLLPNILLTGTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDRVVDELDNQMR EGGVIVDYHGCDFFPERWFHIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEI VHQLPSNKPEELENNVDQILKWIEQWIKDHNS",AK6,ATP-AMP transphosphorylase 6,172,20062,4.21,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: shikimate kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: amino acid biosynthesis || >>> Component: Not Available",Nucleotide transport and metabolism,PF00004:AAA,"",Nucleus,,"","",None,None,Non Essential,1RKB,AK6,"",BC007426,"","" 569,Putative adenylate kinase 7,2009-05-21 15:45:41 UTC,2009-06-30 03:51:42 UTC,Q96M32,ATP + AMP = 2 ADP,"",">Putative adenylate kinase 7 MAEEEETAALTEKVIRTQRVFINLLDSYSSGNIGKFLSNCVVGASLEEITEEEEEEDENKSAMLEASSTK VKEGTFQIVGTLSKPDSPRPDFAVETYSAISREDLLMRLLECDVIIYNITESSQQMEEAIWAVSALSEEV SHFEKRKLFILLSTVMTWARSKALDPEDSEVPFTEEDYRRRKSHPNFLDHINAEKMVLKFGKKARKFAAY VVAAGLQYGAEGGMLHTFFKMAWLGEIPALPVFGDGTNVIPTIHVLDLAGVIQNVIDHVPKPHYLVAVDE SVHTLEDIVKCISKNTGPGKIQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQTGFVE NINTILKEYKQSRGLMPIKICILGPPAVGKSSIAKELAKYYKLHHIQLKDVISEAIAKLEAIVAPNDVGE GEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQA KDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALSNY RDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERL AREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECC NVRPEDPVDFLAEYLFKNNPEAQ",AK7,"",723,82673,4.40,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: nucleobase, nucleoside, nucleotide kinase activity Function: nucleotide kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism || >>> Component: Not Available","",PF05186:Dpy-30,HGNC:20091,"",,"","",None,None,Non Essential,"",AK7,AK7,AK057426,Chromosome:14,14q32.2 570,Myoglobin,2009-05-22 22:00:11 UTC,2009-06-30 03:51:36 UTC,P02144,Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles,"",">Myoglobin MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLFKGHPETLEKFDKFKHLKSEDEMKASEDLKKHGATVL TALGGILKKKGHHEAEIKPLAQSHATKHKIPVKYLEFISECIIQVLQSKHPGDFGADAQGAMNKALELFR KDMASNYKELGFQG",MB,"",154,17184,7.86,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: Not Available","",PF00042:Globin,HGNC:6915,"",,"","",None,None,Non Essential,2MM1,MB,MB,BC014547,Chromosome:22,22q13.1 571,Basic salivary proline-rich protein 1,2009-05-25 21:39:23 UTC,2009-06-30 03:51:49 UTC,P04280,"","",">Basic salivary proline-rich protein 1 MLLILLSVALLALSSAQNLNEDVSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQG PPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG PPPQGDKSQSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSQ SPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPQQGGNRPQGPPPPGKPQGPPPQGDKSRSPQSPPGKP QGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARAPPGKPQGPPQQEG NNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ",PRB1,Salivary proline-rich protein; Contains: RecName: Basic peptide IB-6; Contains: RecName: Peptide P-H,392,38546,11.88,"","Cell cycle control, cell division, chromosome partitioning","",HGNC:9337,"",,"","",1-16,None,Non Essential,"",PRB1,PRB1,S62941,Chromosome:12,12p13.2 572,Lactoperoxidase,2009-05-25 22:44:50 UTC,2009-06-30 03:51:38 UTC,P22079,Donor + H(2)O(2) = oxidized donor + 2 H(2)O,"",">Lactoperoxidase MRVLLHLPALLASLILLQAAASTTRAQTTRTSAISDTVSQAKVQVNKAFLDSRTRLKTAMSSETPTSRQL SEYLKHAKGRTRTAIRNGQVWEESLKRLRQKASLTNVTDPSLDLTSLSLEVGCGAPAPVVRCDPCSPYRT ITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLD QNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRA GFVCPTPPYKSLAREQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKK PSPCEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAF VQIITFRDYLPILLGDHMQKWIPPYQGYSESVDPRISNVFTFAFRFGHLEVPSSMFRLDENYQPWGPEPE LPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIHGFDLAAINTQRCRD HGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLAC LLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQKMSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAID KLDLSPWASVKN",LPO,LPO; Salivary peroxidase; SPO,712,80289,8.76,">>> Function: antioxidant activity Function: peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","",PF03098:An_peroxidase,HGNC:6678,"Secreted, extracellular space",,"","",1-26,None,Non Essential,"",LPO,LPO,M58151,Chromosome:17,17q23.1 573,Myeloperoxidase,2009-05-25 22:54:30 UTC,2009-06-30 03:51:41 UTC,P05164,"Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity","",">Myeloperoxidase MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAK QLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNV TDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLP YGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVN CETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLA RNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRI ANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQ NQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKL MEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLP RIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS",MPO,MPO; Contains: RecName: 89 kDa myeloperoxidase; Contains: RecName: 84 kDa myeloperoxidase; Contains: RecName: Myeloperoxidase light chain; Contains: RecName: Myeloperoxidase heavy chain,745,83870,9.14,">>> Function: antioxidant activity Function: peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","",PF03098:An_peroxidase,HGNC:7218,Lysosome,,"","",1-48,None,Non Essential,1MYP,MPO,MPO,D14466,Chromosome:17,17q23.1 574,Sodium/iodide cotransporter,2009-05-26 06:06:21 UTC,2009-06-30 03:51:45 UTC,Q92911,Mediates iodide uptake in the thyroid gland,"",">Sodium/iodide cotransporter MEAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSASFMSA VQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVA TMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGV MLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKL ALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSG TLSTASTSINAMAAVTVEDLIKPRLRSLAPRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVM GVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNA SGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAP GLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNEDRLFFLGQKELEGAGSWTPCV GHDGGRDQQETNL",SLC5A5,Na(+)/I(-) cotransporter; Sodium-iodide symporter; Na(+)/I(-)-symporter; Solute carrier family 5 member 5,643,68667,7.43,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane",Amino acid transport and metabolism,PF00474:SSF,HGNC:11040,Membrane,,"","",None,"17-37 54-74 89-109 137-157 164-184 187-207 242-262 287-307 327-347 392-412 417-437 445-465 526-546",Non Essential,"",SLC5A5,SLC5A5,AF260700,Chromosome:19,19p13.2-p12 575,Carbonic anhydrase 3,2009-05-26 17:55:06 UTC,2009-06-30 03:51:37 UTC,P07451,Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 3 MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVF DDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGI AVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLL LKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASFK",CA3,Carbonic anhydrase III; CA-III; Carbonate dehydratase III,260,29558,7.38,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1374,Cytoplasm,,"","",None,None,Non Essential,"",CA3,CA3,AJ006473,"","" 576,ATP-sensitive inward rectifier potassium channel 1,2009-05-26 18:02:06 UTC,2009-06-30 03:51:41 UTC,P48048,"In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium","",">ATP-sensitive inward rectifier potassium channel 1 MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWT TVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQV TIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLL IRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFH MAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEV ETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM",KCNJ1,"Potassium channel, inwardly rectifying subfamily J member 1; ATP-regulated potassium channel ROM-K; Kir1.1",391,44795,9.04,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6255,Membrane,,"","",None,"78-102 156-177",Non Essential,"",KCNJ1,KCNJ1,S78737,Chromosome:11,11q24 577,Inward rectifier potassium channel 2,2009-05-26 18:02:37 UTC,2009-06-30 03:51:39 UTC,P63252,"Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium","",">Inward rectifier potassium channel 2 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLA DIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQ TTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCL MWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLY DLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEV PNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRP LRRESEI",KCNJ2,"Potassium channel, inwardly rectifying subfamily J member 2; Inward rectifier K(+) channel Kir2.1; Cardiac inward rectifier potassium channel; IRK1",427,48289,5.47,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","","PF01007:IRK PF08466:IRK_N",HGNC:6263,Membrane,,"","",None,"82-106 157-178",Non Essential,1U4F,KCNJ2,KCNJ2,AF021139,Chromosome:17,17q23.1-q24.2 578,Inward rectifier potassium channel 4,2009-05-26 18:03:44 UTC,2009-06-30 03:51:46 UTC,P48050,"This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity)","",">Inward rectifier potassium channel 4 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSW LFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFR CVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLR KSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELE SEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSA RELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFG SHLDLERMQASLPLDNISYRRESAI",KCNJ4,"Potassium channel, inwardly rectifying subfamily J member 4; Inward rectifier K(+) channel Kir2.3; Hippocampal inward rectifier; HIRK2; HRK1; HIR",445,49501,6.15,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6265,Membrane,,"","",None,"56-80 149-170",Non Essential,"",KCNJ4,KCNJ4,BC113508,Chromosome:22,22q13.1 579,ATP-sensitive inward rectifier potassium channel 11,2009-05-26 18:04:08 UTC,2009-06-30 03:51:42 UTC,Q14654,"This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity)","",">ATP-sensitive inward rectifier potassium channel 11 MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPH TLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTE ECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMI ISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQD LEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLD EDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS",KCNJ11,"Potassium channel, inwardly rectifying subfamily J member 11; Inward rectifier K(+) channel Kir6.2; IKATP",390,43541,8.10,">>> Function: ATP-activated inward rectifier potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6257,Membrane,,"","",None,"69-93 145-166",Non Essential,"",KCNJ11,KCNJ11,BC112358,Chromosome:11,11p15.1 580,ATP-sensitive inward rectifier potassium channel 12,2009-05-26 18:04:26 UTC,2009-06-30 03:51:48 UTC,Q14500,"Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium","",">ATP-sensitive inward rectifier potassium channel 12 MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYLAD MFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVMQVHGFMAAFLFSIET QTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLC LMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPL FGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYE VPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGG VLEQRPYRRESEI",KCNJ12,"Potassium channel, inwardly rectifying subfamily J member 12; Inward rectifier K(+) channel Kir2.2; Kir2.2v; IRK2",433,49002,5.79,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","","PF01007:IRK PF08466:IRK_N",HGNC:6258,Membrane,,"","",None,"81-105 158-179",Non Essential,"",KCNJ12,KCNJ12,AF005214,Chromosome:17,17p11.2 581,Inward rectifier potassium channel 13,2009-05-26 18:04:55 UTC,2009-06-30 03:51:39 UTC,O60928,"Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium","",">Inward rectifier potassium channel 13 MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVFSASFVVHWLV FAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAI QMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAHMDGKPNLIFQVANTRPSPLTSVRVSAVLYQ ERENGKLYQTSVDFHLDGISSDECPFFIFPLTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGE ICQRRTSYLPSEIMLHHCFASLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDN FQISETGLTE",KCNJ13,"Potassium channel, inwardly rectifying subfamily J member 13; Inward rectifier K(+) channel Kir7.1",360,40530,6.23,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6259,Membrane,,"","",None,"54-78 134-155",Non Essential,"",KCNJ13,KCNJ13,AF082182,"","" 582,ATP-sensitive inward rectifier potassium channel 15,2009-05-26 18:05:16 UTC,2009-06-30 03:51:48 UTC,Q99712,"Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium","",">ATP-sensitive inward rectifier potassium channel 15 MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLF AATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECP HAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQC QLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELV VLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQ LEEKYRQEDQRERELRTLLLQQSNV",KCNJ15,"Potassium channel, inwardly rectifying subfamily J member 15; Inward rectifier K(+) channel Kir4.2; Kir1.3",375,42578,7.78,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6261,Membrane,,"","",None,"64-88 142-163",Non Essential,"",KCNJ15,KCNJ15,BC013327,Chromosome:21,21q22.2 583,G protein-activated inward rectifier potassium channel 4,2009-05-26 18:06:02 UTC,2009-06-30 03:51:39 UTC,P48544,"This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium","",">G protein-activated inward rectifier potassium channel 4 MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQET YRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGFVSAF LFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISM RDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEI NEKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNT FHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV",KCNJ5,"GIRK4; Potassium channel, inwardly rectifying subfamily J member 5; Inward rectifier K(+) channel Kir3.4; Heart KATP channel; KATP-1; Cardiac inward rectifier; CIR",419,47669,4.96,">>> Function: G-protein activated inward rectifier potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6266,Membrane,,"","",None,"87-111 164-185",Non Essential,"",KCNJ5,KCNJ5,BC074839,Chromosome:11,11q24 584,ATP-sensitive inward rectifier potassium channel 10,2009-05-26 18:06:31 UTC,2009-06-30 03:51:41 UTC,P78508,"May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity)","",">ATP-sensitive inward rectifier potassium channel 10 MTSVAKVYYSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLL FSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEEC PLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIG CQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELV LILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYG DPEKLKLEESLREQAEKEGSALSVRISNV",KCNJ10,"Potassium channel, inwardly rectifying subfamily J member 10; Inward rectifier K(+) channel Kir1.2; ATP-dependent inwardly rectifying potassium channel Kir4.1",379,42509,8.20,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6256,Membrane,,"","",None,"65-89 143-164",Non Essential,"",KCNJ10,KCNJ10,AL513302,"","" 585,ATP-sensitive inward rectifier potassium channel 14,2009-05-26 18:06:55 UTC,2009-06-30 03:51:41 UTC,Q9UNX9,"Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity)","",">ATP-sensitive inward rectifier potassium channel 14 MGLARALRRLSGALDSGDSRAGDEEEAGPGLCRNGWAPAPVQSPVGRRRGRFVKKDGHCNVRFVNLGGQG ARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLAFWLIASLHGDLAAPPPPAPCFSHVASFLAAFLF ALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRD HRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDS ASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQYEVDYRHFH RTYEVPGTPVCSAKELDERAEQASHSLKSSFPGSLTAFCYENELALSCCQEEDEDDETEEGNGVETEDGA ASPRVLTPTLALTLPP",KCNJ14,"Potassium channel, inwardly rectifying subfamily J member 14; Inward rectifier K(+) channel Kir2.4; IRK4",436,47846,5.10,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6260,Membrane,,"","",None,"87-111 162-183",Non Essential,"",KCNJ14,KCNJ14,BC035918,Chromosome:19,19q13 586,Inward rectifier potassium channel 16,2009-05-26 18:07:18 UTC,2009-06-30 03:51:37 UTC,Q9NPI9,"Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance","",">Inward rectifier potassium channel 16 MSYYGSSYHIINADAKYPGYPPEHIIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKW RHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLLNDPDITPCVDNVHSFTGAFLFSLETQTTIGYGYRCVT EECSVAVLMVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNH VVEGTVRAQLLRYTEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILV TFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQ LHIEKAPPVRESCTSDTKARRRSFSAVAIVSSCENPEETTTSATHEYRETPYQKALLTLNRISVESQM",KCNJ16,"Potassium channel, inwardly rectifying subfamily J member 16; Inward rectifier K(+) channel Kir5.1",418,47950,7.94,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6262,Membrane,,"","",None,"71-95 146-167",Non Essential,"",KCNJ16,KCNJ16,AF153817,Chromosome:17,17q23.1-q24.2 587,G protein-activated inward rectifier potassium channel 1,2009-05-26 18:07:39 UTC,2009-06-30 03:51:39 UTC,P48549,"This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat","",">G protein-activated inward rectifier potassium channel 1 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSD LFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIET EATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLT LMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPF YDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFE VPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPA KLRKMNSDRFT",KCNJ3,"GIRK1; Potassium channel, inwardly rectifying subfamily J member 3; Inward rectifier K(+) channel Kir3.1",501,56604,8.36,">>> Function: G-protein activated inward rectifier potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6264,Membrane,,"","",None,"81-105 158-179",Non Essential,1U4E,KCNJ3,KCNJ3,BC022495,"","" 588,G protein-activated inward rectifier potassium channel 2,2009-05-26 18:08:05 UTC,2009-06-30 03:51:36 UTC,P48051,"This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium","",">G protein-activated inward rectifier potassium channel 2 MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNV RETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFV SAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAV ISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIIS HEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVD YNSFHETYETSTPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLENE SKV",KCNJ6,"GIRK2; Potassium channel, inwardly rectifying subfamily J member 6; Inward rectifier K(+) channel Kir3.2; KATP-2; BIR1",423,48452,5.04,">>> Function: G-protein activated inward rectifier potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6267,Membrane,,"","",None,"90-114 167-188",Non Essential,"",KCNJ6,KCNJ6,S78685,Chromosome:21,21q22.1|21q22.13-q22.2 589,ATP-sensitive inward rectifier potassium channel 8,2009-05-26 18:08:25 UTC,2009-06-30 03:51:42 UTC,Q15842,"This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity)","",">ATP-sensitive inward rectifier potassium channel 8 MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDIFTTLVDLKWR HTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVCVTNVRSFTSAFLFSIEVQVT IGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMF RVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDI SATDLANQDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAA PRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQN TSES",KCNJ8,"Potassium channel, inwardly rectifying subfamily J member 8; Inwardly rectifier K(+) channel Kir6.1; uKATP-1",424,47969,9.70,">>> Function: ATP-activated inward rectifier potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6269,Membrane,,"","",None,"70-94 155-176",Non Essential,"",KCNJ8,KCNJ8,BC000544,Chromosome:12,12p11.23 590,G protein-activated inward rectifier potassium channel 3,2009-05-26 18:08:47 UTC,2009-06-30 03:51:36 UTC,Q92806,"This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity)","",">G protein-activated inward rectifier potassium channel 3 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLSLLFFVLAYAL TWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLL LQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLI RSRQTLEGEFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMV EATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLY WSIPSRLDEKVEEEGAGEGAGGEAGADKEQNGCLPPPESESKV",KCNJ9,"GIRK3; Potassium channel, inwardly rectifying subfamily J member 9; Inwardly rectifier K(+) channel Kir3.3",393,44020,4.59,">>> Function: G-protein activated inward rectifier potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: inward rectifier potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF01007:IRK,HGNC:6270,Membrane,,"","",None,"58-82 135-156",Non Essential,"",KCNJ9,KCNJ9,AL121987,"","" 591,Potassium voltage-gated channel subfamily KQT member 1,2009-05-26 18:22:14 UTC,2009-06-30 03:51:36 UTC,P51787,"Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea","",">Potassium voltage-gated channel subfamily KQT member 1 MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPGPAPPASPAAP AAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFS VLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASM VVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFV YLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSG FALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLD LEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQ RRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALITDMLHQLLSLHGGSTPGSGGP PREGGAHITQPCGSGGSVDPELFLPSNTLPTYEQLTVPRRGPDEGS",KCNQ1,Voltage-gated potassium channel subunit Kv7.1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1,676,74699,10.39,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF03520:KCNQ_channel",HGNC:6294,Cell membrane,,"","",None,"122-142 148-168 197-217 226-248 262-282 328-348",Non Essential,"",KCNQ1,KCNQ1,AF051426,Chromosome:11,11p15.5 592,Potassium voltage-gated channel subfamily KQT member 2,2009-05-26 18:22:33 UTC,2009-06-30 03:51:46 UTC,O43526,"Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors","",">Potassium voltage-gated channel subfamily KQT member 2 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKR NAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVE YFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGY GDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATN LSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKVPKSWSFGDRS RARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLR PYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQV LSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKN FSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQED TPGCRPPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK",KCNQ2,Voltage-gated potassium channel subunit Kv7.2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; KQT-like 2,872,95848,9.59,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF03520:KCNQ_channel",HGNC:6296,Membrane,,"","",None,"92-112 123-143 167-187 196-218 232-252 292-312",Non Essential,"",KCNQ2,KCNQ2,BC000699,Chromosome:20,20q13.3 593,Potassium voltage-gated channel subfamily KQT member 3,2009-05-26 18:22:50 UTC,2009-06-30 03:51:44 UTC,O43525,"Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs","",">Potassium voltage-gated channel subfamily KQT member 3 MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLE GGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILA VLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASV PVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVY LVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGI LGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAAS SQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDA GTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSR IKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQ DMGKKLDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFH QVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPY SDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDT DTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI",KCNQ3,Voltage-gated potassium channel subunit Kv7.3; Potassium channel subunit alpha KvLQT3; KQT-like 3,872,96743,9.20,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF03520:KCNQ_channel",HGNC:6297,Membrane,,"","",None,"122-142 153-173 197-217 226-247 262-282 331-351",Non Essential,"",KCNQ3,KCNQ3,AF033347,"","" 594,Potassium voltage-gated channel subfamily KQT member 4,2009-05-26 18:23:11 UTC,2009-06-30 03:51:40 UTC,P56696,"Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors","",">Potassium voltage-gated channel subfamily KQT member 4 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACG QRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMI VVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQ ILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTIT LTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAW RLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHR PGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQQLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTR FRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKD VIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIE HKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD",KCNQ4,Voltage-gated potassium channel subunit Kv7.4; Potassium channel subunit alpha KvLQT4; KQT-like 4,695,77093,9.95,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF03520:KCNQ_channel",HGNC:6298,Basal cell membrane,,"","",None,"98-118 132-152 173-193 202-224 238-258 297-317",Non Essential,"",KCNQ4,KCNQ4,AF105216,"","" 595,Potassium voltage-gated channel subfamily KQT member 5,2009-05-26 18:23:37 UTC,2009-06-30 03:51:40 UTC,Q9NR82,"Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors","",">Potassium voltage-gated channel subfamily KQT member 5 MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGG GGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGC LILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVL IASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFS SFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGF ALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEASSSQKLS FKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDA DTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDM LCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQV LRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQ TFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNP AGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTE ELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRS SQSICKAGESTDALSLPHVKLK",KCNQ5,Voltage-gated potassium channel subunit Kv7.5; Potassium channel subunit alpha KvLQT5; KQT-like 5,932,102180,10.01,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF03520:KCNQ_channel",HGNC:6299,Membrane,,"","",None,"126-146 157-177 201-221 230-252 267-287 326-346",Non Essential,"",KCNQ5,KCNQ5,AF263835,"","" 596,Potassium voltage-gated channel subfamily A member 1,2009-05-26 18:38:45 UTC,2009-06-30 03:51:48 UTC,Q09470,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient","",">Potassium voltage-gated channel subfamily A member 1 MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRM RYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEE ERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTV IYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQ KGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAE EAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE GEEQAQLLHVSSPNLASDSDLSRRSSSTMSKYEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSK LLTDV",KCNA1,Voltage-gated potassium channel subunit Kv1.1; HUKI; HBK1,495,56542,4.82,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6218,Membrane,,"","",None,"168-186 221-242 254-274 290-309 326-345 387-408",Non Essential,1EXB,KCNA1,KCNA1,L02750,Chromosome:12,12p13.32 597,Potassium voltage-gated channel subfamily D member 2,2009-05-26 18:39:18 UTC,2009-06-30 03:51:38 UTC,Q9NZV8,Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits,"",">Potassium voltage-gated channel subfamily D member 2 MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSS ERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDR RRENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCG SSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMT DNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSS ASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD KRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCLEKTTN HEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHQGSIQELSTIQ IRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNIVRVSAL",KCND2,Voltage-gated potassium channel subunit Kv4.2,630,70537,8.03,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6238,Cell membrane,,"","",None,"184-204 225-245 260-280 290-310 324-344 385-405",Non Essential,1NN7,KCND2,KCND2,BC110450,"","" 598,Calcium-activated potassium channel subunit alpha 1,2009-05-26 18:40:02 UTC,2009-07-22 22:35:29 UTC,Q12791,"Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)","",">Calcium-activated potassium channel subunit alpha-1 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALI IPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADG TLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFY KDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLI QFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTM STVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLIL ANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIA QSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLM IAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKM SIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQ RNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSG HVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRA DLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPD NSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSAT YFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYG DLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLS HSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL",KCNMA1,"Calcium-activated potassium channel, subfamily M subunit alpha-1; Maxi K channel; MaxiK; BK channel; K(VCA)alpha; BKCA alpha; KCa1.1; Slowpoke homolog; Slo homolog; Slo-alpha; Slo1; hSlo",1236,137561,7.07,">>> Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF03493:BK_channel_a PF00520:Ion_trans",HGNC:6284,Membrane,,"","",None,"87-107 179-199 215-235 240-260 265-285 301-321 368-388",Non Essential,"",KCNMA1,KCNMA1,AF118141,Chromosome:10,10q22.3 599,Potassium voltage-gated channel subfamily A member 10,2009-05-26 18:41:00 UTC,2009-06-30 03:51:42 UTC,Q16322,"Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP","",">Potassium voltage-gated channel subfamily A member 10 MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDY ADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDG ILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPE SSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIV WFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFR IFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMT TVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSR MGSTDSLNKTNGGCSTEKSRK",KCNA10,Voltage-gated potassium channel subunit Kv1.8,511,57786,4.57,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6219,Membrane,,"","",None,"218-238 271-292 303-323 339-358 375-395 436-456",Non Essential,"",KCNA10,KCNA10,BC074990,"","" 600,Potassium voltage-gated channel subfamily A member 3,2009-05-26 18:41:30 UTC,2009-06-30 03:51:39 UTC,P22001,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient","",">Potassium voltage-gated channel subfamily A member 3 MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGG GAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYF DPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERP LPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNS TSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAER QGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE ADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE TEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNN NPNSCVNIKKIFTDV",KCNA3,Voltage-gated potassium channel subunit Kv1.3; HPCN3; HGK5; HuKIII; HLK3,575,63842,5.68,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6221,Membrane,,"","",None,"235-253 295-316 328-348 363-381 398-417 459-481",Non Essential,1QDV,KCNA3,KCNA3,M85217,"","" 601,Potassium voltage-gated channel subfamily A member 4,2009-05-26 18:41:46 UTC,2009-06-30 03:51:46 UTC,P22459,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient","",">Potassium voltage-gated channel subfamily A member 4 MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRRAAARAVAAATAAVEGSGGSGGGSHHHHQSRGA CTSHDPQSSRGSREEEATRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRF YYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQ YFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEE DRALPENEFKKQIWLLFEYPESSDPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGL LNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVI LFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGVLCAIAGVLTIALPVPVIV SNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQ AKGDDSETDKNNCSNAKAVETDV",KCNA4,Voltage-gated potassium channel subunit Kv1.4; HK1; HPCN2; HBK4; HUKII,653,73289,4.67,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF07941:K_channel_TID PF02214:K_tetra",HGNC:6222,Membrane,,"","",None,"308-326 371-392 404-424 443-461 478-497 539-561",Non Essential,1QDV,KCNA4,KCNA4,L02751,Chromosome:11,11p14 602,Potassium voltage-gated channel subfamily A member 5,2009-05-26 18:42:07 UTC,2009-06-30 03:51:38 UTC,P22460,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potasssium ions may pass in accordance with their electrochemical gradient. May play a role in regulating the secretion of insulin in normal pancreatic islets","",">Potassium voltage-gated channel subfamily A member 5 MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPL PDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQ FPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAM ERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERE LLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKA GFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPIT VGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSR GSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL",KCNA5,Voltage-gated potassium channel subunit Kv1.5; HK2; HPCN1,613,67229,5.75,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6224,Membrane,,"","",None,"251-269 325-345 356-377 398-419 434-455 495-516",Non Essential,"",KCNA5,KCNA5,BC099666,Chromosome:12,12p13 603,Potassium voltage-gated channel subfamily C member 4,2009-05-26 18:42:36 UTC,2009-06-30 03:51:49 UTC,Q03721,"This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient","",">Potassium voltage-gated channel subfamily C member 4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDG GGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDV EPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQP RMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPI LTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVR FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPK KRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQ PLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACADGSVRKGTFVLRDLPLQHSPEAACPPTAGT LFLPH",KCNC4,Voltage-gated potassium channel subunit Kv3.4; KSHIIIC,635,69767,6.98,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6236,Membrane,,"","",None,"227-247 278-298 313-333 345-364 381-401 452-472",Non Essential,"",KCNC4,KCNC4,BC101769,"","" 604,Potassium voltage-gated channel subfamily D member 3,2009-05-26 18:42:57 UTC,2009-06-30 03:51:45 UTC,Q9UK17,Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits,"",">Potassium voltage-gated channel subfamily D member 3 MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTE KEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRK RENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTV PGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNE DVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASK FTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRR AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLS YLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNS NLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESR PPPASPGPNTNIPSIASNVVKVSAL",KCND3,Voltage-gated potassium channel subunit Kv4.3,655,73452,8.32,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6239,Membrane,,"","",None,"182-202 222-242 257-277 287-307 321-341 382-402",Non Essential,1S1G,KCND3,KCND3,AL049557,"","" 605,Potassium voltage-gated channel subfamily H member 1,2009-05-26 18:43:16 UTC,2009-06-30 03:51:50 UTC,O95259,Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts,"",">Potassium voltage-gated channel subfamily H member 1 MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFM YGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPI EDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHII LHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEV ISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLF SSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLL YATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICP KDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQ DDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYN LRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGN VLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEV KHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPE SERDIFGAS",KCNH1,Voltage-gated potassium channel subunit Kv10.1; Ether-a-go-go potassium channel 1; hEAG1; h-eag,989,111424,7.63,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08447:PAS_3",HGNC:6250,Membrane,,"","",None,"221-241 249-269 295-315 350-370 377-397 478-498",Non Essential,"",KCNH1,KCNH1,AF078742,"","" 606,Potassium voltage-gated channel subfamily H member 5,2009-05-26 18:43:52 UTC,2009-06-30 03:51:48 UTC,Q8NCM2,Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly,"",">Potassium voltage-gated channel subfamily H member 5 MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYG ELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIED DSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHY CAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISD PKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLV LLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYV SSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRD FLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLR ALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANV RALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSI PVDHPVRKLFQKFKQQKELRNQGSTQGDPERNQLQVESRSLQNGTSITGTSVVTVSQITPIQTSLAYVKT SESLKQNNRDAMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLL SEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTL QEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQVPPQIPCQDIFSVSRPESPE SDKDEIHF",KCNH5,Voltage-gated potassium channel subunit Kv10.2; Ether-a-go-go potassium channel 2; hEAG2,988,111908,7.62,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF00989:PAS",HGNC:6254,Membrane,,"","",None,"218-238 244-264 292-312 320-340 347-367 447-467",Non Essential,"",KCNH5,KCNH5,BC073979,Chromosome:14,14q23.1 607,Potassium channel subfamily T member 2,2009-05-26 18:44:21 UTC,2009-06-30 03:51:42 UTC,Q6UVM3,"Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1","",">Potassium channel subfamily T member 2 MVDLESEVPPLPPRYRFRDLLLGDQGWQNDDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLK LLSCLLYIIRVLLENPSQGNEWSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKGNIWEQILRIPF ILEIINAVPFIISIFWPSLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLI FTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYL WMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQI PMWSQRVIYLQGSALKDQDLLRAKMDDAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQIL KPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVY HIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLIGVRREDNKNILLNPGPRYIMNSTDICFYINITKEEN SAFKNQDQQRKSNVSRSFYHGPSRLPVHSIIASMGTVAIDLQDTSCRSASGPTLSLPTEGSKEIRRPSIA PVLEVADTSSIQTCDLLSDQSEDETTPDEEMSSNLEYAKGYPPYSPYIGSSPTFCHLLHEKVPFCCLRLD KSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPPDMHFLDAICW FPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELT HPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMISIT RLLLGLDTTPGSGFLCSMKITADDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSESQISISVEEW EDTKDSKEQGHHRSNHRNSTSSDQSDHPLLRRKSMQWARRLSRKGPKHSGKTAEKITQQRLNLYRRSERQ ELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRIELNDVVYLIRPDPLAYLPNSEPSRRNS ICNVTGQDSREETQL",KCNT2,Sequence like an intermediate conductance potassium channel subunit; Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1,1135,130503,7.30,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF03493:BK_channel_a PF07885:Ion_trans_2",HGNC:18866,Cell membrane,,"","",None,"64-84 102-122 138-158 165-185 199-219 257-277",Non Essential,"",KCNT2,KCNT2,BC103950,"","" 608,Potassium voltage-gated channel subfamily V member 2,2009-05-26 18:44:44 UTC,2009-06-30 03:51:44 UTC,Q8TDN2,Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values,"",">Potassium voltage-gated channel subfamily V member 2 MLKQSERRRSWSYRPWNTTENEGSQHRRSICSLGARSGSQASIHGWTEGNYNYYIEEDEDGEEEDQWKDD LAEEDQQAGEVTTAKPEGPSDPPALLSTLNVNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCD DYEEQTDEYFFDRDPAVFQLVYNFYLSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRDEL SERLKIQHELRAQAQVEEAEELFRDMRFYGPQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALALN TVEEMQQHSGQGEGGPDLRPILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLVDLVAILPLYLQL LLECFTGEGHQRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAM GIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAFGIILNGMPIS ILYNKFSDYYSKLKAYEYTTIRRERGEVNFMQRARKKIAECLLGSNPQLTPRQEN",KCNV2,Voltage-gated potassium channel subunit Kv8.2,545,62460,6.44,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:19698,Cell membrane,,"","",None,"156-176 262-282 337-357 375-395 411-431 472-492",Non Essential,"",KCNV2,KCNV2,BC101353,"","" 609,Potassium voltage-gated channel subfamily F member 1,2009-05-26 18:45:05 UTC,2009-06-30 03:51:42 UTC,Q9H3M0,Putative voltage-gated potassium channel,"",">Potassium voltage-gated channel subfamily F member 1 MDGSGERSLPEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDY DPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEE IARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVL DAEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMM ELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHP ETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLE TAAKHELELMELNSSSGGEGKTGGSRSDLDNLPPEPAGKEAPSCSSRLKLSHSDTFIPLLTEEKHHRTRL QSCK",KCNF1,Voltage-gated potassium channel subunit Kv5.1; kH1,494,55585,6.24,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6246,Membrane,,"","",None,"184-204 224-244 250-270 290-310 325-345 386-406",Non Essential,"",KCNF1,KCNF1,BC026110,"","" 610,Potassium voltage-gated channel subfamily G member 1,2009-05-26 18:45:27 UTC,2009-06-30 03:51:36 UTC,Q9UIX4,Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity,"",">Potassium voltage-gated channel subfamily G member 1 MTLLPGDNSDYDYSALSCTSDASFHPAFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPEDRRRRIIINVG GIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLR EMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREEEDDALDSEGRDSEGPAEGEGRLGRCM RRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCVGWFS LEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRI LYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVI TMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQFLIKTKS QLSVSQDSDILFGSASSDTRDNN",KCNG1,Voltage-gated potassium channel subunit Kv6.1; kH2,513,57914,6.20,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6248,Membrane,,"","",None,"228-248 268-288 303-323 343-363 377-397 440-460",Non Essential,"",KCNG1,KCNG1,BC006367,Chromosome:20,20q13 611,Potassium voltage-gated channel subfamily G member 3,2009-05-26 18:45:44 UTC,2009-06-30 03:51:47 UTC,Q8TAE7,Potassium channel subunit. Modulates channel activity,"",">Potassium voltage-gated channel subfamily G member 3 MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSADEPGVLGRDEA RPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRNAAADNRSLDDRS RYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQ LQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDL ETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK FRSARYSRSLSTEFLN",KCNG3,Voltage-gated potassium channel subunit Kv6.3; Kv10.1,436,49593,8.31,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:18306,Cell membrane,,"","",None,"168-188 222-242 256-276 287-307 323-343 388-413",Non Essential,"",KCNG3,KCNG3,BC071558,"","" 612,Potassium voltage-gated channel subfamily S member 1,2009-05-26 18:46:04 UTC,2009-06-30 03:51:38 UTC,Q96KK3,Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity),"",">Potassium voltage-gated channel subfamily S member 1 MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALAR FPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADY WGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTM ENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCI AWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIF RVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMT TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSID GVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY",KCNS1,Delayed-rectifier K(+) channel alpha subunit 1; Voltage-gated potassium channel subunit Kv9.1,526,58372,7.16,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6300,Cell membrane,,"","",None,"222-242 275-295 307-327 340-360 376-396 437-457",Non Essential,"",KCNS1,KCNS1,BC075034,Chromosome:20,20q12 613,Potassium channel subfamily U member 1,2009-05-26 18:46:31 UTC,2009-06-30 03:51:45 UTC,A8MYU2,"Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+) (By similarity)","",">Potassium channel subfamily U member 1 MFQTKLRNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKWQIIKGTGIILELFTS GTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIYFINSADPVGSCSSYEDKTIP IDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYYLKSNWLGLRFLRALRLLELPQIL QILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFG DVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLR NFLRDKSGEINTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCS DSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGCLVP GLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFPEVARLCFLKMHLLLIAIEYK SLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRALFYCSVCHDDVFIPELITNCGCKSRSRQHIT VPSVKRMKKCLKGISSRISGQDSPPRVSASTSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKV TLKRTGKSKYKFRNHIVACVFGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNF PQIYILPGCALYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVS EETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTVFSGSFLDSLL ATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNRCKLGLLSLHETILSDVNPRN TFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITRPANEFKLLPSDLVFCAIPFSTACYKRNEEF SLQKSYEIVNKASQTTETHSDTNCPPTIDSVTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQI PLGDNAKENERKTSDEVYDEDPFAYSEPL",KCNU1,"Calcium-activated potassium channel subunit alpha-3; Calcium-activated potassium channel, subfamily M subunit alpha-3; Slowpoke homolog 3; KCa5",1149,129545,7.87,">>> Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane","Replication, recombination and repair","PF03493:BK_channel_a PF00520:Ion_trans",HGNC:18867,Membrane,,"","",None,"25-45 102-122 139-159 164-184 189-209 227-247 292-312",Non Essential,"",KCNU1,KCNU1,"","","" 614,Potassium voltage-gated channel subfamily V member 1,2009-05-26 18:46:54 UTC,2009-06-30 03:51:44 UTC,Q6PIU1,"Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes","",">Potassium voltage-gated channel subfamily V member 1 MPSSGRALLDSPLDSGSLTSLDSSVFCSEGEGEPLALGDCFTVNVGGSRFVLSQQALSCFPHTRLGKLAV VVASYRRPGALAAVPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYW GIDELSIDSCCRDRYFRRKELSETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAAR IFGVISIIFVVVSIINMALMSAELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDRCRFLRKVPNIIDL LAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLL LFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVL ALPIAIINDRFSACYFTLKLKEAAVRQREALKKLTKNIATDSYISVNLRDVYARSIMEMLRLKGRERAST RSSGGDDFWF",KCNV1,Voltage-gated potassium channel subunit Kv8.1; Neuronal potassium channel alpha subunit HNKA,500,56305,5.81,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:18861,Cell membrane,,"","",None,"211-231 239-259 277-297 310-331 346-366 407-427",Non Essential,"",KCNV1,KCNV1,BC028739,"","" 615,Potassium voltage-gated channel subfamily A member 2,2009-05-26 18:47:29 UTC,2009-06-30 03:51:49 UTC,P16389,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient","",">Potassium voltage-gated channel subfamily A member 2 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFD PLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPL PENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTI GYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPED AQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE ADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYV NITKMLTDV",KCNA2,Voltage-gated potassium channel subunit Kv1.2; HBK5; NGK1; HUKIV,499,56717,4.50,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6220,Membrane,,"","",None,"164-182 222-243 255-275 293-311 328-347 389-411",Non Essential,1QDV,KCNA2,KCNA2,L02752,"","" 616,Potassium voltage-gated channel subfamily A member 6,2009-05-26 18:47:45 UTC,2009-06-30 03:51:50 UTC,P17658,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient","",">Potassium voltage-gated channel subfamily A member 6 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDP GRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGC LPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGG VSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLV RFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVF RIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLR ATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV",KCNA6,Voltage-gated potassium channel subunit Kv1.6; HBK2,529,58729,4.63,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6225,Membrane,,"","",None,"175-193 263-284 296-316 340-360 376-396 437-457",Non Essential,"",KCNA6,KCNA6,BC069355,Chromosome:12,12p13 617,Potassium voltage-gated channel subfamily A member 7,2009-05-26 18:48:04 UTC,2009-06-30 03:51:34 UTC,Q96RP8,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity)","",">Potassium voltage-gated channel subfamily A member 7 MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLY YYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQ AARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFF VVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAILRVI RLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFW WAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMFSHVDMQP CGPLEGKANGGLVDGEVPELPPPLWAPPGKHLVTEV",KCNA7,Voltage-gated potassium channel subunit Kv1.7,456,50560,7.37,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6226,Membrane,,"","",None,"144-164 209-229 241-261 276-295 312-332 373-393",Non Essential,"",KCNA7,KCNA7,AY779768,Chromosome:19,19q13.3 618,Potassium voltage-gated channel subfamily B member 1,2009-05-26 18:48:28 UTC,2009-06-30 03:51:48 UTC,Q14721,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient","",">Potassium voltage-gated channel subfamily B member 1 MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLL EVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQK KEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNT LPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLT ESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVF FAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKW TKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAAQSKPKEEL EMESIPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLTSLPSKTGGSTAPEVGWRGAL GASGGRFVEANPSPDASQHSSFFIESPKSSMKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGS AAAAVAGLECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEGQLLYSV DSSPPKSLPGSTSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPD VRVLPGGGAHGSTRDQSI",KCNB1,Voltage-gated potassium channel subunit Kv2.1; h-DRK1,858,95879,8.17,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra PF03521:Kv2channel",HGNC:6231,Membrane,,"","",None,"187-208 229-250 261-282 295-316 331-352 393-414",Non Essential,"",KCNB1,KCNB1,AL035685,Chromosome:20,20q13.2 619,Potassium voltage-gated channel subfamily B member 2,2009-05-26 18:48:49 UTC,2009-06-30 03:51:36 UTC,Q92953,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient","",">Potassium voltage-gated channel subfamily B member 2 MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTH ESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQAR YHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIAL SLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVT IFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFS SLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNF SEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPS RWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDC QEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQ MKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSP KSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLG TEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSD GRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETS M",KCNB2,Voltage-gated potassium channel subunit Kv2.2,911,102564,6.04,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra PF03521:Kv2channel",HGNC:6232,Membrane,,"","",None,"191-212 233-253 264-284 299-320 335-355 396-416",Non Essential,"",KCNB2,KCNB2,U69962,"","" 620,Potassium voltage-gated channel subfamily C member 1,2009-05-26 18:49:12 UTC,2009-06-30 03:51:43 UTC,P48547,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient","",">Potassium voltage-gated channel subfamily C member 1 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNY YRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPG DSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLE THERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNI IDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII FLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPL AQEEILEINRAGRKPLRGMSI",KCNC1,Voltage-gated potassium channel subunit Kv3.1; Kv4; NGK2,511,57943,6.56,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6233,Membrane,,"","",None,"191-209 248-267 277-295 309-331 345-366 415-436",Non Essential,"",KCNC1,KCNC1,M96747,Chromosome:11,11p15 621,Potassium voltage-gated channel subfamily C member 2,2009-05-26 18:49:28 UTC,2009-06-30 03:51:37 UTC,Q96PR1,"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly (By similarity)","",">Potassium voltage-gated channel subfamily C member 2 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPPL SPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAF WGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRR LQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDP ALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVV RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLP RKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPI RRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRS RSPIPSIL",KCNC2,Voltage-gated potassium channel Kv3.2,638,70226,8.01,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6234,Membrane,,"","",None,"230-250 284-303 314-334 346-368 382-402 453-473",Non Essential,"",KCNC2,KCNC2,BC111991,Chromosome:12,12q14.1 622,Potassium voltage-gated channel subfamily C member 3,2009-05-26 18:49:44 UTC,2009-06-30 03:51:49 UTC,Q14003,"This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient","",">Potassium voltage-gated channel subfamily C member 3 MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRGPGDRRAEPCP GLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRH PGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGA ANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALF EDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTY VEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVR ILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNI PIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKN KHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPHTHPGLLRGGAGG LGIMGLPPLPAPGEPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGR YSRDRACFLLTDYAPSPDGSIRKATGAPPLPPQDWRKPGPPSFLPDLNANAAAWISP",KCNC3,Voltage-gated potassium channel subunit Kv3.3; KSHIIID,757,80579,6.50,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6235,Membrane,,"","",None,"291-309 351-370 380-398 412-434 448-469 518-539",Non Essential,"",KCNC3,KCNC3,Z11585,Chromosome:19,19q13.3-q13.4 623,Potassium voltage-gated channel subfamily D member 1,2009-05-26 18:50:15 UTC,2009-06-30 03:51:39 UTC,Q9NSA2,Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits,"",">Potassium voltage-gated channel subfamily D member 1 MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSE KEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK KENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPC RGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLL VPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG TNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQR ADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGEEQALCVRNRSAFEQQHHHLLHCLEKTTC HEFTDELTFSEALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRRAKRRAIRLANSTASVSRGSMQELD MLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRDFVAAIISIPTPPANTPDESQPSSPGGGGRAGSTLRNS SLGTPCLFPETVKISSL",KCND1,Voltage-gated potassium channel subunit Kv4.1,647,71331,8.51,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6237,Membrane,,"","",None,"185-205 227-247 262-282 292-312 326-346 387-407",Non Essential,"",KCND1,KCND1,BC045659,"","" 624,Potassium voltage-gated channel subfamily G member 2,2009-05-26 18:51:15 UTC,2009-06-30 03:51:35 UTC,Q9UJ96,Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values,"",">Potassium voltage-gated channel subfamily G member 2 MEPWPCSPGGGGGTRARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDDLLRVCDDYDVSRDEFF FDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRREEEAAEARAGPTER GAQGSPARALGPRGRLQRGRRRLRDVVDNPHSGLAGKLFACVSVSFVAVTAVGLCLSTMPDIRAEEERGE CSPKCRSLFVLETVCVAWFSFEFLLRSLQAESKCAFLRAPLNIIDILALLPFYVSLLLGLAAGPGGTKLL ERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTMRRCAREFGLLLLFLCVAMALFAPLVHLAERELGAR RDFSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQ RAASPEPALQEDSTHSATATEDSSQGPDSAGLADDSADALWVRAGR",KCNG2,Voltage-gated potassium channel subunit Kv6.2; Cardiac potassium channel subunit,466,51240,9.09,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6249,Membrane,,"","",None,"178-198 218-238 253-273 288-308 322-342 385-405",Non Essential,"",KCNG2,KCNG2,AJ011021,Chromosome:18,18q22-q23 625,Potassium voltage-gated channel subfamily G member 4,2009-05-26 18:51:37 UTC,2009-06-30 03:51:38 UTC,Q8TDN1,Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values,"",">Potassium voltage-gated channel subfamily G member 4 MPMPSRDGGLHPRHHHYGSHSPWSQLLSSPMETPSIKGLYYRRVRKVGALDASPVDLKKEILINVGGRRY LLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCA LSFQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLHREDVLRQQRETRRPASHSSRWGLCMNRLREM VENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLR FVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRL ARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVG YGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELL DPHVASEHELMNDVNDLILEGPALPIMHM",KCNG4,Voltage-gated potassium channel subunit Kv6.4,519,58980,6.67,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:19697,Cell membrane,,"","",None,"119-139 259-279 290-310 335-355 371-391 434-454",Non Essential,"",KCNG4,KCNG4,BC008969,Chromosome:16,16q24.1 626,Potassium voltage-gated channel subfamily H member 3,2009-05-26 18:51:56 UTC,2009-06-30 03:51:50 UTC,Q9ULD8,Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly,"",">Potassium voltage-gated channel subfamily H member 3 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFL YGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRG GPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAI RKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNF RTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLD RYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGG NSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGA LMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQS LPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVL KGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGEL SYNLGAGGGSAEVDTSSLSGDNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSP RRTAPRPRLGGRGRPGRAGALKAEAGPSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFS FRVGQSGPECSSSPSPGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLVL APHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPHPRPGPPPLMAPWPWGPP ASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEEGARTGPAEPVSQAEATSTGEPPPGSGG LALPWDPHSLEMVLIGCHGSGTVQWTQEEGTGV",KCNH3,Voltage-gated potassium channel subunit Kv12.2; Ether-a-go-go-like potassium channel 2; ELK channel 2; ELK2; Brain-specific eag-like channel 1; BEC1,1083,117130,7.98,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08447:PAS_3",HGNC:6252,Membrane,,"","",None,"229-249 260-280 303-323 332-352 362-382 480-500",Non Essential,"",KCNH3,KCNH3,AB022696,Chromosome:12,12q13 627,Potassium voltage-gated channel subfamily H member 4,2009-05-26 18:52:12 UTC,2009-06-30 03:51:41 UTC,Q9UQ05,"Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly","",">Potassium voltage-gated channel subfamily H member 4 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFL YGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSFKDITQSGSPG LGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFGRRGQGGMKANNNVFEPKPSVPEYKVA SVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIIL NFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQK LERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGP SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHS RMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAA SRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEP GLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRF SRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFS ALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEA PSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMGLLQA RLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILP PYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH",KCNH4,Voltage-gated potassium channel subunit Kv12.3; Ether-a-go-go-like potassium channel 1; ELK channel 1; ELK1; Brain-specific eag-like channel 2; BEC2,1017,111695,8.63,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08447:PAS_3",HGNC:6253,Membrane,,"","",None,"229-249 260-280 303-323 333-353 362-382 483-503",Non Essential,"",KCNH4,KCNH4,AB022698,Chromosome:17,17q21.2 628,Potassium voltage-gated channel subfamily H member 8,2009-05-26 18:52:36 UTC,2009-06-30 03:51:34 UTC,Q96L42,"Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly","",">Potassium voltage-gated channel subfamily H member 8 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFL FGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKI TPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKS KFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTY VSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQ HSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSA YIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDL KDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCL RSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNAD VKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNG NINKRLPSIVEDEEEEEEGEEEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVS RSNSPKTKQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEP RISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIRLLENVLSPQQPSRFCSL HSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWSVDPSSVGSSPQRTGAHEQNP ADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTLTPLQSISATLSSSVCSSSETSLHLVLPSRS EEGSFSQGTVSSFSLENLPGSWNQEGMASASTKPLENLPLEVVTSTAEVKDNKAINV",KCNH8,Voltage-gated potassium channel subunit Kv12.1; Ether-a-go-go-like potassium channel 3; ELK channel 3; ELK3; ELK1; hElk1,1107,123834,6.97,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08447:PAS_3",HGNC:18864,Membrane,,"","",None,"226-246 256-276 299-319 328-348 358-378 449-469",Non Essential,"",KCNH8,KCNH8,AY053503,"","" 629,Potassium voltage-gated channel subfamily S member 2,2009-05-26 18:53:06 UTC,2009-06-30 03:51:43 UTC,Q9ULS6,Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity),"",">Potassium voltage-gated channel subfamily S member 2 MTGQSLWDVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFY FDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSD QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLP DFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLV VESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTI EKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQ KQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLNDSLR",KCNS2,Voltage-gated potassium channel subunit Kv9.2; Delayed-rectifier K(+) channel alpha subunit 2,477,54238,5.65,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6301,Cell membrane,,"","",None,"188-208 233-253 262-282 293-313 330-350 390-410",Non Essential,"",KCNS2,KCNS2,BC034778,"","" 630,Potassium voltage-gated channel subfamily S member 3,2009-05-26 18:53:30 UTC,2009-06-30 03:51:47 UTC,Q9BQ31,Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity),"",">Potassium voltage-gated channel subfamily S member 3 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFD RNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDV STDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEF QNEDGEVDDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESE DIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDH TSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID VDQCSEDAPEKCHELPYFNIRDIYAQRMHAFITSLSSVGIVVSDPDSTDASSIEDNEDICNTTSLENCTA K",KCNS3,Voltage-gated potassium channel subunit Kv9.3; Delayed-rectifier K(+) channel alpha subunit 3,491,55971,4.67,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: binding Function: protein binding || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00520:Ion_trans PF02214:K_tetra",HGNC:6302,Cell membrane,,"","",None,"186-206 219-239 254-274 288-308 324-344 386-406",Non Essential,"",KCNS3,KCNS3,BC015947,"","" 631,Potassium channel subfamily T member 1,2009-05-26 18:53:45 UTC,2009-06-30 03:51:49 UTC,Q5JUK3,"Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity)","",">Potassium channel subfamily T member 1 MARAKLPRSPSEGKAGPGGAPAGAAAPEEPHGLSPLLPARGGGSVGSDVGQRLPVEDFSLDSSLSQVQVE FYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSS SEINWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWP PLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENL SLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQ TEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKD QDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCE EECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKS FTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAFS GQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADS SALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNS YEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYM EGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRF MQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLD TTPGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSESQISVNVEDCEDTREVK GPWGSRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSER QELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQDEMNDHQNTLSYVLINPPPDTRLEPSDI VYLIRSDPLAHVASSSQSRKSSCSHKLSSCNPETRDETQL",KCNT1,KCa4.1,1230,138345,7.54,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF03493:BK_channel_a PF07885:Ion_trans_2",HGNC:18865,Cell membrane,,"","",None,"98-118 156-176 188-208 214-226 252-272 305-325",Non Essential,"",KCNT1,KCNT1,"","","" 632,DNA,2009-05-26 19:58:58 UTC,2009-06-19 15:15:24 UTC,DNA,"","","","","","","","","","","","","","",,,,,,,,,,, 633,Major prion protein,2009-05-27 20:12:09 UTC,2009-06-30 03:51:48 UTC,P04156,The physiological function of PrP is not known,"",">Major prion protein MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHG GGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIH FGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVV EQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG",PRNP,PrP; PrP27-30; PrP33-35C; ASCR; CD230 antigen,253,27662,9.23,"",Carbohydrate transport and metabolism,"PF00377:Prion PF03991:Prion_octapep",HGNC:9449,Cell membrane,,"","",1-22,None,Non Essential,1QLZ,PRNP,PRNP,S71212,Chromosome:20,20p13 634,Putative testis-specific prion protein,2009-05-27 20:12:50 UTC,2009-06-30 03:51:35 UTC,Q86SH4,"","",">Putative testis-specific prion protein MQHSLVFFFAVILHLSHLLHLDASIHPFRLPFSSKPFLLIPMSNTTLPHTAWPLSFLHQTVSTLKAVAVT HSLWHLQIPVDCQACNRKSKKIYC",PRNT,Protein M8,94,10756,10.00,"","","",HGNC:18046,Secreted (Potential),,"","",1-18,None,Non Essential,"",PRNT,PRNT,CH471133,Chromosome:20,20p13 635,"Aconitate hydratase, mitochondrial",2009-05-27 20:23:50 UTC,2009-06-30 03:51:41 UTC,Q99798,Citrate = isocitrate,"",">Aconitate hydratase, mitochondrial MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLSEKIV YGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDL RRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGG ADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGM ATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHIN GPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGS EQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFV TSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPKDSSGQHVDVSP TSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKAN SVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLK KQGLLPLTFADPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGS ALNRMKELQQ",ACO2,Aconitase; Citrate hydro-lyase,780,85426,7.65,">>> Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: aconitate hydratase activity Function: catalytic activity Function: lyase activity || >>> Process: cellular metabolism Process: generation of precursor metabolites and energy Process: energy derivation by oxidation of organic compounds Process: main pathways of carbohydrate metabolism Process: tricarboxylic acid cycle Process: physiological process Process: metabolism || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: mitochondrion",Energy production and conversion,"PF00330:Aconitase PF00694:Aconitase_C",HGNC:118,Mitochondrion (By similarity),,"","",None,None,Non Essential,1B0J,ACO2,ACO2,BC026196,Chromosome:22,22q11.2-q13.31|22q13.2|22q13.2-q13.31 636,Cytoplasmic aconitate hydratase,2009-05-27 20:27:28 UTC,2009-06-30 03:51:38 UTC,P21399,"Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. This protein also expresses aconitase activity","",">Cytoplasmic aconitate hydratase MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQ HKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQ KNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTM IDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEF FGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPS QDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNT EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPY LSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAY AIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPS DKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRG LTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLA GKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIP ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK",ACO1,Aconitase; Citrate hydro-lyase; Iron-responsive element-binding protein 1; IRE-BP 1; Iron regulatory protein 1; IRP1; Ferritin repressor protein,889,98400,6.66,">>> Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: aconitate hydratase activity Function: binding Function: nucleic acid binding Function: RNA binding Function: catalytic activity Function: lyase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Energy production and conversion,"PF00330:Aconitase PF00694:Aconitase_C",HGNC:117,Cytoplasm,,"","",None,None,Non Essential,"",ACO1,ACO1,M58510,"","" 637,Iron-responsive element-binding protein 2,2009-05-27 20:31:52 UTC,2009-06-30 03:51:42 UTC,P48200 ,"Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA","",">Iron-responsive element-binding protein 2 MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKKEDVMNILDWK TKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQ NAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQPVPE PETVLKNQEVEFGRNRERLQFFKWSSRVLKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTD SHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAG KFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRN DQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSI HYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSS GVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPP LVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNS LEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKY LTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIP LIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETF SLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS",IREB2,IRE-BP 2; Iron regulatory protein 2; IRP2,963,105014,7.05,">>> Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: aconitate hydratase activity Function: binding Function: nucleic acid binding Function: RNA binding Function: catalytic activity Function: lyase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Energy production and conversion,"PF00330:Aconitase PF00694:Aconitase_C",HGNC:6115,Cytoplasm,,"","",None,None,Non Essential,"",IREB2,IREB2,U20180,Chromosome:15,15q25.1 638,Muscarinic acetylcholine receptor M1,2009-05-28 20:44:58 UTC,2009-06-30 03:51:47 UTC,P11229,"The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover","",">Muscarinic acetylcholine receptor M1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACA DLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPR RAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWR IYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEE DEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLA KRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC",CHRM1,"",460,51421,9.67,">>> Function: amine receptor activity Function: muscarinic acetylcholine receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:1950,Cell membrane,,"","",None,"25-47 62-82 100-121 142-164 187-209 367-387 402-421",Non Essential,"",CHRM1,CHRM1,BC022984,Chromosome:11,11q13 639,Muscarinic acetylcholine receptor M2,2009-05-28 20:46:38 UTC,2009-06-30 03:51:42 UTC,P08172,"The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition","",">Muscarinic acetylcholine receptor M2 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADL IIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMA GMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHIS RASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEK ESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSS GQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR",CHRM2,"",466,51716,9.08,">>> Function: amine receptor activity Function: muscarinic acetylcholine receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:1951,Cell membrane,,"","",None,"23-45 60-80 98-119 140-162 185-207 389-409 424-443",Non Essential,"",CHRM2,CHRM2,AB041391,"","" 640,Muscarinic acetylcholine receptor M3,2009-05-28 20:46:54 UTC,2009-06-30 03:51:44 UTC,P20309,"The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover","",">Muscarinic acetylcholine receptor M3 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVF IAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLA CDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYF VGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENF VHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSA SSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAA QTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLL CQCDKKKRRKQQYQQRQSVIFHKRAPEQAL",CHRM3,"",590,66129,9.62,">>> Function: amine receptor activity Function: muscarinic acetylcholine receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:1952,Cell membrane,,"","",None,"68-91 105-125 143-164 185-207 230-252 493-513 528-547",Non Essential,"",CHRM3,CHRM3,AF279779,"","" 641,Muscarinic acetylcholine receptor M4,2009-05-28 20:47:16 UTC,2009-06-30 03:51:38 UTC,P08173,"The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase","",">Muscarinic acetylcholine receptor M4 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYF LFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTY PARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVI MTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPAL PPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTG NECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR",CHRM4,"",479,53050,10.34,">>> Function: amine receptor activity Function: muscarinic acetylcholine receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:1953,Cell membrane,,"","",None,"32-54 69-89 107-128 149-171 194-216 402-422 437-456",Non Essential,"",CHRM4,CHRM4,BC119817,Chromosome:11,11p12-p11.2 642,Muscarinic acetylcholine receptor M5,2009-05-28 20:47:38 UTC,2009-06-30 03:51:36 UTC,P08912,"The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover","",">Muscarinic acetylcholine receptor M5 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLL SLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRA KRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMT ILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTST TGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAE TEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTV NPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP",CHRM5,"",532,60074,9.64,">>> Function: amine receptor activity Function: muscarinic acetylcholine receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:1954,Cell membrane,,"","",None,"30-53 67-87 105-126 147-169 192-214 444-464 479-498",Non Essential,"",CHRM5,CHRM5,AF385591,Chromosome:15,15q26 643,Neuropathy target esterase,2009-05-28 21:10:47 UTC,2009-06-30 03:51:43 UTC,Q8IY17,"Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy","",">Neuropathy target esterase MGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGAQPVPFVPQVLGVMIGAGVAVVVTAVLILLV VRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKIL RIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQG DYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAAR DSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPT RTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGLQ GGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGR QTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAED VCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVR QMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRA TTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLGVPPHSELTNPA SNLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGASALDSIQEFRLSGWLAQQEDAH RIVLYQTDASLTPWTVRCLRQADCILIVGLGDQEPTLGQLEQMLENTAVRALKQLVLLHREEGAGPTRTV EWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGAR GCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTS MFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDG HLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEI QSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWSRGNVIEKMLTD RRSTDLNESRRADVLAFPSSGFTDLAEIVSRIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGS PEGASPSTASEMEEEKSILRQRRCLPQEPPGSATDA",PNPLA6,Patatin-like phospholipase domain-containing protein 6,1366,149997,7.85,">>> Function: molecular function unknown || >>> Process: physiological process Process: metabolism Process: primary metabolism Process: lipid metabolism || >>> Component: Not Available","","PF00027:cNMP_binding PF01734:Patatin",HGNC:16268,Endoplasmic reticulum membrane,,"","",None,51-71,Non Essential,"",PNPLA6,PNPLA6,AL050362,Chromosome:19,19p13.3-p13.2 644,Cannabinoid receptor 1,2009-05-28 21:14:48 UTC,2009-06-30 03:51:41 UTC,P21554,Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding,"",">Cannabinoid receptor 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQL VPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCV ILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLT AIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWI GVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILV VLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL",CNR1,CB1; CB-R; CANN6,472,52859,8.25,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: cannabinoid receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:2159,Cell membrane,,"","",None,"117-142 155-175 188-212 233-255 274-299 345-365 378-399",Non Essential,"",CNR1,CNR1,BC100971,"","" 645,RNA,2009-05-29 16:18:09 UTC,2009-06-19 15:15:33 UTC,RNA,"","","","","","","","","","","","","","",,,,,,,,,,, 646,Amyloid beta A4 protein,2009-05-29 17:11:18 UTC,2009-06-30 03:51:43 UTC,P05067,"The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis","",">Amyloid beta A4 protein MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGIL QYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQER MDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWW GGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTT ESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL KTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHV FNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQD EVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVP ANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKG AIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN",APP,Alzheimer disease amyloid protein; ABPP; APPI; APP; PreA4; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; Contains: RecName: Soluble APP-alpha; S-APP-alpha; Contains: RecName: Soluble APP-beta; S-APP-beta; Contains: RecName: C99; Contains: RecName: Beta-amyloid protein 42; Beta-APP42; Contains: RecName: Beta-amyloid protein 40; Beta-APP40; Contains: RecName: C83; Contains: RecName: P3(42); Contains: RecName: P3(40); Contains: RecName: Gamma-secretase C-terminal fragment 59; Gamma-CTF(59); Amyloid intracellular domain 59; AICD-59; AID(59); Contains: RecName: Gamma-secretase C-terminal fragment 57; Gamma-CTF(57); Amyloid intracellular domain 57; AICD-57; AID(57); Contains: RecName: Gamma-secretase C-terminal fragment 50; Gamma-CTF(50); Amyloid intracellular domain 50; AICD-50; AID(50); Contains: RecName: C31,770,86944,4.45,">>> Function: enzyme regulator activity Function: enzyme inhibitor activity Function: protease inhibitor activity Function: endopeptidase inhibitor activity Function: serine-type endopeptidase inhibitor activity Function: binding || >>> Process: Not Available || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02177:A4_EXTRA PF03494:Beta-APP PF00014:Kunitz_BPTI",HGNC:620,Membrane,,REACT_604-Hemostasis;,"",1-17,700-723,Non Essential,1RW6,APP,APP,S61383,Chromosome:21,21q21.2|21q21.3 647,Serum paraoxonase/arylesterase 1,2009-05-29 17:44:27 UTC,2009-06-30 03:51:39 UTC,P27169,Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. May mediate an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation,"",">Serum paraoxonase/arylesterase 1 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDMEILPNGLAFISSGLK YPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKST VELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSP SEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDL WVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKA LYCEL",PON1,PON 1; Serum aryldialkylphosphatase 1; A-esterase 1; Aromatic esterase 1; K-45,355,39750,4.89,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: carboxylic ester hydrolase activity Function: arylesterase activity || >>> Process: Not Available || >>> Component: extracellular region","",PF01731:Arylesterase,HGNC:9204,"Secreted, extracellular space",,"","",None,None,Non Essential,"",PON1,PON1,BC074719,"","" 648,Serum paraoxonase/arylesterase 2,2009-05-29 17:44:52 UTC,2009-06-30 03:51:36 UTC,Q15165,"Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters (By similarity). Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis","",">Serum paraoxonase/arylesterase 2 MGAWVGCGLAGDRAGFLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVGLK FPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTV EIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPN EVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIW VGCHPNGQKLFVYDPNNPPSSEVLRIQNILCEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRAL YCEL",PON2,PON 2; Serum aryldialkylphosphatase 2; A-esterase 2; Aromatic esterase 2,354,39398,5.21,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: carboxylic ester hydrolase activity Function: arylesterase activity || >>> Process: Not Available || >>> Component: extracellular region","",PF01731:Arylesterase,HGNC:9205,Membrane,,"","",None,None,Non Essential,"",PON2,PON2,BC040010,"","" 649,Serum paraoxonase/lactonase 3,2009-05-29 17:45:29 UTC,2009-06-30 03:51:35 UTC,Q15166,Has very limited arylesterase and no paraoxonase activities but rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity),"",">Serum paraoxonase/lactonase 3 MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPSGLAFISSGLK YPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGGFDKELFNPHGISIFIDKDNTVYLYVVNHPHMKSTV EIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYATRDHYFTNSLLSFFEMILDLRWTYVLFYSPR EVKVVAKGFCSANGITVSADQKYVYVADVAAKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDIL AGCHPNPMKLLNYNPEDPPGSEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTL YCEL",PON3,"",354,39608,5.10,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: carboxylic ester hydrolase activity Function: arylesterase activity || >>> Process: Not Available || >>> Component: extracellular region","",PF01731:Arylesterase,HGNC:9206,"Secreted, extracellular space (By similarity)",,"","",None,None,Non Essential,"",PON3,PON3,L48516,"","" 650,Glucose-6-phosphate 1-dehydrogenase,2009-05-29 17:50:43 UTC,2009-06-30 03:51:36 UTC,P11413,Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power,"",">Glucose-6-phosphate 1-dehydrogenase MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTFIVGY ARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNALHLGSQANRLFYL ALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKEMVQN LMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTN SDDVRDEKVKVLKCISEVQANNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWD GVPFILRCGKALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSRGPT EADELMKRVGFQYEGTYKWVNPHKL",G6PD,G6PD,515,59257,6.84,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on CH-OH group of donors Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function: glucose-6-phosphate 1-dehydrogenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: alcohol metabolism Process: monosaccharide metabolism Process: hexose metabolism Process: glucose metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,"PF02781:G6PD_C PF00479:G6PD_N",HGNC:4057,"",,"","",None,None,Non Essential,1QKI,G6PD,G6PD,S64462,"","" 651,O-acetyltransferase,2009-05-29 19:19:57 UTC,2009-06-30 03:51:41 UTC,Q8WZ77,"","",">O-acetyltransferase MAALAYNLGKREINHYFSVRSAKVLALVAVLLLAACHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCM MHKYKISEAKNCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKTASVKVDFLWHPEV NGSMKQCIKVWTEDSIAKPHVIVAGAATWSIKIHNGSSEALSQYKMNITSIAPLLEKLAKTSDVYWVLQD PVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRNSKSNVKMFSVSKLIAQETIMESLDGLHLPESSRE TTAMILMNVYCNKILKPVDGSCCQPRPPVTLIQKLAACFFTLSIIGYLIFYIIHRNAHRKNKPCTDLESG EEKKNIINTPVSSLEILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNENT KETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFGIYRV CQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQIIQKKANGNCFWHFGLLLKLGFL LLFICFLAYSQGAFEKIFSLWPLSKCFELKGNVYEWWFRWRLDRYVFFHGMLFAFIYLALQKRQILSEGK GEPLFSNKISNFLLFISVVSFLTYSIWASSCKNKAECNELHPSVSVVQILAFILIRNIPGYARSVYSSFF AWFGKISLELFICQYHIWLAADTRGILVLIPGNPMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSS LLKRLACIAAFFCGLLILSSIQDKSKH",CAS1,"",797,91729,9.02,"","",PF07779:Cas1p,HGNC:16014,"",,"","",None,None,Non Essential,"",CAS1,CAS1,AF355594,"","" 652,Proteasome subunit beta type-5,2009-06-01 16:30:24 UTC,2009-06-30 03:51:37 UTC,P28074,"The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens","",">Proteasome subunit beta type-5 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHG VIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASK LLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQ AYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP",PSMB5,Proteasome epsilon chain; Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome subunit X; Proteasome chain 6; Proteasome subunit MB1,263,28481,6.94,">>> Function: threonine endopeptidase activity Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis Process: proteolysis during cellular protein catabolism Process: modification-dependent protein catabolism Process: ubiquitin-dependent protein catabolism || >>> Component: proteasome complex (sensu Eukaryota) Component: proteasome core complex (sensu Eukaryota) Component: protein complex Component: proteasome complex (sensu Eukaryota) Component: proteasome core complex (sensu Eukaryota)","Posttranslational modification, protein turnover, chaperones",PF00227:Proteasome,HGNC:9542,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1IRU,PSMB5,PSMB5,S74378,Chromosome:14,14q11.2 653,Acetylcholine receptor subunit alpha,2009-06-01 20:36:04 UTC,2009-06-30 03:51:43 UTC,P02708,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Acetylcholine receptor subunit alpha MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIV TTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNN ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYL PTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST HVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG",CHRNA1,"",482,54546,6.15,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1955,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-20,"256-280 288-306 322-341 454-472",Non Essential,"",CHRNA1,CHRNA1,X70108,"","" 654,Acetylcholine receptor subunit beta,2009-06-01 20:36:38 UTC,2009-06-30 03:51:45 UTC,P11230,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Acetylcholine receptor subunit beta MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKD EEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVR WQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEI IHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLS IFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIF IHKLPLYLRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFI DGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDA TYHLPPPDPFP",CHRNB1,"",501,56699,5.60,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1961,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-23,"245-269 277-295 311-332 470-488",Non Essential,"",CHRNB1,CHRNB1,BC011371,Chromosome:17,17p13.1 655,Acetylcholine receptor subunit delta,2009-06-01 20:37:12 UTC,2009-06-30 03:51:45 UTC,Q07001,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Acetylcholine receptor subunit delta MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVE ETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVY WLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGE WEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSV AISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKL FLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFL QGVYNQPPPQPFPGDPYSYNVQDKRFI",CHRND,"",517,58896,6.52,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1965,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-21,"246-270 278-299 312-333 472-490",Non Essential,"",CHRND,CHRND,BC093925,"","" 656,Acetylcholine receptor subunit epsilon,2009-06-01 20:37:35 UTC,2009-06-30 03:51:38 UTC,Q04844,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Acetylcholine receptor subunit epsilon MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETL TTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLP PAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFC PGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVL LAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELL PRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEV RCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLPYAPC IQP",CHRNE,"",493,54698,4.91,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1966,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-20,"240-264 273-291 307-328 457-480",Non Essential,"",CHRNE,CHRNE,AF105999,Chromosome:17,17p13-p12 657,Acetylcholine receptor subunit gamma,2009-06-01 20:37:57 UTC,2009-06-30 03:51:42 UTC,P07510,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Acetylcholine receptor subunit gamma MHGGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREE ALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYW LPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQH RPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINV LLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRL LPQLLRMHVRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKGP ELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLSLFICGTAG IFLMAHYNRVPALPFPGDPRPYLPSPD",CHRNG,"",517,57884,6.18,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1967,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-22,"241-265 275-293 309-330 475-495",Non Essential,"",CHRNG,CHRNG,AC092165,"","" 658,Cytochrome P450 2C19,2009-06-05 17:03:31 UTC,2009-06-30 03:51:41 UTC,P33261,"Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine","",">Cytochrome P450 2C19 MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFG LERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVST PWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDA VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV",CYP2C19,(R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC19; P450-11A; Mephenytoin 4-hydroxylase; CYPIIC17; P450-254C,490,55932,7.42,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2621,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,1R9O,CYP2C19,CYP2C19,L39102,Chromosome:10,10q24.1-q24.3 659,Cytochrome P450 2D6,2009-06-05 17:12:31 UTC,2009-06-30 03:51:42 UTC,P10635,"Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants","",">Cytochrome P450 2D6 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFS LQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLR NLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQ EGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEME KAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPY ELCAVPR",CYP2D6,CYPIID6; P450-DB1; Debrisoquine 4-hydroxylase,497,55770,7.26,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2625,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP2D6,CYP2D6,BC075024,Chromosome:22,22q13.1 660,Dopamine beta-hydroxylase,2009-06-05 18:06:29 UTC,2009-06-30 03:51:38 UTC,P09172,Conversion of dopamine to noradrenaline,"",">Dopamine beta-hydroxylase MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQE AIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQLLQVQRTP EGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSD ACTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFS GPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIR LYYTAKLRRFNAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKV VTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMCVN YVHYYPQTQLELCKSAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSFNRDVLKALYSFAP ISMHCNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQGRSPAGPTVVSIGGGKG",DBH,Dopamine beta-monooxygenase; Contains: RecName: Soluble dopamine beta-hydroxylase,617,69066,6.39,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen Function: dopamine beta-monooxygenase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: copper ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: amino acid derivative metabolism Process: biogenic amine metabolism Process: catecholamine metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: histidine family amino acid metabolism Process: histidine metabolism Process: histidine catabolism || >>> Component: Not Available","","PF03712:Cu2_monoox_C PF01082:Cu2_monooxygen PF03351:DOMON",HGNC:2689,"Cytoplasmic vesicle, secretory vesicle membrane",,"","",None,17-37,Non Essential,"",DBH,DBH,AL365494,"","" 661,Glutamine synthetase,2009-06-05 18:19:48 UTC,2009-06-30 03:51:36 UTC,P15104,ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine,"",">Glutamine synthetase MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQS EGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLM GTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCE GISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKR HQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFS VTEALIRTCLLNETGDEPFQYKN",GLUL,GS; Glutamate--ammonia ligase,373,42065,6.88,">>> Function: acid-ammonia (or amide) ligase activity Function: catalytic activity Function: ligase activity Function: ligase activity, forming carbon-nitrogen bonds Function: acid-ammonia (or amide) ligase activity Function: ammonia ligase activity Function: glutamate-ammonia ligase activity || >>> Process: nitrogen compound metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: glutamine family amino acid metabolism Process: glutamine metabolism Process: glutamine biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,"PF00120:Gln-synt_C PF03951:Gln-synt_N",HGNC:4341,Cytoplasm,,"","",None,None,Non Essential,"",GLUL,GLUL,BC051726,"","" 662,Cytochrome P450 1B1,2009-06-08 17:43:14 UTC,2009-06-30 03:51:38 UTC,Q16678,Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development,"",">Cytochrome P450 1B1 MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAA HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEH WKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCF GCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHC ESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYP DVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQ CDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ",CYP1B1,CYPIB1,543,60847,9.23,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2597,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP1B1,CYP1B1,AF171066,"","" 663,Fatty-acid amide hydrolase,2009-06-09 20:15:27 UTC,2009-07-22 22:36:14 UTC,O00519,"Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates","",">Fatty-acid amide hydrolase 1 MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLD SEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVS LKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKS SKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSV GPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETK QSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAF LVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGA VSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEEL CLRFMREVERLMTPEKQSS",FAAH,Oleamide hydrolase 1; Anandamide amidohydrolase 1,579,63067,7.72,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Function: amidase activity || >>> Process: Not Available || >>> Component: Not Available","Translation, ribosomal structure and biogenesis",PF01425:Amidase,HGNC:3553,Intracytoplasmic membrane,,"","",None,9-29,Non Essential,"",FAAH,FAAH,BC111941,"","" 664,Fatty-acid amide hydrolase 2,2009-06-09 20:15:50 UTC,2009-06-30 03:51:38 UTC,Q6GMR7,"Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates","",">Fatty-acid amide hydrolase 2 MAPSFTARIQLFLLRALGFLIGLVGRAALVLGGPKFASKTPRPVTEPLLLLSGMQLAKLIRQRKVKCIDV VQAYINRIKDVNPMINGIVKYRFEEAMKEAHAVDQKLAEKQEDEATLENKWPFLGVPLTVKEAFQLQGMP NSSGLMNRRDAIAKTDATVVALLKGAGAIPLGITNCSELCMWYESSNKIYGRSNNPYDLQHIVGGSSGGE GCTLAAACSVIGVGSDIGGSIRMPAFFNGIFGHKPSPGVVPNKGQFPLAVGAQELFLCTGPMCRYAEDLA PMLKVMAGPGIKRLKLDTKVHLKDLKFYWMEHDGGSFLMSKVDQDLIMTQKKVVVHLETILGASVQHVKL KKMKYSFQLWIAMMSAKGHDGKEPVKFVDLLGDHGKHVSPLWELIKWCLGLSVYTIPSIGLALLEEKLRY SNEKYQKFKAVEESLRKELVDMLGDDGVFLYPSHPTVAPKHHVPLTRPFNFAYTGVFSALGLPVTQCPLG LNAKGLPLGIQVVAGPFNDHLTLAVAQYLEKTFGGWVCPGKF",FAAH2,Oleamide hydrolase 2; Anandamide amidohydrolase 2; Amidase domain-containing protein,532,58304,9.51,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Function: amidase activity || >>> Process: Not Available || >>> Component: Not Available","Translation, ribosomal structure and biogenesis",PF01425:Amidase,HGNC:26440,Membrane,,"","",None,11-31,Non Essential,"",FAAH2,FAAH2,BC073922,"","" 665,Prothrombin,2009-06-09 20:36:05 UTC,2009-06-30 03:51:35 UTC,P00734,"Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing","",">Prothrombin MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEA FEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKP EINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPL EQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKP GDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDK TERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAA SLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKR GDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE",F2,Coagulation factor II; Contains: RecName: Activation peptide fragment 1; Contains: RecName: Activation peptide fragment 2; Contains: RecName: Thrombin light chain; Contains: RecName: Thrombin heavy chain,622,70037,5.70,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: thrombin activity Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity || >>> Process: organismal physiological process Process: regulation of body fluids Process: hemostasis Process: blood coagulation Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis || >>> Component: extracellular region","","PF00594:Gla PF00051:Kringle PF00089:Trypsin",HGNC:3535,"Secreted, extracellular space",,REACT_604-Hemostasis;,"",1-24,None,Non Essential,1HAG,F2,F2,V00595,Chromosome:11,11p11 666,Carbonic anhydrase 9,2009-06-10 00:13:12 UTC,2009-06-30 03:51:35 UTC,Q16790,Reversible hydration of carbon dioxide. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia,"",">Carbonic anhydrase 9 MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEED SPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSH WRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGL EMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLE EGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVM LSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA",CA9,Carbonic anhydrase IX; CA-IX; CAIX; Carbonate dehydratase IX; Membrane antigen MN; P54/58N; Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; pMW1,459,49698,4.36,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1383,"Nucleus. Nucleus, nucleolus. Cell membrane",,"","",1-37,415-435,Non Essential,"",CA9,CA9,BC014950,"","" 667,Carbonic anhydrase 12,2009-06-10 00:13:59 UTC,2009-06-30 03:51:39 UTC,O43570,Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 12 MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDAS LTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHF AAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEEL LPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKF DERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMET EAHA",CA12,Carbonic anhydrase XII; CA-XII; Carbonate dehydratase XII; HOM-RCC-3.1.3 tumor antigen,354,39451,7.24,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1371,Membrane,,"","",1-24,302-322,Non Essential,1JD0,CA12,CA12,BC023981,Chromosome:15,15q22 668,Carbonic anhydrase 14,2009-06-10 00:14:37 UTC,2009-06-30 03:51:34 UTC,Q9ULX7,Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 14 MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYD QPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYD SDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYF RYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQ AGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA",CA14,Carbonic anhydrase XIV; CA-XIV; Carbonate dehydratase XIV,337,37668,6.34,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1372,Membrane,,"","",1-15,291-311,Non Essential,"",CA14,CA14,BC034412,"","" 669,"Carbonic anhydrase 5A, mitochondrial",2009-06-10 00:17:30 UTC,2009-06-30 03:51:34 UTC,P35218,Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 5A, mitochondrial MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQ WRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGG SEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARA AMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNN YRPLQPLMNRKVWASFQATNEGTRS",CA5A,Carbonic anhydrase VA; CA-VA; Carbonate dehydratase VA,305,34751,7.68,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1377,Mitochondrion,,"","",None,None,Non Essential,"",CA5A,CA5A,S80181,Chromosome:16,16q24.3 670,"Carbonic anhydrase 5B, mitochondrial",2009-06-10 00:18:16 UTC,2009-06-30 03:51:44 UTC,Q9Y2D0,Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 5B, mitochondrial MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIR WRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWG SEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALV EFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDN FRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP",CA5B,Carbonic anhydrase VB; CA-VB; Carbonate dehydratase VB,317,36434,7.91,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1378,Mitochondrion,,"","",None,None,Non Essential,"",CA5B,CA5B,BC028142,"","" 671,Carbonic anhydrase 6,2009-06-10 00:19:52 UTC,2009-06-30 03:51:49 UTC,P23280,Reversible hydration of carbon dioxide. Its role in saliva is unknown,"",">Carbonic anhydrase 6 MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTG YETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIV HYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQ HYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPN QEYTLGSEFQFYLHKIEEILDYLRRALN",CA6,Carbonic anhydrase VI; CA-VI; Carbonate dehydratase VI; Secreted carbonic anhydrase; Salivary carbonic anhydrase,308,35367,7.03,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1380,Secreted,,"","",1-17,None,Non Essential,"",CA6,CA6,AL139415,"","" 672,Carbonic anhydrase 7,2009-06-10 00:20:21 UTC,2009-06-30 03:51:48 UTC,P43166,Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 7 MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQV DFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAP DGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVT WIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA",CA7,Carbonic anhydrase VII; CA-VII; Carbonate dehydratase VII,264,29659,7.45,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1381,Cytoplasm (Probable),,"","",None,None,Non Essential,"",CA7,CA7,BC033865,Chromosome:16,16q22.1 673,Carbonic anhydrase 13,2009-06-10 00:21:04 UTC,2009-06-30 03:51:35 UTC,Q8N1Q1,Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 13 MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVD FDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPD GLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTW IVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH",CA13,Carbonic anhydrase XIII; CA-XIII; Carbonate dehydratase XIII,262,29443,6.97,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:14914,"",,"","",None,None,Non Essential,"",CA13,CA13,BC052602,"","" 674,UDP-glucuronosyltransferase 1-6,2009-06-10 16:07:31 UTC,2009-06-30 03:51:34 UTC,P19224,UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols,"",">UDP-glucuronosyltransferase 1-6 MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKES KYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFK ESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVA NFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCK KRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTIL VKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV IGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH",UGT1A6,UDP-glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; UGT-1F; UGT1F; Phenol-metabolizing UDP-glucuronosyltransferase,532,60751,8.55,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring hexosyl groups || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00201:UDPGT,HGNC:12538,Microsome. Endoplasmic reticulum membrane,,"","",1-26,490-506,Non Essential,"",UGT1A6,UGT1A6,AF297093,"","" 675,UDP-glucuronosyltransferase 1-3,2009-06-10 16:16:25 UTC,2009-06-30 03:51:38 UTC,P35503,UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds,"",">UDP-glucuronosyltransferase 1-3 MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIK EENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRH LNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQR VKNMLYPLALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGIN CANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNT ILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSL DVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH",UGT1A3,UDP-glucuronosyltransferase 1A3; UDPGT; UGT1*3; UGT1-03; UGT1.3; UGT-1C; UGT1C,534,60339,8.28,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring hexosyl groups || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00201:UDPGT,HGNC:12535,Microsome. Endoplasmic reticulum membrane,,"","",1-28,492-508,Non Essential,"",UGT1A3,UGT1A3,AF297093,"","" 676,Signal transducer and activator of transcription 3,2009-06-10 16:57:33 UTC,2009-06-30 03:51:43 UTC,P40763,Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA,"",">Signal transducer and activator of transcription 3 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSR FLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEK QQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTAL DQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQ IKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVR LLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNV NFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFS FWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISG KTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPG SAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM",STAT3,Acute-phase response factor,770,88069,6.23,">>> Function: signal transducer activity Function: nucleic acid binding Function: DNA binding Function: transcription factor activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00017:SH2 PF01017:STAT_alpha PF02864:STAT_bind PF02865:STAT_int",HGNC:11364,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1BG1,STAT3,STAT3,AF029311,Chromosome:17,17q21.31 677,Tyrosine-protein kinase JAK2,2009-06-10 17:04:36 UTC,2009-06-30 03:51:42 UTC,O60674,"Plays a role in leptin signaling and control of body weight (By similarity). Tyrosine kinase of the non-receptor type, involved in interleukin-3 and probably interleukin-23 signal transduction","",">Tyrosine-protein kinase JAK2 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIA ASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGA EAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFL PKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPS GEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDN IIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIF KGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRH QLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNI VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATR NILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTY IEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA LRVDQIRDNMAG",JAK2,Janus kinase 2; JAK-2,1132,130675,7.21,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein-tyrosine kinase activity Function: receptor signaling protein tyrosine kinase activity Function: Janus kinase activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton","","PF07714:Pkinase_Tyr PF00017:SH2",HGNC:6192,Intracytoplasmic membrane,,"","",None,None,Non Essential,"",JAK2,JAK2,AL161450,"","" 678,Glutathione S-transferase theta-1,2009-06-10 19:58:28 UTC,2009-06-30 03:51:42 UTC,P30711,"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide","",">Glutathione S-transferase theta-1 MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDGDFTLTESVAI LLYLTRKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMFPVFLGEPVSPQTLAATLAEL DVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGAGCQVFEGRPKLATWRQRVEAAVGEDLFQEA HEVILKAKDFPPADPTIKQKLMPWVLAMIR",GSTT1,GST class-theta-1; Glutathione transferase T1-1,240,27335,7.60,"","Posttranslational modification, protein turnover, chaperones","PF00043:GST_C PF02798:GST_N",HGNC:4641,Cytoplasm,,"","",None,None,Non Essential,"",GSTT1,GSTT1,BC007065,Chromosome:22,22q11.23 679,"Solute carrier family 2, facilitated glucose transporter member 1",2009-06-10 20:11:10 UTC,2009-06-30 03:51:39 UTC,P11166,Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses,"",">Solute carrier family 2, facilitated glucose transporter member 1 MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVA IFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFV PMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPES PRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQL SQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAIL MTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGM CFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADS QV",SLC2A1,"Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter",492,54085,8.91,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: transporter activity Function: carbohydrate transporter activity Function: sugar transporter activity Function: monosaccharide transporter activity Function: hexose transporter activity Function: glucose transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:11005,Cell membrane,,"","",None,"13-33 67-87 96-116 127-147 156-176 186-206 272-292 308-328 338-358 372-392 402-422 430-450",Non Essential,"",SLC2A1,SLC2A1,AY034633,"","" 680,"Solute carrier family 2, facilitated glucose transporter member 2",2009-06-10 20:12:16 UTC,2009-06-30 03:51:40 UTC,P11168,Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney,"",">Solute carrier family 2, facilitated glucose transporter member 2 MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTI SYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGAL LMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEF ILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKER EEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNM VFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPW FMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGK SFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV",SLC2A2,"Glucose transporter type 2, liver; GLUT-2",524,57490,8.10,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: transporter activity Function: carbohydrate transporter activity Function: sugar transporter activity Function: monosaccharide transporter activity Function: hexose transporter activity Function: glucose transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:11006,Membrane,,"","",None,"11-31 99-119 128-148 159-179 188-208 218-238 304-324 339-359 369-389 401-421 434-454 462-482",Non Essential,"",SLC2A2,SLC2A2,J03810,"","" 681,"Solute carrier family 2, facilitated glucose transporter member 3",2009-06-10 20:14:18 UTC,2009-06-30 03:51:47 UTC,P11169,Facilitative glucose transporter. Probably a neuronal glucose transporter,"",">Solute carrier family 2, facilitated glucose transporter member 3 MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIF SVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPM YIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPR FLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQ QLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMT VSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLF PSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAK ETTTNV",SLC2A3,"Glucose transporter type 3, brain; GLUT-3",496,53925,7.24,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: transporter activity Function: carbohydrate transporter activity Function: sugar transporter activity Function: monosaccharide transporter activity Function: hexose transporter activity Function: glucose transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:11007,Membrane,,"","",None,"6-26 65-85 94-114 125-145 154-174 184-204 270-290 305-325 335-355 369-389 400-420 428-448",Non Essential,"",SLC2A3,SLC2A3,AY034634,Chromosome:12,12p13.3 682,"Solute carrier family 2, facilitated glucose transporter member 4",2009-06-10 20:14:59 UTC,2009-06-30 03:51:46 UTC,P14672,Insulin-regulated facilitative glucose transporter,"",">Solute carrier family 2, facilitated glucose transporter member 4 MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPS SIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLIL GRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTV LPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLG SRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRR TLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAM AVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLL EQEVKPSTELEYLGPDEND",SLC2A4,"Glucose transporter type 4, insulin-responsive; GLUT-4",509,54788,6.94,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: transporter activity Function: carbohydrate transporter activity Function: sugar transporter activity Function: monosaccharide transporter activity Function: hexose transporter activity Function: glucose transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:11009,Intracytoplasmic membrane,,"","",None,"25-45 82-102 112-132 143-163 172-192 202-222 288-308 324-344 354-374 385-405 418-438 446-466",Non Essential,"",SLC2A4,SLC2A4,X58489,Chromosome:17,17p13 683,"Solute carrier family 2, facilitated glucose transporter member 5",2009-06-10 20:17:50 UTC,2009-06-30 03:51:36 UTC,P22732,Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter,"",">Solute carrier family 2, facilitated glucose transporter member 5 MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLL WSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAG VSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLL PFFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLS IIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFS ICLIACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHW LSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEE LKELPPVTSEQ",SLC2A5,"Glucose transporter type 5, small intestine; GLUT-5; Fructose transporter",501,54975,5.85,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: glucose transporter activity Function: transporter activity Function: carbohydrate transporter activity Function: sugar transporter activity Function: monosaccharide transporter activity Function: hexose transporter activity Function: fructose transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:11010,Membrane,,"","",None,"13-33 69-89 99-119 121-141 162-182 193-213 278-298 319-339 343-363 369-389 413-433 440-460",Non Essential,"",SLC2A5,SLC2A5,BC001820,"","" 684,"Solute carrier family 2, facilitated glucose transporter member 6",2009-06-10 20:18:58 UTC,2009-06-30 03:51:37 UTC,Q9UGQ3,Facilitative glucose transporter; binds cytochalasin B with low affinity,"",">Solute carrier family 2, facilitated glucose transporter member 6 MQEPLLGAEGPDYDTFPEKPPPSPGDRARVGTLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPALERSL DPDLHLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRT LTGFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILL LSFMPNSPRFLLSRGRDEEALRALAWLRGTDVDVHWEFEQIQDNVRRQSSRVSWAEARAPHVCRPITVAL LMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRKVLLFVSAAIMF AANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLL MSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRS LEQIESFFRTGRRSFLR",SLC2A6,Glucose transporter type 6; GLUT-6; Glucose transporter type 9; GLUT-9,507,54540,8.77,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:11011,Cell membrane,,"","",None,"38-58 82-102 112-132 141-161 169-189 195-215 290-310 315-335 340-360 396-416 436-456 463-483",Non Essential,"",SLC2A6,SLC2A6,BC013740,"","" 685,"Solute carrier family 2, facilitated glucose transporter member 7",2009-06-10 20:32:57 UTC,2009-06-30 03:51:43 UTC,Q6PXP3,"High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose","",">Solute carrier family 2, facilitated glucose transporter member 7 MENKEAGTPPPIPSREGRLQPTLLLATLSAAFGSAFQYGYNLSVVNTPHKVFKSFYNETYFERHATFMDG KLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSCGRKGTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVV LGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIFSLQAILGNPAGWPVLLALTGVPAL LQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAERAEGHLSVLHLCALRSL RWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHL LLAGYGICGSACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMV DGAVHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEINRIFAKRNRVKLP EEKEETIDAGPPTASPAKETSF",SLC2A7,Glucose transporter type 7; GLUT-7,512,55728,8.52,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: glucose transporter activity Function: transporter activity Function: carbohydrate transporter activity Function: sugar transporter activity Function: monosaccharide transporter activity Function: hexose transporter activity Function: fructose transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Carbohydrate transport and metabolism,"",HGNC:13445,Membrane,,"","",None,"22-42 79-99 108-128 139-159 173-193 199-219 282-302 322-342 351-371 380-400 416-436 446-466",Non Essential,"",SLC2A7,SLC2A7,CH471130,"","" 686,"Solute carrier family 2, facilitated glucose transporter member 8",2009-06-10 20:33:47 UTC,2009-06-30 03:51:47 UTC,Q9NY64,Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity),"",">Solute carrier family 2, facilitated glucose transporter member 8 MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAAS WFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLV APVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPRFLL TQHRRQEAMAALRFLWGSEQGWEDPPIGAEQSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAE TIFEEAKFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNS SHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLM AFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR",SLC2A8,Glucose transporter type 8; GLUT-8; Glucose transporter type X1,477,50820,7.68,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:13812,Cell membrane,,"","",None,"26-46 71-91 97-117 128-148 157-177 183-203 257-277 293-313 320-340 368-388 405-425 439-459",Non Essential,"",SLC2A8,SLC2A8,AJ245937,"","" 687,"Solute carrier family 2, facilitated glucose transporter member 9",2009-06-10 21:12:54 UTC,2009-06-30 03:51:43 UTC,Q9NRM0,Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate,"",">Solute carrier family 2, facilitated glucose transporter member 9 MARKQNRNSKELGLVPLTDDTSHARPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFL YGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHT LLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFIC IGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKA DVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPL AKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGIL AIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICIT GAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP",SLC2A9,Glucose transporter type 9; GLUT-9,540,58818,9.24,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:13446,Membrane,,"","",None,"52-72 108-128 141-161 172-192 201-221 232-252 317-337 355-375 382-402 416-436 452-472 479-499",Non Essential,"",SLC2A9,SLC2A9,AF421859,"","" 688,"Solute carrier family 2, facilitated glucose transporter member 10",2009-06-10 21:13:30 UTC,2009-06-30 03:51:37 UTC,O95528,Facilitative glucose transporter,"",">Solute carrier family 2, facilitated glucose transporter member 10 MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLID CYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYE AGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLG PGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVK VAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQD SSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFV SAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGL GFIYLFVPETKGQSLAEIDQQFQKRRFTLSFGHRQNSTGIPYSRIEISAAS",SLC2A10,Glucose transporter type 10; GLUT-10,541,56912,8.68,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:13444,Intracytoplasmic membrane,,"","",None,"16-36 49-69 78-98 107-127 135-155 167-187 234-254 270-290 299-319 415-435 446-466 477-497",Non Essential,"",SLC2A10,SLC2A10,BC113423,Chromosome:20,20q13.1 689,"Solute carrier family 2, facilitated glucose transporter member 11",2009-06-10 21:14:07 UTC,2009-06-30 03:51:43 UTC,Q9BYW1,Facilitative glucose transporter (By similarity),"",">Solute carrier family 2, facilitated glucose transporter member 11 MRALRRLIQGRILLLTICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPDHLVLLMWSLI VSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMN IQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGLRELLGGPQAWPLLLASCLVPGALQLASLPLLP ESPRYLLIDCGDTEACLAALRRLRGSGDLAGELEELEEERAACQGCRARRPWELFQHRALRRQVTSLVVL GSAMELCGNDSVYAYASSVFRKAGVPEAKIQYAIIGTGSCELLTAVVSCVVIERVGRRVLLIGGYSLMTC WGSIFTVALCLQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIMLI LVGLGFPFIMEALSHFLYVPFLGVCVCGAIYTGLFLPETKGKTFQEISKELHRLNFPRRAQGPTWRSLEV IQSTEL",SLC2A11,Glucose transporter type 11; GLUT-11; Glucose transporter type 10; GLUT-10,496,53704,8.23,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: transporter activity Function: carbohydrate transporter activity Function: sugar transporter activity Function: monosaccharide transporter activity Function: hexose transporter activity Function: glucose transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:14239,Membrane,,"","",None,"12-32 62-82 98-118 129-149 158-178 188-208 274-294 312-332 339-359 365-385 409-429 436-456",Non Essential,"",SLC2A11,SLC2A11,CR456373,Chromosome:22,22q11.2 690,"Solute carrier family 2, facilitated glucose transporter member 12",2009-06-10 21:14:37 UTC,2009-06-30 03:51:48 UTC,Q8TD20,Facilitative glucose transporter (By similarity),"",">Solute carrier family 2, facilitated glucose transporter member 12 MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQIKT LLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRIAI GVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYISNYAFANVFHGWKYMFGLVIPLGVLQ AIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIM IGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIG SSVMAASLVTMGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM PLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEI FPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLASLLFVVMFIPETKGCSLEQI SMELAKVNYVKNNICFMSHHQEELVPKQPQKRKPQEQLLECNKLCGRGQSRQLSPET",SLC2A12,Glucose transporter type 12; GLUT-12,617,66967,8.46,">>> Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: sugar porter activity Function: transporter activity || >>> Process: carbohydrate transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00083:Sugar_tr,HGNC:18067,Intracytoplasmic membrane,,"","",None,"45-65 81-101 116-136 138-158 173-193 198-218 279-299 318-338 346-366 467-487 499-519 529-549",Non Essential,"",SLC2A12,SLC2A12,BC070149,"","" 692,Phosphorus,2009-06-16 17:50:15 UTC,2009-06-19 15:15:46 UTC,Phosphorus,"","","","","","","","","","","","","","",,,,,,,,,,, 693,"NACHT, LRR and PYD domains-containing protein 3",2009-06-16 20:20:14 UTC,2009-06-30 03:51:41 UTC,Q96P20,May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18,"",">NACHT, LRR and PYD domains-containing protein 3 MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRK YVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPD DEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPD PNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRP VALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGL KQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNH GLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFY CLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLD MVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNI RRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSA CCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLG DLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW",NLRP3,Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1; Angiotensin/vasopressin receptor AII/AVP-like,1034,117915,6.58,"","","PF00560:LRR_1 PF05729:NACHT PF02758:PAAD_DAPIN",HGNC:16400,Cytoplasm,,"","",None,None,Non Essential,"",NLRP3,NLRP3,AF054176,"","" 694,Prostaglandin G/H synthase 1,2009-06-17 15:14:22 UTC,2009-06-30 03:51:48 UTC,P23219,May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells,"",">Prostaglandin G/H synthase 1 MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTI PGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWES FSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFK TSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPP QSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQ LSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAEL EELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKT ATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL",PTGS1,Cyclooxygenase-1; COX-1; Prostaglandin-endoperoxide synthase 1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1,599,68657,7.39,">>> Function: antioxidant activity Function: peroxidase activity || >>> Process: Not Available || >>> Component: Not Available","","PF03098:An_peroxidase PF00008:EGF",HGNC:9604,Microsome membrane,,"","",1-23,None,Non Essential,"",PTGS1,PTGS1,BC029840,"","" 695,Prostaglandin G/H synthase 2,2009-06-17 15:14:42 UTC,2009-06-30 03:51:40 UTC,P35354 ,May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity,"",">Prostaglandin G/H synthase 2 MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPT PNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPP VPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGL GHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGL VPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPE LLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELY PALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKG CPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL",PTGS2,Cyclooxygenase-2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II,604,68997,7.41,">>> Function: antioxidant activity Function: peroxidase activity || >>> Process: Not Available || >>> Component: Not Available","","PF03098:An_peroxidase PF00008:EGF",HGNC:9605,Microsome membrane,,"","",1-17,None,Non Essential,"",PTGS2,PTGS2,BC013734,"","" 696,Putative HIF-prolyl hydroxylase PH-4,2009-06-17 21:36:20 UTC,2009-06-30 03:51:46 UTC,Q9NXG6,"May catalyze the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex","",">Putative HIF-prolyl hydroxylase PH-4 MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAYFLVLMVFVHL YLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSL KPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSTMQVSQLDLFRLLDQNRDGHLQLREV LAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWL YQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANES VPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGTDSQPEWA LDRAYRDARVEL",PH4,Hypoxia-inducible factor prolyl 4-hydroxylase,502,56662,5.99,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","",PF03171:2OG-FeII_Oxy,HGNC:28858,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",PH4,P4HTM,BC060321,"","" 697,Prolyl 4-hydroxylase subunit alpha-1,2009-06-17 21:37:24 UTC,2009-06-30 03:51:41 UTC,P13674,Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins,"",">Prolyl 4-hydroxylase subunit alpha-1 MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTA TKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDT YNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDY LSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAV DYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIE IVKDLAKPRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFA SGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE",P4HA1,"4-PH alpha-1; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1",534,61050,5.84,">>> Function: binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","","PF03171:2OG-FeII_Oxy PF08336:P4Ha_N PF07719:TPR_2",HGNC:8546,Endoplasmic reticulum lumen,,"","",1-17,None,Non Essential,1TJC,P4HA1,P4HA1,BC034998,Chromosome:10,10q21.3-q23.1 698,Prolyl 4-hydroxylase subunit alpha-2,2009-06-17 21:37:42 UTC,2009-06-30 03:51:43 UTC,O15460,Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins,"",">Prolyl 4-hydroxylase subunit alpha-2 MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTS KSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQ DTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVL DYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERP VDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEI ERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVAN YGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLL RSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD",P4HA2,"4-PH alpha-2; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2",535,60903,5.43,">>> Function: binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","","PF03171:2OG-FeII_Oxy PF08336:P4Ha_N PF07719:TPR_2",HGNC:8547,Endoplasmic reticulum lumen,,"","",1-21,None,Non Essential,"",P4HA2,P4HA2,BC035813,"","" 699,Prolyl 4-hydroxylase subunit alpha-3,2009-06-17 21:38:03 UTC,2009-06-30 03:51:48 UTC,Q7Z4N8,Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins,"",">Prolyl 4-hydroxylase subunit alpha-3 MGPGARLAALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYD KVLSLHEDSTTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEKVEQDLPAFEDLEGAARAL MRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSL FRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLYSPDNKRMARNVLKYERLLAESPNH VVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIAL YHDFVSDSEAQKIRELAEPWLQRSVVASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRP PYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMKSGNRVATFMIYLSSVEAGGATAFIYANLSVPVVRN AALFWWNLHRSGEGDSDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPCSSSPED",P4HA3,"4-PH alpha-3; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3",544,61127,6.46,">>> Function: binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","","PF03171:2OG-FeII_Oxy PF08336:P4Ha_N",HGNC:30135,Endoplasmic reticulum lumen (Probable),,"","",1-19,None,Non Essential,"",P4HA3,P4HA3,BC126170,Chromosome:11,11q13.4 700,Protein tyrosine phosphatase type IVA 1,2009-06-18 20:20:50 UTC,2009-06-30 03:51:34 UTC,Q93096,"Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis","",">Protein tyrosine phosphatase type IVA 1 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPF DDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGA FNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ",PTP4A1,Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PRL-1; PTP(CAAXI),173,19815,9.25,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF00102:Y_phosphatase,HGNC:9634,Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Spindle,,"","",None,None,Non Essential,1XM2,PTP4A1,PTP4A1,U69701,"","" 701,Protein tyrosine phosphatase type IVA 2,2009-06-18 20:21:09 UTC,2009-06-30 03:51:47 UTC,Q12974,Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB,"",">Protein tyrosine phosphatase type IVA 2 MNRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDG APPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNS KQLLYLEKYRPKMRLRFRDTNGHCCVQ",PTP4A2,Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2; PTP(CAAXII); HU-PP-1; OV-1,167,19127,8.48,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF00102:Y_phosphatase,HGNC:9635,Cell membrane. Early endosome. Cytoplasm,,"","",None,None,Non Essential,"",PTP4A2,PTP4A2,L39000,"","" 702,Protein tyrosine phosphatase type IVA 3,2009-06-18 20:21:26 UTC,2009-06-30 03:51:43 UTC,O75365,"Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II","",">Protein tyrosine phosphatase type IVA 3 MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPF DDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGA INSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM",PTP4A3,Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3; PRL-R,173,19535,9.63,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF00102:Y_phosphatase,HGNC:9636,Cell membrane. Early endosome,,"","",None,None,Non Essential,1V3A,PTP4A3,PTP4A3,U87168,"","" 703,Tyrosine-protein phosphatase non-receptor type 7,2009-06-18 20:21:57 UTC,2009-06-30 03:51:36 UTC,P35236,Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction,"",">Tyrosine-protein phosphatase non-receptor type 7 MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREV TLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGR AQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPT EEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPET AAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY AGQLPEEPSP",PTPN7,Protein-tyrosine phosphatase LC-PTP; Hematopoietic protein-tyrosine phosphatase; HEPTP,360,40530,6.79,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9659,Cytoplasm,,"","",None,None,Non Essential,"",PTPN7,PTPN7,BC001746,"","" 704,Receptor-type tyrosine-protein phosphatase U,2009-06-18 20:22:23 UTC,2009-06-30 03:51:45 UTC,Q92729 ,"Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Forms complexes with beta-catenin and gamma-catenin/plakoglobin (By similarity)","",">Receptor-type tyrosine-protein phosphatase U MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGS YLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGTGGTLGVYVRVNGGPLASAVWNMTGSHGR QWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCM AAGEPMRQRFLLQRQSGALVPAGAFGTSATGFLATFPLAAVSRAEQDLYRCVSQAPRGGVSNFAELIVKE PPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE ISVLLTRPGDGGTGRWATPHQPHQMRRAHEGPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHY TLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLT FTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLF SVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERAR GCGGTRWTGLLPSAIDLRGGAGPRLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYF QAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPV NMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRR PCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKVKGSRQEPMPAYD RHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRV KCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQSHFTAWPEHGVPYHATGLLAF IRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIF IHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDK NRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRRSAFMVTLHPLQSTTPDFWRLVYDYGCTSIVML NQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGDLLVRHFQFLRWSA YRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAQTLR NYKPNMVETMDQYHFCYDVALEYLEGLESR",PTPRU,R-PTP-U; Protein-tyrosine phosphatase J; PTP-J; Pancreatic carcinoma phosphatase 2; PCP-2,1430,160230,6.76,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: cell Component: membrane","","PF00041:fn3 PF00629:MAM PF00102:Y_phosphatase",HGNC:9683,Membrane,,"","",1-18,741-764,Non Essential,"",PTPRU,PTPRU,X97198,"","" 705,Receptor-type tyrosine-protein phosphatase alpha,2009-06-18 20:22:41 UTC,2009-06-30 03:51:37 UTC,P18433,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Receptor-type tyrosine-protein phosphatase alpha MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLSVAPTFSPNIT LGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSDE TPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSKQAGSHSNSFRLSNGRTEDVEPQSVPLLAR SPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHS RVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKC AQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQ YVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMK KNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIV MLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEV GIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQ RPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK",PTPRA,Protein-tyrosine phosphatase alpha; R-PTP-alpha,802,90601,6.67,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9664,Membrane,,"","",1-19,143-165,Non Essential,1YFO,PTPRA,PTPRA,BC027308,Chromosome:20,20p13 706,Tyrosine-protein phosphatase non-receptor type 11,2009-06-18 20:22:54 UTC,2009-06-30 03:51:46 UTC,Q06124,Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus,"",">Tyrosine-protein phosphatase non-receptor type 11 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEK FATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRES QSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVL QLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYK NILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENS RVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVW QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDC DIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGD QSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR",PTPN11,Protein-tyrosine phosphatase 2C; PTP-2C; PTP-1D; SH-PTP3; SH-PTP2; SHP-2; Shp2,597,68437,7.31,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00017:SH2 PF00102:Y_phosphatase",HGNC:9644,Cytoplasm,,"","",None,None,Non Essential,2SHP,PTPN11,PTPN11,BC008692,Chromosome:12,12q24 707,Tyrosine-protein phosphatase non-receptor type 12,2009-06-18 20:23:35 UTC,2009-06-30 03:51:40 UTC,Q05209,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Tyrosine-protein phosphatase non-receptor type 12 MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPF DHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGR KKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSIL DMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTK EQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMISSIEPEKQDSPPPKPPRTRSCLVEGDAK EEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNE STIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDT SQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINY QTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASAT VSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWS ELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPK GPRDPPSEWT",PTPN12,Protein-tyrosine phosphatase G1; PTPG1; PTP-PEST,780,88121,5.33,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9645,Cytoplasm,,"","",None,None,Non Essential,"",PTPN12,PTPN12,S69184,"","" 708,Tyrosine-protein phosphatase non-receptor type 13,2009-06-18 20:23:52 UTC,2009-06-30 03:51:49 UTC,Q12923,Regulates negatively FAS-induced apoptosis and NGFR- mediated pro-apoptotic signaling,"",">Tyrosine-protein phosphatase non-receptor type 13 MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDEN ISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVI YARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLP TGRSSTSDVLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTS GPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIA LDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQL QAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSI LTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDL KLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSL LLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVC QRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTG SLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYP HRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPG QAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLG IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPV HLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQ VNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSS SQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAV IPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLS DQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQ PAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQV LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALH QTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSM DKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQD PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNK EELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVL KATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIK GSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTE DTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDH SFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRK NRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQ EVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHD TPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGM VQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK",PTPN13,Protein-tyrosine phosphatase 1E; PTP-E1; hPTPE1; PTP-BAS; Protein-tyrosine phosphatase PTPL1; Fas-associated protein-tyrosine phosphatase 1; FAP-1,2485,276908,6.37,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity Function: binding Function: protein binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton","","PF00373:Band_41 PF00595:PDZ PF00102:Y_phosphatase",HGNC:9646,"Cytoplasm, cytoskeleton (By similarity)",,"","",None,None,Non Essential,1WCH,PTPN13,PTPN13,BC039610,"","" 709,Tyrosine-protein phosphatase non-receptor type 1,2009-06-18 20:24:18 UTC,2009-06-30 03:51:42 UTC,P18031,May play an important role in CKII- and p60c-src-induced signal transduction cascades (By similarity),"",">Tyrosine-protein phosphatase non-receptor type 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINAS LIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNL KLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGP VVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKF IMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEK GSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT AGAYLCYRFLFNSNT",PTPN1,Protein-tyrosine phosphatase 1B; PTP-1B,435,49967,6.21,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9642,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,1A5Y,PTPN1,PTPN1,BC018164,Chromosome:20,20q13.1-q13.2 710,Tyrosine-protein phosphatase non-receptor type 6,2009-06-18 20:24:38 UTC,2009-06-30 03:51:41 UTC,P29350,"Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation","",">Tyrosine-protein phosphatase non-receptor type 6 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFA TLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLS QPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLR QPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNIL PFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMT TREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQM VRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHK EDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK",PTPN6,Protein-tyrosine phosphatase 1C; PTP-1C; Hematopoietic cell protein-tyrosine phosphatase; SH-PTP1; Protein-tyrosine phosphatase SHP-1,595,67562,7.88,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00017:SH2 PF00102:Y_phosphatase",HGNC:9658,Cytoplasm. Nucleus (By similarity),,"","",None,None,Non Essential,"",PTPN6,PTPN6,BC007667,Chromosome:12,12p13 711,Tyrosine-protein phosphatase non-receptor type 14,2009-06-18 20:25:50 UTC,2009-06-30 03:51:34 UTC,Q15678,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Tyrosine-protein phosphatase non-receptor type 14 MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKS QQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIR LAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVE RLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALF HTDDIENAKYISRLFATRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSE THTSQDSIFHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDI MRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQPEDLVYSQPEM RERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTPELANMQLQGSHNYSTAHMLK NYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTA TKHHGTVNKRHSLEVMNSMVRGMEAMTLKSLHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSD ATMLIHSSESEEEEEEAPESVPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQAS LPPAMARARVLRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSI IEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTLKKKLEEGMVF TEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYI ATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVC YATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVH CSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI",PTPN14,Protein-tyrosine phosphatase pez,1187,135263,8.44,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton","","PF00373:Band_41 PF00102:Y_phosphatase",HGNC:9647,"Cytoplasm, cytoskeleton (By similarity)",,"","",None,None,Non Essential,"",PTPN14,PTPN14,BC104803,"","" 712,Tyrosine-protein phosphatase non-receptor type 18,2009-06-18 20:26:13 UTC,2009-06-30 03:51:50 UTC,Q99952,Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues,"",">Tyrosine-protein phosphatase non-receptor type 18 MSRSLDSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYKDVLPYDQ TRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKR CERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAM VEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQ YRFLYHTVAQMFCSTLQNASPHYQNIKENCAPLYDDALFLRTPQALLAIPRPPGGVLRSISVPGSPGHAM ADTYAVVQKRGAPAGAGSGTQTGTGTGTGARSAEEAPLYSKVTPRAQRPGAHAEDARGTLPGRVPADQSP AGSGAYEDVAGGAQTGGLGFNLRIGRPKGPRDPPAEWTRV",PTPN18,Brain-derived phosphatase,460,50483,8.33,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9649,Nucleus (By similarity). Cytoplasm (By similarity),,"","",None,None,Non Essential,"",PTPN18,PTPN18,CH471263,"","" 713,Tyrosine-protein phosphatase non-receptor type 20,2009-06-18 20:26:41 UTC,2009-06-30 03:51:37 UTC,Q4JDL3,Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates,"",">Tyrosine-protein phosphatase non-receptor type 20 MSSPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSKVFENKVNSEKVKLSLRNFPHNDYEDVF EEPSESGSDPSMWTARGPFRRDRWSSEDEEAAGPSQALSPLLSDTRKIVSEGELDQLAQIRPLIFNFHEQ TAIKDCLKILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKDYIN ASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELK HFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMV VHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLLTLD",PTPN20A,hPTPN20a,420,48423,5.52,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:23422,Nucleus. Cytoplasm,,"","",None,None,Non Essential,"",PTPN20A,PTPN20A,BC113473,Chromosome:10,10q11.22 714,Tyrosine-protein phosphatase non-receptor type 23,2009-06-18 20:27:02 UTC,2009-06-30 03:51:37 UTC,Q9H3S7,May act as a negative regulator of Ras-mediated mitogenic activity,"",">Tyrosine-protein phosphatase non-receptor type 23 MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGCSVLRK YLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGM KVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQV VDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKL NEAIKLAKGQPDTVQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPA VTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQ LMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQAGAISITSKAE LAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALSPEDKAVLQNLKRIL AKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDRVLCAL TEANVQYAAVRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAR EAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLH FPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQ HGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCF PVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQH PHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLA YGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLL SSSPESQHGGTQSPGGGQPLLQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGA LDTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLV ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHV ERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGRTG AFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLA SASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPI PSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHN GQGLRATRPSDDPLSLLDPLWTLNKT",PTPN23,His domain-containing protein tyrosine phosphatase; HD-PTP; Protein tyrosine phosphatase TD14; PTP-TD14,1636,178975,6.91,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","","PF03097:BRO1 PF00102:Y_phosphatase",HGNC:14406,Cytoplasmic vesicle,,"","",None,None,Non Essential,"",PTPN23,PTPN23,AF169350,"","" 715,Tyrosine-protein phosphatase non-receptor type 2,2009-06-18 20:27:21 UTC,2009-06-30 03:51:39 UTC,P17706,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Tyrosine-protein phosphatase non-receptor type 2 MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYIN ASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETG FSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHG PAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIK GDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALR KRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWRLFFQQNAL",PTPN2,T-cell protein-tyrosine phosphatase; TCPTP,415,48529,8.61,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9650,Cytoplasm,,"","",None,None,Non Essential,1L8K,PTPN2,PTPN2,BC008244,Chromosome:18,18p11.3-p11.2 716,Tyrosine-protein phosphatase non-receptor type 3,2009-06-18 20:27:38 UTC,2009-06-30 03:51:40 UTC,P26045,May act at junctions between the membrane and the cytoskeleton,"",">Tyrosine-protein phosphatase non-receptor type 3 MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYF GLQHDDDSVDSPRWLEASKPIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLT CPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINI ARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESR EHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVW NPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGST EDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIV LINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTL EGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASY VNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGF HIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGIPDDSSDFLEFVNYVRSLRVDSEPVLV HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQML DPS",PTPN3,Protein-tyrosine phosphatase H1; PTP-H1,913,104031,7.04,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity Function: binding Function: protein binding Function: cytoskeletal protein binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: membrane Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton","","PF00373:Band_41 PF00595:PDZ PF00102:Y_phosphatase",HGNC:9655,Cell membrane,,"","",None,None,Non Essential,"",PTPN3,PTPN3,S76309,"","" 717,Tyrosine-protein phosphatase non-receptor type 5,2009-06-18 20:28:02 UTC,2009-06-30 03:51:50 UTC,P54829,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Tyrosine-protein phosphatase non-receptor type 5 MCCSERLLGRPQPIVMEALDEAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAAS QFLLACGVLWFSGYGHMWSQNATNLVSSLLTLLKQLEPTSWLDSGTWGVPGLLLVFLSVGLVLVTTLVWH LLRTPPEPPTPLPPEDRRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTV KSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQAEF FEIPMNFVVPKEYDIPGRCRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQG PIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKS GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQ QLRQEGVVDILKTTCQLRQDRGGMIQHCEQYQFVHHVMSLYEKQLSHQSPE",PTPN5,Protein-tyrosine phosphatase striatum-enriched; STEP; Neural-specific protein-tyrosine phosphatase,541,61092,4.77,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9657,Cytoplasmic,,"","",None,None,Non Essential,2BIJ,PTPN5,PTPN5,U27831,Chromosome:11,11p15.1 718,Receptor-type tyrosine-protein phosphatase N2,2009-06-18 20:28:25 UTC,2009-06-30 03:51:35 UTC,Q92932,Implicated in development of nervous system and pancreatic endocrine cells,"",">Receptor-type tyrosine-protein phosphatase N2 MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEGLCGASEACVNDGVFGRCQKVPAMDFY RYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYS REGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVAHTSALTYPPGSRT QLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLL APAAPQKWPSPLGDSEDPSSTGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARG SPGRAALGESGEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARP LDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAG AQEALSDGLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSA NVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIALTLVSLACILGVL LASGLIYCLRHSSQHRLKEKLSGLGGDPGADATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDG PIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREEN VPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCV VIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLS WYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEH LRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ",PTPRN2,R-PTP-N2; Islet cell autoantigen-related protein; ICAAR; IAR; Phogrin,1015,111273,5.63,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9677,Membrane,,"","",1-21,616-636,Non Essential,"",PTPRN2,PTPRN2,BC034040,"","" 719,Receptor-type tyrosine-protein phosphatase beta,2009-06-18 20:28:46 UTC,2009-06-30 03:51:42 UTC,P23467,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Receptor-type tyrosine-protein phosphatase beta MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPT FRIDNTTYGCNLQDLQAGTIYNFKIISLDEERTVVLQTDPLPPARFGVSKEKTTSTGLHVWWTPSSGKVT SYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIG ISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLSPGYLYNLTVMTEAAGLQNY RWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVP GRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTP VAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDL HVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI SSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLVAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFS SLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKN NFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAV KNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS GSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQH KFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLY NPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSL WFNWSPASGDFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTA PSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQF NVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFS RKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSIN FTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSN SKSFNIKLGAEMESLGGKRDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPIT TESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTS CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVD DDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQ DSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDY INRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV RDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH",PTPRB,Protein-tyrosine phosphatase beta; R-PTP-beta,1997,224270,7.72,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","","PF00041:fn3 PF00102:Y_phosphatase",HGNC:9665,Membrane,,"","",1-22,1622-1642,Non Essential,"",PTPRB,PTPRB,X54131,Chromosome:12,12q15-q21 720,Receptor-type tyrosine-protein phosphatase delta,2009-06-18 20:29:02 UTC,2009-06-30 03:51:43 UTC,P23468,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Receptor-type tyrosine-protein phosphatase delta MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFE VIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERT RTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVAT NSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPED DMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEP VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSV KVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQ RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSW QPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESL SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVML ADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKE ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMT LTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPF KILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL DGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKP YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPG MASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLS AIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP SRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMG REKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGF IDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTE DQYQFSYRAALEYLGSFDHYAT",PTPRD,Protein-tyrosine phosphatase delta; R-PTP-delta,1912,214762,6.54,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","","PF00041:fn3 PF07679:I-set PF00047:ig PF00102:Y_phosphatase",HGNC:9668,Membrane,,"","",1-20,1266-1290,Non Essential,1LAR,PTPRD,PTPRD,X54133,"","" 721,Receptor-type tyrosine-protein phosphatase epsilon,2009-06-18 20:29:23 UTC,2009-06-30 03:51:40 UTC,P23469,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Receptor-type tyrosine-protein phosphatase epsilon MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLLVLLLAAYFFR FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFN SLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGP KQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ PQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDA MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTH FDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGY RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTL SEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHC SAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK",PTPRE,Protein-tyrosine phosphatase epsilon; R-PTP-epsilon,700,80643,7.02,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9669,Isoform 2:Cytoplasm,,"","",1-19,47-69,Non Essential,"",PTPRE,PTPRE,BC050062,Chromosome:10,10q26 722,Receptor-type tyrosine-protein phosphatase F,2009-06-18 20:29:55 UTC,2009-06-30 03:51:47 UTC,P10586,"The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one","",">Receptor-type tyrosine-protein phosphatase F MVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKAR TATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAP ANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNV VRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTM LVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPS PTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLE DLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVIT QYSVAHEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSG PPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGEL LGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQ NLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRA WTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSM RKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR WFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLA VILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADN IERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANY IDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLL DTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSA GVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVE GSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSAR YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFG QDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG SFDHYAT",PTPRF,LAR protein; Leukocyte antigen related,1897,211847,6.26,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","","PF00041:fn3 PF07679:I-set PF00102:Y_phosphatase",HGNC:9670,Membrane,,"","",1-16,1251-1274,Non Essential,1LAR,PTPRF,PTPRF,Y00815,"","" 723,Receptor-type tyrosine-protein phosphatase gamma,2009-06-18 20:30:14 UTC,2009-06-30 03:51:34 UTC,P23470,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Receptor-type tyrosine-protein phosphatase gamma MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSGAYGPEH WVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLP GRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRD NSALDPIIHGLKGVVHHEKETFLDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQ LEAFYSIFTTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSSPP IHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYL FRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFV SMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPTAASASKQAARPVLATTEALA SPGPDGDSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPSPTPSSP NRTAEGGHQTIPGHEQDHTAVPTDQTGGRRDAGPGLDPDMVTSTQVPPTATEEQYAGSDPKRPEMPSKKP MSRGDRFSEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKS KGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGEL YSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINAN YVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTL KSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARM PETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI LGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERA RVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF VYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTF ELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQY QFIYKARLSLVSTKENGNGPMTVDKNGAVLIADESDPAESMESLV",PTPRG,Protein-tyrosine phosphatase gamma; R-PTP-gamma,1445,162030,6.42,">>> Function: protein tyrosine phosphatase activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,"PF00194:Carb_anhydrase PF00041:fn3 PF00102:Y_phosphatase",HGNC:9671,Membrane,,"","",1-19,737-762,Non Essential,"",PTPRG,PTPRG,X54132,"","" 724,Receptor-type tyrosine-protein phosphatase H,2009-06-18 20:30:36 UTC,2009-06-30 03:51:47 UTC,Q9HD43,"May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion- associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms:inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP-70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells","",">Receptor-type tyrosine-protein phosphatase H MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGD GGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWE VPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNP VRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVE KDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTN ITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYW VEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNST IALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLT AATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWY KVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEV GGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVG LLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVAS ASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQ QSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFH YQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFS FVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV",PTPRH,Transmembrane-type protein-tyrosine phosphatase type H; Stomach cancer-associated protein tyrosine phosphatase 1; SAP-1,1115,122354,4.94,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","","PF00041:fn3 PF00102:Y_phosphatase",HGNC:9672,Membrane,,"","",1-27,755-775,Non Essential,"",PTPRH,PTPRH,BC111716,Chromosome:19,19q13.4 725,Receptor-type tyrosine-protein phosphatase eta,2009-06-18 20:30:51 UTC,2009-06-30 03:51:48 UTC,Q12913,May contribute to the mechanism of contact inhibition of cell growth,"",">Receptor-type tyrosine-protein phosphatase eta MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQISSTAESFHK QNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWK SNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPV SDLRVALTGVRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKT KGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAA NGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEG AGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDW KSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVS NIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQ VGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSS ENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF EASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGN ESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGC IFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKL VGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTL KDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTS ESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLAPVTTFG KTNGYIA",PTPRJ,Protein-tyrosine phosphatase eta; R-PTP-eta; HPTP eta; Protein-tyrosine phosphatase receptor type J; Density-enhanced phosphatase 1; DEP-1; CD148 antigen,1337,145942,5.28,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","","PF00041:fn3 PF00102:Y_phosphatase",HGNC:9673,Membrane,,"","",1-35,976-996,Non Essential,"",PTPRJ,PTPRJ,AF387844,Chromosome:11,11p11.2 726,Receptor-type tyrosine-protein phosphatase kappa,2009-06-18 20:31:17 UTC,2009-06-30 03:51:40 UTC,Q15262,"Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTP- kappa","",">Receptor-type tyrosine-protein phosphatase kappa MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPP EMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWN VTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQ NATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGV SNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKL WHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMH LHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAY QIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPP LAPRKGYNIYFQAMSSVEKETKTQCVRIATKAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVV ILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAES SRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQN RAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSAC IVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPD HGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAE DCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWR LVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMV QQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQN VVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS",PTPRK,Protein-tyrosine phosphatase kappa; R-PTP-kappa,1439,162104,5.75,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: cell Component: membrane","","PF00041:fn3 PF00047:ig PF00629:MAM PF00102:Y_phosphatase",HGNC:9674,"Cell junction, adherens junction. Cell membrane",,"","",1-26,753-774,Non Essential,"",PTPRK,PTPRK,AL590006,"","" 727,Receptor-type tyrosine-protein phosphatase mu,2009-06-18 20:31:42 UTC,2009-06-30 03:51:45 UTC,P28827,Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control,"",">Receptor-type tyrosine-protein phosphatase mu MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFML VNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTW NRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIG RTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKE PPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYE ISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESI QGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYS FTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERP RRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRI YFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLA KKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEG QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIY DFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEI REIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV VDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEF RTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRI YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFC AISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG",PTPRM,Protein-tyrosine phosphatase mu; R-PTP-mu,1452,163684,6.64,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: cell Component: membrane","","PF00041:fn3 PF00047:ig PF00629:MAM PF00102:Y_phosphatase",HGNC:9675,Membrane,,"","",1-20,743-764,Non Essential,1RPM,PTPRM,PTPRM,X58288,Chromosome:18,18p11.2 728,Receptor-type tyrosine-protein phosphatase-like N,2009-06-18 20:31:58 UTC,2009-06-30 03:51:47 UTC,Q16849,"Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2","",">Receptor-type tyrosine-protein phosphatase-like N MRRPRRPGGLGGSGGLRLLLCLLLLSSRPGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFGQCQVGVGQAR PLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPEPRPRDRSGLAPKRPGPAGEL LLQDIPTGSAPAAQHRLPQPPVGKGGAGASSSLSPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQPYL FHQFGSRDGSRVSEGSPGMVSVGPLPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLY LAQELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGDRGEKPASPAVQPDAALQRLAAVLAGYGVELR QLTPEQLSTLLTLLQLLPKGAGRNPGGVVNVGADIKKTMEGPVEGRDTAELPARTSPMPGHPTASPTSSE VQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAEEYGYIVTDQKPLSLAAGVKLL EILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEA AAVLPQTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCVRQHARQQDKERLAALGPEGAHGDTTFEYQD LCRQHMATKSLFNRAEGPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYME DHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPI IEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLV SEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCS DGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKALPQ",PTPRN,R-PTP-N; PTP IA-2; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3,979,105849,7.12,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9676,Membrane,,"","",1-34,576-600,Non Essential,"",PTPRN,PTPRN,X62899,"","" 729,Receptor-type tyrosine-protein phosphatase O,2009-06-18 20:32:18 UTC,2009-06-30 03:51:45 UTC,Q16827,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Receptor-type tyrosine-protein phosphatase O MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKITGESKNYFFE FEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFE IHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNHWLPGMCYSNITFQLVSEATFNKSTLVEYSG VSHEPKQHRTAPYPPQNISVRIVNLNKNNWEEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNIS SGWPDFNSSDYETTSQPYWWDSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWL PPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVN SSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRK YVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFIT APVAPEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYN LSVTACTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEP VAVSSHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT LIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLK KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVR LVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHY WPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHM VRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ CVQLMWMKKKQQFCISDVIYENVSKS",PTPRO,Glomerular epithelial protein 1; Protein tyrosine phosphatase U2; PTPase U2; PTP-U2,1216,138345,5.89,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","","PF00041:fn3 PF00102:Y_phosphatase",HGNC:9678,Membrane,,"","",1-29,823-843,Non Essential,"",PTPRO,PTPRO,BC126203,Chromosome:12,12p13.3-p13.2|12p13-p12 730,Receptor-type tyrosine-protein phosphatase R,2009-06-18 20:32:35 UTC,2009-06-30 03:51:49 UTC,Q15256,"Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity)","",">Receptor-type tyrosine-protein phosphatase R MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQKIYRHSYHSSS EAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGV AAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEK NVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPAL SEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSL GNIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNR YKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVM ITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDS AQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGM VQTSEQYEFVHHALCLYESRLSAETVQ",PTPRR,Protein-tyrosine phosphatase PCPTP1; NC-PTPCOM1; Ch-1PTPase,657,73835,8.46,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9680,"Isoform Gamma:Cytoplasm, perinuclear region",,"","",1-21,228-248,Non Essential,1JLN,PTPRR,PTPRR,X82635,Chromosome:12,12q15 731,Receptor-type tyrosine-protein phosphatase S,2009-06-18 20:32:51 UTC,2009-06-30 03:51:41 UTC,Q13332,Interacts with LAR-interacting protein LIP.1,"",">Receptor-type tyrosine-protein phosphatase S MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKG KKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMG PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEETD QGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQ GAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI TWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLF REGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSV RSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHT EVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARG PPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSR GGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSV LLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFN LLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISR LQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADL APHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRRQNAYIATQGPLPE TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIK PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAY IATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT",PTPRS,R-PTP-S; Receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma,1948,217097,6.46,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","","PF00041:fn3 PF07679:I-set PF00047:ig PF00102:Y_phosphatase",HGNC:9681,Membrane,,"","",1-29,1283-1303,Non Essential,"",PTPRS,PTPRS,S78080,Chromosome:19,19p13.3 732,Receptor-type tyrosine-protein phosphatase T,2009-06-18 20:33:08 UTC,2009-06-30 03:51:40 UTC,O14522,May be involved in both signal transduction and cellular adhesion in the CNS,"",">Receptor-type tyrosine-protein phosphatase T MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVP TGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSG VVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNAT FQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNY AELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHL DPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPL ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGT TYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKE ERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKS YSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVI AGLLMFIIILLGVMLTIKRRRNAYSYSYYLSQRKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDE GFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYG FKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYI ATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRT FTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAID TMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP QTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMD SHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADI DEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHC LNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF",PTPRT,R-PTP-T; RPTP-rho,1463,164347,6.93,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: cell Component: membrane","","PF00041:fn3 PF00629:MAM PF00102:Y_phosphatase",HGNC:9682,Membrane,,"","",1-25,767-787,Non Essential,"",PTPRT,PTPRT,Z93942,Chromosome:20,20q12-q13 733,Receptor-type tyrosine-protein phosphatase zeta,2009-06-18 20:33:24 UTC,2009-06-30 03:51:42 UTC,P23471,May be involved in the regulation of specific developmental processes in the CNS,"",">Receptor-type tyrosine-protein phosphatase zeta MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDL TQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGS EHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQA ALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDY LQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLY QQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPE LIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFS GKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESL NTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESARNA SEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMS QGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPL VTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQ ILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEP PSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLITPT ASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGN ETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQVPE NNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASD VDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGL TISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKL IHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAVSPHRDGSVTSTKLLFPSKATS ELSHSAKSDAGLVGGGEDGDTDDDGDDDDDRDSDGLSIHKCMSCSSYRESQEKVMNDSDTHENSLMDQNN PISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWA VLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHV SEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPRV ISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNK HKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVE VIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVV TQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNI FGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLS QSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLH TIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFI LEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMH QLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALPDGNIAESL ESLV",PTPRZ1,R-PTP-zeta; R-PTP-zeta-2; Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2,2314,254532,4.50,">>> Function: protein tyrosine phosphatase activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,"PF00194:Carb_anhydrase PF00041:fn3 PF00102:Y_phosphatase",HGNC:9685,Membrane,,"","",1-24,1636-1661,Non Essential,"",PTPRZ1,PTPRZ1,X54135,"","" 734,Tyrosine-protein phosphatase non-receptor type 22,2009-06-18 20:33:52 UTC,2009-06-30 03:51:35 UTC,Q9Y2R2,Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases,"",">Tyrosine-protein phosphatase non-receptor type 22 MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSR VELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCE RYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIW DVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYE LVYNAVLELFKRQMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKE SSSFDFRTSEISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSCFVEMQAQKVM HVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGT VFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQESAVLATAPRIDDEIPPPLPVRTPESFIVVEE AGEFSPNVPKSLSSAVKVKIGTSLEWGGTSEPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPER TLESFFLADEDCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNK PAESVQSNNSSSFLNFGFANRFSKPKGPRNPPPTWNI",PTPN22,Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP,807,91705,7.65,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available","",PF00102:Y_phosphatase,HGNC:9652,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",PTPN22,PTPN22,AF077031,"","" 735,Tyrosine-protein phosphatase non-receptor type 4,2009-06-18 20:35:01 UTC,2009-06-30 03:51:45 UTC,P29074,May act at junctions between the membrane and the cytoskeleton,"",">Tyrosine-protein phosphatase non-receptor type 4 MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYF GLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLP CPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNT ARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESR ETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKAN KDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLV DHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESH INETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRL NEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLD SVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG NEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEP TGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK VYEEGFVKPLTTSTNK",PTPN4,Protein-tyrosine phosphatase MEG1; PTPase-MEG1; MEG,926,105912,7.47,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity Function: binding Function: protein binding Function: cytoskeletal protein binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: membrane Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton","","PF00373:Band_41 PF08736:FA PF00595:PDZ PF00102:Y_phosphatase",HGNC:9656,Cell membrane,,"","",None,None,Non Essential,"",PTPN4,PTPN4,BC010674,"","" 736,Tyrosine-protein phosphatase non-receptor type 9,2009-06-18 20:35:19 UTC,2009-06-30 03:51:36 UTC,P43378,Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus,"",">Tyrosine-protein phosphatase non-receptor type 9 MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRE TRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVD SFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKV RERIQILKTSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHV PGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRS GHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQ QSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQT PEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ",PTPN9,Protein-tyrosine phosphatase MEG2; PTPase-MEG2,593,68021,8.10,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity Function: transporter activity || >>> Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: intracellular","","PF00650:CRAL_TRIO PF03765:CRAL_TRIO_N PF00102:Y_phosphatase",HGNC:9661,Cytoplasm (Probable),,"","",None,None,Non Essential,"",PTPN9,PTPN9,BC010863,Chromosome:15,15q24.2 737,Tyrosine-protein phosphatase non-receptor type 21,2009-06-18 20:35:44 UTC,2009-06-30 03:51:46 UTC,Q16825,Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate,"",">Tyrosine-protein phosphatase non-receptor type 21 MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYN KQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQA IQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQE VERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETI QFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGH YTEPYASSQDNLFVPNQNGYYCHSQTSLDRAQIDFNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPS ITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSSYAYSRPAALV YSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVPELTNAQLQAQDYPSPNIMRT QVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARHA QLHKRNSIEVAGLSHGLEGLRLKERTLSASAAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKS LSDATMLIHSSEEEEDEDFEEESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKR MMDSSPVRTTAEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMK KTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEYERILKKRLVD GECSTARLPENAERNRFQDVLPYDDARVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQD FWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLL TGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVIL SEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI",PTPN21,Protein-tyrosine phosphatase D1,1174,133289,7.96,">>> Function: protein tyrosine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton","","PF00373:Band_41 