id,name,created_at,updated_at,uniprot,description,genesequence,proteinsequence,gene_name,synonyms,number_of_residues,molecular_weight,theoretical_pi,go_classification,general_function,domain_function,hgnc_id,cellular_location,genbank_id,pathway,reaction,signals,transmembrane_regions,essentiality,pdb_id,genecard_id,genatlas_id,genbank_id_gene,chromosome_location,locus 2,"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial",2009-03-06 21:37:32 UTC,2009-06-30 03:51:39 UTC,P29803,"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)","",">Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial MLAAFISRVLRRVAQKSARRVLVASRNSSNDATFEIKKCDLYLLEEGPPVTTVLTRAEGLKYYRMMLTVR RMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHGVCYTRGLSVRSILAELTGRR GGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACKYKGNDEICLTLYGDGAANQGQIAEAFNMAA LWKLPCVFICENNLYGMGTSTERAAASPDYYKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILM ELQTYRYHGHSMSDPGVSYRTREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQF ATTDPEPHLEELGHHIYSSDSSFEVRGANPWIKFKSVS",PDHA2,PDHE1-A type II,388,42934,8.56,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Energy production and conversion,PF00676:E1_dh,HGNC:8807,Mitochondrion matrix,"","","",None,None,Non Essential,"",PDHA2,PDHA2,BC127638,"","" 3,Hemoglobin subunit beta,2009-03-30 19:57:52 UTC,2009-06-30 03:51:47 UTC,P68871,"LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure","",">Hemoglobin subunit beta MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLG AFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVAN ALAHKYH",HBB,Hemoglobin beta chain; Beta-globin; Contains: RecName: LVV-hemorphin-7,147,15999,7.32,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4827,"",,"","",None,None,Non Essential,1DXT,HBB,HBB,L48932,Chromosome:11,11p15.5 4,Hemoglobin subunit alpha,2009-03-31 23:06:30 UTC,2009-06-30 03:51:44 UTC,P69905,Involved in oxygen transport from the lung to the various peripheral tissues,"",">Hemoglobin subunit alpha MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNA VAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSK YR",HBA1,Hemoglobin alpha chain; Alpha-globin,142,15258,9.09,">>> Function: oxygen binding Function: binding || >>> Process: gas transport Process: oxygen transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4823,"",,"","",None,None,Non Essential,1Y01,HBA1,HBA1,BC101848,Chromosome:16,16p13.3 5,Estrogen receptor,2009-04-01 00:20:35 UTC,2009-06-30 03:51:47 UTC,P03372,Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues,"",">Estrogen receptor MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANA QVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYT VREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFK RSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEV GSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLA DRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLM AKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASV EETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV",ESR1,ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1,595,66217,8.14,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF02159:Oest_recep PF00105:zf-C4",HGNC:3467,Nucleus,,"","",None,None,Non Essential,1R5K,ESR1,ESR1,Z75126,"","" 6,Glucocorticoid receptor,2009-04-01 00:23:57 UTC,2009-06-30 03:51:37 UTC,P04150,"Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity)","",">Glucocorticoid receptor MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSV SNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPK SSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNE SPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEK EDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPI FNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEA RKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIM TTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIIN EQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKA IVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIK KLLFHQK",NR3C1,GR; Nuclear receptor subfamily 3 group C member 1,777,85660,6.31,">>> Function: transcription factor activity Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: glucocorticoid receptor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF02155:GCR PF00104:Hormone_recep PF00105:zf-C4",HGNC:7978,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1NHZ,NR3C1,NR3C1,S68378,"","" 7,"Glutathione reductase, mitochondrial",2009-04-01 00:33:59 UTC,2009-06-30 03:51:46 UTC,P00390,Maintains high levels of reduced glutathione in the cytosol,"",">Glutathione reductase, mitochondrial MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVI GGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNW RVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHES QIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTE ELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQ TDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQG FAVAVKMGATKADFDNTVAIHPTSSEELVTLR",GSR,GRase; GR,522,56258,8.66,">>> Function: disulfide oxidoreductase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: catalytic activity Function: oxidoreductase activity Function: transporter activity Function: electron transporter activity Function: glutathione-disulfide reductase activity || >>> Process: generation of precursor metabolites and energy Process: electron transport Process: physiological process Process: metabolism Process: cellular metabolism Process: cofactor metabolism Process: coenzyme metabolism Process: glutathione metabolism || >>> Component: cell Component: intracellular Component: cytoplasm",RNA processing and modification,"PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim",HGNC:4623,Mitochondrion. Cytoplasm,,"","",None,None,Non Essential,1BWC,GSR,GSR,BC069244,"","" 8,Kelch-like ECH-associated protein 1,2009-04-01 16:08:39 UTC,2009-06-30 03:51:38 UTC,Q14145,"Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome","",">Kelch-like ECH-associated protein 1 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNEL RLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFA YTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMH FGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNF LQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDG TWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECY YPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGIT VHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC",KEAP1,Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19,624,69667,6.42,">>> Function: binding Function: protein binding || >>> Process: Not Available || >>> Component: Not Available","","PF07707:BACK PF00651:BTB PF01344:Kelch_1",HGNC:23177,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1U6D,KEAP1,KEAP1,BC015945,Chromosome:19,19p13.2 9,Poly [ADP-ribose] polymerase 1,2009-04-01 16:10:46 UTC,2009-06-30 03:51:45 UTC,P09874,"Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks","",">Poly [ADP-ribose] polymerase 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVE VDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLS KKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKG DEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAIL DRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKV KKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPV EVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLV DIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN FTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGK LSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLD IEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHT SQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVN DTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW",PARP1,PARP-1; ADPRT; NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1,1014,113085,9.34,">>> Function: NAD+ ADP-ribosyltransferase activity Function: NAD+ ADP-ribosyltransferase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring pentosyl groups Function: NAD+ ADP-ribosyltransferase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid ADP-ribosylation Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: cell Component: intracellular","","PF00533:BRCT PF08063:PADR1 PF00644:PARP PF02877:PARP_reg PF05406:WGR PF00645:zf-PARP",HGNC:270,Nucleus,,"","",None,None,Non Essential,1WOK,PARP1,PARP1,M17081,"","" 10,Thioredoxin,2009-04-01 16:13:26 UTC,2009-06-30 03:51:44 UTC,P10599,ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55),"",">Thioredoxin MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECE VKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV",TXN,Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP,105,11738,4.55,">>> Function: transporter activity Function: electron transporter activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00085:Thioredoxin,HGNC:12435,Cytoplasm,,"","",None,None,Non Essential,1ERU,TXN,TXN,BC054866,"","" 11,Tubulin beta chain,2009-04-01 16:15:58 UTC,2009-06-30 03:51:47 UTC,P07437,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin beta chain MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEP GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK TAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEEEDFGEEAEEEA",TUBB,Tubulin beta-5 chain,444,49671,4.52,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20778,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB,TUBB,BC070326,"","" 12,"Actin, cytoplasmic 1",2009-04-01 16:19:34 UTC,2009-06-30 03:51:40 UTC,P60709,Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells,"",">Actin, cytoplasmic 1 MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYP IEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVL SLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVR DIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFN SIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLS TFQQMWISKQEYDESGPSIVHRKCF",ACTB,Beta-actin,375,41737,5.15,">>> Function: binding Function: protein binding Function: structural molecule activity Function: structural constituent of cytoskeleton Function: motor activity || >>> Process: Not Available || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: actin cytoskeleton Component: actin filament",Cytoskeleton,PF00022:Actin,HGNC:132,"Cytoplasm, cytoskeleton",,"","",None,None,Non Essential,1HLU,ACTB,ACTB,V00478,"","" 13,Ig heavy chain V-I region WOL,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P01760,"","",">Ig heavy chain V-I region WOL QVQLMQSGAEVKKPGSSVRVSCKTSGGTFVDYKGLWVRQAPGKGLEWVGQIPLRFNGEVKNPGSVVRVSV SLKPSFNQAHMELSSLFSEDTAVYYCAREYGFDTSDYYYYYWGQGTLVTVSSGS","","",124,13684,8.63,"","",PF00047:ig,"","",,"","",None,None,Non Essential,"","","","","","" 14,Ig kappa chain V-I region Roy,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P01608,"","",">Ig kappa chain V-I region Roy DIQMTQSPSSLSASVGDRVTITCQASQDISIFLNWYQQKPGKAPKLLIYDASKLEAGVPSRFSGTGSGTD FTFTISSLQPEDIATYYCQQFDNLPLTFGGGTKVDFKR","","",108,11782,4.93,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,1B6D,"","","","","" 15,Mitogen-activated protein kinase 8,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P45983,"JNK1 isoforms display different binding patterns:beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta- 2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms","",">Mitogen-activated protein kinase 8 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRA YRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWS VGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLF PADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIE EWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA GPLGCCR",MAPK8,Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; JNK-46,427,48296,6.89,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6881,"",,REACT_578-Apoptosis;,"",None,None,Non Essential,1UKI,MAPK8,MAPK8,U35005,Chromosome:10,10q11.22 16,Protein kinase C eta type,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P24723,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters","",">Protein kinase C eta type MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYNE EFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELRGTTGASDTFEGWVDLEPEGKVFVVITLTGSF TEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVV HKRCHHLIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICK MNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRL GIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHE GHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENED DLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP FRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQP",PRKCH,nPKC-eta; PKC-L,683,77773,7.80,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9403,"",,"","",None,None,Non Essential,"",PRKCH,PRKCH,S74620,Chromosome:14,14q22-q23 17,Ribonucleoside-diphosphate reductase subunit M2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P31350,Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling,"",">Ribonucleoside-diphosphate reductase subunit M2 MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDE PLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGI VNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWA LRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHL VHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFM ENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF",RRM2,Ribonucleotide reductase small subunit; Ribonucleotide reductase small chain,389,44878,5.05,">>> Function: oxidoreductase activity, acting on CH2 groups Function: oxidoreductase activity, acting on CH2 groups, disulfide as acceptor Function: ribonucleoside-diphosphate reductase activity Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleoside diphosphate metabolism Process: deoxyribonucleoside diphosphate metabolism || >>> Component: Not Available",Nucleotide transport and metabolism,PF00268:Ribonuc_red_sm,HGNC:10452,Cytoplasm,,"","",None,None,Non Essential,1H0N,RRM2,RRM2,BC030154,"","" 18,Calmodulin,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P62158,"Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis","",">Calmodulin MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFL TMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYE EFVQMMTAK",CALM1,CaM,149,16838,3.84,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: Not Available || >>> Component: Not Available","",PF00036:efhand,HGNC:1442,Spindle,,"","",None,None,Non Essential,1IQ5,CALM1,CALM1,BC047523,Chromosome:14,14q24-q31 19,Mitogen-activated protein kinase 9,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P45984,"JNK2 isoforms display different binding patterns:alpha- 1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it","",">Mitogen-activated protein kinase 9 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRA YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIK HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWS VGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIF PSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIE EWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL EGCR",MAPK9,Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2; JNK-55,424,48140,5.34,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6886,"",,"","",None,None,Non Essential,"",MAPK9,MAPK9,BC032539,"","" 20,Glutamate [NMDA] receptor subunit 3A,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,Q8TCU5,"NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity)","",">Glutamate [NMDA] receptor subunit 3A MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAPD DSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEG LLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELD LVSLVLHIPVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFL LLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPP ELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCM EVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIV MDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSS LHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVT SFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSP FGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVG EKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLD AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRV VPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLH RAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFSDEEGQNQLGIRIHQDIPLPP RRRELPALRTTNGKADSLNVSRNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES",GRIN3A,N-methyl-D-aspartate receptor subtype NR3A; NMDAR-L,1115,125467,7.62,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00060:Lig_chan,HGNC:16767,Cell membrane,,"","",1-23,"675-695 749-769 931-951",Non Essential,"",GRIN3A,GRIN3A,AL356516,"","" 21,Cytochrome c oxidase subunit 3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P00414,"Subunits I, II and III form the functional core of the enzyme complex","",">Cytochrome c oxidase subunit 3 MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTRESTYQGH HTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLAS GVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVII GSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS",MT-CO3,Cytochrome c oxidase polypeptide III,261,29951,7.34,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane",Energy production and conversion,PF00510:COX3,HGNC:7422,Mitochondrion inner membrane,,"","",None,"15-35 42-59 81-101 127-147 159-179 197-217 239-259",Non Essential,"",MT-CO3,MT-CO3,AF004341,"Chromosome:MT   
HGNC chromosome: mitochondria","" 22,Parathyroid hormone-related protein,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P12272,Osteostatin is a potent inhibitor of osteoclastic bone resorption,"",">Parathyroid hormone-related protein MQRRLVQQWSVAVFLLSYAVPSCGRSVEGLSRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTA EIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKK RRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH",PTHLH,PTH-rP; PTHrP; Contains: RecName: PTHrP[1-36]; Contains: RecName: PTHrP[38-94]; Contains: RecName: Osteostatin; PTHrP[107-139],177,20194,10.90,">>> Function: signal transducer activity Function: receptor binding Function: hormone activity || >>> Process: physiological process Process: organismal physiological process Process: reproductive organismal physiological process Process: lactation || >>> Component: extracellular region","",PF01279:Parathyroid,HGNC:9607,Cytoplasm. Nucleus. Secreted,,"","",1-24,None,Non Essential,1BZG,PTHLH,PTHLH,M34071,Chromosome:12,12p12.1-p11.2 23,Tubulin gamma-1 chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P23258,"Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly","",">Tubulin gamma-1 chain MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLE PRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHS IAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTAL NRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQ SVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIP WGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDE MDTSREIVQQLIDEYHAATRPDYISWGTQEQ",TUBG1,Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1,451,51171,6.06,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12417,Centrosome,,"","",None,None,Non Essential,"",TUBG1,TUBG1,BC000619,Chromosome:17,17q21 24,Alcohol dehydrogenase 1B,2009-04-08 04:35:11 UTC,2009-06-30 03:51:34 UTC,P00325,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase 1B MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEA AGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHH FLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVM GCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASL LCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHV LPFEKINEGFDLLHSGKSIRTVLTF",ADH1B,Alcohol dehydrogenase subunit beta,375,39855,8.38,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:250,Cytoplasm,,"","",None,None,Non Essential,1HSZ,ADH1B,ADH1B,AF040967,"","" 25,Alcohol dehydrogenase 1C,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P00326,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase 1C MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEA AGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHH FVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVM GCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASL LCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNI LPFEKINEGFDLLRSGKSIRTVLTF",ADH1C,Alcohol dehydrogenase subunit gamma,375,39868,8.38,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:251,Cytoplasm,,"","",None,None,Non Essential,1HT0,ADH1C,ADH1C,BC074786,"","" 26,Sodium/potassium-transporting ATPase alpha-1 chain,2009-04-08 04:35:11 UTC,2009-07-22 22:36:32 UTC,P05023,"This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients","",">Sodium/potassium-transporting ATPase subunit alpha-1 MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAE ILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVV IITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANG CKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGG QTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKR MARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLA LSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQL SIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFL PDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKG VGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLI IVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD NLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPK TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQ RKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRM YPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY",ATP1A1,Sodium pump subunit alpha-1; Na(+)/K(+) ATPase alpha-1 subunit,1023,112897,5.15,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: monovalent inorganic cation transporter activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: monovalent inorganic cation transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:799,Membrane,,"","",None,"88-108 132-152 289-308 321-338 773-792 803-823 844-866 919-938 952-970 986-1006",Non Essential,1MO8,ATP1A1,ATP1A1,M16794,"","" 27,Ig kappa chain V-III region SIE,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P01620,"","",">Ig kappa chain V-III region SIE EIVLTQSPGTLSLSPGERATLSCRASQSVSNSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGT DFTLTISRLEPDDFAVYYCQQYGSSPQTFGQGSKVEIKR","","",109,11775,8.68,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,1QLR,"","","","","" 28,Hypoxanthine-guanine phosphoribosyltransferase,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P00492,IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate,"",">Hypoxanthine-guanine phosphoribosyltransferase MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKG GYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTG KTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISE TGKAKYKA",HPRT1,HGPRTase; HGPRT,218,24580,6.67,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring glycosyl groups Function: transferase activity, transferring pentosyl groups Function: hypoxanthine phosphoribosyltransferase activity || >>> Process: nucleoside metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: purine salvage Process: purine ribonucleoside salvage || >>> Component: cell Component: intracellular Component: cytoplasm",Nucleotide transport and metabolism,PF00156:Pribosyltran,HGNC:5157,Cytoplasm,,"","",None,None,Non Essential,1BZY,HPRT1,HPRT1,S60300,"","" 29,Plasma membrane calcium-transporting ATPase 4,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P23634,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell,"",">Plasma membrane calcium-transporting ATPase 4 MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKTSPVEGLSGNP ADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPE DENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGD IAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQT GIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKS VLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVA VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQI PSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEE KLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTVIEPM ACDGLRTICIAYRDFDDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNI NTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIID STVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSI SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKP LISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRK IHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIP TRSLKFLKEAGHGTTKEEITKDAEGLDEIDHAEMELRRGQILWFRGLNRIQTQIDVINTFQTGASFKGVL RRQNMGQHLDVKLVPSSSYIKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEE NPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV",ATP2B4,PMCA4; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4; Matrix-remodeling-associated protein 1,1241,137922,6.56,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:817,Cell membrane,,"","",None,"93-113 151-171 357-376 410-427 841-860 871-891 912-934 953-974 994-1015 1026-1047",Non Essential,"",ATP2B4,ATP2B4,U42378,"","" 30,Mitogen-activated protein kinase 6,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,Q16659,Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity),"",">Mitogen-activated protein kinase 6 MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIR RLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGL KYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYT KAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQ LLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSH IYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYS TEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKK GKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQL ELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLD KFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPS AMKSSPQIPHQTYSSILKHLN",MAPK6,Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK,721,82682,4.67,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6879,"",,"","",None,None,Non Essential,"",MAPK6,MAPK6,BC035492,Chromosome:15,15q21 31,Gamma-aminobutyric acid receptor subunit gamma-2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P18507,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit gamma-2 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVIL NNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSN MVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSS YGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTY IPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSAL VEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCC FEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL",GABRG2,GABA(A) receptor subunit gamma-2,467,54163,8.60,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4087,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-39,"274-296 300-322 334-356 444-466",Non Essential,"",GABRG2,GABRG2,BC074795,"","" 32,Ig heavy chain V-III region LAY,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P01775,"","",">Ig heavy chain V-III region LAY AVQLLESGGGLVQPGGSLRLSCAASGFTFSASAMSWVRQAPGKGLEWVAWKYENGNDKHYADSVNGRFTI SRNDSKNTLYLQMNGLQAZVSAIYYCARDAGPYVSPTFFAHWGQGTLVT","","",119,12857,8.69,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 33,Hemoglobin subunit epsilon,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P02100,The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin,"",">Hemoglobin subunit epsilon MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFDSFGNLSSPSAILGNPKVKAHGKKVLT SFGDAIKNMDNLKPAFAKLSELHCDKLHVDPENFKLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAI ALAHKYH",HBE1,Hemoglobin epsilon chain; Epsilon-globin,147,16203,9.10,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4830,"",,"","",None,None,Non Essential,1A9W,HBE1,HBE1,BC015537,Chromosome:11,11p15.5 34,Androgen receptor,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P10275,"Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3","",">Androgen receptor MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQ QQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAAS KGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAR EASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPT PCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGA LDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGP GSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLA GQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCL ICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARK LKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAAL LSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDR IIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGK VKPIYFHTQ",AR,Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4,919,98990,6.38,">>> Function: transcription factor activity Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: androgen receptor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF02166:Androgen_recep PF00104:Hormone_recep PF00105:zf-C4",HGNC:644,Nucleus,,"","",None,None,Non Essential,1E3G,AR,AR,U16371,"","" 35,"Cytochrome c oxidase subunit 8A, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P10176,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 8A, mitochondrial MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILSHLETYRRPE",COX8A,Cytochrome c oxidase polypeptide VIII-liver/heart; Cytochrome c oxidase subunit 8-2,69,7579,10.83,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02285:COX8,HGNC:2294,Mitochondrion inner membrane,"","","",None,37-60,Non Essential,"",COX8A,COX8A,BC063025,Chromosome:11,11q12-q13 36,Gamma-aminobutyric-acid receptor subunit alpha-1,2009-04-08 04:35:11 UTC,2009-07-22 22:35:21 UTC,P14867,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-1 MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKT DIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMT MPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAE DGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVP ARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVV PEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ",GABRA1,GABA(A) receptor subunit alpha-1,456,51802,9.61,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4075,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-27,"252-273 279-300 313-334 422-443",Non Essential,"",GABRA1,GABRA1,X14766,"","" 37,Tubulin alpha-1A chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,Q71U36,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-1A chain MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDL EPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHS FGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGVDSVEGEGEEEGEEY",TUBA1A,Tubulin B-alpha-1; Tubulin alpha-3 chain; Alpha-tubulin 3,451,50136,4.70,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20766,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA1A,TUBA1A,K00557,Chromosome:12,12q12-q14.3 38,Hemoglobin subunit gamma-1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,P69891,"Gamma chains make up the fetal hemoglobin F, in combination with alpha chains","",">Hemoglobin subunit gamma-1 MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLT SLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVAS ALSSRYH",HBG1,Hemoglobin gamma-1 chain; Gamma-1-globin; Hemoglobin gamma-A chain; Hb F Agamma,147,16141,7.23,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4831,"",,"","",None,None,Non Essential,1I3E,HBG1,HBG1,BC020719,Chromosome:11,11p15.5 39,Tubulin alpha-3E chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:35 UTC,Q6PEY2,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin alpha-3E chain MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDL EPTVVDEVRTGTYRQLFHPEQLITGKEDAASNYARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHS FGGGTGSGFASLLMERLSVDYSKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLVHKFDLMYAKWAFVHWYVGEGMEEGEFSE AREDLAALEKDCEEVGVDSVEAEAEEGEEY",TUBA3E,Alpha-tubulin 3E,450,49917,4.73,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20765,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA3E,TUBA3E,BC057811,"","" 40,Tubulin alpha-4A chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P68366,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-4A chain MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGKHVPRAVFVDL EPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLDRIRKLSDQCTGLQGFLVFHS FGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGIDSYEDEDEGEE",TUBA4A,Tubulin alpha-1 chain; Alpha-tubulin 1; Testis-specific alpha-tubulin; Tubulin H2-alpha,448,49925,4.69,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12407,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA4A,TUBA4A,BC009238,"","" 41,Alpha-synuclein,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P37840,"May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule- associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation","",">Alpha-synuclein MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAV VTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA",SNCA,Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP,140,14460,4.37,">>> Function: Not Available || >>> Process: Not Available || >>> Component: cell Component: intracellular Component: cytoplasm","",PF01387:Synuclein,HGNC:11138,Cytoplasm. Membrane. Nucleus,,"","",None,None,Non Essential,1XQ8,SNCA,SNCA,BC108275,"","" 42,ATP-citrate synthase,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P53396,ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine,"",">ATP-citrate synthase MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLG LVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGV DVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKD GVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVA GGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNV AATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALG HRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKST TLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAM RKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIK PGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDH VLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASE TAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASF MTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNT IICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSI NNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADE YIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM",ACLY,ATP-citrate (pro-S-)-lyase; Citrate cleavage enzyme,1101,120841,7.34,">>> Function: catalytic activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Energy production and conversion,"PF02629:CoA_binding PF00549:Ligase_CoA",HGNC:115,Cytoplasm,,"","",None,None,Non Essential,"",ACLY,ACLY,BC006195,Chromosome:17,17q12-q21 43,Histone H3.1t,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q16695,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H3.1t MARTKQTARKSTGGKAPRKQLATKVARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQR LMREIAQDFKTDLRFQSSAVMALQEACESYLVGLFEDTNLCVIHAKRVTIMPKDIQLARRIRGERA",HIST3H3,H3t; H3/t; H3/g,136,15509,11.71,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:4778,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST3H3,HIST3H3,BC101839,"","" 44,Cytochrome P450 1A1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P04798,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics","",">Cytochrome P450 1A1 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQY GDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQN GLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHN HQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM TPIYGLTMKHACCEHFQMQLRS",CYP1A1,CYPIA1; P450-P1; P450 form 6; P450-C,512,58166,8.47,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2595,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP1A1,CYP1A1,AF040259,Chromosome:15,15q24.1 45,Tubulin beta-2C chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P68371,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin beta-2C chain MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEP GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK TAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEEGEFEEEAEEEVA",TUBB2C,Tubulin beta-2 chain,445,49832,4.52,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20771,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB2C,TUBB2C,BC071889,"","" 46,Peroxisome proliferator-activated receptor alpha,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q07869,"Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids","",">Peroxisome proliferator-activated receptor alpha MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITD TLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCD RSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRI YEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTS VETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKP FCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY",PPARA,PPAR-alpha; Nuclear receptor subfamily 1 group C member 1,468,52226,6.20,">>> Function: steroid hormone receptor activity Function: transcription factor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:9232,Nucleus,,"","",None,None,Non Essential,1K7L,PPARA,PPARA,AL078611,Chromosome:22,22q12-q13.1|22q13.31 47,Aquaporin-12A,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q8IXF9,Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity),"",">Aquaporin-12A MAGLNVSLSFFFATFALCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLLLTLLFLLFLA HGVTLDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLCWAWELSDLHLLQSLMAQSCS SALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFA CSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSS VREPGRSGVEGPHSS",AQP12A,AQP-12,295,31475,8.30,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane","","",HGNC:19941,Membrane,,"","",None,"1-21 55-75 100-126 146-166 179-199 216-236",Non Essential,"",AQP12A,AQP12A,AB040748,"","" 48,Cytochrome c oxidase subunit 6B2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q6YFQ2,Connects the two COX monomers into the physiological dimeric form (By similarity),"",">Cytochrome c oxidase subunit VIb isoform 2 MLDVEAQEPPKGKWSTPPFDPRFPSQNQIRNCYQNFLDYHRCLKTRTRRGKSTQPCEYYFRVYHSLCPIS WVESWNEQIKNGIFAGKI",COX6B2,"COX VIb-2; Cytochrome c oxidase subunit VIb, testis-specific isoform; Cancer/testis antigen 59; CT59",88,10529,9.25,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: mitochondrion","",PF02297:COX6B,HGNC:24380,Mitochondrion intermembrane space (By similarity),"","","",None,None,Non Essential,"",COX6B2,COX6B2,BC100902,Chromosome:19,19q13.42 49,Cytochrome c oxidase subunit 6C,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P09669,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide VIc MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGI FQSVK",COX6C,"",75,8782,10.98,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02937:COX6C,HGNC:2285,Mitochondrion inner membrane,"","","",None,14-54,Non Essential,"",COX6C,COX6C,BC000187,"","" 50,Alcohol dehydrogenase class-3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P11766,"Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione","",">Alcohol dehydrogenase class-3 MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGA GIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHY MGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGGVGLAVIMG CKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALE ACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNL SFDEINKAFELMHSGKSIRTVVKI",ADH5,Alcohol dehydrogenase class-III; Alcohol dehydrogenase 5; Alcohol dehydrogenase class chi chain; S-(hydroxymethyl)glutathione dehydrogenase; Glutathione-dependent formaldehyde dehydrogenase; GSH-FDH; FALDH; FDH,374,39725,7.54,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:253,Cytoplasm,,"","",None,None,Non Essential,1MC5,ADH5,ADH5,BC014665,"","" 51,Progesterone receptor,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P06401,The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues,"",">Progesterone receptor MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPS DEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSW CLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPV KPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRV ALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASS TPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLL PRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFE SLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQA GMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIY AGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKH VSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMS EVIAAQLPKILAGMVKPLLFHKK",PGR,PR; Nuclear receptor subfamily 3 group C member 3,933,98982,6.45,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF02161:Prog_receptor PF00105:zf-C4",HGNC:8910,Nucleus,,"","",None,None,Non Essential,1SQN,PGR,PGR,AY525610,Chromosome:11,11q22-q23 52,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q15119,"Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism","",">[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINL LPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDT YGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKL LCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALG EEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSME GFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS",PDK2,Pyruvate dehydrogenase kinase isoform 2,407,46154,6.59,">>> Function: kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: physiological process Process: metabolism Process: cellular metabolism Process: phosphorus metabolism Process: phosphate metabolism Process: phosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF02518:HATPase_c,HGNC:8810,Mitochondrion matrix,,"","",None,None,Non Essential,1JM6,PDK2,PDK2,BC040478,Chromosome:17,17q21.33 53,Gamma-aminobutyric acid receptor subunit rho-2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P28476,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission","",">Gamma-aminobutyric acid receptor subunit rho-2 MPYFTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLRVDEHDFSMRP AFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRLVKKIWVPDVFF VHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYW KNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW VSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTT VQERKERKLREKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAA RKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVFS",GABRR2,GABA(A) receptor subunit rho-2,465,54152,9.58,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4091,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-20,"262-285 289-311 323-345 444-465",Non Essential,"",GABRR2,GABRR2,BC130354,"","" 54,Protein kinase C gamma type,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P05129,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters","",">Protein kinase C gamma type MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCS FVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHR RCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQ KTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQ EEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISD FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDA EGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDE EELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPP FRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM",PRKCG,PKC-gamma,697,78449,7.49,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9402,"",,"","",None,None,Non Essential,"",PRKCG,PRKCG,Z15114,Chromosome:19,19q13.4 55,Aquaporin-4,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P55087,Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system,"",">Aquaporin-4 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDM VLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPS VVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGA SMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEV EDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSV",AQP4,AQP-4; WCH4; Mercurial-insensitive water channel; MIWC,323,34830,7.75,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:637,Membrane,,"","",None,"37-57 65-85 116-136 156-176 185-205 232-252",Non Essential,"",AQP4,AQP4,BC022286,Chromosome:18,18q11.2-q12.1 56,DNA topoisomerase 2-beta,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q02880,Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks,"",">DNA topoisomerase 2-beta MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDT YIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIW NNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHS FKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNG KKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYV VDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLA VSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIM TDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHG LPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAG SVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPML PNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKE YHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSY YGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAE EDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLA AFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK KKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVK KRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKAS PITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEED SASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGK GRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYF AESDEEEDDVDFAMFN",TOP2B,"DNA topoisomerase II, beta isozyme",1626,183269,8.16,">>> Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: DNA topoisomerase activity Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: nucleic acid binding Function: DNA binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: DNA topological change Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism || >>> Component: Not Available","Replication, recombination and repair","PF00204:DNA_gyraseB PF00521:DNA_topoisoIV PF08070:DTHCT PF02518:HATPase_c",HGNC:11990,"Cytoplasm. Nucleus, nucleolus",,"","",None,None,Non Essential,"",TOP2B,TOP2B,U54831,"","" 57,"Cytochrome c oxidase subunit 4 isoform 2, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q96KJ9,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase subunit 4 isoform 2, mitochondrial MLPRAAWSLVLRKGGGGRRGMHSSEGTTRGGGKMSPYTNCYAQRYYPMPEEPFCTELNAEEQALKEKEKG SWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVIWWQRVYVFPPKPITLTDERK AQQLQRMLDMKVNPVQGLASRWDYEKKQWKK",COX4I2,Cytochrome c oxidase subunit IV isoform 2; COX IV-2,171,20010,10.13,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02936:COX4,HGNC:16232,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",COX4I2,COX4I2,BC057779,Chromosome:20,20q11.21 58,DNA repair protein XRCC1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P18887,Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents,"",">DNA repair protein XRCC1 MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEV LVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDS PFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPGALFFSRINKTSPVTASDPAGPS YAAATLQASSAASSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTR TPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYR PDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSRRYLMAGPGSSSEEDEASHSGG SGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKAASPVLQEDIDIEGVQSEGQDNGAEDSGDTED ELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERR KLIRYVTAFNGELEDYMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPHQLYGVV PQA",XRCC1,X-ray repair cross-complementing protein 1,633,69526,6.33,">>> Function: binding Function: nucleic acid binding Function: DNA binding Function: damaged DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA repair Process: single strand break repair || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: cell Component: intracellular","","PF00533:BRCT PF01834:XRCC1_N",HGNC:12828,Nucleus,,"","",None,None,Non Essential,1XNT,XRCC1,XRCC1,AC018758,Chromosome:19,19q13.2 59,Plasma membrane calcium-transporting ATPase 1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P20020,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell,"",">Plasma membrane calcium-transporting ATPase 1 MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEG LSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEV SVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADI TVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGV NSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKK KANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFF IIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQA YINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGLLLDLKRDY QDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRD DIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRA GITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSP TDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVK AVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTES LLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFV LMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMG TLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQMDV VNAFQSGSSIQGALRRQPSIASQHHDVTNISTPTHIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRI EDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL",ATP2B1,PMCA1; Plasma membrane calcium pump isoform 1; Plasma membrane calcium ATPase isoform 1,1258,138757,5.88,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:814,Cell membrane,,"","",None,"98-118 155-175 367-386 420-437 853-872 883-903 924-946 965-986 1006-1027 1038-1059",Non Essential,"",ATP2B1,ATP2B1,U15687,Chromosome:12,12q21.3 60,"Cytochrome c oxidase polypeptide 7A2, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,P14406,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 7A2, mitochondrial MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMILTVGGTAYAI YELAVASFPKKQE",COX7A2,Cytochrome c oxidase polypeptide VIIa-liver/heart; Cytochrome c oxidase subunit VIIa-L; VIIaL,83,9396,10.27,">>> Function: transporter activity Function: electron transporter activity Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02238:COX7a,HGNC:2288,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",COX7A2,COX7A2,BC101828,"","" 61,Protein kinase C epsilon type,2009-04-08 04:35:11 UTC,2009-06-30 03:51:36 UTC,Q02156,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters","",">Protein kinase C epsilon type MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFV TDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPK DNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHK RCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNV HRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTS PCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVN GGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILN GVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWL SKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQ DFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP",PRKCE,nPKC-epsilon,737,83675,7.13,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9401,"",,"","",None,None,Non Essential,"",PRKCE,PRKCE,BC109034,"","" 62,C-jun-amino-terminal kinase-interacting protein 4,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,O60271,The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction,"",">C-jun-amino-terminal kinase-interacting protein 4 MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQE HQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYAD QISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLP AGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPAST ANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPE LDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDD DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLF SSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYR QVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKT RDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKV LIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQ TGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGC LYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSI RCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTY QHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVI RVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGNE",SPAG9,JNK-interacting protein 4; JIP-4; JNK-associated leucine-zipper protein; JLP; Sperm-associated antigen 9; Mitogen-activated protein kinase 8-interacting protein 4; Human lung cancer protein 6; HLC-6; Proliferation-inducing protein 6; Sperm-specific protein; Sperm surface protein; Protein highly expressed in testis; PHET; Sunday driver 1; Cancer/testis antigen 89; CT89,1321,146207,4.79,"",Transcription,"",HGNC:14524,Isoform 5:Acrosome,,"","",None,None,Non Essential,"",SPAG9,SPAG9,AY219898,Chromosome:17,17q21.33 63,Alcohol dehydrogenase 1A,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P07327,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase 1A MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVTPLPVILGHEA AGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTLQDGTSRFTCRRKPIHH FLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAIM GCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASL LCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHV LPFEKINEGFDLLHSGKSIRTILMF",ADH1A,Alcohol dehydrogenase subunit alpha,375,39859,8.02,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:249,Cytoplasm,,"","",None,None,Non Essential,1HSO,ADH1A,ADH1A,M37066,"","" 64,C-jun-amino-terminal kinase-interacting protein 1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,Q9UQF2,"The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response","",">C-jun-amino-terminal kinase-interacting protein 1 MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRP PRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQ GQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEH ICLSDELPPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEE IYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGG GWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVS SPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIINGEEQE QTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKN SDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEA KGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVE YTCPTEDIYLE",MAPK8IP1,JNK-interacting protein 1; JIP-1; JNK MAP kinase scaffold protein 1; Islet-brain 1; IB-1; Mitogen-activated protein kinase 8-interacting protein 1,711,77525,4.61,"","","PF00640:PID PF00018:SH3_1",HGNC:6882,"Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity)",,"","",None,None,Non Essential,"",MAPK8IP1,MAPK8IP1,AF007134,Chromosome:11,11p12-p11.2 65,Gamma-aminobutyric acid receptor subunit gamma-1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,Q8N1C3,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit gamma-1 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNS LLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMV GKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYG YPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIP CILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALME YGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL",GABRG1,GABA(A) receptor subunit gamma-1,465,53596,8.23,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4086,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-35,"273-294 299-320 332-354 445-465",Non Essential,"",GABRG1,GABRG1,BC031087,"","" 66,Glutathione peroxidase 2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P18283,"Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors","",">Glutathione peroxidase 2 MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQ FGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLI IWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI",GPX2,GSHPx-2; GPx-2; Glutathione peroxidase-gastrointestinal; GSHPx-GI; Glutathione peroxidase-related protein 2; Gastrointestinal glutathione peroxidase; GPRP,190,21954,7.93,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4554,Cytoplasm,,"","",None,None,Non Essential,"",GPX2,GPX2,BC067221,Chromosome:14,14q24.1 67,Estrogen-related receptor gamma,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P62508,Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity),"",">Estrogen-related receptor gamma MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSS TMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHY GVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKY KRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVII GWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL QLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMT LPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV",ESRRG,Estrogen receptor-related protein 3; ERR gamma-2; Nuclear receptor subfamily 3 group B member 3,458,51307,6.44,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:3474,Nucleus (Probable),,"","",None,None,Non Essential,1VJB,ESRRG,ESRRG,AF117255,"","" 68,Potassium voltage-gated channel subfamily H member 7,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,Q9NS40,Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly,"",">Potassium voltage-gated channel subfamily H member 7 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLH GPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFEYVTDNENAAT PERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDPDVVVIDSSKHSDDSVAMKHFKSPTKESCSP SEADDTKALIQPSKCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIE GFGVHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSS PPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIY TAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAI HYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLSMCIFA LNAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGF GNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRL EEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHALQGD TLVHCGDVLTALYFLSRGSIEISKNDMVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQRED LLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDP EDSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKASGLDFEETVPTSGRMHID KRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESDLTYGEVEQRLDLLQEQLNRLESQMT TDIQTILQLLQKQTTVVPPAYSMVTAGSEYQRPIIQLMRTSQPEASIKTDRSFSPSSQCPEFLDLEKSKL KSKESLSSGVHLNTASEDNLTSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGLHRHVSD PGLPGK",KCNH7,Voltage-gated potassium channel subunit Kv11.3; Ether-a-go-go-related gene potassium channel 3; HERG-3; Ether-a-go-go-related protein 3; Eag-related protein 3,1196,135014,7.77,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans",HGNC:18863,Membrane,,"","",None,"413-433 450-470 495-515 522-542 550-570 642-662",Non Essential,"",KCNH7,KCNH7,AF032897,"","" 69,Cytochrome c oxidase subunit 6B1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P14854,Connects the two COX monomers into the physiological dimeric form (By similarity),"",">Cytochrome c oxidase subunit VIb isoform 1 MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRVYQSLCPTSWV TDWDEQRAEGTFPGKI",COX6B1,COX VIb-1,86,10192,7.13,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: mitochondrion","",PF02297:COX6B,HGNC:2280,Mitochondrion intermembrane space (By similarity),"","","",None,None,Non Essential,1V55,COX6B1,COX6B1,X58139,Chromosome:19,19q13.1 70,Cytochrome c oxidase subunit 2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P00403,Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1,"",">Cytochrome c oxidase subunit 2 MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPA IILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDN RVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIV LELIPLKIFEMGPVFTL",MT-CO2,Cytochrome c oxidase polypeptide II,227,25565,4.44,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: copper ion binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: organelle membrane Component: organelle inner membrane Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Energy production and conversion,"PF00116:COX2 PF02790:COX2_TM",HGNC:7421,Mitochondrion inner membrane,,"","",None,"27-48 63-82",Non Essential,"",MT-CO2,MT-CO2,X55654,"Chromosome:MT   