PF00102:Y_phosphatase",HGNC:9651,"Cytoplasm, cytoskeleton (By similarity)",,"","",None,None,Non Essential,"",PTPN21,PTPN21,X79510,Chromosome:14,14q31.3 738,Protein-tyrosine phosphatase mitochondrial 1,2009-06-18 20:36:18 UTC,2009-06-30 03:51:34 UTC,Q8WUK0,"Protein phosphatase that specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity)","",">Protein-tyrosine phosphatase mitochondrial 1 MAATALLEAGLARVLFYPTLLYTLFRGKVPGRAHRDWYHRIDPTVLLGALPLRSLTRQLVQDENVRGVIT MNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSA TMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITARATKDGTFVISKT",PTPMT1,PTEN-like phosphatase; Phosphoinositide lipid phosphatase,201,22844,10.24,">>> Function: protein tyrosine/serine/threonine phosphatase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: phosphoprotein phosphatase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid dephosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF00782:DSPc,HGNC:26965,Mitochondrion inner membrane (By similarity),,"","",None,None,Non Essential,"",PTPMT1,PTPMT1,BC020242,Chromosome:11,11p11.2 739,Neuronal acetylcholine receptor subunit alpha-3,2009-06-18 20:50:04 UTC,2009-06-30 03:51:49 UTC,P32297,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Neuronal acetylcholine receptor subunit alpha-3 MALAVSLPLALSPPRLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLV KVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLK YTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKA PGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLS LTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPR VMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRS SSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTA GLFLQPLMAREDA",CHRNA3,"",503,57311,6.40,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1957,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-29,"239-263 271-289 305-326 476-495",Non Essential,"",CHRNA3,CHRNA3,X53559,Chromosome:15,15q24 740,Neuronal acetylcholine receptor subunit alpha-6,2009-06-18 21:32:55 UTC,2009-06-30 03:51:46 UTC,Q15825,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Neuronal acetylcholine receptor subunit alpha-6 MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQL ANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALL KYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIID ASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLL SLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLP QVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVV ENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLLGN TGKS",CHRNA6,"",494,56899,6.60,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:15963,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-25,"240-264 272-290 306-327 466-484",Non Essential,"",CHRNA6,CHRNA6,BC014456,"","" 741,Neuronal acetylcholine receptor subunit beta-3,2009-06-18 21:34:45 UTC,2009-06-30 03:51:41 UTC,Q05901,"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane","",">Neuronal acetylcholine receptor subunit beta-3 MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDE KNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGT VVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMK GNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLL VIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMK DHVDRYSSPEKEESQPVVKGKVLEKKKQKQLSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWK FVAQVLDRIFLWLFLIVSVTGSVLIFTPALKMWLHSYH",CHRNB3,"",458,52729,8.29,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:1963,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-24,"233-257 265-282 299-320 429-447",Non Essential,"",CHRNB3,CHRNB3,X67513,"","" 742,Neuronal acetylcholine receptor subunit alpha-10,2009-06-18 21:39:41 UTC,2009-06-30 03:51:43 UTC,Q9GZZ6,"Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma","",">Neuronal acetylcholine receptor subunit alpha-10 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMD ERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDG AVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPAR RRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTV FQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCV RERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK RLARVMDRFFLAIFFSMALVMSLLVLVQAL",CHRNA10,Nicotinic acetylcholine receptor subunit alpha 10; NACHR alpha 10,450,49705,7.97,">>> Function: excitatory extracellular ligand-gated ion channel activity Function: nicotinic acetylcholine-activated cation-selective channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:13800,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-24,"238-258 268-288 302-322 429-449",Non Essential,"",CHRNA10,CHRNA10,AJ295237,Chromosome:11,11p15.5 743,Multidrug resistance protein 1,2009-06-24 20:56:31 UTC,2009-08-13 06:39:46 UTC,P08183,Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells,"",">Multidrug resistance protein 1 MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMML VFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAA GRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTR GWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKN LEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRY GRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSA LDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQT AGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRI MKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITF FLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSL TQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSA VVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDI PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEP ILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARAL VRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL LAQKGIYFSMVSVQAGTKRQ",ABCB1,ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243 antigen,1280,141464,9.44,">>> Function: ATPase activity Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: ATPase activity, coupled to transmembrane movement of substances Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: binding Function: nucleotide binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Defense mechanisms,"PF00664:ABC_membrane PF00005:ABC_tran",HGNC:40,Membrane,,"","",None,"52-72 120-140 189-209 216-236 297-317 326-346 711-731 757-777 833-853 854-874 937-957 974-994",Non Essential,"",ABCB1,ABCB1,X58723,"","" 744,Liver carboxylesterase 1,2009-06-25 20:23:03 UTC,2009-08-13 06:39:30 UTC,P23141,"Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester","",">Liver carboxylesterase 1 MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQP AEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIH GGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGG NPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSA VMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGI NKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEI RLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKEVAFWTNLFAKKAVEKPP QTEHIEL",CES1,Acyl coenzyme A:cholesterol acyltransferase; ACAT; Monocyte/macrophage serine esterase; HMSE; Serine esterase 1; Brain carboxylesterase hBr1; Triacylglycerol hydrolase; TGH; Egasyn; Retinyl ester hydrolase; REH,567,62522,6.58,"",Lipid transport and metabolism,PF00135:COesterase,HGNC:1863,Endoplasmic reticulum lumen,,"","",1-18,None,Non Essential,1MX1,CES1,CES1,M65261,"","" 745,Carboxylesterase 2,2009-06-25 20:25:57 UTC,2009-08-13 06:39:52 UTC,O00748,"Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine","",">Carboxylesterase 2 MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGP LRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNL PVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQ NIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSAC DQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLI PKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPA LQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKY WANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL",CES2,CE-2; hCE-2,559,61808,6.03,"",Lipid transport and metabolism,PF00135:COesterase,HGNC:1864,Endoplasmic reticulum lumen (By similarity),,"","",1-26,None,Non Essential,"",CES2,CES2,U60553,"","" 746,Glutathione S-transferase theta-2,2009-06-26 17:08:24 UTC,2009-08-13 06:39:43 UTC,P30712,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity,"",">Glutathione S-transferase theta-2 MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDGDFILTESSAI LIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLGPLIGVQVPEEKVERNRTAMD QALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALGYELFEGRPRLAAWRGRVEAFLGAELCQEAH SIILSILEQAAKKTLPTPSPEAYQAMLLRIARIP",GSTT2,GST class-theta-2,244,27507,6.36,"","Posttranslational modification, protein turnover, chaperones","PF00043:GST_C PF02798:GST_N",HGNC:4642,Cytoplasm,,"","",None,None,Non Essential,3LJR,GSTT2,GSTT2,BC002415,"","" 747,Glutathione S-transferase Mu 1,2009-06-26 17:08:46 UTC,2009-08-13 06:39:44 UTC,P09488,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles,"",">Glutathione S-transferase Mu 1 MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKI TQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEFEKLKPKYLEELPEKLKLYSE FLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFS KMAVWGNK",GSTM1,GSTM1-1; GST class-mu 1; GSTM1a-1a; GSTM1b-1b; HB subunit 4; GTH4,218,25712,6.67,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:4632,Cytoplasm,,"","",None,None,Non Essential,1XWK,GSTM1,GSTM1,X51451,"","" 748,Glutathione S-transferase A4,2009-06-26 17:09:05 UTC,2009-08-13 06:39:35 UTC,O15217,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE),"",">Glutathione S-transferase A4 MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEIDGMKLVQTRS ILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVVNMAQKAIIRYFPVFEKIL RGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPFLQEYTVKLSNIPTIKRFLEPGSKKKPPPDE IYVRTVYNIFRP",GSTA4,Glutathione S-transferase A4-4; GST class-alpha member 4,222,25705,8.72,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:4629,Cytoplasm,,"","",None,None,Non Essential,1GUM,GSTA4,GSTA4,BC015523,"","" 749,Glutathione S-transferase Mu 4,2009-06-26 17:09:20 UTC,2009-08-13 06:39:45 UTC,Q03013,"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1- chloro-2,4-dinitrobenzene","",">Glutathione S-transferase Mu 4 MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKI TQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDFEKLKPEYLEELPTMMQHFSQ FLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPNCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPKPLYT RVAVWGNK",GSTM4,GSTM4-4; GST class-mu 4; GTS-Mu2,218,25562,5.69,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:4636,Cytoplasm,,"","",None,None,Non Essential,4GTU,GSTM4,GSTM4,BC108729,"","" 750,Glutathione S-transferase A1,2009-06-26 17:09:35 UTC,2009-08-13 06:39:51 UTC,P08263,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles,"",">Glutathione S-transferase A1 MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRA ILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVL KSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDE KSLEEARKIFRF",GSTA1,GTH1; HA subunit 1; GST-epsilon; GSTA1-1; GST class-alpha member 1,222,25631,9.34,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:4626,Cytoplasm,,"","",None,None,Non Essential,1K3Y,GSTA1,GSTA1,BC053578,"","" 751,Glutathione S-transferase A3,2009-06-26 17:09:51 UTC,2009-08-13 06:39:34 UTC,Q16772,"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively","",">Glutathione S-transferase A3 MAGKPKLHYFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGKLRNDGSLMFQQVPMVEIDGMKLVQTRA ILNYIASKYNLYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAKIALIKEKTKSRYFPAFEKVL QSHGQDYLVGNKLSRADISLVELLYYVEELDSSLISNFPLLKALKTRISNLPTVKKFLQPGSPRKPPADA KALEEARKIFRF",GSTA3,Glutathione S-transferase A3-3; GST class-alpha member 3,222,25302,9.69,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:4628,Cytoplasm,,"","",None,None,Non Essential,1TDI,GSTA3,GSTA3,BC020619,"","" 752,Glutathione S-transferase A2,2009-06-26 17:10:03 UTC,2009-08-13 06:39:37 UTC,P09210,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles,"",">Glutathione S-transferase A2 MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRA ILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAKLALIQEKTKNRYFPAFEKVL KSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDE KSLEESRKIFRF",GSTA2,GTH2; HA subunit 2; GST-gamma; GSTA2-2; GST class-alpha member 2,222,25664,9.07,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:4627,Cytoplasm,,"","",None,None,Non Essential,1AGS,GSTA2,GSTA2,BC002895,"","" 753,Glutathione S-transferase omega-1,2009-06-26 17:10:15 UTC,2009-08-13 06:40:00 UTC,P78417,Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities,"",">Glutathione S-transferase omega-1 MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFG LVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYA GLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPWFERLEAMKLNECVDHTPKLKLWMAAMKEDP TVSALLTSEKDWQGFLELYLQNSPEACDYGL",GSTO1,GSTO 1-1,241,27566,6.54,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: cell Component: intracellular Component: cytoplasm","Posttranslational modification, protein turnover, chaperones","PF00043:GST_C PF02798:GST_N",HGNC:13312,Cytoplasm,,"","",None,None,Non Essential,1EEM,GSTO1,GSTO1,BC000127,"","" 754,Glutathione S-transferase kappa 1,2009-06-26 17:10:26 UTC,2009-08-13 06:39:57 UTC,Q9Y2Q3,"Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB)","",">Glutathione S-transferase kappa 1 MGPLPRTVELFYDVLSPYSWLGFEILCRYQNIWNINLQLRPSLITGIMKDSGNKPPGLLPRKGLYMANDL KLLRHHLQIPIHFPKDFLSVMLEKGSLSAMRFLTAVNLEHPEMLEKASRELWMRVWSRNEDITEPQSILA AAEKAGMSAEQAQGLLEKIATPKVKNQLKETTEAACRYGAFGLPITVAHVDGQTHMLFGSDRMELLAHLL GEKWMGPIPPAVNARL",GSTK1,Glutathione S-transferase subunit 13; GST 13-13; GST class-kappa; GSTK1-1; hGSTK1,226,25497,8.69,">>> Function: catalytic activity Function: oxidoreductase activity Function: disulfide oxidoreductase activity Function: protein disulfide oxidoreductase activity || >>> Process: Not Available || >>> Component: cell Component: periplasmic space Component: periplasmic space (sensu Gram-negative Bacteria)","",PF01323:DSBA,HGNC:16906,Peroxisome,,"","",None,None,Non Essential,"",GSTK1,GSTK1,BC050715,"","" 755,Glutathione S-transferase Mu 3,2009-06-26 17:10:37 UTC,2009-08-13 06:39:37 UTC,P21266,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers,"",">Glutathione S-transferase Mu 3 MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLDFPNLPYLLDG KNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCYSSDHEKLKPQYLEELPGQLK QFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLDEFPNLKAFMCRFEALEKIAAYLQSDQFCKM PINNKMAQWGNKPVC",GSTM3,GSTM3-3; GST class-mu 3; hGSTM3-3,225,26560,5.19,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:4635,Cytoplasm,,"","",None,None,Non Essential,3GTU,GSTM3,GSTM3,BC008790,"","" 756,Glutathione S-transferase Mu 2,2009-06-26 17:10:50 UTC,2009-08-13 06:39:56 UTC,P28161,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles,"",">Glutathione S-transferase Mu 2 MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKI TQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDFEKLKPEYLQALPEMLKLYSQ FLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFT KMAVWGNK",GSTM2,GSTM2-2; GST class-mu 2,218,25745,6.29,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:4634,Cytoplasm,,"","",None,None,Non Essential,1XW5,GSTM2,GSTM2,BC105066,"","" 757,Glutathione S-transferase omega-2,2009-06-26 17:11:01 UTC,2009-08-13 06:39:48 UTC,Q9H4Y5,RX + glutathione = HX + R-S-glutathione,"",">Glutathione S-transferase omega-2 MSGDATRTLGKGSQPPGPVPEGLIRIYSMRFCPYSHRTRLVLKAKDIRHEVVNINLRNKPEWYYTKHPFG HIPVLETSQCQLIYESVIACEYLDDAYPGRKLFPYDPYERARQKMLLELFCKVPHLTKECLVALRCGREC TNLKAALRQEFSNLEEILEYQNTTFFGGTCISMIDYLLWPWFERLDVYGILDCVSHTPALRLWISAMKWD PTVCALLMDKSIFQGFLNLYFQNNPNAFDFGLC",GSTO2,GSTO-2,243,28254,7.62,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: cell Component: intracellular Component: cytoplasm","Posttranslational modification, protein turnover, chaperones",PF02798:GST_N,HGNC:23064,"",,"","",None,None,Non Essential,"",GSTO2,GSTO2,AY191318,"","" 758,Microsomal glutathione S-transferase 1 ,2009-06-26 17:11:16 UTC,2009-08-13 06:39:31 UTC,P10620,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity,"",">Microsomal glutathione S-transferase 1 MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVE RVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIAYLTPLPQPNRALSFFVGYGV TLSMAYRLLKSKLYL",MGST1,Microsomal GST-1; Microsomal GST-I,155,17599,9.71,"","",PF01124:MAPEG,HGNC:7061,Microsome (By similarity). Mitochondrion outer membrane,,"","",None,None,Non Essential,"",MGST1,MGST1,BC005923,"","" 759,Glutathione S-transferase A5,2009-06-26 17:11:30 UTC,2009-08-13 06:39:32 UTC,Q7RTV2,RX + glutathione = HX + R-S-glutathione,"",">Glutathione S-transferase A5 MAEKPKLHYSNARGSMESIRWLLAAAGVELEEKFLESAEDLDKLRNDGSLLFQQVPMVEIDGMKLVQTRA ILNYIASKYNLYGKDMKERALIDMYTEGIVDLTEMILLLLICQPEERDAKTALVKEKIKNRYFPAFEKVL KSHRQDYLVGNKLSWADIHLVELFYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSQRKPPMDE KSLEEARKIFRF",GSTA5,Glutathione S-transferase A5-5; GST class-alpha member 5,222,25722,8.37,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:19662,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",GSTA5,GSTA5,BK000212,"","" 760,Microsomal glutathione S-transferase 2,2009-06-26 17:11:41 UTC,2009-08-13 06:39:51 UTC,Q99735,"Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione","",">Microsomal glutathione S-transferase 2 MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMA GWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIA KKLRRQF",MGST2,Microsomal GST-2; Microsomal GST-II,147,16621,9.88,">>> Function: enzyme regulator activity Function: enzyme activator activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: organic acid metabolism Process: carboxylic acid metabolism Process: fatty acid metabolism Process: icosanoid metabolism Process: leukotriene metabolism || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF01124:MAPEG,HGNC:7063,Endoplasmic reticulum membrane,,"","",None,"6-26 59-79 111-131",Non Essential,"",MGST2,MGST2,BC025416,"","" 761,Maleylacetoacetate isomerase,2009-06-26 17:12:12 UTC,2009-08-13 06:39:50 UTC,O43708,"Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid","",">Maleylacetoacetate isomerase MQAGKPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDRGQQFSKDFQALNPMKQVPTLKIDGITIH QSLAIIEYLEETRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFN ALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDT PTELRA",GSTZ1,MAAI; Glutathione S-transferase zeta 1; GSTZ1-1,216,24182,8.71,">>> Function: catalytic activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: aromatic amino acid family metabolism || >>> Component: cell Component: intracellular Component: cytoplasm","Posttranslational modification, protein turnover, chaperones","PF00043:GST_C PF02798:GST_N",HGNC:4643,Cytoplasm (By similarity),,"","",None,None,Non Essential,1FW1,GSTZ1,GSTZ1,BC001453,"","" 762,Microsomal glutathione S-transferase 3 ,2009-06-26 17:12:23 UTC,2009-08-13 06:40:00 UTC,O14880,Also functions as a glutathione peroxidase,"",">Microsomal glutathione S-transferase 3 MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTLEVYPP FLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSIALLGLVGTTVCSAFQHLGWV KSGLGSGPKCCH",MGST3,Microsomal GST-3; Microsomal GST-III,152,16516,9.68,"","",PF01124:MAPEG,HGNC:7064,Endoplasmic reticulum membrane,,"","",None,"9-29 71-91 120-140",Non Essential,"",MGST3,MGST3,BC005964,"","" 763,Glutathione S-transferase Mu 5,2009-06-26 17:12:35 UTC,2009-08-13 06:39:37 UTC,P46439,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles,"",">Glutathione S-transferase Mu 5 MPMTLGYWDIRGLAHAIRLLLEYTDSSYVEKKYTLGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKI TQSNAILRYIARKHNLCGETEEEKIRVDILENQVMDNHMELVRLCYDPDFEKLKPKYLEELPEKLKLYSE FLGKRPWFAGDKITFVDFLAYDVLDMKRIFEPKCLDAFLNLKDFISRFEGLKKISAYMKSSQFLRGLLFG KSATWNSK",GSTM5,GSTM5-5; GST class-mu 5,218,25675,7.49,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: glutathione transferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00043:GST_C PF02798:GST_N",HGNC:4637,Cytoplasm,,"","",None,None,Non Essential,"",GSTM5,GSTM5,BC058881,"","" 764,Glutathione S-transferase theta-4,2009-06-26 17:12:47 UTC,2009-08-13 06:39:29 UTC,A8MPT4,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity),"",">Glutathione S-transferase theta-4 MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGHHHSKEYIDINPLRKLPSLKDGKFILSESAAI LYYLCRKYSAPSHWCPPDLHARARVDEFVAWQHTAFQLPMKKIVWLKLLIPKITGEEVSAEKMEHAVEEV KNSLQLFEEYFLQDKMFITGNQISLADLVAVVEMMQPMAANYNVFLNSSKLAEWRMQVELNIGSGLFREA HDRLMQLADWDFSTLDSMVKENISELLKKSR",GSTT4,GST class-theta-4,241,27960,6.72,"","Posttranslational modification, protein turnover, chaperones","PF00043:GST_C PF02798:GST_N","",Cytoplasm (By similarity),,"","",None,None,Non Essential,"",GSTT4,"","","","" 765,"Fatty acid-binding protein, brain",2009-06-29 16:57:27 UTC,2009-08-13 06:39:59 UTC,O15540,"B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity)","",">Fatty acid-binding protein, brain MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKVVIRTLSTFKNTEISFQLGEE FDETTADDRNCKSVVSLDGDKLVHIQKWDGKETNFVREIKDGKMVMTLTFGDVVAVRHYEKA",FABP7,B-FABP; Fatty acid-binding protein 7; Brain lipid-binding protein; BLBP; Mammary-derived growth inhibitor related,132,14889,5.25,">>> Function: lipid binding Function: binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available","",PF00061:Lipocalin,HGNC:3562,Cytoplasm,,"","",None,None,Non Essential,1FE3,FABP7,FABP7,BC012299,"","" 766,Regucalcin,2009-06-29 16:59:01 UTC,2009-08-13 06:39:43 UTC,Q15493,Calcium-binding protein which regulates Ca(2+) signaling by regulating Ca(2+)-dependent enzymatic activity in the liver and kidney. Decrease of RGN leads to the dysregulation of calcium signaling in the aged liver (By similarity),"",">Regucalcin MSSIKIECVLPENCRCGESPVWEEVSNSLLFVDIPAKKVCRWDSFTKQVQRVTMDAPVSSVALRQSGGYV ATIGTKFCALNWKEQSAVVLATVDNDKKNNRFNDGKVDPAGRYFAGTMAEETAPAVLERHQGALYSLFPD HHVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYSVDAFDYDLQTGQISNRRSVYKLEKEEQIPDGMCIDA EGKLWVACYNGGRVIRLDPVTGKRLQTVKLPVDKTTSCCFGGKNYSEMYVTCARDGMDPEGLLRQPEAGG IFKITGLGVKGIAPYSYAG",RGN,RC; Senescence marker protein 30; SMP-30,299,33253,6.14,">>> Function: enzyme regulator activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: Not Available || >>> Component: Not Available",Carbohydrate transport and metabolism,PF08450:SGL,HGNC:9989,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",RGN,RGN,BC073173,"","" 767,Triosephosphate isomerase,2009-06-29 17:01:11 UTC,2009-08-13 06:39:27 UTC,P60174,D-glyceraldehyde 3-phosphate = glycerone phosphate,"",">Triosephosphate isomerase MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKV TNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGIT EKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYG GSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ",TPI1,TIM; Triose-phosphate isomerase,249,26670,6.91,">>> Function: catalytic activity Function: isomerase activity Function: intramolecular oxidoreductase activity Function: intramolecular oxidoreductase activity, interconverting aldoses and ketoses Function: triose-phosphate isomerase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00121:TIM,HGNC:12009,"",,"","",None,None,Non Essential,1HTI,TPI1,TPI1,J04603,"","" 768,Selenium-binding protein 1,2009-06-29 17:02:05 UTC,2009-08-13 06:39:55 UTC,Q13228,Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity),"",">Selenium-binding protein 1 MATKCGNCGPGYSTPLEAMKGPREEIVYLPCIYRNTGTEAPDYLATVDVDPKSPQYCQVIHRLPMPNLKD ELHHSGWNTCSSCFGDSTKSRTKLVLPSLISSRIYVVDVGSEPRAPKLHKVIEPKDIHAKCELAFLHTSH CLASGEVMISSLGDVKGNGKGGFVLLDGETFEVKGTWERPGGAAPLGYDFWYQPRHNVMISTEWAAPNVL RDGFNPADVEAGLYGSHLYVWDWQRHEIVQTLSLKDGLIPLEIRFLHNPDAAQGFVGCALSSTIQRFYKN EGGTWSVEKVIQVPPKKVKGWLLPEMPGLITDILLSLDDRFLYFSNWLHGDLRQYDISDPQRPRLTGQLF LGGSIVKGGPVQVLEDEELKSQPEPLVVKGKRVAGGPQMIQLSLDGKRLYITTSLYSAWDKQFYPDLIRE GSVMLQVDVDTVKGGLKLNPNFLVDFGKEPLGPALAHELRYPGGDCSSDIWI",SELENBP1,56 kDa selenium-binding protein; SP56,472,52392,6.32,">>> Function: binding Function: selenium binding || >>> Process: Not Available || >>> Component: Not Available","",PF05694:SBP56,HGNC:10719,"Nucleus. Cytoplasm, cytosol. Membrane",,"","",None,None,Non Essential,"",SELENBP1,SELENBP1,BC009084,"","" 769,UDP-glucose 6-dehydrogenase,2009-06-29 17:02:33 UTC,2009-08-13 06:39:36 UTC,O60701,"Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate","",">UDP-glucose 6-dehydrogenase MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLF FSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESI RRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILT TNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKD VLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSS IYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMF KELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIPKFSLQDPPNK KPKV",UGDH,UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH,494,55025,7.13,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Cell wall/membrane/envelope biogenesis,"PF00984:UDPG_MGDP_dh PF03720:UDPG_MGDP_dh_C PF03721:UDPG_MGDP_dh_N",HGNC:12525,"",,"","",None,None,Non Essential,"",UGDH,UGDH,AF049126,"","" 770,Complement C3,2009-06-29 18:07:51 UTC,2009-08-13 06:39:56 UTC,P01024,"Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes","",">Complement C3 MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLS SEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLVSLQSGYLFIQTDKTIYT PGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQLGVLPLSWDIPELVNMGQWKIRAYY ENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQ RISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVT SPYQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPL SITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYY TYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCV GSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPG SGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRE NPMRFSCQRRTRFISLGEACKKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPES WLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVV RNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEV EVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRI LLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIK KGYTQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQE DAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVA IAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQR YYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGF TVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATM SILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVE LIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPG VDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSD FWGEKPNLSYIIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN",C3,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; Contains: RecName: Complement C3 beta chain; Contains: RecName: Complement C3 alpha chain; Contains: RecName: C3a anaphylatoxin; Contains: RecName: Complement C3b alpha' chain; Contains: RecName: Complement C3c alpha' chain fragment 1; Contains: RecName: Complement C3dg fragment; Contains: RecName: Complement C3g fragment; Contains: RecName: Complement C3d fragment; Contains: RecName: Complement C3f fragment; Contains: RecName: Complement C3c alpha' chain fragment 2,1663,187150,6.34,">>> Function: enzyme regulator activity Function: enzyme inhibitor activity Function: protease inhibitor activity Function: endopeptidase inhibitor activity || >>> Process: humoral immune response Process: complement activation Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response Process: inflammatory response || >>> Component: extracellular region","","PF00207:A2M PF07678:A2M_comp PF01835:A2M_N PF07703:A2M_N_2 PF07677:A2M_recep PF01821:ANATO PF01759:NTR",HGNC:1318,Secreted,,"","",1-22,None,Non Essential,1GHQ,C3,C3,AY513239,"","" 771,Calcium,2009-06-29 21:47:41 UTC,2009-06-29 21:47:41 UTC,Calcium,"","","","","","","","","","","","","","",,,,,,,,,,, 772,Myelin basic protein,2009-06-30 21:15:41 UTC,2009-08-13 06:39:33 UTC,P02686,"The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation","",">Myelin basic protein MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQDTAVTDSKRT ADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRP SQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKDSHHPARTAHYGSLPQKS HGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDA QGTLSKIFKLGGRDSRSGSPMARR",MBP,MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein,304,33117,10.46,">>> Function: structural molecule activity Function: structural constituent of myelin sheath || >>> Process: Not Available || >>> Component: Not Available","",PF01669:Myelin_MBP,HGNC:6925,Myelin membrane,,"","",None,None,Non Essential,1FV1,MBP,MBP,M63599,"","" 773,Neurofilament light polypeptide,2009-06-30 21:16:41 UTC,2009-08-13 06:39:44 UTC,P07196,"Neurofilaments usually contain three intermediate filament proteins:L, M, and H which are involved in the maintenance of neuronal caliber","",">Neurofilament light polypeptide MSSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLEN LDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYE QEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELE KRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWF KSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDT INKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFG RSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEE AAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKKD",NEFL,NF-L; Neurofilament triplet L protein; 68 kDa neurofilament protein,543,61517,4.32,">>> Function: structural molecule activity || >>> Process: Not Available || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: intermediate filament cytoskeleton Component: intermediate filament","Replication, recombination and repair","PF00038:Filament PF04732:Filament_head",HGNC:7739,"",,"","",None,None,Non Essential,"",NEFL,NEFL,S70309,"","" 774,Neurofilament heavy polypeptide,2009-06-30 21:18:00 UTC,2009-08-13 06:39:33 UTC,P12036,"Neurofilaments usually contain three intermediate filament proteins:L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins","",">Neurofilament heavy polypeptide MMSFGGADALLGAPFAPLHGGGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSASPSRFRGAGA ASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRS AMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAE AARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEG HAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELE DRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPF SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGE EEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA EVKSPEKAKSPTKEEAKSPEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKA KSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVK VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK AKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK",NEFH,NF-H; Neurofilament triplet H protein; 200 kDa neurofilament protein,1026,112480,5.82,">>> Function: structural molecule activity || >>> Process: Not Available || >>> Component: Not Available","Translation, ribosomal structure and biogenesis","PF07142:DUF1388 PF00038:Filament",HGNC:7737,"",,"","",None,None,Non Essential,"",NEFH,NEFH,BC073969,"","" 775,Neurofilament medium polypeptide,2009-06-30 21:18:51 UTC,2009-08-13 06:39:45 UTC,P07197,"Neurofilaments usually contain three intermediate filament proteins:L, M, and H which are involved in the maintenance of neuronal caliber","",">Neurofilament medium polypeptide MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSS AESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQ ASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDI EEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESH SDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEE RHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSIT GPLYTHRPPITISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAASMKEEKKE AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSE KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPV PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQ EKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD EKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVK EVTQSD",NEFM,NF-M; Neurofilament triplet M protein; 160 kDa neurofilament protein; Neurofilament 3,916,102449,4.58,">>> Function: structural molecule activity || >>> Process: Not Available || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: intermediate filament cytoskeleton Component: intermediate filament","Replication, recombination and repair","PF00038:Filament PF04732:Filament_head",HGNC:7734,"",,"","",None,None,Non Essential,"",NEFM,NEFM,Y00067,"","" 776,DNA-directed RNA polymerase II subunit RPB1,2009-07-03 18:00:06 UTC,2009-08-13 06:39:34 UTC,P24928,"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing","",">DNA-directed RNA polymerase II subunit RPB1 MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPRQGVIERTGR CQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPKKR LTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQ EKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKL ADIVKINNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRV RGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTT PYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEV MNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVV ENGELIMGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQ DIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMV VSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLK PSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLP CNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLC SRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLG VPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQ EWVNVYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKA LQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLAL LCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGC FDLLLDAEKCKYGMEIPTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMT PGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTP QSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSP TSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTP SSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSP TSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPA ISPDDSDEEN",POLR2A,RNA polymerase II subunit B1; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit,1970,217208,7.38,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: transcription, DNA-dependent Process: transcription from RNA polymerase II promoter Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: protein complex Component: RNA polymerase complex Component: DNA-directed RNA polymerase II, core complex Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus",Transcription,"PF04997:RNA_pol_Rpb1_1 PF00623:RNA_pol_Rpb1_2 PF04983:RNA_pol_Rpb1_3 PF05000:RNA_pol_Rpb1_4 PF04998:RNA_pol_Rpb1_5 PF04992:RNA_pol_Rpb1_6 PF04990:RNA_pol_Rpb1_7 PF05001:RNA_pol_Rpb1_R",HGNC:9187,Nucleus,,REACT_1788-Transcription;,"",None,None,Non Essential,"",POLR2A,POLR2A,X74874,"","" 777,DNA-directed RNA polymerase II subunit RPB3,2009-07-03 18:00:47 UTC,2009-08-13 06:39:30 UTC,P19387,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity),"",">DNA-directed RNA polymerase II subunit RPB3 MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLHDEFIAHRLGL IPLISDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDLISNSPRVIPVTSRNRDNDPN DYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSEYSE LDEDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN",POLR2C,RNA polymerase II subunit B3; RNA polymerase II subunit 3; DNA-directed RNA polymerase II subunit C; DNA-directed RNA polymerase II 33 kDa polypeptide; RPB33; RPB31,275,31441,4.54,">>> Function: protein binding Function: protein dimerization activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus",Transcription,"PF01000:RNA_pol_A_bac PF01193:RNA_pol_L",HGNC:9189,Nucleus,,REACT_1788-Transcription;,"",None,None,Non Essential,"",POLR2C,POLR2C,BC028157,"","" 778,DNA-directed RNA polymerase II subunit RPB7,2009-07-03 18:01:15 UTC,2009-08-13 06:39:30 UTC,P62487,"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA","",">DNA-directed RNA polymerase II subunit RPB7 MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPV KYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTMDEDIVIQQD DEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS",POLR2G,RNA polymerase II subunit B7; DNA-directed RNA polymerase II subunit G; DNA-directed RNA polymerase II 19 kDa polypeptide,172,19295,5.23,">>> Function: binding Function: nucleic acid binding Function: RNA binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: Not Available",Transcription,"PF03876:RNA_pol_Rpb7_N PF00575:S1",HGNC:9194,Nucleus,,REACT_1788-Transcription;,"",None,None,Non Essential,"",POLR2G,POLR2G,BC112164,"","" 779,DNA-directed RNA polymerase II subunit RPB11-a,2009-07-03 18:01:57 UTC,2009-08-13 06:39:40 UTC,P52435,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity),"",">DNA-directed RNA polymerase II subunit RPB11-a MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHK IIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE",POLR2J,RNA polymerase II subunit B11-a; RPB11a; DNA-directed RNA polymerase II subunit J-1; DNA-directed RNA polymerase II 13.3 kDa polypeptide,117,13293,5.68,">>> Function: nucleic acid binding Function: DNA binding Function: binding Function: protein binding Function: protein dimerization activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: Not Available",Transcription,PF01193:RNA_pol_L,HGNC:9197,Nucleus (By similarity),,REACT_1788-Transcription;,"",None,None,Non Essential,"",POLR2J,POLR2J,BC065711,"","" 780,DNA-directed RNA polymerase II subunit RPB9,2009-07-03 18:02:22 UTC,2009-08-13 06:39:57 UTC,P36954,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity),"",">DNA-directed RNA polymerase II subunit RPB9 MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIA DVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE",POLR2I,RNA polymerase II subunit B9; DNA-directed RNA polymerase II subunit I; DNA-directed RNA polymerase II 14.5 kDa polypeptide; RPB14.5,125,14523,4.79,">>> Function: transcription factor activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: transcription, DNA-dependent Process: RNA elongation Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: Not Available",Transcription,PF02150:RNA_POL_M_15KD,HGNC:9196,Nucleus (By similarity),,REACT_1788-Transcription;,"",None,None,Non Essential,"",POLR2I,POLR2I,BC067794,"","" 781,DNA-directed RNA polymerase II subunit RPB4,2009-07-03 18:03:02 UTC,2009-08-13 06:39:36 UTC,O15514,"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity)","",">DNA-directed RNA polymerase II subunit RPB4 MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTAR FSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSF QY",POLR2D,RNA polymerase II subunit B4; DNA-directed RNA polymerase II subunit D; DNA-directed RNA polymerase II 16 kDa polypeptide,142,16311,4.46,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: Not Available","",PF03874:RNA_pol_Rpb4,HGNC:9191,Nucleus (By similarity),,REACT_1788-Transcription;,"",None,None,Non Essential,"",POLR2D,POLR2D,BC093797,"","" 782,"DNA-directed RNA polymerases I, II, and III subunit RPABC2",2009-07-03 18:04:35 UTC,2009-08-13 06:39:41 UTC,P61218,"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity)","",">DNA-directed RNA polymerases I, II, and III subunit RPABC2 MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKYERARVLGTRA LQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGVDELIITD",POLR2F,"RNA polymerases I, II, and III subunit ABC2; DNA-directed RNA polymerase II subunit F; DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide; RPABC14.4; RPB14.4; RPB6; RPC15",127,14478,3.84,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription Process: transcription, DNA-dependent || >>> Component: protein complex Component: RNA polymerase complex",Transcription,PF01192:RNA_pol_Rpb6,HGNC:9193,Nucleus,,REACT_1788-Transcription;,"",None,None,Non Essential,1QKL,POLR2F,POLR2F,BC003582,"","" 783,"DNA-directed RNA polymerases I, II, and III subunit RPABC1",2009-07-03 18:05:02 UTC,2009-08-13 06:39:27 UTC,P19388,"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity)","",">DNA-directed RNA polymerases I, II, and III subunit RPABC1 MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTVLVAHNDDPTD QMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINIT EHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ",POLR2E,"RNA polymerases I, II, and III subunit ABC1; DNA-directed RNA polymerase II subunit E; RPB5; DNA-directed RNA polymerase II 23 kDa polypeptide; XAP4",210,24552,5.76,">>> Function: binding Function: nucleic acid binding Function: DNA binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: Not Available",Transcription,"PF01191:RNA_pol_Rpb5_C PF03871:RNA_pol_Rpb5_N",HGNC:9192,Nucleus (By similarity),,REACT_1788-Transcription;,"",None,None,Non Essential,"",POLR2E,POLR2E,BC034144,"","" 784,"DNA-directed RNA polymerases I, II, and III subunit RPABC3",2009-07-03 18:05:24 UTC,2009-08-13 06:39:30 UTC,P52434,"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively","",">DNA-directed RNA polymerases I, II, and III subunit RPABC3 MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTL DDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGGLLMRLQGDANNLHGFEVDSR VYLLMKKLAF",POLR2H,"RNA polymerases I, II, and III subunit ABC3; DNA-directed RNA polymerase II subunit H; DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide; RPB17; hRPB8; RPB8",150,17143,4.27,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: Not Available","",PF03870:RNA_pol_Rpb8,HGNC:9195,"Nucleus, nucleolus",,REACT_1788-Transcription;,"",None,None,Non Essential,"",POLR2H,POLR2H,BC000739,"","" 785,"DNA-directed RNA polymerases I, II, and III subunit RPABC5",2009-07-03 18:06:33 UTC,2009-08-13 06:39:49 UTC,P62875,"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity)","",">DNA-directed RNA polymerases I, II, and III subunit RPABC5 MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLLNYAPLEK",POLR2L,"RNA polymerases I, II, and III subunit ABC5; DNA-directed RNA polymerase III subunit L; RPB10; DNA-directed RNA polymerase II 7.6 kDa polypeptide; RPB7.6",67,7645,7.92,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription || >>> Component: Not Available",Transcription,PF01194:RNA_pol_N,HGNC:9199,Nucleus,,REACT_1788-Transcription;,"",None,None,Non Essential,"",POLR2L,POLR2L,Z47728,"","" 786,DNA-directed RNA polymerase II subunit RPB11-b2,2009-07-03 18:07:00 UTC,2009-08-13 06:39:27 UTC,Q9H1A7,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity),"",">DNA-directed RNA polymerase II subunit RPB11-b2 MNAPPAFESFLLFEGEKITINKDTKVPNACLFTMNKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHKI IIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRTCLLPLRLLP",POLR2J3,RNA polymerase II subunit B11-b2; RPB11b2; DNA-directed RNA polymerase II subunit J3,115,13092,6.25,">>> Function: nucleic acid binding Function: DNA binding Function: binding Function: protein binding Function: protein dimerization activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: Not Available",Transcription,PF01193:RNA_pol_L,"",Nucleus (By similarity),,"","",None,None,Non Essential,"",POLR2J3,"",AC004084,"","" 787,DNA-directed RNA polymerase II subunit RPB11-b1,2009-07-03 18:08:17 UTC,2009-08-13 06:39:28 UTC,Q9GZM3,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity),"",">DNA-directed RNA polymerase II subunit RPB11-b1 MNAPPAFESFLLFEGEKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHKI IIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRTCLLPLRLLP",POLR2J2,RNA polymerase II subunit B11-b1; RPB11b1; DNA-directed RNA polymerase II subunit J2,115,13074,6.25,">>> Function: nucleic acid binding Function: DNA binding Function: binding Function: protein binding Function: protein dimerization activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: Not Available",Transcription,PF01193:RNA_pol_L,"",Nucleus (By similarity),,"","",None,None,Non Essential,"",POLR2J2,"",BC086857,"","" 788,5-hydroxytryptamine 2A receptor,2009-07-05 20:11:43 UTC,2009-08-13 06:39:36 UTC,P28223,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production","",">5-hydroxytryptamine receptor 2A MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLH LQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYR WPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPI PVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLAS FSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICK ESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV",HTR2A,5-HT-2A; 5-HT-2; Serotonin receptor 2A,471,52604,7.72,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5293,Cell membrane,,"","",None,"76-99 111-132 148-171 192-215 234-254 325-346 363-384",Non Essential,"",HTR2A,HTR2A,S50130,"","" 789,5-hydroxytryptamine 2C receptor,2009-07-05 20:12:48 UTC,2009-08-13 06:39:28 UTC,P28335,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system","",">5-hydroxytryptamine receptor 2C MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGG NILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTA SIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLN DPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANP NQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLL NVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV",HTR2C,5-HTR2C; 5-HT-2C; 5-HT2C; 5HT-1C; Serotonin receptor 2C,458,51822,9.11,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5295,Cell membrane,,"","",None,"53-78 90-110 128-150 171-193 214-235 312-333 349-371",Non Essential,"",HTR2C,HTR2C,BC095543,"","" 790,5-hydroxytryptamine 2B receptor,2009-07-05 20:13:26 UTC,2009-08-13 06:39:45 UTC,P41595,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system","",">5-hydroxytryptamine receptor 2B MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIG GNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFST ASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLT KERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEK VAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLC DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV",HTR2B,5-HT-2B; Serotonin receptor 2B,481,54299,9.47,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5294,Cell membrane,,"","",None,"57-79 92-113 130-151 172-192 217-239 325-345 361-383",Non Essential,"",HTR2B,HTR2B,BC063123,"","" 791,Insulin receptor,2009-07-06 06:27:26 UTC,2009-08-13 06:39:36 UTC,P06213,"This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1","",">Insulin receptor MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRP EDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNIT RGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCW THSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRC VNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDS VTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNG DKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVD IDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPIS VSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQS EYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNV TVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERG CRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLR KRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEA ETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP EAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLD RSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS",INSR,IR; CD220 antigen; Contains: RecName: Insulin receptor subunit alpha; Contains: RecName: Insulin receptor subunit beta,1382,156308,6.18,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: epidermal growth factor receptor activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein-tyrosine kinase activity Function: transmembrane receptor protein tyrosine kinase activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: enzyme linked receptor protein signaling pathway Process: transmembrane receptor protein tyrosine kinase signaling pathway Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: cell Component: membrane","","PF00041:fn3 PF00757:Furin-like PF07714:Pkinase_Tyr PF01030:Recep_L_domain",HGNC:6091,Membrane,,"","",1-27,957-979,Non Essential,1IRK,INSR,INSR,M27197,"","" 792,Small conductance calcium-activated potassium channel protein 1,2009-07-06 21:36:05 UTC,2009-08-13 06:39:30 UTC,Q92952,Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity),"",">Small conductance calcium-activated potassium channel protein 1 MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDE DDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSF ALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWT ARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTI CPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLT GIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARV RKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLD ALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG",KCNN1,SK1,543,59988,9.05,">>> Function: small conductance calcium-activated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity Function: binding Function: protein binding Function: calmodulin binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02888:CaMBD PF07885:Ion_trans_2 PF03530:SK_channel",HGNC:6290,Membrane,,"","",None,"111-131 140-160 179-199 228-248 277-297 346-366",Non Essential,"",KCNN1,KCNN1,BC075037,"","" 793,Small conductance calcium-activated potassium channel protein 2,2009-07-06 21:36:05 UTC,2009-08-13 06:39:53 UTC,Q9H2S1,Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin,"",">Small conductance calcium-activated potassium channel protein 2 MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSK PEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALI FGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMT YERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLF TDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMW LISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVK NAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMY DMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRS SSRRRRSSSTAPPTSSESS",KCNN2,SK2,579,63761,9.99,">>> Function: small conductance calcium-activated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity Function: binding Function: protein binding Function: calmodulin binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02888:CaMBD PF07885:Ion_trans_2 PF03530:SK_channel",HGNC:6291,Membrane,,"","",None,"138-158 168-188 214-234 256-276 305-325 345-365 374-394",Non Essential,1KKD,KCNN2,KCNN2,BC117456,"","" 794,Small conductance calcium-activated potassium channel protein 3,2009-07-06 21:36:05 UTC,2009-08-13 06:39:29 UTC,Q9UGI6,Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin,"",">Small conductance calcium-activated potassium channel protein 3 MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQ QQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDH LLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEG QPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRA LFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLF VIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRL YLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYH DQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHV HNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQA NTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEA RGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC",KCNN3,SKCa3; SK3,736,82027,9.25,">>> Function: small conductance calcium-activated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity Function: binding Function: protein binding Function: calmodulin binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02888:CaMBD PF07885:Ion_trans_2 PF03530:SK_channel",HGNC:6292,Membrane,,"","",None,"293-313 320-340 371-391 410-430 459-479 499-519 528-548",Non Essential,1KKD,KCNN3,KCNN3,AL954342,"","" 795,Glutamate receptor 1,2009-07-06 21:36:06 UTC,2009-08-13 06:39:37 UTC,P42262,"Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist","",">Glutamate receptor 2 MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANS FAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLI EYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILD CERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTL EEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQ VQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTT ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVY GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV LFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT LIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEP SVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLA VLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR AEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI",GRIA2,"GluR-2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2; AMPA-selective glutamate receptor 2",883,98822,7.66,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Amino acid transport and metabolism,"PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4572,Cell membrane,,"","",1-24,"544-564 625-645 813-833",Non Essential,1WVJ,GRIA2,GRIA2,BC010574,"","" 796,Glutamate receptor 1,2009-07-06 21:36:06 UTC,2009-08-13 06:39:46 UTC,P42261,"Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist","",">Glutamate receptor 1 MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEM TYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQDALISIIDHY KWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLN AILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTR VDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLT GNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAV APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF SPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSY TANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTT EEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQ GLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK GFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMPLGATGL",GRIA1,"GluR-1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; AMPA-selective glutamate receptor 1",906,101507,7.78,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4571,Cell membrane,,"","",1-18,"537-557 618-638 806-826",Non Essential,1WVJ,GRIA1,GRIA1,BC111734,"","" 797,Glutamate receptor 3,2009-07-06 21:36:06 UTC,2009-08-13 06:39:33 UTC,P42263,"Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist","",">Glutamate receptor 3 MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFH LNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQ MRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMD RRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMV QQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQ GIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASS ENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIW NGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV FAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSG RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYE KMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPK GSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMM VALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI",GRIA3,"GluR-3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3; AMPA-selective glutamate receptor 3",894,101158,8.74,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4573,Cell membrane,,"","",1-28,"553-573 636-656 824-844",Non Essential,1XHY,GRIA3,GRIA3,AL035426,"","" 798,Glutamate receptor 4,2009-07-06 21:36:07 UTC,2009-08-13 06:39:55 UTC,P48058,"Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist","",">Glutamate receptor 4 MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTAPNASEAPFNLVPHVDN IETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRG ALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFV IDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWK KLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGKSGDCLANPAAPWGQGIDMERTLK QVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVT TIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELV YGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSV VLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFF TLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAE PSVFTRTTAEGVARVRKSKGKFAFLLESTMNDNIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNL AVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS RAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP",GRIA4,"GluR-4; GluR4; GluR-D; Glutamate receptor ionotropic, AMPA 4; AMPA-selective glutamate receptor 4",902,100811,8.32,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Amino acid transport and metabolism,"PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4574,Cell membrane,,"","",1-20,"545-565 626-646 814-834",Non Essential,1XHY,GRIA4,GRIA4,U16129,"","" 799,"Glutamate receptor, ionotropic kainate 1",2009-07-06 21:36:07 UTC,2009-08-13 06:39:40 UTC,P39086,"Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus","",">Glutamate receptor, ionotropic kainate 1 MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRT LMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSV DNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNK DAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGF RLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHR HKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGI WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNIL GFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKP NGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFG VGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAV RDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQI GGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI VLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECGKLIREERGIR KQSSVHTV",GRIK1,Glutamate receptor 5; GluR-5; GluR5; Excitatory amino acid receptor 3; EAA3,918,103982,7.09,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4579,Cell membrane,,"","",1-30,"577-597 654-674 835-855",Non Essential,1YAE,GRIK1,GRIK1,AJ249208,"","" 800,"Glutamate receptor, ionotropic kainate 2",2009-07-06 21:36:07 UTC,2009-08-13 06:39:29 UTC,Q13002,"Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus","",">Glutamate receptor, ionotropic kainate 2 MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTL LPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSD NKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKD AKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFR ILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRH KPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGA QDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLS PDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKA LSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKIS TYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPM GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA",GRIK2,Glutamate receptor 6; GluR-6; GluR6; Excitatory amino acid receptor 4; EAA4,908,102585,8.01,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4580,Cell membrane,,"","",1-31,"562-582 636-656 820-840",Non Essential,1YAE,GRIK2,GRIK2,AJ301610,"","" 801,"Glutamate receptor, ionotropic kainate 3",2009-07-06 21:36:07 UTC,2009-08-13 06:39:28 UTC,Q13003,Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA,"",">Glutamate receptor, ionotropic kainate 3 MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRN RTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHH PLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPID SDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLT GFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQC HRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGK YGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNP LSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMP KALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSK ISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTP MGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMAC STSLAPVFP",GRIK3,Glutamate receptor 7; GluR-7; GluR7; Excitatory amino acid receptor 5; EAA5,919,104038,7.55,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4581,Cell membrane,,"","",1-31,"564-584 637-657 821-841",Non Essential,1YAE,GRIK3,GRIK3,S69349,"","" 802,"Glutamate receptor, ionotropic kainate 4",2009-07-06 21:36:07 UTC,2009-08-13 06:39:41 UTC,Q16099,Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists,"",">Glutamate receptor, ionotropic kainate 4 MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFE LLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRFTTLNLH PSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDD KTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQE FAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNY LRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVV TTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELI ARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSC VLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTL IIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPS VFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQL QENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVS VCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAA LVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE",GRIK4,Glutamate receptor KA-1; KA1; Excitatory amino acid receptor 1; EAA1,956,107247,6.71,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Amino acid transport and metabolism,"PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4582,Cell membrane,,"","",1-20,"546-566 624-644 805-825",Non Essential,"",GRIK4,GRIK4,CH471065,"","" 803,"Glutamate receptor, ionotropic kainate 5",2009-07-06 21:36:07 UTC,2009-08-13 06:39:40 UTC,Q16478,"Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD","",">Glutamate receptor, ionotropic kainate 5 MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFEL QRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYP SNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDK VSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEF VRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYL RMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVT TILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELIN RKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCV LFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLI IISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSV FVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQ ENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVS VCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLL DDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEATSPPRPRPGPAGPRELAEHE",GRIK5,Glutamate receptor KA-2; KA2; Excitatory amino acid receptor 2; EAA2,980,109266,8.27,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Amino acid transport and metabolism,"PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4583,Cell membrane,,"","",1-14,"545-565 623-643 804-824",Non Essential,"",GRIK5,GRIK5,CH471126,"","" 804,Neurexin-1-alpha,2009-07-06 21:36:18 UTC,2009-08-13 06:39:36 UTC,Q9ULB1,Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling,"",">Neurexin-1-alpha MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYF DDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEV KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPN SGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKE EYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGA FEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESF ISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGT IKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTE VWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVC DCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFK TKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSN KPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQ GCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN DPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVK FNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQG QPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLAT STARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSST TGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKN KDKEYYV",NRXN1,Neurexin I-alpha,1477,161884,5.69,"","","PF00008:EGF PF02210:Laminin_G_2",HGNC:8008,Membrane,,"","",1-30,1402-1422,Non Essential,1C4R,NRXN1,NRXN1,AC068715,"","" 805,Neurexin-2-alpha,2009-07-06 21:36:18 UTC,2009-08-13 06:39:55 UTC,Q9P2S2,Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling,"",">Neurexin-2-alpha MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLD DGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSK RREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPAR NPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQ PTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVI NLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTM LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVA ALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLD GHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGG LPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCR NGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMM ATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARF GLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFD LGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFS NLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTC DCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDY LQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERL AIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPN VRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVAS AECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARR PPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRT DGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLP TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV",NRXN2,Neurexin II-alpha,1712,184984,5.72,"","Cell cycle control, cell division, chromosome partitioning","PF00008:EGF PF02210:Laminin_G_2",HGNC:8009,Membrane,,"","",1-28,1637-1657,Non Essential,"",NRXN2,NRXN2,AC044790,"","" 806,Neurexin-3-alpha,2009-07-06 21:36:18 UTC,2009-08-13 06:39:28 UTC,Q9Y4C0,Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling,"",">Neurexin-3-alpha MSSTLHSVFFTLKVSILLGSLLGLCLGLEFMGLPNQWARYLRWDASTRSDLSFQFKTNVSTGLLLYLDDG GVCDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGELQPQRPY MDVVSDLFLGGVPTDIRPSALTLDGVQAMPGFKGLILDLKYGNSEPRLLGSRGVQMDAEGPCGERPCENG GICFLLDGHPTCDCSTTGYGGKLCSEDVSQDPGLSHLMMSEQAREENVATFRGSEYLCYDLSQNPIQSSS DEITLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNGKFNDNAWHDVKVTRN LRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELS RLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGK PQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNS RRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQ NAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPM VMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQK LNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMF NGLLYIDLCKNGDIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILF NSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVI NGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIKRGCEGPS TTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAV GFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNA TLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSV RLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVEC EPSTTGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGC DDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETS RTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRN VPTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYIS NSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV",NRXN3,Neurexin III-alpha,1643,180600,5.25,"","","PF00008:EGF PF02210:Laminin_G_2",HGNC:8010,Membrane,,"","",1-27,1569-1589,Non Essential,"",NRXN3,NRXN3,AC026888,"","" 807,Neurexin-1-beta,2009-07-06 21:36:18 UTC,2009-08-13 06:39:59 UTC,P58400,Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling,"",">Neurexin-1-beta MYQRMLRCGAELGSPGGGGGGGGGGGAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHS VPIAIYRSPASLRGGHAGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLG DYLELHIHQGKIGVKFNIGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTI FNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGDVRLVGEVPSSXTTESTATAMQS EMSTSIMETTTTLATSTARRGKPPTKEPISQTTGDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGRE PYPGSAEVIRESSSTTGMVVGIVAAAALCILILLCAMNKCRNRDEGSYHVDESRNYISNSAQSNGAVVKE KQPSSAKSSNKNKKNKDKEYYV",NRXN1,Neurexin I-beta,442,46575,7.89,"","",PF02210:Laminin_G_2,HGNC:8008,Membrane,,"","",1-50,364-386,Non Essential,1C4R,NRXN1,NRXN1,"","","" 808,Neurexin-2-beta,2009-07-06 21:36:18 UTC,2009-08-13 06:39:27 UTC,P58401,Neuronal cell surface protein that may be involved in cell recognition and cell adhesion,"",">Neurexin-2-beta MPPGGSGPGGCPRRPPALAGPLPPPPPPPPPPLLPLLPLLLLLLLGAAEGARVSSSLSTTHHVHHFHSKH GTVPIAINRMPFLTRGGHAGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASG LGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFD NERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAE SDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDL LVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPP AARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRP NLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGF PHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNY ISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV",NRXN2,Neurexin II-beta,666,70928,6.33,"","Cell cycle control, cell division, chromosome partitioning",PF02210:Laminin_G_2,HGNC:8009,Membrane,,"","",1-50,591-611,Non Essential,"",NRXN2,NRXN2,"","","" 809,Neurexin-3-beta,2009-07-06 21:36:18 UTC,2009-08-13 06:39:56 UTC,Q9HDB5,Neuronal cell surface protein that may be involved in cell recognition and cell adhesion,"",">Neurexin-3-beta MHLRIHARRSPPRRPAWTLGIWFLFWGCIVSSVWSSSNVASSSSTSSSPGSHSQHEHHFHGSKHHSVPIS IYRSPVSLRGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQ LHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQ AQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTT VMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTTGGELVIPLLVEDPLATPPIA TRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDD EDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPK LPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESS STTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQK NKDREYYV",NRXN3,Neurexin III-beta,638,69407,7.23,"","",PF02210:Laminin_G_2,HGNC:8010,Membrane,,"","",1-35,564-584,Non Essential,"",NRXN3,NRXN3,AC018514,"","" 810,Latrophilin-1,2009-07-06 21:36:19 UTC,2009-08-13 06:39:48 UTC,O94910,"Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity)","",">Latrophilin-1 MARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKI CDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYKVEQKVFVC PGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTEYASWEDYVAARHTTTYRLPNR VDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVI YATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNT NANREEPVSLTFPNPYQFISSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPT PLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPVPSTRRPPAPNLHVSPELFCEPREVRRVQW PATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIASELARH TRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRP EALESWKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFPQE EYPRKNSIQLSAKTIKQNSRNGVVKVVFILYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAA SINKESSRVFLMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTN FAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLF LVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGI AAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWA LGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIR SPPGGTHGSLKTSAMRSNTRYYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPV LQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFP PGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEEEAGGPGGADR AEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDS SPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHEGYLAAPGLEGPGPDGDGQMQL VTSL",LPHN1,Calcium-independent alpha-latrotoxin receptor 1; Lectomedin-2,1474,162718,6.57,">>> Function: binding Function: carbohydrate binding Function: sugar binding Function: latrotoxin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity || >>> Process: neuropeptide signaling pathway Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane","","PF00002:7tm_2 PF02140:Gal_Lectin PF01825:GPS PF02793:HRM PF02354:Latrophilin PF02191:OLF",HGNC:20973,Cell membrane,,"","",1-24,"859-879 894-914 921-941 965-985 1003-1023 1051-1071 1076-1096",Non Essential,"",LPHN1,LPHN1,BC007587,"","" 811,Latrophilin-2,2009-07-06 21:36:19 UTC,2009-08-13 06:39:32 UTC,O95490,"Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity)","",">Latrophilin-2 MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDK ICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTYKYLEVQYECVPYIFVCPGTL KAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRTDTLIEYASLEDFQNSRQTTTYKLPNRVDGT GFVVYDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATE QNNGMIVISQLNPYTLRFEATWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNR GEYVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIIST TSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWPQTQRGMMVER PCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELAKHTKGPVFAGDVS SSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRAYLKAIVDTVDNLLRPEALESWKHMNS SEQAHTATMLLDTLEEGAFVLADNLLEPTRVSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLS ANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDP VLFTLPHIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKD GVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYAIAC PIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTEK ACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRLENIKSWVLGAFALLCLLGLT WSFGLLFINEETIVMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKAS TTRTSARYSSGTQSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTL LAETVVCNAPSAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFE KMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHHKELEAPLIPQ RTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRDSPYPESSPDMEEDLSPSRRS ENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKEGCIPEGDVREGQMQLVTSL",LPHN2,Calcium-independent alpha-latrotoxin receptor 2; Latrophilin homolog 1; Lectomedin-1,1459,163350,6.39,">>> Function: binding Function: carbohydrate binding Function: sugar binding Function: latrotoxin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity || >>> Process: neuropeptide signaling pathway Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane","","PF00002:7tm_2 PF02140:Gal_Lectin PF01825:GPS PF02793:HRM PF02354:Latrophilin PF02191:OLF",HGNC:18582,Cell membrane,,"","",1-25,"852-872 881-901 908-928 953-973 991-1011 1038-1058 1063-1083",Non Essential,"",LPHN2,LPHN2,AB018329,"","" 812,Latrophilin-3,2009-07-06 21:36:19 UTC,2009-08-13 06:39:50 UTC,Q9HAR2,"","",">Latrophilin-3 MWPSQLLIFMMLLAPIIHAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDP AQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLK GVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTG FVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQ NNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKD SLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELE RPSVKDISTTGPLGMGSTTTSTTLRTTTLSPGRSTTPSVSGRRNRSTSTPSPAVEVLDDMTTHLPSASSQ IPALEESCEAVEAREIMWFKTRQGQIAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPWVNHITQ KLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLTPGGKDSAARSLNKAMVETVN NLLQPQALNAWRDLTTSDQLRAATMLLHTVEESAFVLADNLLKTDIVRENTDNIKLEVARLSTEGNLEDL KFPENMGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEALSTNHSVIVNSPVIT AAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNH LTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFVA ELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPAL IVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNI KSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHC CSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARD TSVMDTLPLNGNHGNSYSIASGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQN RNLMNKLVNNLGSGREDDAIVLDDATSFNHEESLGLELIHEESDAPLLPPRVYSTENHQPHHYTRRRIPQ DHSESFFPLLTNEHTEDLQSPHRDSLYTSMPTLAGVAATESVTTSTQTEPPPAKCGDAEDVYYKSMPNLG SRNHVHQLHTYYQLGRGSSDGFIVPPNKDGTPPEGSSKGPAHLVTSL",LPHN3,Calcium-independent alpha-latrotoxin receptor 3; Lectomedin-3,1447,161814,6.41,">>> Function: binding Function: carbohydrate binding Function: sugar binding Function: latrotoxin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity || >>> Process: neuropeptide signaling pathway Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane","","PF00002:7tm_2 PF02140:Gal_Lectin PF01825:GPS PF02793:HRM PF02354:Latrophilin PF02191:OLF",HGNC:20974,Cell membrane,,"","",1-19,"867-889 902-919 934-956 969-988 1008-1030 1050-1072 1082-1104",Non Essential,"",LPHN3,LPHN3,AB018311,"","" 813,Calcium-activated potassium channel subunit beta-1,2009-07-07 21:55:14 UTC,2009-08-13 06:39:50 UTC,Q16558,"Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate","",">Calcium-activated potassium channel subunit beta-1 MVKKLVMAQKRGETRALCLGVTMVVCAVITYYILVTTVLPLYQKSVWTQESKCHLIETNIRDQEELEGKK VPQYPCLWVNVSAAGRWAVLYHTEDTRDQNQQCSYIPGSVDNYQTARADVEKVRAKFQEQQVFYCFSAPR GNETSVLFQRLYGPQALLFSLFWPTFLLTGGLLIIAMVKSNQYLSILAAQK",KCNMB1,"Calcium-activated potassium channel, subfamily M subunit beta-1; Calcium-activated potassium channel subunit beta; Maxi K channel subunit beta-1; BK channel subunit beta-1; BKbeta1; BKbeta; Hbeta1; K(VCA)beta-1; Slo-beta-1; Slo-beta; Charybdotoxin receptor subunit beta-1",191,21799,8.76,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF03185:CaKB,HGNC:6285,Membrane,,"","",None,"19-39 158-178",Non Essential,"",KCNMB1,KCNMB1,BC025707,"","" 814,Calcium-activated potassium channel subunit beta-2,2009-07-07 21:55:14 UTC,2009-08-13 06:39:59 UTC,Q9Y691,"Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons","",">Calcium-activated potassium channel subunit beta-2 MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLL RSYMQSVWTEESQCTLLNASITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGEKLLLYHTEETIKINQ KCSYIPKCGKNFEESMSLVNVVMENFRKYQHFSCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGG VAIVAMVKLTQYLSLLCERIQRINR",KCNMB2,"Calcium-activated potassium channel, subfamily M subunit beta-2; Maxi K channel subunit beta-2; BK channel subunit beta-2; BKbeta2; Hbeta2; Hbeta3; K(VCA)beta-2; Slo-beta-2; Charybdotoxin receptor subunit beta-2",235,27130,8.47,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","","PF03185:CaKB PF09303:KcnmB2_inactiv",HGNC:6286,Membrane,,"","",None,"47-67 195-215",Non Essential,1JO6,KCNMB2,KCNMB2,BC017825,"","" 815,Calcium-activated potassium channel subunit beta-3,2009-07-07 21:55:14 UTC,2009-08-13 06:39:41 UTC,Q9NPA1,"Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer","",">Calcium-activated potassium channel subunit beta-3 MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFAMMGFSV LMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQVFVNLSHPGQKAL LHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFSCFYSPASQSEDVILIKKYDQMAI FHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS",KCNMB3,"Calcium-activated potassium channel, subfamily M subunit beta-3; Maxi K channel subunit beta-3; BK channel subunit beta-3; BKbeta3; Hbeta3; K(VCA)beta-3; Slo-beta-3; Charybdotoxin receptor subunit beta-3",279,31604,7.31,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF03185:CaKB,HGNC:6287,Membrane,,"","",None,"61-81 208-228",Non Essential,"",KCNMB3,KCNMB3,AF170916,"","" 816,Calcium-activated potassium channel subunit beta-4,2009-07-07 21:55:14 UTC,2009-08-13 06:39:33 UTC,Q86W47,"Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations","",">Calcium-activated potassium channel subunit beta-4 MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTF TCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDE IGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS",KCNMB4,"Calcium-activated potassium channel, subfamily M subunit beta-4; Maxi K channel subunit beta-4; BK channel subunit beta-4; BKbeta4; Hbeta4; K(VCA)beta-4; Slo-beta-4; Charybdotoxin receptor subunit beta-4",210,23949,6.75,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF03185:CaKB,HGNC:6289,Membrane,,"","",None,"20-40 168-188",Non Essential,"",KCNMB4,KCNMB4,BC050621,"","" 817,Intermediate conductance calcium-activated potassium channel protein 4,2009-07-07 21:55:15 UTC,2009-08-13 06:39:51 UTC,O15554,Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin,"",">Intermediate conductance calcium-activated potassium channel protein 4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTF LLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQP WPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLG LTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTAL LVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINA FRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP EPSQQSK",KCNN4,SK4; KCa4; IKCa1; IK1; Putative Gardos channel,427,47696,10.39,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: potassium channel activity Function: calcium-activated potassium channel activity Function: binding Function: protein binding Function: calmodulin binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: protein complex Component: voltage-gated potassium channel complex Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Inorganic ion transport and metabolism,"PF02888:CaMBD PF07885:Ion_trans_2 PF03530:SK_channel",HGNC:6293,Membrane,,"","",None,"29-49 59-79 108-128 143-163 207-227 241-261 265-285",Non Essential,"",KCNN4,KCNN4,AF053403,"","" 818,Chloride channel protein ClC-Ka,2009-07-07 21:55:15 UTC,2009-08-13 06:39:47 UTC,P51800,"Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms","",">Chloride channel protein ClC-Ka MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLMALVSYAMNFA IGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLD IKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVA TVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLP EIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLAS RLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP MPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTALLAFE LTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAK DTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAEPPSRAPGHQQCLQDILARGCPTEP VTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTNPPAPK",CLCNKA,Chloride channel Ka; ClC-K1,687,75286,7.76,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00571:CBS PF00654:Voltage_CLC",HGNC:2026,Membrane,,"","",None,"52-72 161-181 202-222 236-256 282-302 329-349 396-416 417-437 452-472 486-506",Non Essential,"",CLCNKA,CLCNKA,U93878,"","" 819,Chloride channel protein ClC-Kb,2009-07-07 21:55:15 UTC,2009-08-13 06:39:52 UTC,P51801,"Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms","",">Chloride channel protein ClC-Kb MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLA VESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLD IKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVA TVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLP EIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLAS RLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP MPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLAFE VTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAK DTPLEEVVKVVTSTDVAEYPLVESTESQILVGIVRRAQLVQALKAEPPSWAPGHQQCLQDILAAGCPTEP VTLKLSPETSLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMKKAISNLTNPPAPK",CLCNKB,Chloride channel Kb; ClC-K2,687,75418,7.75,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00571:CBS PF00654:Voltage_CLC",HGNC:2027,Membrane,,"","",None,"50-69 91-114 138-159 169-188 200-224 239-257 282-302 325-348 398-417 420-438 466-487 495-514 646-664",Non Essential,"",CLCNKB,CLCNKB,U93879,"","" 820,Chloride intracellular channel protein 1,2009-07-07 21:55:15 UTC,2009-08-13 06:39:39 UTC,O00299,Seems to act as a chloride ion channel,"",">Chloride intracellular channel protein 1 MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYG TEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVL DNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYL SNAYAREEFASTCPDDEEIELAYEQVAKALK",CLIC1,Nuclear chloride ion channel 27; NCC27; Chloride channel ABP; Regulatory nuclear chloride ion channel protein; hRNCC,241,26923,4.82,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane","","",HGNC:2062,Nucleus. Nucleus membrane. Cytoplasm. Cell membrane,,"","",None,None,Non Essential,1RK4,CLIC1,CLIC1,X87689,"","" 821,Chloride intracellular channel protein 2,2009-07-07 21:55:16 UTC,2009-08-13 06:39:44 UTC,O15247,Possible chloride ion channel,"",">Chloride intracellular channel protein 2 MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNP PFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLL KEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFS GVWRYLHNAYAREEFTHTCPEDKEIENTYANVAKQKS",CLIC2,XAP121,247,28357,5.26,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane","","",HGNC:2063,"",,"","",None,None,Non Essential,"",CLIC2,CLIC2,BC022305,"","" 822,Chloride intracellular channel protein 3,2009-07-07 21:55:16 UTC,2009-08-13 06:39:41 UTC,O95833,Stimulates chloride conductance when expressed in cells. Mediates chloride ion transport across the membrane. It may be a component or a regulator of the chloride channel. It may participate in cellular growth control,"",">Chloride intracellular channel protein 3 MAETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGSQLPILLYDSD AKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPVPAQDEALYQQLLRALARLDS YLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAM QEKEFKYTCPHSAEILAAYRPAVHPR",CLIC3,"",236,26649,6.40,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane","","",HGNC:2064,Nucleus. Cytoplasm,,"","",None,None,Non Essential,"",CLIC3,CLIC3,AF102166,"","" 823,Chloride intracellular channel protein 4,2009-07-07 21:55:16 UTC,2009-08-13 06:39:40 UTC,Q9Y696,Chloride channel or a regulator or accessory subunit of other proteins that could provide the pore-froming function,"",">Chloride intracellular channel protein 4 MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLA PGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEAL ERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDI PKEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK",CLIC4,Intracellular chloride ion channel protein p64H1,253,28772,5.26,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane","Posttranslational modification, protein turnover, chaperones","",HGNC:13518,Cytoplasmic vesicle,,"","",None,None,Non Essential,"",CLIC4,CLIC4,BC012444,"","" 824,Chloride intracellular channel protein 5,2009-07-07 21:55:16 UTC,2009-08-13 06:39:58 UTC,Q9NZA1,Possible chloride ion channel,"",">Chloride intracellular channel protein 5 MNDEDYSTIYDTIQNERTYEVPDQPEENESPHYDDVHEYLRPENDLYATQLNTHEYDFVSVYTIKGEETS LASVQSEDRGYLLPDEIYSELQEAHPGEPQEDRGISMEGLYSSTQDQQLCAAELQENGSVMKEDLPSPSS FTIQHSKAFSTTKYSCYSDAEGLEEKEGAHMNPEIYLFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNV TTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPKLAAKHRESNTAGIDIFSK FSAYIKNTKQQNNAALERGLTKALKKLDDYLNTPLPEEIDANTCGEDKGSRRKFLDGDELTLADCNLLPK LHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS",CLIC5,"",410,46503,4.44,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane","Posttranslational modification, protein turnover, chaperones","",HGNC:13517,Isoform 2:Golgi apparatus. Centrosome,,"","",None,None,Non Essential,"",CLIC5,CLIC5,BC035968,"","" 825,Chloride intracellular channel protein 6,2009-07-07 21:55:16 UTC,2009-08-13 06:39:39 UTC,Q96NY7,"Probable chloride ion channel. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity)","",">Chloride intracellular channel protein 6 MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPE AEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEE AEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNI QAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSM DAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDA RADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEE GPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYDGESIGNCPFS QRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLAPPRYPKLG TQHPESNSAGNDVFAKFSAFIKNTKKDANEIHEKNLLKALRKLDNYLNSPLPDEIDAYSTEDVTVSGRKF LDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVA KRMK",CLIC6,"",704,73012,4.01,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane","Translation, ribosomal structure and biogenesis","",HGNC:2065,Cytoplasm (By similarity). Cell membrane (By similarity),,"","",None,None,Non Essential,"",CLIC6,CLIC6,BC040196,"","" 826,"Chloride channel protein, skeletal muscle",2009-07-07 21:55:16 UTC,2009-08-13 06:39:27 UTC,P35523,"Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport","",">Chloride channel protein, skeletal muscle MEQSRSQQRGGEQSWWGSDPQYQYMPFEHCTSYGLPSENGGLQHRLRKDAGPRHNVHPTQIYGHHKEQFS DREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDWIFLVLLGLLMALVSWSMDYVSA KSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMK AFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFG TPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPA FAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMP REAISTLFDNNTWVKHAGDPESLGQSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVL GAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMM VAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQ TTTVKTLPLVDSKDSMILLGSVERSELQALLQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGLPGA PPGRPESFAFVDEDEDEDLSGKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPAGQRPSIFQS LLHCLLGRARPTKKKTTQDSTDLVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTL FSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSTRKSTGAPPSSAENWNLP EDRPGATGTGDVIAASPETPVPSPSPEPPLSLAPGKVEGELEELELVESPGLEEELADILQGPSLRSTDE EDEDELIL",CLCN1,Chloride channel protein 1; ClC-1,988,108757,5.92,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00571:CBS PF00654:Voltage_CLC",HGNC:2019,Membrane,,"","",None,"118-137 159-182 206-227 235-254 266-290 305-323 348-368 391-414 456-475 478-496 524-545 553-572 839-857",Non Essential,"",CLCN1,CLCN1,Z25768,"","" 827,Chloride channel protein 2,2009-07-07 21:55:16 UTC,2009-08-13 06:39:33 UTC,P51788,"Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport","",">Chloride channel protein 2 MAAAAAEEGMEPRALQHEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPELLEYGRSRCA RCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTY PVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVH IASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFF AATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMR KQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPST SQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSS TYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIK KLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERS QVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPSPEASVCFQVNTEDSAFPAARGETHKPLKPALK RGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEE ILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIE GSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ",CLCN2,ClC-2,898,98497,8.47,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00571:CBS PF00654:Voltage_CLC",HGNC:2020,Membrane,,"","",None,"91-110 132-155 179-200 208-227 239-263 278-296 321-341 364-387 431-450 453-471 499-520 528-547 808-826",Non Essential,"",CLCN2,CLCN2,BC021578,"","" 828,Chloride channel protein 3,2009-07-07 21:55:17 UTC,2009-08-13 06:39:36 UTC,P51790,"Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short- term memory","",">Chloride channel protein 3 MTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSG WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELII GQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT LVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLE EVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFI RANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDM NASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQL AYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSK WVGDAFGREGIYEAHIRLNGYPFLDAKEEFEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINE TSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILD MSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN",CLCN3,ClC-3,762,84794,7.12,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00571:CBS PF00654:Voltage_CLC",HGNC:2021,Isoform 3:Membrane,,"","",None,"68-88 154-174 175-195 202-222 259-279 285-305 330-350 365-385 442-462 467-487 508-528 536-556",Non Essential,"",CLCN3,CLCN3,AB019542,"","" 830,Chloride channel protein 5,2009-07-07 21:55:17 UTC,2009-08-13 06:39:47 UTC,P51795,"Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May play an important role in renal tubular function","",">Chloride channel protein 5 MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGS LAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNY FMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGK EGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR SFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTT QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPA GVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWC SQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDA HIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQR LVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVV DIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN",CLCN5,ClC-5,746,83148,6.81,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00571:CBS PF00654:Voltage_CLC",HGNC:2023,Golgi apparatus membrane,,"","",None,"55-75 133-153 189-209 246-266 317-337 352-372 428-448 453-473 494-514 521-541",Non Essential,"",CLCN5,CLCN5,X81836,"","" 831,Chloride transport protein 6,2009-07-07 21:55:17 UTC,2009-08-13 06:39:54 UTC,P51797,"Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport","",">Chloride channel protein 6 MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDN KKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTF VFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVV GAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKV LFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGAT FNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTED VNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFV PSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVT LMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVH HAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPA EKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQP RLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNA VGEIVGIITRHNLTYEFLQARLRQHYQTI",CLCN6,ClC-6,869,97218,6.90,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00571:CBS PF00654:Voltage_CLC",HGNC:2024,Membrane,,"","",None,"82-102 130-150 184-204 245-265 334-354 375-395 462-482 511-531",Non Essential,"",CLCN6,CLCN6,BC117424,"","" 832,Chloride channel protein 7,2009-07-07 21:55:17 UTC,2009-08-13 06:39:37 UTC,P51798,"Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport","",">Chloride channel protein 7 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLD PDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLV ACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFR RDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMW DLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTL GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIV RMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREV MSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLG LVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLV VVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT",CLCN7,ClC-7,805,88680,8.57,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00571:CBS PF00654:Voltage_CLC",HGNC:2025,Membrane,,"","",None,"128-148 177-197 224-244 292-312 327-347 375-395 412-432 495-515 518-538 549-569 581-601",Non Essential,"",CLCN7,CLCN7,U88844,"","" 833,Ryanodine receptor 1 ,2009-07-07 21:55:19 UTC,2009-08-13 06:40:00 UTC,P21817,Communication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules,"",">Ryanodine receptor 1 MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAICCFVLEQ SLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDA TGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSRCEE GFVTGGHVLRLFHGHMDECLTISPADSDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLR VRHVTTGQYLALTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHV ASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEGMLSMVLNCI DRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGIL EVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGREL LLQTNLINYVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEG WGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESF NLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVDFH SLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQ TTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGY NIEPPDQEPSQVENQSRCDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELA YVFNGHRGQRWHLGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPV CSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAEDEARAAEPDPD YENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATTEKNKKRGFLFKAKKVAMMTQ PPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRV VTVTMGDEQGNVHSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQ VEPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNH FLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPG RSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVR DGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEE EKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAA FAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQD LLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQM GPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFC RISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSC PMLVAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAI EEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEA LRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLS RGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTG WANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVD AEGNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEK DKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRE LQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYF TNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTV MKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQH QFGDDVILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYT TKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPE APPSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNRAQWLTEPNPS AEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAKAGDIQSGGSDQERTKKKRRG DRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLR WQMALYRGVPGREEDADDPEKIVRRVQEVSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTP LYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTAL TEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQN KAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVD YLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVG FLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKF FDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANR FQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETDEDEGAGAAEA GAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAV TRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDADGEGASE GAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGV DGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRV KFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYIT EQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEITAHNERKPN PPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSS VTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGD EIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFD TTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS",RYR1,RYR-1; RyR1; Skeletal muscle-type ryanodine receptor; Skeletal muscle calcium release channel,5038,565182,4.96,">>> Function: ligand-gated ion channel activity Function: intracellular ligand-gated ion channel activity Function: intracellular ligand-gated calcium channel activity Function: ryanodine-sensitive calcium-release channel activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: calcium channel activity || >>> Process: homeostasis Process: cell homeostasis Process: cell ion homeostasis Process: cation homeostasis Process: metal ion homeostasis Process: calcium ion homeostasis Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","Translation, ribosomal structure and biogenesis","PF08709:Ins145_P3_rec PF00520:Ion_trans PF02815:MIR PF08454:RIH_assoc PF06459:RR_TM4-6 PF01365:RYDR_ITPR PF02026:RyR PF00622:SPRY",HGNC:10483,Membrane,,"","",None,"3124-3144 3188-3206 3984-4003 4022-4040 4278-4301 4343-4363 4560-4581 4649-4672 4790-4810 4838-4857 4880-4899 4924-4938",Non Essential,"",RYR1,RYR1,S77392,"","" 834,Ryanodine receptor 2,2009-07-07 21:55:19 UTC,2009-08-13 06:39:27 UTC,Q92736,Communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T- tubules (By similarity),"",">Ryanodine receptor 2 MGARAKTRSSSCELMMKWFCSAPQPSTKNNRSYAWQQKDLATDFVSWSPLPIPRMCPQTSPSAPLCWSSP SLSGRCRRCWLTPWRNQKGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDK LAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLW SVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRV AWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTS EIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRST VFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEE GMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRL ERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLI CDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEG YSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRING QPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQ ERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNK RQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLPKNYQLTSGYKPAPMD LSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLRE AVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGC QPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAF KDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVP SNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGGLPGAGLFGPKN DLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHS ARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDE KGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPA VFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRIS ERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDE PQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFPDENKKHGLPGIG LSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLI KLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVDDAKLQGAGEEEAKGGKRPKEG LLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKT KEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSL VEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRAL PKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVM EVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDV AAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGES VEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTI HMGNAIMTFYSALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVV EPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCT AVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRL VFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELF KLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKW SMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYN RTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLV PYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILE FDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLG VLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTH TRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQR SALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELA ESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDE GAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFTTL ARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLI TDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTE DEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDDTSDPEKTVERVLDIANVLFHLEQKSKRVGRRH YCLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIE DLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVK SFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLK EKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNS DFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTE YIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVN GTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSE TEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPF LGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQL AAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLSLKSLKKQMKKVK KMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEV RGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPM PEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWK KIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSH RIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPS EDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDS SLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTH NGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIE DPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVP HGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN",RYR2,RYR-2; RyR2; hRYR-2; Cardiac muscle-type ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel,4965,564749,6.20,">>> Function: ligand-gated ion channel activity Function: intracellular ligand-gated ion channel activity Function: intracellular ligand-gated calcium channel activity Function: ryanodine-sensitive calcium-release channel activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: calcium channel activity || >>> Process: homeostasis Process: cell homeostasis Process: cell ion homeostasis Process: cation homeostasis Process: metal ion homeostasis Process: calcium ion homeostasis Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00036:efhand PF08709:Ins145_P3_rec PF00520:Ion_trans PF02815:MIR PF08454:RIH_assoc PF06459:RR_TM4-6 PF01365:RYDR_ITPR PF02026:RyR PF00622:SPRY",HGNC:10484,Membrane,,"","",None,"3088-3107 3151-3169 3938-3957 3976-3993 4231-4254 4292-4312 4498-4518 4576-4598 4718-4738 4766-4784 4808-4825 4843-4865",Non Essential,"",RYR2,RYR2,AJ002511,"","" 835,Ryanodine receptor 3,2009-07-07 21:55:20 UTC,2009-08-13 06:39:47 UTC,Q15413,Communication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules (By similarity),"",">Ryanodine receptor 3 MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDLCVCNFVL EQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYLTCLTTSRSQTDKLAFDVGLR EHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSG SSIEEGYLLGGHVVRLFHGHDECLTIPSTDQNDSQHRRIFYEAGGAGTRASSLWRVEPLRISWSGSNIRW GQAFRLRHLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGD SVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLNCID RLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILE VLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDILCSLCLCNGVAVRANQNLICDNLLPRRNLL LQTRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPCPGGGEGW GGNGVGDDLYSYGFDGLHLWSGRIPRAVASVNQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFN TDGLFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGIRDLLGT TQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPCLVEFSK LPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQE ILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYN IEPSDQELADSAVEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQA FVFEGNRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPI CCLGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEILSHTTTQCYY AIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVASSQ RSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPL SAAIFRSEEKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEEN RCVDILELCEQEDLMRFHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLL ISIHLASAKERKLMMKNEYIIPITSTTRNICLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEDHQ KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDDDDVRQILLLI DPSVFGEHSAGTEEGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQ HRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTKEFRSPPQEQINMLLNFQLGENCPCPE EIREELYDFHEDLLLHCGVPLEEEEEEEEDTSWTGKLCALVYKIKGPPKPEKEQPTEEEERCPTTLKELI SQTMICWAQEDQIQDSELVRMMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTINLLAALGQIRSLLSV RMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLEKVVTYLAGCG LQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGL LAAMQGAIKISENPALDLPSQGYKREVSTEDDEEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGK GEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTF LLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIY RLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQI SVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPFKTL TEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQANQGNSYSPAPLDLSNVVLSR ELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGIIVSR GMKDMELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQY FTSHCLYFLSSPLKPLSSSGYASHKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVTQ HQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVF NTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGP ENLPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLE KLKKKAVKTVQEEEQLKADGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQ LFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKSDDPAVKWQLN LYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLP RHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEETEKQPDPLHQIILYFSRNALTERSK LEDDPLYTSYSSMMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGE MSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMV TEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANM QMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLK DLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYVDFVDRFHEPAKDI GFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQ VKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEE EEDGSLEPASAFAMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLF TILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGITTELVHFIKG EKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQKKRKAQAAEMKAANEAEGKV ESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQKVEKPEAFTANFFKGLEIYQTKLLHYLARNF YNLRFLALFVAFAINFILLFYKVTEEPLEEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRAL AIIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYW DKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDN SFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFN FFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLIN KDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG",RYR3,RYR-3; RyR3; Brain-type ryanodine receptor; Brain ryanodine receptor-calcium release channel,4870,551938,5.38,">>> Function: ligand-gated ion channel activity Function: intracellular ligand-gated ion channel activity Function: intracellular ligand-gated calcium channel activity Function: ryanodine-sensitive calcium-release channel activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: cation channel activity Function: calcium channel activity || >>> Process: homeostasis Process: cell homeostasis Process: cell ion homeostasis Process: cation homeostasis Process: metal ion homeostasis Process: calcium ion homeostasis Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00036:efhand PF08709:Ins145_P3_rec PF00520:Ion_trans PF02815:MIR PF08454:RIH_assoc PF06459:RR_TM4-6 PF01365:RYDR_ITPR PF02026:RyR PF00622:SPRY",HGNC:10485,Membrane,,"","",None,"2985-3005 3049-3067 3836-3855 3874-3892 4132-4153 4195-4215 4410-4431 4482-4505 4622-4642 4670-4689 4712-4731 4756-4770",Non Essential,"",RYR3,RYR3,X74270,"","" 847,Integrin alpha-V ,2009-07-07 21:55:46 UTC,2009-08-13 06:39:40 UTC,P06756,"The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions","",">Integrin alpha-V MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGA PKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAP LYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQ GQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTL GMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQ RASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQI LEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKT CSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRG GLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDN VCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAF KTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLA AVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLY ILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCL KIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTN VTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET",ITGAV,Vitronectin receptor subunit alpha; CD51 antigen; Contains: RecName: Integrin alpha-V heavy chain; Contains: RecName: Integrin alpha-V light chain,1048,116039,5.36,"","","PF01839:FG-GAP PF00357:Integrin_alpha PF08441:Integrin_alpha2",HGNC:6150,Membrane,,"","",1-30,993-1016,Non Essential,1M1X,ITGAV,ITGAV,U07375,"","" 848,Integrin beta-3,2009-07-07 21:55:47 UTC,2009-08-13 06:39:32 UTC,P05106,"Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions","",">Integrin beta-3 MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENL LKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDI YYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTC LPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKT HIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSEL IPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDT VSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGP GWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGE MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTC PDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSS GKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANN PLYKEATSTFTNITYRGT",ITGB3,Platelet membrane glycoprotein IIIa; GPIIIa; CD61 antigen,788,87058,4.85,">>> Function: Not Available || >>> Process: development Process: cell-substrate adhesion Process: cell-matrix adhesion Process: cellular process Process: cell adhesion || >>> Component: protein complex Component: receptor complex Component: integrin complex","","PF07974:EGF_2 PF08725:Integrin_b_cyt PF07965:Integrin_B_tail PF00362:Integrin_beta",HGNC:6156,Membrane,,REACT_604-Hemostasis;,"",1-26,719-741,Non Essential,1M1X,ITGB3,ITGB3,M25108,"","" 858,Platelet glycoprotein VI,2009-07-07 21:55:49 UTC,2009-08-13 06:39:50 UTC,Q9HCN6,"Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2","",">Platelet glycoprotein VI MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLEKLSSSRYQDQ AVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGF DQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPS RLPTEPPSSVAEFSEATAELTVSFTNKVFTTETSRSITTSPKESDSPAGPARQYYTKGNLVRICLGAVIL IILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPQTRKSHGGQDGGRQDVHSRGLCS",GP6,"",339,36923,9.69,"","",PF00047:ig,HGNC:14388,Membrane,,"","",1-20,268-288,Non Essential,"",GP6,GP6,BC111963,"","" 859,Integrin alpha-IIb,2009-07-07 21:55:55 UTC,2009-08-13 06:39:32 UTC,P08514,"Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface","",">Integrin alpha-IIb MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGA PRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAP WQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAG ELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLN TTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRAEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRAD RKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQV LVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQ LLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQA GTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIV LDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGF ERLICNQKKENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLD VPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQP SDLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPVLVS CDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEA QVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE",ITGA2B,"Platelet membrane glycoprotein IIb; GPalpha IIb; GPIIb; CD41 antigen; Contains: RecName: Integrin alpha-IIb heavy chain; Contains: RecName: Integrin alpha-IIb light chain, form 1; Contains: RecName: Integrin alpha-IIb light chain, form 2",1039,113392,5.03,">>> Function: Not Available || >>> Process: cell-substrate adhesion Process: cell-matrix adhesion Process: cellular process Process: cell adhesion || >>> Component: protein complex Component: receptor complex Component: integrin complex","","PF01839:FG-GAP PF00357:Integrin_alpha PF08441:Integrin_alpha2",HGNC:6138,Membrane,,REACT_604-Hemostasis;,"",1-31,994-1019,Non Essential,1TYE,ITGA2B,ITGA2B,AF098114,"","" 860,Cyclic nucleotide-gated olfactory channel,2009-07-07 21:55:57 UTC,2009-08-13 06:39:40 UTC,Q16280,Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons,"",">Cyclic nucleotide-gated olfactory channel MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIV RLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWY YCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKK LRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVL YILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEY LFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKE MYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAV TEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLK QRITVLETKMKQNNEDDYLSDGMNSPELAAADEP",CNGA2,Cyclic nucleotide-gated cation channel 2; CNG channel alpha-2; CNG-2; CNG2,664,76049,6.14,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF00027:cNMP_binding PF00520:Ion_trans",HGNC:2149,Membrane,,"","",None,"139-159 172-192 225-245 275-295 351-371 454-474",Non Essential,"",CNGA2,CNGA2,S76067,"","" 951,Chloride channel protein 4,2009-07-08 17:59:14 UTC,2009-08-13 06:39:31 UTC,P51793,"Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport","",">Chloride channel protein 4 MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIKSLLDAWSG WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLV NQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVT LVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLE EVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFI RCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQL AYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSK WVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETD YNGFPVVVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLS PFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN",CLCN4,ClC-4,760,84918,6.86,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: voltage-gated ion channel activity Function: voltage-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00571:CBS PF00654:Voltage_CLC",HGNC:2022,Membrane,,"","",None,"68-88 148-168 202-222 259-279 330-350 365-385 442-462 467-487 508-528 535-555",Non Essential,"",CLCN4,CLCN4,AF170492,"","" 952,cGMP-gated cation channel alpha-1,2009-07-08 17:59:50 UTC,2009-08-13 06:39:42 UTC,P29973,Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors,"",">cGMP-gated cation channel alpha-1 MKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKG GPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKS KDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLID MFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEF FQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLY WSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFR NVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLK LQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTAN IKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSV DLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST",CNGA1,"CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel alpha-1; Cyclic nucleotide-gated channel, photoreceptor; Cyclic nucleotide-gated cation channel 1; Rod photoreceptor cGMP-gated channel subunit alpha",686,79127,7.70,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","Translation, ribosomal structure and biogenesis","PF00027:cNMP_binding PF00520:Ion_trans",HGNC:2148,Membrane,,"","",None,"161-181 195-213 238-257 296-318 371-390 475-495",Non Essential,"",CNGA1,CNGA1,S76062,"","" 953,5-hydroxytryptamine 1A receptor,2009-07-09 19:56:52 UTC,2009-08-13 06:39:40 UTC,P08908,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity","",">5-hydroxytryptamine receptor 1A MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNV ANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITD PIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLL MLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGA VRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGII MGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC RQ",HTR1A,5-HT-1A; 5-HT1A; Serotonin receptor 1A; G-21,422,46107,9.05,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5286,Cell membrane,,"","",None,"37-62 74-98 110-132 153-178 192-217 346-367 379-403",Non Essential,"",HTR1A,HTR1A,Z11168,"","" 954,Epoxide hydrolase 1,2009-07-13 21:49:40 UTC,2009-08-13 06:39:37 UTC,P07099,Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water,"",">Epoxide hydrolase 1 MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKF RFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHT PKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYK LMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVE LLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFS LDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ",EPHX1,Microsomal epoxide hydrolase; Epoxide hydratase,455,52949,7.28,">>> Function: hydrolase activity Function: hydrolase activity, acting on ether bonds Function: ether hydrolase activity Function: leukotriene-A4 hydrolase activity Function: epoxide hydrolase activity Function: catalytic activity || >>> Process: response to stimulus Process: response to abiotic stimulus Process: response to chemical stimulus Process: response to toxin || >>> Component: membrane Component: cell Component: cell fraction Component: membrane fraction Component: vesicular fraction Component: microsome","","PF00561:Abhydrolase_1 PF06441:EHN",HGNC:3401,Microsome membrane,,"","",None,2-20,Non Essential,"",EPHX1,EPHX1,AF276638,"","" 955,Cytochrome P450 2C18,2009-07-16 20:41:40 UTC,2009-08-13 06:39:43 UTC,P33260,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics","",">Cytochrome P450 2C18 MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFG LKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRS IEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSS PWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQS EFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDA VVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV",CYP2C18,CYPIIC18; P450-6B/29C,490,55711,7.22,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2620,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP2C18,CYP2C18,BC096258,"","" 956,DNA gyrase subunit A,2009-07-19 19:05:08 UTC,2009-08-13 06:39:45 UTC,P43700,"DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings","",">DNA gyrase subunit A MTDSIQSSITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDREGNTANKKYVKSARV VGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQALLTDLD KETVNFSPNYDGELMIPDVLPTRIPALLANGSSGIAVGMATNIPPHNLNEVLNGCLAYIDKNEITIDELM QHIPGPDFPTAALINGRKGIEEAYRTGRGKVYVRARATVETNEKGREQIIVSELPYQVNKAKLVEKIAEL IREKKIEGISNITDLSNKEGIRIEIDIKRDAVGEVVLNHLYSLTQMQVTFGINMVALDHGQPRLFNLKEI IEAFVLHRREVVTRRSIFELRKARERTHILEGLAVARSNIDEMIAIIRNSKNREEAATSISSRSWTLHSD IINLLDASARPDELEENLGIQGEQYYLSPAQVNAILELRLHRLTGIAFEEVIKEYEELLVKIADLLHILS SAERLMEVIREELEEVKAQFGDDRLTEITAASGDIDLEDLIAQEDVVVTLSHEGYVKYQPLTDYEAQRRG GKGKSATKMKEEDFIEKLLVANTHDTILCFSSRGRLYWLKVYQLPQASRGARGRPIVNILPLQENERITA ILPVSAYEEDKFVVMATAGGIVKKIALTEFSRPRSNGIIALNLRDEDELIGVDITDGSNEIMLFSSQGRV VRFAENAVRAMGRLATGVRGIKLALTNDISDDESAVEIEDISDDNAEASLDLNIDKVVSLVVPKGEGAIL TATQNGYGKRTQLSEYPTKSRNTKGVISIKVSERNGKVVAATQVEETDQIMLITDAGTLVRTRVSEVSIV GRNTQGVRLIRTADDEHVVSLERVCDADEDDSLEESSSEE",gyrA,"",880,97820,4.85,">>> Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: DNA topoisomerase activity Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: DNA replication Process: DNA-dependent DNA replication Process: DNA unwinding during replication Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA topological change || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: chromosome","Replication, recombination and repair","PF03989:DNA_gyraseA_C PF00521:DNA_topoisoIV","",Cytoplasmic,,"","",None,None,Essential,"",gyrA,"",L42023,"","" 957,DNA topoisomerase 4 subunit A,2009-07-19 19:05:56 UTC,2009-08-13 06:39:34 UTC,P43702,Topoisomerase IV is essential for chromosome segregation. It has relaxation of supercoiled DNA activity. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity),"",">DNA topoisomerase 4 subunit A MTNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNATAKYKKSART VGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKISEILLNEL GQGTVDYQPNFDGTLAEPQYLPARLPHILLNGTTGIAVGMATDIPPHNINEIADAAVMLLDNPKAGLDDV LEIVQGPDFPTEAEIISPKSEIRKIYEQGRGSIKMRATWKKEDGEIIISALPHQSSPSKVIAQIAEQMTA KKLPMLEDIRDEADHENPIRIVLVPRSNRVDTDALMAHLFATTDLEKSYRVNMNMIGLDHKPAVKGLLEI LNEWLDFRRTTVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHEDDPKAELMARFNLSDEQADA ILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYANPRMSQLVEREEA KMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHACGKSNQAVVFIDSTGRSYALD PLSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLMASDAGYGFICKFEDLIARNKAGKALISLPE NAKVLKPKTLINSTALVVAITSAGRMLIFPAQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQA SLEFYSGKRKIVLKPEDLQKFRAERGRKGSTLPRGLHTNLEIMVIEP",parC,Topoisomerase IV subunit A,747,83368,6.42,">>> Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: DNA topoisomerase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: DNA replication Process: DNA-dependent DNA replication Process: DNA unwinding during replication Process: DNA topological change Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: chromosome","Replication, recombination and repair","PF03989:DNA_gyraseA_C PF00521:DNA_topoisoIV","",Cell membrane,,"","",None,None,Essential,"",parC,"",L42023,"","" 958,Cytochrome P450 2C8,2009-07-20 15:51:55 UTC,2009-08-13 06:39:28 UTC,P10632,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol)","",">Cytochrome P450 2C8 MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFG MNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRS IEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNS PWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKS EFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDA VVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV",CYP2C8,CYPIIC8; P450 form 1; P450 MP-12/MP-20; P450 IIC2; S-mephenytoin 4-hydroxylase,490,55825,8.62,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2622,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,1PQ2,CYP2C8,CYP2C8,Y00498,"","" 959,Kappa-type opioid receptor,2009-07-20 16:32:42 UTC,2009-08-13 06:39:50 UTC,P41145,Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions,"",">Kappa-type opioid receptor MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVF VVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYY NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIEC SLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVV AVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKM RMERQSTSRVRNTVQDPAYLRDIDGMNKPV",OPRK1,KOR-1,380,42646,7.79,">>> Function: peptide receptor activity, G-protein coupled Function: opioid receptor activity Function: kappa-opioid receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:8154,Cell membrane,,"","",None,"59-85 96-117 133-154 174-196 223-247 276-299 312-333",Non Essential,"",OPRK1,OPRK1,U16860,"","" 960,Growth hormone-releasing hormone receptor,2009-07-22 22:34:47 UTC,2009-08-13 06:39:27 UTC,Q02643,"Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion","",">Growth hormone-releasing hormone receptor MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGS GEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELLAEEESYFSTVKIIYTVGHSIS IVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASH FATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSP YWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPD NAGLGIRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLT SMC",GHRHR,GHRH receptor; GRF receptor; GRFR,423,47402,6.73,">>> Function: secretin-like receptor activity Function: vasoactive intestinal polypeptide receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane","","PF00002:7tm_2 PF02793:HRM",HGNC:4266,Cell membrane,,"","",1-22,"133-152 163-181 205-227 241-262 281-304 330-348 362-381",Non Essential,"",GHRHR,GHRHR,U42225,"","" 961,Lutropin-choriogonadotropic hormone receptor,2009-07-22 22:34:47 UTC,2009-08-13 06:39:52 UTC,P22888,Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase,"",">Lutropin-choriogonadotropic hormone receptor MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFR GLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPD VTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHL EKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCC AFRNLPTKEQNFSHSISENFSKQCESTVRKVSNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAF NPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDS QTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGG WLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMA TNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTF QRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC",LHCGR,LH/CG-R; LSH-R; Luteinizing hormone receptor; LHR,699,78617,8.58,">>> Function: lutropin-choriogonadotropic hormone receptor activity Function: protein-hormone receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:6585,Cell membrane,,"","",1-26,"364-385 396-416 440-462 483-505 526-549 571-594 606-627",Non Essential,"",LHCGR,LHCGR,AF024642,"","" 962,Gonadotropin-releasing hormone receptor,2009-07-22 22:34:47 UTC,2009-08-13 06:39:50 UTC,P30968,Receptor for gonadotropin releasing hormone (GnRH) that mediate the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act a an inhibitor of GnRH-R signaling,"",">Gonadotropin-releasing hormone receptor MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKG KKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRS LAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAF YNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCW TPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL",GNRHR,GnRH receptor; GnRH-R,328,37731,9.93,">>> Function: protein-hormone receptor activity Function: gonadotropin-releasing hormone receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:4421,Cell membrane,,"","",None,"39-58 78-97 116-137 165-184 213-232 282-300 307-326",Non Essential,"",GNRHR,GNRHR,Z99995,"","" 963,Growth hormone receptor,2009-07-22 22:34:48 UTC,2009-08-13 06:39:36 UTC,P10912,Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling,"",">Growth hormone receptor MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTD EVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKC FSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPI LTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTV MLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDI DEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGE ADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQV SDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSL NQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVST DQLNKIMP",GHR,GH receptor; Somatotropin receptor; Contains: RecName: Growth hormone-binding protein; GH-binding protein; GHBP; Serum-binding protein,638,71500,4.51,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","",PF00041:fn3,HGNC:4263,Growth hormone-binding protein:Secreted,,"","",1-18,265-288,Non Essential,1KF9,GHR,GHR,AJ278681,"","" 964,Prolactin receptor,2009-07-22 22:34:48 UTC,2009-08-13 06:39:42 UTC,P16471,This is a receptor for the anterior pituitary hormone prolactin. Isoforms 4 and 6 are unable to transduce prolactin signaling,"",">Prolactin receptor MKENVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGET LMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQP EDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKP DHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKIKGFD AHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSG RGSCDSPSLLSEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQ PSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVESFHSETDQDT PWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKVSGVMDNNILVL VPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSSKCRLQLGGLDYLDPACFTHSFH",PRLR,PRL-R,622,69506,5.08,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","",PF00041:fn3,HGNC:9446,Membrane,,"","",1-24,235-258,Non Essential,1BP3,PRLR,PRLR,S78505,"","" 965,Somatostatin receptor type 1,2009-07-22 22:34:48 UTC,2009-08-13 06:39:58 UTC,P30872,Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins,"",">Somatostatin receptor type 1 MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCL VGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVN MFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNM LMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVF VICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEP VDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL",SSTR1,SS1R; SRIF-2,391,42687,8.40,">>> Function: peptide receptor activity, G-protein coupled Function: neuropeptide receptor activity Function: somatostatin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:11330,Cell membrane,,"","",None,"57-84 95-120 132-153 176-196 220-244 271-296 304-327",Non Essential,"",SSTR1,SSTR1,BC035618,"","" 966,Somatostatin receptor type 5,2009-07-22 22:34:48 UTC,2009-08-13 06:39:29 UTC,P35346,Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase,"",">Somatostatin receptor type 5 MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAK MKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLA VVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGF FAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEP ASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPA HRAAANGLMQTSKL",SSTR5,SS5R,364,39203,9.72,">>> Function: peptide receptor activity, G-protein coupled Function: neuropeptide receptor activity Function: somatostatin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:11334,Cell membrane,,"","",None,"39-66 77-101 114-135 158-178 198-222 248-273 284-308",Non Essential,"",SSTR5,SSTR5,AE006466,"","" 967,Substance-K receptor,2009-07-22 22:34:48 UTC,2009-08-13 06:39:42 UTC,P21452,This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system,"",">Substance-K receptor MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNY FIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQ PRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPL AVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIY CHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNR CHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI",TACR2,SKR; Neurokinin A receptor; NK-2 receptor; NK-2R; Tachykinin receptor 2,398,44440,8.74,">>> Function: peptide receptor activity, G-protein coupled Function: neuropeptide receptor activity Function: tachykinin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: plasma membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:11527,Cell membrane,,"","",None,"33-56 70-90 108-129 150-170 197-218 252-272 291-310",Non Essential,"",TACR2,TACR2,AY322545,"","" 968,"Alanine--glyoxylate aminotransferase 2, mitochondrial",2009-07-22 22:34:49 UTC,2009-08-13 06:39:55 UTC,Q9BYV1,L-alanine + glyoxylate = pyruvate + glycine,"",">Alanine--glyoxylate aminotransferase 2, mitochondrial MTLIWRHLLRPLCLVTSAPRILEMHPFLSLGTSRTSVTKLSLHTKPRMPPCDFMPERYQSLGYNRVLEIH KEHLSPVVTAYFQKPLLLHQGHMEWLFDAEGSRYLDFFSGIVTVSVGHCHPKVNAVAQKQLGRLWHTSTV FFHPPMHEYAEKLAALLPEPLKVIFLVNSGSEANELAMLMARAHSNNIDIISFRGAYHGCSPYTLGLTNV GTYKMELPGGTGCQPTMCPDVFRGPWGGSHCRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAKS IAGFFAEPIQGVNGVVQYPKGFLKEAFELVRARGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAK GIGNGFPMAAVITTPEIAKSLAKCLQHFNTFGGNPMACAIGSAVLEVIKEENLQENSQEVGTYMLLKFAK LRDEFEIVGDVRGKGLMIGIEMVQDKISCRPLPREEVNQIHEDCKHMGLLVGRGSIFSQTFRIAPSMCIT KPEVDFAVEVFRSALTQHMERRAK",AGXT2,AGT 2; (R)-3-amino-2-methylpropionate--pyruvate transaminase; Beta-alanine-pyruvate aminotransferase; Beta-ALAAT II; D-AIBAT,514,57157,7.91,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: Not Available || >>> Component: Not Available",Amino acid transport and metabolism,PF00202:Aminotran_3,HGNC:14412,Mitochondrion (Potential),,"","",None,None,Non Essential,"",AGXT2,AGXT2,AK223375,"","" 969,Glutamate decarboxylase 1,2009-07-22 22:34:49 UTC,2009-08-13 06:39:49 UTC,Q99259,Catalyzes the production of GABA,"",">Glutamate decarboxylase 1 MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKER QSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLD FHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTAN TNMFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVP KLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVY GAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKE KGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYL YAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQG DKANFFRMVISNPAATQSDIDFLIEEIERLGQDL",GAD1,Glutamate decarboxylase 67 kDa isoform; 67 kDa glutamic acid decarboxylase; GAD-67,594,66897,7.67,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:4092,"",,"","",None,None,Non Essential,"",GAD1,GAD1,M55574,"","" 970,Kynureninase,2009-07-22 22:34:49 UTC,2009-08-13 06:39:37 UTC,Q16719,"Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic (AA) and 3- hydroxyanthranilic acids (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity (By similarity)","",">Kynureninase MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIY FLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVN LHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEK EGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNA GAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFK QATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN",KYNU,L-kynurenine hydrolase,465,52352,7.04,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid carbon-carbon bonds Function: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances Function: kynureninase activity Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: cofactor metabolism Process: coenzyme metabolism Process: coenzyme biosynthesis Process: pyridine nucleotide biosynthesis Process: NAD biosynthesis Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid derivative metabolism Process: biogenic amine metabolism Process: indolalkylamine metabolism Process: tryptophan metabolism Process: tryptophan catabolism Process: physiological process Process: metabolism || >>> Component: cell Component: intracellular Component: cytoplasm",Amino acid transport and metabolism,PF00266:Aminotran_5,HGNC:6469,Cytoplasm,,"","",None,None,Non Essential,"",KYNU,KYNU,U57721,"","" 971,"Serine hydroxymethyltransferase, cytosolic",2009-07-22 22:34:49 UTC,2009-08-13 06:39:46 UTC,P34896,Interconversion of serine and glycine,"",">Serine hydroxymethyltransferase, cytosolic MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLN NKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMG LDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE YARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKT GKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIV TGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF",SHMT1,SHMT; Serine methylase; Glycine hydroxymethyltransferase,483,53083,7.77,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: glycine hydroxymethyltransferase activity || >>> Process: L-serine metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: glycine metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00464:SHMT,HGNC:10850,Cytoplasm,,"","",None,None,Non Essential,1BJ4,SHMT1,SHMT1,BC038598,"","" 972,"Cysteine desulfurase, mitochondrial",2009-07-22 22:34:49 UTC,2009-08-13 06:39:40 UTC,Q9Y697,Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters,"",">Cysteine desulfurase, mitochondrial MLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAPEVGPVLRPLYMDVQATTPLD PRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGATESNNIAIKGVAR FYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMTVNNEIG VKQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEA LQSGGGQERGMRSGTVPTPLVVGLGAACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDPKHHY PGCINLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVD YTVEKCIQHVKRLREMSPLWEMVQDGIDLKSIKWTQH",NFS1,"",457,50196,8.45,">>> Function: transferase activity, transferring sulfur-containing groups Function: sulfurtransferase activity Function: cysteine desulfurase activity Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: sulfur amino acid metabolism Process: cysteine metabolism Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00266:Aminotran_5,HGNC:15910,Mitochondrion. Cytoplasm,,"","",None,None,Non Essential,"",NFS1,NFS1,AJ010952,"","" 973,"Aspartate aminotransferase, cytoplasmic",2009-07-22 22:34:50 UTC,2009-08-13 06:39:27 UTC,P17174,L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate,"",">Aspartate aminotransferase, cytoplasmic MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHE YLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPT WENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIA SVMKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPES ILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGT WNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ",GOT1,Transaminase A; Glutamate oxaloacetate transaminase 1,413,46248,7.01,">>> Function: transaminase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,PF00155:Aminotran_1_2,HGNC:4432,Cytoplasm,,"","",None,None,Non Essential,1AJS,GOT1,GOT1,BC000498,"","" 974,"Ornithine aminotransferase, mitochondrial",2009-07-22 22:34:50 UTC,2009-08-13 06:39:43 UTC,P04181,L-ornithine + a 2-oxo acid = L-glutamate 5- semialdehyde + an L-amino acid,"",">Ornithine aminotransferase, mitochondrial MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYL WDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMN TGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYN DLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDY ENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENAD KLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI KEDELRESIEIINKTILSF",OAT,"Ornithine--oxo-acid aminotransferase; Contains: RecName: Ornithine aminotransferase, hepatic form; Contains: RecName: Ornithine aminotransferase, renal form",439,48535,7.05,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: Not Available || >>> Component: Not Available",Amino acid transport and metabolism,PF00202:Aminotran_3,HGNC:8091,Mitochondrion matrix,,"","",None,None,Non Essential,1OAT,OAT,OAT,S66421,"","" 975,Ornithine decarboxylase,2009-07-22 22:34:50 UTC,2009-08-13 06:39:49 UTC,P11926,L-ornithine = putrescine + CO(2),"",">Ornithine decarboxylase MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKC NDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELM KVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQ AISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYV ASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKY YSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV",ODC1,ODC,461,51149,4.88,">>> Function: catalytic activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid derivative metabolism Process: biogenic amine metabolism Process: polyamine metabolism Process: polyamine biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,"PF02784:Orn_Arg_deC_N PF00278:Orn_DAP_Arg_deC",HGNC:8109,"",,"","",None,None,Non Essential,1D7K,ODC1,ODC1,M20372,"","" 976,Kynurenine/alpha-aminoadipate aminotransferase mitochondrial,2009-07-22 22:34:50 UTC,2009-08-13 06:39:27 UTC,Q8N5Z0,"Shows activity also towards tryptophan, aspartate and hydroxykinurenine","",">Kynurenine/alpha-aminoadipate aminotransferase mitochondrial MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKR ALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEP AYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTS ERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPL IERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVP AAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL IKESL",AADAT,KAT/AadAT; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase II; 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AadAT,425,47352,6.96,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups || >>> Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Transcription,PF00155:Aminotran_1_2,HGNC:17929,Mitochondrion (Potential),,"","",None,None,Non Essential,"",AADAT,AADAT,BC031068,"","" 977,"4-aminobutyrate aminotransferase, mitochondrial",2009-07-22 22:34:50 UTC,2009-08-13 06:39:47 UTC,P80404,"Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine","",">4-aminobutyrate aminotransferase, mitochondrial MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEA VHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFV EKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSI LSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKY RKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPA DVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLN IFSDILADFK",ABAT,Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; GABA aminotransferase; GABA-AT; L-AIBAT; (S)-3-amino-2-methylpropionate transaminase,500,56440,8.04,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity Function: 4-aminobutyrate transaminase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid derivative metabolism Process: gamma-aminobutyric acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00202:Aminotran_3,HGNC:23,Mitochondrion matrix,,"","",None,None,Non Essential,1OHY,ABAT,ABAT,S75578,"","" 978,Pyridoxine-5'-phosphate oxidase,2009-07-22 22:34:50 UTC,2009-08-13 06:39:37 UTC,Q9NVS9,Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP),"",">Pyridoxine-5'-phosphate oxidase MTCWLRGVTATFGRPAEWPGYLSHLCGRSAAMDLGPMRKSYRGDREAFEETHLTSLDPVKQFAAWFEEAV QCPDIGEANAMCLATCTRDGKPSARMLLLKGFGKDGFRFFTNFESRKGKELDSNPFASLVFYWEPLNRQV RVEGPVKKLPEEEAECYFHSRPKSSQIGAVVSHQSSVIPDREYLRKKNEELEQLYQDQEVPKPKSWGGYV LYPQVMEFWQGQTNRLHDRIVFRRGLPTGDSPLGPMTHRGEEDWLYERLAP",PNPO,Pyridoxamine-phosphate oxidase,261,29988,7.09,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-NH2 group of donors Function: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor Function: pyridoxamine-phosphate oxidase activity Function: binding Function: nucleotide binding Function: FMN binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: vitamin metabolism Process: water-soluble vitamin metabolism Process: vitamin B6 metabolism Process: pyridoxine metabolism Process: pyridoxine biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF01243:Pyridox_oxidase,HGNC:30260,"",,"","",None,None,Non Essential,1NRG,PNPO,PNPO,BC006525,"","" 979,Sphingosine-1-phosphate lyase 1,2009-07-22 22:34:50 UTC,2009-08-13 06:39:57 UTC,O95470,"Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis","",">Sphingosine-1-phosphate lyase 1 MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRF KKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFW QEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGG TESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNT AMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISAD THKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLL HARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQ MNGSPKPH",SGPL1,SP-lyase; hSPL; Sphingosine-1-phosphate aldolase,568,63524,9.57,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:10817,Endoplasmic reticulum membrane,,"","",None,41-61,Non Essential,"",SGPL1,SGPL1,BC052991,"","" 980,Kynurenine--oxoglutarate transaminase 1,2009-07-22 22:34:51 UTC,2009-08-13 06:39:54 UTC,Q16773,"Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity)","",">Kynurenine--oxoglutarate transaminase 1 MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYP PLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPV FVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVC ITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHC PTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRK MPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV EL",CCBL1,Kynurenine--oxoglutarate transaminase I; Kynurenine aminotransferase I; KATI; Glutamine--phenylpyruvate transaminase; Glutamine transaminase K; GTK; Cysteine-S-conjugate beta-lyase,422,47876,6.45,">>> Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: lyase activity Function: carbon-sulfur lyase activity Function: 1-aminocyclopropane-1-carboxylate synthase activity || >>> Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,PF00155:Aminotran_1_2,HGNC:1564,Cytoplasm,,"","",None,None,Non Essential,1W7N,CCBL1,CCBL1,BC033685,"","" 981,Threonine synthase-like 1,2009-07-22 22:34:51 UTC,2009-08-13 06:39:28 UTC,Q8IYQ7,"","",">Threonine synthase-like 1 MLHFNRCHHLKKITQKCFSSIHVKTDKHAQRFLSRTFALAELRKSWYSTHSLVGDKNIILMGPPGAGKTT VGRIIGQKLGCCVIDVDDDILEKTWNMSVSEKLQDVGNEQFLEEEGKAVLNFSASGSVISLTGSNPMHDA SMWHLKKNGIIVYLDVPLLDLICRLKLMKTDRIVGQNSGTSMKDLLKFRRQYYKKWYDARVFCESGASPE EVADKVLNAIKRYQDVDSETFISTRHVWPEDCEQKVSAKFFSEAVIEGLASDGGLFVPAKEFPKLSCGEW KSLVGATYVERAQILLERCIHPADIPAARLGEMIETAYGENFACSKIAPVRHLSGNQFILELFHGPTGSF KDLSLQLMPHIFAHCIPPSCNYMILVATSGDTGSAVLNGFSRLNKNDKQRIAVVAFFPENGVSDFQKAQI IGSQRENGWAVGVESDFDFCQTAIKRIFNDSDFTGFLTVEYGTILSSANSINWGRLLPQVVYHASAYLDL VSQGFISFGSPVDVCIPTGNFGNILAAVYAKMMGIPIRKFICASNQNHVLTDFIKTGHYDLRERKLAQTF SPSIDILKSSNLERHLHLMANKDGQLMTELFNRLESQHHFQIEKALVEKLQQDFVADWCSEGECLAAINS TYNTSGYILDPHTAVAKVVADRVQDKTCPVIISSTAHYSKFAPAIMQALKIKEINETSSSQLYLLGSYNA LPPLHEALLERTKQQEKMEYQVCAADMNVLKSHVEQLVQNQFI",THNSL1,TSH1,743,83071,7.13,">>> Function: lyase activity Function: carbon-oxygen lyase activity Function: carbon-oxygen lyase activity, acting on phosphates Function: threonine synthase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: shikimate kinase activity Function: catalytic activity || >>> Process: aspartate family amino acid metabolism Process: threonine metabolism Process: threonine biosynthesis Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: amino acid biosynthesis Process: physiological process Process: metabolism || >>> Component: Not Available",Cell wall/membrane/envelope biogenesis,"PF00291:PALP PF01202:SKI",HGNC:26160,"",,"","",None,None,Non Essential,"",THNSL1,THNSL1,AL512598,"","" 982,"Glycogen phosphorylase, liver form",2009-07-22 22:34:51 UTC,2009-08-13 06:39:54 UTC,P06737,"Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties","",">Glycogen phosphorylase, liver form MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIR TQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRL AACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHT NTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVL YPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPEL MRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPR RWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINP SSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADV VNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEM AEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHD RFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE SNKVNGN",PYGL,"",847,97150,7.17,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring hexosyl groups Function: phosphorylase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00343:Phosphorylase,HGNC:9725,"",,"","",None,None,Non Essential,1L7X,PYGL,PYGL,M36807,"","" 983,Serine palmitoyltransferase 2,2009-07-22 22:34:51 UTC,2009-08-13 06:39:38 UTC,O15270,Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2),"",">Serine palmitoyltransferase 2 MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLV AVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICS VPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEI GNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIF KHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIG ALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRN IGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEET ED",SPTLC2,Serine-palmitoyl-CoA transferase 2; SPT 2; Long chain base biosynthesis protein 2; LCB 2,562,62925,7.85,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups || >>> Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00155:Aminotran_1_2,HGNC:11278,Endoplasmic reticulum membrane,,"","",None,67-87,Non Essential,"",SPTLC2,SPTLC2,U15555,"","" 984,Cysteine sulfinic acid decarboxylase,2009-07-22 22:34:51 UTC,2009-08-13 06:40:00 UTC,Q9Y600,3-sulfino-L-alanine = hypotaurine + CO(2),"",">Cysteine sulfinic acid decarboxylase MADSEALPSLAGDPVAVEALLRAVFGVVVDEAIQKGTSVSQKVCEWKEPEELKQLLDLELRSQGESQKQI LERCRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVG WSSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPPLALFTSKECHYSIQKGAAFLGLGTDSVRV VKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSV LLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKFYDVALDTG DKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFVPPS LRGKQESPDYHERLSKVAPVLKERMVKEGSMMIGYQPHGTRGNFFRVVVANSALTCADMDFLLNELERLG QDL",CSAD,Cysteine-sulfinate decarboxylase; Sulfinoalanine decarboxylase,493,55024,6.44,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:18966,"",,"","",None,None,Non Essential,"",CSAD,CSAD,BC105918,"","" 985,Histidine decarboxylase,2009-07-22 22:34:51 UTC,2009-08-13 06:39:53 UTC,P19113,L-histidine = histamine + CO(2),"",">Histidine decarboxylase MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVV HWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSS QGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSSVEKAGLISLVKMKF LPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTA FLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQ IPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLT ENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQHCTSQPSPRVGNL ISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDA TKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPTEASVKNGGSSRVRIFSRFPEDMMMLKKSAF KKLIKFYSVPSFPECSSQCGLQLPCCPLQAMV",HDC,HDC,662,74141,8.06,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: amino acid metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:4855,"",,"","",None,None,Non Essential,"",HDC,HDC,D16583,"","" 986,Arginine decarboxylase,2009-07-22 22:34:52 UTC,2009-08-13 06:40:01 UTC,Q96A70,Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity,"",">Arginine decarboxylase MAGYLSESDFVMVEEGFSTRDLLKELTLGASQATTDEVAAFFVADLGAIVRKHFCFLKCLPRVRPFYAVK CNSSPGVLKVLAQLGLGFSCANKAEMELVQHIGIPASKIICANPCKQIAQIKYAAKHGIQLLSFDNEMEL AKVVKSHPSAKMVLCIATDDSHSLSCLSLKFGVSLKSCRHLLENAKKHHVEVVGVSFHIGSGCPDPQAYA QSIADARLVFEMGTELGHKMHVLDLGGGFPGTEGAKVRFEEIASVINSALDLYFPEGCGVDIFAELGRYY VTSAFTVAVSIIAKKEVLLDQPGREEENGSTSKTIVYHLDEGVYGIFNSVLFDNICPTPILQKKPSTEQP LYSSSLWGPAVDGCDCVAEGLWLPQLHVGDWLVFDNMGAYTVGMGSPFWGTQACHITYAMSRVAWEALRR QLMAAEQEDDVEGVCKPLSCGWEITDTLCVGPVFTPASIM",ADC,ARGDC; ADC; Ornithine decarboxylase-like protein; ODC-paralogue; ODC-p,460,49980,5.41,">>> Function: catalytic activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid derivative metabolism Process: biogenic amine metabolism Process: polyamine metabolism Process: polyamine biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,"PF02784:Orn_Arg_deC_N PF00278:Orn_DAP_Arg_deC",HGNC:29957,"",,"","",None,None,Non Essential,"",ADC,ADC,AK095127,"","" 987,L-serine dehydratase,2009-07-22 22:34:52 UTC,2009-08-13 06:39:53 UTC,P20132,L-serine = pyruvate + NH(3),"",">L-serine dehydratase MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSSAGNAGM AAAYAARQLGVPATIVVPGTTPALTIERLKNEGATCKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPL IWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQECGWGDVPVIAMETFGAHSFHAATTAGKL VSLPKITSVAKALGVKTVGSQALKLFQEHPIFSEVISDQEAVAAIEKFVDDEKILVEPAWGAALAAVYSH VIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK",SDS,L-serine deaminase,328,34703,8.07,">>> Function: catalytic activity || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00291:PALP,HGNC:10691,Cytoplasm,,"","",None,None,Non Essential,1P5J,SDS,SDS,J05037,"","" 988,"2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial",2009-07-22 22:34:52 UTC,2009-08-13 06:39:57 UTC,O75600,Acetyl-CoA + glycine = CoA + 2-amino-3- oxobutanoate,"",">2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial MWPGNAWRAALFWVPRGRRAQSALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGILNF CANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAG LFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGD IAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGP LVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICP VMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAFVEVGRLHGALP",GCAT,AKB ligase; Glycine acetyltransferase; Aminoacetone synthetase,419,45286,8.11,">>> Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity Function: acetyltransferase activity Function: C-acetyltransferase activity Function: glycine C-acetyltransferase activity || >>> Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00155:Aminotran_1_2,HGNC:4188,Mitochondrion (By similarity),,"","",None,None,Non Essential,"",GCAT,GCAT,BC014457,"","" 989,"Glycine dehydrogenase [decarboxylating], mitochondrial",2009-07-22 22:34:52 UTC,2009-08-13 06:39:42 UTC,P23378,The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein,"",">Glycine dehydrogenase [decarboxylating], mitochondrial MQSCARAWGLRLGRGVGGGRRLAGGSGPCWAPRSRDSSSGGGDSAAAGASRLLERLLPRHDDFARRHIGP GDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILATLHAISSKNQIWRSYIGMGYYN CSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGTAAAEALQLC YRHNKRRKFLVDPRCHPQTIAVVQTRAKYTGVLTELKLPCEMDFSGKDVSGVLFQYPDTEGKVEDFTELV ERAHQSGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVG VTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSE GLKRAGHQLQHDLFFDTLKIHCGCSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKDLDDLLWIFGC ESSAELVAESMGEECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSCTM KLNSSSELAPITWKEFANIHPFVPLDQAQGYQQLFRELEKDLCELTGHDQVCFQPNSGAQGEYAGLATIR AYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMITYP STNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPI GVKKHLAPFLPNHPVISLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKQATETAILNANYM AKRLETHYRILFRGARGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMVEPTES EDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKPEN KFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS",GLDC,Glycine decarboxylase; Glycine cleavage system P-protein,1020,112714,7.14,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-NH2 group of donors Function: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor Function: glycine dehydrogenase (decarboxylating) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: glycine metabolism || >>> Component: protein complex Component: glycine dehydrogenase complex (decarboxylating)",Amino acid transport and metabolism,PF02347:GDC-P,HGNC:4313,Mitochondrion,,"","",None,None,Non Essential,"",GLDC,GLDC,D90239,"","" 990,Alanine aminotransferase 1,2009-07-22 22:34:52 UTC,2009-08-13 06:39:50 UTC,P24298,Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles,"",">Alanine aminotransferase 1 MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPFTEVIRANIGD AQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHSLGAYSVSSGIQLIREDVARYI ERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHTRTGVLIPIPQYPLYSATLAELGAVQVDYYLDE ERAWALDVAELHRALGQARDHCRPRALCVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVY AAGSQFHSFKKVLMEMGPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCP PVPGQALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSFPRVQL PPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPLEKLRLLLEKLSRFHAK FTLEYS",GPT,ALT1; Glutamic--pyruvic transaminase 1; Glutamate pyruvate transaminase 1; GPT 1; Glutamic--alanine transaminase 1,496,54638,7.20,">>> Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: lyase activity Function: carbon-sulfur lyase activity Function: 1-aminocyclopropane-1-carboxylate synthase activity || >>> Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,PF00155:Aminotran_1_2,HGNC:4552,Cytoplasm,,"","",None,None,Non Essential,"",GPT,GPT,BC018207,"","" 991,Phosphoserine aminotransferase,2009-07-22 22:34:52 UTC,2009-08-13 06:39:33 UTC,Q9Y617,Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity),"",">Phosphoserine aminotransferase MDAPRQVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSHRSSDFAKIINNTENLVRELLAVPDNY KVIFLQGGGCGQFSAVPLNLIGLKAGRCADYVVTGAWSAKAAEEAKKFGTINIVHPKLGSYTKIPDPSTW NLNPDASYVYYCANETVHGVEFDFIPDVKGAVLVCDMSSNFLSKPVDVSKFGVIFAGAQKNVGSAGVTVV IVRDDLLGFALRECPSVLEYKVQAGNSSLYNTPPCFSIYVMGLVLEWIKNNGGAAAMEKLSSIKSQTIYE IIDNSQGFYVCPVEPQNRSKMNIPFRIGNAKGDDALEKRFLDKALELNMLSLKGHRSVGGIRASLYNAVT IEDVQKLAAFMKKFLEMHQL",PSAT1,Phosphohydroxythreonine aminotransferase; PSAT,370,40423,7.77,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: L-serine metabolism Process: L-serine biosynthesis Process: physiological process Process: metabolism || >>> Component: Not Available",Coenzyme transport and metabolism,PF00266:Aminotran_5,HGNC:19129,"",,"","",None,None,Non Essential,"",PSAT1,PSAT1,BC018129,"","" 992,Serine--pyruvate aminotransferase,2009-07-22 22:34:53 UTC,2009-08-13 06:39:53 UTC,P21549,L-serine + pyruvate = 3-hydroxypyruvate + L- alanine,"",">Serine--pyruvate aminotransferase MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQT RNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVE EGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKA LNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIA EQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGG LGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQHCPKKKL",AGXT,SPT; Alanine--glyoxylate aminotransferase; AGT,392,43011,8.55,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00266:Aminotran_5,HGNC:341,Peroxisome. Mitochondrion matrix,,"","",None,None,Non Essential,1H0C,AGXT,AGXT,M61763,"","" 993,Pyridoxal phosphate phosphatase,2009-07-22 22:34:53 UTC,2009-08-13 06:39:42 UTC,Q96GD0,"Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and Pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP","",">Pyridoxal phosphate phosphatase MARCERLRGAALRDVLGRAQGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELAL RFARLGFGGLRAEQLFSSALCAARLLRQRLPGPPDAPGAVFVLGGEGLRAELRAAGLRLAGDPSAGDGAA PRVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALV VGKPSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLVP HYYVESIADLTEGLED",PDXP,PLP phosphatase,296,31699,6.51,">>> Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric monoester hydrolase activity Function: hydrolase activity Function: catalytic activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00702:Hydrolase,HGNC:30259,Cytoplasmic,,"","",None,None,Non Essential,"",PDXP,PDXP,BC064922,"","" 994,Serine palmitoyltransferase 1,2009-07-22 22:34:53 UTC,2009-08-13 06:39:28 UTC,O15269,Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2),"",">Serine palmitoyltransferase 1 MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLV PPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYG TFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFK HNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFG VLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAI EALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCM NRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL",SPTLC1,Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1; Long chain base biosynthesis protein 1; LCB 1,473,52745,5.87,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups || >>> Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00155:Aminotran_1_2,HGNC:11277,Endoplasmic reticulum membrane,,"","",None,16-36,Non Essential,"",SPTLC1,SPTLC1,AL354751,"","" 995,Cystathionine gamma-lyase,2009-07-22 22:34:53 UTC,2009-08-13 06:39:47 UTC,P32929,L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate,"",">Cystathionine gamma-lyase MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNC LEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKI KLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSA TKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFL ESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL PAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS",CTH,Gamma-cystathionase,405,44508,6.69,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF01053:Cys_Met_Meta_PP,HGNC:2501,Cytoplasm,,"","",None,None,Non Essential,"",CTH,CTH,BC015807,"","" 996,"Branched-chain-amino-acid aminotransferase, cytosolic",2009-07-22 22:34:53 UTC,2009-08-13 06:39:37 UTC,P54687,"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine","",">Branched-chain-amino-acid aminotransferase, cytosolic MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEK PHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLEC IQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKY VRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPP LDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETI HIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS",BCAT1,BCAT(c); Protein ECA39,386,42967,4.95,">>> Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity Function: branched-chain-amino-acid transaminase activity Function: catalytic activity || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: branched chain family amino acid metabolism Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF01063:Aminotran_4,HGNC:976,Cytoplasm,,"","",None,None,Non Essential,"",BCAT1,BCAT1,AK056255,"","" 997,"Branched-chain-amino-acid aminotransferase, mitochondrial",2009-07-22 22:34:53 UTC,2009-08-13 06:39:44 UTC,O15382,"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids","",">Branched-chain-amino-acid aminotransferase, mitochondrial MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKTFTDHMLMVEW NDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFD KLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVS LLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGV LELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRI LYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV",BCAT2,BCAT(m); Placental protein 18; PP18,392,44288,8.82,">>> Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity Function: branched-chain-amino-acid transaminase activity Function: catalytic activity || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: branched chain family amino acid metabolism Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF01063:Aminotran_4,HGNC:977,Isoform B:Cytoplasm,,"","",None,None,Non Essential,1KTA,BCAT2,BCAT2,BC004243,"","" 998,Proline synthetase co-transcribed bacterial homolog protein,2009-07-22 22:34:54 UTC,2009-08-13 06:39:51 UTC,O94903,"","",">Proline synthetase co-transcribed bacterial homolog protein MWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYV QELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLK VMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCK KLNIPADQVELSMGMSADFQHAVEVGSTNVRIGSTIFGERDYSKKPTPDKCAADVKAPLEVAQEH",PROSC,"",275,30344,7.57,"","",PF01168:Ala_racemase_N,HGNC:9457,"",,"","",None,None,Non Essential,"",PROSC,PROSC,BC012334,"","" 999,Formimidoyltransferase-cyclodeaminase,2009-07-22 22:34:54 UTC,2009-08-13 06:39:50 UTC,O95954,"Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool","",">Formimidoyltransferase-cyclodeaminase MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVAS RLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPA IRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARKFLIAFNINLLGTKEQAHRIALNLREQGRGK DQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLD AAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGAR SAAPGGGSVAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYL EAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDLQVAAKALEMG VFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQE",FTCD,Formiminotransferase-cyclodeaminase; FTCD; LCHC1; Glutamate formimidoyltransferase; Glutamate formiminotransferase; Glutamate formyltransferase; Formimidoyltetrahydrofolate cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase,541,58927,5.45,">>> Function: catalytic activity Function: transferase activity Function: binding Function: vitamin binding Function: folic acid binding || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,"PF02971:FTCD PF04961:FTCD_C PF07837:FTCD_N",HGNC:3974,Cytoplasm (By similarity). Golgi apparatus (By similarity),,"","",None,None,Non Essential,"",FTCD,FTCD,U91541,"","" 1000,"Aspartate aminotransferase, mitochondrial",2009-07-22 22:34:54 UTC,2009-08-13 06:39:57 UTC,P00505,Facilitates cellular uptake of long-chain free fatty acids (By similarity),"",">Aspartate aminotransferase, mitochondrial MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDD NGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEVLKSGRFVTVQTISGTGALRI GASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFTGAVEDISKIPEQSVLLLH ACAHNPTGVDPRPEQWKEIATVVKKRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKN MGLYGERVGAFTMVCKDADEAKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKGMADR IIGMRTQLVSNLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGY LAHAIHQVTK",GOT2,mAspAT; Transaminase A; Glutamate oxaloacetate transaminase 2; Fatty acid-binding protein; FABP-1; FABPpm,430,47476,9.38,">>> Function: transaminase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,PF00155:Aminotran_1_2,HGNC:4433,Mitochondrion matrix. Cell membrane (By similarity),,"","",None,None,Non Essential,"",GOT2,GOT2,BC000525,"","" 1001,"Glycogen phosphorylase, brain form",2009-07-22 22:34:54 UTC,2009-08-13 06:40:01 UTC,P11216,"Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties","",">Glycogen phosphorylase, brain form MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTVRDHLVGRWIR TQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGLDLEELEEIEEDAGLGNGGLGRL AACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHT PDGVKWLDTQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVL YPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPEL MRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFP GDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKFQNKTNGITPR RWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQENKLKFSAFLEKEYKVKINP SSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLVTSIGDV VNHDPVVGDRLKVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEM AEEAGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHD RFKVFADYEAYMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNI PRD",PYGB,"",843,96697,6.85,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring hexosyl groups Function: phosphorylase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00343:Phosphorylase,HGNC:9723,"",,"","",None,None,Non Essential,"",PYGB,PYGB,BC030795,"","" 1002,"Glycogen phosphorylase, muscle form",2009-07-22 22:34:54 UTC,2009-08-13 06:39:27 UTC,P11217,"Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties","",">Glycogen phosphorylase, muscle form MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIR TQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRL AACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHT SQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVL YPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPEL MRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPR RWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINP NSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDV VNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEM AEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHD RFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE AI",PYGM,Myophosphorylase,842,97093,7.03,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring hexosyl groups Function: phosphorylase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00343:Phosphorylase,HGNC:9726,"",,"","",None,None,Non Essential,1XL1,PYGM,PYGM,M16013,"","" 1003,"Serine hydroxymethyltransferase, mitochondrial",2009-07-22 22:34:55 UTC,2009-08-13 06:39:52 UTC,P34897,Interconversion of serine and glycine,"",">Serine hydroxymethyltransferase, mitochondrial MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRG LELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQP YSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLA LTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHK TLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREY SLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVE QFARAFPMPGFDEH",SHMT2,SHMT; Serine methylase; Glycine hydroxymethyltransferase,504,55994,8.67,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: glycine hydroxymethyltransferase activity || >>> Process: L-serine metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: glycine metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00464:SHMT,HGNC:10852,Mitochondrion,,"","",None,None,Non Essential,"",SHMT2,SHMT2,Y12331,"","" 1004,Growth-inhibiting protein 18,2009-07-22 22:34:55 UTC,2009-08-13 06:39:56 UTC,Q2TU84,L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate,"",">Aspartate aminotransferase MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHE YLPILGLAEFRSCASRLALEDDSPALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPT WENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIA SVMKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPES ILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGT WNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ",GIG18,"",413,46320,6.80,">>> Function: transaminase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,PF00155:Aminotran_1_2,HGNC:4432,"",,"","",None,None,Non Essential,1AJS,GIG18,GIG18,AY513279,"","" 1005,GAD1 protein,2009-07-22 22:34:55 UTC,2009-08-13 06:39:47 UTC,Q49AK1,"","",">GAD1 protein MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKER QSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLD FHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTAN TNMFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVP KLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVY GAFDPIQEIADICEKYNLWLHVDGFNFSQLANRIICLATELMTNKGCVTWHPNYSVNMHHGCLGRWAAHV QEAPP",GAD1,"",425,47440,7.30,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:4092,"",,"","",None,None,Non Essential,"",GAD1,GAD1,BC036552,"","" 1006,Serine hydroxymethyltransferase 2,2009-07-22 22:34:55 UTC,2009-08-13 06:39:50 UTC,Q53ET4,Interconversion of serine and glycine (By similarity),"",">Serine hydroxymethyltransferase MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRG LELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQP YSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLA LTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHK TLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREY SLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT PGGLRLGAPALTSRQFHEDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVE QFARAFPMPGFDEH","","",504,55975,8.53,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: glycine hydroxymethyltransferase activity || >>> Process: L-serine metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: glycine metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00464:SHMT,HGNC:10852,"",,"","",None,None,Non Essential,"","","",AK223555,"","" 1007,Serine hydroxymethyltransferase 1,2009-07-22 22:34:55 UTC,2009-08-13 06:39:36 UTC,Q53ET7,Interconversion of serine and glycine (By similarity),"",">Serine hydroxymethyltransferase MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLN NKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMG LDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE YARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKT GKEILYNLESLINSAVFPGLQGGPHNHAIAEVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIV TGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF","","",483,53155,7.58,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: glycine hydroxymethyltransferase activity || >>> Process: L-serine metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: glycine metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00464:SHMT,HGNC:10850,"",,"","",None,None,Non Essential,1BJ4,"","",AK223552,"","" 1008,Selenocysteine lyase variant,2009-07-22 22:34:55 UTC,2009-08-13 06:39:30 UTC,Q59FK2,"","",">Selenocysteine lyase variant FSNPFCGETFPRKPDLKGTHRWAPQPSEGGQAPFHYFLGGTRLHPAAPGAPGGRTSGSLLNVKMMKMKTF MMICFHLINTVTFVPVSKVSGQTEVDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQERVA AGLPPILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPRIGALYIRGLGEFTPLYPMLFGGGQERNF RPGTENTPMIAGLGKVSPGELEEMS","","",235,25485,9.14,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00266:Aminotran_5,HGNC:18161,"",,"","",None,None,Non Essential,"","","",AB209458,"","" 1009,Brain glycogen phosphorylase variant,2009-07-22 22:34:56 UTC,2009-08-13 06:39:30 UTC,Q59GM9,"Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)","",">Phosphorylase IPAFACAAAFLLHLFSSASAGAMAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVAT PRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGL DLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEADDWLRYGN PWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLQDF NVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVASTLQDIIRRFKSSKFGCRDPVRTCFE TFPDKVAIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLP RHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSV FKDFYELEPEKFQNKTNGITPRRWLLLCNPGLANTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKV KQENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFVPRTVMIGG KAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTG NMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELKQAVDQISS GFFSPKEPDCFKDIVNMLMHHDRFKVFADYEAYMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTI TEYAREIWGVEPSDLQIPPPNIPRD","","",865,98831,6.95,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring hexosyl groups Function: phosphorylase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00343:Phosphorylase,HGNC:9723,"",,"","",None,None,Non Essential,"","","",AB209080,"","" 1010,Ornithine aminotransferase variant,2009-07-22 22:34:56 UTC,2009-08-13 06:39:47 UTC,Q59HE2,"","",">Ornithine aminotransferase variant ILGFFEIITVCFPFVAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFM VEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGL YPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVV TAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILS F","","",281,30737,4.46,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: Not Available || >>> Component: Not Available",Amino acid transport and metabolism,PF00202:Aminotran_3,HGNC:8091,"",,"","",None,None,Non Essential,1OAT,"","",AB208817,"","" 1011,SHMT2 protein,2009-07-22 22:34:56 UTC,2009-08-13 06:39:46 UTC,Q5BJF5,Interconversion of serine and glycine (By similarity),"",">Serine hydroxymethyltransferase ELRCCTSLCFGRLGLCRDVGSWSGWPFGLSTATQPRLRLGKQTGAGQARRACRTVILRCGSCCRGRRTGS VVAWSSLPQRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGL DLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDY ARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTG REIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVS GGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRV VDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDEH",SHMT2,"",480,52910,9.66,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: glycine hydroxymethyltransferase activity || >>> Process: L-serine metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: glycine metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00464:SHMT,HGNC:10852,"",,"","",None,None,Non Essential,"",SHMT2,SHMT2,BC091501,"","" 1012,Hypothetical protein DKFZp686P09201,2009-07-22 22:34:56 UTC,2009-08-13 06:39:43 UTC,Q5HYG8,Interconversion of serine and glycine (By similarity),"",">Serine hydroxymethyltransferase MAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSC LNNKYPEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRI MGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARL IDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDP KTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYS LVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDF RRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDEH",DKFZp686P09201,"",483,53466,8.27,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: glycine hydroxymethyltransferase activity || >>> Process: L-serine metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: glycine metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00464:SHMT,HGNC:10852,"",,"","",None,None,Non Essential,"",DKFZp686P09201,DKFZp686P09201,BX647711,"","" 1013,Migration-inducing protein 4,2009-07-22 22:34:56 UTC,2009-08-13 06:39:54 UTC,Q5JAM2,"","",">Migration-inducing protein 4 MESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKT AKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAV RKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPERVSHLLQDNLPKSVSTFQYDRFFEKKIDEK KNDHTYRVFKTVNRRAHIFPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGT RNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSR VPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYG ARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVR ILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINY PTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLELKPHSSAECNFCRRPLHFEVMSEREKSYFS GLSKLVSAQA",ALAS1,"SubName: Aminolevulinate, delta-, synthase 1, isoform CRA_a; SubName: cDNA, FLJ92941, Homo sapiens aminolevulinate, delta-, synthase 1 (ALAS1), nuclear gene encoding mitochondrial protein, mRNA",640,70582,8.57,">>> Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity Function: N-acyltransferase activity Function: N-succinyltransferase activity Function: 5-aminolevulinate synthase activity || >>> Process: biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis Process: heme biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00155:Aminotran_1_2,HGNC:396,"",,"","",None,None,Non Essential,"",ALAS1,ALAS1,CH471055,"","" 1014,Phosphorylase,2009-07-22 22:34:56 UTC,2009-08-13 06:39:43 UTC,Q5JWL9,"Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)","",">Phosphorylase KHHHTVPPSVTPKALDRSPPCPEMFTRAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVS LAEKVIPAADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVEAL DRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEAYMQCQAQVDQLY RNPKEWTKKVIRNIACSGKFSSDRTITEYAREIW",PYGB,"",244,27446,6.31,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring hexosyl groups Function: phosphorylase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00343:Phosphorylase,HGNC:9723,"",,"","",None,None,Non Essential,"",PYGB,PYGB,AL121772,"","" 1015,Phosphoserine aminotransferase 1,2009-07-22 22:34:56 UTC,2009-08-13 06:39:42 UTC,Q5T7G6,"","",">Phosphoserine aminotransferase MDAPRQVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSHRSSDFAKIINNTENLVRELLAVPDNY KVIFLQGGGCGQFSAVPLNLIGLKAGRCADYVVTGAWSAKAAEEAKKFGTINIVHPKLGSYTKIPDPSTW NLNPDASYVYYCANETVHGVEFDFIPDVKGAVLVCDMSSNFLSKPVDVSKFGVIFAGAQKNVGSAGVTVV IVRDDLLGFALRECPSVLEYKVQAGNSSLYNTPPCFSIYVMGLVLEWIKNNGGAAAMEKLSSIKSQTIYE IIDNSQGFYVCPVEPQNRSKMNIPFRIGNAKGDDALEKRFLDKALELNMLSLKGHRSVGGIRASLYNAVT IEDVQKLAAFMKKFLEMHQL",PSAT1,"SubName: Phosphoserine aminotransferase 1; SubName: Phosphoserine aminotransferase 1, isoform CRA_d",370,40423,7.77,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: L-serine metabolism Process: L-serine biosynthesis Process: physiological process Process: metabolism || >>> Component: Not Available",Coenzyme transport and metabolism,PF00266:Aminotran_5,HGNC:19129,"",,"","",None,None,Non Essential,"",PSAT1,PSAT1,CH471089,"","" 1016,Glutamate decarboxylase 2,2009-07-22 22:34:57 UTC,2009-08-13 06:39:45 UTC,Q5VZ30,"","",">Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa) (Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_b) MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARK AACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNE LLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIA PVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEH SHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAV ADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREG YEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMV ISNPAATHQDIDFLIEEIERLGQDL",GAD2,"",585,65412,6.89,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:4093,"",,"","",None,None,Non Essential,"",GAD2,GAD2,CH471072,"","" 1017,Putative L-Dopa decarboxylase,2009-07-22 22:34:57 UTC,2009-08-13 06:39:45 UTC,Q5W5T9,"","",">Putative L-Dopa decarboxylase MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTH WHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEG GGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIP SDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFI CPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWSRQPVRMLRLKKTCLVSAVVRRS",DDC,"",338,37086,5.41,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: amino acid metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:2719,"",,"","",None,None,Non Essential,1JS3,DDC,DDC,AJ310724,"","" 1018,OAT protein,2009-07-22 22:34:57 UTC,2009-07-22 22:34:57 UTC,Q6IAV9,,,,,,,,,,,,,,,,,,,,,,,,, 1019,DDC protein,2009-07-22 22:34:57 UTC,2009-08-13 06:39:59 UTC,Q6IBS8,"","",">DDC protein MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTH WHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEG GGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIP SDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFI CPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQ IPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERD",DDC,"",480,53881,7.21,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: amino acid metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:2719,"",,"","",None,None,Non Essential,1JS3,DDC,DDC,CR456724,"","" 1020,KIAA0251 protein,2009-07-22 22:34:57 UTC,2009-08-13 06:39:32 UTC,Q6P996,"","",">Pyridoxal-dependent decarboxylase domain-containing protein 1 MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVSILQLVQNLMH GDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSDTTLWLCRIFRYENGCAYFHE EEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVF GSQHQMDVAFLEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALG YVSSSVLAAAKCDSMTMTPGPWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGL DGFVERIKHACQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVACIESKLPVLC CTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPEGENIHAGLLKKLNELESDLT FKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIEENSRLLENMTEVVRKGIQEAQVELQKASEE RLLEEGVLRQIPVVGSVLNWFSPVQALQKGRTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQR LPGQKPFKRSLRGSDALSETSSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKG VPHPEDDHSQVEGPESLR",PDXDC1,"",788,86708,5.05,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:28995,"",,"","",None,None,Non