HGNC chromosome: mitochondria","" 71,Glutathione peroxidase 6,2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,P59796,2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O,"",">Glutathione peroxidase 6 MFQQFQASCLVLFFLVGFAQQTLKPQNRKVDCNKGVTGTIYEYGALTLNGEEYIQFKQFAGKHVLFVNVA AYUGLAAQYPELNALQEELKNFGVIVLAFPCNQFGKQEPGTNSEILLGLKYVCPGSGFVPSFQLFEKGDV NGEKEQKVFTFLKNSCPPTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMHWFHQAPVSTVKSD ILEYLKQFNTH",GPX6,"",221,24971,6.66,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4558,Secreted (By similarity),,"","",1-19,None,Non Essential,"",GPX6,GPX6,DQ088982,"","" 72,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:37 UTC,Q15118,"Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism","",">[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNA CEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTD TVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSP SHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFEL FKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAV PLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDW CVPSREPKDMTTFRSA",PDK1,Pyruvate dehydrogenase kinase isoform 1,436,49245,9.05,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF02518:HATPase_c,HGNC:8809,Mitochondrion matrix,,"","",None,None,Non Essential,"",PDK1,PDK1,BC039158,"","" 73,Protein kinase C beta type,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P05771,"This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking (By similarity)","",">Protein kinase C beta type MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVC CFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVH KRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQ KTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQ EEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGK GSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE NIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF DKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEFVINV",PRKCB,PKC-beta; PKC-B,671,76870,7.00,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9395,Cytoplasm (By similarity). Membrane,,REACT_604-Hemostasis;,"",None,None,Non Essential,"",PRKCB,PRKCB,X05971,Chromosome:16,16p11.2 74,Tubulin beta-6 chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q9BUF5,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-6 chain MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEP GTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVVRKECEHCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDARNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQSKNSSYFVEWIPNNVK VAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVS EYQQYQDATANDGEEAFEDEEEEIDG",TUBB6,"",446,49858,4.51,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20776,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB6,TUBB6,BC002654,Chromosome:18,18p11.21 75,Mitogen-activated protein kinase 13,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,O15264,Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K,"",">Mitogen-activated protein kinase 13 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVG CIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQ AADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFS PIARKDSRRRSGMKL",MAPK13,Stress-activated protein kinase 4; Mitogen-activated protein kinase p38 delta; MAP kinase p38 delta,365,42090,8.66,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6875,"",,"","",None,None,Non Essential,"",MAPK13,MAPK13,BC004428,"","" 76,Histone H3.3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P84243,"Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H3.3 MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQR LVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA",H3F3A,"",136,15328,11.83,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:4764,Nucleus,,"","",None,None,Non Essential,1EQZ,H3F3A,H3F3A,BC108701,"","" 77,Hemoglobin subunit mu,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q6B0K9,"","",">Hemoglobin subunit mu MLSAQERAQIAQVWDLIAGHEAQFGAELLLRLFTVYPSTKVYFPHLSACQDATQLLSHGQRMLAAVGAAV QHVDNLRAALSPLADLHALVLRVDPANFPLLIQCFHVVLASHLQDEFTVQMQAAWDKFLTGVAVVLTEKY R",HBM,Hemoglobin mu chain; Mu-globin,141,15618,6.62,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4826,"",,"","",None,None,Non Essential,"",HBM,HBM,BC035682,Chromosome:16,16p13.3 78,Hemoglobin subunit delta,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P02042,Involved in oxygen transport from the lung to the various peripheral tissues,"",">Hemoglobin subunit delta MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFESFGDLSSPDAVMGNPKVKAHGKKVLG AFSDGLAHLDNLKGTFSQLSELHCDKLHVDPENFRLLGNVLVCVLARNFGKEFTPQMQAAYQKVVAGVAN ALAHKYH",HBD,Hemoglobin delta chain; Delta-globin,147,16056,8.26,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4829,"",,"","",None,None,Non Essential,1SI4,HBD,HBD,BC070282,Chromosome:11,11p15.5 79,Aquaporin-6,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q13520,"Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism (By similarity)","",">Aquaporin-6 MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAV QVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINVVRNSVS TGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKF TVHWVFWVGPLMGALLASLIYNFVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEME SV",AQP6,AQP-6; Aquaporin-2-like; Kidney-specific aquaporin; hKID,282,29371,8.86,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:639,Cytoplasmic vesicle membrane,,"","",None,"31-48 55-73 100-121 142-162 169-188 215-236",Non Essential,"",AQP6,AQP6,U48408,Chromosome:12,12q13 80,Porphobilinogen deaminase,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P08397,Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps,"",">Porphobilinogen deaminase MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSK IGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEK SVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGWHNRVGQILHPEE CMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTG GVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNI LDVARQLNDAH",HMBS,PBG-D; Pre-uroporphyrinogen synthase; Hydroxymethylbilane synthase; HMBS,361,39331,7.19,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring alkyl or aryl (other than methyl) groups Function: hydroxymethylbilane synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,"PF01379:Porphobil_deam PF03900:Porphobil_deamC",HGNC:4982,Cytoplasm (Probable),,"","",None,None,Non Essential,"",HMBS,HMBS,S60381,Chromosome:11,11q23.3 81,"Cytochrome c oxidase subunit 7B2, mitochondrial ",2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q8TF08,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 7B2, mitochondrial MFPLARNALSSLKIQSILQSMARHSHVKHSPDFHDKYGNAVLASGTAFCVATWVFTATQIGIEWNLSPVG RVTPKEWKHQ",COX7B2,Cytochrome c oxidase polypeptide VIIb2,80,8946,10.37,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane Component: organelle membrane Component: organelle inner membrane Component: mitochondrial inner membrane Component: mitochondrial electron transport chain","",PF05392:COX7B,HGNC:24381,Mitochondrion inner membrane (By similarity),"","","",None,33-59,Non Essential,"",COX7B2,COX7B2,BC107855,"","" 82,Mitogen-activated protein kinase 11,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q15759,"Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2","",">Mitogen-activated protein kinase 11 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKY IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVG CIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPL AIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKP PEPPKPPGSLEIEQ",MAPK11,Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; p38-2; Stress-activated protein kinase 2,364,41358,5.64,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","","",HGNC:6873,"",,"","",None,None,Non Essential,"",MAPK11,MAPK11,BC027933,Chromosome:22,22q13.33 83,Uteroglobin,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P11684,"Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2","",">Uteroglobin MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLP QKPRESIIKLMEKIAQSSLCN",SCGB1A1,Secretoglobin family 1A member 1; Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; Urinary protein 1; Urine protein 1; UP1,91,9994,4.71,">>> Function: binding Function: steroid binding || >>> Process: Not Available || >>> Component: Not Available","",PF01099:Uteroglobin,HGNC:12523,Secreted,,"","",1-21,None,Non Essential,"",SCGB1A1,SCGB1A1,X59875,Chromosome:11,11q12.3-q13.1 84,Plasma membrane calcium-transporting ATPase 3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,Q16720,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell,"",">Plasma membrane calcium-transporting ATPase 3 MGDMANSSIEFHPKPQQQRDVPQAGGFGCTLAELRTLMELRGAEALQKIEEAYGDVSGLCRRLKTSPTEG LADNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNV SGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAA LVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVG VNSQTGIIFTLLGAGGEEEEKKDKKGKQQDGAMESSQTKAKKQDGAVAMEMQPLKSAEGGEMEEREKKKA NAPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVEGRTWLAECTPVYVQYFVKFFII GVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYL GDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFVLDLKRDFQP VREQIPEDKLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDM VRKIIEPMACDGLRTICIAYRDFSAGQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGIT VRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDK HTLVKGIIDSTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVM WGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLL RKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNTFVMMQ LFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELV WGQVIATIPTSQLKCLKEAGHGPGKDEMTDEELAEGEEEIDHAERELRRGQILWFRGLNRIQTQIRVVKA FRSSLYEGLEKPESKTSIHNFMATPEFLINDYTHNIPLIDDTDVDENEERLRAPPPPSPNQNNNAIDSGI YLTTHVTKSATSSVFSSSPGSPLHSVETSL",ATP2B3,PMCA3; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium pump isoform 3,1220,134199,5.29,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:816,Cell membrane,,"","",None,"98-118 156-176 365-384 418-435 850-869 880-900 921-943 962-983 1003-1024 1035-1056",Non Essential,"",ATP2B3,ATP2B3,U15690,"","" 85,Ig kappa chain C region,2009-04-08 04:35:11 UTC,2009-06-30 03:51:38 UTC,P01834,"","",">Ig kappa chain C region TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC",IGKC,"",106,11609,5.68,"","",PF07654:C1-set,HGNC:5716,"",,"","",None,None,Non Essential,1N8Z,IGKC,IGKC,J00241,"","" 86,Thioredoxin reductase 3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,Q86VQ6,"Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)","",">Thioredoxin reductase 3 MGHVHRLVSGKRRMHLTSRPVASTHSPLILDMCPHLNNGPMTGCGRAGDPISHARGGAGGRGERLPRGFA RVVRVASEGSVRRPSGPVPAPQPPAFRFVSRPGRARSESETLERSPPQSPGPGKAGDAPNRRSGHVRGAR VLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELD QVDDGARVQEVLSEITNQKTVPNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGL SCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVR HNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERP RYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEK VGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKIGLEKI GVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVF TPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNA GEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG",TXNRD3,Thioredoxin reductase TR2; Thioredoxin and glutathione reductase,754,82465,8.80,">>> Function: oxidoreductase activity, acting on NADH or NADPH Function: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor Function: disulfide oxidoreductase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: catalytic activity Function: oxidoreductase activity Function: transporter activity Function: electron transporter activity || >>> Process: homeostasis Process: cell homeostasis Process: cell redox homeostasis Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: intracellular Component: cytoplasm",Energy production and conversion,"PF00462:Glutaredoxin PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim",HGNC:20667,Cytoplasm (By similarity). Nucleus (By similarity). Microsome (By similarity). Endoplasmic reticulum (By similarity),,"","",None,None,Non Essential,"",TXNRD3,TXNRD3,AF133519,"","" 87,Alcohol dehydrogenase 6,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P28332,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase 6 MSTTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKVLGSKHLDLLYPTILGHE GAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQSKTQLMSDGTSRFTCKGKSIYH FGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFSTGFGAAINTAKVTPGSTCAVFGLGGVGLSVVM GCKAAGAARIIGVDVNKEKFKKAQELGATECLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDVLAAAL ASCNESYGVCVVVGVLPASVQLKISGQLFFSGRSLKGSVFGGWKSRQHIPKLVADYMAEKLNLDPLITHT LNLDKINEAVELMKTGKW",ADH6,"",368,39073,7.86,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:255,Cytoplasm,,"","",None,None,Non Essential,"",ADH6,ADH6,AY962311,"","" 88,"Cytochrome c oxidase subunit 6A2, mitochondrial ",2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,Q02221,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 6A2, mitochondrial MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLHSGHRPRPEFRPYQHLRIRTK PYPWGDGNHTLFHNSHVNPLPTGYEHP",COX6A2,Cytochrome c oxidase polypeptide VIa-heart; COXVIAH,97,10816,11.37,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: envelope Component: organelle envelope Component: mitochondrial envelope","",PF02046:COX6A,HGNC:2279,Mitochondrion inner membrane,"","","",None,None,Non Essential,"",COX6A2,COX6A2,BC029818,Chromosome:16,16p 89,Aquaporin-11,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,Q8NBQ7,Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity),"",">Aquaporin-11 MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVAHAFVLEFLATFQLCCCTHELQLLSEQ HPAHPTWTLTLVYFFSLVHGLTLVGTSSNPCGVMMQMMLGGMSPETGAVRLLAQLVSALCSRYCTSALWS LGLTQYHVSERSFACKNPIRVDLLKAVITEAVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVYAGGSL TGAVFNPALALSLHFMCFDEAFPQFFIVYWLAPSLGILLMILMFSFFLPWLHNNHTINKKE",AQP11,AQP-11,271,30203,7.95,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane","","",HGNC:19940,Membrane,,"","",None,"15-35 42-62 75-95 164-184 195-215 235-255",Non Essential,"",AQP11,AQP11,BC040443,Chromosome:11,11q14.1 90,Sodium/potassium-transporting ATPase subunit beta-1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P05026,"This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane","",">Sodium/potassium-transporting ATPase subunit beta-1 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQD RVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFN HERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLP VQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYG ENIGYSEKDRFQGRFDVKIEVKS",ATP1B1,Sodium/potassium-dependent ATPase subunit beta-1,303,35062,8.73,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: sodium:potassium-exchanging ATPase activity || >>> Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF00287:Na_K-ATPase,HGNC:804,Membrane,,"","",None,35-62,Non Essential,"",ATP1B1,ATP1B1,X17161,"","" 91,"5-aminolevulinate synthase, erythroid-specific, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P22557,Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2),"",">5-aminolevulinate synthase, erythroid-specific, mitochondrial MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGGDSPSWAKGHC PFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQEQEQISGKVTHLIQNNMPGN YVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQ ATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYS DAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQY GALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLC DLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRR PVHFELMSEWERSYFGNMGPQYVTTYA",ALAS2,5-aminolevulinic acid synthase; Delta-aminolevulinate synthase; Delta-ALA synthetase; ALAS-E,587,64634,8.19,">>> Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity Function: N-acyltransferase activity Function: N-succinyltransferase activity Function: 5-aminolevulinate synthase activity || >>> Process: biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis Process: heme biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,"PF00155:Aminotran_1_2 PF09029:Preseq_ALAS",HGNC:397,Mitochondrion matrix,,"","",None,None,Non Essential,"",ALAS2,ALAS2,AL020991,"","" 92,Histone H4,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P62805,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H4 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDA VTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG",HIST1H4A,"",103,11368,11.91,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:4781,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H4A,HIST1H4A,BC143045,"","" 93,Tubulin beta-1 chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,Q9H4B7,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-1 chain MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEP GTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLG GGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDI CFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQ YRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVK VAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVS EYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH",TUBB1,"",451,50328,4.82,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:16257,Cytoplasmic,,"","",None,None,Non Essential,"",TUBB1,TUBB1,BC033679,Chromosome:20,20q13.32 94,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,Q9Y3Q4,Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli,"",">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSS ALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPG EDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQ AGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIII PVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSI PVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMS DVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ GKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGK KMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMR RAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPT PVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSA SPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHF HKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPG ELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHG SLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFP RAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGA RPEPVRSKLPSNL",HCN4,"",1203,129043,9.15,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08412:Ion_trans_N",HGNC:16882,Membrane,,"","",None,"267-287 294-314 341-361 369-389 421-441 465-486 497-517",Non Essential,1Q3E,HCN4,HCN4,AJ238850,Chromosome:15,15q24-q25 95,DNA polymerase subunit gamma-1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P54098,Involved in the replication of mitochondrial DNA,"",">DNA polymerase subunit gamma-1 MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLR HNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFR LLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPT LAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIRE QYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDI SSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPH PVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEW DLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLP KRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDN LAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVE AEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDF LPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAI LPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGM HGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAE KAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQRETARKSQWKKWEVVAERAWK GGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLF EEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLR KEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP",POLG,Mitochondrial DNA polymerase catalytic subunit; PolG-alpha,1239,139564,6.89,">>> Function: gamma DNA-directed DNA polymerase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: nucleotidyltransferase activity Function: DNA-directed DNA polymerase activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA replication || >>> Component: protein complex Component: gamma DNA polymerase complex","Replication, recombination and repair",PF00476:DNA_pol_A,HGNC:9179,Mitochondrion,,"","",None,None,Non Essential,"",POLG,POLG,BC050559,Chromosome:15,15q25 96,Eosinophil peroxidase,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P11678,Donor + H(2)O(2) = oxidized donor + 2 H(2)O,"",">Eosinophil peroxidase MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPM DLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAER CSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFP NERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRD CIPFFRSAPSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLP FDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARK IMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRA SAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRIGLDLAALNM QRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVG PLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVN CSRIPRLNLSAWRGT",EPX,EPO; Contains: RecName: Eosinophil peroxidase light chain; Contains: RecName: Eosinophil peroxidase heavy chain,715,81042,10.81,">>> Function: antioxidant activity Function: peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","",PF03098:An_peroxidase,HGNC:3423,Cytoplasmic granule,,"","",1-17,None,Non Essential,"",EPX,EPX,X14346,Chromosome:17,17q23.1 97,GTPase HRas,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P01112,Ras proteins bind GDP/GTP and possess intrinsic GTPase activity,"",">GTPase HRas MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQ YMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIP YIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS",HRAS,Transforming protein p21; p21ras; H-Ras-1; c-H-ras; Ha-Ras,189,21298,4.94,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding || >>> Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade Process: small GTPase mediated signal transduction || >>> Component: Not Available","",PF00071:Ras,HGNC:5173,Cell membrane,,"","",None,None,Non Essential,4Q21,HRAS,HRAS,M17232,Chromosome:11,11p15.5 98,Mitogen-activated protein kinase 3,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P27361,"Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4)","",">Mitogen-activated protein kinase 3 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAI KKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSN DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY LQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAM ELDDLPKERLKELIFQETARFQPGVLEAP",MAPK3,Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule-associated protein 2 kinase,379,43136,6.74,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6877,"",,REACT_1788-Transcription;,"",None,None,Non Essential,"",MAPK3,MAPK3,Z11696,Chromosome:16,16p11.2 99,Hemoglobin subunit gamma-2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:39 UTC,P69892,"Gamma chains make up the fetal hemoglobin F, in combination with alpha chains","",">Hemoglobin subunit gamma-2 MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLT SLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTGVAS ALSSRYH",HBG2,Hemoglobin gamma-2 chain; Gamma-2-globin; Hemoglobin gamma-G chain; Hb F Ggamma,147,16127,7.23,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4832,"",,"","",None,None,Non Essential,1FDH,HBG2,HBG2,M11427,Chromosome:11,11p15.5 100,Aquaporin-5,2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,P55064,"Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions","",">Aquaporin-5 MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINP AITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTF QLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGP IVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR",AQP5,AQP-5,265,28293,8.82,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:638,Membrane,,"","",None,"13-33 37-57 88-108 127-147 162-182 206-226",Non Essential,"",AQP5,AQP5,BC032946,Chromosome:12,12q13 101,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,Q9UL51,Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity),"",">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADEGG PRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGP AEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDF RFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPE KIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQW EEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFK AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFH KLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKL KFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRL YSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDRE MVQQAELGQRVGLFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAA SPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRP ASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL",HCN2,Brain cyclic nucleotide-gated channel 2; BCNG-2,889,96951,9.21,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08412:Ion_trans_N",HGNC:4846,Membrane,,"","",None,"216-236 241-261 289-309 318-338 370-390 414-435 441-461",Non Essential,1Q3E,HCN2,HCN2,AF064877,Chromosome:19,19p13.3 102,Tubulin delta chain,2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,Q9UJT1,"In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head (By similarity)","",">Tubulin delta chain MSIVTVQLGQCGNQIGFEVFDALLSDSHSSQGLCSMRENEAYQASCKERFFSEEENGVPIARAVLVDMEP KVINQMLSKAAQSGQWKYGQHACFCQKQGSGNNWAYGYSVHGPRHEESIMNIIRKEVEKCDSFSGFFIIM SMAGGTGSGLGAFVTQNLEDQYSNSLKMNQIIWPYGTGEVIVQNYNSILTLSHLYRSSDALLLHENDAIH KICAKLMNIKQISFSDINQVLAHQLGSVFQPTYSAESSFHYRRNPLGDLMEHLVPHPEFKMLSVRNIPHM SENSLAYTTFTWAGLLKHLRQMLISNAKMEEGIDRHVWPPLSGLPPLSKMSLNKDLHFNTSIANLVILRG KDVQSADVEGFKDPALYTSWLKPVNAFNVWKTQRAFSKYEKSAVLVSNSQFLVKPLDMIVGKAWNMFASK AYIHQYTKFGIEEEDFLDSFTSLEQVVASYCNL",TUBD1,Delta-tubulin,453,51035,6.83,">>> Function: structural molecule activity || >>> Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","",PF00091:Tubulin,HGNC:16811,"Centrosome, centriole. Cytoplasm. Nucleus",,"","",None,None,Non Essential,"",TUBD1,TUBD1,BC000258,Chromosome:17,17q23.1 103,Metal regulatory transcription factor 1,2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,Q14872,Activates the metallothionein I promoter. Binds to the metal responsive element (MRE),"",">Metal regulatory transcription factor 1 MGEHSPDNNIIYFEAEEDELTPDDKMLRFVDKNGLVPSSSGTVYDRTTVLIEQDPGTLEDEDDDGQCGEH LPFLVGGEEGFHLIDHEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRY QCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKA FNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHV RTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGHSYNALPQHNGSEDTNHSLCLSDLSLLSTDSEL RENSSTTQGQDLSTISPAIIFESMFQNSDDTAIQEDPQQTASLTESFNGDAESVSDVPPSTGNSASLSLP LVLQPGLSEPPQPLLPASAPSAPPPAPSLGPGSQQAAFGNPPALLQPPEVPVPHSTQFAANHQEFLPHPQ APQPIVPGLSVVAGASASAAAVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTITITPTPNTAI LQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEKVFFTTAVPVASSPGSSVQQIGLSVPVIIIKQEE ACQCQCACRDSAKERASSRRKGCSSPPPPEPSPQAPDGPSLQLPAQTFSSAPVPGSSSSTLPSSCEQSRQ AETPSDPQTETLSAMDVSEFLSLQSLDTPSNLIPIEALLQGEEEMGLTSSFSK",MTF1,Transcription factor MTF-1; MRE-binding transcription factor,753,80957,4.97,">>> Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: binding Function: nucleic acid binding || >>> Process: Not Available || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","Cell cycle control, cell division, chromosome partitioning",PF00096:zf-C2H2,HGNC:7428,Nucleus (Potential),,"","",None,None,Non Essential,"",MTF1,MTF1,BC014454,"","" 104,Steroid hormone receptor ERR2,2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,O95718,"","",">Steroid hormone receptor ERR2 MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGT PCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCP ATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLT KIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAW MEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALA NSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP MHKLFLEMLEAKAWARADSLQEWRPLEQVPSPLHRATKRQHVHFLTPLPPPPSVAWVGTAQAGYHLEVFL PQRAGWPRAA",ESRRB,"Estrogen-related receptor, beta; ERR-beta; Estrogen receptor-like 2; ERR beta-2; Nuclear receptor subfamily 3 group B member 2",500,55620,8.31,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:3473,Nucleus (Potential),,"","",None,None,Non Essential,"",ESRRB,ESRRB,AC008050,Chromosome:14,14q24.3 105,"Ferrochelatase, mitochondrial",2009-04-08 04:35:11 UTC,2009-06-30 03:51:40 UTC,P22830,Catalyzes the ferrous insertion into protoporphyrin IX,"",">Ferrochelatase, mitochondrial MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTG ILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQG EGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYY NQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEV SATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDI EYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS QQL",FECH,Protoheme ferro-lyase; Heme synthetase,423,47863,8.91,">>> Function: catalytic activity Function: lyase activity Function: ferrochelatase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis Process: heme biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00762:Ferrochelatase,HGNC:3647,Mitochondrion inner membrane,,"","",None,None,Non Essential,1HRK,FECH,FECH,AF495859,Chromosome:18,18q21.3 106,Alcohol dehydrogenase 4,2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,P08319,An alcohol + NAD(+) = an aldehyde or ketone + NADH,"",">Alcohol dehydrogenase 4 MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHE AAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKG KPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVG LSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSET MKAALDCTTAGWGSCTFIGVAAGSKGLTVFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDA LVTHTLPFDKISEAFDLMNQGKSIRTILIF",ADH4,Alcohol dehydrogenase class II pi chain,380,40222,8.01,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:252,Cytoplasm,,"","",None,None,Non Essential,"",ADH4,ADH4,BC022319,"","" 107,"Radical S-adenosyl methionine domain-containing protein 1, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,Q9HA92,May be involved in porphyrin cofactor biosynthesis (By similarity),"",">Radical S-adenosyl methionine domain-containing protein 1, mitochondrial MALPGARARGWAAAARAAQRRRRVENAGGSPSPEPAGRRAALYVHWPYCEKRCSYCNFNKYIPRRLEEAA MQKCLVTEAQTLLRLSGVQRVESVFFGGGTPSLASPHTVAAVLEAVAQAAHLPADLEVTLEANPTSAPGS RLAEFGAAGVNRLSIGLQSLDDTELRLLGRTHSACDALRTLAEARRLFPGRVSVDLMLGLPAQQVGPWLG QLQELLHHCDDHLSLYQLSLERGTALFAQVQRGALPAPDPELAAEMYQRGRAVLREAGFHQYEVSNFARN GALSTHNWTYWQCGQYLGVGPGAHGRFMPQGAGGHTREARIQTLEPDNWMKEVMLFGHGTRKRVPLGRLE LLEEVLALGLRTDVGITHQHWQQFEPQLTLWDVFGANKEVQELLERGLLQLDHRGLRCSWEGLAVLDSLL LTLLPQLQEAWQQRTPSPVPGG",RSAD1,Oxygen-independent coproporphyrinogen III oxidase-like protein RSAD1,442,48714,7.84,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-CH group of donors Function: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor Function: coproporphyrinogen oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis || >>> Component: cell Component: intracellular Component: cytoplasm",Coenzyme transport and metabolism,"PF06969:HemN_C PF04055:Radical_SAM",HGNC:25634,Mitochondrion (Potential),,"","",None,None,Non Essential,"",RSAD1,RSAD1,BC050538,Chromosome:17,17q21.33 108,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,P16615,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle,"",">Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAAC ISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRI KAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFS GTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFN DPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALC NDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRD RKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRC LALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGT AVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMT GDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGE VVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIG CYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCN ALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMD ETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVIWVYSTDTNFSDMFWS",ATP2A2,"SERCA2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; SR Ca(2+)-ATPase 2; Endoplasmic reticulum class 1/2 Ca(2+) ATPase",1042,114758,4.99,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: hydrogen transport Process: proton transport Process: metabolism Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:812,Endoplasmic reticulum membrane,,"","",None,"49-69 90-110 254-273 296-313 757-776 787-807 828-850 897-916 930-948 964-984",Non Essential,"",ATP2A2,ATP2A2,BC035588,Chromosome:12,12q23-q24.1 109,"Cytochrome c oxidase subunit 7C, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,P15954,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase subunit 7C, mitochondrial MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLKT",COX7C,Cytochrome c oxidase polypeptide VIIc,63,7246,10.88,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02935:COX7C,HGNC:2292,Mitochondrion inner membrane (By similarity),,"","",None,34-60,Non Essential,"",COX7C,COX7C,BC007498,"","" 110,Glutamate [NMDA] receptor subunit epsilon-4,2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,O15399,NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine,"",">Glutamate [NMDA] receptor subunit epsilon-4 MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLG PAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLP IVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDG SLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLA GGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRA QNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG RFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCID ILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETG ISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIG KSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQR PQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKD EGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKL DIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPP PPQPLPSPAYPAPGPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEA RAAPRGAAGRPLSPPAAQPPQKPPASYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAF EDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCCAAPPPCPYLDLEPSPSDSEDSES LGGASLGGLDPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLP PPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGW DLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFS SLESEV",GRIN2D,N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D; EB11,1336,143561,8.27,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","Secondary metabolites biosynthesis, transport and catabolism","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4588,Cell membrane,,"","",1-27,"584-604 657-677 845-865",Non Essential,"",GRIN2D,GRIN2D,U77783,Chromosome:19,19q13.1-qter 111,Gamma-aminobutyric-acid receptor subunit beta-2,2009-04-08 04:35:12 UTC,2009-07-22 22:35:22 UTC,P47870,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit beta-2 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIAS IDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMI RLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQF SIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGIT TVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANN EKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALER HVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN",GABRB2,GABA(A) receptor subunit beta-2,474,54607,9.66,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4082,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-25,"245-266 270-292 304-326 452-473",Non Essential,"",GABRB2,GABRB2,BC105639,"","" 112,"Phospholipid hydroperoxide glutathione peroxidase, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,P36969,Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity),"",">Phospholipid hydroperoxide glutathione peroxidase, mitochondrial MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVA SQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDA HPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF",GPX4,PHGPx; GPX-4,197,22175,8.48,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4556,Mitochondrion. Cytoplasm,,"","",None,None,Non Essential,"",GPX4,GPX4,BC039849,Chromosome:19,19p13.3 113,Ribonucleoside-diphosphate reductase large subunit,2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,P23921,Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides,"",">Ribonucleoside-diphosphate reductase large subunit MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTK HPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRD FSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGT NRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYN NTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSL MCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPE ACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSP VSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVL SGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGA FIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEK ERNTAAMVCSLENRDECLMCGS",RRM1,Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit,792,90071,7.16,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on CH2 groups Function: oxidoreductase activity, acting on CH2 groups, disulfide as acceptor Function: ribonucleoside-diphosphate reductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA replication || >>> Component: protein complex Component: ribonucleoside-diphosphate reductase complex",Nucleotide transport and metabolism,"PF03477:ATP-cone PF02867:Ribonuc_red_lgC PF00317:Ribonuc_red_lgN",HGNC:10451,Cytoplasm,,"","",None,None,Non Essential,"",RRM1,RRM1,BC006498,Chromosome:11,11p15.5 114,Plasma membrane calcium-transporting ATPase 2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:40 UTC,Q01814,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell,"",">Plasma membrane calcium-transporting ATPase 2 MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPG TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGG AEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVV GDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNS QTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQ QDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDT FVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETM GNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGA LPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEI VLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCI CVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEK GEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIA GTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQM LWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQID SGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFG GKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAE RELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDL EEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL",ATP2B2,PMCA2; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2,1243,136878,5.68,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: binding Function: ion binding Function: cation binding Function: calcium ion binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:815,Cell membrane,,"","",None,"95-115 153-173 391-410 444-461 876-895 906-926 947-969 988-1009 1029-1050 1061-1082",Non Essential,"",ATP2B2,ATP2B2,U15688,"","" 115,Gamma-aminobutyric-acid receptor subunit alpha-2,2009-04-08 04:35:12 UTC,2009-07-22 22:35:22 UTC,P47869,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-2 MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFT NIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMT MPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAP DGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVP ARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVV NDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM SRIVFPVLFGTFNLVYWATYLNREPVLGVSP",GABRA2,GABA(A) receptor subunit alpha-2,451,51327,9.50,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4076,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-28,"252-273 279-300 313-334 420-441",Non Essential,"",GABRA2,GABRA2,S62907,"","" 116,"Cytochrome c oxidase polypeptide 7A1, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,P24310,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 7A1, mitochondrial MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLCLGGTVYSLYS LGWASFPRN",COX7A1,Cytochrome c oxidase polypeptide VIIa-heart; Cytochrome c oxidase subunit VIIa-H; COX VIIa-M,79,9118,10.52,">>> Function: transporter activity Function: electron transporter activity Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02238:COX7a,HGNC:2287,Mitochondrion inner membrane,,"","",None,47-75,Non Essential,"",COX7A1,COX7A1,BC002757,Chromosome:19,19q13.1 118,Radical S-adenosyl methionine domain-containing protein 2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,Q8WXG1,"Involved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus","",">Radical S-adenosyl methionine domain-containing protein 2 MWVLTPAAFAGKLLSVFRQPLSSLWRSLVPLFCWLRATFWLLATKRRKQQLVLRGPDETKEEEEDPPLPT TPTSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKEAGMEKINFSGGEPFLQDRGEYLGKLV RFCKVELRLPSVSIVSNGSLIRERWFQNYGEYLDILAISCDSFDEEVNVLIGRGQGKKNHVENLQKLRRW CRDYRVAFKINSVINRFNVEEDMTEQIKALNPVRWKVFQCLLIEGENCGEDALREAERFVIGDEEFERFL ERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCRKGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKY IWSKADLKLDW",RSAD2,"Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible; Viperin; Cytomegalovirus-induced gene 5 protein",361,42170,8.33,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity || >>> Process: Not Available || >>> Component: Not Available",Coenzyme transport and metabolism,PF04055:Radical_SAM,HGNC:30908,Endoplasmic reticulum. Golgi apparatus,,"","",None,None,Non Essential,"",RSAD2,RSAD2,BC017969,"","" 119,Mitogen-activated protein kinase 15,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,Q8TD08,"In vitro, phosphorylates MBP","",">Mitogen-activated protein kinase 15 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDH PNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKP SNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGE MLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDL LRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSS GTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQ TALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPR LPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLEGHHV",MAPK15,Extracellular signal-regulated kinase 8,544,59833,9.18,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:24667,"",,"","",None,None,Non Essential,"",MAPK15,MAPK15,BC028034,"","" 120,Aquaporin-2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,P41181,"Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient","",">Aquaporin-2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPA VTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQ LVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLV GAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA",AQP2,AQP-2; Aquaporin-CD; AQP-CD; Water channel protein for renal collecting duct; ADH water channel; Collecting duct water channel protein; WCH-CD,271,28838,6.95,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:634,Apical cell membrane,,"","",None,"17-34 41-59 86-107 128-148 157-176 203-224",Non Essential,"",AQP2,AQP2,BC042496,Chromosome:12,12q12-q13 121,Retinoic acid receptor beta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,P10826,This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression,"",">Retinoic acid receptor beta MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEE LVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRC QYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTT NSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPE QDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDK LQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGH EPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ",RARB,RAR-beta; Nuclear receptor subfamily 1 group B member 2; RAR-epsilon; HBV-activated protein,455,50490,7.86,">>> Function: retinoic acid receptor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:9865,Isoform Beta-4:Cytoplasm,,"","",None,None,Non Essential,1XDK,RARB,RARB,M57445,"","" 122,Gap junction alpha-4 protein,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,P35212,"One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell","",">Gap junction alpha-4 protein MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNVCYDQAF PISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKDPQVERALAAVERQMAKISVA EDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFI IFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPT YNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNGQKPPSRPSSSASKKQYV",GJA4,Connexin-37; Cx37,333,37415,7.61,">>> Function: transporter activity Function: channel or pore class transporter activity Function: alpha-type channel activity Function: gap-junction forming channel activity Function: connexon channel activity || >>> Process: cellular process Process: cell communication || >>> Component: protein complex Component: connexon complex","",PF00029:Connexin,HGNC:4278,Cell membrane,,"","",None,"21-40 77-99 149-165 208-230",Non Essential,"",GJA4,GJA4,BC072389,"","" 123,Gamma-aminobutyric acid receptor subunit rho-3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,A8MPY1,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (By similarity)","",">Gamma-aminobutyric acid receptor subunit rho-3 MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQKYEQLLHIEDN DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIW VPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNED DLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAIL MVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAA VNYLTTVEERKQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSS RIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV",GABRR3,GABA(A) receptor subunit rho-3,467,54272,8.26,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","",PF02932:Neur_chan_memb,HGNC:17969,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-23,"267-287 300-320 332-352 447-467",Non Essential,"",GABRR3,GABRR3,Y18994,"","" 124,Calcineurin subunit B isoform 2,2009-04-08 04:35:12 UTC,2009-08-11 22:10:25 UTC,Q96LZ3,"Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity)","",">Calcineurin subunit B type 2 MGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHNPLVRRVIDVFDTDGDGEV DFKEFILGTSQFSVKGDEEQKLRFAFSIYDMDKDGYISNGELFQVLKMMVGNNLTDWQLQQLVDKTIIIL DKDGDGKISFEEFSAVVRDLEIHKKLVLIV",PPP3R2,Protein phosphatase 2B regulatory subunit 2; Protein phosphatase 3 regulatory subunit B beta isoform; Calcineurin B-like protein; CBLP; CNBII,170,19533,4.49,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: Not Available || >>> Component: Not Available","",PF00036:efhand,HGNC:9318,"",,"","",None,None,Non Essential,"",PPP3R2,PPP3R2,AF085237,"","" 125,Tubulin epsilon chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,Q9UJT0,"","",">Tubulin epsilon chain MTQSVVVQVGQCGNQIGCCFWDLALREHAAVNQKGIYDEAISSFFRNVDTRVVGDGGSISKGKICSLKAR AVLIDMEEGVVNEILQGPLRDVFDTKQLITDISGSGNNWAVGHKVFGSLYQDQILEKFRKSAEHCDCLQC FFIIHSMGGGTGSGLGTFLLKVLEDEFPEVYRFVTSIYPSGEDDVITSPYNSILAMKELNEHADCVLPID NQSLFDIISKIDLMVNSGKLGTTVKPKSLVTSSSGALKKQHKKPFDAMNNIVANLLLNLTSSARFEGSLN MDLNEISMNLVPFPQLHYLVSSLTPLYTLTDVNIPPRRLDQMFSDAFSKDHQLLRADPKHSLYLACALMV RGNVQISDLRRNIERLKPSLQFVSWNQEGWKTSLCSVPPVGHSHSLLALANNTCVKPTFMELKERFMRLY KKKAHLHHYLQVEGMEESCFTEAVSSLSALIQEYDQLDATKNMPVQDLPRLSIAM",TUBE1,Epsilon-tubulin,475,52933,6.62,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20775,Centrosome,,"","",None,None,Non Essential,"",TUBE1,TUBE1,BC031101,"","" 126,Glutamate [NMDA] receptor subunit zeta-1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,Q05586,"NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity)","",">Glutamate [NMDA] receptor subunit zeta-1 MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPN AIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRT VPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLME AKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAH ISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFAN YSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERV NNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQS TLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSAR ILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELS TMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQ NVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQ NQKDTVLPRRAIEREEGQLQLCSRHRES",GRIN1,N-methyl-D-aspartate receptor subunit NR1,938,105374,9.20,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4584,Cell membrane,,"","",1-18,"560-580 637-657 813-833",Non Essential,1PB7,GRIN1,GRIN1,S57708,"","" 127,Gamma-aminobutyric-acid receptor subunit rho-1,2009-04-08 04:35:12 UTC,2009-07-22 22:36:00 UTC,P24046,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission","",">Gamma-aminobutyric acid receptor subunit rho-1 MRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSE QLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFD GRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEI ESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLL QTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVF LSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQ LTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS",GABRR1,GABA(A) receptor subunit rho-1,473,55258,8.86,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4090,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-15,"276-299 303-325 337-359 452-473",Non Essential,"",GABRR1,GABRR1,AL353135,"","" 128,Thyrotropin subunit beta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,P01222,Indispensable for the control of thyroid structure and metabolism,"",">Thyrotropin subunit beta MTALFLMSMLFGLACGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQD VCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV",TSHB,Thyrotropin beta chain; Thyroid-stimulating hormone subunit beta; TSH-beta; TSH-B; Thyrotropin alfa,138,15609,7.75,">>> Function: signal transducer activity Function: receptor binding Function: hormone activity || >>> Process: Not Available || >>> Component: extracellular region","",PF00007:Cys_knot,HGNC:12372,Secreted,,"","",1-20,None,Non Essential,"",TSHB,TSHB,BC069298,"","" 129,Epididymal secretory glutathione peroxidase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,O75715,"Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathionine peroxidase-like protective system against peroxide damage in sperm membrane lipids","",">Epididymal secretory glutathione peroxidase MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYVGKHILFVNVA TYCGLTAQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDNKEILPGLKYVRPGGGFVPSFQLFEKGDV NGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIRWNFEKFLVGPDGIPVMRWSHRATVSSVKTD ILAYLKQFKTK",GPX5,Epididymis-specific glutathione peroxidase-like protein; EGLP,221,25203,8.89,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4557,Secreted,,"","",1-21,None,Non Essential,"",GPX5,GPX5,AL049543,"","" 130,Potassium voltage-gated channel subfamily H member 6,2009-04-08 04:35:12 UTC,2009-06-30 03:51:41 UTC,Q9H252,"Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly","",">Potassium voltage-gated channel subfamily H member 6 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQPCTCDFLT GPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKCS SRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPH KVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAF LLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDM VAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY AIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEK VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYT NGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLST LYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAF AESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSM GAGPCAPGHPDAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPK HRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQ RHGSDPGFAGSWGH",KCNH6,Voltage-gated potassium channel subunit Kv11.2; Ether-a-go-go-related gene potassium channel 2; Ether-a-go-go-related protein 2; Eag-related protein 2,994,109926,7.00,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF00989:PAS",HGNC:18862,Membrane,,"","",None,"262-282 299-319 341-361 371-391 399-419 491-511",Non Essential,"",KCNH6,KCNH6,BC006334,Chromosome:17,17q23.3 131,"DNA polymerase subunit gamma-2, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,Q9UHN1,"Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA","",">DNA polymerase subunit gamma-2, mitochondrial MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALL EICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLP GDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGKLRENLLHGALEHYVNCLDLVNKRLPYGLAQ IGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQD EEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYL YDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLET MQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV",POLG2,Mitochondrial DNA polymerase accessory subunit; PolG-beta; MtPolB; DNA polymerase gamma accessory 55 kDa subunit; p55,485,54912,8.48,">>> Function: glycine-tRNA ligase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: ligase activity Function: ligase activity, forming phosphoric ester bonds Function: RNA ligase activity Function: tRNA ligase activity || >>> Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: RNA metabolism Process: tRNA metabolism Process: tRNA aminoacylation Process: tRNA aminoacylation for protein translation Process: glycyl-tRNA aminoacylation Process: physiological process Process: metabolism Process: macromolecule metabolism Process: macromolecule biosynthesis Process: protein biosynthesis || >>> Component: Not Available","Translation, ribosomal structure and biogenesis",PF03129:HGTP_anticodon,HGNC:9180,Mitochondrion,,"","",None,None,Non Essential,"",POLG2,POLG2,U94703,Chromosome:17,17q 132,C-jun-amino-terminal kinase-interacting protein 3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,Q9UPT6,"The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins (By similarity)","",">C-jun-amino-terminal kinase-interacting protein 3 MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVL SENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKA KNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNV FPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSV PSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPE LDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEA IIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE HPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTAGFSQRRNHAMCPISAGSRPLEFFP DDDCTSSARREQKREQYRQVREHVRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVE KDPTMKLWCAAGVNLSGWRPNEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATS SRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATEVPDPGPSEPE TATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDPTGAGSSAAPTMWLGAQNGWL YVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIR CMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQ HLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKT SPTSGEGARPGGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQ VSYTPE",MAPK8IP3,JNK-interacting protein 3; JIP-3; JNK MAP kinase scaffold protein 3; Mitogen-activated protein kinase 8-interacting protein 3,1336,147458,5.08,"",Transcription,"",HGNC:6884,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",MAPK8IP3,MAPK8IP3,AL031717,Chromosome:16,16p13.3 133,Gamma-aminobutyric-acid receptor subunit alpha-5,2009-04-08 04:35:12 UTC,2009-07-22 22:35:21 UTC,P31644,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-5 MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGE RITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKK SIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGST KSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFW LNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWA WDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK",GABRA5,GABA(A) receptor subunit alpha-5,462,52147,9.56,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4079,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-31,"260-281 286-307 319-341 428-449",Non Essential,"",GABRA5,GABRA5,AF061785,Chromosome:15,15q11.2-q12 134,Tubulin alpha-8 chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,Q9NY65,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-8 chain MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGKHVPRAVMIDL EPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHS FGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEK AYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDLAALEKDYEEVGTDSFEEENEGEEF",TUBA8,Alpha-tubulin 8; Tubulin alpha chain-like 2,449,50094,4.70,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12410,Cytoplasmic,,"","",None,None,Non Essential,"",TUBA8,TUBA8,BC104845,Chromosome:22,22q11.1 135,Gamma-aminobutyric acid receptor subunit gamma-3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,Q99928,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit gamma-3 MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKP TVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAE AHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEA ADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKD ATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTK KTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCC YEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL",GABRG3,GABA(A) receptor subunit gamma-3,467,54289,7.58,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4088,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-17,"255-277 281-303 315-337 444-467",Non Essential,"",GABRG3,GABRG3,AF228458,Chromosome:15,15q12 136,Tubulin beta-4 chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P04350,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin beta-4 chain MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYVPRAVLVDLEP GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVK TAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEGEFEEEAEEEVA",TUBB4,Tubulin 5 beta,444,49586,4.51,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20774,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB4,TUBB4,BC013683,Chromosome:19,19p13.3 137,"HLA class II histocompatibility antigen, DRB1-11 beta chain",2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P20039,"","",">HLA class II histocompatibility antigen, DRB1-11 beta chain MVCLRLPGGSCMAVLTVTLMVLSSPLALAGDTRPRFLEYSTSECHFFNGTERVRFLDRYFYNQEEYVRFD SDVGEFRAVTELGRPDEEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVHPKVTVYPSKTQPLQH HNLLVCSVSGFYPGSIEVRWFRNGQEEKTGVVSTGLIHNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVT SPLTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPRGFLS",HLA-DRB1,MHC class I antigen DRB1*11; DRw11; DR-5; DR5,266,30160,7.20,">>> Function: Not Available || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response || >>> Component: cell Component: membrane","","PF07654:C1-set PF00969:MHC_II_beta",HGNC:4948,Membrane,,"","",1-29,228-250,Non Essential,"",HLA-DRB1,HLA-DRB1,AJ297587,"","" 138,Uroporphyrinogen decarboxylase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P06132,Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen III to yield coproporphyrinogen III,"",">Uroporphyrinogen decarboxylase MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTL QPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITL TRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAG AQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVV GLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHV GAFVDAVHKHSRLLRQN",UROD,URO-D; UPD,367,40787,6.06,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity Function: uroporphyrinogen decarboxylase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF01208:URO-D,HGNC:12591,Cytoplasm,,"","",None,None,Non Essential,1R3Y,UROD,UROD,M60891,"","" 139,Cystathionine beta-synthase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P35520,L-serine + L-homocysteine = L-cystathionine + H(2)O,"",">Cystathionine beta-synthase MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPASESPHHHTAP AKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGD TIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRL KNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGV DPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSA GSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLS APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQI RLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK",CBS,Serine sulfhydrase; Beta-thionase,551,60587,6.63,">>> Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: cystathionine beta-synthase activity || >>> Process: sulfur amino acid metabolism Process: sulfur amino acid biosynthesis Process: cysteine biosynthesis Process: cysteine biosynthesis via cystathione Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: serine family amino acid metabolism Process: L-serine metabolism Process: cysteine biosynthesis from serine || >>> Component: cell Component: intracellular Component: cytoplasm",Amino acid transport and metabolism,"PF00571:CBS PF00291:PALP",HGNC:1550,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1JBQ,CBS,CBS,BC011381,Chromosome:21,21q22.3 140,Glycine N-methyltransferase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,Q14749,Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine,"",">Glycine N-methyltransferase MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGV DSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLDKDVPQSAEGGFDAVICLG NSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLTKDVTTSVL IVNNKAHMVTLDYTVQVPGAGQDGSPGLSKFRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQ TYIPCYFIHVLKRTD",GNMT,"",295,32743,7.03,"","Secondary metabolites biosynthesis, transport and catabolism",PF08242:Methyltransf_12,HGNC:4415,Cytoplasm,,"","",None,None,Non Essential,1R74,GNMT,GNMT,X62250,"","" 141,Ig kappa chain V-III region WOL,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P01623,"","",">Ig kappa chain V-III region WOL EIVLTQSPGTLSLSPGERATLSCRASQSVSSGYLGWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGT DFTLTISRLEPEDFAVYYCQQYGSLGRTFGQGTKVEIKR","","",109,11746,9.12,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 142,Tumor necrosis factor,2009-04-08 04:35:12 UTC,2009-06-30 03:51:42 UTC,P01375,"Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation","",">Tumor necrosis factor MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLI SPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLF KGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSA EINRPDYLDFAESGQVYFGIIAL",TNF,"TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin; Contains: RecName: Tumor necrosis factor, membrane form; Contains: RecName: Tumor necrosis factor, soluble form",233,25645,6.92,">>> Function: signal transducer activity Function: receptor binding Function: cytokine activity Function: tumor necrosis factor receptor binding || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response || >>> Component: cell Component: membrane","",PF00229:TNF,HGNC:11892,"Tumor necrosis factor, soluble form:Secreted",,REACT_578-Apoptosis;,"",None,36-56,Non Essential,1A8M,TNF,TNF,AF098751,"","" 143,Protein kinase C delta type,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q05655,"This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin","",">Protein kinase C delta type MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQ IVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFP TMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTG TAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC GINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFI FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIA DFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESI RVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDY SNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED",PRKCD,nPKC-delta,676,77506,7.81,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9399,Cytoplasm (By similarity). Membrane,,"","",None,None,Non Essential,"",PRKCD,PRKCD,D10495,"","" 144,Thyroid peroxidase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P07202,Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4),"",">Thyroid peroxidase MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSP AQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPP KCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTR HVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARP AAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLL RVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAF RFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEEL TERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPD NIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTG LTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRH GYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQAVGTSPQRAA AQDSEQESAGMEGRDTHRLPRAL",TPO,TPO,933,102964,6.75,">>> Function: antioxidant activity Function: peroxidase activity Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","","PF03098:An_peroxidase PF07645:EGF_CA PF00084:Sushi",HGNC:12015,Membrane,,"","",1-14,847-871,Non Essential,"",TPO,TPO,M55702,"","" 145,Tubulin alpha-1C chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q9BQE3,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-1C chain MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDL EPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHS FGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGADSADGEDEGEEY",TUBA1C,Tubulin alpha-6 chain; Alpha-tubulin 6,449,49896,4.73,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20768,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA1C,TUBA1C,BC063036,Chromosome:12,12q12-q14 146,"Cytochrome c oxidase subunit 6A1, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P12074,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 6A1, mitochondrial MAVVGVSSVSRLLGRSRPQLGRPMSSGAHGEEGSARMWKTLTFFVALPGVAVSMLNVYLKSHHGEHERPE FIAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE",COX6A1,Cytochrome c oxidase polypeptide VIa-liver,109,12155,9.70,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: envelope Component: organelle envelope Component: mitochondrial envelope","",PF02046:COX6A,HGNC:2277,Mitochondrion inner membrane,"","","",None,None,Non Essential,"",COX6A1,COX6A1,X15341,Chromosome:12,12q24.2|12q24.2 147,Tubulin alpha-3C/D chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q13748,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-3C/D chain MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDL EPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHS FGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDLAALEKDYEEVGVDSVEAEAEEGEEY",TUBA3C,Alpha-tubulin 3C/D; Tubulin alpha-2 chain; Alpha-tubulin 2,450,49960,4.74,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12408,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA3C,TUBA3C,L11645,Chromosome:13,13q11 148,Glutathione peroxidase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P07203,Protects the hemoglobin in erythrocytes from oxidative breakdown,"",">Glutathione peroxidase 1 MCAARLAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNELQRRLGPRGLV VLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATA LMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA",GPX1,GSHPx-1; GPx-1; Cellular glutathione peroxidase,201,21946,6.51,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4553,Cytoplasm,,"","",None,None,Non Essential,"",GPX1,GPX1,BC000742,"","" 149,Histone deacetylase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q13547,"Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes","",">Histone deacetylase 1 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSD DYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLH HAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGD LRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKG HAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNM TNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA",HDAC1,HD1,482,55104,5.16,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Function: histone deacetylase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid deacetylation Process: histone deacetylation || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus",Chromatin structure and dynamics,PF00850:Hist_deacetyl,HGNC:4852,Nucleus,,"","",None,None,Non Essential,"",HDAC1,HDAC1,BC000301,"","" 150,Copper-transporting ATPase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q04656,"May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells","",">Copper-transporting ATPase 1 MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMG FDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIK ELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQE ATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTAT FIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSE VESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVE YDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKC YIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENAD EGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEAS LVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMTYMMVMDHHFATLHHNQNMSKEEMINLHSSMF LERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMY ERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVE LVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGAD TTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISR TETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTIT HGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGIS CKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQHKVLIGNREWMIR NGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKT ARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAAD VVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSV VLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSD KRSLNSVVTSEPDKHSLLVGDFREDDDTAL",ATP7A,Copper pump 1; Menkes disease-associated protein,1500,163337,6.31,">>> Function: mercury ion transporter activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: cation binding Function: transition metal ion binding Function: copper ion binding Function: metal ion transporter activity Function: ion binding Function: metal ion binding Function: di-, tri-valent inorganic cation transporter activity Function: copper ion transporter activity Function: copper-exporting ATPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: mercury ion transport Process: metabolism Process: di-, tri-valent inorganic cation transport Process: transition metal ion transport Process: copper ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: metal ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Inorganic ion transport and metabolism,"PF00122:E1-E2_ATPase PF00403:HMA PF00702:Hydrolase",HGNC:869,Isoform 5:Endoplasmic reticulum,,"","",None,"654-675 715-734 742-762 782-802 937-959 990-1011 1357-1374 1386-1405",Non Essential,1Q8L,ATP7A,ATP7A,AY011418,"","" 151,"Actin, cytoplasmic 2",2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P63261,Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells,"",">Actin, cytoplasmic 2 MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYP IEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVL SLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVR DIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFN SIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLS TFQQMWISKQEYDESGPSIVHRKCF",ACTG1,Gamma-actin,375,41793,5.16,">>> Function: binding Function: protein binding Function: structural molecule activity Function: structural constituent of cytoskeleton Function: motor activity || >>> Process: Not Available || >>> Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: actin cytoskeleton Component: actin filament",Cytoskeleton,PF00022:Actin,HGNC:144,"Cytoplasm, cytoskeleton",,"","",None,None,Non Essential,1HLU,ACTG1,ACTG1,M16247,Chromosome:17,17q25 152,Cytochrome P450 2B6,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P20813,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics","",">Cytochrome P450 2B6 MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHL GPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKR SVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLIS SVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAH SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTE AVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP R",CYP2B6,CYPIIB6; P450 IIB1,491,56279,8.44,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2615,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP2B6,CYP2B6,AC023172,Chromosome:19,19q13.2 153,Gamma-aminobutyric-acid receptor subunit alpha-3,2009-04-08 04:35:12 UTC,2009-07-22 22:35:21 UTC,P34903,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-3 MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRI LDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNN LLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFG SYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVI QTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVF SALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGA APSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIR KQ",GABRA3,GABA(A) receptor subunit alpha-3,492,55165,8.93,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4077,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-28,"277-298 304-325 338-359 458-479",Non Essential,"",GABRA3,GABRA3,BC028629,"","" 154,Calcium-transporting ATPase type 2C member 2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,O75185,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity),"",">Calcium-transporting ATPase type 2C member 2 MLHFHLLKFKTRVIFSAVIIMVTGLCLFLLSLPHLHGVFEQVPAPWWTSLCPWPIMEAAAFQSGSLYPVA SFLAAPMSELVPDLSFQVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSAL VSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVS LSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIG TGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVA AIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAE VSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDI KNSYIRKKEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQE EKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRN IGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALK SADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVF NLPSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFI FWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIP PLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV",ATP2C2,ATPase 2C2,963,105038,5.79,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: hydrogen transport Process: proton transport Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:29103,Membrane,,"","",None,"119-139 152-170 309-328 341-358 747-766 777-797 818-840 857-876 890-908 924-944",Non Essential,"",ATP2C2,ATP2C2,"",Chromosome:16,16q24.1 155,G1/S-specific cyclin-D1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P24385,Essential for the control of the cell cycle at the G1/S (start) transition,"",">G1/S-specific cyclin-D1 MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEE QKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQM ELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVA AVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEE VDLACTPTDVRDVDI",CCND1,PRAD1 oncogene; BCL-1 oncogene,295,33729,4.68,">>> Function: Not Available || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of cellular physiological process Process: regulation of cell cycle Process: regulation of progression through cell cycle || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF02984:Cyclin_C PF00134:Cyclin_N",HGNC:1582,"",,"","",None,None,Non Essential,"",CCND1,CCND1,L09054,Chromosome:11,11q13 156,Arsenite methyltransferase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q9HBK9,"Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity)","",">Arsenite methyltransferase MAALRDAEIQKDVQTYYGQVLKRSADLQTNGCVTTARPVPKHIREALQNVHEEVALRYYGCGLVIPEHLE NCWILDLGSGSGRDCYVLSQLVGEKGHVTGIDMTKGQVEVAEKYLDYHMEKYGFQASNVTFIHGYIEKLG EAGIKNESHDIVVSNCVINLVPDKQQVLQEAYRVLKHGGELYFSDVYTSLELPEEIRTHKVLWGECLGGA LYWKELAVLAQKIGFCPPRLVTANLITIQNKELERVIGDCRFVSATFRLFKHSKTGPTKRCQVIYNGGIT GHEKELMFDANFTFKEGEIVEVDEETAAILKNSRFAQDFLIRPIGEKLPTSGGCSALELKDIITDPFKLA EESDSMKSRCVPDAAGGCCGTKKSC",AS3MT,S-adenosyl-L-methionine:arsenic(III) methyltransferase; Methylarsonite methyltransferase,375,41748,6.14,"","Secondary metabolites biosynthesis, transport and catabolism",PF08241:Methyltransf_11,HGNC:17452,Cytoplasm (By similarity),,"","",None,None,Non Essential,"",AS3MT,AS3MT,CH471066,Chromosome:10,10q24.32 157,Cyclic AMP-dependent transcription factor ATF-1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,P18846,"This protein binds the cAMP response element (CRE) (consensus:5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes","",">Cyclic AMP-dependent transcription factor ATF-1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKD LSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSG STQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTD DPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV",ATF1,Activating transcription factor 1; TREB36 protein,271,29233,8.64,">>> Function: transcription factor activity Function: protein binding Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00170:bZIP_1 PF02173:pKID",HGNC:783,Nucleus,,"","",None,None,Non Essential,"",ATF1,ATF1,BC029619,Chromosome:12,12q13 158,Glutamate [NMDA] receptor subunit epsilon-3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:43 UTC,Q14957,NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine,"",">Glutamate [NMDA] receptor subunit epsilon-3 MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGVN TTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSAFL QLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRA RTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTES WRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPG GYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGV WNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMF VMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVL VWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMH THMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWK RAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVS SSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGR PPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASERPLSPARCHYSSFPRADRSGRPFLPLFPEPP ELEDLPLLGPEQLARREALLHAAWARGSRPRHASLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRL AQAQSMCLPIYREACQEGEQAGAPAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGH RGRTLGLGTGYRDSGGLDEISRVARGTQGFPGPCTWRRISSLESEV",GRIN2C,N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C,1236,134534,8.50,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","Cell cycle control, cell division, chromosome partitioning","PF01094:ANF_receptor PF00060:Lig_chan",HGNC:4587,Cell membrane,,"","",1-19,"554-574 627-647 815-835",Non Essential,"",GRIN2C,GRIN2C,BC140801,Chromosome:17,17q25 159,Cellular tumor antigen p53,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P04637,"Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression","",">Cellular tumor antigen p53 MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAA PRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKT CPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRN TFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGR DRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALEL KDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD",TP53,Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13,393,43713,6.93,">>> Function: transcription factor activity Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00870:P53 PF08563:P53_TAD PF07710:P53_tetramer",HGNC:11998,Cytoplasm. Nucleus. Endoplasmic reticulum,,"","",None,None,Non Essential,1TSR,TP53,TP53,AY270155,Chromosome:17,17p13.1 160,Transcription factor EC,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,O14948,Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form,"",">Transcription factor EC MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVIEDIIG MESSFKEEGADSPLLMQRTLSGSILDVYSGEQGISPINMGLTSASCPSSLPMKREITETDTRALAKERQK KDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLE QANRRLLLRIQELEIQARTHGLPTLASLGTVDLGAHVTKQQSHPEQNSVDYCQQLTVSQGPSPELCDQAI AFSDPLSYFTDLSFSAALKEEQRLDGMLLDDTISPFGTDPLLSATSPAVSKESSRRSSFSSDDGDEL",TFEC,Protein TFE-C; Transcription factor EC-like; hTFEC-L,347,38788,5.16,">>> Function: transcription regulator activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","",PF00010:HLH,HGNC:11754,Nucleus,,"","",None,None,Non Essential,"",TFEC,TFEC,AJ608795,"","" 161,Potassium voltage-gated channel subfamily H member 2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,Q12809,"Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1","",">Potassium voltage-gated channel subfamily H member 2 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLH GPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGS PAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESL ALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVR RASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLA SPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIA VHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALI AHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNV SPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEY FQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLV HAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLE VLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGP GRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKS SDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLN RLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEEL PPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS",KCNH2,Voltage-gated potassium channel subunit Kv11.1; Ether-a-go-go-related gene potassium channel 1; H-ERG; Erg1; Ether-a-go-go-related protein 1; Eag-related protein 1; eag homolog,1159,126656,7.97,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF00989:PAS",HGNC:6251,Membrane,,"","",None,"404-424 451-471 496-516 521-541 548-568 639-659",Non Essential,1BYW,KCNH2,KCNH2,BC004311,"","" 162,"Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3",2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P42771,Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein,"",">Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEP NCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGS NHARIDAAEGPSDIPD",CDKN2A,Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; Multiple tumor suppressor 1; MTS-1,156,16533,5.60,"","",PF00023:Ank,HGNC:1787,"",,"","",None,None,Non Essential,1DC2,CDKN2A,CDKN2A,S69804,"","" 163,Sodium/potassium-transporting ATPase subunit beta-2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P14415,"This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known","",">Sodium/potassium-transporting ATPase subunit beta-2 MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSDHT PKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDN GVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAEN LGNFVMFPANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGR VAFKLRINKT",ATP1B2,Sodium/potassium-dependent ATPase subunit beta-2,290,33367,8.44,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: sodium:potassium-exchanging ATPase activity || >>> Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF00287:Na_K-ATPase,HGNC:805,Membrane,,"","",None,40-67,Non Essential,"",ATP1B2,ATP1B2,BC126175,Chromosome:17,17p13.1 164,Ig heavy chain V-III region POM,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P01774,"","",">Ig heavy chain V-III region POM EVQLLESGGGLVQPGGSLRLSCAASGFTFSSSAMSWVRQAPGKGLEWVAWKYENGNDKHYADSVNGRFTI SRNDSKNTLYLLMNSLQAZBTALYYCARDAGPYVSPTFFAHYGQGTLVT","","",119,12953,8.19,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 165,GTPase KRas,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P01116,Ras proteins bind GDP/GTP and possess intrinsic GTPase activity,"",">GTPase KRas MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQ YMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIP FIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM",KRAS,K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras,189,21656,6.76,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding || >>> Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade Process: small GTPase mediated signal transduction || >>> Component: Not Available","",PF00071:Ras,HGNC:6407,Cell membrane,,"","",None,None,Non Essential,"",KRAS,KRAS,K03210,Chromosome:12,12p12.1 166,Mitogen-activated protein kinase 4,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P31152,Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle,"",">Mitogen-activated protein kinase 4 MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIR RLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYI HSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAI DMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPE VNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNW DTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAF EADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLF LEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNK LGDLNGACIPEHPGDLVQTEAFSKERW",MAPK4,Extracellular signal-regulated kinase 4; ERK-4; MAP kinase isoform p63; p63-MAPK,587,65922,5.11,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6878,"",,"","",None,None,Non Essential,"",MAPK4,MAPK4,X59727,Chromosome:18,18q12-q21 167,Hemoglobin subunit zeta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P02008,"The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac","",">Hemoglobin subunit zeta MSLTKTERTIIVSMWAKISTQADTIGTETLERLFLSHPQTKTYFPHFDLHPGSAQLRAHGSKVVAAVGDA VKSIDDIGGALSKLSELHAYILRVDPVNFKLLSHCLLVTLAARFPADFTAEAHAAWDKFLSVVSSVLTEK YR",HBZ,Hemoglobin zeta chain; Zeta-globin; HBAZ,142,15637,8.51,">>> Function: oxygen binding Function: binding || >>> Process: gas transport Process: oxygen transport Process: physiological process Process: cellular physiological process Process: transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4835,"",,"","",None,None,Non Essential,1JEB,HBZ,HBZ,BC027892,Chromosome:16,16p13.3 168,Protein kinase C theta type,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,Q04759,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters","",">Protein kinase C theta type MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVM QIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFF ALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCT GSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANL CGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPL DEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIIL GLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSV DWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQ HPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPG MERLIS",PRKCQ,nPKC-theta,706,81866,7.64,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9410,"",,"","",None,None,Non Essential,1XJD,PRKCQ,PRKCQ,BC113359,Chromosome:10,10p15 169,Tyrosine aminotransferase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P17735,L-tyrosine + 2-oxoglutarate = 4- hydroxyphenylpyruvate + L-glutamate,"",">Tyrosine aminotransferase MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPN KTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVIL TSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTA CLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAK RWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNA DLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVI TVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK",TAT,TAT; L-tyrosine:2-oxoglutarate aminotransferase,454,50400,6.24,">>> Function: binding Function: vitamin binding Function: pyridoxal phosphate binding Function: transaminase activity Function: tyrosine transaminase activity Function: transferase activity Function: transferase activity, transferring nitrogenous groups Function: catalytic activity Function: lyase activity Function: carbon-sulfur lyase activity Function: 1-aminocyclopropane-1-carboxylate synthase activity || >>> Process: aromatic amino acid family metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: amino acid catabolism Process: aromatic amino acid family catabolism Process: physiological process Process: metabolism Process: biosynthesis || >>> Component: Not Available",Amino acid transport and metabolism,"PF00155:Aminotran_1_2 PF07706:TAT_ubiq",HGNC:11573,"",,"","",None,None,Non Essential,"",TAT,TAT,X55675,Chromosome:16,16q22.1 170,Cytochrome c oxidase subunit 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P00395,Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B,"",">Cytochrome c oxidase subunit 1 MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMV MPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPG ASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLL TDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSI GFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTV GGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIG VNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSM NLEWLYGCPPPYHTFEEPVYMKS",MT-CO1,Cytochrome c oxidase polypeptide I,513,57042,6.70,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane",Energy production and conversion,PF00115:COX1,HGNC:7419,Mitochondrion inner membrane,,"","",None,"20-42 57-79 100-122 147-169 182-204 236-258 271-293 303-325 337-359 374-396 409-431 451-473",Non Essential,1OCZ,MT-CO1,MT-CO1,M10546,"Chromosome:MT   