Essential,"",PDXDC1,PDXDC1,DQ111782,"","" 1021,Kynurenine--oxoglutarate transaminase 3,2009-07-22 22:34:57 UTC,2009-08-13 06:39:51 UTC,Q6YP21,"Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity)","",">Kynurenine--oxoglutarate transaminase 3 MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLAADPSVVNLGQ GFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFN TIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPVYGKRWSSSDWTLDPQELESKFNSKTKA IILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGK TFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKR DRMVRLLESVGLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSET KSQFEKFVRFCFIKKDSTLDAAEEIIKAWSVQKS",CCBL2,Kynurenine--oxoglutarate transaminase III; Kynurenine aminotransferase III; KATIII; Cysteine-S-conjugate beta-lyase 2,454,51401,8.34,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups || >>> Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,PF00155:Aminotran_1_2,HGNC:33238,"",,"","",None,None,Non Essential,"",CCBL2,CCBL2,CR450282,"","" 1022,"CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase",2009-07-22 22:34:58 UTC,2009-08-13 06:39:57 UTC,Q6ZQY3,"","",">Glutamate decarboxylase-like protein 1 MIPSKKNAVLVDGVVLNGPTTDAKAGEKFVEEACRLIMEEVVLKATDVNEKVCEWRPPEQLKQLLDLEMR DSGEPPHKLLELCRDVIHYSVKTDHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAV LKKMIEFIGWKEGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSGSPRLILFTSAECHYSMKKAASFL GIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHSLWLH VDASWGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDK FYDVSYDTGDKSIQCSRRPDAFKFWMTWKALGTLGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYAN ICFWYIPPSLREMEEGPEFWAKLNLVAPAIKERMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDMDF LLDEIDLLGKDM",GADL1,"",502,57141,6.88,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:27949,"",,"","",None,None,Non Essential,"",GADL1,GADL1,BC111986,"","" 1023,SCLY protein,2009-07-22 22:34:58 UTC,2009-07-22 22:34:58 UTC,Q7L670,,,,,,,,,,,,,,,,,,,,,,,,, 1024,IGSF10 protein,2009-07-22 22:34:58 UTC,2009-07-22 22:34:58 UTC,Q86YJ9,,,,,,,,,,,,,,,,,,,,,,,,, 1025,Alanine--glyoxylate aminotransferase 2-like 2,2009-07-22 22:34:58 UTC,2009-08-13 06:39:46 UTC,Q8IUZ5,"","",">Alanine--glyoxylate aminotransferase 2-like 2 MAADQRPKADTLALRQRLISSSCRLFFPEDPVKIVRAQGQYMYDEQGAEYIDCISNVAHVGHCHPLVVQA AHEQNQVLNTNSRYLHDNIVDYAQRLSETLPEQLCVFYFLNSGSEANDLALRLARHYTGHQDVVVLDHAY HGHLSSLIDISPYKFRNLDGQKEWVHVAPLPDTYRGPYREDHPNPAMAYANEVKRVVSSAQEKGRKIAAF FAESLPSVGGQIIPPAGYFSQVAEHIRKAGGVFVADEIQVGFGRVGKHFWAFQLQGKDFVPDIVTMGKSI GNGHPVACVAATQPVARAFEATGVEYFNTFGGSPVSCAVGLAVLNVLEKEQLQDHATSVGSFLMQLLGQQ KIKHPIVGDVRGVGLFIGVDLIKDEATRTPATEEAAYLVSRLKENYVLLSTDGPGRNILKFKPPMCFSLD NARQVVAKLDAILTDMEEKVRSCETLRLQP",AGXT2L2,"",450,49711,6.76,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: Not Available || >>> Component: Not Available",Amino acid transport and metabolism,PF00202:Aminotran_3,HGNC:28249,Mitochondrion (Potential),,"","",None,None,Non Essential,"",AGXT2L2,AGXT2L2,BC110335,"","" 1026,Glutamate decarboxylase 1,2009-07-22 22:34:58 UTC,2009-08-13 06:39:47 UTC,Q8IVA8,"","",">Glutamate decarboxylase 1 (Brain, 67kDa) MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKER QSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLD FHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTAN TNMFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVP KLVLFTSEQSRYSIKKAGAALGFGTDNVILIKCNERGEIIPADFEAKILEAKQKGYVPFYVNATAGTTVY GAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKE KGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYL YAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQG DKANFFRMVISNPAATQSDIDFLIEEIERLGQDL",GAD1,"",594,66917,7.48,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:4092,"",,"","",None,None,Non Essential,"",GAD1,GAD1,BC037780,"","" 1027,SHMT2 protein,2009-07-22 22:34:58 UTC,2009-08-13 06:39:50 UTC,Q8N1A5,Interconversion of serine and glycine (By similarity),"",">Serine hydroxymethyltransferase MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRG LELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQP YSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNLALTARLFRPRL IIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLI FYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPA LTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPG FDEH",SHMT2,"",494,54863,8.68,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: glycine hydroxymethyltransferase activity || >>> Process: L-serine metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: glycine metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00464:SHMT,HGNC:10852,"",,"","",None,None,Non Essential,"",SHMT2,SHMT2,CH471054,"","" 1028,BCAT1 protein,2009-07-22 22:34:58 UTC,2009-07-22 22:34:58 UTC,Q8N4L9,,,,,,,,,,,,,,,,,,,,,,,,, 1029,"Aminolevulinate, delta-, synthase 2",2009-07-22 22:34:59 UTC,2009-08-13 06:39:49 UTC,Q8N6H3,"","",">Aminolevulinate, delta-, synthase 2 MRGGEVALGWNKKKRLFCEDFRFKMVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGP NCSQIHLKATKAGGDSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTGNYVFSYDQFFRDKI MEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGVGA GGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIR NSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVG LYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALE SVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQA INYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERS YFGNMGPQYVTTYA",ALAS2,"",574,63516,8.52,">>> Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity Function: N-acyltransferase activity Function: N-succinyltransferase activity Function: 5-aminolevulinate synthase activity || >>> Process: biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis Process: heme biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,"PF00155:Aminotran_1_2 PF09029:Preseq_ALAS",HGNC:397,"",,"","",None,None,Non Essential,"",ALAS2,ALAS2,BC030230,"","" 1030,Alanine aminotransferase 2,2009-07-22 22:34:59 UTC,2009-08-13 06:39:34 UTC,Q8TD30,L-alanine + 2-oxoglutarate = pyruvate + L- glutamate,"",">Alanine aminotransferase 2 MQRAAALVRRGCGPRTPSSWGRSQSSAAAEASAVLKVRPERSRRERILTLESMNPQVKAVEYAVRGPIVL KAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQ ACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVM IPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRK CIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYR GGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLT EDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGT YHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA",GPT2,ALT2; Glutamic--pyruvic transaminase 2; Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2,523,57904,7.77,">>> Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: lyase activity Function: carbon-sulfur lyase activity Function: 1-aminocyclopropane-1-carboxylate synthase activity || >>> Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,PF00155:Aminotran_1_2,HGNC:18062,"",,"","",None,None,Non Essential,"",GPT2,GPT2,BC062555,"","" 1031,Molybdenum cofactor sulfurase,2009-07-22 22:34:59 UTC,2009-08-13 06:39:44 UTC,Q96EN8,Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form,"",">Molybdenum cofactor sulfurase MAGAAAESGRELWTFAGSRDPSAPRLAYGYGPGSLRELRAREFSRLAGTVYLDHAGATLFSQSQLESFTS DLMENTYGNPHSQNISSKLTHDTVEQVRYRILAHFHTTAEDYTVIFTAGSTAALKLVAEAFPWVSQGPES SGSRFCYLTDSHTSVVGMRNVTMAINVISIPVRPEDLWSAEERGASASNPDCQLPHLFCYPAQSNFSGVR YPLSWIEEVKSGRLRPVSTPGKWFVLLDAASYVSTSPLDLSAHQADFVPISFYKIFGFPTGLGALLVHNR AAPLLRKTYFGGGTASAYLAGEDFYIPRQSVAQRFEDGTISFLDVIALKHGFDTLERLTGGMENIKQHTF TLAQYTYMALSSLQYPNGAPVVRIYSDSEFSSPEVQGPIINFNVLDDKGNIIGYSQVDKMASLYNIHLRT GCFCNTGACQRHLGISNEMVRKHFQAGHVCGDNMDLIDGQPTGSVRISFGYMSTLDDVQAFLRFIIDTRL HSSGDWPVPQAHADTGETGAPSADSQADVIPAVMGRRSLSPQEDALTGSRVWNNSSTVNAVPVAPPVCDV ARTQPTPSEKAAGVLEGALGPHVVTNLYLYPIKSCAAFEVTRWPVGNQGLLYDRSWMVVNHNGVCLSQKQ EPRLCLIQPFIDLRQRIMVIKAKGMEPIEVPLEENSERTQIRQSRVCADRVSTYDCGEKISSWLSTFFGR PCHLIKQSSNSQRNAKKKHGKDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTSDENGKEELFSLKD LSLRFRANIIINGKRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVN FGMYLMHASLDLSSPCFLSVGSQVLPVLKENVEGHDLPASEKHQDVTS",MOCOS,MoCo sulfurase; HMCS; MOS,888,98154,6.72,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF00266:Aminotran_5 PF03473:MOSC PF03476:MOSC_N",HGNC:18234,"",,"","",None,None,Non Essential,"",MOCOS,MOCOS,AL834481,"","" 1032,Serine dehydratase-like,2009-07-22 22:34:59 UTC,2009-08-13 06:39:59 UTC,Q96GA7,"","",">Serine dehydratase-like MDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCS SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGWENVP PFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAA ITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAAL AAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNINSRELQALKTHLGQV",SDSL,Serine dehydratase 2,329,34675,6.88,">>> Function: catalytic activity || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00291:PALP,HGNC:30404,"",,"","",None,None,Non Essential,"",SDSL,SDSL,BC091479,"","" 1033,Serine hydroxymethyltransferase 1,2009-07-22 22:34:59 UTC,2009-08-13 06:39:47 UTC,Q96HY0,Interconversion of serine and glycine (By similarity),"",">Serine hydroxymethyltransferase MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLN NKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMG LDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE YARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKT GKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIV TGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASFFPLPGLPDF",SHMT1,"",483,53117,7.77,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: glycine hydroxymethyltransferase activity || >>> Process: L-serine metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: glycine metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00464:SHMT,HGNC:10850,"",,"","",None,None,Non Essential,1BJ4,SHMT1,SHMT1,CH471196,"","" 1034,P-selectin cytoplasmic tail-associated protein,2009-07-22 22:34:59 UTC,2009-08-13 06:39:47 UTC,Q96JQ3,"","",">P-selectin cytoplasmic tail-associated protein (PCAP) MGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNP HKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQG DQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFVPPSLRGKQESPDYHERLSKVAPVLKE RMVKEGSMMIGYQPHGTRGNFFRVVVANSALTCADMDFLLNELERLGQDL",pcap,"",260,29223,6.71,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:18966,"",,"","",None,None,Non Essential,"",pcap,pcap,AB044561,"","" 1035,Hepatic peroxysomal alanine:glyoxylate aminotransferase,2009-07-22 22:35:00 UTC,2009-08-13 06:39:32 UTC,Q9BXA1,"","",">Hepatic peroxysomal alanine:glyoxylate aminotransferase SNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSF LVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFG ELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLIFFSDKAKKKMYSRKTKPFSF YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLF VKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEAL RAALQHCKANL","","",361,39775,7.36,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00266:Aminotran_5,HGNC:341,"",,"","",None,None,Non Essential,1H0C,"","",AF348451,"","" 1036,Serine racemase,2009-07-22 22:35:00 UTC,2009-08-13 06:39:51 UTC,Q9GZT4,Catalyzes the synthesis of D-serine from L-serine,"",">Serine racemase MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPD ALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAK RVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAE PSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKL LIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV",SRR,"",340,36567,6.51,">>> Function: catalytic activity || >>> Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00291:PALP,HGNC:14398,"",,"","",None,None,Non Essential,"",SRR,SRR,BC074728,"","" 1037,O-phosphoseryl-tRNA(Sec) selenium transferase,2009-07-22 22:35:00 UTC,2009-08-13 06:39:58 UTC,Q9HD40,Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis,"",">O-phosphoseryl-tRNA(Sec) selenium transferase MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAIMDSNNFLGNC GVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLDIIKLAGVHTVANCFVV PMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQ ELGPDCILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQ SLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSN QIKKLSEAYNERLLHTPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVSGYTFR GFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLDRCLKAVRKERSKESDDNYDKTEDVDIEEMALKLDN VLLDTYQDASS",SEPSECS,Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein; Liver-pancreas antigen; LP; Soluble liver antigen; SLA; SLA/LP autoantigen; SLA-p35,501,55727,8.13,"","",PF05889:SLA_LP_auto_ag,HGNC:30605,Cytoplasm,,"","",None,None,Non Essential,"",SEPSECS,SEPSECS,AF282065,"","" 1038,Uncharacterized protein C20orf38,2009-07-22 22:35:00 UTC,2009-08-13 06:39:52 UTC,Q9NUV7,Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2),"",">Serine palmitoyltransferase 3 MANPGGGAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDKLIVESFEEAPLHVMVFTYMGY GIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYMRIRDNWNRPICSAPGPLFDL MERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKE LEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSL EKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRG VTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMG LDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKKIGVVVVGF PATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDETSFELED",SPTLC3,Serine-palmitoyl-CoA transferase 3; SPT 3; Long chain base biosynthesis protein 3; LCB 3,552,62050,9.05,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups || >>> Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00155:Aminotran_1_2,HGNC:16253,Endoplasmic reticulum membrane,,"","",None,59-79,Non Essential,"",SPTLC3,SPTLC3,BC020656,"","" 1039,Putative selenocysteine lyase,2009-07-22 22:35:00 UTC,2009-07-22 22:35:00 UTC,Q9NZR7,,,,,,,,,,,,,,,,,,,,,,,,, 1040,Glutamic acid decarboxylase,2009-07-22 22:35:00 UTC,2009-08-13 06:39:42 UTC,Q9UGI5,"","",">Glutamic acid decarboxylase LKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGD GIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDE RGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRK HKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQC GRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTL EDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL",GAD65,"",419,47345,8.44,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:4093,"",,"","",None,None,Non Essential,"",GAD65,GAD65,AJ251501,"","" 1041,Alanine-glyoxylate aminotransferase homolog,2009-07-22 22:35:00 UTC,2009-08-13 06:39:49 UTC,Q9UJX1,"","",">Alanine-glyoxylate aminotransferase homolog MALRGPGLERPPLTCPELRQEQCCGGCQVGGAGPERRGGLGASTLSPGPDPLQPCVAQQPFPSLPSPLPL QGTLHSSPPGATGRPPLCLSEPSSVSPRPRCFLLPWGSPRPCPRQSQTGGSRGSPAPRPAESGSSSRTTE GGASCPPHPCHCPPAPSPTQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDW RDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQHCPKKKL",TLH6,"",270,28430,8.62,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: transaminase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00266:Aminotran_5,"","",,"","",None,None,Non Essential,1H0C,TLH6,"",AF191687,"","" 1042,Cysteine sulfinic acid decarboxylase-related protein 1,2009-07-22 22:35:01 UTC,2009-08-13 06:39:44 UTC,Q9Y602,"","",">Cysteine sulfinic acid decarboxylase-related protein 1 MADSEALPSLAGDPVAVEALLRAVFGVVVDEAIQKGTSVSQKVCEWKEPEELKQLLDLELRSQGESQKQI LERCRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVG WSSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPPLALFTSKEVGKRHRPNPGLLILISSHVTT PSRRELRFWDLAPTVSEWSRLMREGKWSPRIWRGRLVWPRLRVLCRSWSVPPLAPLC",CSAD,"SubName: Cysteine sulfinic acid decarboxylase, isoform CRA_c",267,30264,9.85,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism || >>> Component: Not Available","",PF00282:Pyridoxal_deC,"","",,"","",None,None,Non Essential,"",CSAD,"",CH471054,"","" 1043,Amnionless protein,2009-07-22 22:35:01 UTC,2009-08-13 06:39:50 UTC,Q9BXJ7,Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity),"",">Protein amnionless MGVLGRVLLWLQLCALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDML LPLDGELVLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHD DVFFPPSASFRVGLGPGASPVRVRSISALGRTFTRDEDLAVFLASRAGRLRFHGPGALSVGPEDCADPSG CVCGNAEAQPWICAALLQPLGGRCPQAACHFALRPQGQCCDLCGAVVLLTHGPAFDLERYRARILDTFLG LPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMRESG AHVWGSSAAGLAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPVFDVTASEELP LPRRLSLVPKAAADSTSHSYFVNPLFAGAEAEA",AMN,"",453,47815,6.09,"","","",HGNC:14604,Membrane,,"","",1-19,358-378,Non Essential,"",AMN,AMN,AY358468,"","" 1044,Transcobalamin-1,2009-07-22 22:35:01 UTC,2009-08-13 06:39:51 UTC,P20061,Vitamin B12-binding protein. Transports cobalamin into cells,"",">Transcobalamin-1 MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQT LMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTP LTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKAD EGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGA FSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNV TVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVV RNGENLEVRWSKY",TCN1,Transcobalamin I; TC I; TCI,433,48207,4.68,">>> Function: binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available","",PF01122:Cobalamin_bind,HGNC:11652,Secreted,,"","",1-23,None,Non Essential,"",TCN1,TCN1,J05068,"","" 1045,"Methionine synthase reductase, mitochondrial",2009-07-22 22:35:01 UTC,2009-08-13 06:39:37 UTC,Q9UBK8,Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state,"",">Methionine synthase reductase, mitochondrial MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDK YDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDK RLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASLRTDLVKSE LLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVH LQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSE VQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTS DSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHP GKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLP DDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILT HLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVG VEKLEAMKTLATLKEEKRYLQDIWS",MTRR,MSR,725,80437,6.47,">>> Function: binding Function: nucleotide binding Function: FMN binding Function: transporter activity Function: electron transporter activity Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Inorganic ion transport and metabolism,"PF00667:FAD_binding_1 PF00258:Flavodoxin_1 PF00175:NAD_binding_1",HGNC:7473,Isoform A:Mitochondrion (Probable),,"","",None,None,Non Essential,"",MTRR,MTRR,BC109216,"","" 1046,Transcobalamin-2,2009-07-22 22:35:01 UTC,2009-08-13 06:39:47 UTC,P20062,Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells,"",">Transcobalamin-2 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKED LYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKR AIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLLYAVEPFHQGHHSVDTAAMAGLAFTCLKRSN FNPGRRQRITMAIRTVREEILKAQTPEGHFGNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQD GAFQNALMISQLLPVLNHKTYIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVL AGSTVEDVLKKAHELGGFTYETQASSSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI ELRLVSW",TCN2,Transcobalamin II; TC II; TCII,427,47451,6.89,">>> Function: binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available","",PF01122:Cobalamin_bind,HGNC:11653,Secreted,,"","",1-18,None,Non Essential,"",TCN2,TCN2,BC001176,"","" 1047,"Methylmalonic aciduria type A protein, mitochondrial",2009-07-22 22:35:01 UTC,2009-08-13 06:39:53 UTC,Q8IVH4,May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis,"",">Methylmalonic aciduria type A protein, mitochondrial MPMLLPHPHQHFLKGLLRAPFRCYHFIFHSSTHLGSGIPCAQPFNSLGLHCTKWMLLSDGLKRKLCVQTT LKDHTEGLSDKEQRFVDKLYTGLIQGQRACLAEAITLVESTHSRKKELAQVLLQKVLLYHREQEQSNKGK PLAFRVGLSGPPGAGKSTFIEYFGKMLTERGHKLSVLAVDPSSCTSGGSLLGDKTRMTELSRDMNAYIRP SPTRGTLGGVTRTTNEAILLCEGAGYDIILIETVGVGQSEFAVADMVDMFVLLLPPAGGDELQGIKRGII EMADLVAVTKSDGDLIVPARRIQAEYVSALKLLRKRSQVWKPKVIRISARSGEGISEMWDKMKDFQDLML ASGELTAKRRKQQKVWMWNLIQESVLEHFRTHPTVREQIPLLEQKVLIGALSPGLAADFLLKAFKSRD",MMAA,"",418,46539,9.83,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: binding Function: nucleotide binding || >>> Process: Not Available || >>> Component: Not Available",Amino acid transport and metabolism,PF03308:ArgK,HGNC:18871,Mitochondrion (Probable),,"","",None,None,Non Essential,"",MMAA,MMAA,BC101179,"","" 1048,"Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial",2009-07-22 22:35:01 UTC,2009-08-13 06:39:46 UTC,Q96EY8,"ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide","",">Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial MAVCGLGSRLGLGSRLGLRGCFGAARLLYPRFQSRGPQGVEDGDRPQPSSKTPRIPKIYTKTGDKGFSST FTGERRPKDDQVFEAVGTTDELSSAIGFALELVTEKGHTFAEELQKIQCTLQDVGSALATPCSSAREAHL KYTTFKAGPILELEQWIDKYTSQLPPLTAFILPSGGKISSALHFCRAVCRRAERRVVPLVQMGETDANVA KFLNRLSDYLFTLARYAAMKEGNQEKIYMKNDPSAESEGL",MMAB,Cob(I)alamin adenosyltransferase; Methylmalonic aciduria type B protein,250,27389,8.78,"","",PF01923:Cob_adeno_trans,HGNC:19331,Mitochondrion (Probable),,"","",None,None,Non Essential,"",MMAB,MMAB,BC011831,"","" 1049,Cubilin,2009-07-22 22:35:01 UTC,2009-08-13 06:39:57 UTC,O60494,"Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands required calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface","",">Cubilin MMNMSLPFLWSLLTLLIFAEVNGEAGELELQRQKRSINLQQPRMATERGNLVFLTGSAQNIEFRTGSLGK IKLNDEDLSECLHQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDLERKFQGLQQTVDKKVCSSNP CQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQC ASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMSSPNSPACTLDRDECSFQPGPCSTLVQC FNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLT DICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKC DSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSP DVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSS DNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTF TFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYL TSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRD GETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTGEGVIRSPFFPNVYPGER TCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTF VKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLE FHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATACLQ DYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLL GIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSE CYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLR TDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHH INCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATG SFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRS PENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVI RVDRNHRVLLNFTDFDLESQDSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNR GFRAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFV EILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGGTFYMAEGIFN SPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNY SSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVV HGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEW FAVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNILSLDIESHR TCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGYLHADR GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDIYSPPLGPPG GNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLACGGNVYIHDADSAGYVTSPNHPHN YPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGE VMYLRFRSDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFE DFNLQNSSGCEKDFVEIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSME ECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNS PQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEGNFTSPGYDGV RNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKPTLPLVI PYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLT FSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNT QTLGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAG TEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQY DNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIA GPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKF SDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQT LGPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYV KLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQN ISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNASA VPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQN HTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY EIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLT LYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTWDS",CUBN,Intrinsic factor-cobalamin receptor; Intrinsic factor-vitamin B12 receptor; 460 kDa receptor; Intestinal intrinsic factor receptor,3623,398729,5.00,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: Not Available || >>> Component: Not Available","","PF00431:CUB PF00008:EGF PF07645:EGF_CA",HGNC:2548,Endosome membrane,,"","",1-23,None,Non Essential,"",CUBN,CUBN,AL731551,"","" 1050,"Methylmalonyl-CoA mutase, mitochondrial",2009-07-22 22:35:01 UTC,2009-08-13 06:39:45 UTC,P22033,"Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species","",">Methylmalonyl-CoA mutase, mitochondrial MLRAKNQLFLLSPHYLRQVKESSGSRLIQQRLLHQQQPLHPEWAALAKKQLKGKNPEDLIWHTPEGISIK PLYSKRDTMDLPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDL ATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLANFIVTGEEQGVPK EKLTGTIQNDILKEFMVRNTYIFPPEPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAILELAYT LADGLEYSRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAH CQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPK VADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVN KYQLEKEDAVEVLAIDNTSVRNRQIEKLKKIKSSRDQALAERCLAALTECAASGDGNILALAVDASRARC TVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSAIKRVHKFMEREGRRPRLLVAKMGQDGHDRG AKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELNSLGRPDILVM CGGVIPPQDYEFLFEVGVSNVFGPGTRIPKAAVQVLDDIEKCLEKKQQSV",MUT,MCM; Methylmalonyl-CoA isomerase,750,83121,6.92,">>> Function: intramolecular transferase activity Function: methylmalonyl-CoA mutase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: cobalt ion binding Function: catalytic activity Function: isomerase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,"PF02310:B12-binding PF01642:MM_CoA_mutase",HGNC:7526,Mitochondrion matrix,,"","",None,None,Non Essential,"",MUT,MUT,BC016282,"","" 1051,Methylmalonic aciduria and homocystinuria type C protein,2009-07-22 22:35:01 UTC,2009-08-13 06:39:42 UTC,Q9Y4U1,May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12),"",">Methylmalonic aciduria and homocystinuria type C protein MEPKVAELKQKIEDTLCPFGFEVYPFQVAWYNELLPPAFHLPLPGPTLAFLVLSTPAMFDRALKPFLQSC HLRMLTDPVDQCVAYHLGRVRESLPELQIEIIADYEVHPNRRPKILAQTAAHVAGAAYYYQRQDVEADPW GNQRISGVCIHPRFGGWFAIRGVVLLPGIEVPDLPPRKPHDCVPTRADRIALLEGFNFHWRDWTYRDAVT PQERYSEEQKAYFSTPPAQRLALLGLAQPSEKPSSPSPDLPFTTPAPKKPGNPSRARSWLSPRVSPPASP GP",MMACHC,"",282,31729,7.92,"","","",HGNC:24525,"",,"","",None,None,Non Essential,"",MMACHC,MMACHC,AL451136,"","" 1052,Vitamin B12-binding protein,2009-07-22 22:35:01 UTC,2009-08-13 06:39:48 UTC,P37028,Part of the ABC transporter complex btuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of btuC,"",">Vitamin B12-binding protein MAKSLFRALVALSFLAPLWLNAAPRVITLSPANTELAFAAGITPVGVSSYSDYPPQAQKIEQVSTWQGMN LERIVALKPDLVIAWRGGNAERQVDQLASLGIKVMWVDATSIEQIANALRQLAPWSPQPDKAEQAAQSLL DQYAQLKAQYADKPKKRVFLQFGINPPFTSGKESIQNQVLEVCGGENIFKDSRVPWPQVSREQVLARSPQ AIVITGGPDQIPKIKQYWGEQLKIPVIPLTSDWFERASPRIILAAQQLCNALSQVD",btuF,"",266,29367,9.07,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: iron ion transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: transition metal ion transport Process: iron ion transport Process: high affinity iron ion transport || >>> Component: Not Available",Inorganic ion transport and metabolism,PF01497:Peripla_BP_2,"",Periplasm,,"","",1-22,None,Essential,1N2Z,btuF,"",AP009048,"","" 1053,Vitamin B12 transporter btuB,2009-07-22 22:35:01 UTC,2009-08-13 06:39:37 UTC,P06129,"Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein tonB. Is also a receptor for bacteriophages BF23 and C1, and for A and E colicins","",">Vitamin B12 transporter btuB MIKKASLLTACSVTAFSAWAQDTSPDTLVVTANRFEQPRSTVLAPTTVVTRQDIDRWQSTSVNDVLRRLP GVDITQNGGSGQLSSIFIRGTNASHVLVLIDGVRLNLAGVSGSADLSQFPIALVQRVEYIRGPRSAVYGS DAIGGVVNIITTRDEPGTEISAGWGSNSYQNYDVSTQQQLGDKTRVTLLGDYAHTHGYDVVAYGNTGTQA QTDNDGFLSKTLYGALEHNFTDAWSGFVRGYGYDNRTNYDAYYSPGSPLLDTRKLYSQSWDAGLRYNGEL IKSQLITSYSHSKDYNYDPHYGRYDSSATLDEMKQYTVQWANNVIVGHGSIGAGVDWQKQTTTPGTGYVE DGYDQRNTGIYLTGLQQVGDFTFEGAARSDDNSQFGRHGTWQTSAGWEFIEGYRFIASYGTSYKAPNLGQ LYGFYGNPNLDPEKSKQWEGAFEGLTAGVNWRISGYRNDVSDLIDYDDHTLKYYNEGKARIKGVEATANF DTGPLTHTVSYDYVDARNAITDTPLLRRAKQQVKYQLDWQLYDFDWGITYQYLGTRYDKDYSSYPYQTVK MGGVSLWDLAVAYPVTSHLTVRGKIANLFDKDYETVYGYQTAGREYTLSGSYTF",btuB,Cobalamin receptor; Outer membrane cobalamin translocator,614,68408,5.11,">>> Function: transporter activity Function: signal transducer activity Function: receptor activity || >>> Process: vitamin transport Process: cobalamin transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane",Coenzyme transport and metabolism,"PF07715:Plug PF00593:TonB_dep_Rec","",Cell outer membrane,,"","",1-20,"158-165 169-178 184-195 217-227 232-248 263-277 279-296 309-325 328-337 353-369 371-381 385-400 403-417 434-443 449-458 473-490 494-509 517-529 535-550 558-572 585-596 602-614",Essential,1UJW,btuB,"",L14556,"","" 1054,"Propionyl-CoA carboxylase beta chain, mitochondrial",2009-07-22 22:35:01 UTC,2009-08-13 06:39:38 UTC,P05166,ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl-CoA,"",">Propionyl-CoA carboxylase beta chain, mitochondrial MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHKRGKLTARERI SLLLDPGSFVESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQK ICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPAL TDFTFMVKDTSYLFITGPDVVKSVTNEDVTQEELGGAKTHTTMSGVAHRAFENDVDALCNLRDFFNYLPL SSQDPAPVRECHDPSDRLVPELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGR TVGIVGNQPKVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFA EATVPKVTVITRKAYGGAYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKF ANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKVQRPWRKHANIPL",PCCB,PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta,539,58216,7.69,">>> Function: catalytic activity Function: ligase activity || >>> Process: Not Available || >>> Component: Not Available","",PF01039:Carboxyl_trans,HGNC:8654,Mitochondrion matrix,,"","",None,None,Non Essential,"",PCCB,PCCB,M31169,"","" 1055,Biotin--protein ligase,2009-07-22 22:35:02 UTC,2009-08-13 06:39:36 UTC,P50747,"Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase","",">Biotin--protein ligase MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEHVGRDDPKALG EEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESVKFASAENIPDLPYDYSSSLE SVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFHEVRSVLADCVDIDSYILYHLLEDSALRDPW TDNCLLLVIATRESIPEDLYQKFMAYLSQGGKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEV KLSVLSSGCRYQEGPVRLSPGRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDF NLLKSSNFRRYEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSL RFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMRLLDGLMFQTP QEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPFVQHLMSVAVVEAVRSIPEYQ DINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKQHKAELKP LRADYLIARVVTVLEKLIKEFQDKGPNSVLPLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQE GGEVVTVHPDGNSFDMLRNLILPKRR",HLCS,Biotin apo-protein ligase; Biotin--[methylmalonyl-CoA-carboxytransferase] ligase; Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Holocarboxylase synthetase; HCS; Biotin--[methylcrotonoyl-CoA-carboxylase] ligase; Biotin--[acetyl-CoA-carboxylase] ligase,726,80761,5.34,">>> Function: catalytic activity Function: ligase activity Function: ligase activity, forming carbon-nitrogen bonds Function: biotin-protein ligase activity Function: biotin-[acetyl-CoA-carboxylase] ligase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification || >>> Component: Not Available",Coenzyme transport and metabolism,"PF02237:BPL_C PF03099:BPL_LipA_LipB",HGNC:4976,Cytoplasm. Mitochondrion,,"","",None,None,Non Essential,"",HLCS,HLCS,AJ001864,"","" 1056,Sodium-dependent multivitamin transporter,2009-07-22 22:35:02 UTC,2009-08-13 06:39:36 UTC,Q9Y289,"Transports pantothenate, biotin and lipoate in the presence of sodium","",">Sodium-dependent multivitamin transporter MSVGVSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELLMADRKMGCLP VALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKT VRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVM FLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQR YLSSRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMFAYYQEYPMSIQQAQAAPDQFVLYFVMDLLKGLPG LPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQM GPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAFWIGIGSIVTSMGFSMPPSPSNG SSFSLPTNLTVATVTTLMPLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPA TIYPVLPKLLSLLPLSCQKRLHCRSYGQDHLDTGLFPEKPRNGVLGDSRDKEAMALDGTAYQGSSSTCIL QETSL",SLC5A6,Na(+)-dependent multivitamin transporter; Solute carrier family 5 member 6,635,68703,8.32,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane",Amino acid transport and metabolism,PF00474:SSF,HGNC:11041,Membrane,,"","",None,"24-44 68-88 101-121 143-163 176-196 199-219 256-276 297-317 336-356 396-416 428-448 456-476 528-548",Non Essential,"",SLC5A6,SLC5A6,AF081571,"","" 1057,"Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial",2009-07-22 22:35:02 UTC,2009-08-13 06:39:34 UTC,Q9HCC0,ATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA,"",">Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERVEHIKLGGGEK ARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITGIGRVSGVECMIIANDATV KGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIA VVMGSCTAGGAYVPAMADENIIVRKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDD HHALHLTRKVVRNLNYQKKLDVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAF YGDTLVTGFARIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAK DGAKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAANVLATITKDQR AREGKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLVLGLSFSAALNAPIEKTDFGI FRM",MCCC2,MCCase subunit beta; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA carboxylase 2,563,61334,7.75,">>> Function: catalytic activity Function: ligase activity || >>> Process: Not Available || >>> Component: Not Available","",PF01039:Carboxyl_trans,HGNC:6937,Mitochondrion matrix,,"","",None,None,Non Essential,"",MCCC2,MCCC2,AL079298,"","" 1058,Acetyl-CoA carboxylase 2,2009-07-22 22:35:02 UTC,2009-08-13 06:39:54 UTC,O00763,"ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase","",">Acetyl-CoA carboxylase 2 MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPSQEPFPASDNSGETPQRNGEGHTLPKT PSQAEPASHKGPKDAGRRRNSLPPSHQKPPRNPLSSSDAAPSPELQANGTGTQGLEATDTNGLSSSARPQ GQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSVAGSSRESTRKGSRASLGALSLEAYLTTGEA ETRVPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMRSIR RWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAG WGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGK RISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIF LMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGY VSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGV TPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQF GHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPD IMLGVVCGALNVADAMFRTCMTDFLHSLERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIM NGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLTQYTV EDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPSKVHPAEPFTGELP AQQTLPILGEKLHQVFHSVLENLTNVMSGFCLPEPVFSIKLKEWVQKLMMTLRHPSLPLLELQEIMTSVA GRIPAPVEKSVRRVMAQYASNITSVLCQFPSQQIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRS GIRGYMKTVVLDLLRRYLRVEHHFQQAHYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDE LCGPDPSLSDELISILNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCP ENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSS HPNRMTVPISITNPDLLRHSTELFMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDTPLFS EARTSLYSEDDCKSLREEPIHILNVSIQCADHLEDEALVPILRTFVQSKKNILVDYGLRRITFLIAQEKE FPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFDLTAVPCANHKMHLYLGAAKVKEGVEVTDHRF FIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPTVIMDPFKIEES VRYMVMRYGSRLWKLRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSF GNKQGPQHGMLINTPYVTKDLLQAKRFQAQTLGTTYIYDFPEMFRQALFKLWGSPDKYPKDILTYTELVL DSQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDITFRIGSFGPGEDLLYLRASEMARAE GIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGFKYLYLTPQDYTRISSLNSVHCKHIEEGGESR YMITDIIGKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTCRAIGIGAYLVRLGQRVIQVENSHIILT GASALNKVLGREVYTSNNQLGGVQIMHYNGVSHITVPDDFEGVYTILEWLSYMPKDNHSPVPIITPTDPI DREIEFLPSRAPYDPRWMLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVE TRTVEVAVPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAIKDFNREKLPLMIFANWRGFSGGMKDMYDQ VLKFGAYIVDGLRQYKQPILIYIPPYAELRGGSWVVIDATINPLCIEMYADKESRGGVLEPEGTVEIKFR KKDLIKSMRRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLKAREDLLLPIYHQVAVQFADFHDTPGRMLEK GVISDILEWKTARTFLYWRLRRLLLEDQVKQEILQASGELSHVHIQSMLRRWFVETEGAVKAYLWDNNQV VVQWLEQHWQAGDGPRSTIRENITYLKHDSVLKTIRGLVEENPEVAVDCVIYLSQHISPAERAQVVHLLS TMDSPAST",ACACB,ACC-beta; Biotin carboxylase,2458,276558,6.46,">>> Function: ligase activity Function: vitamin binding Function: biotin binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,"PF08326:ACC_central PF02785:Biotin_carb_C PF00364:Biotin_lipoyl PF01039:Carboxyl_trans PF00289:CPSase_L_chain PF02786:CPSase_L_D2",HGNC:85,Intracytoplasmic membrane,,"","",None,None,Non Essential,"",ACACB,ACACB,U34591,"","" 1059,"Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial",2009-07-22 22:35:02 UTC,2009-08-13 06:39:37 UTC,Q96RQ3,ATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA,"",">Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MAAASAVSVLLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNITKVLIANRGEIACRVMRTAKK LGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAE LCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGG GGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQR RHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMI TGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGV RQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIP QHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKN NVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEID IPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYR EGAQANRHTPLVEFEEEESDKRESE",MCCC1,3-methylcrotonyl-CoA carboxylase 1; MCCase subunit alpha; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit,725,80474,7.86,">>> Function: ligase activity Function: vitamin binding Function: biotin binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF02785:Biotin_carb_C PF00364:Biotin_lipoyl PF00289:CPSase_L_chain PF02786:CPSase_L_D2",HGNC:6936,Mitochondrion matrix,,"","",None,None,Non Essential,"",MCCC1,MCCC1,BC004187,"","" 1060,"Pyruvate carboxylase, mitochondrial",2009-07-22 22:35:02 UTC,2009-08-13 06:39:29 UTC,P11498,"Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate","",">Pyruvate carboxylase, mitochondrial MLKFRTVHGGLRLLGIRRTSTAPAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQ DTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIG PSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSY EELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPA AHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIH VAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISP HYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQL RPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVRNH PGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQEL RELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVV EAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHI HTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEG ARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPS SKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGA SLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEV ELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKV IDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE",PC,Pyruvic carboxylase; PCB,1178,129635,6.83,">>> Function: ligase activity, forming carbon-carbon bonds Function: pyruvate carboxylase activity Function: ligase activity Function: vitamin binding Function: biotin binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity || >>> Process: cellular metabolism Process: alcohol metabolism Process: monosaccharide metabolism Process: hexose metabolism Process: glucose metabolism Process: gluconeogenesis Process: physiological process Process: metabolism || >>> Component: cell Component: intracellular Component: cytoplasm","","PF02785:Biotin_carb_C PF00364:Biotin_lipoyl PF00289:CPSase_L_chain PF02786:CPSase_L_D2 PF00682:HMGL-like PF02436:PYC_OADA",HGNC:8636,Mitochondrion matrix,,"","",None,None,Non Essential,"",PC,PC,K02282,"","" 1061,"Propionyl-CoA carboxylase alpha chain, mitochondrial",2009-07-22 22:35:03 UTC,2009-08-13 06:39:38 UTC,P05165,ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl-CoA,"",">Propionyl-CoA carboxylase alpha chain, mitochondrial MLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNEKTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSD VDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIG PDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDD EETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPS IFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIR VAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISIYY DPMISKLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFKGH MLTKSEKNQLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEV DGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVT EDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLLV ELE",PCCA,PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha,703,77355,7.07,">>> Function: ligase activity Function: vitamin binding Function: biotin binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","","PF02785:Biotin_carb_C PF00364:Biotin_lipoyl PF00289:CPSase_L_chain PF02786:CPSase_L_D2",HGNC:8653,Mitochondrion matrix,,"","",None,None,Non Essential,"",PCCA,PCCA,M26121,"","" 1062,Acetyl-CoA carboxylase 1,2009-07-22 22:35:03 UTC,2009-08-13 06:39:27 UTC,Q13085,"Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase","",">Acetyl-CoA carboxylase 1 MDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGISSLQDG LALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRW SYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWG HASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILN VPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMR LAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSA GTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDSPI DFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHC FSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTML GVVCGALHVADVSLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGS CVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDG GHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQ STALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRI PPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIR GHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCG RDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENL QKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPN RGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSP PQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGIRRLTFL VAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHK MHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDC NHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYL DISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLI KLWESMSTQAFLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVI GNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVDPEDPYKGYRY LYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYNEIITISLV TCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFE GVFTVLHWLSYMPKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSF SEIMQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAI KDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSI NPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKE REEFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELT DGQIQAMLRRWFVEVEGTVKAYVWDNNKDLAEWLEKQLTEEDGVHSVIEENIKCISRDYVLKQIRSLVQA NPEVAMDSIIHMTQHISPTQRAEVIRILSTMDSPST",ACACA,ACC-alpha; Biotin carboxylase,2346,265557,6.32,">>> Function: ligase activity Function: vitamin binding Function: biotin binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,"PF08326:ACC_central PF02785:Biotin_carb_C PF00364:Biotin_lipoyl PF01039:Carboxyl_trans PF00289:CPSase_L_chain PF02786:CPSase_L_D2",HGNC:84,Cytoplasm,,"","",None,None,Non Essential,"",ACACA,ACACA,AJ564444,"","" 1063,Solute carrier family 23 member 1,2009-07-22 22:35:03 UTC,2009-08-13 06:39:26 UTC,Q9UHI7,"Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate","",">Solute carrier family 23 member 1 MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEAL CVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWS LPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVSLIGLSVFQAAGDRAGSH WGISACSILLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTD PKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPP PPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALF ASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVD QILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSSLKSYDFPIGMGIVKRITFLK YIPICPVFKGFSSSSKDQIAIPEDTPENTETASVCTKV",SLC23A1,Sodium-dependent vitamin C transporter 1; hSVCT1; Na(+)/L-ascorbic acid transporter 1; Yolk sac permease-like molecule 3,598,64816,6.58,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane",Nucleotide transport and metabolism,PF00860:Xan_ur_permease,HGNC:10974,Membrane,,"","",None,"53-73 82-102 104-124 160-180 208-228 251-271 313-333 359-379 403-423 427-447 458-478 491-511",Non Essential,"",SLC23A1,SLC23A1,BC050261,"","" 1064,"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1",2009-07-22 22:35:03 UTC,2009-08-13 06:39:40 UTC,Q02809,Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links,"",">Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 MRPLLLLALLGWLLLAEAKGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGLGEDWNVEKGT SAGGGQKVRLLKKALEKHADKEDLVILFADSYDVLFASGPRELLKKFRQARSQVVFSAEELIYPDRRLET KYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQLFYTKIFLDPEKREQINITLDHRCRIFQNL DGALDEVVLKFEMGHVRARNLAYDTLPVLIHGNGPTKLQLNYLGNYIPRFWTFETGCTVCDEGLRSLKGI GDEALPTVLVGVFIEQPTPFVSLFFQRLLRLHYPQKHMRLFIHNHEQHHKAQVEEFLAQHGSEYQSVKLV GPEVRMANADARNMGADLCRQDRSCTYYFSVDADVALTEPNSLRLLIQQNKNVIAPLMTRHGRLWSNFWG ALSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRGELQSSDLFHHSKLDPDMAFCANIRQQ DVFMFLTNRHTLGHLLSLDSYRTTHLHNDLWEVFSNPEDWKEKYIHQNYTKALAGKLVETPCPDVYWFPI FTEVACDELVEEMEHFGQWSLGNNKDNRIQGGYENVPTIDIHMNQIGFEREWHKFLLEYIAPMTEKLYPG YYTRAQFDLAFVVRYKPDEQPSLMPHHDASTFTINIALNRVGVDYEGGGCRFLRYNCSIRAPRKGWTLMH PGRLTHYHEGLPTTRGTRYIAVSFVDP",PLOD1,Lysyl hydroxylase 1; LH1,727,83551,6.94,">>> Function: procollagen-lysine 5-dioxygenase activity Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: endoplasmic reticulum","",PF03171:2OG-FeII_Oxy,HGNC:9081,Rough endoplasmic reticulum membrane,,"","",1-18,None,Non Essential,"",PLOD1,PLOD1,BC016657,"","" 1065,Hyaluronate lyase,2009-07-22 22:35:03 UTC,2009-08-13 06:39:27 UTC,Q54873,"Cleaves hyaluronate chains at a beta-D-GalNAc- (1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D- glucosamine","",">Hyaluronate lyase MQTKTKKLIVSLSSLVLSGFLLNHYMTIGAEETTTNTIQQSQKEVQYQQRDTKNLVENGDFGQTEDGSSP WTGSKAQGWSAWVDQKNSADASTRVIEAKDGAITISSHEKLRAALHRMVPIEAKKKYKLRFKIKTDNKIG IAKVRIIEESGKDKRLWNSATTSGTKDWQTIEADYSPTLDVDKIKLELFYETGTGTVSFKDIELVEVADQ LSEDSQTDKQLEEKIDLPIGKKHVFSLADYTYKVENPDVASVKNGILEPLKEGTTNVIVSKDGKEVKKIP LKILASVKDAYTDRLDDWNGIIAGNQYYDSKNEQMAKLNQELEGKVADSLSSISSQADRTYLWEKFSNYK TSANLTATYRKLEEMAKQVTNPSSRYYQDETVVRTVRDSMEWMHKHVYNSEKSIVGNWWDYEIGTPRAIN NTLSLMKEYFSDEEIKKYTDVIEKFVPDPEHFRKTTDNPFKALGGNLVDMGRVKVIAGLLRKDDQEISST IRSIEQVFKLVDQGEGFYQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKNPIDKDKMQTMYHWID KSFAPLLVNGELMDMSRGRSISRANSEGHVAAVEVLRGIHRIADMSEGETKQCLQSLVKTIVQSDSYYDV FKNLKTYKDISLMQSLLSDAGVASVPRPSYLSAFNKMDKTAMYNAEKGFGFGLSLFSSRTLNYEHMNKEN KRGWYTSDGMFYLYNGDLSHYSDGYWPTVNPYKMPGTTETDAKRADSDTGKVLPSAFVGTSKLDDANATA TMDFTNWNQTLTAHKSWFMLKDKIAFLGSNIQNTSTDTAATTIDQRKLESGNPYKVYVNDKEASLTEQEK DYPETQSVFLESFDSKKNIGYFFFKKSSISMSKALQKGAWKDINEGQSDKEVENEFLTISQAHKQNRDSY GYMLIPNVDRATFNQMIKELESSLIENNETLQSVYDAKQGVWGIVKYDDSVSTISNQFQVLKRGVYTIRK EGDEYKIAYYNPETQESAPDQEVFKKLEQAAQPQVQNSKEKEKSEEEKNHSDQKNLPQTGEGQSILASLG FLLLGAFYLFRRGKNN","",Hyaluronidase; HYase,1066,120772,5.97,">>> Function: carbon-oxygen lyase activity Function: carbon-oxygen lyase activity, acting on polysaccharides Function: catalytic activity Function: lyase activity || >>> Process: Not Available || >>> Component: extracellular region Component: cell Component: cell surface","","PF02018:CBM_4_9 PF00746:Gram_pos_anchor PF02278:Lyase_8 PF02884:Lyase_8_C PF08124:Lyase_8_N","","Secreted, cell wall",,"","",1-30,None,Essential,1OJO,"","",AE005672,"","" 1066,Xylose isomerase,2009-07-22 22:35:04 UTC,2009-08-13 06:39:31 UTC,P24300,Involved in D-xylose catabolism,"",">Xylose isomerase MNYQPTPEDRFTFGLWTVGWQGRDPFGDATRRALDPVESVRRLAELGAHGVTFHDDDLIPFGSSDSEREE HVKRFRQALDDTGMKVPMATTNLFTHPVFKDGGFTANDRDVRRYALRKTIRNIDLAVELGAETYVAWGGR EGAESGGAKDVRDALDRMKEAFDLLGEYVTSQGYDIRFAIEPKPNEPRGDILLPTVGHALAFIERLERPE LYGVNPEVGHEQMAGLNFPHGIAQALWAGKLFHIDLNGQNGIKYDQDLRFGAGDLRAAFWLVDLLESAGY SGPRHFDFKPPRTEDFDGVWASAAGCMRNYLILKERAAAFRADPEVQEALRASRLDELARPTAADGLQAL LDDRSAFEEFDVDAAAARGMAFERLDQLAMDHLLGARG",xylA,"",388,43228,4.78,">>> Function: catalytic activity Function: isomerase activity Function: intramolecular oxidoreductase activity Function: intramolecular oxidoreductase activity, interconverting aldoses and ketoses Function: xylose isomerase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF01261:AP_endonuc_2,"",Cytoplasm,,"","",None,None,Essential,1MNZ,xylA,"",M73789,"","" 1067,"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2",2009-07-22 22:35:04 UTC,2009-08-13 06:39:56 UTC,O00469,Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links,"",">Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 MGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLG QGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAA DGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKREAINI TLDHKCKIFQTLNGAVDEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQDNGCT LCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLTLDYPKEALKLFIHNKEVYHEKDIKVFFDKA KHEIKTIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTR HGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGVWNVPYMANVYLIKGKTLRSEMNERNYFVRDKLDPD MALCRNAREMGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDWKEKYINRDYSKIFTENIVEQ PCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQVDLENVWLHFIREFI APVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIE SPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP",PLOD2,Lysyl hydroxylase 2; LH2,737,84686,6.69,">>> Function: procollagen-lysine 5-dioxygenase activity Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: endoplasmic reticulum","",PF03171:2OG-FeII_Oxy,HGNC:9082,Rough endoplasmic reticulum membrane,,"","",1-25,None,Non Essential,"",PLOD2,PLOD2,BC037169,"","" 1068,"Phytanoyl-CoA dioxygenase, peroxisomal",2009-07-22 22:35:04 UTC,2009-08-13 06:39:38 UTC,O14832,Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA,"",">Phytanoyl-CoA dioxygenase, peroxisomal MEQLRAAARLQIVLGHLGRPSAGAVVAHPTSGTISSASFHPQQFQYTLDNNVLTLEQRKFYEENGFLVIK NLVPDADIQRFRNEFEKICRKEVKPLGLTVMRDVTISKSEYAPSEKMITKVQDFQEDKELFRYCTLPEIL KYVECFTGPNIMAMHTMLINKPPDSGKKTSRHPLHQDLHYFPFRPSDLIVCAWTAMEHISRNNGCLVVLP GTHKGSLKPHDYPKWEGGVNKMFHGIQDYEENKARVHLVMEKGDTVFFHPLLIHGSGQNKTQGFRKAISC HFASADCHYIDVKGTSQENIEKEVVGIAHKFFGAENSVNLKDIWMFRARLVKGERTNL",PHYH,Phytanoyl-CoA alpha-hydroxylase; PhyH; Phytanic acid oxidase,338,38539,8.65,"","",PF05721:PhyH,HGNC:8940,Peroxisome,,"","",None,None,Non Essential,"",PHYH,PHYH,BC029512,"","" 1069,"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3",2009-07-22 22:35:04 UTC,2009-08-13 06:39:43 UTC,O60568,Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links,"",">Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLG LGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSA ESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSL NLDHKSRIFQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCG FCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQL QDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSR HGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPD MAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVE QPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTY VGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVI SSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP",PLOD3,Lysyl hydroxylase 3; LH3,738,84786,5.95,">>> Function: procollagen-lysine 5-dioxygenase activity Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: endoplasmic reticulum","",PF03171:2OG-FeII_Oxy,HGNC:9083,Rough endoplasmic reticulum membrane,,"","",1-24,None,Non Essential,"",PLOD3,PLOD3,BC011674,"","" 1070,Gamma-butyrobetaine dioxygenase,2009-07-22 22:35:04 UTC,2009-08-13 06:39:42 UTC,O75936,Catalyzes the formation of L-carnitine from gamma- butyrobetaine,"",">Gamma-butyrobetaine dioxygenase MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFD RKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKW LSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHH PPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIEL DDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRR SYEAGTEISRHLEGAYADWDVVMSRLRILRQRVENGN",BBOX1,"Gamma-butyrobetaine,2-oxoglutarate dioxygenase; Gamma-butyrobetaine hydroxylase; Gamma-BBH",387,44715,6.73,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02668:TauD,HGNC:964,Cytoplasm,,"","",None,None,Non Essential,"",BBOX1,BBOX1,BC011034,"","" 1071,Peptidyl-glycine alpha-amidating monooxygenase,2009-07-22 22:35:05 UTC,2009-08-13 06:39:46 UTC,P19021,Bifunctional enzyme that catalyzes 2 sequencial steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity,"",">Peptidyl-glycine alpha-amidating monooxygenase MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALDIRMPGVTPKQ SDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNA PPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIP AGEKVVNSDISCHYKNYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSF GDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIP VKSDMVMMHEHHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESES DLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEP EHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTIL VIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHF CQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCV ADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIID IFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMEN KPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEHKLETSSGRVL GRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEEYSAPLPALAPSSS",PAM,PAM; Peptidylglycine alpha-hydroxylating monooxygenase; PHM; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Peptidylamidoglycolate lyase; PAL,973,108333,6.39,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen Function: peptidylglycine monooxygenase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: copper ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: peptide metabolism || >>> Component: cell Component: membrane","","PF03712:Cu2_monoox_C PF01082:Cu2_monooxygen PF01436:NHL",HGNC:8596,Isoform 4:Secreted,,"","",1-20,864-887,Non Essential,1SDW,PAM,PAM,BC018127,"","" 1072,Prolyl 3-hydroxylase 1,2009-07-22 22:35:05 UTC,2009-08-13 06:39:54 UTC,Q32P28,"Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts","",">Prolyl 3-hydroxylase 1 MAVRALKLLTTLLAVVAAASQAEVESEAGWGMVTPDLLFAEGTAAYARGDWPGVVLSMERALRSRAALRA LRLRCRTQCAADFPWELDPDWSPSPAQASGAAALRDLSFFGGLLRRAACLRRCLGPPAAHSLSEEMELEF RKRSPYNYLQVAYFKINKLEKAVAAAHTFFVGNPEHMEMQQNLDYYQTMSGVKEADFKDLETQPHMQEFR LGVRLYSEEQPQEAVPHLEAALQEYFVAYEECRALCEGPYDYDGYNYLEYNADLFQAITDHYIQVLNCKQ NCVTELASHPSREKPFEDFLPSHYNYLQFAYYNIGNYTQAVECAKTYLLFFPNDEVMNQNLAYYAAMLGE EHTRSIGPRESAKEYRQRSLLEKELLFFAYDVFGIPFVDPDSWTPEEVIPKRLQEKQKSERETAVRISQE IGNLMKEIETLVEEKTKESLDVSRLTREGGPLLYEGISLTMNSKLLNGSQRVVMDGVISDHECQELQRLT NVAATSGDGYRGQTSPHTPNEKFYGVTVFKALKLGQEGKVPLQSAHLYYNVTEKVRRIMESYFRLDTPLY FSYSHLVCRTAIEEVQAERKDDSHPVHVDNCILNAETLVCVKEPPAYTFRDYSAILYLNGDFDGGNFYFT ELDAKTVTAEVQPQCGRAVGFSSGTENPHGVKAVTRGQRCAIALWFTLDPRHSERDRVQADDLVKMLFSP EEMDLSQEQPLDAQQGPPEPAQESLSGSESKPKDEL",LEPRE1,Leucine- and proline-enriched proteoglycan 1; Leprecan-1; Growth suppressor 1,736,83395,4.79,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","",PF03171:2OG-FeII_Oxy,HGNC:19316,"Endoplasmic reticulum (By similarity). Secreted, extracellular space, extracellular matrix (By similarity)",,"","",1-22,None,Non Essential,"",LEPRE1,LEPRE1,BT007039,"","" 1073,Hypothetical protein DKFZp686H15154,2009-07-22 22:35:05 UTC,2009-08-13 06:39:40 UTC,Q6N063,"","",">2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 MATVGAPRHFCRCACFCTDNLYVARYGLHVRFRGEQQLRRDYGPILRSRGCVSAKDFQQLLAELEQEVER RQRLGQESAARKALIASSYHPARPEVYDSLQDAALAPEFLAVTEYSVSPDADLKGLLQRLETVSEEKRIY RVPVFTAPFCQALLEELEHFEQSDMPKGRPNTMNNYGVLLHELGLDEPLMTPLRERFLQPLMALLYPDCG GGRLDSHRAFVVKYAPGQDLELGCHYDNAELTLNVALGKVFTGGALYFGGLFQAPTALTEPLEVEHVVGQ GVLHRGGQLHGARPLGTGERWNLVVWLRASAVRNSLCPMCCREPDLVDDEGFGDGFTREEPATVDVCALT",OGFOD2,"",350,38997,5.44,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","",PF03171:2OG-FeII_Oxy,HGNC:25823,"",,"","",None,None,Non Essential,"",OGFOD2,OGFOD2,BC105637,"","" 1074,Prolyl 3-hydroxylase 2,2009-07-22 22:35:05 UTC,2009-08-13 06:39:45 UTC,Q8IVL5,"Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V (By similarity)","",">Prolyl 3-hydroxylase 2 MRERIWAPPLLLLLPLLLPPPLWGGPPDSPRRELELEPGPLQPFDLLYASGAAAYYSGDYERAVRDLEAA LRSHRRLREIRTRCARHCAARHPLPPPPPGEGPGAELPLFRSLLGRARCYRSCETQRLGGPASRHRVSED VRSDFQRRVPYNYLQRAYIKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPH MESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQV LVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYE SLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGA EVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVG DGYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMV CRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTV TASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILDQEQQGKHEL NINPKDEL",LEPREL1,Leprecan-like protein 1; Myxoid liposarcoma-associated protein 4,708,80985,5.47,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","","PF03171:2OG-FeII_Oxy PF07719:TPR_2",HGNC:19317,Endoplasmic reticulum. Golgi apparatus,,"","",1-24,None,Non Essential,"",LEPREL1,LEPREL1,BC005029,"","" 1075,Prolyl 3-hydroxylase 3,2009-07-22 22:35:05 UTC,2009-08-13 06:39:57 UTC,Q8IVL6,"Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V (By similarity)","",">Prolyl 3-hydroxylase 3 MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSQAAL GRVRLDCGASCAADPGAALPAVLLGAPEPDSGPGPTQGSWERQLLRAALRRADCLTQCAARRLGPGGAAR LRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPMHLQMREDMAKYRRMSGVRPQSFRD LETPPHWAAYDTGLELLGRQEAGLALPRLEEALQGSLAQMESCRADCEGPEEQQGAEEEEDGAASQGGLY EAIAGHWIQVLQCRQRCVGETATRPGRSFPVPDFLPNQLRRLHEAHAQVGNLSQAIENVLSVLLFYPEDE AAKRALNQYQAQLGEPRPGLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDPWTPAALIPEALREK LREDQEKRPWDHEPVKPKPLTYWKDVLLLEGVTLTQDSRQLNGSERAVLDGLLTPAECGVLLQLAKDAAG AGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGTVGSQGAKLLLEVSERVRTLTQAYFSPERPLHLSF THLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPN ALTVTARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEE EEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREEL",LEPREL2,Leprecan-like protein 2; Protein B,736,81837,6.26,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","",PF03171:2OG-FeII_Oxy,HGNC:19318,Endoplasmic reticulum (By similarity),,"","",1-20,None,Non Essential,"",LEPREL2,LEPREL2,BC080630,"","" 1076,2-oxoglutarate and iron-dependent oxygenase domain containing 1,2009-07-22 22:35:05 UTC,2009-08-13 06:39:33 UTC,Q8N543,"","",">2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 MNGKRPAEPGPARVGKKGKKEVMAEFSDAVTEETLKKQVAEAWSRRTPFSHEVIVMDMDPFLHCVIPNFI QSQDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKKRREPHISTLRKILFEDFRSWLSDISKIDLESTID MSCAKYEFTDALLCHDDELEGRRIAFILYLVPPWDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFF EVSPVSFHQVSEVLSEEKSRLSISGWFHGPSLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQ VQIQEEFEESSEILLKEFLKPEKFTKVCEALEHGHVEWSSRGPPNKRFYEKAEESKLPEILKECMKLFRS EALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPE PEENETKKESSVPMCQGELRHWKTGHYTLIHDHSKAEFALDLILYCGCEGWEPEYGGFTSYIAKGEDEEL LTVNPESNSLALVYRDRETLKFVKHINHRSLEQKKTFPNRTGFWDFSFIYYE",OGFOD1,Termination and polyadenylation 1 homolog,542,63247,4.77,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism || >>> Component: Not Available","",PF03171:2OG-FeII_Oxy,HGNC:25585,"",,"","",None,None,Non Essential,"",OGFOD1,OGFOD1,BC032919,"","" 1077,Jumonji/ARID domain-containing protein 1D,2009-07-22 22:35:06 UTC,2009-08-13 06:39:45 UTC,Q9BY66,"Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis","",">Histone demethylase JARID1D MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQ RLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWARVAQR LHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYS RRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGN VSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPE IPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVS SIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVP WLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTL MNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYC VFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKC KTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVA LEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTEL RVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQ QVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHFCLEA RQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPV GLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELL GLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCD LCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLP EGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPIREGSGNN ISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDEN HSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSS GIMSQVGREEEHYQEKADRENMFLTPSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL",JARID1D,Jumonji/ARID domain-containing protein 1D; Protein SmcY; Histocompatibility Y antigen; H-Y,1539,174075,5.66,">>> Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: protein binding Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: cell Component: intracellular","","PF01388:ARID PF02373:JmjC PF02375:JmjN PF00628:PHD PF08429:PLU-1 PF02928:zf-C5HC2",HGNC:11115,Nucleus (Probable),,"","",None,None,Non Essential,"",JARID1D,KDM5D,AF134849,"","" 1078,"Trimethyllysine dioxygenase, mitochondrial",2009-07-22 22:35:06 UTC,2009-08-13 06:39:37 UTC,Q9NVH6,Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML),"",">Trimethyllysine dioxygenase, mitochondrial MWYHRLSHLHSRLQDLLKGGVIYPALPQPNFKSLLPLAVHWHHTASKSLTCAWQQHEDHFELKYANTVMR FDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTWPDGHVTKYDLNWLVKNSYEG QKQKVIQPRILWNAEIYQQAQVPSVDCQSFLETNEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLAERIS LIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQ VLQKAPEEFELLSKVPLKHEYIEDVGECHNHMIGIGPVLNIYPWNKELYLIRYNNYDRAVINTVPYDVVH RWYTAHRTLTIELRRPENEFWVKLKPGRVLFIDNWRVLHGRECFTGYRQLCGCYLTRDDVLNTARLLGLQ A",TMLHE,Epsilon-trimethyllysine 2-oxoglutarate dioxygenase; TML-alpha-ketoglutarate dioxygenase; TML dioxygenase; TMLD; TML hydroxylase,421,49518,7.79,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF02668:TauD,HGNC:18308,Mitochondrion matrix (By similarity),,"","",None,None,Non Essential,"",TMLHE,TMLHE,BC025269,"","" 1079,Myrosinase MA1,2009-07-22 22:35:07 UTC,2009-08-13 06:39:52 UTC,P29736,"Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products:thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones","",">Myrosinase MA1 DEEITCQENLPFTCGNTDALNSSSFSSDFIFGVASSAYQIEGTIGRGLNIWDGFTHRYPNKSGPDHGNGD TTCDSFSYWQKDIDVLDELNATGYRFSIAWSRIIPRGKRSRGVNEKGIDYYHGLISGLIKKGITPFVTLF HWDLPQTLQDEYEGFLDPQIIDDFKDYADLCFEEFGDSVKYWLTINQLYSVPTRGYGSALDAPGRCSPTV DPSCYAGNSSTEPYIVAHHQLLAHAKVVDLYRKNYTHQGGKIGPTMITRWFLPYNDTDRHSIAATERMKE FFLGWFMGPLTNGTYPQIMIDTVGERLPSFSPEESNLVKGSYDFLGLNYYFTQYAQPSPNPVNSTNHTAM MDAGAKLTYINASGHYIGPLFEKDKADSTDNIYYYPKGIYSVMDYFKNKYYNPLIYVTENGISTPGDENR NQSMLDYTRIDYLCSHLCFLNKVIKEKDVNVKGYLAWALGDNYEFNKGFTVRFGLSYIDWNNVTDRDLKK SGQWYQSFISP","",Sinigrinase; Thioglucosidase,501,57023,5.08,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on glycosyl bonds Function: hydrolase activity, hydrolyzing O-glycosyl compounds || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00232:Glyco_hydro_1,"",Vacuole,,"","",None,None,Essential,1E71,"","",X59878,"","" 1080,Ascorbate peroxidase,2009-07-22 22:35:07 UTC,2009-07-22 22:35:07 UTC,Q43758,,,,,,,,,,,,,,,,,,,,,,,,, 1081,"25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial",2009-07-22 22:35:07 UTC,2009-08-13 06:39:37 UTC,O15528,"Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation","",">25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSRLHELQVQGAA HFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSL LAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCL EAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNG GQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAA LSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPK TRTVLVPERSINLQFLDR",CYP27B1,Cytochrome P450 subfamily XXVIIB polypeptide 1; Cytochrome p450 27B1; Calcidiol 1-monooxygenase; 25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; VD3 1A hydroxylase; P450C1 alpha; P450VD1-alpha,508,56505,9.39,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2606,Mitochondrion membrane,,"","",None,None,Non Essential,"",CYP27B1,CYP27B1,AY288916,"","" 1082,Vitamin D3 receptor,2009-07-22 22:35:07 UTC,2009-08-13 06:39:29 UTC,P11473,Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Plays a central role in calcium homeostasis,"",">Vitamin D3 receptor MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITK DNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHH KTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEE DSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFT MDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAA LIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE VFGNEIS",VDR,"VDR; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1",427,48290,6.50,">>> Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:12679,Nucleus,,"","",None,None,Non Essential,"",VDR,VDR,M65208,"","" 1083,Flavin reductase,2009-07-22 22:35:07 UTC,2009-08-13 06:39:40 UTC,P30043,"Catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. Possible role in protecting cells from oxidative damage or in regulating iron metabolism. In the liver, converts biliverdin to bilirubin","",">Flavin reductase MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDA VIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLR ESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ",BLVRB,FR; NADPH-dependent diaphorase; NADPH-flavin reductase; FLR; Biliverdin reductase B; BVR-B; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP,206,22120,7.76,">>> Function: binding Function: cofactor binding Function: coenzyme binding Function: NAD binding Function: catalytic activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide-sugar metabolism || >>> Component: Not Available",Cell wall/membrane/envelope biogenesis,PF01370:Epimerase,HGNC:1063,Cytoplasm (Potential),,"","",None,None,Non Essential,1HE5,BLVRB,BLVRB,BC109371,"","" 1084,Riboflavin kinase,2009-07-22 22:35:08 UTC,2009-08-13 06:39:38 UTC,Q969G6,Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN),"",">Riboflavin kinase MRHLPYFCRGQVVRGFGRGSKQLGIPTANFPEQVVDNLPADISTGIYYGWASVGSGDVHKMVVSIGWNPY YKNTKKSMETHIMHTFKEDFYGEILNVAIVGYLRPEKNFDSLESLISAIQGDIEEAKKRLELPEHLKIKE DNFFQVSKSKIMNGH",RFK,ATP:riboflavin 5'-phosphotransferase; Flavokinase,155,17623,8.43,"",Coenzyme transport and metabolism,PF01687:Flavokinase,HGNC:30324,Cytoplasm (By similarity),,"","",None,None,Non Essential,1Q9S,RFK,RFK,AL391868,"","" 1085,Riboflavin kinase/FMN adenylyltransferase,2009-07-22 22:35:08 UTC,2009-08-13 06:39:53 UTC,Q9WZW1,"","",">Riboflavin kinase/FMN adenylyltransferase MVVSIGVFDGVHIGHQKVLRTMKEIAFFRKDDSLIYTISYPPEYFLPDFPGLLMTVESRVEMLSRYARTV VLDFFRIKDLTPEGFVERYLSGVSAVVVGRDFRFGKNASGNASFLRKKGVEVYEIEDVVVQGKRVSSSLI RNLVQEGRVEEIPAYLGRYFEIEGIVHKDREFGRKLGFPTANIDRGNEKLVDLKRGVYLVRVHLPDGKKK FGVMNVGFRPTVGDARNVKYEVYILDFEGDLYGQRLKLEVLKFMRDEKKFDSIEELKAAIDQDVKSARNM IDDIINSKFEKEG","","",293,33614,9.26,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: riboflavin kinase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: vitamin metabolism Process: water-soluble vitamin metabolism Process: riboflavin and derivative metabolism Process: riboflavin metabolism Process: riboflavin biosynthesis || >>> Component: Not Available",Lipid transport and metabolism,"PF06574:FAD_syn PF01687:Flavokinase","","",,"","",None,None,Essential,1T6Z,"","",AE000512,"","" 1086,"6,7-dimethyl-8-ribityllumazine synthase",2009-07-22 22:35:08 UTC,2009-08-13 06:39:37 UTC,Q9UUB1,"Condensation of 5-amino-6-(1'-D)-ribityl-amino- 2,4(1H,3H)-pyrimidinedione with L-3,4-dihydroxy-2-butanone 4- phosphate to produce 6,7-dimethyl-8-(1-D-ribityl)lumazine","",">6,7-dimethyl-8-ribityllumazine synthase MFSGIKGPNPSDLKGPELRILIVHARWNLQAIEPLVKGAVETMIEKHDVKLENIDIESVPGSWELPQGIR ASIARNTYDAVIGIGVLIKGSTMHFEYISEAVVHGLMRVGLDSGVPVILGLLTVLNEEQALYRAGLNGGH NHGNDWGSAAVEMGLKALY",rib4,DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain,159,17188,5.91,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: riboflavin synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: vitamin metabolism Process: water-soluble vitamin metabolism Process: riboflavin and derivative metabolism Process: riboflavin metabolism Process: riboflavin biosynthesis || >>> Component: protein complex Component: unlocalized protein complex Component: riboflavin synthase complex",Coenzyme transport and metabolism,PF00885:DMRL_synthase,"","",,"","",None,None,Essential,1KYY,rib4,"",CU329671,"","" 1087,Vng1446h,2009-07-22 22:35:08 UTC,2009-08-13 06:39:39 UTC,Q9HPW4,"","",">Putative uncharacterized protein MPAPAECCHMVFKKVLLTGTSEESFTAAADDAIDRAEDTLDNVVWAEVVDQGVEIGAVEERTYQTEVQVA FELDGSQ","","",77,8378,3.69,"","",PF07311:DUF1458,"","",,"","",None,None,Essential,1MOG,"","",AE004437,"","" 1088,Flavodoxin,2009-07-22 22:35:08 UTC,2009-08-13 06:39:42 UTC,P00323,Low-potential electron donor to a number of redox enzymes,"",">Flavodoxin MPKALIVYGSTTGNTEYTAETIARELADAGYEVDSRDAASVEAGGLFEGFDLVLLGCSTWGDDSIELQDD FIPLFDSLEETGAQGRKVACFGCGDSSYEYFCGAVDAIEEKLKNLGAEIVQDGLRIDGDPRAARDDIVGW AHDVRGAI","","",148,15823,3.83,">>> Function: catalytic activity Function: oxidoreductase activity Function: transporter activity Function: electron transporter activity Function: binding Function: nucleotide binding Function: FMN binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,PF00258:Flavodoxin_1,"","",,"","",None,None,Essential,1BU5,"","",AE017285,"","" 1089,Riboflavin synthase alpha chain,2009-07-22 22:35:08 UTC,2009-08-13 06:39:28 UTC,P0AFU8,"Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)- pyrimidinedione","",">Riboflavin synthase alpha chain MFTGIVQGTAKLVSIDEKPNFRTHVVELPDHMLDGLETGASVAHNGCCLTVTEINGNHVSFDLMKETLRI TNLGDLKVGDWVNVERAAKFSDEIGGHLMSGHIMTTAEVAKILTSENNRQIWFKVQDSQLMKYILYKGFI GIDGISLTVGEVTPTRFCVHLIPETLERTTLGKKKLGARVNIEIDPQTQAVVDTVERVLAARENAMNQPG TEA",ribE,"",213,23445,5.88,"",Coenzyme transport and metabolism,PF00677:Lum_binding,"","",,"","",None,None,Essential,1I8D,ribE,"",AP009048,"","" 1090,Pyridoxal kinase,2009-07-22 22:35:09 UTC,2009-08-13 06:39:43 UTC,O00764,Required for synthesis of pyridoxal-5-phosphate from vitamin B6,"",">Pyridoxal kinase MEEECRVLSIQSHVIRGYVGNRAATFPLQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSDELQELYEGLR LNNMNKYDYVLTGYTRDKSFLAMVVDIVQELKQQNPRLVYVCDPVLGDKWDGEGSMYVPEDLLPVYKEKV VPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGPDTVVITSSDLPSPQGSNYLIVLGSQRRRNP AGSVVMERIRMDIRKVDAVFVGTGDLFAAMLLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQAGE GVRPSPMQLELRMVQSKRDIEDPEIVVQATVL",PDXK,Pyridoxine kinase,312,35103,6.05,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: pyridoxal kinase activity || >>> Process: Not Available || >>> Component: Not Available",Coenzyme transport and metabolism,PF00294:PfkB,HGNC:8819,Cytoplasm,,"","",None,None,Non Essential,1RFV,PDXK,PDXK,BC005825,"","" 1091,Thiamin pyrophosphokinase 1,2009-07-22 22:35:09 UTC,2009-08-13 06:39:58 UTC,Q9H3S4,Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate,"",">Thiamin pyrophosphokinase 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFING DFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVN TLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLA FGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS",TPK1,Thiamine pyrophosphokinase 1; hTPK1; Placental protein 20; PP20,243,27266,4.82,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: thiamin diphosphokinase activity || >>> Process: cofactor metabolism Process: coenzyme metabolism Process: coenzyme biosynthesis Process: thiamin diphosphate biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: vitamin metabolism Process: water-soluble vitamin metabolism Process: thiamin and derivative metabolism Process: thiamin metabolism || >>> Component: Not Available",Coenzyme transport and metabolism,"PF04265:TPK_B1_binding PF04263:TPK_catalytic",HGNC:17358,"",,"","",None,None,Non Essential,1IG3,TPK1,TPK1,BC014552,"","" 1092,Thiamine transporter 2,2009-07-22 22:35:09 UTC,2009-08-13 06:39:27 UTC,Q9BZV2,"Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport activity","",">Thiamine transporter 2 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPV FVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVS GYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKS SSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFY WSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALV VFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTI MTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNI IMSTKL",SLC19A3,ThTr-2; ThTr2; Solute carrier family 19 member 3,496,55665,6.36,">>> Function: transporter activity Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: reduced folate carrier activity Function: binding Function: vitamin binding Function: folic acid binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane","",PF01770:Folate_carrier,HGNC:16266,Membrane,,"","",None,"8-28 54-74 82-102 111-131 145-165 170-190 283-303 317-337 343-363 376-396 406-426 435-455",Non Essential,"",SLC19A3,SLC19A3,BC032014,"","" 1093,Thiamine transporter 1,2009-07-22 22:35:09 UTC,2009-08-13 06:39:32 UTC,O60779,High-affinity transporter for the intake of thiamine,"",">Thiamine transporter 1 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVF NEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIA YYSYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPM PQKSLFFHHIPSTCQRVNGIKVQNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLK VLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFA VGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERY ALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQS SSQVTTS",SLC19A2,ThTr-1; ThTr1; Thiamine carrier 1; TC1; Solute carrier family 19 member 2,497,55401,6.72,">>> Function: transporter activity Function: carrier activity Function: electrochemical potential-driven transporter activity Function: porter activity Function: reduced folate carrier activity Function: binding Function: vitamin binding Function: folic acid binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane","",PF01770:Folate_carrier,HGNC:10938,Membrane,,"","",None,"29-46 73-91 100-118 129-149 166-185 192-208 286-310 338-354 364-380 387-409 420-443 456-479",Non Essential,"",SLC19A2,SLC19A2,AL021068,"","" 1094,Cytochrome P450 2R1,2009-07-22 22:35:10 UTC,2009-08-13 06:39:34 UTC,Q6VVX0,"Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3)","",">Vitamin D 25-hydroxylase MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQS QVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLA VNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHM IELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAY LDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQ PQPYLICAERR",CYP2R1,Cytochrome P450 2R1,501,57360,7.67,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:20580,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP2R1,CYP2R1,AY800276,"","" 1095,Gamma-glutamyl hydrolase,2009-07-22 22:35:10 UTC,2009-08-13 06:39:53 UTC,Q92820,Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates,"",">Gamma-glutamyl hydrolase MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGAR VVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEEL SLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKL KKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEAR KNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD",GGH,Gamma-Glu-X carboxypeptidase; Conjugase; GH,318,35965,7.14,">>> Function: catalytic activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: glutamine family amino acid metabolism Process: glutamine metabolism || >>> Component: Not Available","",PF07722:Peptidase_C26,HGNC:4248,"Secreted, extracellular space. Lysosome. Melanosome",,"","",1-24,None,Non Essential,1L9X,GGH,GGH,BC025025,"","" 1096,Mitochondrial folate transporter/carrier,2009-07-22 22:35:10 UTC,2009-08-13 06:39:38 UTC,Q9H2D1,Transports folate across the inner membranes of mitochondria,"",">Mitochondrial folate transporter/carrier MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLT TIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNP LWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGALQFMAYELLKLKY NQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYK GIAPNLIRVTPACCITFVVYENVSHFLLDLREKRK",SLC25A32,Solute carrier family 25 member 32,315,35408,9.79,">>> Function: binding Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: organelle membrane Component: organelle inner membrane Component: mitochondrial inner membrane","",PF00153:Mito_carr,HGNC:29683,Mitochondrion inner membrane,,"","",None,"26-43 89-106 123-143 186-203 227-243 281-300",Non Essential,"",SLC25A32,SLC25A32,BC021893,"","" 1097,Folate receptor gamma,2009-07-22 22:35:10 UTC,2009-08-13 06:39:28 UTC,P41439,Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate,"",">Folate receptor gamma MAWQMMQLLLLALVTAAGSAQPRSARARTDLLNVCMNAKHHKTQPSPEDELYGQCSPWKKNACCTASTSQ ELHKDTSRLYNFNWDHCGKMEPTCKRHFIQDSCLYECSPNLGPWIRQVNQSWRKERILNVPLCKEDCERW WEDCRTSYTCKSNWHKGWNWTSGINECPAGALCSTFESYFPTPAALCEGLWSHSFKVSNYSRGSGRCIQM WFDSAQGNPNEEVAKFYAAAMNAGAPSRGIIDS",FOLR3,FR-gamma; Folate receptor 3,243,27638,7.88,"","",PF03024:Folate_rec,HGNC:3795,Secreted,,"","",1-23,None,Non Essential,"",FOLR3,FOLR3,U08470,"","" 1098,Folate receptor beta,2009-07-22 22:35:10 UTC,2009-08-13 06:39:38 UTC,P14207,Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells,"",">Folate receptor beta MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHK DTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDC HTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDS AQGNPNEEVARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG",FOLR2,"FR-beta; Folate receptor 2; Folate receptor, fetal/placental; Placental folate-binding protein; FBP",255,29280,7.56,"","",PF03024:Folate_rec,HGNC:3793,Cell membrane,,"","",1-16,None,Non Essential,"",FOLR2,FOLR2,J02876,"","" 1099,Heme carrier protein 1,2009-07-22 22:35:11 UTC,2009-08-13 06:39:36 UTC,Q96NT5,Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme,"",">Proton-coupled folate transporter MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRS ADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLH VGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYAN PFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITV HFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFA FATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP",SLC46A1,Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1; G21,459,49771,8.97,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF07690:MFS_1,HGNC:30521,Apical cell membrane,,"","",None,"87-107 115-135 149-169 183-203 211-231 267-287 303-325 337-357 359-379 390-410 423-443",Non Essential,"",SLC46A1,SLC46A1,AL832613,"","" 1100,Retinol dehydrogenase 12,2009-07-22 22:35:11 UTC,2009-08-13 06:39:54 UTC,Q96NR8,Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments,"",">Retinol dehydrogenase 12 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIAC RDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGF ETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLF TRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGK YFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRWE",RDH12,All-trans and 9-cis retinol dehydrogenase,316,35094,10.20,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,PF00106:adh_short,HGNC:19977,"",,"","",None,None,Non Essential,"",RDH12,RDH12,BC025724,"","" 1101,"Retinol-binding protein I, cellular",2009-07-22 22:35:11 UTC,2009-08-13 06:39:43 UTC,P09455,Intracellular transport of retinol,"",">Retinol-binding protein 1 MPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKE FEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKVQ",RBP1,Cellular retinol-binding protein I; CRBP-I; Cellular retinol-binding protein; CRBP,135,15850,4.74,">>> Function: lipid binding Function: binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available","",PF00061:Lipocalin,HGNC:9919,Cytoplasm,,"","",None,None,Non Essential,1CRB,RBP1,RBP1,M36809,"","" 1102,11-cis retinol dehydrogenase,2009-07-22 22:35:11 UTC,2009-08-13 06:39:41 UTC,Q92781,"Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Active in the presence of NAD as cofactor but not in the presence of NADP","",">11-cis retinol dehydrogenase MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQR VASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGP IGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPGFFRT PVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTR YSPGWDAKLLWLPASYLPASLVDAVLTWVLPKPAQAVY",RDH5,11-cis RDH,318,34979,9.70,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,PF00106:adh_short,HGNC:9940,Membrane,,"","",None,None,Non Essential,"",RDH5,RDH5,BC028298,"","" 1103,Retinol dehydrogenase 13,2009-07-22 22:35:11 UTC,2009-08-13 06:39:33 UTC,Q8NBN7,Does not exhibit retinol dehydrogenase (RDH) activity in vitro,"",">Retinol dehydrogenase 13 MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACR DMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFE MQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF TKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEEL ADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGLEAPSVREQPLPR",RDH13,"",331,35933,8.24,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,PF00106:adh_short,HGNC:19978,"",,"","",None,None,Non Essential,"",RDH13,RDH13,AY358473,"","" 1104,Interphotoreceptor retinoid-binding protein,2009-07-22 22:35:11 UTC,2009-08-13 06:39:53 UTC,P10745,IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina,"",">Retinol-binding protein 3 MMREWVLLMSVLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPENLLGMQEAIQQAIKSHEILSISDPQTL ASVLTAGVQSSLNDPRLVISYEPSTPEPPPQVPALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPG QEVLSMMGEFLVAHVWGNLMGTSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIYNRPSNTTTEI WTLPQVLGERYGADKDVVVLTSSQTRGVAEDIAHILKQMRRAIVVGERTGGGALDLRKLRIGESDFFFTV PVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALAILTLRSALPGVVHCLQEVLKDYYTLVDRVPTL LQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPTETPSWPAPDAAAEDSPGVAPELPEDEA IRQALVDSVFQVSVLPGNVGYLRFDSFADASVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVP LLLSYFQGPEAGPVHLFTTYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLG WATLVGEITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALDKAQEVL EFHQSLGALVEGTGHLLEAHYARPEVVGQTSALLRAKLAQGAYRTAVDLESLASQLTADLQEVSGDHRLL VFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLPGQLGYLRFDAMAELETVKAVGPQLVRLVWQ QLVDTAALVIDLRYNPGSYSTAIPLLCSYFFEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDL YILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMSATTGKAWDLA GVEPDITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVADNYASAELGAKMATKLSGLQSRYSRVTSEVA LAEILGADLQMLSGDPHLKAAHIPENAKDRIPGIVPMQIPSPEVFEELIKFSFHTNVLEDNIGYLRFDMF GDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGPTSSIPILCSYFFDEGPPVLLDKIYSRPDDSVS ELWTHAQVVGERYGSKKSMVILTSSVTAGTAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYL TIPTARSVGASDGSSWEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL",RBP3,Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein,1247,135364,4.76,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: serine-type peptidase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis || >>> Component: Not Available",Cell wall/membrane/envelope biogenesis,PF03572:Peptidase_S41,HGNC:9921,"Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix",,"","",1-17,None,Non Essential,"",RBP3,RBP3,X53044,"","" 1105,"Retinol-binding protein III, cellular",2009-07-22 22:35:12 UTC,2009-08-13 06:39:59 UTC,P82980,Intracellular transport of retinol,"",">Retinol-binding protein 5 MPPNLTGYYRFVSQKNMEDYLQALNISLAVRKIALLLKPDKEIEHQGNHMTVRTLSTFRNYTVQFDVGVE FEEDLRSVDGRKCQTIVTWEEEHLVCVQKGEVPNRGWRHWLEGEMLYLELTARDAVCEQVFRKVR",RBP5,Cellular retinol-binding protein III; CRBP-III; HRBPiso,135,15931,6.51,">>> Function: lipid binding Function: binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available","",PF00061:Lipocalin,HGNC:15847,Cytoplasm (By similarity),,"","",None,None,Non Essential,1GGL,RBP5,RBP5,BC029355,"","" 1106,Retinoid-binding protein 7,2009-07-22 22:35:12 UTC,2009-08-13 06:40:00 UTC,Q96R05,Intracellular transport of retinol,"",">Retinoid-binding protein 7 MPADLSGTWTLLSSDNFEGYMLALGIDFATRKIAKLLKPQKVIEQNGDSFTIHTNSSLRNYFVKFKVGEE FDEDNRGLDNRKCKSLVIWDNDRLTCIQKGEKKNRGWTHWIEGDKLHLEMFCEGQVCKQTFQRA",RBP7,Cellular retinoic acid-binding protein 4; CRABP4; CRBP4; Cellular retinoic acid-binding protein IV; CRABP-IV,134,15536,7.96,">>> Function: lipid binding Function: binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available","",PF00061:Lipocalin,HGNC:30316,Cytoplasm (By similarity),,"","",None,None,Non Essential,1LPJ,RBP7,RBP7,BC063013,"","" 1107,Plasma retinol-binding protein,2009-07-22 22:35:12 UTC,2009-08-13 06:39:51 UTC,P02753,"Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli","",">Retinol-binding protein 4 MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQ MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRL LNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL",RBP4,Plasma retinol-binding protein; PRBP; RBP; Contains: RecName: Plasma retinol-binding protein(1-182); Contains: RecName: Plasma retinol-binding protein(1-181); Contains: RecName: Plasma retinol-binding protein(1-179); Contains: RecName: Plasma retinol-binding protein(1-176),201,23010,5.85,">>> Function: isoprenoid binding Function: retinoid binding Function: transporter activity Function: binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available","",PF00061:Lipocalin,HGNC:9922,Secreted,,"","",1-18,None,Non Essential,1JYD,RBP4,RBP4,AF025335,"","" 1108,"Retinol-binding protein II, cellular",2009-07-22 22:35:12 UTC,2009-08-13 06:39:42 UTC,P50120,Intracellular transport of retinol,"",">Retinol-binding protein 2 MTRDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKVIDQDGDNFKTKTTSTFRNYDVDFTVGVE FDEYTKSLDNRHVKALVTWEGDVLVCVQKGEKENRGWKQWIEGDKLYLELTCGDQVCRQVFKKK",RBP2,Cellular retinol-binding protein II; CRBP-II,134,15707,5.04,">>> Function: lipid binding Function: binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available","",PF00061:Lipocalin,HGNC:9920,Cytoplasm,,"","",None,None,Non Essential,1EII,RBP2,RBP2,BC069522,"","" 1109,Cellular retinaldehyde-binding protein,2009-07-22 22:35:12 UTC,2009-08-13 06:39:43 UTC,P12271,Carries 11-cis-retinol and 11-cis-retinaldehyde as endogenous ligands and may be a functional component of the visual cycle,"",">Retinaldehyde-binding protein 1 MSEGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPCSQLPRHTLQKAKDELNEREETREEAVRELQEMV QAQAASGEELAVAVAERVQEKDSGFFLRFIRARKFNVGRAYELLRGYVNFRLQYPELFDSLSPEAVRCTI EAGYPGVLSSRDKYGRVVMLFNIENWQSQEITFDEILQAYCFILEKLLENEETQINGFCIIENFKGFTMQ QAASLRTSDLRKMVDMLQDSFPARFKAIHFIHQPWYFTTTYNVVKPFLKSKLLERVFVHGDDLSGFYQEI DENILPSDFGGTLPKYDGKAVAEQLFGPQAQAENTAF",RLBP1,Cellular retinaldehyde-binding protein,317,36475,4.70,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: intracellular","","PF00650:CRAL_TRIO PF03765:CRAL_TRIO_N",HGNC:10024,Cytoplasm,,"","",None,None,Non Essential,"",RLBP1,RLBP1,BC004199,"","" 1110,Lecithin retinol acyltransferase,2009-07-22 22:35:13 UTC,2009-08-13 06:39:35 UTC,O95237,"Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments","",">Lecithin retinol acyltransferase MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRV AHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEE VARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIVCTG LVSYTTLPAIFIPFFLWMAG",LRAT,Phosphatidylcholine--retinol O-acyltransferase,230,25703,7.54,"","",PF04970:NC,HGNC:6685,Endoplasmic reticulum membrane,,"","",None,206-226,Non Essential,"",LRAT,LRAT,BC031053,"","" 1111,Short-chain dehydrogenase/reductase 3,2009-07-22 22:35:13 UTC,2009-08-13 06:39:54 UTC,O75911,Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH,"",">Short-chain dehydrogenase/reductase 3 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWG RTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDAL LKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCP GVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQA ALEEIHKFSGTYTCMNTFKGRT",DHRS3,Retinal short-chain dehydrogenase/reductase 1; retSDR1; DD83.1,302,33549,9.08,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,PF00106:adh_short,HGNC:17693,Membrane,,"","",None,"9-29 170-190 195-215 253-273",Non Essential,"",DHRS3,DHRS3,BC002730,"","" 1112,"All-trans-retinol 13,14-reductase",2009-07-22 22:35:13 UTC,2009-08-13 06:39:30 UTC,Q6NUM9,"Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity)","",">All-trans-retinol 13,14-reductase MWLPLVLLLAVLLLAVLCKVYLGLFSGSSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFSANQVPEKLDV VVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGCCHTFGKNGLEFDTGIHYIGRMEEGSIGRFILDQIT EGQLDWAPLSSPFDIMVLEGPNGRKEYPMYSGEKAYIQGLKEKFPQEEAIIDKYIKLVKVVSSGAPHAIL LKFLPLPVVQLLDRCGLLTRFSPFLQASTQSLAEVLQQLGASSELQAVLSYIFPTYGVTPNHSAFSMHAL LVNHYMKGGFYPRGGSSEIAFHTIPVIQRAGGAVLTKATVQSVLLDSAGKACGVSVKKGHELVNIYCPIV VSNAGLFNTYEHLLPGNARCLPGVKQQLGTVRPGLGMTSVFICLRGTKEDLHLPSTNYYVYYDTDMDQAM ERYVSMPREEAAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIMLIPTAYEWFEEWQAELKGKRGSDYETFK NSFVEASMSVVLKLFPQLEGKVESVTAGSPLTNQFYLAAPRGACYGADHDLGRLHPCVMASLRAQSPIPN LYLTGQDIFTCGLVGALQGALLCSSAILKRNLYSDLKNLDSRIRAQKKKN",RETSAT,"All-trans-13,14-dihydroretinol saturase; RetSat",610,66820,8.39,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00890:FAD_binding_2,HGNC:25991,Endoplasmic reticulum membrane,,"","",1-18,None,Non Essential,"",RETSAT,RETSAT,BC068517,"","" 1113,Retinol dehydrogenase 11,2009-07-22 22:35:13 UTC,2009-08-13 06:39:38 UTC,Q8TC12,Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected,"",">Retinol dehydrogenase 11 MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYL ACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTAD GFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANI LFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILS GNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGLPID",RDH11,Retinal reductase 1; RalR1; Prostate short-chain dehydrogenase/reductase 1; Androgen-regulated short-chain dehydrogenase/reductase 1; HCV core-binding protein HCBP12,318,35387,9.06,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,PF00106:adh_short,HGNC:17964,Endoplasmic reticulum membrane,,"","",None,1-21,Non Essential,"",RDH11,RDH11,BC051291,"","" 1114,Dehydrogenase/reductase SDR family member 4,2009-07-22 22:35:13 UTC,2009-08-13 06:39:50 UTC,Q9BTZ2,"Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity)","",">Dehydrogenase/reductase SDR family member 4 MASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVC HVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEK RGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKE KEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL",DHRS4,Short-chain dehydrogenase/reductase family member 4; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; PHCR; CR; Peroxisomal short-chain alcohol dehydrogenase; PSCD; NADPH-dependent retinol dehydrogenase/reductase; NRDR; humNRDR; SCAD-SRL,260,27572,7.96,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,PF00106:adh_short,HGNC:16985,Peroxisome,,"","",None,None,Non Essential,"",DHRS4,DHRS4,DQ338571,"","" 1115,Retinol dehydrogenase 14,2009-07-22 22:35:14 UTC,2009-08-13 06:39:36 UTC,Q9HBH5,Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected,"",">Retinol dehydrogenase 14 MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARV IMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLI NNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQS YNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPV EGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK",RDH14,Alcohol dehydrogenase PAN2,336,36865,9.00,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,PF00106:adh_short,HGNC:19979,"",,"","",None,None,Non Essential,"",RDH14,RDH14,BC009830,"","" 1116,Photoreceptor outer segment all-trans retinol dehydrogenase,2009-07-22 22:35:14 UTC,2009-08-13 06:39:57 UTC,Q9NYR8,Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity),"",">Retinol dehydrogenase 8 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDVCSD ESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVI SSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDP ETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRT THRLLFRCPRLLNLGLQCLSCGCLPTRVRPR",RDH8,Photoreceptor outer segment all-trans retinol dehydrogenase,311,33756,8.48,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on CH-OH group of donors Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function: steroid dehydrogenase activity Function: estradiol 17-beta-dehydrogenase activity || >>> Process: physiological process Process: metabolism Process: primary metabolism Process: lipid metabolism Process: cellular lipid metabolism Process: steroid metabolism Process: steroid biosynthesis Process: estrogen biosynthesis || >>> Component: cell Component: intracellular Component: cytoplasm",Lipid transport and metabolism,PF00106:adh_short,HGNC:14423,Membrane,,"","",None,"86-106 137-157 169-189",Non Essential,"",RDH8,RDH8,AK024022,"","" 1117,SEC14-like protein 4,2009-07-22 22:35:14 UTC,2009-08-13 06:39:35 UTC,Q9UDX3,"Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids","",">SEC14-like protein 4 MSSRVGDLSPQQQEALARFRENLQDLLPILPNADDYFLLRWLRARNFDLQKSEDMLRRHMEFRKQQDLDN IVTWQPPEVIQLYDSGGLCGYDYEGCPVYFNIIGSLDPKGLLLSASKQDMIRKRIKVCELLLHECELQTQ KLGRKIEMALMVFDMEGLSLKHLWKPAVEVYQQFFSILEANYPETLKNLIVIRAPKLFPVAFNLVKSFMS EETRRKIVILGDNWKQELTKFISPDQLPVEFGGTMTDPDGNPKCLTKINYGGEVPKSYYLCEQVRLQYEH TRSVGRGSSLQVENEILFPGCVLRWQFASDGGDIGFGVFLKTKMGEQQSAREMTEVLPSQRYNAHMVPED GSLTCLQAGVYVLRFDNTYSRMHAKKLSYTVEVLLPDKASEETLQSLKAMRPSPTQ",SEC14L4,Tocopherol-associated protein 3,406,46644,6.52,">>> Function: carrier activity Function: protein carrier activity Function: transporter activity || >>> Process: protein transport Process: intracellular protein transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: membrane Component: cell Component: intracellular","","PF00650:CRAL_TRIO PF03765:CRAL_TRIO_N PF01105:EMP24_GP25L",HGNC:20627,"",,"","",None,None,Non Essential,"",SEC14L4,SEC14L4,AC004832,"","" 1118,SEC14-like protein 3,2009-07-22 22:35:14 UTC,2009-08-13 06:39:57 UTC,Q9UDX4,"Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids","",">SEC14-like protein 3 MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQKSEALLRKYMEFRKTMDIDH ILDWQPPEVIQKYMPGGLCGYDRDGCPVWYDIIGPLDPKGLLFSVTKQDLLKTKMRDCERILHECDLQTE RLGKKIETIVMIFDCEGLGLKHFWKPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLS EDTRRKIIVLGNNWKEGLLKLISPEELPAQFGGTLTDPDGNPKCLTKINYGGEIPKSMYVRDQVKTQYEH SVQINRGSSHQVEYEILFPGCVLRWQFSSDGADIGFGVFLKTKMGERQRAGEMTDVLPSQRYNAHMVPED GNLTCSEAGVYVLRFDNTYSFVHAKKVSFTVEVLLPDEGMQKYDKELTPV",SEC14L3,Tocopherol-associated protein 2,400,46049,5.97,">>> Function: carrier activity Function: protein carrier activity Function: transporter activity || >>> Process: protein transport Process: intracellular protein transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: membrane Component: cell Component: intracellular","","PF00650:CRAL_TRIO PF03765:CRAL_TRIO_N PF01105:EMP24_GP25L",HGNC:18655,"",,"","",None,None,Non Essential,"",SEC14L3,SEC14L3,AC004832,"","" 1119,SEC14-like protein 2,2009-07-22 22:35:14 UTC,2009-08-13 06:39:50 UTC,O76054,"Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell","",">SEC14-like protein 2 MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDN IISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTT KLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLS EDTRKKIMVLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEH SVQISRGSSHQVEYEILFPGCVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPED GTLTCSDPGIYVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLGAGTPK",SEC14L2,Alpha-tocopherol-associated protein; TAP; hTAP; Supernatant protein factor; SPF; Squalene transfer protein,403,46146,7.94,">>> Function: carrier activity Function: protein carrier activity Function: transporter activity || >>> Process: protein transport Process: intracellular protein transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: membrane Component: cell Component: intracellular","","PF00650:CRAL_TRIO PF03765:CRAL_TRIO_N PF01105:EMP24_GP25L",HGNC:10699,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1OLM,SEC14L2,SEC14L2,AC004832,"","" 1120,Orphan nuclear receptor PXR,2009-07-22 22:35:14 UTC,2009-08-13 06:39:43 UTC,O75469,Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A4 and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics,"",">Nuclear receptor subfamily 1 group I member 2 MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMK RNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGV QGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLK VSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA FELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFS PDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF ATPLMQELFGITGS",NR1I2,Orphan nuclear receptor PXR; Pregnane X receptor; Orphan nuclear receptor PAR1; Steroid and xenobiotic receptor; SXR,434,49762,8.44,">>> Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:7968,Nucleus (By similarity),,"","",None,None,Non Essential,1NRL,NR1I2,NR1I2,BC017304,"","" 1121,Arachidonate 5-lipoxygenase,2009-07-22 22:35:15 UTC,2009-08-13 06:39:55 UTC,P09917,Arachidonate + O(2) = leukotriene A(4) + H(2)O,"",">Arachidonate 5-lipoxygenase MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRI EKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQ KQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEK IFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQG NIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLL AKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECG LFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVV DIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYD WCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKP VKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI",ALOX5,5-lipoxygenase; 5-LO,674,77984,5.54,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Function: lipoxygenase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding || >>> Process: organic acid metabolism Process: carboxylic acid metabolism Process: fatty acid metabolism Process: icosanoid metabolism Process: leukotriene metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","","PF00305:Lipoxygenase PF01477:PLAT",HGNC:435,Cytoplasm. Membrane,,"","",None,None,Non Essential,"",ALOX5,ALOX5,M38191,"","" 1122,Diacylglycerol kinase alpha,2009-07-22 22:35:15 UTC,2009-08-13 06:39:33 UTC,P23743,"Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity","",">Diacylglycerol kinase alpha MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHL SLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIIL QMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWRP KRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESG RCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKT SQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLE MSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFE FATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALG ATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDVE PWMQTPCTIKITHKNQMPMLMGPPPRSTNFFGFLS",DGKA,DAG kinase alpha; Diglyceride kinase alpha; DGK-alpha; 80 kDa diacylglycerol kinase,735,82673,6.71,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: diacylglycerol kinase activity || >>> Process: G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) Process: protein kinase C activation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00609:DAGK_acc PF00781:DAGK_cat PF00036:efhand",HGNC:2849,"",,"","",None,None,Non Essential,1TUZ,DGKA,DGKA,BC031870,"","" 1123,Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform,2009-07-22 22:35:15 UTC,2009-08-13 06:39:39 UTC,P62714,"PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase","",">Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFR IGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNA NVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWG ISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDD TLKYSFLQFDPAPRRGEPHVTRRTPDYFL",PPP2CB,PP2A-beta,309,35575,5.08,">>> Function: catalytic activity Function: hydrolase activity || >>> Process: Not Available || >>> Component: Not Available",Signal transduction mechanisms,PF00149:Metallophos,HGNC:9300,Cytoplasm,,"","",None,None,Non Essential,"",PPP2CB,PPP2CB,M60484,"","" 1124,Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform,2009-07-22 22:35:15 UTC,2009-08-13 06:39:58 UTC,P67775,"PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen","",">Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFR IGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNA NVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWG ISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDD TLKYSFLQFDPAPRRGEPHVTRRTPDYFL",PPP2CA,PP2A-alpha; Replication protein C; RP-C,309,35595,5.22,">>> Function: catalytic activity Function: hydrolase activity || >>> Process: Not Available || >>> Component: Not Available",Signal transduction mechanisms,PF00149:Metallophos,HGNC:9299,Cytoplasm,,"","",None,None,Non Essential,"",PPP2CA,PPP2CA,BC031696,"","" 1125,Alpha-tocopherol transfer protein,2009-07-22 22:35:15 UTC,2009-08-13 06:39:45 UTC,P49638,Binds alpha-tocopherol and enhances its transfer between separate membranes,"",">Alpha-tocopherol transfer protein MAEARSQPSAGPQLNALPDHSPLLQPGLAALRRRAREAGVPLAPLPLTDSFLLRFLRARDFDLDLAWRLL KNYYKWRAECPEISADLHPRSIIGLLKAGYHGVLRSRDPTGSKVLIYRIAHWDPKVFTAYDVFRVSLITS ELIVQEVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMI KPFLTEKIKERIHMHGNNYKQSLLQHFPDILPLEYGGEEFSMEDICQEWTNFIMKSEDYLSSISESIQ",TTPA,Alpha-TTP,278,31750,7.78,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: intracellular","","PF00650:CRAL_TRIO PF03765:CRAL_TRIO_N",HGNC:12404,Cytoplasm,,"","",None,None,Non Essential,1OIZ,TTPA,TTPA,AF031324,"","" 1126,"Lipoyltransferase 1, mitochondrial",2009-07-22 22:35:16 UTC,2009-08-13 06:39:30 UTC,Q9Y234,Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes (By similarity),"",">Lipoyltransferase 1, mitochondrial MLIPFSMKNCFQLLCNCQVPAAGFKKTVKNGLILQSISNDVYQNLAVEDWIHDHMNLEGKPILFFWQNSP SVVIGRHQNPWQECNLNLMREEGIKLARRRSGGGTVYHDMGNINLTFFTTKKKYDRMENLKLIVRALNAV QPQLDVQATKRFDLLLDGQFKISGTASKIGRTTAYHHCTLLCSTDGTFLSSLLKSPYQGIRSNATASIPS LVKNLLEKDPTLTCEVLMNAVATEYAAYHQIDNHIHLINPTDETLFPGINSKAKELQTWEWIYGKTPKFS INTSFHVLYEQSHLEIKVFIDIKNGRIEICNIEAPDHWLPLEIRDKLNSSLIGSKFCPTETTMLTNILLR TCPQDHKLNSKWNILCEKIKGIM",LIPT1,Lipoate-protein ligase; Lipoate biosynthesis protein; Lipoyl ligase,373,42480,8.48,">>> Function: catalytic activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification || >>> Component: Not Available",Carbohydrate transport and metabolism,PF03099:BPL_LipA_LipB,HGNC:29569,Mitochondrion,,"","",None,None,Non Essential,"",LIPT1,LIPT1,BC070145,"","" 1127,"Lipoic acid synthetase, mitochondrial",2009-07-22 22:35:17 UTC,2009-08-13 06:39:52 UTC,O43766,"Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)","",">Lipoyl synthase, mitochondrial MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQK GERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRG CRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVE CLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIML GLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVR SSYKAGEFFLKNLVAKRKTKDL",LIAS,Lipoic acid synthase; Lipoate synthase; Lip-syn; LS,372,41911,8.77,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: ligase activity Function: ligase activity, forming carbon-nitrogen bonds Function: lipoate-protein ligase activity Function: lipoate synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: cofactor metabolism Process: coenzyme metabolism Process: lipoic acid metabolism Process: lipoic acid biosynthesis Process: lipoate biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF04055:Radical_SAM,HGNC:16429,Mitochondrion (By similarity),,"","",None,None,Non Essential,"",LIAS,LIAS,AJ224162,"","" 1128,"Cytochrome P450 27, mitochondrial",2009-07-22 22:35:17 UTC,2009-08-13 06:39:57 UTC,Q02318,"Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity","",">Cytochrome P450 27, mitochondrial MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAPGAGPGVRRRQRSLEEIPRLGQLRFFF QLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQH DLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFY YFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFS FGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYH LSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPK NTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLL ARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC",CYP27A1,"Cytochrome P-450C27/25; Sterol 26-hydroxylase; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase",531,60236,9.16,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2605,Mitochondrion membrane,,"","",None,None,Non Essential,"",CYP27A1,CYP27A1,S62709,"","" 1129,Vitamin D-binding protein,2009-07-22 22:35:17 UTC,2009-08-13 06:39:32 UTC,P02774,"Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes","",">Vitamin D-binding protein MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSL TEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPT NDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLS LLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPE HTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFEL SRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK KLAERLKAKLPDATPKELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL",GC,DBP; VDB; Group-specific component; Gc-globulin,474,52964,5.21,">>> Function: transporter activity Function: carrier activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: extracellular region Component: extracellular space","","PF00273:Serum_albumin PF09164:VitD-bind_III",HGNC:4187,Secreted,,"","",1-16,None,Non Essential,1KXP,GC,GC,S77130,"","" 1130,Vitamin K-dependent protein Z,2009-07-22 22:35:17 UTC,2009-08-13 06:39:35 UTC,P22891,Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles,"",">Vitamin K-dependent protein Z MAGCVPLLQGLVLVLALHRVEPSVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEEARE VFENEVVTDEFWRRYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELAKNECHPERTDGCQHF CLPGQESYTCSCAQGYRLGEDHKQCVPHDQCACGVLTSEKRAPDLQDLPWQVKLTNSEGKDFCGGVIIRE NFVLTTAKCSLLHRNITVKTYFNRTSQDPLMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGAGLPV CTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVAAMH WMDGSVVTREHRGSWFLTGVLGSQPVGGQAHMVLVTKVSRYSLWFKQIMN",PROZ,"",400,44744,5.87,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis Process: physiological process Process: organismal physiological process Process: regulation of body fluids Process: hemostasis Process: blood coagulation || >>> Component: extracellular region","","PF00008:EGF PF00594:Gla PF00089:Trypsin",HGNC:9460,Secreted,,"","",1-23,None,Non Essential,"",PROZ,PROZ,M59303,"","" 1131,Vitamin K epoxide reductase complex subunit 1,2009-07-22 22:35:17 UTC,2009-08-13 06:39:33 UTC,Q9BQB6,"Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K","",">Vitamin K epoxide reductase complex subunit 1 MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVL GQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYA INVSLMWLSFRKVQEPQGKAKRH",VKORC1,"Vitamin K1 2,3-epoxide reductase subunit 1",163,18235,9.58,"","",PF07884:VKOR,HGNC:23663,Endoplasmic reticulum membrane,,"","",None,"9-29 101-123 127-149",Non Essential,"",VKORC1,VKORC1,BC002911,"","" 1132,Coagulation factor IX,2009-07-22 22:35:18 UTC,2009-08-13 06:39:45 UTC,P00740,"Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa","",">Coagulation factor IX MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCS FEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGR CEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETI LDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAG EHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGS GYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT",F9,Christmas factor; Plasma thromboplastin component; PTC; Contains: RecName: Coagulation factor IXa light chain; Contains: RecName: Coagulation factor IXa heavy chain,461,51779,5.16,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis Process: physiological process Process: organismal physiological process Process: regulation of body fluids Process: hemostasis Process: blood coagulation || >>> Component: extracellular region","","PF00008:EGF PF00594:Gla PF00089:Trypsin",HGNC:3551,Secreted,,REACT_604-Hemostasis;,"",1-28,None,Non Essential,1RFN,F9,F9,S66752,"","" 1133,Coagulation factor VII,2009-07-22 22:35:18 UTC,2009-08-13 06:39:36 UTC,P08709,"Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium","",">Coagulation factor VII MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRP GSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRN CETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQ GRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDE QSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDR GATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP",F7,Serum prothrombin conversion accelerator; SPCA; Proconvertin; Eptacog alfa; Contains: RecName: Factor VII light chain; Contains: RecName: Factor VII heavy chain,466,51594,7.23,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis Process: physiological process Process: organismal physiological process Process: regulation of body fluids Process: hemostasis Process: blood coagulation || >>> Component: extracellular region","","PF00008:EGF PF00594:Gla PF00089:Trypsin",HGNC:3544,Secreted,,REACT_604-Hemostasis;,"",1-20,None,Non Essential,1Z6J,F7,F7,AL137002,"","" 1134,Coagulation factor X,2009-07-22 22:35:18 UTC,2009-08-13 06:39:34 UTC,P00742,"Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting","",">Coagulation factor X MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREV FEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFC HEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDP TENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQ AKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAE STLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK",F10,Stuart factor; Stuart-Prower factor; Contains: RecName: Factor X light chain; Contains: RecName: Factor X heavy chain; Contains: RecName: Activated factor Xa heavy chain,488,54732,5.74,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis Process: physiological process Process: organismal physiological process Process: regulation of body fluids Process: hemostasis Process: blood coagulation || >>> Component: extracellular region","","PF00008:EGF PF00594:Gla PF00089:Trypsin",HGNC:3528,Secreted,,REACT_604-Hemostasis;,"",1-31,None,Non Essential,1P0S,F10,F10,M33297,"","" 1135,Vitamin K-dependent gamma-carboxylase,2009-07-22 22:35:18 UTC,2009-08-13 06:39:47 UTC,P38435,Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide,"",">Vitamin K-dependent gamma-carboxylase MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFL FGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCV LFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLNAHRRNAHVPLWNYAVLRGQIFIV YFIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGL FFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRG KSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRT GELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQ AAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEV TVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSE TGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTC ISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF",GGCX,Gamma-glutamyl carboxylase; Vitamin K gamma glutamyl carboxylase,758,87562,8.10,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity Function: gamma-glutamyl carboxylase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: peptidyl-amino acid modification Process: peptidyl-glutamic acid modification Process: peptidyl-glutamic acid carboxylation || >>> Component: Not Available","",PF05090:VKG_Carbox,HGNC:4247,Endoplasmic reticulum membrane,,"","",None,"61-81 114-134 137-157 293-313 362-382",Non Essential,"",GGCX,GGCX,BC013979,"","" 1136,Vitamin K-dependent protein C,2009-07-22 22:35:18 UTC,2009-08-13 06:39:37 UTC,P04070,Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids,"",">Vitamin K-dependent protein C MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAK EIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNC SLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDP RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDL DIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREK EAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP",PROC,Autoprothrombin IIA; Anticoagulant protein C; Blood coagulation factor XIV; Contains: RecName: Vitamin K-dependent protein C light chain; Contains: RecName: Vitamin K-dependent protein C heavy chain; Contains: RecName: Activation peptide,461,52072,6.23,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis Process: physiological process Process: organismal physiological process Process: regulation of body fluids Process: hemostasis Process: blood coagulation || >>> Component: extracellular region","","PF00008:EGF PF00594:Gla PF00089:Trypsin",HGNC:9451,Cytoplasmic,,REACT_604-Hemostasis;,"",1-32,None,Non Essential,1AUT,PROC,PROC,S58668,"","" 1137,Vitamin K-dependent protein S,2009-07-22 22:35:18 UTC,2009-08-13 06:39:43 UTC,P07225,Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis,"",">Vitamin K-dependent protein S MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEARE VFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKAS FTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPS ICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQK SCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWL LIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGL LETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGI AQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIY RIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSAT PVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS",PROS1,"",676,75123,5.37,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: Not Available || >>> Component: extracellular region","","PF00008:EGF PF07645:EGF_CA PF00594:Gla PF00054:Laminin_G_1 PF02210:Laminin_G_2",HGNC:9456,Secreted,,"","",1-24,None,Non Essential,"",PROS1,PROS1,BC015801,"","" 1138,NAD(P)H dehydrogenase [quinone] 1,2009-07-22 22:35:18 UTC,2009-08-13 06:39:33 UTC,P15559,The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis,"",">NAD(P)H dehydrogenase [quinone] 1 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPA ESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRS KKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKK RLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK",NQO1,Quinone reductase 1; NAD(P)H:quinone oxidoreductase 1; QR1; DT-diaphorase; DTD; Azoreductase; Phylloquinone reductase; Menadione reductase,274,30868,9.34,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on NADH or NADPH Function: NAD(P)H dehydrogenase (quinone) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02525:Flavodoxin_2,HGNC:2874,Cytoplasm,,"","",None,None,Non Essential,1KBQ,NQO1,NQO1,BC007659,"","" 1139,Ribosyldihydronicotinamide dehydrogenase [quinone],2009-07-22 22:35:19 UTC,2009-08-13 06:39:26 UTC,P16083,The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis,"",">Ribosyldihydronicotinamide dehydrogenase [quinone] MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGV ETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQG KLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQ RLQTIWKEEPIPCTAHWHFGQ",NQO2,NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; Quinone reductase 2; QR2,231,25953,6.24,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on NADH or NADPH Function: NAD(P)H dehydrogenase (quinone) activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02525:Flavodoxin_2,HGNC:7856,Cytoplasm,,"","",None,None,Non Essential,1SG0,NQO2,NQO2,BC006096,"","" 1140,Vitamin K epoxide reductase complex subunit 1-like protein 1,2009-07-22 22:35:19 UTC,2009-08-13 06:39:57 UTC,Q8N0U8,"","",">Vitamin K epoxide reductase complex subunit 1-like protein 1 MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRWGRGF GLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALILMTSSIMSVVGSLYLAYILYFVLKEFCI ICIVTYVLNFLLLIINYKRLVYLNEAWKRQLQPKQD",VKORC1L1,VKORC1-like protein 1,176,19836,9.35,"","",PF07884:VKOR,HGNC:21492,Membrane,,"","",None,"17-37 92-112 114-134 135-155",Non Essential,"",VKORC1L1,VKORC1L1,CR627471,"","" 1141,Sodium-dependent serotonin transporter,2009-07-22 22:35:19 UTC,2009-08-13 06:39:33 UTC,P31645,Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals,"",">Sodium-dependent serotonin transporter METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTL VAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALG QYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCT NYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKV VWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASY NKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVK LLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSP PQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV",SLC6A4,5HT transporter; 5HTT; Solute carrier family 6 member 4,630,70325,6.17,">>> Function: transporter activity Function: neurotransmitter transporter activity Function: neurotransmitter:sodium symporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: neurotransmitter transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane Component: integral to plasma membrane","","PF03491:5HT_transporter PF00209:SNF",HGNC:11050,Membrane,,"","",None,"88-108 116-135 160-180 253-271 280-297 333-350 362-383 417-436 464-482 498-518 539-558 577-595",Non Essential,"",SLC6A4,SLC6A4,U79746,"","" 1142,Alpha-1A adrenergic receptor,2009-07-22 22:35:19 UTC,2009-08-13 06:39:49 UTC,P35348,This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins,"",">Alpha-1A adrenergic receptor MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAV ADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ RRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVV AKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGC FVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ SSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV",ADRA1A,Alpha 1A-adrenoreceptor; Alpha 1A-adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c,466,51487,9.23,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: adrenoceptor activity Function: alpha-adrenergic receptor activity Function: alpha1-adrenergic receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:277,Cell membrane,,"","",None,"28-51 65-88 100-122 144-167 182-205 274-297 306-329",Non Essential,"",ADRA1A,ADRA1A,AY389505,"","" 1143,Alpha-2A adrenergic receptor,2009-07-22 22:35:20 UTC,2009-08-13 06:39:29 UTC,P08913,"Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol","",">Alpha-2A adrenergic receptor MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNL FLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIE YNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCL IMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEP APAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPG EERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSS LNPVIYTIFNHDFRRAFKKILCRGDRKRIV",ADRA2A,Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR; Alpha-2 adrenergic receptor subtype C10,450,48957,10.20,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: adrenoceptor activity Function: alpha-adrenergic receptor activity Function: alpha2-adrenergic receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:281,Cell membrane,,"","",None,"34-59 71-96 107-129 150-173 193-217 375-399 407-430",Non Essential,1HOF,ADRA2A,ADRA2A,BC050414,"","" 1144,Sodium-dependent dopamine transporter,2009-07-22 22:35:20 UTC,2009-08-13 06:39:27 UTC,Q01959,Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals,"",">Sodium-dependent dopamine transporter MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFL LSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKG VGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGT TPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTAL LLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTT SINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLI EAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANAL GWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV",SLC6A3,DA transporter; DAT; Solute carrier family 6 member 3,620,68496,6.92,">>> Function: dopamine:sodium symporter activity Function: transporter activity Function: neurotransmitter transporter activity Function: neurotransmitter:sodium symporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: neurotransmitter transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane Component: integral to plasma membrane","",PF00209:SNF,HGNC:11049,Membrane,,"","",None,"69-89 96-116 140-160 238-256 265-282 318-335 347-368 401-420 447-465 481-501 522-541 560-578",Non Essential,"",SLC6A3,SLC6A3,D88570,"","" 1145,Cocaine- and amphetamine-regulated transcript protein,2009-07-22 22:35:20 UTC,2009-08-13 06:39:34 UTC,Q16568,Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro,"",">Cocaine- and amphetamine-regulated transcript protein MESSRVRLLPLLGAALLLMLPLLGTRAQEDAELQPRALDIYSAVDDASHEKELIEALQEVLKKLKSKRVP IYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL",CARTPT,Contains: RecName: CART(1-39); Contains: RecName: CART(42-89),116,12829,8.37,"","",PF06373:CART,HGNC:24323,Secreted (Potential),,"","",1-27,None,Non Essential,1HY9,CARTPT,CARTPT,BC029882,"","" 1146,Trace amine-associated receptor 1,2009-07-22 22:35:20 UTC,2009-08-13 06:39:58 UTC,Q96RJ0,"Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase","",">Trace amine-associated receptor 1 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDF LLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVI CVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVY YRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYI IPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS",TAAR1,Trace amine receptor 1; TaR-1,339,39092,8.82,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:17734,Cell membrane,,"","",None,"26-46 60-80 99-119 137-157 189-209 253-273 288-308",Non Essential,"",TAAR1,TAAR1,BC112194,"","" 1147,Metabotropic glutamate receptor 2,2009-07-22 22:35:20 UTC,2009-08-13 06:39:50 UTC,Q14416,Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization,"",">Metabotropic glutamate receptor 2 MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALD RINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVI GGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTV ASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLA ASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWE QRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASP SAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEY IRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTA VCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVV EAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTC IIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL",GRM2,mGluR2,872,95569,8.16,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: metabotropic glutamate, GABA-B-like receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane",Amino acid transport and metabolism,"PF00003:7tm_3 PF01094:ANF_receptor PF07562:NCD3G",HGNC:4594,Cell membrane,,"","",1-18,"568-590 605-625 637-655 680-700 726-747 761-783 794-819",Non Essential,"",GRM2,GRM2,BC113619,"","" 1148,Acetylcholine-binding protein,2009-07-22 22:35:20 UTC,2009-08-13 06:39:33 UTC,P58154,Binds to acetylcholine. Modulates neuronal synaptic transmission,"",">Acetylcholine-binding protein MRRNIFCLACLWIVQACLSLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVV FWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRF SCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEA YEDVEVSLNFRKKGRSEIL","",ACh-binding protein; AchBP,229,26062,4.81,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity || >>> Process: ion transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: postsynaptic membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","",PF02931:Neur_chan_LBD,"","Secreted. Cell junction, synapse",,"","",1-19,None,Essential,1I9B,"","",AF364899,"","" 1149,Metabotropic glutamate receptor 3,2009-07-22 22:35:20 UTC,2009-08-13 06:39:35 UTC,Q14832,Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity,"",">Metabotropic glutamate receptor 3 MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLE AMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPL LIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNW TYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDD SRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPW FRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETL SLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLT GCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTF FFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQI VMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKF IGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL",GRM3,mGluR3,879,98880,7.70,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: metabotropic glutamate, GABA-B-like receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane",Amino acid transport and metabolism,"PF00003:7tm_3 PF01094:ANF_receptor PF07562:NCD3G",HGNC:4595,Cell membrane,,"","",1-22,"577-599 614-634 646-664 689-709 735-756 770-792 803-828",Non Essential,"",GRM3,GRM3,BC041407,"","" 1150,Cytochrome P450-cam,2009-07-22 22:35:21 UTC,2009-08-13 06:39:39 UTC,P00183,Involved in a camphor oxidation system,"",">Camphor 5-monooxygenase MTTETIQSNANLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWAVLQESNVPDLVWTRCNGGHWIATRGQ LIREAYEDYRHFSSECPFIPREAGEAYDFIPTSMDPPEQRQFRALANQVVGMPVVDKLENRIQELACSLI ESLRPQGQCNFTEDYAEPFPIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPIIE QRRQKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVGGLDTVVNFLSFSMEFLAKSPEHRQELIERPE RIPAACEELLRRFSLVADGRILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHVDFSRQKVSHTT FGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALPLVWDPATTKAV",camC,Cytochrome P450-cam; P450cam,415,46670,5.08,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,"",Cytoplasm (By similarity),,"","",None,None,Essential,1IWI,camC,"",D00528,"","" 1151,Translocator protein,2009-07-22 22:35:21 UTC,2009-08-13 06:40:00 UTC,P30536,Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity),"",">Translocator protein MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKE LGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPY LAWLAFATTLNYCVWRDNHGWHGGRRLPE",TSPO,Peripheral-type benzodiazepine receptor; PBR; PKBS; Mitochondrial benzodiazepine receptor,169,18779,9.33,">>> Function: Not Available || >>> Process: Not Available || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,PF03073:TspO_MBR,HGNC:1158,Mitochondrion membrane,,"","",None,"6-26 47-67 80-100 106-126 135-155",Non Essential,"",TSPO,TSPO,BC001110,"","" 1152,Sodium-dependent noradrenaline transporter,2009-07-22 22:35:23 UTC,2009-08-13 06:39:49 UTC,P23975,Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals,"",">Sodium-dependent noradrenaline transporter MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVV GFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYA VILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPA AEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVH GVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSIN CITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAI GVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWG IALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI",SLC6A2,Norepinephrine transporter; NET; Solute carrier family 6 member 2,617,69333,7.53,">>> Function: transporter activity Function: neurotransmitter transporter activity Function: neurotransmitter:sodium symporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: neurotransmitter transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane Component: integral to plasma membrane","",PF00209:SNF,HGNC:11048,Membrane,,"","",None,"65-85 93-112 136-156 235-253 262-279 315-332 344-365 398-417 444-462 478-498 519-538 557-575",Non Essential,"",SLC6A2,SLC6A2,X91117,"","" 1153,Amine oxidase [flavin-containing] A,2009-07-22 22:35:24 UTC,2009-08-13 06:39:34 UTC,P21397,"Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine","",">Amine oxidase [flavin-containing] A MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYV GPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPT DAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSV TNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAK IHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIM GFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTF WERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS",MAOA,Monoamine oxidase type A; MAO-A,527,59682,7.96,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Amino acid transport and metabolism,PF01593:Amino_oxidase,HGNC:6833,Mitochondrion outer membrane,,"","",None,498-518,Non Essential,1O5W,MAOA,MAOA,S72704,"","" 1154,Amine oxidase [flavin-containing] B,2009-07-22 22:35:24 UTC,2009-08-13 06:39:51 UTC,P27338,Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine,"",">Amine oxidase [flavin-containing] B MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILR LAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLA EEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKF VGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPM MRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKAR KLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVP GLLRLIGLTTIFSATALGFLAHKRGLLVRV",MAOB,Monoamine oxidase type B; MAO-B,520,58764,7.55,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Amino acid transport and metabolism,PF01593:Amino_oxidase,HGNC:6834,Mitochondrion outer membrane,,"","",None,490-516,Non Essential,2BK3,MAOB,MAOB,Z95125,"","" 1155,Mu-type opioid receptor,2009-07-22 22:35:24 UTC,2009-08-13 06:39:27 UTC,P35372,Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin,"",">Mu-type opioid receptor MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITA ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTI LCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATT KYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRI TRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFR EFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP",OPRM1,MOR-1,400,44780,8.29,">>> Function: peptide receptor activity, G-protein coupled Function: opioid receptor activity Function: mu-opioid receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:8156,Cell membrane,,"","",None,"67-96 106-123 146-165 196-211 237-259 283-305 314-330",Non Essential,"",OPRM1,OPRM1,AF153500,"","" 1156,Cytochrome P450 51,2009-07-22 22:35:25 UTC,2009-08-13 06:39:31 UTC,P10614,"Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol","",">Cytochrome P450 51 MSATKSIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAV VYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIY DCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASR SLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQD RDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDG GKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYF PNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRT LKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRNPEQKI",ERG11,CYPLI; P450-LIA1; Sterol 14-alpha demethylase; Lanosterol 14-alpha demethylase; P450-14DM,530,60721,8.95,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,"",Membrane,,"","",None,21-41,Essential,"",ERG11,"",U10555,"","" 1157,Cytochrome P450 51A1,2009-07-22 22:35:25 UTC,2009-08-13 06:39:51 UTC,Q16850,"Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol","",">Cytochrome P450 51A1 MLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPF LGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG KGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCL HGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDD ILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLP PLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHT PENPVIRYKRRSK",CYP51A1,CYPLI; P450LI; Sterol 14-alpha demethylase; Lanosterol 14-alpha demethylase; LDM; P450-14DM; P45014DM,503,56807,8.72,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2649,Endoplasmic reticulum membrane (Potential). Microsome membrane (Potential),,"","",None,24-44,Non Essential,"",CYP51A1,CYP51A1,U51692,"","" 1158,Methionine synthase,2009-07-22 22:35:26 UTC,2009-08-13 06:39:45 UTC,Q99707,"Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity)","",">Methionine synthase MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDIL SITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKR FVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQ NLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTA YVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATA FEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDG MLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKK YGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHA TKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQL CEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKK YPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDP YQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEM IFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIM EEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFD VWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEA AVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDD YSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMW RLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPIL GYDTD",MTR,5-methyltetrahydrofolate--homocysteine methyltransferase; Vitamin-B12 dependent methionine synthase; MS,1265,140529,5.27,">>> Function: homocysteine S-methyltransferase activity Function: vitamin binding Function: cobalamin binding Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: S-methyltransferase activity Function: methionine synthase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: dihydropteroate synthase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: cobalt ion binding || >>> Process: amino acid and derivative metabolism Process: amino acid metabolism Process: sulfur amino acid metabolism Process: sulfur amino acid biosynthesis Process: methionine biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: aromatic compound metabolism Process: folic acid and derivative metabolism Process: folic acid and derivative biosynthesis || >>> Component: cell Component: intracellular",Amino acid transport and metabolism,"PF02310:B12-binding PF02607:B12-binding_2 PF02965:Met_synt_B12 PF00809:Pterin_bind PF02574:S-methyl_trans",HGNC:7468,Cytoplasm,,"","",None,None,Non Essential,"",MTR,MTR,CH471098,"","" 1159,Adenosine A1 receptor,2009-07-22 22:35:26 UTC,2009-08-13 06:39:37 UTC,P30542,Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase,"",">Adenosine receptor A1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILIN IGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGL TPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQ LNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGN SAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD",ADORA1,"",326,36512,8.75,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: nucleotide receptor activity, G-protein coupled Function: purinergic nucleotide receptor activity, G-protein coupled Function: adenosine receptor activity, G-protein coupled Function: A1 adenosine receptor activity, G-protein coupled || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:262,Cell membrane,,"","",None,"11-33 47-69 81-102 124-146 177-201 236-259 268-292",Non Essential,"",ADORA1,ADORA1,BC026340,"","" 1160,"cAMP-specific 3',5'-cyclic phosphodiesterase 4B",2009-07-22 22:35:26 UTC,2009-08-13 06:39:36 UTC,Q07343,May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents,"",">cAMP-specific 3',5'-cyclic phosphodiesterase 4B MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDG ISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDS DYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNP QEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFL DKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGL NIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMV HCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW ADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHS YFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT",PDE4B,DPDE4; PDE32,736,83344,4.89,">>> Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric diester hydrolase activity Function: cyclic-nucleotide phosphodiesterase activity Function: 3',5'-cyclic-nucleotide phosphodiesterase activity Function: catalytic activity || >>> Process: cellular process Process: cell communication Process: signal transduction || >>> Component: Not Available","",PF00233:PDEase_I,HGNC:8781,Cytoplasmic,,"","",None,None,Non Essential,1TB5,PDE4B,PDE4B,U85048,"","" 1161,Adenosine A2a receptor,2009-07-22 22:35:26 UTC,2009-08-13 06:39:35 UTC,P29274,Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase,"",">Adenosine receptor A2a MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGF CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPM LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQ MESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTN SVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGS APHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS",ADORA2A,"",412,44708,8.05,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: nucleotide receptor activity, G-protein coupled Function: purinergic nucleotide receptor activity, G-protein coupled Function: adenosine receptor activity, G-protein coupled Function: A2A adenosine receptor activity, G-protein coupled || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:263,Cell membrane,,"","",None,"8-30 44-66 78-100 121-143 174-198 235-258 267-290",Non Essential,"",ADORA2A,ADORA2A,BC013780,"","" 1162,Synaptic vesicular amine transporter,2009-07-22 22:35:26 UTC,2009-08-13 06:39:32 UTC,Q05940,"Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis","",">Synaptic vesicular amine transporter MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTAS ISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKAT VQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASV YTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQ KGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGI LAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPI KTKMYTQNNIQSYPIGEDEESESD",SLC18A2,Vesicular amine transporter 2; VAT2; Monoamine transporter; Solute carrier family 18 member 2,514,55714,5.91,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF07690:MFS_1,HGNC:10935,Cytoplasmic vesicle membrane,,"","",None,"21-41 130-150 160-180 190-210 220-242 249-271 292-311 329-352 358-378 390-410 415-435 441-462",Non Essential,"",SLC18A2,SLC18A2,BC108928,"","" 1163,5-hydroxytryptamine 1D receptor,2009-07-22 22:35:27 UTC,2009-08-13 06:39:37 UTC,P28221,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity","",">5-hydroxytryptamine receptor 1D MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLH TPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAI TDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPS VLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIK LADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSL INPIIYTVFNEEFRQAFQKIVPFRKAS",HTR1D,5-HT-1D; 5-HT-1D-alpha; Serotonin receptor 1D,377,41907,8.85,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5289,Cell membrane,,"","",None,"39-62 76-98 109-134 155-176 195-218 303-326 336-360",Non Essential,"",HTR1D,HTR1D,BC007720,"","" 1164,5-hydroxytryptamine 7 receptor,2009-07-22 22:35:27 UTC,2009-08-13 06:40:01 UTC,P34969,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase","",">5-hydroxytryptamine receptor 7 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGC GEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLS ASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPR VEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTAR PFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD",HTR7,5-HT-7; 5HT7; 5-HT-X; Serotonin receptor 7,479,53556,8.97,">>> Function: peptide receptor activity, G-protein coupled Function: melanocortin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5302,Cell membrane,,"","",None,"84-104 118-138 158-178 202-222 237-257 326-346 368-388",Non Essential,"",HTR7,HTR7,BC047526,"","" 1165,5-hydroxytryptamine 1E receptor,2009-07-22 22:35:27 UTC,2009-08-13 06:39:34 UTC,P28566,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity","",">5-hydroxytryptamine receptor 1E MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLL VAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAA LMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAK SLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQ ISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNED FKLAFKKLIRCREHT",HTR1E,5-HT-1E; 5-HT1E; Serotonin receptor 1E; S31,365,41683,8.98,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5291,Cell membrane,,"","",None,"23-47 60-81 97-118 139-159 180-201 292-314 325-347",Non Essential,"",HTR1E,HTR1E,AB041373,"","" 1166,5-hydroxytryptamine 1F receptor,2009-07-22 22:35:27 UTC,2009-08-13 06:39:45 UTC,P30939,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity","",">5-hydroxytryptamine receptor 1F MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDF LVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHA GIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKT LYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRR QKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIF NEDFKKAFQKLVRCRC",HTR1F,5-HT-1F; Serotonin receptor 1F,366,41709,9.08,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5292,Cell membrane,,"","",None,"24-48 61-83 95-119 140-161 179-202 292-314 328-351",Non Essential,"",HTR1F,HTR1F,BC069125,"","" 1167,5-hydroxytryptamine 1B receptor,2009-07-22 22:35:28 UTC,2009-08-13 06:39:51 UTC,P28222,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity","",">5-hydroxytryptamine receptor 1B MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFV IATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHL CVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTV YSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSE SGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAI FDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS",HTR1B,5-HT-1D-beta; 5-HT-1B; 5-HT1B; Serotonin receptor 1B; Serotonin 1D beta receptor; S12,390,43568,8.82,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5287,Cell membrane,,"","",None,"50-73 87-109 120-145 166-187 206-229 316-340 348-373",Non Essential,"",HTR1B,HTR1B,BC096208,"","" 1168,Glycine receptor subunit alpha-1,2009-07-22 22:35:28 UTC,2009-08-13 06:39:27 UTC,P23415,The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing),"",">Glycine receptor subunit alpha-1 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCN IFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEIT TDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGL TLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPAR VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRR HHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ",GLRA1,Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit,457,52625,9.04,">>> Function: neurotransmitter receptor activity Function: anion channel activity Function: chloride channel activity Function: glycine-gated chloride channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4326,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-28,"248-274 281-298 313-336 429-446",Non Essential,"",GLRA1,GLRA1,BC114947,"","" 1169,"ATP synthase delta chain, mitochondrial",2009-07-22 22:35:29 UTC,2009-08-13 06:39:35 UTC,P30049,"Mitochondrial membrane ATP synthase (F(1)F(O) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits","",">ATP synthase subunit delta, mitochondrial MLPAALLRRPGLGRLVRHARAYAEAAAAPAAASGPNQMSFTFASPTQVFFNGANVRQVDVPTLTGAFGIL AAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSIAVNADSSVQLLAEEAVTLDMLDLGAAKANLEKAQAE LVGTADEATRAEIQIRIEANEALVKALE",ATP5D,F-ATPase delta subunit,168,17490,5.19,">>> Function: hydrogen-transporting ATPase activity, rotational mechanism Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: monovalent inorganic cation transporter activity Function: hydrogen ion transporter activity Function: hydrogen-transporting ATP synthase activity, rotational mechanism || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: cofactor metabolism Process: coenzyme metabolism Process: group transfer coenzyme metabolism Process: nucleoside phosphate metabolism Process: ATP biosynthesis Process: ATP synthesis coupled proton transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane Component: proton-transporting two-sector ATPase complex",Energy production and conversion,"PF00401:ATP-synt_DE PF02823:ATP-synt_DE_N",HGNC:837,Mitochondrion. Mitochondrion inner membrane,,"","",None,None,Non Essential,1E79,ATP5D,ATP5D,BC018079,"","" 1170,Ergosterol biosynthetic protein 28,2009-07-22 22:35:29 UTC,2009-08-13 06:39:30 UTC,P40030,"Has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. May also be responsible for facilitating their interaction","",">Ergosterol biosynthetic protein 28 MFSLQDVITTTKTTLAAMPKGYLPKWLLFISIVSVFNSIQTYVSGLELTRKVYERKPTETTHLSARTFGT WTFISCVIRFYGAMYLNEPHIFELVFMSYMVALFHFGSELLIFRTCKLGKGFMGPLVVSTTSLVWMYKQR EYYTGVAW",ERG28,"",148,17135,9.71,">>> Function: molecular function unknown || >>> Process: Not Available || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF03694:Erg28,"",Endoplasmic reticulum membrane,,"","",None,"26-46 93-113 121-136",Essential,"",ERG28,"",AY558453,"","" 1171,D(2) dopamine receptor,2009-07-22 22:35:30 UTC,2009-08-13 06:39:39 UTC,P14416,This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase,"",">D(2) dopamine receptor MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTN YLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPM LYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYI KIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELE MEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGK TRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA VNPIIYTTFNIEFRKAFLKILHC",DRD2,Dopamine D2 receptor,443,50620,9.85,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: dopamine receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:3023,Cell membrane,,"","",None,"38-60 72-97 109-130 152-174 187-210 374-397 406-429",Non Essential,"",DRD2,DRD2,BC021195,"","" 1172,D(3) dopamine receptor,2009-07-22 22:35:30 UTC,2009-08-13 06:39:28 UTC,P35462,This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase,"",">D(3) dopamine receptor MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVS LAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQH GTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYAR IYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREE KTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHV LNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC",DRD3,"",400,44225,9.07,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: dopamine receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:3024,Cell membrane,,"","",None,"33-55 67-92 105-126 150-172 186-209 330-351 367-388",Non Essential,"",DRD3,DRD3,BC095510,"","" 1173,Histamine H1 receptor,2009-07-22 22:35:31 UTC,2009-08-13 06:40:00 UTC,P35367,"In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system","",">Histamine H1 receptor MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLS VADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRT KTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFY AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTP KEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQ MLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS",HRH1,"",487,55785,9.58,">>> Function: amine receptor activity Function: histamine receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5182,Cell membrane,,"","",None,"30-49 64-83 102-123 146-165 190-210 419-438 451-470",Non Essential,"",HRH1,HRH1,AY136743,"","" 1174,D(4) dopamine receptor,2009-07-22 22:35:31 UTC,2009-08-13 06:39:52 UTC,P21917,This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase,"",">D(4) dopamine receptor MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTN SFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVP LRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLL LYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAP AAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLP PDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALC PACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC",DRD4,Dopamine D4 receptor; D(2C) dopamine receptor,467,48361,8.37,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: dopamine receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","Cell cycle control, cell division, chromosome partitioning",PF00001:7tm_1,HGNC:3025,Cell membrane,,"","",None,"38-60 71-93 110-131 152-175 192-213 395-417 427-449",Non Essential,"",DRD4,DRD4,L12398,"","" 1175,Beta-1 adrenergic receptor,2009-07-22 22:35:31 UTC,2009-08-13 06:39:59 UTC,P08588,Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity,"",">Beta-1 adrenergic receptor MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVL LIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVL CVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCY NDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPV PAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFH RELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGP PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV",ADRB1,Beta-1 adrenoreceptor; Beta-1 adrenoceptor,477,51323,9.03,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: adrenoceptor activity Function: beta-adrenergic receptor activity Function: beta1-adrenergic receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:285,Cell membrane,,"","",None,"60-83 97-120 132-155 176-199 222-245 326-349 357-380",Non Essential,"",ADRB1,ADRB1,AY567837,"","" 1176,D-alanine--D-alanine ligase A,2009-07-22 22:35:33 UTC,2009-08-13 06:39:48 UTC,P0A6J8,Cell wall formation,"",">D-alanine--D-alanine ligase A MEKLRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWHVSDASNYLLNADDPAHIALR PSATSLAQVPGKHEHQLIDAQNGQPLPTVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMD KDVTKRLLRDAGLNIAPFITLTRANRHNISFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYAIAVDL AFEFDHKVIVEQGIKGREIECAVLGNDNPQASTCGEIVLTSDFYAYDTKYIDEDGAKVVVPAAIAPEIND KIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINTLPGFTNISMYPKLWQASGLGYTDLITRLIELA LERHAADNALKTTM",ddlA,D-alanylalanine synthetase A; D-Ala-D-Ala ligase A,364,39316,4.81,">>> Function: ligase activity Function: ligase activity, forming carbon-nitrogen bonds Function: acid-amino acid ligase activity Function: D-alanine-D-alanine ligase activity Function: catalytic activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism Process: cellular carbohydrate metabolism Process: peptidoglycan metabolism Process: peptidoglycan biosynthesis || >>> Component: external encapsulating structure Component: cell wall Component: cell Component: intracellular Component: cytoplasm",Cell wall/membrane/envelope biogenesis,"PF07478:Dala_Dala_lig_C PF01820:Dala_Dala_lig_N","",Cytoplasm,,"","",None,None,Essential,"",ddlA,"",AP009048,"","" 1177,Alanine racemase,2009-07-22 22:35:33 UTC,2009-08-13 06:39:33 UTC,Q9L888,Provides the D-alanine required for cell wall biosynthesis,"",">Alanine racemase MAVTPISLTPGVLAEALVDLGAIEHNVRLLCEQARGAQVMAVVKADGYGHGAVQTARAALAAGAAELGVA TVDEALALRAAGISAPVLAWLHPPGIDFRPALLAGVQIGLSSQRQLDELLTAVRDTGRTATVTVKVDTGL NRNGVPPAQYPSMLTALRRAVAEQAIVPRGLMSHMVYADQPANPVNDVQAQRFTDMLAQAREQGVRFEVA HLSNSSATMSRPDLAFDMVRPGIAVYGLSPVPELGDMGLVPAMTVKCTVALVKSIRAGESVSYGHTWTAQ RDTNLALLPVGYADGIFRSLGGRLQVSINGRRRPGVGRICMDQFVVDLGPGRPDVAEGDEAILFGPGSNG EPTAQDWADLLGTIHYEVVTSPRGRITRTYREAHTVES",alr,"",388,41002,6.52,">>> Function: catalytic activity Function: isomerase activity Function: racemase and epimerase activity Function: racemase and epimerase activity, acting on amino acids and derivatives Function: alanine racemase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: pyruvate family amino acid metabolism Process: alanine metabolism || >>> Component: Not Available",Cell wall/membrane/envelope biogenesis,"PF00842:Ala_racemase_C PF01168:Ala_racemase_N","","",,"","",None,None,Essential,"",alr,"","","","" 1178,Histamine H2 receptor,2009-07-22 22:35:33 UTC,2009-08-13 06:39:31 UTC,P25021,"The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity)","",">Histamine H2 receptor MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLL VLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLV LIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVAR DQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYAN SALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEV TAPQGATDR",HRH2,H2R; Gastric receptor I,359,40099,9.39,">>> Function: amine receptor activity Function: histamine receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5183,Cell membrane,,"","",None,"23-44 58-81 93-114 135-159 181-204 235-258 268-289",Non Essential,"",HRH2,HRH2,X98133,"","" 1179,Thyroid hormone receptor beta-1,2009-07-22 22:35:34 UTC,2009-08-13 06:39:53 UTC,P10828,High affinity receptor for triiodothyronine,"",">Thyroid hormone receptor beta MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHL DHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLH PSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGH KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAI TRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVS DAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED",THRB,Nuclear receptor subfamily 1 group A member 2,461,52788,7.11,">>> Function: thyroid hormone receptor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:11799,Nucleus,,"","",None,None,Non Essential,1Y0X,THRB,THRB,AY286471,"","" 1180,Thyroid hormone receptor alpha,2009-07-22 22:35:34 UTC,2009-08-13 06:39:46 UTC,P10827,Nuclear hormone receptor. High affinity receptor for triiodothyronine,"",">Thyroid hormone receptor alpha MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITC EGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQ NRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKV DLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFE HYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP",THRA,Nuclear receptor subfamily 1 group A member 1; C-erbA-alpha; c-erbA-1; EAR-7; EAR7,490,54816,6.85,">>> Function: thyroid hormone receptor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:11796,Nucleus,,"","",None,None,Non Essential,1NAV,THRA,THRA,AF522368,"","" 1181,Thyroid hormone receptor beta-2,2009-07-22 22:35:35 UTC,2009-07-22 22:35:35 UTC,P37243,,,,,,,,,,,,,,,,,,,,,,,,, 1182,Epidermal growth factor receptor,2009-07-22 22:35:35 UTC,2009-08-13 06:39:51 UTC,P00533,Isoform 2/truncated isoform may act as an antagonist,"",">Epidermal growth factor receptor MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNL QEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKL TKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVN PEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLS INATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKI ISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHP ECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTG PGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPN QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD NPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTF GSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLV IQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACI DRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPS RDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGS TAENAEYLRVAPQSSEFIGA",EGFR,Receptor tyrosine-protein kinase ErbB-1,1210,134279,6.67,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: epidermal growth factor receptor activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein-tyrosine kinase activity Function: transmembrane receptor protein tyrosine kinase activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: enzyme linked receptor protein signaling pathway Process: transmembrane receptor protein tyrosine kinase signaling pathway Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: cell Component: membrane","","PF00757:Furin-like PF07714:Pkinase_Tyr PF01030:Recep_L_domain",HGNC:3236,Isoform 2:Secreted,,"","",1-24,646-668,Non Essential,1IVO,EGFR,EGFR,M11234,"","" 1183,DNA ligase 3,2009-07-22 22:35:37 UTC,2009-08-13 06:39:45 UTC,P49916,Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents,"",">DNA ligase 3 MAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKI EDLTELEGWEELEDNEKEQITQHIADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFS GFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLCAMVADNPSYNTKTQIIQDFLRKGSAGD GFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQSKSFPPA AKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNA YEAFKASRNLQDVVERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEI KYDGERVQVHKNGDHFSYFSRSLKPVLPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTGKPLPFGTL GVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPNRIMFSEMKRVTKALDLADMIT RVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYD PGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGA EFSKSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEEN KGPSGSAVSRKAPSKPSASTKKAEGKLSNSNSKDGNMQTAKPSAMKVGEKLATKSSPVKVGEKRKAADET LCQTKVLLDIFTGVRLYLPPSTPDFSRLRRYFVAFDGDLVQEFDMTSATHVLGSRDKNPAAQQVSPEWIW ACIRKRRLVAPC",LIG3,DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3,922,102692,9.17,">>> Function: DNA ligase (ATP) activity Function: nucleic acid binding Function: DNA binding Function: DNA ligase (ATP) activity Function: DNA ligase (ATP) activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: ligase activity Function: ligase activity, forming phosphoric ester bonds Function: DNA ligase activity Function: DNA ligase (ATP) activity || >>> Process: DNA recombination Process: DNA repair Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA replication || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: cell Component: intracellular","Replication, recombination and repair","PF04679:DNA_ligase_A_C PF01068:DNA_ligase_A_M PF04675:DNA_ligase_A_N PF00645:zf-PARP",HGNC:6600,Nucleus,,"","",None,None,Non Essential,1UW0,LIG3,LIG3,AF491645,"","" 1184,DNA ligase 1,2009-07-22 22:35:37 UTC,2009-08-13 06:39:42 UTC,P18858,"This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA","",">DNA ligase 1 MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEE EDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQ SEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQE LQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDAC WKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVG DGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAE ARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEE AAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKK QIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLD TKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGK RAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGED SGSDPEDTY",LIG1,DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1,919,101737,5.30,">>> Function: DNA ligase (ATP) activity Function: nucleic acid binding Function: DNA binding Function: DNA ligase (ATP) activity Function: DNA ligase (ATP) activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: ligase activity Function: ligase activity, forming phosphoric ester bonds Function: DNA ligase activity Function: DNA ligase (ATP) activity || >>> Process: DNA recombination Process: DNA repair Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA replication || >>> Component: Not Available","Replication, recombination and repair","PF04679:DNA_ligase_A_C PF01068:DNA_ligase_A_M PF04675:DNA_ligase_A_N",HGNC:6598,Nucleus,,"","",None,None,Non Essential,1X9N,LIG1,LIG1,BC108318,"","" 1185,Delta-type opioid receptor,2009-07-22 22:35:37 UTC,2009-08-13 06:39:37 UTC,P41143,Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins,"",">Delta-type opioid receptor MEPAPSAGAELQPPLFANASDAYPSAFPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLV MFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLT MMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWD TVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIF VIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRARE ATARERVTACTPSDGPGGGAAA",OPRD1,DOR-1,372,40413,9.17,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: peptide receptor activity, G-protein coupled Function: opioid receptor activity Function: delta-opioid receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:8153,Cell membrane,,"","",None,"46-75 85-102 125-144 175-190 216-238 262-284 294-310",Non Essential,"",OPRD1,OPRD1,AL009181,"","" 1186,"Prostaglandin E2 receptor, EP1 subtype",2009-07-22 22:35:38 UTC,2009-08-13 06:39:32 UTC,P34995,Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues,"",">Prostaglandin E2 receptor EP1 subtype MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSA ATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVT RPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASL GLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSR SSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWV YILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF",PTGER1,"Prostanoid EP1 receptor; PGE receptor, EP1 subtype",402,41802,12.22,">>> Function: prostaglandin E receptor activity Function: icosanoid receptor activity Function: prostanoid receptor activity Function: prostaglandin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:9593,Cell membrane,,"","",None,"36-62 73-96 112-133 156-177 202-227 295-321 333-354",Non Essential,"",PTGER1,PTGER1,BC051286,"","" 1187,Histone deacetylase 9,2009-07-22 22:35:39 UTC,2009-08-13 06:39:53 UTC,Q9UKV0,"Isoform 3, called MITR/HDRP, lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting c-Jun phosphorylation by MAPK10 and by repressing c-Jun transcription via HDAC1 recruitment to c-Jun promoter","",">Histone deacetylase 9 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQK QHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVAS TEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAK DDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNN GPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEK QKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSK SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI QEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPG SATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSL LYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGEL KNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVS AGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPL AEDILHQSPNMNAVISLQKIIEIQSMSLKFS",HDAC9,HD9; HD7B; HD7; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR,1011,111298,6.88,"","",PF00850:Hist_deacetyl,HGNC:14065,Nucleus (By similarity),,"","",None,None,Non Essential,"",HDAC9,HDAC9,AF124924,"","" 1188,"Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial",2009-07-22 22:35:39 UTC,2009-08-13 06:39:29 UTC,P45954,"Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent","",">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKK FAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVAVFCE IQNTLINTLIRKHGTEEQKATYLPQLTTEKVGSFCLSEAGAGSDSFALKTRADKEGDYYVLNGSKMWISS AEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIG HGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLT YNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQ LNTIAKHIDAEY",ACADSB,SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase,432,47486,7.00,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-CH group of donors Function: acyl-CoA dehydrogenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Lipid transport and metabolism,"PF00441:Acyl-CoA_dh_1 PF02770:Acyl-CoA_dh_M PF02771:Acyl-CoA_dh_N",HGNC:91,Mitochondrion matrix,,"","",None,None,Non Essential,"",ACADSB,ACADSB,AL831821,"","" 1189,50S ribosomal protein L10,2009-07-22 22:35:39 UTC,2009-08-13 06:39:31 UTC,P0A7J6,Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA (By similarity),"",">50S ribosomal protein L10 MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYMRVVRNTLLRRAVEGTPFE CLKDAFVGPTLIAYSMEHPGAAARLFKEFAKANAKFEVKAAAFEGELIPASQIDRLATLPTYEEAIARLM ATMKEASAGKLVRTLAAVRDAKEAA",rplJ,"",165,17712,9.51,">>> Function: structural molecule activity Function: structural constituent of ribosome || >>> Process: metabolism Process: macromolecule metabolism Process: macromolecule biosynthesis Process: protein biosynthesis Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: ribosome biogenesis and assembly || >>> Component: protein complex Component: ribonucleoprotein complex Component: ribosome Component: cell Component: intracellular","Translation, ribosomal structure and biogenesis",PF00466:Ribosomal_L10,"","",,"","",None,None,Essential,"",rplJ,"",AE014073,"","" 1190,5-hydroxytryptamine 4 receptor,2009-07-22 22:35:39 UTC,2009-08-13 06:39:40 UTC,Q13639,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase","",">5-hydroxytryptamine receptor 4 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVS VLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVL AYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNI VDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTT INGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT",HTR4,5-HT-4; 5-HT4; Serotonin receptor 4,388,43762,7.82,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: adrenoceptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5299,Cell membrane,,"","",None,"20-40 59-79 94-116 138-158 193-213 261-281 295-315",Non Essential,"",HTR4,HTR4,Z48150,"","" 1191,Catechol O-methyltransferase,2009-07-22 22:35:41 UTC,2009-08-13 06:39:51 UTC,P21964,"Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol","",">Catechol O-methyltransferase MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPG NAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIE INPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLL RKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP",COMT,"",271,30037,5.15,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: O-methyltransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF01596:Methyltransf_3,HGNC:2228,Isoform Membrane-bound:Cell membrane,,"","",None,7-26,Non Essential,"",COMT,COMT,BC100018,"","" 1192,D(1A) dopamine receptor,2009-07-22 22:35:43 UTC,2009-08-13 06:39:40 UTC,P21728,This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase,"",">D(1A) dopamine receptor MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSD LLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAA FILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIM IVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGV FVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRL CPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL SVILDYDTDVSLEKIQPITQNGQHPT",DRD1,"",446,49294,8.34,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: dopamine receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:3020,Cell membrane,,"","",None,"24-49 61-87 97-119 139-163 193-218 273-299 313-337",Non Essential,"",DRD1,DRD1,BC096837,"","" 1193,Alpha-1B adrenergic receptor,2009-07-22 22:35:44 UTC,2009-08-13 06:39:40 UTC,P35368,This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system,"",">Alpha-1B adrenergic receptor MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSV ACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAIS IDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLG SFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIA VKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPC SSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGG ASNGGCEAAADVANGQPGFKSNMPLAPGQF",ADRA1B,Alpha 1B-adrenoreceptor; Alpha 1B-adrenoceptor,520,56837,9.79,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: adrenoceptor activity Function: alpha-adrenergic receptor activity Function: alpha1-adrenergic receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:278,Cell membrane,,"","",None,"46-70 84-105 116-141 162-182 202-224 296-319 327-340",Non Essential,"",ADRA1B,ADRA1B,L31773,"","" 1194,"Beta-1,3-glucan synthase",2009-07-22 22:35:46 UTC,2009-07-22 22:35:46 UTC,Q5DRK6,,,,,,,,,,,,,,,,,,,,,,,,, 1195,D1 dopamine receptor-interacting protein calcyon,2009-07-22 22:35:47 UTC,2009-08-13 06:39:46 UTC,Q9NYX4,Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis,"",">Neuron-specific vesicular protein calcyon MVKLGCSFSGKPGKDPGDQDGAAMDSVPLISPLDISQLQPPLPDQVVIKTQTEYQLSSPDQQNFPDLEGQ RLNCSHPEEGRRLPTARMIAFAMALLGCVLIMYKAIWYDQFTCPDGFLLRHKICTPLTLEMYYTEMDPER HRSILAAIGAYPLSRKHGTETPAAWGDGYRAAKEERKGPTQAGAAAAATEPPGKPSAKAEKEAARKAAGS AAPPPAQ",CALY,"",217,23434,6.91,">>> Function: signal transducer activity Function: receptor binding Function: G-protein-coupled receptor binding Function: dopamine receptor binding || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: dopamine receptor signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF06387:Calcyon,HGNC:17938,Cytoplasmic vesicle membrane,,"","",None,88-108,Non Essential,"",CALY,CALY,BC038978,"","" 1196,Histamine H4 receptor,2009-07-22 22:35:47 UTC,2009-08-13 06:39:48 UTC,Q9H3N8,The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist),"",">Histamine H4 receptor MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP LYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVW VLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRC QSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFS QSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFN SFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS",HRH4,HH4R; G-protein coupled receptor 105; GPRv53; SP9144; AXOR35; Pfi-013,390,44496,9.92,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:17383,Cell membrane,,"","",None,"20-40 53-73 88-108 132-152 173-193 305-325 342-362",Non Essential,"",HRH4,HRH4,BC112348,"","" 1197,5-hydroxytryptamine 3 receptor,2009-07-22 22:35:49 UTC,2009-08-13 06:39:27 UTC,P46098,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel","",">5-hydroxytryptamine receptor 3A MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAI LNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIR HQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWE LLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITL LLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLER IAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA",HTR3A,5-HT3R; 5-HT3A; 5-HT-3; Serotonin receptor 3A; Serotonin-gated ion channel receptor,478,55281,7.43,">>> Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:5297,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-23,"242-268 274-292 303-321 456-475",Non Essential,"",HTR3A,HTR3A,BC004453,"","" 1198,Small inducible cytokine A23,2009-07-22 22:35:50 UTC,2009-08-13 06:39:45 UTC,P55773,"Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23","",">C-C motif chemokine 23 MKVSVAALSCLMLVTALGSQARVTKDAETEFMMSKLPLENPVLLDRFHATSADCCISYTPRSIPCSLLES YFETNSECSKPGVIFLTKKGRRFCANPSDKQVQVCMRMLKLDTRIKTRKN",CCL23,Small-inducible cytokine A23; Macrophage inflammatory protein 3; MIP-3; Myeloid progenitor inhibitory factor 1; MPIF-1; CK-beta-8; CKB-8; Contains: RecName: CCL23(19-99); Contains: RecName: CCL23(22-99); Contains: RecName: CCL23(27-99); Contains: RecName: CCL23(30-99),120,13443,9.17,">>> Function: signal transducer activity Function: receptor binding Function: cytokine activity Function: chemokine activity || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response || >>> Component: extracellular region","",PF00048:IL8,HGNC:10622,Secreted,,"","",1-21,None,Non Essential,1G91,CCL23,CCL23,BC093970,"","" 1199,P2Y purinoceptor 12,2009-07-22 22:35:50 UTC,2009-08-13 06:39:55 UTC,Q9H244,Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation,"",">P2Y purinoceptor 12 MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISD LLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLG AKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYT LITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVK ESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM",P2RY12,P2Y12; P2Y12 platelet ADP receptor; P2Y(ADP); ADP-glucose receptor; ADPG-R; P2Y(AC); P2Y(cyc); P2T(AC); SP1999,342,39439,9.99,">>> Function: nucleotide receptor activity, G-protein coupled Function: purinergic nucleotide receptor activity, G-protein coupled Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:18124,Cell membrane,,"","",None,"26-46 59-79 100-120 143-163 192-212 234-254 282-302",Non Essential,"",P2RY12,P2RY12,BC017898,"","" 1200,Tubulin beta chain,2009-07-22 22:35:52 UTC,2009-08-13 06:39:57 UTC,P10875,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin beta chain MREIIHLSTGQCGNQIGAAFWETICGEHGLDNNGTYVGNNELQKSKLDVYFNEATSGKYVPRAVLVDLEP GTIDNVKTSQIGNLFRPDNFIFGQSSAGNVWAKGHYTEGAELVDSVLDVVRREAEGCDSLQGFQITHSLG GGTGSGMGTLLISKIREEFPDTMMATFSVVPSPKVSDTVIEPYNATLSVHQLVENSDETFCIDNEALYNI CQNTLKLPQPSYAELNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNLVPFPRLHFFMVGYAPLTSMGSKS FRSVTVPELTQQMFDAKNMMAASDPRNGRYLTVAAFFRGKVSVKEVDDEMHKIQTRNSSYFVDWIPNNVQ TAVCSVPPKDLDMSATFIGNSTSIQELFKRVGDQFSAMFRRKAFLHWYTSEGMDEMEFTEAESNMNDLVS EYQQYQEASIDEEELEYADEIPLEDAAME",TUB2,Beta-tubulin,449,49942,4.37,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C","",Cytoplasmic,,"","",None,None,Essential,"",TUB2,"",M19398,"","" 1201,Tubulin alpha chain,2009-07-22 22:35:52 UTC,2009-08-13 06:39:35 UTC,P87066,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha chain MREVISINVGQAGCQIGNACWELYSQEHGIRPDGYLQEGLDRPKGGEEGFSTFFSETGSGKYVPRALYVD LEPNVIDEVRTGVYKDLFHPEQLIAGKEDAANNYARGHYTVGREILDDILDRVRRMSDQCDGLQGFLFTH SLGGGTGSGLGSLLLEQLSLDYGKKSKLEFAVYPAPQVSTSVVEPYNTVLTTHTTLEHADCTFMVDNEAI YDMCRRNLDIARPNFSSLNNLIAQVVSSVTASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVSYAPVFSKS RATHEANSVSEITQSCFEPGNQMVKCDPRTGKYMATCLLYRGDVVTRDVQNAVAQVKSKKTVQLVDWCPT GFKIGICYQPPTAIKGSELASASRAVCMLSNTTAIAEAWRRIDRKFDLMYSKRAFVHWYVGEGMEEGEFT EAREDLAALERDYIEVGTDSFPEEEEEY",TUB1,"",448,49969,4.69,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C","",Cytoplasmic,,"","",None,None,Essential,"",TUB1,"",U38534,"","" 1202,Isoleucyl-tRNA synthetase,2009-07-22 22:35:54 UTC,2009-08-13 06:39:57 UTC,P41972,"Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)","",">Isoleucyl-tRNA synthetase MDYKETLLMPKTDFPMRGGLPNKEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALN KILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMSTAEFREKCKEFALEQIELQKKDFR RLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIEYHDKRSASIYV AFNVKDDKGVVDADAKFIIWTTTPWTIPSNVAITVHPELKYGQYNVNGEKYIIAEALSDAVAEALDWDKA SIKLEKEYTGKELEYVVAQHPFLDRESLVINGDHVTTDAGTGCVHTAPGHGEDDYIVGQKYELPVISPID DKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISKVR QDILDAIENTNFKVNWGKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAENGEIIMTKETVNHVADLFAEH GSNIWFEREAKDLLPEGFTHPGSPNGTFTKETDIMDVWFDSGSSHRGVLETRPELSFPADMYLEGSDQYR GWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLAD VRISDEILKQTSDVYRKIRNTLRFMLGNINDFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFD YLNIYQEVQNFINVELSNFYLDYGKDILYIEQRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSH TPHVKEESVHLADMPKVVEVDQALLDKWRTFMNLRDDVNRALETARNEKVIGKSLEAKVTIASNDKFNAS EFLTSFDALHQLFIVSQVKVVDKLDDQATAYEHGDIVIEHADGEKCERCWNYSEDLGAVDELTHLCPRCQ QVVKSLV",ileS,Isoleucine--tRNA ligase; IleRS,917,104885,5.17,">>> Function: isoleucine-tRNA ligase activity Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: ligase activity Function: ligase activity, forming phosphoric ester bonds Function: RNA ligase activity Function: tRNA ligase activity || >>> Process: isoleucyl-tRNA aminoacylation Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: RNA metabolism Process: tRNA metabolism Process: tRNA aminoacylation Process: tRNA aminoacylation for protein translation || >>> Component: Not Available","Translation, ribosomal structure and biogenesis","PF08264:Anticodon_1 PF00133:tRNA-synt_1 PF06827:zf-FPG_IleRS","",Cytoplasm,,"","",None,None,Essential,1QU2,ileS,"",X74219,"","" 1203,Alpha-1D adrenergic receptor,2009-07-22 22:35:56 UTC,2009-08-13 06:39:33 UTC,P25100,This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium,"",">Alpha-1D adrenergic receptor MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAG EPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAV ADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTE RKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVV ARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTL AIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKP PSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYE LADYSNLRETDI",ADRA1D,Alpha 1D-adrenoreceptor; Alpha 1D-adrenoceptor; Alpha-1A adrenergic receptor; Alpha-adrenergic receptor 1a,572,60463,9.44,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: adrenoceptor activity Function: alpha-adrenergic receptor activity Function: alpha1-adrenergic receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00001:7tm_1,HGNC:280,Cell membrane,,"","",None,"96-121 134-159 170-192 214-238 252-275 349-373 381-405",Non Essential,"",ADRA1D,ADRA1D,AL121675,"","" 1204,Chromodomain-helicase-DNA-binding protein 1,2009-07-22 22:35:58 UTC,2009-08-13 06:40:00 UTC,O14646,Sequence-selective DNA-binding protein. Could play an important role in gene regulation,"",">Chromodomain-helicase-DNA-binding protein 1 MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGSQSESESDTSR ENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNSGSEEDSSSSEDSDDSSSEVK RKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETESDYEPKNKVKSRKPQNRSKSKNGKKILGQKK RQIDSSEEDDDEEDYDNDKRSSRRQATVNVSYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDC RIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLD NYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVGRIIAHSNQKSAAGYPDYYCKWQGLPYSE CSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLN WLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQMNAVV YLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLLYKTL IDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKK DVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDN NEFYNKQEALQHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKG ELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIY RLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFGAEELFKEP EGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFKVANFSNMDEDDIELEPERNSKNWEEIIPED QRRRLEEEERQKELEEIYMLPRMRNCAKQISFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPR ENIKGFSDAEIRRFIKSYKKFGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERT GGRLGKVKGPTFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKKEALSGAGSSK RRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRERSKKSSVSDAPVHITASGEPV PISEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQ IKQWRKNLWIFVSKFTEFDARKLHKLYKHAIKKRQESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSS RDSYSSDRHLTQYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRYYSDREKHRKLDDH RSRDHRSNLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLD QRSYGSRSPFEHSVEHKSTPEHTWSSRKT",CHD1,CHD-1; ATP-dependent helicase CHD1,1709,196520,7.17,">>> Function: DNA binding Function: ATP-dependent helicase activity Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: helicase activity Function: nucleic acid binding Function: binding Function: chromatin binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA packaging Process: establishment and/or maintenance of chromatin architecture Process: chromatin assembly or disassembly || >>> Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: chromosome Component: chromatin",Transcription,"PF00385:Chromo PF00271:Helicase_C PF00176:SNF2_N",HGNC:1915,Nucleus,,"","",None,None,Non Essential,"",CHD1,CHD1,AF006513,"","" 1205,Penicillin-binding proteins 1A/1B,2009-07-22 22:35:59 UTC,2009-08-13 06:39:51 UTC,Q8XJ01,Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity),"",">Penicillin-binding protein 1A MTERKREHKDRKQNKNSPKNQSKVTKFLKWFFIGILLLGITAVTVVGIYVLSIIRSSPELDVQAIQSLNQ PSILYDDQGNFMDNVITREQRYVVKSEEIPDNLKKAFVAIEDERFYEHKGIDIKRIFGVIASNIKGKLSG SNTVQGASTITQQLIKNAVLTNEVSYERKIKEMYLALELEKHLSKDEILTTYLNTIPMGGYQYGVSAAAQ RFFSKNVSDLNLVECAYLGGLTQAPTSYDGLSEANKENPSRYLNRTKSVLFKMHELGYISSEQYNDAINE IDTNGIKFTPNNKLSKTNFEWFTRPAITQVKQDLMDKYKYTQEEVDKLIANGGLKIYTSMDRNLQNNVQK VLDDPNNYKAITNNPNEKNEDGVYKLQASATIIDYKTGHVKALVGGRGEQPAMSHNRAYYDLKSIGSATK PLTVYGPAIDLGLGGAGSVVNDSPLSNKELSSTGYKDQPKNEYNSYRGPLTFREAIKISSNLAAIKVANE VGVSNSIAYGEKLGLVYGPHSRGISTTALGQFQNDPNNPDGGNTYTLASAFGVFGNNGVKTNAKLYTKVL DSHGNVILDTSTPEETKIFSPQASYIVYDMLKDQVESGSAKSAKFGNIPVAGKTGTTTGDKDYLFAGLTP YYSAAIWIGYDKPREMRTSSGTVTSPIFGKIMGLAHKDLQYKEVDNLVE",pbpA,PBP1; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase,679,75178,9.09,">>> Function: binding Function: drug binding Function: penicillin binding Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring pentosyl groups Function: hydrolase activity Function: peptidase activity Function: catalytic activity || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: external encapsulating structure organization and biogenesis Process: cell wall organization and biogenesis Process: cell wall organization and biogenesis (sensu Bacteria) Process: cell wall biosynthesis (sensu Bacteria) Process: response to stimulus Process: response to abiotic stimulus Process: response to chemical stimulus Process: response to drug Process: response to antibiotic Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism Process: cellular carbohydrate metabolism Process: peptidoglycan metabolism Process: peptidoglycan biosynthesis || >>> Component: cell Component: external encapsulating structure Component: cell wall Component: cell wall (sensu Bacteria)",Cell wall/membrane/envelope biogenesis,"PF00912:Transgly PF00905:Transpeptidase","",Cell membrane,,"","",None,31-51,Essential,"",pbpA,"",BA000016,"","" 1206,30S ribosomal protein S12,2009-07-22 22:35:59 UTC,2009-08-13 06:40:00 UTC,P0A7S3,Cryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit,"",">30S ribosomal protein S12 MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGE GHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA",rpsL,"",124,13737,11.49,">>> Function: structural molecule activity Function: structural constituent of ribosome || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: macromolecule biosynthesis Process: protein biosynthesis || >>> Component: small ribosomal subunit Component: protein complex Component: ribonucleoprotein complex Component: ribosome Component: cell Component: intracellular","Translation, ribosomal structure and biogenesis",PF00164:Ribosomal_S12,"","",,"","",None,None,Essential,1P87,rpsL,"",J01688,"","" 1207,C-X-C chemokine receptor type 4,2009-07-22 22:35:59 UTC,2009-08-13 06:39:57 UTC,P61073,"Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus","",">C-X-C chemokine receptor type 4 MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLR SMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVH ATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLIL PGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTV HKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFH SS",CXCR4,CXC-R4; CXCR-4; Stromal cell-derived factor 1 receptor; SDF-1 receptor; Fusin; Leukocyte-derived seven transmembrane domain receptor; LESTR; LCR1; FB22; NPYRL; HM89; CD184 antigen,352,39746,8.30,">>> Function: C-X-C chemokine receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: peptide receptor activity, G-protein coupled Function: G-protein chemoattractant receptor activity Function: chemokine receptor activity Function: C-C chemokine receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:2561,Cell membrane,,"","",None,"40-63 80-99 111-132 155-175 201-220 241-261 286-305",Non Essential,"",CXCR4,CXCR4,BC020968,"","" 1208,Platelet glycoprotein IX,2009-07-22 22:36:01 UTC,2009-08-13 06:39:52 UTC,P14770,The GPIb-V-IX complex functions as the von Willebrand factor receptor and mediates von willebrand factor-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib,"",">Platelet glycoprotein IX MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGA FDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQ ASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD",GP9,GPIX; CD42a antigen,177,19046,6.32,"","","PF01463:LRRCT PF01462:LRRNT",HGNC:4444,Membrane,,REACT_604-Hemostasis;,"",1-16,152-171,Non Essential,"",GP9,GP9,D88290,"","" 1209,Putative renal organic anion transporter 1,2009-07-22 22:36:03 UTC,2009-07-22 22:36:03 UTC,O95742,,,,,,,,,,,,,,,,,,,,,,,,, 1210,Sigma 1-type opioid receptor,2009-07-22 22:36:05 UTC,2009-08-13 06:39:33 UTC,Q99720,"Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration","",">Sigma 1-type opioid receptor MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHP GHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGT TKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGL RLELTTYLFGQDP",OPRS1,Sigma1-receptor; Sigma1R; SIG-1R; hSigmaR1; SR31747-binding protein; SR-BP; Aging-associated gene 8 protein,223,25128,5.87,">>> Function: catalytic activity Function: isomerase activity Function: intramolecular oxidoreductase activity Function: intramolecular oxidoreductase activity, transposing C=C bonds Function: C-8 sterol isomerase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: alcohol metabolism Process: sterol metabolism Process: ergosterol metabolism Process: ergosterol biosynthesis || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: endoplasmic reticulum","",PF04622:ERG2_Sigma1R,HGNC:8157,"Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone",,"","",None,"10-30 81-101",Non Essential,"",OPRS1,OPRS1,BC007839,"","" 1211,"Opioid receptor, sigma 1",2009-07-22 22:36:05 UTC,2009-08-13 06:39:28 UTC,Q5T1J1,"","",">Opioid receptor, sigma 1 (HCG20471, isoform CRA_c) MGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEA TAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP",OPRS1,"",134,14853,5.07,">>> Function: catalytic activity Function: isomerase activity Function: intramolecular oxidoreductase activity Function: intramolecular oxidoreductase activity, transposing C=C bonds Function: C-8 sterol isomerase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: alcohol metabolism Process: sterol metabolism Process: ergosterol metabolism Process: ergosterol biosynthesis || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: endoplasmic reticulum","",PF04622:ERG2_Sigma1R,HGNC:8157,"",,"","",None,None,Non Essential,"",OPRS1,OPRS1,CH471071,"","" 1212,Adenosine deaminase,2009-07-22 22:36:07 UTC,2009-08-13 06:39:44 UTC,P00813,Adenosine + H(2)O = inosine + NH(3),"",">Adenosine deaminase MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMP AIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEG ERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIH RTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAV IRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKA YGMPPSASAGQNL",ADA,Adenosine aminohydrolase,363,40765,5.80,">>> Function: hydrolase activity Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Function: adenosine deaminase activity Function: catalytic activity Function: deaminase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: purine nucleotide metabolism Process: purine nucleotide biosynthesis Process: purine nucleoside monophosphate biosynthesis Process: purine ribonucleoside monophosphate biosynthesis || >>> Component: Not Available","Replication, recombination and repair",PF00962:A_deaminase,HGNC:186,Cytoplasmic,,"","",None,None,Non Essential,"",ADA,ADA,BC040226,"","" 1213,Dihydrofolate reductase,2009-07-22 22:36:08 UTC,2009-08-13 06:39:40 UTC,P00374,"5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH","",">Dihydrofolate reductase MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKG RINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIM QDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND",DHFR,"",187,21453,7.60,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-NH group of donors Function: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Function: dihydrofolate reductase activity || >>> Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: glycine metabolism Process: glycine biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00186:DHFR_1,HGNC:2861,"",,"","",None,None,Non Essential,1MVT,DHFR,DHFR,BC071996,"","" 1214,Solute carrier family 12 member 3,2009-07-22 22:36:09 UTC,2009-08-13 06:39:55 UTC,P55017,Electrically silent transporter system. Mediates sodium and chloride reabsorption,"",">Solute carrier family 12 member 3 MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNTIDVVPTYEHY ANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGWVK GVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRS LGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGME WESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPS ATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYP LIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRP SFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVG LNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWL NKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFEFNYG VCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARVDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDG GLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKR FEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIG RKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYCQ",SLC12A3,Thiazide-sensitive sodium-chloride cotransporter; Na-Cl symporter,1021,113140,7.94,">>> Function: ion transporter activity Function: cation transporter activity Function: anion:cation symporter activity Function: cation:chloride symporter activity Function: transporter activity || >>> Process: anion transport Process: inorganic anion transport Process: chloride transport Process: cation transport Process: monovalent inorganic cation transport Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane","","PF00324:AA_permease PF08403:AA_permease_N",HGNC:10912,Membrane,,"","",None,"136-156 159-179 219-239 262-282 287-307 340-360 378-398 453-473 512-532 535-555 578-598 661-681",Non Essential,"",SLC12A3,SLC12A3,X91220,"","" 1215,Phospholipase A2 VRV-PL-VIIIa,2009-07-22 22:36:11 UTC,2009-08-13 06:39:36 UTC,P59071,"PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This toxin shows neurotoxic symptoms and damages vital organs such as lung, liver and kidney. Displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity","",">Phospholipase A2 VRV-PL-VIIIa SLLEFGKMILEETGKLAIPSYSSYGCYCGWGGKGTPKDATDRCCFVHDCCYGNLPDCNPKSDRYKYKRVN GAIVCEKGTSCENRICECDKAAAICFRQNLNTYSKKYMLYPDFLCKGELKC","",Phosphatidylcholine 2-acylhydrolase; DPLA2; P1,121,13611,8.06,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: carboxylic ester hydrolase activity Function: lipase activity Function: phospholipase activity Function: phospholipase A2 activity || >>> Process: physiological process Process: metabolism Process: primary metabolism Process: lipid metabolism Process: lipid catabolism || >>> Component: Not Available","",PF00068:Phospholip_A2_1,"",Secreted,,"","",None,None,Essential,1Y38,"","","","","" 1216,Evolved beta-galactosidase subunit alpha,2009-07-22 22:36:11 UTC,2009-08-13 06:39:47 UTC,P06864,The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme,"",">Evolved beta-galactosidase subunit alpha MNRWENIQLTHENRLAPRAYFFSYDSVAQARTFARETSSLFLPLSGQWNFHFFDHPLQVPEAFTSELMAD WGHITVPAMWQMEGHGKLQYTDEGFPFPIDVPFVPSDNPTGAYQRIFTLSDGWQGKQTLIKFDGVETYFE VYVNGQYVGFSKGSRLTAEFDISAMVKTGDNLLCVRVMQWADSTYVEDQDMWWSAGIFRDVYLVGKHLTH INDFTVRTDFDEAYCDATLSCEVVLENLAASPVVTTLEYTLFDGERVVHSSAIDHLAIEKLTSASFAFTV EQPQQWSAESPYLYHLVMTLKDANGNVLEVVPQRVGFRDIKVRDGLFWINNRYVMLHGVNRHDNDHRKGR AVGMDRVEKDLQLMKQHNINSVRTAHYPNDPRFYELCDIYGLFVMAETDVESHGFANVGDISRITDDPQW EKVYVERIVRHIHAQKNHPSIIIWSLGNESGYGCNIRAMYHAAKALDDTRLVHYEEDRDAEVVDIISTMY TRVPLMNEFGEYPHPKPRIICEYAHAMGNGPGGLTEYQNVFYKHDCIQGHYVWEWCDHGIQAQDDHGNVW YKFGGDYGDYPNNYNFCLDGLIYSDQTPGPGLKEYKQVIAPVKIHARDLTRGELKVENKLWFTTLDDYTL HAEVRAEGETLATQQIKLRDVAPNSEAPLQITLPQLDAREAFLNITVTKDSRTRYSEAGHPIATYQFPLK ENTAQPVPFAPNNARPLTLEDDRLSCTVRGYNFAITFSKMSGKPTSWQVNGESLLTREPKINFFKPMIDN HKQEYEGLWQPNHLQIMQEHLRDFAVEQSDGEVLIISRTVIAPPVFDFGMRCTYIWRIAADGQVNVALSG ERYGDYPHIIPCIGFTMGINGEYDQVAYYGRGPGENYADSQQANIIDIWRSTVDAMFENYPFPQNNGNRQ HVRWTALTNRHGNGLLVVPQRPINFSAWHYTQENIHAAQHCNELQRSDDITLNLDHQLLGLGSNSWGSEV LDSWRVWFRDFSYGFTLLPVSGGEATAQSLASYEFGAGFFSTNLHSENKQ",ebgA,Lactase,1030,117880,5.25,">>> Function: galactosidase activity Function: beta-galactosidase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on glycosyl bonds Function: hydrolase activity, hydrolyzing O-glycosyl compounds || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: protein complex Component: unlocalized protein complex Component: beta-galactosidase complex",Carbohydrate transport and metabolism,"PF02929:Bgal_small_N PF00703:Glyco_hydro_2 PF02836:Glyco_hydro_2_C PF02837:Glyco_hydro_2_N","",Cytoplasmic,,"","",None,None,Essential,"",ebgA,"",AP009048,"","" 1217,"Carnitine O-palmitoyltransferase I, liver isoform",2009-07-22 22:36:12 UTC,2009-08-13 06:39:37 UTC,P50416,Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine,"",">Carnitine O-palmitoyltransferase 1, liver isoform MAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVM TTMYAKIDPSLGIIAKINRTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEH GKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFA VGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYILPTHIQAARAGNAIHAIL LYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSRIPGEETDTIQHMRDSKHIVVYHRGRYFKVWLYHD GRLLKPREMEQQMQRILDNTSEPQPGEARLAALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTL DETEEGYRSEDPDTSMDSYAKSLLHGRCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMS IDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQEVIETSLNTANLLANDVDFHSFPFVAFGKGIIK KCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMVDPAQTVEQRL KLFKLASEKHQHMYRLAMTGSGIDRHLFCLYVVSKYLAVESPFLKEVLSEPWRLSTSQTPQQQVELFDLE NNPEYVSSGGGFGPVADDGYGVSYILVGENLINFHISSKFSCPETDSHRFGRHLKEAMTDIITLFGLSSN SKK",CPT1A,"CPT1-L; Carnitine O-palmitoyltransferase I, liver isoform; CPTI-L; CPT I; Carnitine palmitoyltransferase 1A",773,88369,8.84,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00755:Carn_acyltransf,HGNC:2328,Mitochondrion outer membrane,,"","",None,"48-73 103-122",Non Essential,"",CPT1A,CPT1A,BC000185,"","" 1218,Organic cation/carnitine transporter 1,2009-07-22 22:36:12 UTC,2009-08-13 06:39:27 UTC,Q9H015,"Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET)","",">Solute carrier family 22 member 4 MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLR LRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNW KVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISN YVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPES PRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWM LTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPV DYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPY IVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVLITAF",SLC22A4,Organic cation/carnitine transporter 1; Ergothioneine transporter; ET transporter,551,62156,7.27,">>> Function: ion transporter activity Function: transporter activity || >>> Process: ion transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF07690:MFS_1,HGNC:10968,Membrane,,"","",None,"21-41 142-162 172-192 198-218 233-253 258-278 338-358 372-392 400-420 427-447 461-481 487-507",Non Essential,"",SLC22A4,SLC22A4,BC028313,"","" 1219,Organic cation/carnitine transporter 2,2009-07-22 22:36:12 UTC,2009-08-13 06:39:44 UTC,O76082,"Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also Relative uptake activity ratio of carnitine to TEA is 11.3","",">Solute carrier family 22 member 5 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLR LRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDW KAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISN YVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPES PRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIML WMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFL PYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF",SLC22A5,Organic cation/carnitine transporter 2; High-affinity sodium-dependent carnitine cotransporter,557,62753,8.04,">>> Function: ion transporter activity Function: transporter activity || >>> Process: ion transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF07690:MFS_1,HGNC:10969,Membrane,,"","",None,"21-41 143-163 173-193 198-218 233-253 258-278 342-362 374-394 407-427 431-451 463-483 489-509",Non Essential,"",SLC22A5,SLC22A5,BC012325,"","" 1220,Mitochondrial carnitine/acylcarnitine carrier protein CACL,2009-07-22 22:36:12 UTC,2009-08-13 06:39:55 UTC,Q8N8R3,Has palmitoylcarnitine transporting activity (By similarity),"",">Mitochondrial carnitine/acylcarnitine carrier protein CACL MALDFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKGLGSPLMGLT FINALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQ IYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPV DVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFATVTVVLTYARGEE AGPEGEAVPAAPAGPALAQPSSL",SLC25A29,CACT-like; Solute carrier family 25 member 29,303,32063,8.89,">>> Function: binding Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: organelle membrane Component: organelle inner membrane Component: mitochondrial inner membrane","",PF00153:Mito_carr,HGNC:20116,Mitochondrion inner membrane,,"","",None,"2-22 61-81 96-116 153-172 187-207 255-275",Non Essential,"",SLC25A29,SLC25A29,"","","" 1221,Mitochondrial carnitine/acylcarnitine carrier protein,2009-07-22 22:36:12 UTC,2009-08-13 06:39:42 UTC,O43772,Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway,"",">Mitochondrial carnitine/acylcarnitine carrier protein MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITG LYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGERIKCLLQI QASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAP RILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPAN AACFLGFEVAMKFLNWATPNL",SLC25A20,Carnitine/acylcarnitine translocase; CAC; Solute carrier family 25 member 20,301,32944,9.84,">>> Function: binding Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: organelle membrane Component: organelle inner membrane Component: mitochondrial inner membrane","",PF00153:Mito_carr,HGNC:1421,Mitochondrion inner membrane,,"","",None,"13-31 74-93 113-131 171-190 212-230 268-287",Non Essential,"",SLC25A20,SLC25A20,BC001689,"","" 1222,Peroxisomal carnitine O-octanoyltransferase,2009-07-22 22:36:13 UTC,2009-08-13 06:39:49 UTC,Q9UKG9,"Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester","",">Peroxisomal carnitine O-octanoyltransferase MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKL LERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLR KEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNYFRTESEGRSPNHIVVLCRGRAFVFDVIHEGC LVTPPELLRQLTYIHKKCHSEPDGPGIAALTSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMED SSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNE GRWKGSEKVRDIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFI QLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKH NKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFVLSTSLVGYLRVQGVVVPMVH NGYGFFYHIRDDRFVVACSAWKSCPETDAEKLVQLTFCAFHDMIQLMNSTHL",CROT,COT,612,70179,7.09,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00755:Carn_acyltransf,HGNC:2366,Peroxisome (Potential),,"","",None,None,Non Essential,"",CROT,CROT,BC039004,"","" 1223,"Carnitine O-palmitoyltransferase 2, mitochondrial",2009-07-22 22:36:13 UTC,2009-08-13 06:39:38 UTC,P23786,Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine,"",">Carnitine O-palmitoyltransferase 2, mitochondrial MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLEDTIRRYLSAQKP LLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFDMYLSARDSVVLNFNPFMAFNPD PKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNPAKSDTITFKRLIRFVPSSLSWYGAYLVNAY PLDMSQYFRLFNSTRLPKPSRDELFTDDKARHLLVLRKGNFYIFDVLDQDGNIVSPSEIQAHLKYILSDS SPAPEFPLAYLTSENRDIWAELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNR WFDKSFNLIIAKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQSQPATTDSTVTVQKLNFELT DALKTGITAAKEKFDATMKTLTIDCVQFQRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYGQTVATYESCS TAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHGQLTKEAAMGQGFDRHLFALR HLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLGGFAPVVSDGFGVGYAVHDNWIGCNVSSYPG RNAREFLQCVEKALEDMFDALEGKSIKS",CPT2,Carnitine palmitoyltransferase II; CPT II,658,73778,8.30,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00755:Carn_acyltransf,HGNC:2330,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",CPT2,CPT2,BC005172,"","" 1224,DNA-directed RNA polymerase alpha chain,2009-07-22 22:36:15 UTC,2009-08-13 06:39:57 UTC,P0A7Z4,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme,"",">DNA-directed RNA polymerase subunit alpha MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYST KEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASI SMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGT IDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGD LVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE",rpoA,RNAP subunit alpha; Transcriptase subunit alpha; RNA polymerase subunit alpha,329,36512,4.70,">>> Function: nucleic acid binding Function: DNA binding Function: binding Function: protein binding Function: protein dimerization activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity || >>> Process: transcription, DNA-dependent Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: Not Available",Transcription,"PF01000:RNA_pol_A_bac PF03118:RNA_pol_A_CTD PF01193:RNA_pol_L","",Cytoplasmic,,"","",None,None,Essential,1BDF,rpoA,"",M29824,"","" 1225,Heat shock protein HSP 90-alpha,2009-07-22 22:36:15 UTC,2009-08-13 06:39:49 UTC,P07900,Molecular chaperone. Has ATPase activity (By similarity),"",">Heat shock protein HSP 90-alpha MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKL DSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYS AYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKI KEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFD LFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKC LELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKH IYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKK QEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDE DDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD",HSP90AA1,HSP 86; Renal carcinoma antigen NY-REN-38,732,84661,4.66,">>> Function: protein binding Function: unfolded protein binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein folding || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones","PF02518:HATPase_c PF00183:HSP90",HGNC:5253,Cytoplasm. Melanosome,,"","",None,None,Non Essential,1UYL,HSP90AA1,HSP90AA1,D87666,"","" 1226,Endoplasmin,2009-07-22 22:36:15 UTC,2009-08-13 06:39:28 UTC,P14625,Molecular chaperone that functions in the processing and transport of secreted proteins. Has ATPase activity (By similarity),"",">Endoplasmin MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELR EKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDK EKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVI VTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIY VWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEV EEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGT NIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLK KGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRR IKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDT TEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL",HSP90B1,Heat shock protein 90 kDa beta member 1; 94 kDa glucose-regulated protein; GRP94; gp96 homolog; Tumor rejection antigen 1,803,92470,4.48,">>> Function: protein binding Function: unfolded protein binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein folding || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones","PF02518:HATPase_c PF00183:HSP90",HGNC:12028,Endoplasmic reticulum lumen. Melanosome,,"","",1-21,None,Non Essential,1QYE,HSP90B1,HSP90B1,AY040226,"","" 1227,Nicotinic acid receptor 1,2009-07-22 22:36:16 UTC,2009-08-13 06:39:39 UTC,Q8TDS4,Acts as a high affinity receptor for nicotinic acid and mediates its anti-lipolytic effect through a G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet,"",">Nicotinic acid receptor 1 MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLA VADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKIS NRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSAR IIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITL SFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSG EPWSPSYLGPTSP",GPR109A,G-protein coupled receptor 109A; G-protein coupled receptor HM74A,363,41850,9.37,">>> Function: nucleotide receptor activity, G-protein coupled Function: purinergic nucleotide receptor activity, G-protein coupled Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:24827,Cell membrane,,"","",None,"34-54 64-84 103-123 143-163 193-213 230-250 274-294",Non Essential,"",GPR109A,NIACR1,BC056419,"","" 1228,Nicotinamide N-methyltransferase,2009-07-22 22:36:16 UTC,2009-08-13 06:39:41 UTC,P40261,Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds,"",">Nicotinamide N-methyltransferase MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQ LLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLK CDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQK FSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL",NNMT,"",264,29574,5.45,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF01234:NNMT_PNMT_TEMT,HGNC:7861,Cytoplasm,,"","",None,None,Non Essential,"",NNMT,NNMT,BC000234,"","" 1229,Nicotinate-nucleotide pyrophosphorylase [carboxylating],2009-07-22 22:36:16 UTC,2009-08-13 06:39:29 UTC,Q15274,"Nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1- diphosphate","",">Nicotinate-nucleotide pyrophosphorylase [carboxylating] MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQ VSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKT TPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQ AAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALD FSLKLFAKEVAPVPKIH",QPRT,Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase,297,30816,6.15,">>> Function: nicotinate-nucleotide diphosphorylase (carboxylating) activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring pentosyl groups Function: nicotinate-nucleotide diphosphorylase (carboxylating) activity || >>> Process: NAD biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: cofactor metabolism Process: coenzyme metabolism Process: coenzyme biosynthesis Process: pyridine nucleotide biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,"PF01729:QRPTase_C PF02749:QRPTase_N",HGNC:9755,"",,"","",None,None,Non Essential,"",QPRT,QPRT,BC018910,"","" 1230,Nicotinic acid receptor 2,2009-07-22 22:36:16 UTC,2009-08-13 06:39:31 UTC,P49019,Acts as a low affinity receptor for nicotinic acid and mediate its anti-lipolytic effect through a G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet,"",">Nicotinic acid receptor 2 MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLA VADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKIS NWTAAIISCLLWGITVGLTVHLLKKKLLIQNGPANVCISFSICHTFRWHEAMFLLEFLLPLGIILFCSAR IIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITL SFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSG EPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE",GPR109B,G-protein coupled receptor 109B; G-protein coupled receptor HM74B; G-protein coupled receptor HM74,387,44496,9.01,">>> Function: nucleotide receptor activity, G-protein coupled Function: purinergic nucleotide receptor activity, G-protein coupled Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:16824,Cell membrane,,"","",None,"29-50 64-85 103-123 143-163 195-209 237-256 274-298",Non Essential,"",GPR109B,NIACR2,BC047891,"","" 1231,Cytochrome P450 3A3,2009-07-22 22:36:17 UTC,2009-07-22 22:36:17 UTC,P05184,,,,,,,,,,,,,,,,,,,,,,,,, 1232,Adenosine A3 receptor,2009-07-22 22:36:18 UTC,2009-08-13 06:39:49 UTC,P33765,Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction,"",">Adenosine A3 receptor MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAI VVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFL VGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSL NLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPI VYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE",ADORA3,"",318,36185,9.04,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: nucleotide receptor activity, G-protein coupled Function: purinergic nucleotide receptor activity, G-protein coupled Function: adenosine receptor activity, G-protein coupled Function: A3 adenosine receptor activity, G-protein coupled || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:268,Cell membrane,,"","",None,"15-37 49-72 85-106 127-148 178-198 232-255 262-284",Non Essential,"",ADORA3,ADORA3,AY011231,"","" 1233,Cytochrome P450 51,2009-07-22 22:36:18 UTC,2009-08-13 06:39:33 UTC,P10613,"Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol","",">Cytochrome P450 51 MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAASYGQQPYE FFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLM EQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMR RIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSL LIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLND LTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPE DFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN LRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKRETCMF",ERG11,CYPLI; P450-LIA1; Sterol 14-alpha demethylase; Lanosterol 14-alpha demethylase; P450-14DM,528,60676,7.19,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,"",Membrane (Potential). Membrane,,"","",None,None,Essential,"",ERG11,"",U67193,"","" 1234,Thymidylate synthase,2009-07-22 22:36:18 UTC,2009-08-13 06:39:38 UTC,P04818,"5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP","",">Thymidylate synthase MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDE FPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWR HFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSC QLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLR ILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV",TYMS,TSase; TS,313,35716,7.00,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity Function: thymidylate synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: pyrimidine nucleotide metabolism Process: pyrimidine nucleotide biosynthesis Process: pyrimidine nucleoside monophosphate biosynthesis Process: pyrimidine deoxyribonucleoside monophosphate biosynthesis Process: dTMP biosynthesis || >>> Component: Not Available",Nucleotide transport and metabolism,PF00303:Thymidylat_synt,HGNC:12441,"",,"","",None,None,Non Essential,1JUJ,TYMS,TYMS,D00517,"","" 1235,Metabotropic glutamate receptor 5,2009-07-22 22:36:21 UTC,2009-08-13 06:39:58 UTC,P41594,Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current,"",">Metabotropic glutamate receptor 5 MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVE AMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSK KPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYN WTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEG MTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNH RNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNG ELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTD DLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYL CTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFIL ICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNE AKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS TVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSS NGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGA GCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARS SSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPA IEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALC IPSSPKYDTLIIRDYTQSSSSL",GRM5,mGluR5,1212,132470,7.82,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: metabotropic glutamate, GABA-B-like receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF00003:7tm_3 PF01094:ANF_receptor PF07562:NCD3G",HGNC:4597,Cell membrane,,"","",1-20,"580-602 617-637 649-667 694-714 738-759 773-795 802-827",Non Essential,"",GRM5,GRM5,S64316,"","" 1236,Metabotropic glutamate receptor 1,2009-07-22 22:36:21 UTC,2009-08-13 06:39:39 UTC,Q13255,"Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum","",">Metabotropic glutamate receptor 1 MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEI REQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRC LPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTL QARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRER LPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSF DDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEAN RYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEF TCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSREL CYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRF MSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYY AFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMW HRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPSMVVHR RVPSAATTPPLPPHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTAIPDFHA VLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTE EDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQS SSTL",GRM1,mGluR1,1194,132368,6.67,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: metabotropic glutamate, GABA-B-like receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF00003:7tm_3 PF01094:ANF_receptor PF07562:NCD3G",HGNC:4593,Cell membrane,,"","",1-18,"593-615 630-650 662-680 707-727 751-772 786-808 815-840",Non Essential,1ISS,GRM1,GRM1,AL035698,"","" 1237,Gonadotropin-releasing hormone II receptor,2009-07-22 22:36:22 UTC,2009-08-13 06:39:33 UTC,Q96P88,Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (Potential),"",">Putative gonadotropin-releasing hormone II receptor MSAGNGTPWGSAAGEEVWAGSGVEVEGSELPTFSAAAKVRVGVTIVLFVSSAGGNLAVLWSVTRREPSQL RPSPVRRLFIHLAAADLLVTFVVMPLDATWNITVQWLAVDIACRTLMFLKLMATYSAAFLPVVIGLDRQA AVLNPLGSRSGVRKLLGAAWGLSFLLAFPQLFLFHTVH",GNRHR2,Type II GnRH receptor; GnRH-II-R,178,19031,10.11,">>> Function: protein-hormone receptor activity Function: gonadotropin-releasing hormone receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:16341,Cell membrane,,"","",None,"41-61 78-98 116-136 155-175",Non Essential,"",GNRHR2,GNRHR2,AY081843,"","" 1239,Multidrug resistance-associated protein 1,2009-07-22 22:36:26 UTC,2009-08-13 06:40:00 UTC,P33527,May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Confers resistance to anticancer drugs. Transports LTC4. May protect milk against xenobiotics (By similarity),"",">Multidrug resistance-associated protein 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPL NKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITTLLATFLIQLERRKGVQSSGIMLT FWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPE SSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSK DPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLI KFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLV ALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSI ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG HVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSG GQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQL QRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIF LFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIP PLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYY PSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTG AGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVW TSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQS TIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV",ABCC1,ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter,1531,171563,7.11,">>> Function: transporter activity Function: ATPase activity Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: ATPase activity, coupled to transmembrane movement of substances Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: binding Function: nucleotide binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Defense mechanisms,"PF00664:ABC_membrane PF00005:ABC_tran",HGNC:51,Membrane,,"","",None,"34-54 75-95 101-121 134-154 173-193 317-337 364-384 441-461 465-485 548-568 591-611 968-988 1026-1046 1090-1110 1112-1132 1204-1224 1227-1247",Non Essential,"",ABCC1,ABCC1,AC003026,"","" 1240,Alpha-2B adrenergic receptor,2009-07-22 22:36:27 UTC,2009-08-13 06:40:01 UTC,P18089,"Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol","",">Alpha-2B adrenergic receptor MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSL ANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIA AVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAK GGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNS GQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVG AIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS LNPVIYTIFNQDFRRAFRRILCRPWTQTAW",ADRA2B,Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2 adrenergic receptor subtype C2,450,49954,8.52,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: adrenoceptor activity Function: alpha-adrenergic receptor activity Function: alpha2-adrenergic receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:282,Cell membrane,,"","",None,"13-38 50-75 86-108 131-153 170-193 373-396 406-429",Non Essential,1HOF,ADRA2B,ADRA2B,M38742,"","" 1241,HIV-1 protease,2009-07-22 22:36:27 UTC,2009-08-13 06:39:27 UTC,O90777,"","",">HIV-1 protease PQVTLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYDQVSIEICGHK AIGTVLIGPTPVNIIGRNLLTQLGCTLNF",HIV-1 protease,"",99,10725,8.77,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: aspartic-type endopeptidase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis || >>> Component: Not Available","",PF00077:RVP,"",Cytoplasmic,,"","",None,None,Non Essential,1ODW,HIV-1 protease,"",AJ010714,"","" 1242,D(1B) dopamine receptor,2009-07-22 22:36:29 UTC,2009-08-13 06:39:38 UTC,P21918,This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase,"",">D(1B) dopamine receptor MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRH LRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYW AISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEP DVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAP DTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWA NSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH",DRD5,D1beta dopamine receptor; D(5) dopamine receptor,477,52951,5.08,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: dopamine receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:3026,Cell membrane,,"","",None,"40-66 78-104 115-136 159-180 224-246 297-320 341-360",Non Essential,"",DRD5,DRD5,BC009748,"","" 1243,Squalene monooxygenase,2009-07-22 22:36:32 UTC,2009-08-13 06:39:28 UTC,Q14534,Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway,"",">Squalene monooxygenase MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQRSGSQFALFSDIL SGLPFIGFFWAKSPPESENKEQLGARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALVA VLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPY PLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPL TVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYRISSSETRVLVDIRG EMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMLASFLPPSSVKKRGVLLLGDAYNMRHPLTGGG MTVAFKDIKLWRKLLKGIPDLYDDAAIFEANKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKA CFLYFKLGGECVAGPVGLLSVLSPNPLALIGHFFAVAIYAVYFCFKSEPWITKPRALLSSSAVLYKACSV IFPLIYSEMKYMVH",SQLE,Squalene epoxidase; SE,574,63940,9.12,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Coenzyme transport and metabolism,"PF01266:DAO PF08491:SE",HGNC:11279,Microsome membrane,,"","",None,"20-40 61-81 123-143 546-566",Non Essential,"",SQLE,SQLE,D78129,"","" 1244,Retinoic acid receptor RXR-beta,2009-07-22 22:36:36 UTC,2009-08-13 06:39:34 UTC,P28702,Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA),"",">Retinoic acid receptor RXR-beta MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQTPEPEPGEAGR DGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSM GSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGD RSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQ RGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTL VEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLL LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA",RXRB,Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2,533,56922,8.24,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","Cell cycle control, cell division, chromosome partitioning","PF00104:Hormone_recep PF00105:zf-C4",HGNC:10478,Nucleus,,"","",None,None,Non Essential,1UHL,RXRB,RXRB,BC001167,"","" 1245,Retinoic acid receptor gamma-2,2009-07-22 22:36:37 UTC,2009-07-22 22:36:37 UTC,P22932,,,,,,,,,,,,,,,,,,,,,,,,, 1246,Retinoic acid-induced protein 3,2009-07-22 22:36:37 UTC,2009-08-13 06:39:46 UTC,Q8NFJ5,Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways,"",">Retinoic acid-induced protein 3 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFL FLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVG FSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHG AHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVE DAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDY EVKKEGS",GPRC5A,G-protein coupled receptor family C group 5 member A; Retinoic acid-induced gene 1 protein; RAIG-1; Orphan G-protein-coupling receptor PEIG-1,357,40252,8.26,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: metabotropic glutamate, GABA-B-like receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","",PF00003:7tm_3,HGNC:9836,Cell membrane,,"","",None,"34-54 69-89 98-118 130-150 177-197 213-233 248-268",Non Essential,"",GPRC5A,GPRC5A,BC003665,"","" 1247,Retinoic acid receptor RXR-gamma,2009-07-22 22:36:37 UTC,2009-08-13 06:39:56 UTC,P48443,Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA) (By similarity),"",">Retinoic acid receptor RXR-gamma MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPY RVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICA ICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQ EERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTL VEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRV LTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT",RXRG,Retinoid X receptor gamma; Nuclear receptor subfamily 2 group B member 3,463,50872,7.67,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:10479,Nucleus (By similarity),,"","",None,None,Non Essential,"",RXRG,RXRG,BC012063,"","" 1248,Nuclear receptor 0B1,2009-07-22 22:36:37 UTC,2009-08-13 06:39:52 UTC,P51843,Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity),"",">Nuclear receptor subfamily 0 group B member 1 MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNVALLYRCCFCG KDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRAGLPGGRPVALLYRCCFCGEDHP RQGSILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQRPGGKEALPGGRATALLYRCCFCGEDHPQQG STLYCVPTSTNQAQAAPEERPRAPWWDTSSGALRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPL DQQLVLVRNCWASLLMLELAQDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQHHLAPPAEAR KVPSASQVQAIKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQ GPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI",NR0B1,Nuclear receptor DAX-1; DSS-AHC critical region on the X chromosome protein 1,470,51718,8.12,">>> Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","",PF00104:Hormone_recep,HGNC:7960,Nucleus. Cytoplasm,,"","",None,None,Non Essential,"",NR0B1,NR0B1,BC011564,"","" 1249,Retinoic acid receptor responder protein 1,2009-07-22 22:36:38 UTC,2009-08-13 06:39:58 UTC,P49788,"","",">Retinoic acid receptor responder protein 1 MQPRRQRLPAPWSGPRGPRPTAPLLALLLLLAPVAAPAGSGDPDDPGQPQDAGVPRRLLQQAARAALHFF NFRSGSPSALRVLAEVQEGRAWINPKEGCKVHVVFSTERYNPESLLQEGEGRLGKCSARVFFKNQKPRPT INVTCTRLIEKKKRQQEDYLLYKQMKQLKNPLEIVSIPDNHGHIDPSLRLIWDLAFLGSSYVMWEMTTQV SHYYLAQLTSVRQWKTNDDTIDFDYTVLLHELSTQEIIPCRIHLVWYPGKPLKVKYHCQELQTPEEASGT EEGSAVVPTELSNF",RARRES1,RAR-responsive protein TIG1; Tazarotene-induced gene 1 protein,294,33285,8.69,"","",PF06907:Latexin,HGNC:9867,Membrane,,"","",None,21-42,Non Essential,"",RARRES1,RARRES1,BC029640,"","" 1250,Protein S100-A1,2009-07-22 22:36:39 UTC,2009-08-13 06:39:45 UTC,P23297,"Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites","",">Protein S100-A1 MGSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSGFLDAQKDVDAVDKVMKELDENGDGEV DFQEYVVLVAALTVACNNFFWENS",S100A1,S100 calcium-binding protein A1; S-100 protein alpha subunit; S-100 protein alpha chain,94,10546,4.13,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: Not Available || >>> Component: Not Available","","PF00036:efhand PF01023:S_100",HGNC:10486,Cytoplasm,,"","",None,None,Non Essential,1K2H,S100A1,S100A1,BC014392,"","" 1251,Membrane copper amine oxidase,2009-07-22 22:36:41 UTC,2009-08-13 06:39:54 UTC,Q16853,Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity,"",">Membrane primary amine oxidase MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTA VMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQPNVSE LVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLLHHCCFYKHRGRNLVT MTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQ FEAGLVNVVLIPDNGTGGSWSLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIF DVRFQGERLVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFHPSGAIEIRFY ATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVWAEDMVFVPMAVPWSPEHQLQ RLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERY QLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNG VGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN",AOC3,Copper amine oxidase; Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; HPAO,763,84623,6.51,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: copper ion binding || >>> Process: Not Available || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism","PF01179:Cu_amine_oxid PF02727:Cu_amine_oxidN2 PF02728:Cu_amine_oxidN3",HGNC:550,Membrane,,"","",None,6-26,Non Essential,1PU4,AOC3,AOC3,BC050549,"","" 1252,"Acetyl-CoA acetyltransferase, mitochondrial",2009-07-22 22:36:42 UTC,2009-08-13 06:39:44 UTC,P24752,Plays a major role in ketone body metabolism,"",">Acetyl-CoA acetyltransferase, mitochondrial MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLSLLPATKLGSI AIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCTTINKVCASGMKAIMMASQSL MCGHQDVMVAGGMESMSNVPYVMNRGSTPYGGVKLEDLIVKDGLTDVYNKIHMGSCAENTAKKLNIARNE QDAYAINSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTA ANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMW EVNEAFSLVVLANIKMLEIDPQKVNINGGAVSLGHPIGMSGARIVGHLTHALKQGEYGLASICNGGGGAS AMLIQKL",ACAT1,Acetoacetyl-CoA thiolase; T2,427,45200,9.21,"",Lipid transport and metabolism,"PF02803:Thiolase_C PF00108:Thiolase_N",HGNC:93,Mitochondrion,,"","",None,None,Non Essential,"",ACAT1,ACAT1,D10511,"","" 1253,Cystine/glutamate transporter,2009-07-22 22:36:42 UTC,2009-08-13 06:39:57 UTC,Q9UPY5,"Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate","",">Cystine/glutamate transporter MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVL QNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATA VISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGV MQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIG YVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGH LPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRP FKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIMSEKITRTLQI ILEVVPEEDKL",SLC7A11,Amino acid transport system xc-; xCT; Solute carrier family 7 member 11; Calcium channel blocker resistance protein CCBR1,501,55424,9.51,">>> Function: amino acid permease activity Function: transporter activity Function: amine transporter activity Function: amino acid transporter activity Function: amino acid-polyamine transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: amine transport Process: amino acid transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Amino acid transport and metabolism,PF00324:AA_permease,HGNC:11059,Membrane,,"","",None,"44-64 75-95 114-134 159-179 190-210 235-255 266-286 318-338 365-385 388-408 423-443 450-470",Non Essential,"",SLC7A11,SLC7A11,BC012087,"","" 1254,Alpha-1-acid glycoprotein 1,2009-07-22 22:36:42 UTC,2009-08-13 06:39:45 UTC,P02763,Appears to function in modulating the activity of the immune system during the acute-phase reaction,"",">Alpha-1-acid glycoprotein 1 MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDQITGKWFYIASAFRNEEYNKSVQEIQATFFYFT PNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLLILRDTKTYMLAFDVNDEKNW GLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKKDKCEPLEKQHEKERKQEEGES",ORM1,AGP 1; Orosomucoid-1; OMD 1,201,23512,4.66,">>> Function: transporter activity Function: binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available","",PF00061:Lipocalin,HGNC:8498,Secreted,,"","",1-18,None,Non Essential,"",ORM1,ORM1,BC026238,"","" 1255,Carbonic anhydrase 14,2009-07-22 22:36:46 UTC,2009-08-13 06:39:50 UTC,Q9WVT6,Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 14 MLFFALLLKVTWILAADGGHHWTYEGPHGQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYD QLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQLHLHWGQRGSLEGSEHQINSEATAAELHVVHYD SQSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYKDQKTSVPPFSVRELFPQQLEQFF RYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFASFIQ AGPLYTTGEMLGLGVGILAGCLCLLLAVYFIAQKIRKKRLGNRKSVVFTSARATTEA",Ca14,Carbonic anhydrase XIV; CA-XIV; Carbonate dehydratase XIV,337,37506,6.34,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,"",Membrane,,"","",1-15,291-311,Essential,1RJ6,Ca14,"",BC046995,"","" 1256,"Gamma-aminobutyric acid type B receptor, subunit 1",2009-07-22 22:36:48 UTC,2009-08-13 06:39:44 UTC,Q9UBS5,Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites,"",">Gamma-aminobutyric acid type B receptor subunit 1 MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGE REVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGS SRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYE LKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRF PTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVP VKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVE GHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGR SGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDL SWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLN NLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKE WRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWL GIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLA IVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVS ELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK",GABBR1,GABA-B receptor 1; GABA-B-R1; Gb1,961,108321,8.30,">>> Function: GABA-B receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: metabotropic glutamate, GABA-B-like receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF00003:7tm_3 PF01094:ANF_receptor PF00084:Sushi",HGNC:4070,Isoform 1E:Secreted (Probable),,"","",1-14,"592-612 632-652 668-688 711-731 769-789 805-825 834-854",Non Essential,1SS2,GABBR1,GABBR1,BC050532,"","" 1257,Sex hormone-binding globulin,2009-07-22 22:36:51 UTC,2009-08-13 06:39:58 UTC,P04278,"Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration","",">Sex hormone-binding globulin MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTS SSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDS VLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASA PTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLH LQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLG ALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH",SHBG,SHBG; Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estrogen-binding globulin; Testosterone-estradiol-binding globulin; TeBG,402,43780,6.70,"","",PF00054:Laminin_G_1,HGNC:10839,Secreted (By similarity),,"","",1-29,None,Non Essential,1F5F,SHBG,SHBG,X05792,"","" 1258,NADPH--cytochrome P450 reductase,2009-07-22 22:36:52 UTC,2009-08-13 06:39:52 UTC,P16435,This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5,"",">NADPH--cytochrome P450 reductase MGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKIQTLTSSVRESSFV EKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATY GEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDG NLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKN PFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNN LDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWV VEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVA TNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGET LLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCG DARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS",POR,CPR; P450R,677,76691,5.28,">>> Function: binding Function: nucleotide binding Function: FMN binding Function: transporter activity Function: electron transporter activity Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Inorganic ion transport and metabolism,"PF00667:FAD_binding_1 PF00258:Flavodoxin_1 PF00175:NAD_binding_1",HGNC:9208,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,1AMO,POR,POR,AB051763,"","" 1259,FK506-binding protein 1A,2009-07-22 22:36:53 UTC,2009-08-13 06:39:38 UTC,P62942,"May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides","",">Peptidyl-prolyl cis-trans isomerase FKBP1A MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVG QRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE",FKBP1A,PPIase FKBP1A; FK506-binding protein 1A; FKBP-1A; Rotamase; Immunophilin FKBP12; 12 kDa FKBP; FKBP-12,108,11951,8.48,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein folding || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00254:FKBP_C,HGNC:3711,Cytoplasm,,"","",None,None,Non Essential,1J4I,FKBP1A,FKBP1A,BC005147,"","" 1260,Glycine receptor subunit alpha-2,2009-07-22 22:36:53 UTC,2009-08-13 06:40:00 UTC,P23416,The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing),"",">Glycine receptor subunit alpha-2 MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPP VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGA NFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPV QVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINM DAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLR LRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDT ISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK",GLRA2,"",452,52003,9.20,">>> Function: neurotransmitter receptor activity Function: anion channel activity Function: chloride channel activity Function: glycine-gated chloride channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4327,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-27,"254-280 287-304 319-342 424-441",Non Essential,"",GLRA2,GLRA2,U77731,"","" 1261,5-hydroxytryptamine 6 receptor,2009-07-22 22:36:54 UTC,2009-08-13 06:39:35 UTC,P50406,"This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs","",">5-hydroxytryptamine receptor 6 MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFT SDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTP LRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCR ILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVT WLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLAS PSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF FNIDPAEPELRPHPLGIPTN",HTR6,5-HT-6; Serotonin receptor 6,440,46955,9.02,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:5301,Cell membrane,,"","",None,"35-57 65-85 101-122 145-166 185-208 266-290 296-320",Non Essential,"",HTR6,HTR6,Z49119,"","" 1262,Sodium- and chloride-dependent GABA transporter 1,2009-07-22 22:36:54 UTC,2009-08-13 06:39:37 UTC,P30531,Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals,"",">Sodium- and chloride-dependent GABA transporter 1 MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRF PYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYY IVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQI RWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLS DSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTK RSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR ELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGS RPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLALK GSLKQRIQVMVQPSEDTVRPENGPEHAQAGSSTSKEAYI",SLC6A1,GAT-1; Solute carrier family 6 member 1,599,67015,8.16,">>> Function: organic acid transporter activity Function: organic acid:sodium symporter activity Function: sodium:amino acid symporter activity Function: gamma-aminobutyric acid:sodium symporter activity Function: transporter activity Function: neurotransmitter transporter activity Function: neurotransmitter:sodium symporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: neurotransmitter transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane Component: integral to plasma membrane","",PF00209:SNF,HGNC:11042,Cell membrane,,"","",None,"53-73 81-100 124-144 212-230 239-256 292-309 321-342 375-394 422-440 457-477 498-517 536-554",Non Essential,"",SLC6A1,SLC6A1,X54673,"","" 1263,Matrix protein 2,2009-07-22 22:36:57 UTC,2009-08-13 06:39:41 UTC,P21430,"Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity)","",">Matrix protein 2 MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDHLFFKCIYRFFKHGLKRGPSTEGVPE SMREEYRKEQQSAVDADDSHFVSIELE",M,Proton channel protein M2,97,11166,4.87,"","",PF00599:Flu_M2,"",Virion membrane (By similarity). Apical cell membrane,,"","",None,23-43,Essential,1NYJ,M,"",M23978,"","" 1264,Phospholipase A2 isoform 3,2009-07-22 22:36:59 UTC,2009-08-13 06:39:52 UTC,P60045,PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides,"",">Phospholipase A2 isoform 3 SNRPMPLNLYQFKNMIQCTVPSRSWQDFADYGCYCGKGGSGTPVDDLDRCCQVHDNCYNEAENISGCRPY FKTYSYECTQGTLTCKGDNNACAASVCDCDRLAAICFAGAPYNDANYNIDLKARCN","",Phosphatidylcholine 2-acylhydrolase; Fragment,126,13969,4.74,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: carboxylic ester hydrolase activity Function: lipase activity Function: phospholipase activity Function: phospholipase A2 activity || >>> Process: physiological process Process: metabolism Process: primary metabolism Process: lipid metabolism Process: lipid catabolism || >>> Component: Not Available","",PF00068:Phospholip_A2_1,"",Secreted,,"","",None,None,Essential,1YXL,"","",AY433936,"","" 1265,Melatonin receptor type 1B,2009-07-22 22:37:02 UTC,2009-08-13 06:39:54 UTC,P49286,High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity,"",">Melatonin receptor type 1B MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRK LRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYC YICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFL LPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQE MAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAP PIIGVQHQADAL",MTNR1B,Mel1b melatonin receptor; Mel-1B-R,362,40189,8.91,">>> Function: melatonin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:7464,Cell membrane,,"","",None,"43-63 77-97 116-136 156-176 201-221 254-274 288-308",Non Essential,"",MTNR1B,MTNR1B,BC069163,"","" 1266,Melatonin receptor type 1A,2009-07-22 22:37:03 UTC,2009-08-13 06:40:00 UTC,P48039,High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity,"",">Melatonin receptor type 1A MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLA VADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYS SKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRI WILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVAS YYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV",MTNR1A,Mel1a melatonin receptor; Mel-1A-R,350,39375,9.75,">>> Function: melatonin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:7463,Cell membrane,,"","",None,"30-50 64-84 103-123 143-163 188-208 241-261 275-295",Non Essential,"",MTNR1A,MTNR1A,BC126299,"","" 1267,"Calcium channel, voltage-dependent, L type, alpha 1B subunit",2009-07-22 22:37:04 UTC,2009-07-22 22:37:04 UTC,Q5SQC4,,,,,,,,,,,,,,,,,,,,,,,,, 1268,NADPH azoreductase,2009-07-22 22:37:06 UTC,2009-08-13 06:39:30 UTC,Q9FAW5,"Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADPH as an electron donor for its activity. Compounds with paired naphthalene groups coupled with the azo group are good substrates, with the following preference order:Rocceline > Sumifix Black B > Solar Orange","",">NADPH azoreductase MKLVVINGTPRKFGRTRVVAKYIADQFEGELYDLAIEELPLYNGEESQRDLEAVKKLKTLVKAADGVVLC TPEYHNAMSGALKNSLDYLSSSEFIHKPVALLAVAGGGKGGINALNSMHASLAGVYANAIPKQVVLDGLH VQDGELGEDAKPLIHDVVKELKAYMSVYKEVKKQLGVE",azr,"",178,19294,6.68,"","",PF03358:FMN_red,"","",,"","",None,None,Essential,"",azr,"",AB032601,"","" 1269,Osteocalcin,2009-07-22 22:37:06 UTC,2009-08-13 06:40:00 UTC,P02818,Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium,"",">Osteocalcin MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPR REVCELNPDCDELADHIGFQEAYRRFYGPV",BGLAP,Gamma-carboxyglutamic acid-containing protein; Bone Gla protein; BGP,100,10963,7.18,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of organismal physiological process Process: regulation of bone remodeling Process: regulation of ossification Process: regulation of bone mineralization || >>> Component: extracellular region","",PF00594:Gla,HGNC:1043,Secreted,,"","",1-23,None,Non Essential,"",BGLAP,BGLAP,BC113434,"","" 1270,Inosine-5'-monophosphate dehydrogenase 2,2009-07-22 22:37:06 UTC,2009-08-13 06:39:42 UTC,P12268,Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors,"",">Inosine-5'-monophosphate dehydrogenase 2 MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPM DTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFC GIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLP IVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNS IFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKV SEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKF EKRTSSAQVEGGVHSLHSYEKRLF",IMPDH2,IMP dehydrogenase 2; IMPDH-II; IMPD 2,514,55806,6.90,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on CH-OH group of donors Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function: IMP dehydrogenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: purine nucleotide metabolism Process: purine nucleotide biosynthesis Process: purine nucleoside monophosphate biosynthesis Process: purine ribonucleoside monophosphate biosynthesis Process: GMP biosynthesis || >>> Component: Not Available",Nucleotide transport and metabolism,"PF00571:CBS PF00478:IMPDH",HGNC:6053,"",,"","",None,None,Non Essential,1NFB,IMPDH2,IMPDH2,L08114,"","" 1271,Inosine-5'-monophosphate dehydrogenase 1,2009-07-22 22:37:06 UTC,2009-08-13 06:39:47 UTC,P20839,Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors,"",">Inosine-5'-monophosphate dehydrogenase 1 MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPM DTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKMRHGFS GIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLP IVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNS VYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKV AEYARRFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKF EKRTMSAQIEGGVHGLHSYEKRLY",IMPDH1,IMP dehydrogenase 1; IMPDH-I; IMPD 1,514,55407,6.90,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on CH-OH group of donors Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function: IMP dehydrogenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: purine nucleotide metabolism Process: purine nucleotide biosynthesis Process: purine nucleoside monophosphate biosynthesis Process: purine ribonucleoside monophosphate biosynthesis Process: GMP biosynthesis || >>> Component: Not Available",Nucleotide transport and metabolism,"PF00571:CBS PF00478:IMPDH",HGNC:6052,"",,"","",None,None,Non Essential,1JCN,IMPDH1,IMPDH1,BC033622,"","" 1272,Inosine-5'-monophosphate dehydrogenase,2009-07-22 22:37:07 UTC,2009-08-13 06:39:41 UTC,P50097,Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth,"",">Inosine-5'-monophosphate dehydrogenase MAKYYNEPCHTFNEYLLIPGLSTVDCIPSNVNLSTPLVKFQKGQQSEINLKIPLVSAIMQSVSGEKMAIA LAREGGISFIFGSQSIESQAAMVHAVKNFKAGFVVSDSNVKPDQTFADVLAISQRTTHNTVAVTDDGTPH GVLLGLVTQRDYPIDLTQTETKVSDMMTPFSKLVTAHQDTKLSEANKIIWEKKLNALPIIDDDQHLRYIV FRKDYDRSQVCHNELVDSQKRYLVGAGINTRDFRERVPALVEAGADVLCIDSSDGFSEWQKITIGWIREK YGDKVKVGAGNIVDGEGFRYLADAGADFIKIGIGGGSICITREQKGIGRGQATAVIDVVAERNKYFEETG IYIPVCSDGGIVYDYHMTLALAMGADFIMLGRYFARFEESPTRKVTINGSVMKEYWGEGSSRARNWQRYD LGGKQKLSFEEGVDSYVPYAGKLKDNVEASLNKVKSTMCNCGALTIPQLQSKAKITLVSSVSIVEGGAHD VIVKDRINDYHPK",IMPDH,IMP dehydrogenase; IMPDH; IMPD,503,55474,6.67,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on CH-OH group of donors Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function: IMP dehydrogenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: purine nucleotide metabolism Process: purine nucleotide biosynthesis Process: purine nucleoside monophosphate biosynthesis Process: purine ribonucleoside monophosphate biosynthesis Process: GMP biosynthesis || >>> Component: Not Available",Nucleotide transport and metabolism,"PF00571:CBS PF00478:IMPDH","","",,"","",None,None,Essential,1MEW,IMPDH,"",L18917,"","" 1273,Inosine-5'-monophosphate dehydrogenase 2,2009-07-22 22:37:07 UTC,2009-08-13 06:39:48 UTC,P12269,Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors,"",">Inosine-5'-monophosphate dehydrogenase 2 MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPM DTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFC GIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLP IVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNS IFQINMIKYMKEKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGCGSICITQEVLACGRPQATAVYKV SEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKF EKRTSSAQVEGGVHSLHSYEKRLF",IMPDH2,IMP dehydrogenase 2; IMPDH-II; IMPD 2,514,55891,7.30,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on CH-OH group of donors Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function: IMP dehydrogenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: purine nucleotide metabolism Process: purine nucleotide biosynthesis Process: purine nucleoside monophosphate biosynthesis Process: purine ribonucleoside monophosphate biosynthesis Process: GMP biosynthesis || >>> Component: Not Available",Nucleotide transport and metabolism,"PF00571:CBS PF00478:IMPDH","","",,"","",None,None,Essential,1JR1,IMPDH2,"",J04209,"","" 1274,Cytochrome b5,2009-07-22 22:37:08 UTC,2009-08-13 06:39:45 UTC,P00167,Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases,"",">Cytochrome b5 MAEQSDEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVGHST DAREMSKTFIIGELHPDDRPKLNKPPETLITTIDSSSSWWTNWVIPAISAVAVALMYRLYMAED",CYB5A,"",134,15330,4.61,"","",PF00173:Cyt-b5,HGNC:2570,Isoform 2:Cytoplasm,,"","",None,109-131,Non Essential,1HKO,CYB5A,CYB5A,M60174,"","" 1275,3-oxoacyl-[acyl-carrier-protein] synthase 3,2009-07-22 22:37:09 UTC,2009-08-13 06:40:01 UTC,P0A6R0,Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain,"",">3-oxoacyl-[acyl-carrier-protein] synthase 3 MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEK DQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSD VLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGN EVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASV PCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF",fabH,3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III; EcFabH,317,33515,4.89,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity Function: fatty-acid synthase activity Function: 3-oxoacyl-[acyl-carrier protein] synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: organic acid metabolism Process: carboxylic acid metabolism Process: fatty acid metabolism Process: fatty acid biosynthesis || >>> Component: Not Available",Lipid transport and metabolism,"PF08545:ACP_syn_III PF08541:ACP_syn_III_C","",Cytoplasm,,"","",None,None,Essential,1HNK,fabH,"",Z11565,"","" 1276,3-oxoacyl-[acyl-carrier-protein] synthase 2,2009-07-22 22:37:09 UTC,2009-08-13 06:39:45 UTC,P0AAI5,Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis,"",">3-oxoacyl-[acyl-carrier-protein] synthase 2 MSKRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCEDIISRKEQRK MDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHTSLMNGGPRKISPFFVPSTIV NMVAGHLTIMYGLRGPSISIATACTSGVHNIGHAARIIAYGDADVMVAGGAEKASTPLGVGGFGAARALS TRNDNPQAASRPWDKERDGFVLGDGAGMLVLEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGA ALAMANALRDAGIEASQIGYVNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVE SIYSILALRDQAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI",fabF,3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II,413,43046,6.00,">>> Function: catalytic activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: organic acid metabolism Process: carboxylic acid metabolism Process: fatty acid metabolism Process: fatty acid biosynthesis || >>> Component: Not Available",Lipid transport and metabolism,"PF00109:ketoacyl-synt PF02801:Ketoacyl-synt_C","","",,"","",None,None,Essential,1KAS,fabF,"",AP009048,"","" 1277,3-oxoacyl-[acyl-carrier-protein] synthase 1,2009-07-22 22:37:09 UTC,2009-08-13 06:39:49 UTC,P0A953,Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids,"",">3-oxoacyl-[acyl-carrier-protein] synthase 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLIDRKVVRFMSD ASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMAS GVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTK YNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRC MKMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLML EHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD",fabB,3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I,406,42614,5.25,">>> Function: catalytic activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: organic acid metabolism Process: carboxylic acid metabolism Process: fatty acid metabolism Process: fatty acid biosynthesis || >>> Component: Not Available",Lipid transport and metabolism,"PF00109:ketoacyl-synt PF02801:Ketoacyl-synt_C","",Cytoplasm,,"","",None,None,Essential,1G5X,fabB,"",AP009048,"","" 1278,Fatty acid synthase,2009-07-22 22:37:09 UTC,2009-08-13 06:39:56 UTC,P49327,"Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein","",">Fatty acid synthase MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRFDASFFGVHPK QAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMM ANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEG TCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSA GVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEH GLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATL PRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGPEVQQVPAGER PLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQ IGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEEC KQRCPPGVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKK VIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAV LKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSL AWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQL PVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPT EPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPT RVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFT PHTEEGCLSERAALQEELQLCKGLVQALQTTVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQL NGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLL SPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALS NMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTL FLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLR CVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGD LSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASG KRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGV GQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAE EKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRD GVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIA GGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAA QLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAG QSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLN QPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLEREL NLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSS ERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYG ACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEH NRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKT GGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG",FASN,[Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; Enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase,2511,273403,6.39,">>> Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: vitamin binding Function: phosphopantetheine binding Function: binding Function: cofactor binding Function: oxidoreductase activity Function: catalytic activity Function: transferase activity || >>> Process: biosynthesis Process: cellular metabolism Process: organic acid metabolism Process: carboxylic acid metabolism Process: fatty acid metabolism Process: fatty acid biosynthesis Process: physiological process Process: metabolism || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism","PF00698:Acyl_transf_1 PF00106:adh_short PF00107:ADH_zinc_N PF00109:ketoacyl-synt PF02801:Ketoacyl-synt_C PF08242:Methyltransf_12 PF00550:PP-binding PF00975:Thioesterase",HGNC:3594,Cytoplasm. Melanosome,,"","",None,None,Non Essential,1XKT,FASN,FASN,BC063242,"","" 1279,DNA-directed RNA polymerase beta chain,2009-07-22 22:37:11 UTC,2009-08-13 06:39:48 UTC,P0A8V2,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates,"",">DNA-directed RNA polymerase subunit beta MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQSYSGNSELQY VSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEIPLMTDNGTFVING TERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIIL RALNYTTEQILDLFFEKVIFEIRDNKLQMELVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKD DVKLIEVPVEYIAGKVVAKDYIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISET LRVDPTNDRLSALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLREEIEGSGIL SKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQ DMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCP IETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVTDEIHYLSAIEEGNYVIAQANSNLDEEGHFV EDLVTCRSKGESSLFSRDQVDYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLV GTGMERAVAVDSGVTAVAKRGGVVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPC VSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVS RDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLLRAIFGEKA SDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLV AGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVLKIV KVYLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMA AKGIGDKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGA KEAEIKELLKLGDLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLG GKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEI RSLGINIELEDE",rpoB,RNAP subunit beta; Transcriptase subunit beta; RNA polymerase subunit beta,1342,150635,4.89,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: Not Available",Transcription,"PF04563:RNA_pol_Rpb2_1 PF04561:RNA_pol_Rpb2_2 PF04565:RNA_pol_Rpb2_3 PF00562:RNA_pol_Rpb2_6 PF04560:RNA_pol_Rpb2_7","",Cytoplasmic,,"","",None,None,Essential,"",rpoB,"",M38303,"","" 1280,DNA-directed RNA polymerase beta' chain,2009-07-22 22:37:11 UTC,2009-08-13 06:39:43 UTC,P0A674,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates,"",">DNA-directed RNA polymerase subunit beta' MLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRF KGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVD EEMRHNELSTLEAEMAVERKAVEDQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGEREMRQIRD RAQRELDRLEDIWSTFTKLAPKQLIVDENLYRELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDV IRNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINR NNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGK RVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEV IAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILML SSNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPASGDHPETGVYSSPAEAIMAADRGVLSVR AKIKVRLTQLRPPVEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDL AERYPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQRGALNHDER NEALVEIWKEATDEVGQALREHYPDDNPIITIVDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSF REGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAERAPDGTL IRDPYIETSAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGITQVKVRSVLTCATSTGVCATCYG RSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPRVQELFEARVPRGKAPIADVT GRVRLEDGERFYKITIVPDDGGEEVVYDKISKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSADPHE VLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIDRAEFEAEN RRVVAEGGEPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPA GTGINRYRNIAVQPTEEARAAAYTIPSYEDQYYSPDFGAATGAAVPLDDYGYSDYR",rpoC,RNAP subunit beta'; Transcriptase subunit beta'; RNA polymerase subunit beta',1316,146771,6.08,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed RNA polymerase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: transcription || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus",Transcription,"PF04997:RNA_pol_Rpb1_1 PF00623:RNA_pol_Rpb1_2 PF04983:RNA_pol_Rpb1_3 PF05000:RNA_pol_Rpb1_4 PF04998:RNA_pol_Rpb1_5","",Cytoplasmic,,"","",None,None,Essential,"",rpoC,"",L27989,"","" 1281,Apoptosis regulator Bcl-2,2009-07-22 22:37:12 UTC,2009-08-13 06:39:37 UTC,P10415,Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1),"",">Apoptosis regulator Bcl-2 MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTS PLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRD GVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLF DFSWLSLKTLLSLALVGACITLGAYLGHK",BCL2,"",239,26266,7.32,">>> Function: Not Available || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of cellular physiological process Process: regulation of programmed cell death Process: regulation of apoptosis || >>> Component: cell Component: membrane","","PF00452:Bcl-2 PF02180:BH4",HGNC:990,Mitochondrion outer membrane,,REACT_578-Apoptosis;,"",None,212-233,Non Essential,"",BCL2,BCL2,S72602,"","" 1282,Caspase-3,2009-07-22 22:37:13 UTC,2009-08-13 06:39:41 UTC,P42574,"Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin","",">Caspase-3 MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVD AANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKIT NFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSK DGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH",CASP3,CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Yama protein; SREBP cleavage activity 1; SCA-1; Contains: RecName: Caspase-3 subunit p17; Contains: RecName: Caspase-3 subunit p12,277,31608,6.51,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: cysteine-type endopeptidase activity Function: caspase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis || >>> Component: Not Available","",PF00656:Peptidase_C14,HGNC:1504,Cytoplasm,,REACT_578-Apoptosis;,"",None,None,Non Essential,1CP3,CASP3,CASP3,BC016926,"","" 1283,Cytochrome c,2009-07-22 22:37:13 UTC,2009-08-13 06:39:53 UTC,P99999,"Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases","",">Cytochrome c MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIWGEDTLMEYLE NPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE",CYCS,"",105,11749,10.16,">>> Function: transporter activity Function: electron transporter activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,PF00034:Cytochrom_C,HGNC:19986,Mitochondrion matrix,,REACT_578-Apoptosis;,"",None,None,Non Essential,1J3S,CYCS,CYCS,BC071761,"","" 1284,"Peptidyl-prolyl cis-trans isomerase, mitochondrial",2009-07-22 22:37:15 UTC,2009-08-13 06:39:34 UTC,P30405,PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides,"",">Peptidyl-prolyl cis-trans isomerase, mitochondrial MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLGRVVLELKADV VPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSIYGSRFPDENFTLKHVGPGVL SMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDVVKKIESFGSKSGRTSKKIVITDCGQLS",PPIF,PPIase; Rotamase; Cyclophilin F,207,22040,9.95,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein folding || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00160:Pro_isomerase,HGNC:9259,Mitochondrion matrix,,"","",None,None,Non Essential,2BIU,PPIF,PPIF,BC005020,"","" 1285,Beta-galactosidase,2009-07-22 22:37:15 UTC,2009-08-13 06:39:52 UTC,P00722,Hydrolysis of terminal non-reducing beta-D- galactose residues in beta-D-galactosides,"",">Beta-galactosidase MTMITDSLAVVLQRRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWRFAWFPAPEAV PESWLECDLPEADTVVVPSNWQMHGYDAPIYTNVTYPITVNPPFVPTENPTGCYSLTFNVDESWLQEGQT RIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFDLSAFLRAGENRLAVMVLRWSDGSYLEDQDMWRMSGIF RDVSLLHKPTTQISDFHVATRFNDDFSRAVLEAEVQMCGELRDYLRVTVSLWQGETQVASGTAPFGGEII DERGGYADRVTLRLNVENPKLWSAEIPNLYRAVVELHTADGTLIEAEACDVGFREVRIENGLLLLNGKPL LIRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHG MVPMNRLTDDPRWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGG GADTTATDIICPMYARVDEDQPFPAVPKWSIKKWLSLPGETRPLILCEYAHAMGNSLGGFAKYWQAFRQY PRLQGGFVWDWVDQSLIKYDENGNPWSAYGGDFGDTPNDRQFCMNGLVFADRTPHPALTEAKHQQQFFQF RLSGQTIEVTSEYLFRHSDNELLHWMVALDGKPLASGEVPLDVAPQGKQLIELPELPQPESAGQLWLTVR VVQPNATAWSEAGHISAWQQWRLAENLSVTLPAASHAIPHLTTSEMDFCIELGNKRWQFNRQSGFLSQMW IGDKKQLLTPLRDQFTRAPLDNDIGVSEATRIDPNAWVERWKAAGHYQAEAALLQCTADTLADAVLITTA HAWQHQGKTLFISRKTYRIDGSGQMAITVDVEVASDTPHPARIGLNCQLAQVAERVNWLGLGPQENYPDR LTAACFDRWDLPLSDMYTPYVFPSENGLRCGTRELNYGPHQWRGDFQFNISRYSQQQLMETSHRHLLHAE EGTWLNIDGFHMGIGGDDSWSPSVSAEFQLSAGRYHYQLVWCQK",lacZ,Lactase,1024,116484,5.20,">>> Function: galactosidase activity Function: beta-galactosidase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on glycosyl bonds Function: hydrolase activity, hydrolyzing O-glycosyl compounds || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: protein complex Component: unlocalized protein complex Component: beta-galactosidase complex",Carbohydrate transport and metabolism,"PF02929:Bgal_small_N PF00703:Glyco_hydro_2 PF02836:Glyco_hydro_2_C PF02837:Glyco_hydro_2_N","",Cytoplasmic,,"","",None,None,Essential,1JZ2,lacZ,"",V00295,"","" 1286,FK506-binding protein 1A,2009-07-22 22:37:16 UTC,2009-08-13 06:39:31 UTC,P62943,"May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)","",">Peptidyl-prolyl cis-trans isomerase FKBP1A MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVG QRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE",FKBP1A,PPIase FKBP1A; FK506-binding protein 1A; FKBP-1A; Rotamase; Immunophilin FKBP12; 12 kDa FKBP; FKBP-12,108,11951,8.48,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein folding || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00254:FKBP_C,"",Cytoplasm (By similarity),,"","",None,None,Essential,1J4I,FKBP1A,"",M89928,"","" 1287,Aldo-keto reductase family 1 member C3,2009-07-22 22:37:16 UTC,2009-08-13 06:39:42 UTC,P42330,"Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone","",">Aldo-keto reductase family 1 member C3 MDSKQQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIA DGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFD IVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKD IVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQN VQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY",AKR1C3,"Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; Testosterone 17-beta-dehydrogenase 5; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; Prostaglandin F synthase; PGFS; Dihydrodiol dehydrogenase type I; Dihydrodiol dehydrogenase 3; DD-3; DD3; Chlordecone reductase homolog HAKRb; HA1753",323,36845,8.06,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00248:Aldo_ket_red,HGNC:386,Cytoplasm,,"","",None,None,Non Essential,1XF0,AKR1C3,AKR1C3,BC019230,"","" 1288,Alcohol dehydrogenase E chain,2009-07-22 22:37:16 UTC,2009-08-13 06:39:35 UTC,P00327,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase E chain MSTAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEA AGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHH FLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIM GCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTAL SCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHV LPFEKINEGFDLLRSGESIRTILTF","","",375,39936,8.08,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N","",Cytoplasm,,"","",None,None,Essential,1P1R,"","",M64864,"","" 1289,Plasminogen activator inhibitor 1,2009-07-22 22:37:16 UTC,2009-08-13 06:39:56 UTC,P05121,"This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis","",">Plasminogen activator inhibitor 1 MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQ LTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLF RSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRR LFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQ LISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIE VNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP",SERPINE1,PAI-1; PAI; Endothelial plasminogen activator inhibitor,402,45061,7.22,">>> Function: enzyme regulator activity Function: enzyme inhibitor activity Function: protease inhibitor activity Function: endopeptidase inhibitor activity Function: serine-type endopeptidase inhibitor activity || >>> Process: Not Available || >>> Component: Not Available","",PF00079:Serpin,HGNC:8583,Secreted,,REACT_604-Hemostasis;,"",1-23,None,Non Essential,1C5G,SERPINE1,SERPINE1,X04744,"","" 1290,Bacillolysin,2009-07-22 22:37:16 UTC,2009-08-13 06:39:38 UTC,P43133,Extracellular zinc metalloprotease,"",">Bacillolysin MKRKMKMKLVRFGLAAGLAAQVFFLPYNALASTEHVTWNQQFQTPQFISGDLLKVNGTSPEELVYQYVEK NENKFKFHENAKDTLQLKEKKNDNLGFTFMRFQQTYKGIPVFGAVVTAHVKDGTLTALSGTLIPNLDTKG SLKSGKKLSEKQARDIAEKDLVANVTKEVPEYEQGKDTEFVVYVNGDEASLAYVVNLNFLTPEPGNWLYI IDAVDGKILNKFNQLDAAKPGDVKSITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAK YRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFW NGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPD WEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSV VGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK",nprS,Neutral protease,551,60617,6.15,">>> Function: endopeptidase activity Function: metalloendopeptidase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: metallopeptidase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis || >>> Component: extracellular region",Amino acid transport and metabolism,"PF07504:FTP PF03413:PepSY PF01447:Peptidase_M4 PF02868:Peptidase_M4_C","",Secreted,,"","",1-31,None,Essential,1KTO,nprS,"",M21663,"","" 1291,"Triosephosphate isomerase, glycosomal",2009-07-22 22:37:17 UTC,2009-08-13 06:39:27 UTC,P04789,D-glyceraldehyde 3-phosphate = glycerone phosphate,"",">Triosephosphate isomerase, glycosomal MSKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVVASTFVHLAMTKERLSHPKFVIAAQNAIAK SGAFTGEVSLPILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGFMVIACIGETLQERESGRTA VVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRILY GGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKATQ","",TIM; Triose-phosphate isomerase,250,26835,9.40,">>> Function: catalytic activity Function: isomerase activity Function: intramolecular oxidoreductase activity Function: intramolecular oxidoreductase activity, interconverting aldoses and ketoses Function: triose-phosphate isomerase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00121:TIM,"",Glycosome,,"","",None,None,Essential,1IIH,"","",X03921,"","" 1292,Cationic trypsin,2009-07-22 22:37:17 UTC,2009-08-13 06:39:45 UTC,P00760,"Preferential cleavage:Arg-|-Xaa, Lys-|-Xaa","",">Cationic trypsin MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQ VRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCL ISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKL QGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN","",Beta-trypsin; Contains: RecName: Alpha-trypsin chain 1; Contains: RecName: Alpha-trypsin chain 2,246,25785,8.14,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis || >>> Component: Not Available","",PF00089:Trypsin,"","Secreted, extracellular space",,"","",1-17,None,Essential,1UTQ,"","",D38507,"","" 1293,Regulatory protein E2,2009-07-22 22:37:17 UTC,2009-08-13 06:39:50 UTC,P04015,E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication,"",">Regulatory protein E2 MEAIAKRLDACQDQLLELYEENSIDIHKHIMHWKCIRLESVLLHKAKQMGLSHIGLQVVPPLTVSETKGH NAIEMQMHLESLAKTQYGVEPWTLQDTSYEMWLTPPKRCFKKQGNTVEVKFDGCEDNVMEYVVWTHIYLQ DNDSWVKVTSSVDAKGIYYTCGQFKTYYVNFNKEAQKYGSTNHWEVCYGSTVICSPASVSSTVREVSIAE PTTYTPAQTTAPTVSACTTEDGVSAPPRKRARGPSTNNTLCVANIRSVDSTINNIVTDNYNKHQRRNNCH SAATPIVQLQGDSNCLKCFRYRLNDKYKHLFELASSTWHWASPEAPHKNAIVTLTYSSEEQRQQFLNSVK IPPTIRHKVGFMSLHLL",E2,"",367,41710,7.89,">>> Function: nucleic acid binding Function: DNA binding Function: transcription factor activity Function: binding Function: nucleotide binding || >>> Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of DNA metabolism Process: regulation of DNA replication || >>> Component: extracellular region Component: extraorganismal space Component: host Component: host cell nucleus","","PF00511:PPV_E2_C PF00508:PPV_E2_N","",Nucleus,,"","",None,None,Non Essential,1R6K,E2,"",M14119,"","" 1294,Oxygen-insensitive NAD(P)H nitroreductase,2009-07-22 22:37:17 UTC,2009-08-13 06:39:31 UTC,P38489,"Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5- (aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species","",">Oxygen-insensitive NAD(P)H nitroreductase MDIISVALKRHSTKAFDASKKLTPEQAEQIKTLLQYSPSSTNSQPWHFIVASTEEGKARVAKSAAGNYVF NERKMLDASHVVVFCAKTAMDDVWLKLVVDQEDADGRFATPEAKAANDKGRKFFADMHRKDLHDDAEWMA KQVYLNVGNFLLGVAALGLDAVPIEGFDAAILDAEFGLKEKGYTSLVVVPVGHHSVEDFNATLPKSRLPQ NITLTEV",nfnB,FMN-dependent nitroreductase; Dihydropteridine reductase,217,23905,6.16,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,PF00881:Nitroreductase,"","",,"","",None,None,Essential,1YLU,nfnB,"",AP009048,"","" 1295,Gag-Pol polyprotein,2009-07-22 22:37:17 UTC,2009-08-13 06:39:57 UTC,P03366,"Integrase catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein, Vpr and integrase. This complex is called the pre- integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step, the PIC enters cell nucleus. This process is mediated through integrase and Vpr proteins, and allow the virus to infect a non dividing cell. This ability to enter the nucleus is specific of lentiviruses, other retroviruses cannot and rely on cell division to access cell chromosomes. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The 5'-ends are produced by integrase-catalyzed staggered cuts, 5 bp apart. A Y-shaped, gapped, recombination intermediate results, with the 5'-ends of the viral DNA strands and the 3' ends of target DNA strands remaining unjoined, flanking a gap of 5 bp. The last step is viral DNA integration into host chromosome. This involves host DNA repair synthesis in which the 5 bp gaps between the unjoined strands are filled in and then ligated. Since this process occurs at both cuts flanking the HIV genome, a 5 bp duplication of host DNA is produced at the ends of HIV-1 integration. Alternatively, Integrase may catalyze the excision of viral DNA just after strand transfer, this is termed disintegration (By similarity)","",">Gag-Pol polyprotein MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQT GSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSSQVSQNYPIVQNIQG QMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAA EWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPT SILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTAC QGVGGPGHKARVLAEAMSQVTNTATIMMQRGNFRNQRKMVKCFNCGKEGHTARNCRAPRKKGCWKCGKEG HQMKDCTERQANFLREDLAFLQGKAREFSSEQTRANSPTISSEQTRANSPTRRELQVWGRDNNSPSEAGA DRQGTVSFNFPQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKI KALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLK KKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPF KKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILK EPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIV IWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETK LGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQI IEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKILFLDGIDKAQDEHEKYHSNWRAMASDFNLPPV VAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFL LKLAGRWPVKTIHTDNGSNFTSATVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEH LKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNPLWKGPAKL LWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED",gag-pol,Pr160Gag-Pol; Contains: RecName: Matrix protein p17; MA; Contains: RecName: Capsid protein p24; CA; Contains: RecName: Spacer peptide p2; Contains: RecName: Nucleocapsid protein p7; NC; Contains: RecName: Transframe peptide; TF; Contains: RecName: p6-pol; p6*; Contains: RecName: Protease; Retropepsin; PR; Contains: RecName: Reverse transcriptase/ribonuclease H; p66 RT; Contains: RecName: p51 RT; Contains: RecName: p15; Contains: RecName: Integrase; IN,1447,163290,9.11,">>> Function: hydrolase activity, acting on ester bonds Function: nuclease activity Function: endonuclease activity Function: endoribonuclease activity Function: endoribonuclease activity, producing 5'-phosphomonoesters Function: ribonuclease H activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: aspartic-type endopeptidase activity Function: structural molecule activity Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: DNA binding Function: integrase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: RNA-directed DNA polymerase activity Function: binding Function: nucleic acid binding Function: RNA binding || >>> Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis Process: DNA integration Process: DNA recombination Process: viral life cycle Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA replication Process: RNA-dependent DNA replication || >>> Component: Not Available","","PF00540:Gag_p17 PF00607:Gag_p24 PF00552:Integrase PF02022:Integrase_Zn PF00075:RnaseH PF00665:rve PF00077:RVP PF00078:RVT_1 PF06815:RVT_connect PF06817:RVT_thumb PF00098:zf-CCHC","",Integrase:Virion (Potential). Nucleus (Potential). Cytoplasm (Potential),,"","",None,None,Non Essential,1TV6,gag-pol,"",K02083,"","" 1296,Thermonuclease,2009-07-22 22:37:17 UTC,2009-08-13 06:39:51 UTC,P00644,Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond,"",">Thermonuclease MLVMTEYLLSAGICMAIVSILLIGMAISNVSKGQYAKRFFFFATSCLVLTLVVVSSLSSSANASQTDNGV NRSGSEDPTVYSATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEA SAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKS EAQAKKEKLNIWSEDNADSGQ",nuc,TNase; Micrococcal nuclease; Staphylococcal nuclease; Contains: RecName: Nuclease B; Contains: RecName: Nuclease A,231,25472,9.75,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: nuclease activity Function: binding Function: nucleic acid binding || >>> Process: Not Available || >>> Component: Not Available","Replication, recombination and repair",PF00565:SNase,"",Nuclease B:Membrane,,"","",1-26,None,Essential,1EYD,nuc,"",V01281,"","" 1297,Dimethyl sulfoxide/trimethylamine N-oxide reductase,2009-07-22 22:37:18 UTC,2009-08-13 06:39:34 UTC,Q52675,Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds,"",">Dimethyl sulfoxide/trimethylamine N-oxide reductase MTKFSGNELRAELYRRAFLSYSVAPGALGMFGRSLLAKGARAEALANGTVMSGSHWGVFTATVENGRATA FTPWEKDPHPTPMLEGVLDSIYSPTRIKYPMVRREFLEKGVNADRSTRGNGDFVRVSWDQALDLVAAEVK RVEETYGPQGVFGGSYGWKSPGRLHNCTTLLRRMLTLAGGYVNGAGDYSTGAAQVIMPHVVGTLEVYEQQ TAWPVLAENTEVMVFWAADPIKTSQIGWVIPEHGAYPGLEALKAKGTKVIVIDPVRTKTVEFFGADHVTP KPQTDVAIMLGMAHTLVAEDLYDKDFIANYTSGFDKFLPYLMGETDSTPKTAEWASDISGVPAETIKELA RLFISKRTMLAAGWSMQRMHHGEQAHWMLVTLASMLGQIGLPGGGFGLSYHYSGGGTPSTSGPALSGITD GGAATKGPEWLAASGASVIPVARVVDMLENPGAEFDFNGTRSKFPDVKMAYWVGGNPFVHHQDRNRMVKA WEKLETFIVHDFQWTPTARHADIVLPATTSYERNDIETIGDYSNTGILAMKKIVEPLYEARSDYDIFAAV AERLGKGKEFTEGKDEMGWIKSFYDDAAKQGKAGGVEMPAFDAFWAEGIVEFPVTDGADFVRYASFREDP LLNPLGTPTGLIEIYSKNIEKMGYDDCPAHPTWMEPLERLDGPGAKYPLHIAASHPFNRLHSQLNGTVLR EGYAVQGHEPCLMHPDDAAARGIADGDVVRVHNDRGQILTGVKVTDAVMKGVIQIYEGGWYDPSDVTEPG TLDKYGDVNVLSADIGTSKLAQGNCGQTVLAEVEKYTGPAVTLTGFVAPKAAE",dorA,DMSO reductase; DMSOR,823,89562,5.35,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: molybdenum ion binding Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,"PF00384:Molybdopterin PF01568:Molydop_binding","",Periplasm,,"","",1-42,None,Essential,1E18,dorA,"",U49506,"","" 1298,Triosephosphate isomerase,2009-07-22 22:37:18 UTC,2009-08-13 06:39:38 UTC,P00939,D-glyceraldehyde 3-phosphate = glycerone phosphate,"",">Triosephosphate isomerase APSRKFFVGGNWKMNGRKKNLGELITTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVT NGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALSEGLGVIACIGEKLDEREAGITE KVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGG SVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ",TPI1,TIM; Triose-phosphate isomerase,248,26626,7.41,">>> Function: catalytic activity Function: isomerase activity Function: intramolecular oxidoreductase activity Function: intramolecular oxidoreductase activity, interconverting aldoses and ketoses Function: triose-phosphate isomerase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00121:TIM,"","",,"","",None,None,Essential,1R2T,TPI1,"",V00902,"","" 1299,Polynucleotide kinase,2009-07-22 22:37:18 UTC,2009-08-13 06:39:56 UTC,P06855,"Acts as a 5'-hydroxyl kinase, a 3'-phosphatase and a 2',3'-cyclic phosphodiesterase. Catalyzes the transfer of the terminal phosphate of ATP to the 5'-hydroxyl termini of ribo- and deoxyribonucleotides. In the presence of ADP the enzyme also catalyzes an exchange reaction. In the exchange reaction, an excess ADP causes the enzyme to transfer the 5' terminal phosphate from phosphorylated DNA to ADP. These activities modify the ends of nicked tRNA generated by a bacterial response to infection and facilitate repair by T4 RNA ligase","",">Polynucleotide kinase MKKIILTIGCPGSGKSTWAREFIAKNPGFYNINRDDYRQSIMAHEERDEYKYTKKKEGIVTGMQFDTAKS ILYGGDSVKGVIISDTNLNPERRLAWETFAKEYGWKVEHKVFDVPWTELVKRNSKRGTKAVPIDVLRSMY KSMREYLGLPVYNGTPGKPKAVIFDVDGTLAKMNGRGPYDLEKCDTDVINPMVVELSKMYALMGYQIVVV SGRESGTKEDPTKYYRMTRKWVEDIAGVPLVMQCQREQGDTRKDDVVKEEIFWKHIAPHFDVKLAIDDRT QVVEMWRRIGVECWQVASGDF",pseT,PNK; Polynucleotide 5'-hydroxyl-kinase,301,34620,8.96,"","","","","",,"","",None,None,Essential,1RRC,pseT,"",AF158101,"","" 1300,FK506-binding protein 4,2009-07-22 22:37:18 UTC,2009-08-13 06:39:50 UTC,Q02790,Component of unactivated mammalian steroid receptor complexes that sediment at 8-10 S. May have a rotamase activity. May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors,"",">FK506-binding protein 4 MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSS LDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGE DLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQR MEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVY FKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDS NNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAE EENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA",FKBP4,Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase; HSP-binding immunophilin; HBI; FKBP52 protein; 52 kDa FK506-binding protein; FKBP59; p59 protein,459,51805,5.11,">>> Function: binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein folding || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones","PF00254:FKBP_C PF00515:TPR_1",HGNC:3720,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1QZ2,FKBP4,FKBP4,BC007924,"","" 1301,Thymidylate synthase,2009-07-22 22:37:18 UTC,2009-08-13 06:39:28 UTC,P12461,"5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP","",">Thymidylate synthase MTVSPNTAEQAYLDLCKRIIDEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKVFSKGIIHELL WFVAGSTDAKILSEKGVKIWEGNGSREFLDKLGLTHRREGDLGPVYGFQWRHFGAEYKDCDSDYTGQGFD QLQDVIKKLKTNPYDRRIIMSAWNPPDFAKMALPPCHVFCQFYVNFPTSSPDPNNPKQAKTAKPKLSCLL YQRSCDMGLGVPFNIASYALLTKMIAHVVDMDCGEFIHTLGDAHVYLDHIDALKEQFERIPKQFPKLVIK EERKNEIKSIDDFKFEDFEIVGYEPYPPIKMKMSV",TMP1,TSase; TS,315,35997,6.99,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring one-carbon groups Function: methyltransferase activity Function: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity Function: thymidylate synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: pyrimidine nucleotide metabolism Process: pyrimidine nucleotide biosynthesis Process: pyrimidine nucleoside monophosphate biosynthesis Process: pyrimidine deoxyribonucleoside monophosphate biosynthesis Process: dTMP biosynthesis || >>> Component: Not Available",Nucleotide transport and metabolism,PF00303:Thymidylat_synt,"","",,"","",None,None,Essential,"",TMP1,"",J04230,"","" 1302,Cytochrome P450 51,2009-07-22 22:37:20 UTC,2009-08-13 06:39:27 UTC,P50859,"Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity)","",">Cytochrome P450 51 MSTENTSLVVELLEYVKLGLSYFQALPLAQRVSIMVALPFVYTITWQLLYSLRKDRPPLVFYWIPWVGSA IPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNAKLADVSAEAAYSHLTTPVFGKGVI YDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTAS RSLLGKEMRDKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQ NRDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLN NDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEF FPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFI RTMKWRYPTEGETVPPSDFTSMVTLPTAPAKIYWEKRHPEQKY",ERG11,CYPLI; P450-LIA1; Sterol 14-alpha-demethylase; Lanosterol 14-alpha demethylase; P450-14DM,533,61306,7.07,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,"",Membrane (Potential). Membrane,,"","",None,None,Essential,"",ERG11,"",S75389,"","" 1303,Beta-2 adrenergic receptor,2009-07-22 22:37:23 UTC,2009-08-13 06:39:45 UTC,P07550,Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine,"",">Beta-2 adrenergic receptor MGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNY FITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFK YQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYV PLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMG TFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAY GNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL",ADRB2,Beta-2 adrenoreceptor; Beta-2 adrenoceptor,413,46557,7.44,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: adrenoceptor activity Function: beta-adrenergic receptor activity Function: beta2-adrenergic receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:286,Cell membrane,,"","",None,"35-58 72-95 107-129 151-174 197-220 275-298 306-329",Non Essential,"",ADRB2,ADRB2,DQ094845,"","" 1304,Sphingomyelin phosphodiesterase,2009-07-22 22:37:24 UTC,2009-08-13 06:39:31 UTC,P17405,"Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol","",">Sphingomyelin phosphodiesterase MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALSDSRVLWAPAEAHPLSPQGHPAR LHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFED DMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWD HDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIP AHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWE PWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKV HIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIG LNPGYRVYQIDGNYSRSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRM RGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC",SMPD1,Acid sphingomyelinase; aSMase,629,69852,7.42,">>> Function: hydrolase activity, acting on ester bonds Function: phosphoric ester hydrolase activity Function: phosphoric diester hydrolase activity Function: sphingomyelin phosphodiesterase activity Function: catalytic activity Function: hydrolase activity || >>> Process: physiological process Process: metabolism Process: primary metabolism Process: lipid metabolism Process: cellular lipid metabolism Process: membrane lipid metabolism Process: phospholipid metabolism Process: sphingomyelin metabolism Process: sphingomyelin catabolism || >>> Component: Not Available","",PF00149:Metallophos,HGNC:11120,Lysosome,,"","",1-46,None,Non Essential,"",SMPD1,SMPD1,X59960,"","" 1305,"Potassium large conductance calcium-activated channel, subfamily M, alpha member 1",2009-07-22 22:37:25 UTC,2009-07-22 22:37:25 UTC,Q5SQR9,,,,,,,,,,,,,,,,,,,,,,,,, 1306,Rhodopsin,2009-07-22 22:37:26 UTC,2009-08-13 06:39:47 UTC,P08100,Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal,"",">Rhodopsin MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRT PLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVC KPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVV HFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQG SNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA",RHO,Opsin-2,348,38893,6.64,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: response to stimulus Process: response to abiotic stimulus Process: response to radiation Process: response to light stimulus Process: detection of light stimulus Process: phototransduction Process: physiological process Process: organismal physiological process Process: neurophysiological process Process: sensory perception Process: sensory perception of light stimulus Process: visual perception Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:10012,Membrane,,"","",None,"37-61 74-98 114-133 153-176 203-230 253-276 285-309",Non Essential,1LN6,RHO,RHO,S81166,"","" 1307,Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit,2009-07-22 22:37:27 UTC,2009-08-13 06:39:56 UTC,P59768,"Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity)","",">Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAI L",GNG2,G gamma-I,71,7850,8.22,">>> Function: signal transducer activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: extrinsic to membrane Component: extrinsic to plasma membrane Component: heterotrimeric G-protein complex","",PF00631:G-gamma,HGNC:4404,Cell membrane,,"","",None,None,Non Essential,1GP2,GNG2,GNG2,BC060856,"","" 1308,Neuropeptide S receptor,2009-07-22 22:37:27 UTC,2009-08-13 06:39:47 UTC,Q6W5P4,"May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases","",">Neuropeptide S receptor MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVV LFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLV SLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPY MTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIII LAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSR MTFRERTERHEMQILSKPEFI",NPSR1,G-protein coupled receptor 154; G-protein coupled receptor for asthma susceptibility; G-protein coupled receptor PGR14,371,42687,8.44,">>> Function: peptide receptor activity, G-protein coupled Function: vasopressin-like receptor activity Function: vasopressin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:23631,Isoform 9:Cytoplasm,,"","",None,"53-73 83-103 124-144 165-185 213-233 276-296 313-333",Non Essential,"",NPSR1,NPSR1,DQ272236,"","" 1309,Prostacyclin receptor,2009-07-22 22:37:27 UTC,2009-08-13 06:39:49 UTC,P43119,Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase,"",">Prostacyclin receptor MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPA VFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLAL PAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSL CRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRF YAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLS AWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC",PTGIR,Prostanoid IP receptor; PGI receptor; Prostaglandin I2 receptor,386,40956,8.53,">>> Function: icosanoid receptor activity Function: prostanoid receptor activity Function: thromboxane receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:9602,Cell membrane,,"","",None,"17-38 52-76 95-115 135-158 182-208 236-260 275-295",Non Essential,"",PTGIR,PTGIR,BC075814,"","" 1310,CYP2B protein,2009-07-22 22:37:29 UTC,2009-08-13 06:40:00 UTC,Q14097,"","",">CYP2B7P1 protein MELSVLLFLALLTGLLLLLVQRHPNSHGTLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHL GPRPVVMLCGVEAIREALVDNAEAFSGRGKIVIMDPVYQGYGMLFANGNRWKVLRRFSVTTMRDFGMGKR SVEERIQDEAQCLIEELRKSKGALVDPTFLFHSITANIICSIIFGKRFHYQDQEFLKTLNLFCQSFLLIS SISSQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNPH SEFSHQNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYKEIEQVVGPHRPPALDDRAKMPYTE AVIREIQRFADLLPMGVPHIVTQHTSF",CYP2B,SubName: Cytochrome P450 2B7 short isoform; SubName: CYP2B protein,377,43149,9.03,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2616,"",,"","",None,None,Non Essential,"",CYP2B,CYP2B,DQ198367,"","" 1311,Arachidonate 15-lipoxygenase,2009-07-22 22:37:30 UTC,2009-08-13 06:39:51 UTC,P16050,Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid,"",">Arachidonate 15-lipoxygenase MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKRHL LKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYR WGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCG QSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSL LDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSS DFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVSLHYKTDVAVK DDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQHASVHLGQLDWYSWVPNAPCT MRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQPVMVAVGQHEEEYFSGPEPKAVLKKFREEL AALDKEIEIRNAKLDMPYEYLRPSVVENSVAI",ALOX15,15-LOX; Arachidonate omega-6 lipoxygenase,662,74805,6.56,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Function: lipoxygenase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding || >>> Process: organic acid metabolism Process: carboxylic acid metabolism Process: fatty acid metabolism Process: icosanoid metabolism Process: leukotriene metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","","PF00305:Lipoxygenase PF01477:PLAT",HGNC:433,Cytoplasm,,"","",None,None,Non Essential,"",ALOX15,ALOX15,U63384,"","" 1312,cAMP response element-binding protein,2009-07-22 22:37:33 UTC,2009-08-13 06:39:43 UTC,P16220,"This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transciption activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity","",">cAMP response element-binding protein MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVI QAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILND LSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMT NAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAE EAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD",CREB1,CREB,341,36688,5.24,">>> Function: transcription factor activity Function: protein binding Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00170:bZIP_1 PF02173:pKID",HGNC:2345,Nucleus,,"","",None,None,Non Essential,"",CREB1,CREB1,S53724,"","" 1313,Somatostatin,2009-07-22 22:37:33 UTC,2009-08-13 06:39:32 UTC,P61278,Somatostatin inhibits the release of somatotropin,"",">Somatostatin MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPNQTENDALEP EDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC",SST,Growth hormone release-inhibiting factor; Contains: RecName: Somatostatin-28; Contains: RecName: Somatostatin-14,116,12736,5.18,">>> Function: signal transducer activity Function: receptor binding Function: hormone activity || >>> Process: Not Available || >>> Component: extracellular region","",PF03002:Somatostatin,HGNC:11329,Secreted,,"","",1-24,None,Non Essential,"",SST,SST,BC032625,"","" 1314,Synaptic vesicle glycoprotein 2A,2009-07-22 22:37:34 UTC,2009-08-13 06:39:35 UTC,Q7L0J3,"Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity)","",">Synaptic vesicle glycoprotein 2A MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPSDGYYRGEG TQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQ RRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLI VYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYF SEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGA LTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRW GVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGE RVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTD LFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAG SSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLG ISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ",SV2A,"",742,82696,5.26,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF07690:MFS_1,HGNC:20566,"Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane",,"","",None,"170-190 206-226 234-254 263-283 295-315 335-355 448-468 599-619 627-647 652-672 686-708 713-731",Non Essential,"",SV2A,SV2A,BC045111,"","" 1315,ATP-binding cassette sub-family G member 2,2009-07-22 22:37:34 UTC,2009-08-13 06:39:36 UTC,Q9UNQ0,"Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123","",">ATP-binding cassette sub-family G member 2 MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGI MKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENL QFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLD EPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESA GYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELH QLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFT CIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTT IASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNH VALACMIVIFLTIAYLKLLFLKKYS",ABCG2,Placenta-specific ATP-binding cassette transporter; Breast cancer resistance protein; Mitoxantrone resistance-associated protein; CDw338; CD338 antigen,655,72315,8.90,">>> Function: ATPase activity Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: binding Function: nucleotide binding || >>> Process: Not Available || >>> Component: Not Available",Defense mechanisms,"PF01061:ABC2_membrane PF00005:ABC_tran",HGNC:74,Cell membrane,,"","",None,"396-416 429-449 478-498 507-527 536-556 631-651",Non Essential,"",ABCG2,ABCG2,AK002040,"","" 1316,Thromboxane A2 synthase,2009-07-22 22:37:35 UTC,2009-07-22 22:37:35 UTC,O14987,,,,,,,,,,,,,,,,,,,,,,,,, 1317,Thromboxane A2 receptor,2009-07-22 22:37:35 UTC,2009-08-13 06:39:47 UTC,P21731,"Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction","",">Thromboxane A2 receptor MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGL VLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSR PAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGL SFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAG QLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRRVSLCGPAWSTVARSRLTATSA SRVQAILVPQPPEQLGLQA",TBXA2R,TXA2-R; Prostanoid TP receptor,369,40093,10.31,">>> Function: icosanoid receptor activity Function: prostanoid receptor activity Function: thromboxane receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:11608,Cell membrane,,"","",None,"30-52 67-87 107-128 150-172 194-219 247-270 290-311",Non Essential,"",TBXA2R,TBXA2R,BC074750,"","" 1318,Substance-P receptor,2009-07-22 22:37:36 UTC,2009-08-13 06:39:36 UTC,P25103,This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is:substance P > substance K > neuromedin-K,"",">Substance-P receptor MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYF LVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQP RLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLL VIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLK KFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYK VSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS",TACR1,SPR; NK-1 receptor; NK-1R; Tachykinin receptor 1,407,46251,7.22,">>> Function: peptide receptor activity, G-protein coupled Function: neuropeptide receptor activity Function: tachykinin receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: plasma membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:11526,Cell membrane,,"","",None,"32-54 65-86 107-128 149-169 195-219 249-270 284-308",Non Essential,"",TACR1,TACR1,BC074912,"","" 1319,Phenylalanine-4-hydroxylase,2009-07-22 22:37:37 UTC,2009-08-13 06:39:59 UTC,P00439,L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin,"",">Phenylalanine-4-hydroxylase MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPS RLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGA ELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIF PLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPE PDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSS FGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQR IEVLDNTQQLKILADSINSEIGILCSALQKIK",PAH,PAH; Phe-4-monooxygenase,452,51863,6.57,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Function: phenylalanine 4-monooxygenase activity Function: amine binding Function: amino acid binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: L-phenylalanine metabolism Process: L-phenylalanine catabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: aromatic amino acid family metabolism || >>> Component: Not Available",Amino acid transport and metabolism,"PF01842:ACT PF00351:Biopterin_H",HGNC:8582,"",,"","",None,None,Non Essential,2PHM,PAH,PAH,BC026251,"","" 1320,Phenylethylamine oxidase,2009-07-22 22:37:38 UTC,2009-08-13 06:39:39 UTC,P46881,RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2),"",">Phenylethylamine oxidase MTPSTIQTASPFRLASAGEISEVQGILRTAGLLGPEKRIAYLGVLDPARGAGSEAEDRRFRVFIHDVSGA RPQEVTVSVTNGTVISAVELDTAATGELPVLEEEFEVVEQLLATDERWLKALAARNLDVSKVRVAPLSAG VFEYAEERGRRILRGLAFVQDFPEDSAWAHPVDGLVAYVDVVSKEVTRVIDTGVFPVPAEHGNYTDPELT GPLRTTQKPISITQPEGPSFTVTGGNHIEWEKWSLDVGFDVREGVVLHNIAFRDGDRLRPIINRASIAEM VVPYGDPSPIRSWQNYFDTGEYLVGQYANSLELGCDCLGDITYLSPVISDAFGNPREIRNGICMHEEDWG ILAKHSDLWSGINYTRRNRRMVISFFTTIGNYDYGFYWYLYLDGTIEFEAKATGVVFTSAFPEGGSDNIS QLAPGLGAPFHQHIFSARLDMAIDGFTNRVEEEDVVRQTMGPGNERGNAFSRKRTVLTRESEAVREADAR TGRTWIISNPESKNRLNEPVGYKLHAHNQPTLLADPGSSIARRAAFATKDLWVTRYADDERYPTGDFVNQ HSGGAGLPSYIAQDRDIDGQDIVVWHTFGLTHFPRVEDWPIMPVDTVGFKLRPEGFFDRSPVLDVPANPS QSGSHCHG","",Primary amine oxidase,638,70647,4.81,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: copper ion binding || >>> Process: Not Available || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism","PF01179:Cu_amine_oxid PF02727:Cu_amine_oxidN2 PF02728:Cu_amine_oxidN3","","",,"","",None,None,Essential,1IVU,"","","","","" 1321,Glutathione S-transferase pi,2009-07-22 22:37:41 UTC,2009-07-22 22:37:41 UTC,Q5TZY3,,,,,,,,,,,,,,,,,,,,,,,,, 1322,Methyl-CpG-binding domain protein 2,2009-07-22 22:37:42 UTC,2009-08-13 06:39:59 UTC,Q9UBB5,Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemi-methylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Isoform 1 may enhance the activation of some unmethylated cAMP-responsive promoters. Reports about DNA demethylase activity of isoform 2 are contradictory,"",">Methyl-CpG-binding domain protein 2 MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRG GGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRG PRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRT GKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQ LFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAV WLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA",MBD2,Methyl-CpG-binding protein MBD2; Demethylase; DMTase,411,43255,10.76,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: Not Available || >>> Component: Not Available",Carbohydrate transport and metabolism,PF01429:MBD,HGNC:6917,Nucleus,,"","",None,None,Non Essential,"",MBD2,MBD2,BC032638,"","" 1323,UDP-glucuronosyltransferase 2B28,2009-07-22 22:37:44 UTC,2009-08-13 06:39:41 UTC,Q9BY64,"UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active","",">UDP-glucuronosyltransferase 2B28 MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAF TLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKL QESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMER VKNMIYVLYFDFWFQMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGL HCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLN TRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTM SSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHS LDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD",UGT2B28,UDPGT,529,60907,8.80,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring hexosyl groups || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF00201:UDPGT,HGNC:13479,Microsome membrane,,"","",1-24,495-517,Non Essential,"",UGT2B28,UGT2B28,AF177274,"","" 1324,Glycine receptor subunit alpha-3,2009-07-23 18:27:16 UTC,2009-08-13 06:39:34 UTC,O75311,The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing),"",">Glycine receptor subunit alpha-3 MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPV NVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGAN FHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQ VAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMD AAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRF RRKRKNKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKV FIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD",GLRA3,"",464,53801,8.51,">>> Function: neurotransmitter receptor activity Function: anion channel activity Function: chloride channel activity Function: glycine-gated chloride channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4328,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-33,"253-279 286-303 315-341 434-451",Non Essential,"",GLRA3,GLRA3,BC036086,"","" 1325,Glycine receptor subunit alpha-4,2009-07-23 18:27:16 UTC,2009-08-13 06:39:40 UTC,Q5JXX5,The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing),"",">Glycine receptor subunit alpha-4 MTTLVPATLSFLLLWTLPGPLLSRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPP VNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGA NFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESVGYTMKDLVFEWLEDAPA VQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWIN MDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQHKEFI RLRRRQRRQRLEEDIIQESRFYFRGYGLGHCLQARDGGPMEGSGIYSPQPPAPLLREGETTRKLYVDAKR IDTISRAVFPFTFLIFNIFYWVVYKVLWSEDIHQAL",GLRA4,"",456,52369,8.51,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:31715,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-28,"259-279 322-342 428-448",Non Essential,"",GLRA4,GLRA4,AL049610,"","" 1326,Glycine receptor subunit beta,2009-07-23 18:27:17 UTC,2009-08-13 06:39:50 UTC,P48167,The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing),"",">Glycine receptor subunit beta MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPR IRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWK PDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDD LRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLI VVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVV QVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDF SIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNV IYWSIYL",GLRB,Glycine receptor 58 kDa subunit,497,56123,9.11,">>> Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: anion channel activity Function: chloride channel activity Function: glycine-gated chloride channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: chloride transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4329,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-22,"266-290 299-316 331-354 479-496",Non Essential,1T3E,GLRB,GLRB,BC032635,"","" 1327,Alpha-mannosidase 2,2009-07-23 18:27:46 UTC,2009-08-13 06:39:44 UTC,Q16706,Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway,"",">Alpha-mannosidase 2 MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIIS NIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISF DNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRK FIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGV KPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMP FYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLL APLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLS GDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEAR RNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQK SQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISET AYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFD QTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTC FFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKL PLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLF RILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVN LRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSP PGTQNISEINLSPMEISTFRIQLR",MAN2A1,"Alpha-mannosidase II; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase; MAN II; Golgi alpha-mannosidase II; Mannosidase alpha class 2A member 1",1144,131142,7.61,">>> Function: alpha-mannosidase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on glycosyl bonds Function: hydrolase activity, hydrolyzing O-glycosyl compounds Function: mannosidase activity || >>> Process: macromolecule metabolism Process: carbohydrate metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: alcohol metabolism Process: monosaccharide metabolism Process: hexose metabolism Process: mannose metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,"PF09261:Alpha-mann_mid PF01074:Glyco_hydro_38 PF07748:Glyco_hydro_38C",HGNC:6824,Golgi apparatus membrane,,"","",None,6-26,Non Essential,"",MAN2A1,MAN2A1,D63998,"","" 1328,Alpha-mannosidase 2x,2009-07-23 18:27:46 UTC,2009-07-23 18:27:46 UTC, P49641,,,,,,,,,,,,,,,,,,,,,,,,, 1330,L-xylulose reductase,2009-08-10 19:19:41 UTC,2009-08-13 06:39:36 UTC,Q7Z4W1,"Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.","",">L-xylulose reductase MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERA LGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQ RAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFA EVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWAC",DCXR,XR; Dicarbonyl/L-xylulose reductase; Kidney dicarbonyl reductase; kiDCR; Carbonyl reductase II; Sperm surface protein P34H,244,25913,8.23,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Lipid transport and metabolism,PF00106:adh_short,HGNC:18985,Membrane,,"","",None,None,Non Essential,1PR9,DCXR,DCXR,BC003018,"","" 1331,"Gamma-aminobutyric acid type B receptor, subunit 2",2009-08-11 22:07:10 UTC,2009-08-13 06:39:54 UTC,O75899,"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception","",">Gamma-aminobutyric acid type B receptor subunit 2 MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAK GSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTS IIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSE VRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWI IPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVG PSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNG ERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTI LGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWIL TVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSM EPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVG IMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKED SKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNL GNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGV DASCVSPCVSPTASPRHRHVPPSFRVMVSGL",GABBR2,GABA-B receptor 2; GABA-B-R2; GABABR2; Gb2; G-protein coupled receptor 51; HG20,941,105823,8.83,">>> Function: GABA-B receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: metabotropic glutamate, GABA-B-like receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF00003:7tm_3 PF01094:ANF_receptor",HGNC:4507,Cell membrane,,"","",1-41,"484-504 523-543 552-572 598-618 655-675 692-712 721-741",Non Essential,"",GABBR2,GABBR2,AL591502,"","" 1332,Dihydropteroate synthase 2,2009-08-11 22:07:22 UTC,2009-08-13 06:39:32 UTC,P0C0X2,DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide (By similarity),"",">Dihydropteroate synthase 2 MQSMLCGRPVAADRQLIMAIVNRTPDSFYDRGATFSDEAARAAAHRAVAEGADVIDVGGVKAGPGQGVDV DTEIARLVPFIEWLRSAYTDLLISVDTWRAEVARLACTAGADLINDSWGGADPAMHEVAAELGAGLVCSH TGGALPRTRPFRVSYGTTTRGVVDDVIRQVTAAAERAVAAGVTRDSVLVDPTHDFGKNTFHGLLLLRHVD ELVKTGWPVLMSLSNKDFVGETLGVGLTERLEGTLAATALAAAAGVRMFRVHEVVATRRVLEMVASIQGT RPPTRTVRGLA",folP2,DHPS 2; Dihydropteroate pyrophosphorylase 2,291,30852,6.40,">>> Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: dihydropteroate synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: aromatic compound metabolism Process: folic acid and derivative metabolism Process: folic acid and derivative biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00809:Pterin_bind,"","",,"","",None,None,Essential,"",folP2,"",AL583920,"","" 1333,Dihydropteroate synthase 1,2009-08-11 22:07:22 UTC,2009-08-13 06:40:00 UTC,P0C0X1,DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide (By similarity),"",">Dihydropteroate synthase 1 MSLAPVQVIGVLNVTDNSFSDGGRYLDPDDAVQHGLAMVAEGAAIVDVGGESTRPGAIRTDPRVELSRIV PVVKELAAQGITVSIDTTRADVARAALQSGARIVNDVSGGRADPAMAPLVAEAGVAWVLMHWRLMSAERP YEAPNYRDVVAEVRADLLAGVDQAVAAGVDPGSLVIDPGLGFAKTGQHNWALLNALPELVATGVPILLGA SRKRFLGRLLAGADGAVRPPDGRETATAVISALAALHGAWGVRVHDVRASVDALKVVGAWLHAGPQIEKV RCDG",folP1,DHPS 1; Dihydropteroate pyrophosphorylase 1,284,29448,5.63,">>> Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: dihydropteroate synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: aromatic compound metabolism Process: folic acid and derivative metabolism Process: folic acid and derivative biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00809:Pterin_bind,"","",,"","",None,None,Essential,"",folP1,"",AL583917,"","" 1334,Farnesyl pyrophosphate synthetase,2009-08-11 22:07:25 UTC,2009-08-13 06:39:35 UTC,P14324,"Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate","",">Farnesyl pyrophosphate synthetase MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGD QNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEP RKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLK LYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAM YMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQ ILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK",FDPS,FPP synthetase; FPS; Farnesyl diphosphate synthetase; Dimethylallyltranstransferase; Geranyltranstransferase,419,48276,6.02,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: primary metabolism Process: lipid metabolism Process: cellular lipid metabolism Process: isoprenoid metabolism Process: isoprenoid biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00348:polyprenyl_synt,HGNC:3631,Cytoplasm,,"","",None,None,Non Essential,1YV5,FDPS,FDPS,M29863,"","" 1335,Solute carrier organic anion transporter family member 1B1,2009-08-11 22:07:40 UTC,2009-08-13 06:39:52 UTC,Q9Y6L6,"Mediates the Na(+)-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver","",">Solute carrier organic anion transporter family member 1B1 MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFID GSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLS TCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLG ILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLP QTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVS SYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLS FYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCK SSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIV KIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSS MLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC",SLCO1B1,Solute carrier family 21 member 6; Sodium-independent organic anion-transporting polypeptide 2; OATP 2; OATP-C; Liver-specific organic anion transporter 1; LST-1,691,76450,8.68,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,"PF07648:Kazal_2 PF03137:OATP",HGNC:10959,Basolateral cell membrane,,"","",None,"97-117 207-227 259-279 336-356 376-396 410-430 575-595",Non Essential,"",SLCO1B1,SLCO1B1,AY945934,"","" 1336,16S rRNA,2009-08-11 22:07:48 UTC,2009-08-11 22:07:48 UTC,16S rRNA,,,,,,,,,,,,,,,,,,,,,,,,, 1337,23S rRNA,2009-08-11 22:08:05 UTC,2009-08-11 22:08:05 UTC,23S rRNA,,,,,,,,,,,,,,,,,,,,,,,,, 1338,Toll-like receptor 9,2009-08-11 22:08:06 UTC,2009-08-13 06:39:58 UTC,Q9NR96,"Participates in the innate immune response to microbial agents. Detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response","",">Toll-like receptor 9 MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSL SSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPA LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNN LTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTF SHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVS FAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPE MFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFG MQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGL IWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAG TRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAF MDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEE RDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRY VRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE",TLR9,CD289 antigen,1032,115861,8.23,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF00560:LRR_1 PF01582:TIR",HGNC:15633,Membrane,,"","",1-25,819-839,Non Essential,"",TLR9,TLR9,BC032713,"","" 1339,Farnesyl diphosphate synthase,2009-08-11 22:08:08 UTC,2009-08-11 22:08:08 UTC,Q8WS26,,,,,,,,,,,,,,,,,,,,,,,,, 1340,Acetylcholinesterase,2009-08-11 22:08:14 UTC,2009-08-13 06:39:58 UTC,P04058,Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions,"",">Acetylcholinesterase MNLLVTSSLGVLLHLVVLCQADDHSELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNMRFRRPE PKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGG FYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQEAPGNVGLLDQRMALQWVHDNIQFFGG DPKTVTIFGESAGGASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLNSD EELIHCLREKKPQELIDVEWNVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGS FFLLYGAPGFSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHN VICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNYTAEEEALSRRI MHYWATFAKTGNPNEPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVFWNQFLPKLLNATACDG ELSSSGTSSSKGIIFYVLFSILYLIF",ache,AChE,586,65907,6.00,">>> Function: cholinesterase activity Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: carboxylic ester hydrolase activity Function: carboxylesterase activity Function: acetylcholinesterase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: neurotransmitter metabolism Process: acetylcholine metabolism Process: acetylcholine catabolism Process: acetylcholine catabolism in synaptic cleft || >>> Component: Not Available",Lipid transport and metabolism,PF00135:COesterase,"",Isoform T:Cell membrane,,"","",1-21,None,Essential,1ODC,ache,"",X03439,"","" 1341,30S ribosomal protein S10,2009-08-11 22:08:19 UTC,2009-08-13 06:39:43 UTC,P0A7R5,Involved in the binding of tRNA to the ribosomes,"",">30S ribosomal protein S10 MQNQRIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTH LRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG",rpsJ,"",103,11736,10.34,">>> Function: structural molecule activity Function: structural constituent of ribosome || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: macromolecule biosynthesis Process: protein biosynthesis || >>> Component: small ribosomal subunit Component: protein complex Component: ribonucleoprotein complex Component: ribosome Component: cell Component: intracellular","Translation, ribosomal structure and biogenesis",PF00338:Ribosomal_S10,"","",,"","",None,None,Essential,1P87,rpsJ,"",AF058450,"","" 1342,Oxygen-insensitive NADPH nitroreductase,2009-08-11 22:08:19 UTC,2009-08-13 06:39:42 UTC,P17117,Reduction of nitroaromatic compounds using NADH. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major component of the oxygen- insensitive nitroreductase activity in E.coli,"",">Oxygen-insensitive NADPH nitroreductase MTPTIELICGHRSIRHFTDEPISEAQREAIINSARATSSSSFLQCSSIIRITDKALREELVTLTGGQKHV AQAAEFWVFCADFNRHLQICPDAQLGLAEQLLLGVVDTAMMAQNALIAAESLGLGGVYIGGLRNNIEAVT KLLKLPQHVLPLFGLCLGWPADNPDLKPRLPASILVHENSYQPLDKGALAQYDEQLAEYYLTRGSNNRRD TWSDHIRRTIIKESRPFILDYLHKQGWATR",nfsA,Modulator of drug activity A,240,26801,6.94,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,PF00881:Nitroreductase,"","",,"","",None,None,Essential,1F5V,nfsA,"",X15859,"","" 1343,Probable pyruvate-flavodoxin oxidoreductase,2009-08-11 22:08:20 UTC,2009-08-13 06:39:57 UTC,P52647,Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (Potential),"",">Probable pyruvate-flavodoxin oxidoreductase MITIDGNGAVASVAFRTSEVIAIYPITPSSTMAEQADAWAGNGLKNVWGDTPRVVEMQSEAGAIATVHGA LQTGALSTSFTSSQGLLLMIPTLYKLAGELTPFVLHVAARTVATHALSIFGDHSDVMAVRQTGCAMLCAA NVQEAQDFALISQIATLKSRVPFIHFFDGFRTSHEINKIVPLADDTILDLMPQVEIDAHRARALNPEHPV IRGTSANPDTYFQSREATNPWYNAVYDHVEQAMNDFSAATGRQYQPFEYYGHPQAERVIILMGSAIGTCE EVVDELLTRGEKVGVLKVRLYRPFSAKHLLQALPGSVRSVAVLDRTKEPGAQAEPLYLDVMTALAEAFNN GERETLPRVIGGRYGLSSKEFGPDCVLAVFAELNAAKPKARFTVGIYDDVTNLSLPLPENTLPNSAKLEA LFYGLGSDGSVSATKNNIKIIGNSTPWYAQGYFVYDSKKAGGLTVSHLRVSEQPIRSAYLISQADFVGCH QLQFIDKYQMAERLKPGGIFLLNTPYSADEVWSRLPQEVQAVLNQKKARFYVINAAKIARECGLAARINT VMQMAFFHLTQILPGDSALAELQGAIAKSYSSKGQDLVERNWQALALARESVEEVPLQPVNPHSANRPPV VSDAAPDFVKTVTAAMLAGLGDALPVSALPPDGTWPMGTTRWEKRNIAEEIPIWKEELCTQCNHCVAACP HSAIRAKVVPPEAMENAPASLHSLDVKSRDMRGQKYVLQVAPEDCTGCNLCVEVCPAKDRQNPEIKAINM MSRLEHVEEEKINYDFFLNLPEIDRSKLERIDIRTSQLITPLFEYSGACSGCGETPYIKLLTQLYGDRML IANATGCSSIYGGNLPSTPYTTDANGRGPAWANSLFEDNAEFGLGFRLTVDQHRVRVLRLLDQFADKIPA ELLTALKSDATPEVRREQVAALRQQLNDVAEAHELLRDADALVEKSIWLIGGDGWAYDIGFGGLDHVLSL TENVNILVLDTQCYSNTGGQASKATPLGAVTKFGEHGKRKARKDLGVSMMMYGHVYVAQISLGAQLNQTV KAIQEAEAYPGPSLIIAYSPCEEHGYDLALSHDQMRQLTATGFWPLYRFDPRRADEGKLPLALDSRPPSE APEETLLHEQRFRRLNSQQPEVAEQLWKDAAADLQKRYDFLAQMAGKAEKSNTD",ydbK,"",1174,128826,5.57,">>> Function: vitamin binding Function: thiamin pyrophosphate binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: transporter activity Function: electron transporter activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,"PF00037:Fer4 PF01558:POR PF01855:POR_N PF02775:TPP_enzyme_C","","",,"","",None,None,Essential,"",ydbK,"",AP009048,"","" 1344,ADP/ATP translocase 2,2009-08-11 22:08:22 UTC,2009-08-13 06:39:58 UTC,P05141,Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane,"",">ADP/ATP translocase 2 MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSF WRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTR LAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHI VISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLR GMGGAFVLVLYDEIKKYT",SLC25A5,"Adenine nucleotide translocator 2; ANT 2; ADP,ATP carrier protein 2; Solute carrier family 25 member 5; ADP,ATP carrier protein, fibroblast isoform",298,32896,10.23,">>> Function: binding Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: organelle membrane Component: organelle inner membrane Component: mitochondrial inner membrane","",PF00153:Mito_carr,HGNC:10991,Mitochondrion inner membrane,,"","",None,"5-39 75-100 109-143 176-202 207-241 273-298",Non Essential,1OKC,SLC25A5,SLC25A5,J03591,"","" 1345,ADP/ATP translocase 1,2009-08-11 22:08:22 UTC,2009-08-13 06:39:36 UTC,P12235,Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane,"",">ADP/ATP translocase 1 MGDHAWSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSF WRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTR LAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHI FVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLR GMGGAFVLVLYDEIKKYV",SLC25A4,"Adenine nucleotide translocator 1; ANT 1; ADP,ATP carrier protein 1; Solute carrier family 25 member 4; ADP,ATP carrier protein, heart/skeletal muscle isoform T1",298,33065,10.27,">>> Function: binding Function: transporter activity || >>> Process: intracellular transport Process: mitochondrial transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: mitochondrion Component: cell Component: membrane Component: organelle membrane Component: organelle inner membrane Component: mitochondrial inner membrane","",PF00153:Mito_carr,HGNC:10990,Mitochondrion inner membrane,,"","",None,"5-39 75-100 109-143 176-202 207-241 273-298",Non Essential,1OKC,SLC25A4,SLC25A4,J03593,"","" 1346,ADP/ATP translocase 3,2009-08-11 22:08:23 UTC,2009-08-13 06:39:31 UTC,P12236,Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis,"",">ADP/ATP translocase 3 MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSF WRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTR LAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHI VVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR GMGGAFVLVLYDELKKVI",SLC25A6,"Adenine nucleotide translocator 2; ANT 3; ADP,ATP carrier protein 3; Solute carrier family 25 member 6; ADP,ATP carrier protein, isoform T2",298,32867,10.26,">>> Function: binding Function: transporter activity || >>> Process: intracellular transport Process: mitochondrial transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: mitochondrion Component: cell Component: membrane Component: organelle membrane Component: organelle inner membrane Component: mitochondrial inner membrane","",PF00153:Mito_carr,HGNC:10992,Mitochondrion inner membrane,,"","",None,"5-39 75-100 109-143 176-202 207-241 273-298",Non Essential,1OKC,SLC25A6,SLC25A6,BC031912,"","" 1347,Hydroxyapatite,2009-08-11 22:08:23 UTC,2009-08-11 22:08:23 UTC,Hydroxyapatite,,,,,,,,,,,,,,,,,,,,,,,,, 1348,3-hydroxy-3-methylglutaryl-coenzyme A reductase,2009-08-11 22:09:18 UTC,2009-08-13 06:39:49 UTC,P04035,This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis,"",">3-hydroxy-3-methylglutaryl-coenzyme A reductase MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRC IAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTL AKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMT FFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQ NSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSL KNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHER GVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEG CLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFAR LQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIE GRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQ NVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA",HMGCR,HMG-CoA reductase,888,97477,6.72,">>> Function: hydroxymethylglutaryl-CoA reductase (NADPH) activity Function: hydroxymethylglutaryl-CoA reductase (NADPH) activity Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on CH-OH group of donors Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function: hydroxymethylglutaryl-CoA reductase (NADPH) activity || >>> Process: primary metabolism Process: lipid metabolism Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: organelle membrane Component: endoplasmic reticulum membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Lipid transport and metabolism,PF00368:HMG-CoA_red,HGNC:5006,Endoplasmic reticulum membrane,,"","",None,"10-39 57-78 90-114 124-149 160-187 192-220 315-339",Non Essential,1HWL,HMGCR,HMGCR,BC033692,"","" 1349,Gamma-glutamyltranspeptidase,2009-08-11 22:09:44 UTC,2009-08-13 06:40:00 UTC,P18956,(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid,"",">Gamma-glutamyltranspeptidase MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGG NAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLT SHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFW KEGEPLKKGDTLVQANLAKSLEMIAENGPDEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISG DYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVP WQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVA GESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTGSPGGSRIITT VLQMVVNSIDYGLNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGP DGELYGASDPRSVDDLTAGY",ggt,Contains: RecName: Gamma-glutamyltranspeptidase large chain; Contains: RecName: Gamma-glutamyltranspeptidase small chain,580,61768,5.26,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring amino-acyl groups Function: gamma-glutamyltransferase activity || >>> Process: Not Available || >>> Component: Not Available",Amino acid transport and metabolism,PF01019:G_glu_transpept,"",Periplasm,,"","",1-25,None,Essential,"",ggt,"",U00039,"","" 1350,Antithrombin-III,2009-08-11 22:09:48 UTC,2009-08-13 06:39:32 UTC,P01008,"Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin","",">Antithrombin-III MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQ KIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKF DTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKEN AEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCS ASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVV HMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK",SERPINC1,ATIII,464,52603,6.68,">>> Function: enzyme regulator activity Function: enzyme inhibitor activity Function: protease inhibitor activity Function: endopeptidase inhibitor activity Function: serine-type endopeptidase inhibitor activity || >>> Process: Not Available || >>> Component: Not Available","",PF00079:Serpin,HGNC:775,"Secreted, extracellular space",,REACT_604-Hemostasis;,"",1-32,None,Non Essential,1JVQ,SERPINC1,SERPINC1,M21643,"","" 1351,P-selectin,2009-08-11 22:10:12 UTC,2009-08-13 06:39:41 UTC,P16109,Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1,"",">P-selectin MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYCQNRYTDLVAI QNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPS APGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVL MNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAK AFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSC KFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVL QCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRW TDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCK GIASLPTPGLQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACR AVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQE ALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP",SELP,Granule membrane protein 140; GMP-140; PADGEM; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; CD62 antigen-like family member P; CD62P antigen,830,90834,6.57,">>> Function: binding Function: carbohydrate binding Function: sugar binding || >>> Process: cellular process Process: cell adhesion || >>> Component: cell Component: membrane","","PF00008:EGF PF00059:Lectin_C PF00084:Sushi",HGNC:10721,Membrane,,REACT_604-Hemostasis;,"",1-41,772-795,Non Essential,1G1S,SELP,SELP,CH471067,"","" 1352,Heparanase,2009-08-11 22:10:13 UTC,2009-08-13 06:39:41 UTC,Q9Y251,"Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti- cancer therapies","",">Heparanase MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPR FLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKL RLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDY CSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLK SFLKAGGEVIDSVTWHHYYLNGRTATREDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGG GAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLS KSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI",HPSE,Heparanase-1; Hpa1; Endo-glucoronidase; Contains: RecName: Heparanase 8 kDa subunit; Contains: RecName: Heparanase 50 kDa subunit,543,61177,9.72,"","",PF03662:Glyco_hydro_79n,HGNC:5164,Lysosome membrane,,"","",1-35,None,Non Essential,"",HPSE,HPSE,BC051321,"","" 1353,Low affinity immunoglobulin gamma Fc region receptor III-B,2009-08-11 22:10:14 UTC,2009-08-13 06:39:57 UTC,O75015,"Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils","",">Low affinity immunoglobulin gamma Fc region receptor III-B MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYSVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQ ASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVT YLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAVSTISSFSPPGYQVS FCLVMVLLFAVDTGLYFSVKTNI",FCGR3B,IgG Fc receptor III-1; Fc-gamma RIII-beta; Fc-gamma RIIIb; FcRIIIb; Fc-gamma RIII; FcRIII; FcR-10; CD16b antigen,233,26216,6.71,"","",PF00047:ig,HGNC:3620,Cell membrane,,"","",1-16,None,Non Essential,1E4K,FCGR3B,FCGR3B,Z46223,"","" 1354,Complement C1r subcomponent,2009-08-11 22:10:14 UTC,2009-08-13 06:39:44 UTC,P00736,"C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system","",">Complement C1r subcomponent MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEG CFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQA VDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGYISSLEY PRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSS NAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQV LHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGA LLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIAL LELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRM DVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKE MEEED",C1R,"Complement component 1, r subcomponent; Contains: RecName: Complement C1r subcomponent heavy chain; Contains: RecName: Complement C1r subcomponent light chain",705,80174,6.24,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis || >>> Component: Not Available","","PF00431:CUB PF07645:EGF_CA PF00084:Sushi PF00089:Trypsin",HGNC:1246,Cytoplasmic,,"","",1-17,None,Non Essential,1GPZ,C1R,C1R,BC035220,"","" 1355,Complement C1q subcomponent subunit A,2009-08-11 22:10:14 UTC,2009-08-13 06:39:45 UTC,P02745,"C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes","",">Complement C1q subcomponent subunit A MEGPRGWLVLCVLAISLASMVTEDLCRAPDGKKGEAGRPGRRGRPGLKGEQGEPGAPGIRTGIQGLKGDQ GEPGPSGNPGKVGYPGPSGPLGARGIPGIKGTKGSPGNIKDQPRPAFSAIRRNPPMGGNVVIFDTVITNQ EEPYQNHSGRFVCTVPGYYYFTFQVLSQWEICLSIVSSSRGQVRRSLGFCDTTNKGLFQVVSGGMVLQLQ QGDQVWVEKDPKKGHIYQGSEADSVFSGFLIFPSA",C1QA,"",245,26017,9.45,">>> Function: Not Available || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: phosphate transport || >>> Component: cell Component: intracellular Component: cytoplasm","","PF00386:C1q PF01391:Collagen",HGNC:1241,Secreted,,"","",1-22,None,Non Essential,1PK6,C1QA,C1QA,BC071986,"","" 1356,Complement C1q subcomponent subunit B,2009-08-11 22:10:14 UTC,2009-08-13 06:39:27 UTC,P02746,"C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes","",">Complement C1q subcomponent subunit B MKIPWGSIPVLMLLLLLGLIDISQAQLSCTGPPAIPGIPGIPGTPGPDGQPGTPGIKGEKGLPGLAGDHG EFGEKGDPGIPGNPGKVGPKGPMGPKGGPGAPGAPGPKGESGDYKATQKIAFSATRTINVPLRRDQTIRF DHVITNMNNNYEPRSGKFTCKVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDYAYNTFQVTTGGM VLKLEQGENVFLQATDKNSLLGMEGANSIFSGFLLFPDMEA",C1QB,"",251,26460,8.87,">>> Function: Not Available || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: phosphate transport || >>> Component: cell Component: intracellular Component: cytoplasm","","PF00386:C1q PF01391:Collagen",HGNC:1242,Secreted,,"","",1-25,None,Non Essential,1PK6,C1QB,C1QB,M36278,"","" 1357,Complement C1q subcomponent subunit C,2009-08-11 22:10:15 UTC,2009-08-13 06:39:52 UTC,P02747,"C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes","",">Complement C1q subcomponent subunit C MDVGPSSLPHLGLKLLLLLLLLPLRGQANTGCYGIPGMPGLPGAPGKDGYDGLPGPKGEPGIPAIPGIRG PKGQKGEPGLPGHPGKNGPMGPPGMPGVPGPMGIPGEPGEEGRYKQKFQSVFTVTRQTHQPPAPNSLIRF NAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTANLCVLLYRSGVKVVTFCGHTSKTNQVNSGGVLLR LQVGEEVWLAVNDYYDMVGIQGSDSVFSGFLLFPD",C1QC,"",245,25774,8.58,">>> Function: Not Available || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: phosphate transport || >>> Component: cell Component: intracellular Component: cytoplasm","","PF00386:C1q PF01391:Collagen",HGNC:1245,Secreted,,"","",1-28,None,Non Essential,1PK6,C1QC,C1QC,BC009016,"","" 1358,Low affinity immunoglobulin gamma Fc region receptor III-A,2009-08-11 22:10:15 UTC,2009-08-13 06:40:00 UTC,P08637,"Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis","",">Low affinity immunoglobulin gamma Fc region receptor III-A MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQ ASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVT YLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQVS FCLVMVLLFAVDTGLYFSVKTNIRSSTRDWKDHKFKWRKDPQDK",FCGR3A,IgG Fc receptor III-2; Fc-gamma RIII-alpha; Fc-gamma RIIIa; FcRIIIa; Fc-gamma RIII; FcRIII; FcR-10; CD16a antigen; CD16a antigen,254,29089,8.21,"","",PF00047:ig,HGNC:3619,Cell membrane,,"","",1-16,209-229,Non Essential,1E4K,FCGR3A,FCGR3A,Z46222,"","" 1359,Complement C1s subcomponent,2009-08-11 22:10:15 UTC,2009-08-13 06:39:39 UTC,P09871,"C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4","",">Complement C1s subcomponent MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSV QIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVD VPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEK GFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQK KGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNS KLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPK CVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGST SVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLM DGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKG DSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED",C1S,C1 esterase; Contains: RecName: Complement C1s subcomponent heavy chain; Contains: RecName: Complement C1s subcomponent light chain,688,76685,4.59,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis || >>> Component: Not Available","","PF00431:CUB PF00008:EGF PF00084:Sushi PF00089:Trypsin",HGNC:1247,Cytoplasmic,,"","",1-15,None,Non Essential,1ELV,C1S,C1S,AB009076,"","" 1360,High affinity immunoglobulin gamma Fc receptor I,2009-08-11 22:10:16 UTC,2009-08-13 06:39:28 UTC,P12314,High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses,"",">High affinity immunoglobulin gamma Fc receptor I MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSY RITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRN GKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTL SCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQV LGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEE LKCQEQKEEQLQEGVHRKEPQGAT",FCGR1A,IgG Fc receptor I; Fc-gamma RI; FcRI; CD64 antigen,374,42632,8.08,"","",PF00047:ig,HGNC:3613,Cell membrane,,"","",1-15,293-313,Non Essential,"",FCGR1A,FCGR1A,M91555,"","" 1361,Low affinity immunoglobulin gamma Fc region receptor II-a,2009-08-11 22:10:16 UTC,2009-08-13 06:39:46 UTC,P12318,Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens,"",">Low affinity immunoglobulin gamma Fc region receptor II-a MTMETQMSQNVCPRNLWLLQPLTVLLLLASADSQAAAPPKAVLKLEPPWINVLQEDSVTLTCQGARSPES DSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIM LRCHSWKDKPLVKVTFFQNGKSQKFSHLDPTFSIPQANHSHSGDYHCTGNIGYTLFSSKPVTITVQVPSM GSSSPMGIIVAVVIATAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQLEETNND YETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN",FCGR2A,IgG Fc receptor II-a; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CDw32; CD32 antigen,317,35001,6.67,"","",PF00047:ig,HGNC:3616,Cell membrane,,"","",1-33,218-240,Non Essential,1FCG,FCGR2A,FCGR2A,Y00644,"","" 1362,Low affinity immunoglobulin gamma Fc region receptor II-b,2009-08-11 22:10:16 UTC,2009-08-13 06:40:00 UTC,P31994,"Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis","",">Low affinity immunoglobulin gamma Fc region receptor II-b MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLT CRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHL EFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPV TITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDE ADKVGAENTITYSLLMHPDALEEPDDQNRI",FCGR2B,IgG Fc receptor II-b; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; CDw32; CD32 antigen,310,34044,6.12,"","",PF00047:ig,HGNC:3618,Cell membrane,,"","",1-42,218-240,Non Essential,2FCB,FCGR2B,FCGR2B,AB050934,"","" 1363,Low affinity immunoglobulin gamma Fc region receptor II-c,2009-08-11 22:10:17 UTC,2009-08-13 06:39:49 UTC,P31995,Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells,"",">Low affinity immunoglobulin gamma Fc region receptor II-c MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLT CRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHL EFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPV TITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQP EETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN",FCGR2C,IgG Fc receptor II-c; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CDw32; CD32 antigen,323,35578,6.90,"","",PF00047:ig,HGNC:15626,Isoform IIC1:Cell membrane,,"","",1-42,224-246,Non Essential,2FCB,FCGR2C,FCGR2C,U90941,"","" 1364,B-lymphocyte antigen CD20,2009-08-11 22:10:17 UTC,2009-08-13 06:39:30 UTC,P11836,This protein may be involved in the regulation of B-cell activation and proliferation,"",">B-lymphocyte antigen CD20 MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLL MIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILN IKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAG IVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFP EPPQDQESSPIENDSSP",MS4A1,Membrane-spanning 4-domains subfamily A member 1; B-lymphocyte surface antigen B1; Leu-16; Bp35; CD20 antigen,297,33078,4.73,">>> Function: signal transducer activity Function: receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF04103:CD20,HGNC:7315,Membrane,,"","",None,"64-84 85-105 121-141 189-209",Non Essential,"",MS4A1,MS4A1,BC002807,"","" 1365,Tubulin alpha chain,2009-08-11 22:10:21 UTC,2009-08-13 06:39:36 UTC,P50719,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha chain MREVISIHIGQAGVQIGNACWELYCLEHGIQPDGQMPSDKSLGGCDDSFSTFFSETGSGRHVPRAVMIDL EPTVIDEIRTGTYRSLFHPEQLITGKEDAANNYARGHYTIGKEIIDLTLDRIRRLADNCTGLQGFLVFHS FGGGTGSGFTSLLMERLSVDYGKKAKLEFSVYPAPQVSTAVVEPYNSILTTHTTLEHSDCSFMVDNEAIY DICRRNLDIERPSYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATFSPVISAEK AYHEQLSVAEITNMCFEPHNQMVKCDPRHGKYMAVCLLFRGDVVPKDVNAAIATIKTKRSIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVPRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDLAALEKDYEEVGVDSLEDNGEEGDEY","","",450,50111,4.78,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C","",Cytoplasmic,,"","",None,None,Essential,1SA1,"","",L02108,"","" 1366,Tubulin beta-1 chain,2009-08-11 22:10:21 UTC,2009-08-13 06:39:34 UTC,P18241,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin beta-1 chain MREIVHVQAGQCGNQIGAKFWEVISDEHGVQPDGTYKGDSDLQIERINVYYNEANGGKYVPRAVLVDLEP GTMDSIRGGEFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDNVLDVIRKEAEGCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEYPDRIMSSFSVVPSPKVSDVVLEPYNATLSVHQLVENTDETFCIDNEALYDI CFRTLKLANPTYGDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLSARDAAA YRALNVAELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMREVDEQMMQVQNKNSSYFVEWIPNNVK TAVCDIPPRGLKMSATFIGNTTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATADEEGDLQEGESEYIEQEE","",Beta-1-tubulin,448,50192,4.46,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C","",Cytoplasmic,,"","",None,None,Essential,1SA1,"","",M36380,"","" 1367,Alpha-2C adrenergic receptor,2009-08-11 22:10:23 UTC,2009-08-13 06:40:00 UTC,P18825,Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins,"",">Alpha-2C adrenergic receptor MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNV LVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIV HLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWY ILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPP ADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASS RSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK FFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ",ADRA2C,Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2 adrenergic receptor subtype C4,462,49523,10.69,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity Function: rhodopsin-like receptor activity Function: amine receptor activity Function: adrenoceptor activity Function: alpha-adrenergic receptor activity Function: alpha2-adrenergic receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF00001:7tm_1,HGNC:283,Cell membrane,,"","",None,"52-76 89-114 125-147 169-191 208-231 380-407 421-441",Non Essential,1HOF,ADRA2C,ADRA2C,AY455666,"","" 1368,"Oligopeptide transporter, small intestine isoform",2009-08-11 22:10:23 UTC,2009-08-13 06:39:37 UTC,P46059,Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products,"",">Solute carrier family 15 member 1 MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFVALCYLTPILG ALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLPVHVVLSLIGLALIALGTGGIK PCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMLRVQQCGIHSKQACYPLAFGVPAALMA VALIVFVLGSGMYKKFKPQGNIMGKVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMV TRVMFLYIPLPMFWALFDQQGSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAK CGFNFTSLKKMAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGP MSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQKPEKGENGIRF VNTFNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPPQCQPNFNTFYLEFGSAYTYIVQR KNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGN IIVLIVAGAGQFSKQWAEYILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDEDEKKNRLEKSNPYFMS GANSQKQM",SLC15A1,"Peptide transporter 1; Oligopeptide transporter, small intestine isoform; Intestinal H(+)/peptide cotransporter",708,78807,8.64,">>> Function: transporter activity Function: peptide transporter activity Function: oligopeptide transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: peptide transport Process: oligopeptide transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Amino acid transport and metabolism,PF00854:PTR2,HGNC:10920,Membrane,,"","",None,"1-21 54-74 83-103 119-139 162-182 199-219 277-297 328-348 362-382 585-605 620-640 646-666",Non Essential,"",SLC15A1,SLC15A1,BC096329,"","" 1369,Acriflavine resistance protein B,2009-08-11 22:10:24 UTC,2009-08-13 06:39:57 UTC,P31224,AcrAB is a drug efflux protein with a broad substrate specificity,"",">Acriflavine resistance protein B MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMN GIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVV GVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQ NAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAE FNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIIL VFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTP ALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLP SSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVS LKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARN QLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKK VYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEA MELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVI GALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSL AFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEHSHTVDHH",acrB,"",1049,113575,5.23,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Defense mechanisms,PF00873:ACR_tran,"",Cell inner membrane,,"","",None,"10-28 337-356 366-385 392-413 439-457 466-490 539-555 872-888 899-918 925-943 973-992 999-1018",Essential,1OYE,acrB,"",AP009048,"","" 1370,Calcium signal-modulating cyclophilin ligand,2009-08-11 22:10:25 UTC,2009-08-13 06:39:56 UTC,P49069,Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B,"",">Calcium signal-modulating cyclophilin ligand MESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEESQTKSKQQDS DKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGVAEVKGTQLGDKLDSFIKPPECSSDVNLELRQRNRGDLT ADSVQRGSRHGLEQYLSRFEEAMKLRKQLISEKPSQEDGNTTEEFDSFRIFRLVGCALLALGVRAFVCKY LSIFAPFLTLQLAYMGLYKYFPKSEKKIKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFT FIFCHELLDYWGSEVP",CAMLG,CAML,296,32953,8.19,"","","",HGNC:1471,Membrane,,"","",None,"190-210 241-257",Non Essential,"",CAMLG,CAMLG,AF068179,"","" 1371,Peptidyl-prolyl cis-trans isomerase A,2009-08-11 22:10:25 UTC,2009-08-13 06:39:31 UTC,P62937,PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides,"",">Peptidyl-prolyl cis-trans isomerase A MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRH NGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVE AMERFGSRNGKTSKKITIADCGQLE",PPIA,PPIase A; Rotamase A; Cyclophilin A; Cyclosporin A-binding protein,165,18013,7.97,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein folding || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00160:Pro_isomerase,HGNC:9253,Cytoplasm,,"","",None,None,Non Essential,1CWM,PPIA,PPIA,BC106030,"","" 1372,Photoreceptor,2009-08-11 22:10:25 UTC,2009-08-11 22:10:25 UTC,P93098,,,,,,,,,,,,,,,,,,,,,,,,, 1373,Dihydropyrimidine dehydrogenase [NADP+],2009-08-11 22:10:26 UTC,2009-08-13 06:40:01 UTC,Q12882,Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil,"",">Dihydropyrimidine dehydrogenase [NADP+] MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGER GALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGC NLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLG YSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAF IGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATS ALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTV ESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMI RRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKA DFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQ AVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAI RPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRN CFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLP TITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLSVNPVC",DPYD,DHPDHase; DPD; Dihydrouracil dehydrogenase; Dihydrothymine dehydrogenase,1025,111402,7.05,">>> Function: dihydroorotate dehydrogenase activity Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-CH group of donors Function: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor Function: dihydroorotate oxidase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: transporter activity Function: electron transporter activity || >>> Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleobase metabolism Process: pyrimidine base metabolism Process: pyrimidine base biosynthesis Process: 'de novo' pyrimidine base biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: membrane Component: cell Component: intracellular Component: cytoplasm",Amino acid transport and metabolism,"PF01180:DHO_dh PF00037:Fer4 PF07992:Pyr_redox_2",HGNC:3012,Cytoplasm,,"","",None,None,Non Essential,1GTE,DPYD,DPYD,U57655,"","" 1374,Lymphotoxin-beta,2009-08-11 22:10:27 UTC,2009-08-13 06:39:34 UTC,Q06643,Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional,"",">Lymphotoxin-beta MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLG FQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVG YRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGL VQLRRGERVYVNISHPDMVDFARGKTFFGAVMVG",LTB,LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3,244,25390,5.02,">>> Function: signal transducer activity Function: receptor binding Function: cytokine activity Function: tumor necrosis factor receptor binding || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response || >>> Component: cell Component: membrane","",PF00229:TNF,HGNC:6711,Membrane,,"","",None,19-48,Non Essential,"",LTB,LTB,BC069330,"","" 1375,Tumor necrosis factor receptor superfamily member 1B,2009-08-11 22:10:27 UTC,2009-08-13 06:39:30 UTC,P20333,"Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity","",">Tumor necrosis factor receptor superfamily member 1B MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKT SDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPL RKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMA PGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVN CVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQA PGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQ VPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS",TNFRSF1B,"Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b antigen; Etanercept; Contains: RecName: Tumor necrosis factor receptor superfamily member 1b, membrane form; Contains: RecName: Tumor necrosis factor-binding protein 2; TBPII; TBP-2",461,48291,6.22,">>> Function: signal transducer activity Function: receptor activity || >>> Process: Not Available || >>> Component: Not Available","",PF00020:TNFR_c6,HGNC:11917,Tumor necrosis factor-binding protein 2:Secreted,,"","",1-22,258-287,Non Essential,"",TNFRSF1B,TNFRSF1B,AB030950,"","" 1376,5'-AMP-activated protein kinase subunit beta-1,2009-08-11 22:10:28 UTC,2009-08-13 06:39:49 UTC,Q9Y478,"AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone- sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit","",">5'-AMP-activated protein kinase subunit beta-1 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVN DKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEP IVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHL LQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI",PRKAB1,AMPK beta-1 chain; AMPKb,270,30383,6.37,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on glycosyl bonds Function: hydrolase activity, hydrolyzing O-glycosyl compounds || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: Not Available","","PF04739:AMPKBI PF02922:Isoamylase_N",HGNC:9378,Cytoplasmic,,"","",None,None,Non Essential,"",PRKAB1,PRKAB1,BC017671,"","" 1377,HTH-type transcriptional regulator qacR,2009-08-11 22:10:29 UTC,2009-08-13 06:39:41 UTC,P0A0N5,"Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of qacA (By similarity)","",">HTH-type transcriptional regulator qacR MNLKDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESKWQEQWKKEQI KCKTNREKFYLYNELSLTTEYYYPLQNAIIEFYTEYYKTNSINEKMNKLENKYIDAYHVIFKEGNLNGEW CINDVNAVSKIAANAVNGIVTFTHEQNINERIKLMNKFSQIFLNGLSK",qacR,"",188,22175,8.55,">>> Function: transcription factor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of transcription, DNA-dependent Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription || >>> Component: Not Available",Transcription,"PF08360:TetR_C_5 PF00440:TetR_N","",Cytoplasmic,,"","",None,None,Essential,1QVU,qacR,"",AJ400722,"","" 1378,B-Raf proto-oncogene serine/threonine-protein kinase,2009-08-11 22:10:29 UTC,2009-08-13 06:39:37 UTC,P15056,Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron,"",">B-Raf proto-oncogene serine/threonine-protein kinase MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGG EHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQN PTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGW DTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMC VNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPAD EDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAP TPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQT AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKK RDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH",BRAF,p94; v-Raf murine sarcoma viral oncogene homolog B1,766,84438,7.58,">>> Function: protein serine/threonine kinase activity Function: signal transducer activity Function: receptor signaling protein activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00069:Pkinase PF02196:RBD",HGNC:1097,Cytoplasm,,"","",None,None,Non Essential,1UWJ,BRAF,BRAF,M21001,"","" 1379,FL cytokine receptor,2009-08-11 22:10:29 UTC,2009-08-13 06:40:00 UTC,P36888,Receptor for the FL cytokine. Has a tyrosine-protein kinase activity,"",">FL cytokine receptor MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQ SSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGE YLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEES PAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHG FGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFI NATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRK VFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTL LICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAY GISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLL NYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYEN QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQ PFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMD LGLLSPQAQVEDS",FLT3,Tyrosine-protein kinase receptor FLT3; Stem cell tyrosine kinase 1; STK-1; CD135 antigen,993,112904,5.43,">>> Function: protein-tyrosine kinase activity Function: transmembrane receptor protein tyrosine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: enzyme linked receptor protein signaling pathway Process: transmembrane receptor protein tyrosine kinase signaling pathway Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: cell Component: membrane","","PF00047:ig PF07714:Pkinase_Tyr",HGNC:3765,Membrane,,"","",1-26,544-563,Non Essential,"",FLT3,FLT3,L36162,"","" 1380,RAF proto-oncogene serine/threonine-protein kinase,2009-08-11 22:10:29 UTC,2009-08-13 06:39:50 UTC,P04049,Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3,"",">RAF proto-oncogene serine/threonine-protein kinase MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVV NVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHN FARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALP SLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDA IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVM LSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA TVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFM VGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAH TEDINACTLTTSPRLPVF",RAF1,C-RAF; cRaf; Raf-1,648,73052,9.62,">>> Function: protein serine/threonine kinase activity Function: signal transducer activity Function: receptor signaling protein activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00069:Pkinase PF02196:RBD",HGNC:9829,"",,"","",None,None,Non Essential,"",RAF1,RAF1,L00212,"","" 1381,Vascular endothelial growth factor receptor 3,2009-08-11 22:10:29 UTC,2009-08-13 06:39:49 UTC,P35916,Receptor for VEGFC. Has a tyrosine-protein kinase activity,"",">Vascular endothelial growth factor receptor 3 MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPAT GDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFI NKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTW GDQDFLSNPFLVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVP ERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDE LVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNV PPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWR AVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTI ESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPG ARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCL VAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSED KGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF PRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVV NLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRV LFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDV VKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQI NEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRS SQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPM TPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFR",FLT4,VEGFR-3; Tyrosine-protein kinase receptor FLT4,1298,145600,6.24,">>> Function: vascular endothelial growth factor receptor activity Function: protein-tyrosine kinase activity Function: transmembrane receptor protein tyrosine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: enzyme linked receptor protein signaling pathway Process: transmembrane receptor protein tyrosine kinase signaling pathway Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: cell Component: membrane","","PF07679:I-set PF00047:ig PF07714:Pkinase_Tyr",HGNC:3767,Membrane,,"","",1-24,776-797,Non Essential,"",FLT4,FLT4,U43143,"","" 1382,Beta platelet-derived growth factor receptor,2009-08-11 22:10:30 UTC,2009-08-13 06:39:43 UTC,P09619,Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2,"",">Beta-type platelet-derived growth factor receptor MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPP QEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLT EITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQ VSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPS AELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLW FKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVL ELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFE VVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKP RYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMK VAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTF LQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSN YMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMN EQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRS DHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLN EVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL",PDGFRB,PDGF-R-beta; CD140 antigen-like family member B; CD140b antigen,1106,123969,4.62,">>> Function: vascular endothelial growth factor receptor activity Function: protein-tyrosine kinase activity Function: transmembrane receptor protein tyrosine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: enzyme linked receptor protein signaling pathway Process: transmembrane receptor protein tyrosine kinase signaling pathway Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: cell Component: membrane","","PF00047:ig PF07714:Pkinase_Tyr",HGNC:8804,Membrane,,"","",1-32,532-556,Non Essential,"",PDGFRB,PDGFRB,U33172,"","" 1383,Mast/stem cell growth factor receptor,2009-08-11 22:10:30 UTC,2009-08-13 06:39:56 UTC,P10721,This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K),"",">Mast/stem cell growth factor receptor MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEI LDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTD PEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKA VPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSA RVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIY MNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVE CKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVV EEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAH LTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEA ALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLL SFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDAD PLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV",KIT,SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 antigen,976,109866,6.96,">>> Function: vascular endothelial growth factor receptor activity Function: protein-tyrosine kinase activity Function: transmembrane receptor protein tyrosine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: enzyme linked receptor protein signaling pathway Process: transmembrane receptor protein tyrosine kinase signaling pathway Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: cell Component: membrane","","PF00047:ig PF07714:Pkinase_Tyr",HGNC:6342,Membrane,,"","",1-25,525-545,Non Essential,"",KIT,KIT,S67773,"","" 1384,Vascular endothelial growth factor receptor 2,2009-08-11 22:10:30 UTC,2009-08-13 06:39:30 UTC,P35968,"Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions","",">Vascular endothelial growth factor receptor 2 MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGS EQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITE NKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQ SIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQ SGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRI PAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVED FQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQ PTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELK NASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMW FKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVG TAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPL GRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGG PLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEE KSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLK EGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDS GLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDS GMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLI EIGVQTGSTAQILQPDSGTTLSSPPV",KDR,VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; CD309 antigen,1356,151528,5.64,">>> Function: vascular endothelial growth factor receptor activity Function: protein-tyrosine kinase activity Function: transmembrane receptor protein tyrosine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: enzyme linked receptor protein signaling pathway Process: transmembrane receptor protein tyrosine kinase signaling pathway Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: cell Component: membrane","","PF07679:I-set PF07714:Pkinase_Tyr PF07686:V-set",HGNC:6307,Membrane,,"","",1-19,765-789,Non Essential,"",KDR,KDR,X89776,"","" 1385,Nuclear factor NF-kappa-B p105 subunit,2009-08-11 22:10:31 UTC,2009-08-13 06:39:33 UTC,P19838,"NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post- translationally. p50 binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105","",">Nuclear factor NF-kappa-B p105 subunit MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYVCEGPSHGGLP GASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLG ILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLS VVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDI QIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYY PEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTK EESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVR DLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKV LSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISL AGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVV PGTTPLDMATSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPAS TRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGKI",NFKB1,DNA-binding factor KBF1; EBP-1; Contains: RecName: Nuclear factor NF-kappa-B p50 subunit,968,105357,5.05,">>> Function: nucleic acid binding Function: DNA binding Function: transcription factor activity Function: binding Function: protein binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cellular process Process: cell communication Process: signal transduction || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00023:Ank PF00531:Death PF00554:RHD PF01833:TIG",HGNC:7794,Nucleus. Cytoplasm,,"","",None,None,Non Essential,1SVC,NFKB1,NFKB1,BC051765,"","" 1386,Thymidine kinase,2009-08-11 22:10:31 UTC,2009-08-13 06:39:39 UTC,Q9QNF7,"In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity)","",">Thymidine kinase MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRLEQKMPTLLRVYIDGPHGMGKTTTTQLLV ALGSRDDIVYVPEPMTYWQVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLA PHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPE DRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGP RPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQT HVTTPGSIPTICDLARTFAREMGEAN",TK,"",376,40897,7.70,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: nucleobase, nucleoside, nucleotide kinase activity Function: nucleoside kinase activity Function: deoxynucleoside kinase activity Function: thymidine kinase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: pyrimidine nucleotide metabolism Process: pyrimidine nucleotide biosynthesis Process: pyrimidine nucleoside monophosphate biosynthesis Process: pyrimidine ribonucleoside monophosphate biosynthesis Process: TMP biosynthesis || >>> Component: Not Available","",PF00693:Herpes_TK,"","",,"","",None,None,Non Essential,1OF1,TK,"",AB047378,"","" 1387,DNA polymerase,2009-08-11 22:10:32 UTC,2009-08-13 06:39:48 UTC,P04293,Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1),"",">DNA polymerase MFSGGGGPLSPGGKSAARAASGFFAPAGPRGASRGPPPCLRQNFYNPYLAPVGTQQKPTGPTQRHTYYSE CDEFRFIAPRVLDEDAPPEKRAGVHDGHLKRAPKVYCGGDERDVLRVGSGGFWPRRSRLWGGVDHAPAGF NPTVTVFHVYDILENVEHAYGMRAAQFHARFMDAITPTGTVITLLGLTPEGHRVAVHVYGTRQYFYMNKE EVDRHLQCRAPRDLCERMAAALRESPGASFRGISADHFEAEVVERTDVYYYETRPALFYRVYVRSGRVLS YLCDNFCPAIKKYEGGVDATTRFILDNPGFVTFGWYRLKPGRNNTLAQPAAPMAFGTSSDVEFNCTADNL AIEGGMSDLPAYKLMCFDIECKAGGEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFSLGSCDLP ESHLNELAARGLPTPVVLEFDSEFEMLLAFMTLVKQYGPEFVTGYNIINFDWPFLLAKLTDIYKVPLDGY GRMNGRGVFRVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLKDKKKDLSYRDI PAYYAAGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINITRTIYDGQQIRVFTCLLRLAD QKGFILPDTQGRFRGAGGEAPKRPAAAREDEERPEEEGEDEDEREEGGGEREPEGARETAGRHVGYQGAR VLDPTSGFHVNPVVVFDFASLYPSIIQAHNLCFSTLSLRADAVAHLEAGKDYLEIEVGGRRLFFVKAHVR ESLLSILLRDWLAMRKQIRSRIPQSSPEEAVLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTI GREMLLATREYVHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLTAVGDKMA SHISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIKGVDLVRKNNCAFINRTSRALVDLLFYD DTVSGAAAALAERPAEEWLARPLPEGLQAFGAVLVDAHRRITDPERDIQDFVLTAELSRHPRAYTNKRLA HLTVYYKLMARRAQVPSIKDRIPYVIVAQTREVEETVARLAALRELDAAAPGDEPAPPAALPSPAKRPRE TPSPADPPGGASKPRKLLVSELAEDPAYAIAHGVALNTDYYFSHLLGAACVTFKALFGNNAKITESLLKR FIPEVWHPPDDVAARLRTAGFGAVGAGATAEETRRMLHRAFDTLA",UL30,"",1235,136422,7.31,">>> Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: nuclease activity Function: exonuclease activity Function: 3'-5' exonuclease activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed DNA polymerase activity Function: nucleic acid binding Function: DNA binding Function: binding Function: nucleotide binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA replication || >>> Component: Not Available","Replication, recombination and repair","PF00136:DNA_pol_B PF03104:DNA_pol_B_exo","",Nucleus,,"","",None,None,Non Essential,"",UL30,"",X03181,"","" 1388,Glycosyltransferase GtfA,2009-08-11 22:10:32 UTC,2009-08-13 06:39:30 UTC,P96558,"","",">Glycosyltransferase GtfA (PCZA361.19) MRVLITGCGSRGDTEPLVALAARLRELGADARMCLPPDYVERCAEVGVPMVPVGRAVRAGAREPGELPPG AAEVVTEVVAEWFDKVPAAIEGCDAVVTTGLLPAAVAVRSMAEKLGIPYRYTVLSPDHLPSEQSQAERDM YNQGADRLFGDAVNSHRASIGLPPVEHLYDYGYTDQPWLAADPVLSPLRPTDLGTVQTGAWILPDERPLS AELEAFLAAGSTPVYVGFGSSSRPATADAAKMAIKAVRASGRRIVLSRGWADLVLPDDGADCFVVGEVNL QELFGRVAAAIHHDSAGTTLLAMRAGIPQIVVRRVVDNVVEQAYHADRVAELGVGVAVDGPVPTIDSLSA ALDTALAPEIRARATTVADTIRADGTTVAAQLLFDAVSLEKPTVPA",gtfA,"",396,41663,4.56,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring hexosyl groups || >>> Process: biopolymer metabolism Process: biopolymer modification Process: lipid modification Process: lipid glycosylation Process: physiological process Process: metabolism Process: macromolecule metabolism Process: carbohydrate metabolism || >>> Component: Not Available",Carbohydrate transport and metabolism,PF03033:Glyco_transf_28,"","",,"","",None,None,Essential,1PNV,gtfA,"",AJ223998,"","" 1389,Neuromedin-K receptor,2009-08-12 21:34:27 UTC,2009-08-12 21:34:27 UTC,P29371,,,,,,,,,,,,,,,,,,,,,,,,, 1390,Dual specificity mitogen-activated protein kinase kinase 1,2009-08-12 21:34:27 UTC,2009-08-12 21:34:27 UTC,Q02750,,,,,,,,,,,,,,,,,,,,,,,,, 1391,Dual specificity mitogen-activated protein kinase kinase 2,2009-08-12 21:34:27 UTC,2009-08-12 21:34:27 UTC,P36507,,,,,,,,,,,,,,,,,,,,,,,,, 1392,Dual specificity mitogen-activated protein kinase kinase 3,2009-08-12 21:34:28 UTC,2009-08-12 21:34:28 UTC,P46734,,,,,,,,,,,,,,,,,,,,,,,,, 1393,Dual specificity mitogen-activated protein kinase kinase 4,2009-08-12 21:34:28 UTC,2009-08-12 21:34:28 UTC,P45985,,,,,,,,,,,,,,,,,,,,,,,,, 1394,Dual specificity mitogen-activated protein kinase kinase 5,2009-08-12 21:34:28 UTC,2009-08-12 21:34:28 UTC,Q13163,,,,,,,,,,,,,,,,,,,,,,,,, 1395,Dual specificity mitogen-activated protein kinase kinase 6,2009-08-12 21:34:28 UTC,2009-08-12 21:34:28 UTC,P52564,,,,,,,,,,,,,,,,,,,,,,,,, 1396,Dual specificity mitogen-activated protein kinase kinase 7,2009-08-12 21:34:28 UTC,2009-08-12 21:34:28 UTC,O14733,,,,,,,,,,,,,,,,,,,,,,,,, 1397,"Guanine nucleotide-binding protein G(i), alpha-1 subunit ",2009-08-12 21:34:30 UTC,2009-08-12 21:34:30 UTC,P63096,,,,,,,,,,,,,,,,,,,,,,,,, 1398,"Guanine nucleotide-binding protein G(i), alpha-2 subunit ",2009-08-12 21:34:30 UTC,2009-08-12 21:34:31 UTC,P04899,,,,,,,,,,,,,,,,,,,,,,,,, 1399,Guanine nucleotide-binding protein G(o) subunit alpha,2009-08-12 21:34:31 UTC,2009-08-12 21:34:31 UTC,P09471,,,,,,,,,,,,,,,,,,,,,,,,, 1400,Guanine nucleotide-binding protein G(t) subunit alpha-1 ,2009-08-12 21:34:31 UTC,2009-08-12 21:34:31 UTC,P11488,,,,,,,,,,,,,,,,,,,,,,,,, 1401,Guanine nucleotide-binding protein G(t) subunit alpha-2 ,2009-08-12 21:34:31 UTC,2009-08-12 21:34:31 UTC,P19087,,,,,,,,,,,,,,,,,,,,,,,,, 1402,Guanine nucleotide-binding protein G(t) subunit alpha-3 ,2009-08-12 21:34:31 UTC,2009-08-12 21:34:31 UTC,A8MTJ3,,,,,,,,,,,,,,,,,,,,,,,,, 1403,Cell division control protein 42 homolog,2009-08-12 21:34:31 UTC,2009-08-12 21:34:31 UTC,P60953,,,,,,,,,,,,,,,,,,,,,,,,, 1404,Rho-related GTP-binding protein RhoQ ,2009-08-12 21:34:32 UTC,2009-08-12 21:34:32 UTC,P17081,,,,,,,,,,,,,,,,,,,,,,,,, 1405,Rho-related GTP-binding protein RhoJ,2009-08-12 21:34:32 UTC,2009-08-12 21:34:32 UTC,Q9H4E5,,,,,,,,,,,,,,,,,,,,,,,,, 1406,Rho-related GTP-binding protein RhoU,2009-08-12 21:34:32 UTC,2009-08-12 21:34:32 UTC,Q7L0Q8,,,,,,,,,,,,,,,,,,,,,,,,, 1407,Rho-related GTP-binding protein RhoV,2009-08-12 21:34:32 UTC,2009-08-12 21:34:32 UTC,Q96L33,,,,,,,,,,,,,,,,,,,,,,,,, 1408,Ras-related C3 botulinum toxin substrate 1 ,2009-08-12 21:34:32 UTC,2009-08-12 21:34:32 UTC,P63000,,,,,,,,,,,,,,,,,,,,,,,,, 1409,Ras-related C3 botulinum toxin substrate 2,2009-08-12 21:34:32 UTC,2009-08-12 21:34:32 UTC,P15153,,,,,,,,,,,,,,,,,,,,,,,,, 1410,Ras-related C3 botulinum toxin substrate 3,2009-08-12 21:34:33 UTC,2009-08-12 21:34:33 UTC,P60763,,,,,,,,,,,,,,,,,,,,,,,,, 1411,Rho-related GTP-binding protein RhoG,2009-08-12 21:34:33 UTC,2009-08-12 21:34:33 UTC,P84095,,,,,,,,,,,,,,,,,,,,,,,,, 1412,Rho-related BTB domain-containing protein 1,2009-08-12 21:34:33 UTC,2009-08-12 21:34:33 UTC,O94844,,,,,,,,,,,,,,,,,,,,,,,,, 1413,Rho-related BTB domain-containing protein 2 ,2009-08-12 21:34:33 UTC,2009-08-12 21:34:33 UTC,Q9BYZ6,,,,,,,,,,,,,,,,,,,,,,,,, 1414,Rho-related GTP-binding protein RhoH,2009-08-12 21:34:33 UTC,2009-08-12 21:34:33 UTC,Q15669,,,,,,,,,,,,,,,,,,,,,,,,, 1415,Transforming protein RhoA,2009-08-12 21:34:34 UTC,2009-08-12 21:34:34 UTC,P61586,,,,,,,,,,,,,,,,,,,,,,,,, 1416,Rho-related GTP-binding protein RhoB,2009-08-12 21:34:34 UTC,2009-08-12 21:34:34 UTC,P62745,,,,,,,,,,,,,,,,,,,,,,,,, 1417,Rho-related GTP-binding protein RhoC,2009-08-12 21:34:34 UTC,2009-08-12 21:34:34 UTC,P08134,,,,,,,,,,,,,,,,,,,,,,,,, 1418,Rho-related GTP-binding protein Rho6,2009-08-12 21:34:34 UTC,2009-08-12 21:34:34 UTC,Q92730,,,,,,,,,,,,,,,,,,,,,,,,, 1419,Rho-related GTP-binding protein RhoN,2009-08-12 21:34:34 UTC,2009-08-12 21:34:34 UTC,P52198,,,,,,,,,,,,,,,,,,,,,,,,, 1420,Rho-related GTP-binding protein RhoE,2009-08-12 21:34:34 UTC,2009-08-12 21:34:34 UTC,P61587,,,,,,,,,,,,,,,,,,,,,,,,, 1421,Rho-related GTP-binding protein RhoD,2009-08-12 21:34:35 UTC,2009-08-12 21:34:35 UTC,O00212,,,,,,,,,,,,,,,,,,,,,,,,, 1422,Rho-related GTP-binding protein RhoF ,2009-08-12 21:34:35 UTC,2009-08-12 21:34:35 UTC,Q9HBH0,,,,,,,,,,,,,,,,,,,,,,,,, 1423,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,2009-08-12 21:34:37 UTC,2009-08-12 21:34:37 UTC,P63092,,,,,,,,,,,,,,,,,,,,,,,,, 1424,Guanine nucleotide-binding protein G(s) subunit alpha isoforms Xlas,2009-08-12 21:34:38 UTC,2009-08-12 21:34:38 UTC,Q5JWF2,,,,,,,,,,,,,,,,,,,,,,,,, 1425,Vesicle-associated membrane protein 2 ,2009-08-12 21:34:38 UTC,2009-08-12 21:34:38 UTC,P63027,,,,,,,,,,,,,,,,,,,,,,,,, 1426,Guanine nucleotide-binding protein G(q) subunit alpha ,2009-08-12 21:34:38 UTC,2009-08-12 21:34:38 UTC,P50148,,,,,,,,,,,,,,,,,,,,,,,,, 1427,Guanine nucleotide-binding protein subunit alpha-13 ,2009-08-12 21:34:38 UTC,2009-08-12 21:34:38 UTC,Q14344,,,,,,,,,,,,,,,,,,,,,,,,, 1428,Guanine nucleotide-binding protein subunit alpha-12 ,2009-08-12 21:34:39 UTC,2009-08-12 21:34:39 UTC,Q03113,,,,,,,,,,,,,,,,,,,,,,,,, 1429,Elongation factor 2,2009-08-12 21:34:39 UTC,2009-08-12 21:34:39 UTC,P32324,,,,,,,,,,,,,,,,,,,,,,,,, 1430,Cholesterol,2009-08-12 21:34:40 UTC,2009-08-12 21:34:40 UTC,Cholesterol,,,,,,,,,,,,,,,,,,,,,,,,, 1431,DNA-directed RNA polymerase II subunit RPB1 ,2009-08-12 21:42:37 UTC,2009-08-13 06:39:49 UTC,Q9FBI2,"The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subnit is cleaved by furin in two fragments, A1 and A2:A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits","",">Shiga toxin subunit A MKIIIFRVLTFFFVIFSVNVVAKEFTLDFSTAKTYVDSLNVIRSAIGTPLQTISSGGTSLLMIDSGTGDN LFAVDVRGIDPEEGRFNNLRLIVERNNLYVTGFVNRTNNVFYRFADFSHVTFPGTTAVTLSGDSSYTTLQ RVAGISRTGMQINRHSLTTSYLDLMSHSGTSLTQSVARAMLRFVTVTAEALRFRQIQRGFRTTLDDLSGR SYVMTAEDVDLTLNWGRLSSVLPDYHGQDSVRVGRISFGSINAILGSVALILNCHHHASRVARMASDEFP SMCPADGRVRGITHNKILWDSSTLGAILMRRTISS",stxA,"",315,34814,9.88,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on glycosyl bonds Function: hydrolase activity, hydrolyzing N-glycosyl compounds Function: RNA glycosylase activity Function: rRNA N-glycosylase activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of biosynthesis Process: regulation of cellular biosynthesis Process: regulation of protein biosynthesis Process: negative regulation of protein biosynthesis || >>> Component: Not Available","",PF00161:RIP,"",Cytoplasmic,,"","",1-22,None,Essential,1R4Q,stxA,"",AJ271153,"","" 1432,Choline/ethanolaminephosphotransferase 1,2009-08-13 17:40:57 UTC,2009-08-13 17:40:57 UTC,Q9Y6K0,,,,,,,,,,,,,,,,,,,,,,,,, 1433,Corticosteroid 11-beta-dehydrogenase isozyme 2,2009-08-14 16:24:18 UTC,2009-08-14 16:28:20 UTC,P80365,"Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.","",">Corticosteroid 11-beta-dehydrogenase isozyme 2 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR","HSD11B2 HSD11K",11-beta-hydroxysteroid dehydrogenase type 2,405,"","","","","","","","",,,,,,,,,,,