HGNC chromosome: mitochondria","" 171,"Thioredoxin reductase 1, cytoplasmic",2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,Q16881,"Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid","",">Thioredoxin reductase 1, cytoplasmic MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVI FSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAY QEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCV NVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENA YGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASY VALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKV ELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLE WTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFT TLSVTKRSGASILQAGCUG",TXNRD1,TR; Thioredoxin reductase TR1; KM-102-derived reductase-like factor; Gene associated with retinoid-IFN-induced mortality 12 protein; GRIM-12,649,70907,7.42,">>> Function: oxidoreductase activity, acting on NADH or NADPH Function: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor Function: disulfide oxidoreductase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: catalytic activity Function: oxidoreductase activity Function: transporter activity Function: electron transporter activity || >>> Process: homeostasis Process: cell homeostasis Process: cell redox homeostasis Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: intracellular Component: cytoplasm",Energy production and conversion,"PF00462:Glutaredoxin PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim",HGNC:12437,Isoform 5:Cytoplasm,,"","",None,None,Non Essential,1H6V,TXNRD1,TXNRD1,BC018122,Chromosome:12,12q23-q24.1 172,Carbonic anhydrase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P00915,Reversible hydration of carbon dioxide,"",">Carbonic anhydrase 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVN FEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKAD GLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTW IICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF",CA1,Carbonic anhydrase I; CA-I; Carbonate dehydratase I; Carbonic anhydrase B; CAB,261,28870,7.14,">>> Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: carbonate dehydratase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: one-carbon compound metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00194:Carb_anhydrase,HGNC:1368,Cytoplasm,,"","",None,None,Non Essential,1CZM,CA1,CA1,BC027890,"","" 173,Proto-oncogene tyrosine-protein kinase LCK,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P06239,"Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR","",">Proto-oncogene tyrosine-protein kinase LCK MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALH SYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQ LLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYT NASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM SPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYL RSVLEDFFTATEGQYQPQP",LCK,Lymphocyte cell-specific protein-tyrosine kinase; p56-LCK; LSK; T cell-specific protein-tyrosine kinase,509,58001,5.03,">>> Function: protein-tyrosine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","","PF07714:Pkinase_Tyr PF00017:SH2 PF00018:SH3_1",HGNC:6524,Cytoplasm. Cell membrane,,"","",None,None,Non Essential,"",LCK,LCK,X04476,"","" 174,"Alkaline phosphatase, placental-like",2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P10696,A phosphate monoester + H(2)O = an alcohol + phosphate,"",">Alkaline phosphatase, placental-like MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTA ARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQC NTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLI SNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPS VTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTET IMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPY TACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP",ALPPL2,Alkaline phosphatase Nagao isozyme; Germ cell alkaline phosphatase; GCAP; PLAP-like; ALP-1,532,57378,6.31,">>> Function: Not Available || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00245:Alk_phosphatase,HGNC:441,Cell membrane,,"","",1-19,None,Non Essential,1EW2,ALPPL2,ALPPL2,X07247,"","" 175,DNA topoisomerase 2-alpha,2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,P11388,Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks,"",">DNA topoisomerase 2-alpha MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGI NYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPAL IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFN GEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLD ETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVA VKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKI LNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHN WPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFAD MKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFIN KELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIIN LAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVIS GEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEA ERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNN QARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTD SGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQ VGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDL DSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFP DETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPST SDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF",TOP2A,"DNA topoisomerase II, alpha isozyme",1531,174387,9.17,">>> Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: DNA topoisomerase activity Function: DNA topoisomerase (ATP-hydrolyzing) activity Function: nucleic acid binding Function: DNA binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: DNA topological change Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism || >>> Component: Not Available","Replication, recombination and repair","PF00204:DNA_gyraseB PF00521:DNA_topoisoIV PF08070:DTHCT PF02518:HATPase_c",HGNC:11989,"Cytoplasm. Nucleus, nucleoplasm",,"","",None,None,Non Essential,"",TOP2A,TOP2A,AF064590,Chromosome:17,17q21-q22 176,"Cytochrome c oxidase subunit 8C, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:44 UTC,Q7Z4L0,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 8C, mitochondrial MPLLRGRCPARRHYRRLALLGLQPAPRFAHSGPPRQRPLSAAEMAVGLVVFFTTFLTPAAYVLGNLKQFR RN",COX8C,Cytochrome c oxidase polypeptide 8 isoform 3; Cytochrome c oxidase polypeptide VIII isoform 3; Cytochrome c oxidase subunit 8-3; COX VIII-3,72,8129,12.58,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02285:COX8,HGNC:24382,Mitochondrion inner membrane,"","","",None,41-64,Non Essential,"",COX8C,COX8C,BC101126,Chromosome:14,14q32.13 177,Aquaporin-8,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,O94778,Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea,"",">Aquaporin-8 MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIGCLSVIENGTDTGLLQPAL AHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNA SGAAFVTVQEQGQVAGALVAEIILTTLLALAVCMGAINEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMN PARAFGPAVVANHWNFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR",AQP8,AQP-8,261,27382,6.90,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:642,Membrane,,"","",None,"37-57 85-105 108-128 157-177 184-204 229-249",Non Essential,"",AQP8,AQP8,BC040630,Chromosome:16,16p12 178,Protein kinase C alpha type,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P17252,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters","",">Protein kinase C alpha type MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVC CFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVH KQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQ KTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQ EEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSF GKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMM DGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKS LSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFF TRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV",PRKCA,PKC-alpha; PKC-A,672,76765,7.05,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9393,"",,REACT_604-Hemostasis;,"",None,None,Non Essential,"",PRKCA,PRKCA,AF395829,Chromosome:17,17q22-q23.2 179,Glutathione peroxidase 3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P22352,"Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione","",">Glutathione peroxidase 3 MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVA SYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDV NGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMD ILSYMRRQAALGVKRK",GPX3,GSHPx-3; GPx-3; Extracellular glutathione peroxidase; Plasma glutathione peroxidase; GSHPx-P; GPx-P,226,25553,8.29,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4555,Secreted,,"","",1-20,None,Non Essential,"",GPX3,GPX3,BC050378,"","" 180,Tubulin gamma-2 chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,Q9NRH3,"Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly","",">Tubulin gamma-2 chain MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLE PRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHS IAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPYQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTAL NRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQ SVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIP WGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFESSCQQFDKLRKRDAFLEQFRKEDMFKDNFDE MDRSREVVQELIDEYHAATQPDYISWGTQEQ",TUBG2,Gamma-2-tubulin,451,51092,5.59,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12419,Cytoplasmic,,"","",None,None,Non Essential,"",TUBG2,TUBG2,BC108739,Chromosome:17,17q21 181,Ig heavy chain V-I region SIE,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P01761,"","",">Ig heavy chain V-I region SIE QVQLVQSGAEVKKPGSSVRVTCKTSGGTFSGYTISWVRQAPGRGLEWVGSPAKWTDPFQGVYIKWERVTV SLKPSFNQAYMELVNLFNEDGAVYYCAREWKGQVNVNPFDYWGQGVLVTVSSGS","","",124,13733,9.08,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 182,Sodium/potassium-transporting ATPase subunit beta-3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P54709,"This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known","",">Sodium/potassium-transporting ATPase subunit beta-3 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWVMLQTLNDEVP KYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLEEQKNLTVCPDGALFEQKGPV YVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIGLKPEGVPRIDCVSKNEDIPNVAVYPHNGMI DLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA",ATP1B3,Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3; CD298 antigen,279,31513,8.52,">>> Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: sodium:potassium-exchanging ATPase activity || >>> Process: sodium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport || >>> Component: cell Component: membrane","",PF00287:Na_K-ATPase,HGNC:806,Membrane,,"","",None,36-56,Non Essential,"",ATP1B3,ATP1B3,BC011835,"","" 183,Glutamate [NMDA] receptor subunit epsilon-2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,Q13224,NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine,"",">Glutamate [NMDA] receptor subunit epsilon-2 MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVEL VAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDES SMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLD DGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISV SYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLS FSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKI NGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWV MMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKI MVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYA EMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDS GWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMAN LSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNV YQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYS GHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHK RYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVV SGVPAPWEKNLTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRF MDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHG SKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPARFQKDICIGNQSNPCVPNNKNPRAFNGSSN GHVYEKLSSIESDV",GRIN2B,N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; hNR3; NR3,1484,166369,6.92,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00060:Lig_chan,HGNC:4586,Cell membrane,,"","",1-26,"558-578 635-655 818-838",Non Essential,"",GRIN2B,GRIN2B,U28862,Chromosome:12,12p12 184,Cytochrome P450 19A1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P11511,Catalyzes the formation of aromatic C18 estrogens from C19 androgens,"",">Cytochrome P450 19A1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGI GSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPEL WKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDE SAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFAT ELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDI QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEM IFTPRNSDRCLEH",CYP19A1,CYPXIX; Aromatase; Estrogen synthetase; P-450AROM,503,57884,7.56,">>> Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2594,Membrane,,"","",None,None,Non Essential,"",CYP19A1,CYP19A1,M28420,Chromosome:15,15q21.1 185,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,O14983,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction,"",">Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRILLLAAC ISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRI KARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNMLFS GTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFN DPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALC NDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRD RKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLR CLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKG TAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAM TGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVG EVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAI GGYVGAATVGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIEMC NALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWLMVLKISLPVIGL DEILKFVARNYLEDPEDERRK",ATP2A1,"SERCA1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; SR Ca(2+)-ATPase 1; Endoplasmic reticulum class 1/2 Ca(2+) ATPase",1001,110254,4.80,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: hydrogen transport Process: proton transport Process: metabolism Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:811,Endoplasmic reticulum membrane,,"","",None,"49-69 90-110 254-273 296-313 758-777 788-808 829-851 898-917 931-949 965-985",Non Essential,1XP5,ATP2A1,ATP2A1,U96781,Chromosome:16,16p12.1 186,Calcium-transporting ATPase type 2C member 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P98194,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium,"",">Calcium-transporting ATPase type 2C member 1 MKVARFQKIPNGENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEP LWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECH CVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDL ASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGII MLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSD KTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNT LMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYC TTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLI ASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIK SLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK NFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSI LTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCS NRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVERSREKIQKHVS STSSSFLEV",ATP2C1,ATPase 2C1; ATP-dependent Ca(2+) pump PMR1,919,100579,6.72,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity || >>> Process: metabolism Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport Process: di-, tri-valent inorganic cation transport Process: calcium ion transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:13211,Golgi apparatus membrane,,"","",None,"71-91 105-123 263-282 295-312 700-719 730-750 771-793 809-828 842-860 876-896",Non Essential,"",ATP2C1,ATP2C1,AJ010953,"","" 187,Acyl-CoA-binding protein,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P07108,Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor,"",">Acyl-CoA-binding protein MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDA MKAYINKVEELKKKYGI",DBI,ACBP; Diazepam-binding inhibitor; DBI; Endozepine; EP,87,10044,6.54,">>> Function: binding Function: lipid binding Function: fatty acid binding Function: acyl-CoA binding || >>> Process: Not Available || >>> Component: Not Available","",PF00887:ACBP,HGNC:2690,"",,"","",None,None,Non Essential,1NVL,DBI,DBI,BC062996,"","" 188,Ubiquitin,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P62988,"Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair","",">Ubiquitin MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV LRLRGG",RPS27A,"",76,8565,7.54,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification || >>> Component: Not Available","",PF00240:ubiquitin,HGNC:10417,Cytoplasm. Nucleus,,"","",None,None,Non Essential,1V81,RPS27A,RPS27A,M10939,"","" 189,Gamma-aminobutyric acid receptor subunit delta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,O14764,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit delta MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIGGPPVNVALAL EVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVE NKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQ LAQFTITSYRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARV SLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRP RAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLR PIDADTIDIYARAVFPAAFAAVNVIYWAAYAM",GABRD,GABA(A) receptor subunit delta,452,50709,8.73,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4084,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-16,"249-271 275-297 309-331 430-452",Non Essential,"",GABRD,GABRD,BC033801,"","" 190,Hemoglobin subunit theta-1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P09105,"","",">Hemoglobin subunit theta-1 MALSAEDRALVRALWKKLGSNVGVYTTEALERTFLAFPATKTYFSHLDLSPGSSQVRAHGQKVADALSLA VERLDDLPHALSALSHLHACQLRVDPASFQLLGHCLLVTLARHYPGDFSPALQASLDKFLSHVISALVSE YR",HBQ1,Hemoglobin theta-1 chain; Theta-1-globin,142,15508,7.74,">>> Function: oxygen binding Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: physiological process Process: cellular physiological process Process: transport Process: gas transport Process: oxygen transport || >>> Component: protein complex Component: hemoglobin complex","",PF00042:Globin,HGNC:4833,"",,"","",None,None,Non Essential,"",HBQ1,HBQ1,M91453,Chromosome:16,16p13.3 191,Sodium/potassium-transporting ATPase gamma chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:45 UTC,P54710,May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase,"",">Sodium/potassium-transporting ATPase gamma chain MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP",FXYD2,Sodium pump gamma chain; Na(+)/K(+) ATPase subunit gamma; FXYD domain-containing ion transport regulator 2,66,7283,8.47,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF02038:ATP1G1_PLM_MAT8,HGNC:4026,Membrane,,"","",None,29-46,Non Essential,"",FXYD2,FXYD2,BC005302,Chromosome:11,11q23 192,"Cytochrome c oxidase subunit 7B, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P24311,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase polypeptide 7B, mitochondrial MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCIVTWTYVATQVGIEWNLSPVG RVTPKEWRNQ",COX7B,Cytochrome c oxidase polypeptide VIIb,80,9161,10.87,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane Component: organelle membrane Component: organelle inner membrane Component: mitochondrial inner membrane Component: mitochondrial electron transport chain","",PF05392:COX7B,HGNC:2291,Mitochondrion inner membrane (By similarity),"","","",None,33-59,Non Essential,"",COX7B,COX7B,BC018386,"","" 193,Gamma-aminobutyric-acid receptor subunit beta-3,2009-04-08 04:35:12 UTC,2009-07-22 22:35:21 UTC,P28472,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit beta-3 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIA SIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQ FSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAK NDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN",GABRB3,GABA(A) receptor subunit beta-3,473,54116,9.41,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4083,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-25,"246-267 271-293 305-327 451-472",Non Essential,"",GABRB3,GABRB3,L04311,Chromosome:15,15q11.2-q12 194,Ig kappa chain V-I region Lay,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P01605,"","",">Ig kappa chain V-I region Lay DIQMTQSPSSLSVSVGDRVTITCQASQNVNAYLNWYQQKPGLAPKLLIYGASTREAGVPSRFSGSGSGTD FTFTISSLQPEDIATYYCQQYNNWPPTFGQGTKVEVKR","","",108,11834,8.18,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 195,Caspase-1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P29466,"Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis","",">Caspase-1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQ ICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEE AQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASD MTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI GRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH",CASP1,CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; IL-1 beta-converting enzyme; ICE; p45; Contains: RecName: Caspase-1 subunit p20; Contains: RecName: Caspase-1 subunit p10,404,45159,5.71,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: cysteine-type endopeptidase activity Function: caspase activity Function: binding Function: protein binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis Process: regulation of biological process Process: regulation of physiological process Process: regulation of cellular physiological process Process: regulation of programmed cell death Process: regulation of apoptosis || >>> Component: cell Component: intracellular","","PF00619:CARD PF00656:Peptidase_C14",HGNC:1499,Cytoplasm,,"","",None,None,Non Essential,1IBC,CASP1,CASP1,BC062327,Chromosome:11,11q23 196,Gamma-aminobutyric acid receptor subunit theta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,Q9UN88,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit theta MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQKILDRVLSRY DVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYETTLNLTLDYRMHEKLWV PDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVED IILFWDDNGNAIHMTEELHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTT ITSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYIN YLFYSRGPRRQPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTST SEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIFPTEIRNRVEAHG HGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDKSDCLAIKEQFKCDTNSTWGL NDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYH MY",GABRQ,GABA(A) receptor subunit theta,632,72022,5.76,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:14454,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-21,"269-289 327-347 612-632",Non Essential,"",GABRQ,GABRQ,AF144648,"","" 197,Mitogen-activated protein kinase 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P28482,"Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2","",">Mitogen-activated protein kinase 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLR EIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYI HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSID IWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFP NADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEE TARFQPGYRS",MAPK1,Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1,360,41390,6.99,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6871,"",,"","",None,None,Non Essential,4ERK,MAPK1,MAPK1,BC017832,Chromosome:22,22q11.2|22q11.21 198,Mitogen-activated protein kinase 10,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P53779,"Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity (By similarity)","",">Mitogen-activated protein kinase 10 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPI GSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQ DVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV DDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR",MAPK10,Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; MAP kinase p49 3F12,464,52586,6.78,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6872,Cytoplasm,,"","",None,None,Non Essential,1JNK,MAPK10,MAPK10,BC035057,"","" 199,Interleukin-1 beta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P01584,"Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells","",">Interleukin-1 beta MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVA MDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPY ELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKK MEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS",IL1B,IL-1 beta; Catabolin,269,30748,4.45,">>> Function: cytokine activity Function: interleukin-1 receptor binding Function: signal transducer activity Function: receptor binding Function: growth factor activity || >>> Process: response to stimulus Process: response to biotic stimulus Process: defense response Process: immune response Process: inflammatory response || >>> Component: extracellular region","","PF00340:IL1 PF02394:IL1_propep",HGNC:5992,Secreted,,"","",None,None,Non Essential,9ILB,IL1B,IL1B,BC008678,"","" 200,"Cytochrome c oxidase subunit 5B, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P10606,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase subunit 5B, mitochondrial MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKGLDPYNVLAPKGA SGTREDPNLVPSISNKRIVGCICEEDNTSVVWFWLHKGEAQRCPRCGAHYKLVPQQLAH",COX5B,Cytochrome c oxidase polypeptide Vb,129,13696,9.00,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: envelope Component: organelle envelope Component: mitochondrial envelope","",PF01215:COX5B,HGNC:2269,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",COX5B,COX5B,U41284,"","" 201,Aryl hydrocarbon receptor,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P35869,Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues,"",">Aryl hydrocarbon receptor MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVL RLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASS TIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPP ENSPLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEI RTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIV FRLLTKNNRWTWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPF PAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAPFENNFFNESM NECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLYSIMKNLGIDFEDIRHMQNEK FFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQQQQSLALNSSCMVQEHLHLEQQQQHHQKQV VVEPQQQLCQKMKHMQVNGMFENWNSNQFVPFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNF ISCNQPVLPQHSKCTELDYPMGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVS MYQCQPEPQHTHVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFP DLTSSGFL",AHR,Ah receptor; AhR,848,96148,6.34,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: transcription regulator activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of transcription, DNA-dependent Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00010:HLH PF00989:PAS PF08447:PAS_3",HGNC:348,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",AHR,AHR,D38044,"","" 202,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,Q93084,This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction,"",">Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAAL VSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRI RARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFS GTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFA DPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALC NDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRD RKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLR CLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG TAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAM TGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVG EVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAI GVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMC NALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILL DEALKYLSRNHMHACLYPGLLRTVSQAWSRQPLTTSWTPDHTGRNEPEVSAGNRVESPVCTSD",ATP2A3,SERCA3; Calcium pump 3; SR Ca(2+)-ATPase 3,1043,113979,5.26,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: di-, tri-valent inorganic cation transporter activity Function: calcium ion transporter activity Function: calcium-transporting ATPase activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: hydrogen transport Process: proton transport Process: metabolism Process: di-, tri-valent inorganic cation transport Process: calcium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:813,Nucleus membrane,,"","",None,"49-69 90-110 254-273 296-313 758-777 788-808 829-851 898-917 931-949 965-985",Non Essential,"",ATP2A3,ATP2A3,AF458229,Chromosome:17,17p13.3 203,Sodium/potassium-transporting ATPase subunit alpha-4,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,Q13733,"This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients","",">Sodium/potassium-transporting ATPase subunit alpha-4 MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELSTKYSVDLTKG HSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYL SIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKGGDRVPAD LRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIAS LTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTV CLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFT KSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPF NSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGLGERVL GFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITA KAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTS PQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEE GRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKR LPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQ QWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGM DVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY",ATP1A4,Sodium pump subunit alpha-4; Na(+)/K(+) ATPase alpha-4 subunit,1029,114168,6.61,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: monovalent inorganic cation transporter activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: monovalent inorganic cation transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:14073,Membrane,,"","",None,"96-116 140-160 297-316 329-346 779-798 809-829 850-872 925-944 958-976 992-1012",Non Essential,"",ATP1A4,ATP1A4,BC094801,"","" 204,Alcohol dehydrogenase class 4 mu/sigma chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P40394,"Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism","",">Alcohol dehydrogenase class 4 mu/sigma chain MGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEA TGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHF MNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMG CKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALA SCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVL PFKKISEGFELLNSGQSIRTVLTF",ADH7,Alcohol dehydrogenase class IV mu/sigma chain; Retinol dehydrogenase; Gastric alcohol dehydrogenase,374,40006,8.08,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding || >>> Process: Not Available || >>> Component: Not Available",Energy production and conversion,"PF08240:ADH_N PF00107:ADH_zinc_N",HGNC:256,Cytoplasm,,"","",None,None,Non Essential,1D1S,ADH7,ADH7,S77168,"","" 205,Mitogen-activated protein kinase 12,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P53778,Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down- regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation,"",">Mitogen-activated protein kinase 12 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIW SVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLS FKPPRQLGARVSKETPL",MAPK12,Extracellular signal-regulated kinase 6; ERK-6; ERK5; Stress-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; MAP kinase p38 gamma,367,41941,6.33,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6874,Cytoplasm. Mitochondrion,,"","",None,None,Non Essential,1CM8,MAPK12,MAPK12,BC015741,Chromosome:22,22q13.33 206,Delta-aminolevulinic acid dehydratase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P13716,2 5-aminolevulinate = porphobilinogen + 2 H(2)O,"",">Delta-aminolevulinic acid dehydratase MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVE EGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGA FRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRD AAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSG EFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE",ALAD,ALADH; Porphobilinogen synthase,330,36295,6.78,">>> Function: catalytic activity Function: lyase activity Function: carbon-oxygen lyase activity Function: hydro-lyase activity Function: porphobilinogen synthase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: heterocycle metabolism Process: porphyrin metabolism Process: porphyrin biosynthesis Process: heme biosynthesis || >>> Component: Not Available",Coenzyme transport and metabolism,PF00490:ALAD,HGNC:395,"",,"","",None,None,Non Essential,1E51,ALAD,ALAD,AY319481,"","" 207,Superoxide dismutase [Cu-Zn],2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P00441,Destroys radicals which are normally produced within the cells and which are toxic to biological systems,"",">Superoxide dismutase [Cu-Zn] MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR KHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGN AGSRLACGVIGIAQ",SOD1,"",154,15936,6.07,">>> Function: binding Function: ion binding Function: metal ion binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on superoxide radicals as acceptor Function: superoxide dismutase activity Function: copper, zinc superoxide dismutase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: superoxide metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00080:Sod_Cu,HGNC:11179,Cytoplasm,,"","",None,None,Non Essential,1PU0,SOD1,SOD1,X95228,Chromosome:21,21q22.1|21q22.11 208,Estrogen receptor beta,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,Q92731,"Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual","",">Estrogen receptor beta MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPG RQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGP GSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCY EVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHV LISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDH PGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDL LLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ",ESR2,ER-beta; Nuclear receptor subfamily 3 group A member 2,530,59217,8.55,">>> Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:3468,Nucleus,,"","",None,None,Non Essential,1QKM,ESR2,ESR2,BC024181,Chromosome:14,14q23.2 209,Protein kinase C iota type,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P41743,"Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. May play a role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. Functions in both pro- and anti-apoptotic pathways. Functions in the RAC1/ERK signaling required for transformed growth. Plays a role in microtubule dynamics through interaction with RAB2 and GAPDH and recruitment to vesicular tubular clusters (VTCs)","",">Protein kinase C iota type MSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCT VSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFN RRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPY NPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKEL VNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYS AEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGED YGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNK DPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDD IVRKIDQSEFEGFEYINPLLMSAEECV",PRKCI,nPKC-iota; Atypical protein kinase C-lambda/iota; aPKC-lambda/iota; PRKC-lambda/iota,587,67259,5.68,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: signal transducer activity Function: receptor activity Function: phorbol ester receptor activity Function: protein kinase C activity Function: atypical protein kinase C activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00564:PB1 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9404,Cytoplasm. Membrane. Endosome. Nucleus,,"","",None,None,Non Essential,"",PRKCI,PRKCI,BC022016,"","" 210,Leptin,2009-04-08 04:35:12 UTC,2009-06-30 03:51:46 UTC,P41159,May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass,"",">Leptin MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPIL TLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGY STEVVALSRLQGSLQDMLWQLDLSPGC",LEP,Obesity factor; Obese protein,167,18641,6.34,">>> Function: signal transducer activity Function: receptor binding Function: hormone activity || >>> Process: cellular process Process: cell communication Process: signal transduction || >>> Component: extracellular region","",PF02024:Leptin,HGNC:6553,Secreted,,"","",1-21,None,Non Essential,1AX8,LEP,LEP,BC069527,"","" 211,NADH-ubiquinone oxidoreductase chain 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P03886,Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity),"",">NADH-ubiquinone oxidoreductase chain 1 MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEPLKPATSTITL YITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTI SYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSG FNIEYAAGPFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRF RYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT",MT-ND1,NADH dehydrogenase subunit 1,318,35661,6.53,">>> Function: Not Available || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane",Energy production and conversion,PF00146:NADHdh,HGNC:7455,Mitochondrion inner membrane,,"","",None,"2-22 68-88 100-120 146-166 171-191 231-251 253-273 294-314",Non Essential,"",MT-ND1,MT-ND1,M10546,"Chromosome:MT   
HGNC chromosome: mitochondria","" 212,Calcineurin subunit B type 1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P63098,"Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity","",">Calcineurin subunit B type 1 MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEV DFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINA DKDGDGRISFEEFCAVVGGLDIHKKMVVDV",PPP3R1,Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1,170,19300,4.40,">>> Function: binding Function: ion binding Function: cation binding Function: calcium ion binding || >>> Process: Not Available || >>> Component: Not Available","",PF00036:efhand,HGNC:9317,"",,REACT_578-Apoptosis;,"",None,None,Non Essential,1MF8,PPP3R1,PPP3R1,BC027913,"","" 213,Steroid hormone receptor ERR1,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P11474,"Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter","",">Steroid hormone receptor ERR1 MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLV LSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCL RVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLY AMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPL QDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQ LREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEA MMD",ESRRA,"Estrogen-related receptor, alpha; ERR-alpha; Estrogen receptor-like 1; Nuclear receptor subfamily 3 group B member 1",423,45510,6.33,">>> Function: steroid binding Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:3471,Nucleus,,"","",None,None,Non Essential,1XB7,ESRRA,ESRRA,X51416,Chromosome:11,11q13 214,Aquaporin-10,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,Q96PS8,Forms a water channel. Not permeable to urea and glycerol. May contribute to water transport in the upper portion of small intestine,"",">Aquaporin-10 MVFTQAPAEIMGHLRIRSLLARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFLAGSLAVTIAI YVGGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQLLSAFCASGATYVLYHDALQNYTGGNLTVTGPK ETASIFATYPAPYLSLNNGFLDQVLGTGMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLSMGANCG IPLNPARDLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGTATYQLLVALHHPEGPEPAQDLVS AQHKASELETPASAQMLECKL",AQP10,AQP-10; Small intestine aquaporin,301,31764,6.78,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:16029,Membrane,,"","",None,"28-48 53-73 102-122 157-177 188-208",Non Essential,"",AQP10,AQP10,BC074897,"","" 215,Protamine-2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P04554,"Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex","",">Protamine-2 MVRYRVRSLSERSHEVYRQQLHGQEQGHHGQEEQGLSPEHVEVYERTHGQSHYRRRHCSRRRLHRIHRRQ HRSCRRRKRRSCRHRRRHRRGCRTRKRTCRRH",PRM2,Sperm protamine-P2; Sperm histone P2; Contains: RecName: Basic nuclear protein HPI1; Contains: RecName: Basic nuclear protein HPI2; Contains: RecName: Basic nuclear protein HPS1; Contains: RecName: Basic nuclear protein HPS2; Contains: RecName: Sperm histone HP4; Sperm protamine P4; Contains: RecName: Sperm histone HP2; Sperm protamine P2; P2'; Contains: RecName: Sperm histone HP3; Sperm protamine P3; P2'',102,13051,12.39,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: reproduction Process: sexual reproduction Process: gametogenesis Process: male gamete generation Process: spermatogenesis Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome","",PF00841:Protamine_P2,HGNC:9448,Nucleus,,"","",None,None,Non Essential,"",PRM2,PRM2,BC066338,Chromosome:16,16p13.2 216,Tyrosinase,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P14679,"This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone","",">Tyrosinase MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFP FTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTL AKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPW HRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLE EYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASP LTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTA LLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL",TYR,Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB,529,60394,6.05,">>> Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available","",PF00264:Tyrosinase,HGNC:12442,Melanosome membrane,,"","",1-18,477-497,Non Essential,"",TYR,TYR,AY012019,Chromosome:11,11q14-q21 217,Sodium/potassium-transporting ATPase subunit alpha-2,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P50993,"This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients","",">Sodium/potassium-transporting ATPase subunit alpha-2 MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKGLTNQRAQDVL ARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAMEDEPSNDNLYLGVVLAAVVIV TGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCK VDNSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRT PIAMEIEHFIQLITGVAVFLGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMA RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALS RIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPFNSTNKYQLSI HEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYMELGGLGERVLGFCQLNLPSG KFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGI ISEGNETVEDIAARLNIPMSQVNPREAKACVVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVE GCQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLK KSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDK LVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYGQEWTYEQRKV VEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSYCPGMGVALRMYPL KVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY",ATP1A2,Sodium pump subunit alpha-2; Na(+)/K(+) ATPase alpha-2 subunit,1020,112267,5.33,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: monovalent inorganic cation transporter activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: monovalent inorganic cation transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:800,Membrane,,"","",None,"86-106 130-150 287-306 319-336 770-789 800-820 841-863 916-935 949-967 983-1003",Non Essential,1Q3I,ATP1A2,ATP1A2,Y07494,"","" 218,Retinoic acid receptor gamma-1,2009-04-08 04:35:12 UTC,2009-07-22 22:36:36 UTC,P13631,This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression,"",">Retinoic acid receptor gamma MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSS EEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRN RCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKY TTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYT PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKV DKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA",RARG,RAR-gamma; Nuclear receptor subfamily 1 group B member 3,454,50342,7.52,">>> Function: retinoic acid receptor activity Function: signal transducer activity Function: receptor activity Function: ligand-dependent nuclear receptor activity Function: steroid hormone receptor activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF00104:Hormone_recep PF00105:zf-C4",HGNC:9866,Nucleus,,"","",None,None,Non Essential,1EXX,RARG,RARG,AY013704,Chromosome:12,12q13 219,Tubulin beta-2A chain,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,Q13885,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-2A chain MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEP GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK TAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATADEQGEFEEEEGEDEA",TUBB2A,"",445,49908,4.52,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:12412,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB2A,TUBB2A,BC018780,"","" 220,"Cytochrome c oxidase subunit 5A, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P20674,"This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase subunit 5A, mitochondrial MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYFNKPDIDAWEL RKGINTLVTYDMVPEPKIIDAALRACRRLNDFASLVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGIS TPEELGLDKV",COX5A,Cytochrome c oxidase polypeptide Va,150,16774,6.78,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02284:COX5A,HGNC:2267,Mitochondrion inner membrane,,"","",None,None,Non Essential,1V55,COX5A,COX5A,M22760,Chromosome:15,15q24.1 221,"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial",2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P13073,"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport","",">Cytochrome c oxidase subunit 4 isoform 1, mitochondrial MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASW SSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGPLPQSFDKEWVAK QTKRMLDMKVNPIQGLASKWDYEKNEWKK",COX4I1,Cytochrome c oxidase subunit IV isoform 1; COX IV-1; Cytochrome c oxidase polypeptide IV,169,19577,10.12,">>> Function: catalytic activity Function: oxidoreductase activity Function: heme-copper terminal oxidase activity Function: cytochrome-c oxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","",PF02936:COX4,HGNC:2265,Mitochondrion inner membrane,,"","",None,None,Non Essential,1V55,COX4I1,COX4I1,BC021236,Chromosome:16,16q22-qter 222,Haptoglobin,2009-04-08 04:35:12 UTC,2009-06-30 03:51:47 UTC,P00738,"Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes","",">Haptoglobin MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLND KKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGD KLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSE NATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGY VSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDT CYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN",HP,Contains: RecName: Haptoglobin alpha chain; Contains: RecName: Haptoglobin beta chain,406,45206,6.56,">>> Function: catalytic activity Function: hydrolase activity Function: peptidase activity Function: endopeptidase activity Function: serine-type endopeptidase activity Function: binding Function: protein binding Function: hemoglobin binding || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: proteolysis || >>> Component: extracellular region","","PF00084:Sushi PF00089:Trypsin",HGNC:5141,Secreted,,"","",1-18,None,Non Essential,"",HP,HP,X00606,Chromosome:16,16q22.1 223,Tubulin alpha-1B chain,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,P68363,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin alpha-1B chain MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDL EPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHS FGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY DICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTG FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGVDSVEGEGEEEGEEY",TUBA1B,Tubulin alpha-ubiquitous chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1,451,50152,4.70,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","","PF00091:Tubulin PF03953:Tubulin_C",HGNC:18809,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBA1B,TUBA1B,BC071904,Chromosome:12,12q13.12 224,Gamma-aminobutyric-acid receptor subunit beta-1,2009-04-08 04:35:13 UTC,2009-07-22 22:35:21 UTC,P18505,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit beta-1 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVA SIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQ FSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGI TTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANE KNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH",GABRB1,GABA(A) receptor subunit beta-1,474,54235,9.01,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4081,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-25,"246-267 271-293 305-327 452-473",Non Essential,"",GABRB1,GABRB1,S70733,"","" 225,Mitogen-activated protein kinase 7,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q13164,"Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways","",">Mitogen-activated protein kinase 7 MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVS SARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLM ESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTS PAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGT PSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY HDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSR LRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLV LSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQ PACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAP QSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADS ASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP",MAPK7,Extracellular signal-regulated kinase 5; ERK-5; ERK4; Big MAP kinase 1; BMK1 kinase,816,88387,5.68,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6880,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",MAPK7,MAPK7,BC030134,Chromosome:17,17p11.2 226,C-jun-amino-terminal kinase-interacting protein 2,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q13387,"The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins (By similarity)","",">C-jun-amino-terminal kinase-interacting protein 2 MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSLSLGRSEQPHP ICSFQDDFQEFEMIDDNEEEDDEDEEEEEEEEEGDGEGQEGGDPGSEAPAPGPLIPSPSVEEPHKHRPTT LRLTTLGAQDSLNNNGGFDLVRPASWQETALCSPAPEALRELPGPLPATDTGPGGAQSPVRPGCDCEGNR PAEPPAPGGTSPSSDPGIEADLRSRSSGGRGGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSS DGGSSSSGRSSHLTNSIEEASSPASEPEPPREPPRRPAFLPVGPDDTNSEYESGSESEPDLSEDADSPWL LSNLVSRMISEGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVELVDMETLCAPPPP APAAPRPGPAQPGPCLFLSNPTRDTITPLWAAPGRAARPGRACSAACSEEEDEEDDEEEEDAEDSAGSPG GRGTGPSAPRDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDSGGEASEEEAGAALLGGGQVS GDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNGEEREQTHRAVFRFIPRHPDELELDVDDP VLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNG ILCAAMQKIATARKLTVHLRPPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYF GFITKHPLLSRFACHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE",MAPK8IP2,JNK-interacting protein 2; JIP-2; JNK MAP kinase scaffold protein 2; Islet-brain-2; IB-2; Mitogen-activated protein kinase 8-interacting protein 2,824,87975,4.08,"","","PF00640:PID PF00018:SH3_1",HGNC:6883,Cytoplasm,,"","",None,None,Non Essential,"",MAPK8IP2,MAPK8IP2,U79261,Chromosome:22,22q13.33 227,Ribonucleoside-diphosphate reductase subunit M2 B,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q7LG56,Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage,"",">Ribonucleoside-diphosphate reductase subunit M2 B MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQASFWTAEEVD LSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSL LIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKK RGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCI LMKQYIEFVADRLLVELGFSKVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDAD F",RRM2B,TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2,351,40737,4.61,">>> Function: oxidoreductase activity, acting on CH2 groups Function: oxidoreductase activity, acting on CH2 groups, disulfide as acceptor Function: ribonucleoside-diphosphate reductase activity Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleoside diphosphate metabolism Process: deoxyribonucleoside diphosphate metabolism || >>> Component: Not Available",Nucleotide transport and metabolism,PF00268:Ribonuc_red_sm,HGNC:17296,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",RRM2B,RRM2B,BC130628,"","" 228,Tubulin beta-8 chain,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q3ZCM7,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-8 chain MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYVPRAVLVDLEP GTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVVRKEAESCDCLQGFQLTHSLG GGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQLIENADETFCIDNEALYDI CSKTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVAELTQQMFDAKNMMAACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVK TAVCDIPPRGLKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEEEDEEYAEEEVA",TUBB8,"",444,49777,4.52,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C","",Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB8,"",BC101271,"","" 229,"Thioredoxin reductase 2, mitochondrial",2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q9NNW7,Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling,"",">Thioredoxin reductase 2, mitochondrial MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDY VEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLN WGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCA PSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATS VPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHG QEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQV MRTVGIHPTCSEEVVKLRISKRSGLDPTVTGCUG",TXNRD2,Thioredoxin reductase TR3; TR-beta; Selenoprotein Z; SelZ,524,56507,7.55,">>> Function: oxidoreductase activity, acting on NADH or NADPH Function: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor Function: disulfide oxidoreductase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: intracellular Component: cytoplasm",Energy production and conversion,"PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim",HGNC:18155,Mitochondrion,,"","",None,None,Non Essential,"",TXNRD2,TXNRD2,BC007489,Chromosome:22,22q11.21 230,Hypoxia-inducible factor 1 alpha,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q16665,"Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP","",">Hypoxia-inducible factor 1 alpha MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVR KLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCD HEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQC GYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYH ALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDL IFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFT MPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLE MLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTT VPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKT IILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN",HIF1A,HIF-1 alpha; HIF1 alpha; ARNT-interacting protein; Member of PAS protein 1; Basic-helix-loop-helix-PAS protein MOP1,826,92671,4.97,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein histidine kinase activity Function: two-component sensor molecule activity Function: signal transducer activity Function: binding Function: nucleic acid binding Function: DNA binding Function: transcription factor activity Function: transcription regulator activity || >>> Process: two-component signal transduction system (phosphorelay) Process: cellular process Process: cell communication Process: signal transduction Process: regulation of transcription, DNA-dependent Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus",Signal transduction mechanisms,"PF08778:HIF-1a_CTAD PF00010:HLH PF08447:PAS_3",HGNC:4910,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",HIF1A,HIF1A,BC012527,Chromosome:14,14q21-q24 231,NF-kappa-B-repressing factor,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,O15226,"Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription","",">NF-kappa-B-repressing factor MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPVHFVASSSKDE RQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGFILTKDQPVTANMYFDSGNPA PSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTATIWKNLSNPEMTSGSDKINYTYMLTRCIQAC KTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEV RVVRRKFKHTFGEDLVVCQIGMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAI GILNNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQPTYPSVK SSQCHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIA EAVGVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLR KMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNKIAKRDIEQIIRNYARSESHTDLTFSRELTN DERKQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN",NKRF,NFkB-repressing factor; Transcription factor NRF; ITBA4 protein,690,77674,9.09,">>> Function: binding Function: nucleic acid binding Function: RNA binding Function: double-stranded RNA binding || >>> Process: Not Available || >>> Component: cell Component: intracellular","","PF00035:dsrm PF01585:G-patch PF01424:R3H",HGNC:19374,"Nucleus, nucleolus",,"","",None,None,Non Essential,"",NKRF,NKRF,Y07707,"","" 232,Mitogen-activated protein kinase 14,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,Q16539,"Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis","",">Mitogen-activated protein kinase 14 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKY IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVG CIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL AVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVP PPLDQEEMES",MAPK14,Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A,360,41294,5.58,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: receptor signaling protein serine/threonine kinase activity Function: MAP kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:6876,Cytoplasm (By similarity). Nucleus (By similarity),,"","",None,None,Non Essential,1W84,MAPK14,MAPK14,BC031574,"","" 233,Aquaporin-9,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,O43315,"Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea but not to glycerol","",">Aquaporin-9 MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAM AIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVG ENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLN SGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKAE QSEDKPEKYELSVIM",AQP9,AQP-9; Small solute channel 1,295,31401,7.95,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:643,Membrane,,"","",None,"30-50 55-75 111-131 159-179 190-210 246-266",Non Essential,"",AQP9,AQP9,BC026258,Chromosome:15,15q22.1-q22.2 234,Aquaporin-1,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,P29972,"Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient","",">Aquaporin-1 MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHI SGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLG IEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHW IFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK",AQP1,AQP-1; Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule; Urine water channel,269,28526,7.50,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:633,Membrane,,"","",None,"8-36 49-66 77-84 95-115 137-155 167-183 193-200 208-228",Non Essential,1H6I,AQP1,AQP1,AF480415,"","" 235,Aquaporin-7,2009-04-08 04:35:13 UTC,2009-06-30 03:51:48 UTC,O14520,Forms a channel for water and glycerol,"",">Aquaporin-7 MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGV NLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILH FSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILV VIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTI PREPLKLEDSVAYEDHGITVLPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF",AQP7,AQP-7; Aquaporin-7-like; Aquaporin adipose; AQPap,342,37232,9.22,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:640,Membrane,,"","",None,"37-57 66-86 114-134 171-191 197-217 256-276",Non Essential,"",AQP7,AQP7,AL356218,"","" 236,Beta-nerve growth factor,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P01138,Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons,"",">Beta-nerve growth factor MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNI TVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVS VWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKA LTMDGKQAAWRFIRIDTACVCVLSRKAVRRA",NGF,Beta-NGF,241,26959,10.54,">>> Function: signal transducer activity Function: receptor binding Function: growth factor activity || >>> Process: Not Available || >>> Component: Not Available","",PF00243:NGF,HGNC:7808,Secreted,,"","",1-18,None,Non Essential,1SG1,NGF,NGF,X52599,"","" 237,Glutamate [NMDA] receptor subunit 3B,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,O60391,"NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine","",">Glutamate [NMDA] receptor subunit 3B MEFVRALWLGLALALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARAALAPRLPHNL SLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLHFLAAATETPVLSLLRREARAPLG APNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPGGLVALWTSRAGRPPQLVLDLSRRDT GDAGLRARLAPMAAPVGGEAPVPAAVLLGCDIARARRVLEAVPPGPHWLLGTPLPPKALPTAGLPPGLLA LGEVARPPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGR TGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVV TLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYCIDLLERLAED TPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRAR DTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRR TVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWES SAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAI EGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCL GLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEPSGPEVEQQQQ QQDQPTAPEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGPVWLCSYGRPPAARPTGAPQP GELQELERRIEVARERLRQALVRRGQLLAQLGDSARHRPRRLLQARAAPAEAPPHSGRPGSQE",GRIN3B,N-methyl-D-aspartate receptor subtype NR3B; NMDAR3B; NR3B,1043,112993,9.50,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00060:Lig_chan,HGNC:16768,Cell membrane,,"","",1-22,"565-585 649-669 831-851",Non Essential,"",GRIN3B,GRIN3B,BK004079,Chromosome:19,19p13.3 238,Thymosin beta-4,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P62328,Seraspenide inhibits the entry of hematopoeitic pluripotent stem cells into the S-phase (By similarity),"",">Thymosin beta-4 MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES",TMSB4X,T beta-4; Fx; Contains: RecName: Hematopoietic system regulatory peptide; Seraspenide,44,5053,4.72,">>> Function: binding Function: protein binding Function: cytoskeletal protein binding Function: actin binding || >>> Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis || >>> Component: cell Component: intracellular Component: cytoplasm","",PF01290:Thymosin,HGNC:11881,"Cytoplasm, cytoskeleton",,"","",None,None,Non Essential,"",TMSB4X,TMSB4X,X02493,"","" 239,Glutathione peroxidase 7,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q96SL4,2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O,"",">Glutathione peroxidase 7 MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQL QRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEP TWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLILLKREDL",GPX7,CL683,187,20996,8.46,">>> Function: antioxidant activity Function: peroxidase activity Function: glutathione peroxidase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00255:GSHPx,HGNC:4559,Secreted (Potential),,"","",1-19,None,Non Essential,"",GPX7,GPX7,AF091092,"","" 240,Aquaporin-3,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q92482,"Forms a water-specific channel that provide kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. May function as a water and urea exit mechanism in antidiuresis in collecting duct cells. Also slightly permeable to urea and glycerol. May play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity)","",">Aquaporin-3 MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLG ILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGP NGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNS GYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEEN VKLAHVKHKEQI",AQP3,AQP-3,292,31544,7.25,">>> Function: transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Carbohydrate transport and metabolism,PF00230:MIP,HGNC:636,Basolateral cell membrane,,"","",None,"29-49 54-74 110-130 158-178 189-209 245-265",Non Essential,"",AQP3,AQP3,BC013566,"","" 241,Parathyroid hormone/parathyroid hormone-related peptide receptor,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q03431,This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system,"",">Parathyroid hormone/parathyroid hormone-related peptide receptor MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWT SASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNH KGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILA YFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAG CRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTG CWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVH YIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSG SSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKD DGFLNGSCSGLDEEASGPERPPALLQEEWETVM",PTHR1,PTH/PTHrP type I receptor; PTH/PTHr receptor,593,66361,8.05,">>> Function: secretin-like receptor activity Function: parathyroid hormone receptor activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF00002:7tm_2 PF02793:HRM",HGNC:9608,Cell membrane,,"","",1-26,"189-212 220-239 283-306 321-342 362-382 410-428 441-463",Non Essential,1BL1,PTHR1,PTH1R,BC112247,"","" 242,Tubulin beta-3 chain,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q13509,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain","",">Tubulin beta-3 chain MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEP GTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLG GGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDI CFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQ YRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVK VAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEEGEMYEDDEEESEAQGPK",TUBB3,Tubulin beta-III; Tubulin beta-4,450,50433,4.57,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:20772,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB3,TUBB3,BC003021,Chromosome:16,16q24.3 243,Thyrotroph embryonic factor,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q10587,Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3',"",">Thyrotroph embryonic factor MSDAGGGKKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMENPPREARLDKEKGKEKLEEDEAAAAS TMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKESASSSTAS PPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAE EDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVA ELRKEVGKCKTIVSKYETKYGPL",TEF,"",303,33248,5.86,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: regulation of biological process Process: regulation of physiological process Process: regulation of metabolism Process: regulation of cellular metabolism Process: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: regulation of transcription Process: regulation of transcription, DNA-dependent || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","",PF07716:bZIP_2,HGNC:11722,Nucleus,,"","",None,None,Non Essential,"",TEF,TEF,BX537848,Chromosome:22,22q13|22q13.2 244,Gamma-aminobutyric acid receptor subunit pi,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,O00591,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone","",">Gamma-aminobutyric acid receptor subunit pi MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTLDIA SISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLI RLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQY TIERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVS ITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL LFPLIFMLANVFYWAYYMYF",GABRP,GABA(A) receptor subunit pi,440,50641,6.99,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4089,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-16,"243-266 270-292 305-327 417-438",Non Essential,"",GABRP,GABRP,BC074865,"","" 245,Protein kinase C zeta type,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q05513,"PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization","",">Protein kinase C zeta type MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDPCTV SSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNR RAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETD GIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAM KVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPE EHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLT PDDEDAIKRIDQSEFEGFEYINPLLLSTEESV",PRKCZ,nPKC-zeta,592,67661,5.52,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity Function: protein serine/threonine kinase activity Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: signal transducer activity Function: receptor activity Function: phorbol ester receptor activity Function: protein kinase C activity Function: atypical protein kinase C activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available","","PF00130:C1_1 PF00564:PB1 PF00069:Pkinase PF00433:Pkinase_C",HGNC:9412,Cytoplasm. Endosome,,"","",None,None,Non Essential,"",PRKCZ,PRKCZ,BC014270,"","" 246,Gamma-aminobutyric-acid receptor subunit alpha-4,2009-04-08 04:35:13 UTC,2009-07-22 22:35:22 UTC,P48169,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-4 MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGP VTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKS VSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEK SVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWI NKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEK AKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTV NTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM",GABRA4,GABA(A) receptor subunit alpha-4,554,61624,10.02,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4078,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-35,"259-280 285-306 318-340 524-543",Non Essential,"",GABRA4,GABRA4,U20166,"","" 247,Tubulin beta-2B chain,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,Q9BVA1,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)","",">Tubulin beta-2B chain MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEP GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLG GGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK TAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATADEQGEFEEEEGEDEA",TUBB2B,"",445,49954,4.52,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function: pyrophosphatase activity Function: nucleoside-triphosphatase activity Function: GTPase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: guanyl nucleotide binding Function: GTP binding Function: structural molecule activity || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein polymerization Process: physiological process Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: cytoskeleton organization and biogenesis Process: microtubule-based process Process: microtubule-based movement || >>> Component: protein complex Component: cell Component: intracellular Component: cytoplasm Component: organelle Component: non-membrane-bound organelle Component: intracellular non-membrane-bound organelle Component: cytoskeleton Component: microtubule cytoskeleton Component: microtubule","Cell cycle control, cell division, chromosome partitioning","PF00091:Tubulin PF03953:Tubulin_C",HGNC:30829,Cytoplasmic,,"","",None,None,Non Essential,1SA1,TUBB2B,TUBB2B,BC063610,"","" 248,Estrogen sulfotransferase,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P49888,"May control the level of the estrogen receptor by sulfurylating free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated","",">Estrogen sulfotransferase MNSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCK EDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYY FFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFL ERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYE QQMKESTLKFRTEI",SULT1E1,"Sulfotransferase, estrogen-preferring; EST-1",294,35127,6.61,">>> Function: catalytic activity Function: transferase activity Function: transferase activity, transferring sulfur-containing groups Function: sulfotransferase activity || >>> Process: Not Available || >>> Component: Not Available","",PF00685:Sulfotransfer_1,HGNC:11377,Cytoplasm,,"","",None,None,Non Essential,1G3M,SULT1E1,SULT1E1,U55764,"","" 249,Catalase,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P04040,"Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells","",">Catalase MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDEMAHFDRERIP ERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTED GNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHR HMNGYGSHTFKLVNANGEAVYCKFHYKTDQGIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFY IQVMTFNQAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKM LQGRLFAYPDTHRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVKNFTEVHPDYG SHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL",CAT,"",527,59757,7.41,">>> Function: antioxidant activity Function: peroxidase activity Function: catalase activity || >>> Process: oxygen and reactive oxygen species metabolism Process: response to oxidative stress Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00199:Catalase,HGNC:1516,Peroxisome,,"","",None,None,Non Essential,1F4J,CAT,CAT,K02400,Chromosome:11,11p13 250,Serum albumin,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P02768,"Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood","",">Serum albumin MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEV TEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLV RPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELR DEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADD RADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVF LGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEK TPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHK PKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL",ALB,"",609,69367,6.21,">>> Function: transporter activity Function: carrier activity || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: extracellular region Component: extracellular space","",PF00273:Serum_albumin,HGNC:399,Secreted,,REACT_604-Hemostasis;,"",1-18,None,Non Essential,1HA2,ALB,ALB,M13075,"","" 252,Histone H3.1,2009-04-08 04:35:13 UTC,2009-06-30 03:51:49 UTC,P68431,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H3.1 MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQR LVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA",HIST1H3A,H3/a; H3/b; H3/c; H3/d; H3/f; H3/h; H3/i; H3/j; H3/k; H3/l,136,15404,11.71,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:4766,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST1H3A,HIST1H3A,BC127610,"","" 253,Histone H3.2,2009-04-08 04:35:13 UTC,2009-06-30 03:51:50 UTC,Q71DI3,"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","",">Histone H3.2 MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQR LVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA",HIST2H3A,H3/m; H3/o,136,15388,11.83,">>> Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: cellular physiological process Process: cell organization and biogenesis Process: organelle organization and biogenesis Process: chromosome organization and biogenesis Process: chromosome organization and biogenesis (sensu Eukaryota) Process: physiological process Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: protein complex assembly Process: nucleosome assembly || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus Component: protein complex Component: nucleosome",Chromatin structure and dynamics,PF00125:Histone,HGNC:20505,Nucleus,,"","",None,None,Non Essential,1EQZ,HIST2H3A,HIST2H3A,BC130637,"","" 254,Glutamate [NMDA] receptor subunit epsilon-1,2009-04-08 04:35:13 UTC,2009-06-30 03:51:50 UTC,Q12879,NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits,"",">Glutamate [NMDA] receptor subunit epsilon-1 MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVV ALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDP TSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSF EDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVS YDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSF TEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVN NVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVM MFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIM VSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSP WKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNM NSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNMNELQTFVANRQKDNLNNYVF QGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPR YLPEEMAHSDISETSNRATCHREPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTI DGEKEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKH FTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLFS VPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDSY LRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNRRVYKKMPSIESDV",GRIN2A,N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A,1464,165284,7.11,">>> Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: excitatory extracellular ligand-gated ion channel activity Function: glutamate-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: glutamate receptor activity Function: ionotropic glutamate receptor activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane","",PF00060:Lig_chan,HGNC:4585,Cell membrane,,"","",1-22,"556-576 634-654 817-837",Non Essential,"",GRIN2A,GRIN2A,U90277,Chromosome:16,16p13.2 255,Sodium/potassium-transporting ATPase subunit alpha-3,2009-04-08 04:35:13 UTC,2009-06-30 03:51:50 UTC,P13637,"This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients","",">Sodium/potassium-transporting ATPase subunit alpha-3 MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNAL TPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQ EAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTG ESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEH FIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKN LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNR AVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPND NRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFA FDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNET VEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGA IVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL TSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLI SMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHT AFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFC AFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY",ATP1A3,Sodium pump subunit alpha-3; Na(+)/K(+) ATPase alpha-3 subunit; Na(+)/K(+) ATPase alpha(III) subunit,1013,111750,5.02,">>> Function: hydrolase activity Function: hydrolase activity, acting on acid anhydrides Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Function: catalytic activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: monovalent inorganic cation transporter activity Function: transporter activity Function: ion transporter activity Function: cation transporter activity Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism || >>> Process: metabolism Process: monovalent inorganic cation transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: cation transport || >>> Component: intrinsic to membrane Component: integral to membrane Component: cell Component: membrane",Inorganic ion transport and metabolism,"PF00689:Cation_ATPase_C PF00690:Cation_ATPase_N PF00122:E1-E2_ATPase PF00702:Hydrolase",HGNC:801,Membrane,,"","",None,"78-98 122-142 279-298 311-328 763-782 793-813 834-856 909-928 942-960 976-996",Non Essential,"",ATP1A3,ATP1A3,M27577,Chromosome:19,19q13.31 256,Ig kappa chain V-III region POM,2009-04-08 04:35:13 UTC,2009-06-30 03:51:50 UTC,P01624,"","",">Ig kappa chain V-III region POM EIVMTQSPVTLSVSPGERATLSCRASQSISNSYLAWYQQKPSGSPRLLIYGASTRATGIPARFSGSGSGT EFTLTISSLQSEDFAVYYCQQYNNWPPTFGQGTRVEIKR","","",109,11922,9.12,"","",PF07686:V-set,"","",,"","",None,None,Non Essential,"","","","","","" 257,Gamma-aminobutyric-acid receptor subunit alpha-6,2009-04-08 04:35:13 UTC,2009-07-22 22:35:22 UTC,Q16445,"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel","",">Gamma-aminobutyric acid receptor subunit alpha-6 MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPV SDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQ NGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDL IGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTV LTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTIS KATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE",GABRA6,GABA(A) receptor subunit alpha-6,453,51025,8.40,">>> Function: neurotransmitter receptor activity Function: transporter activity Function: ion transporter activity Function: ion channel activity Function: ligand-gated ion channel activity Function: extracellular ligand-gated ion channel activity Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: GABA receptor activity Function: GABA-A receptor activity || >>> Process: cellular process Process: cell communication Process: signal transduction Process: cell surface receptor linked signal transduction Process: G-protein coupled receptor protein signaling pathway Process: gamma-aminobutyric acid signaling pathway Process: anion transport Process: inorganic anion transport Process: chloride transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: postsynaptic membrane Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane","","PF02931:Neur_chan_LBD PF02932:Neur_chan_memb",HGNC:4080,"Cell junction, synapse, postsynaptic cell membrane",,"","",1-19,"243-264 269-290 301-324 420-441",Non Essential,"",GABRA6,GABRA6,BC099641,"","" 265,Sodium channel subunit beta-2,2009-05-01 20:58:19 UTC,2009-06-30 03:51:41 UTC,O60939,"Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity)","",">Sodium channel subunit beta-2 MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQ ECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHG KIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNP DDGAK",SCN2B,"",215,24326,6.35,">>> Function: Not Available || >>> Process: Not Available || >>> Component: cell Component: membrane","",PF07686:V-set,HGNC:10589,Membrane,,"","",1-29,160-180,Non Essential,"",SCN2B,SCN2B,BC036793,Chromosome:11,11q23 266,Sodium channel subunit beta-3,2009-05-01 20:58:59 UTC,2009-06-30 03:51:40 UTC,Q9NY72,Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity),"",">Sodium channel subunit beta-3 MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGK DFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRL IPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSA VPVEE",SCN3B,"",215,24703,4.35,"","",PF07686:V-set,HGNC:20665,Membrane,,"","",1-22,160-180,Non Essential,"",SCN3B,SCN3B,BC126265,Chromosome:11,11q23.3 267,Sodium channel subunit beta-1,2009-05-01 21:00:32 UTC,2009-06-30 03:51:48 UTC,Q07699,"Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons","",">Sodium channel subunit beta-1 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKI LRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVK KIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKEN CTGVQVAE",SCN1B,"",218,24707,4.56,"","",PF00047:ig,HGNC:10586,Membrane,,"","",1-18,161-182,Non Essential,"",SCN1B,SCN1B,BC067122,Chromosome:19,19q13.1 268,Sodium channel subunit beta-4,2009-05-01 21:00:55 UTC,2009-06-30 03:51:49 UTC,Q8IWT1,"Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity)","",">Sodium channel subunit beta-4 MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTY NSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENN LQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDN TENGLPGSKAEEKPPSKV",SCN4B,"",228,24969,7.45,"","",PF07686:V-set,HGNC:10592,Membrane,,"","",1-30,163-183,Non Essential,"",SCN4B,SCN4B,AY149967,Chromosome:11,11q23.3 269,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,2009-05-04 16:51:55 UTC,2009-06-30 03:51:44 UTC,Q9P1Z3 ,Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (By similarity),"",">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKA VEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLD LVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIV RFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPP DCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALI QSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCR GLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSY FGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSE PSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGP LPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGG GGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQL SANM",HCN3,"",774,86033,10.12,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08412:Ion_trans_N",HGNC:19183,Membrane,,"","",None,"98-118 125-145 172-192 202-222 254-274 298-319 330-350",Non Essential,"",HCN3,HCN3,BC000066,"","" 270,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,2009-05-04 16:55:51 UTC,2009-06-30 03:51:49 UTC,O60741,"Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli","",">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGG GGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSD FRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDP KVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQ WEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALF KAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSF HKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSK LRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCR LYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDR EMVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYT TAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKS TQALHNTNLTREVRPFSAWQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVT LFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL",HCN1,Brain cyclic nucleotide-gated channel 1; BCNG-1,890,98930,8.54,">>> Function: voltage-gated ion channel activity Function: voltage-gated potassium channel activity Function: transporter activity Function: ion transporter activity Function: ion channel activity || >>> Process: cation transport Process: monovalent inorganic cation transport Process: potassium ion transport Process: physiological process Process: cellular physiological process Process: transport Process: ion transport || >>> Component: cell Component: membrane",Signal transduction mechanisms,"PF00027:cNMP_binding PF00520:Ion_trans PF08412:Ion_trans_N",HGNC:4845,Membrane,,"","",None,"147-167 174-194 220-240 249-269 301-321 345-366 372-392",Non Essential,1Q3E,HCN1,HCN1,AF064876,"","" 271,DNA repair protein complementing XP-A cells,2009-05-04 17:29:01 UTC,2009-06-30 03:51:46 UTC,P23025,"Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region","",">DNA repair protein complementing XP-A cells MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMANVKAAPKIID TGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLIT KTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQEN REKMKQKKFDKKVKELRRAVRSSVWKRETIVHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM",XPA,Xeroderma pigmentosum group A-complementing protein,273,31368,6.72,">>> Function: binding Function: nucleic acid binding Function: DNA binding Function: damaged DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA repair Process: nucleotide-excision repair || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","","PF05181:XPA_C PF01286:XPA_N",HGNC:12814,Nucleus,,"","",None,None,Non Essential,1XPA,XPA,XPA,U16815,"","" 272,"Alkaline phosphatase, tissue-nonspecific isozyme",2009-05-04 22:15:10 UTC,2009-06-30 03:51:45 UTC,P05186,This isozyme may play a role in skeletal mineralization,"",">Alkaline phosphatase, tissue-nonspecific isozyme MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDP HNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACI GANLGHCAPASSAGSLAAGPLLLALALYPLSVLF",ALPL,AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme,524,57305,6.66,">>> Function: Not Available || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00245:Alk_phosphatase,HGNC:438,Cell membrane,,"","",1-17,None,Non Essential,"",ALPL,ALPL,BC126165,"","" 273,"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial",2009-05-05 15:57:35 UTC,2009-06-30 03:51:35 UTC,P08559,"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)","",">Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQT VRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTG RKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNM AALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPI LMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAA QFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS",PDHA1,PDHE1-A type I,390,43296,8.14,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Energy production and conversion,PF00676:E1_dh,HGNC:8806,Mitochondrion matrix,,"","",None,None,Non Essential,1NI4,PDHA1,PDHA1,AF125088,"","" 274,"Pyruvate dehydrogenase protein X component, mitochondrial",2009-05-05 15:58:40 UTC,2009-06-30 03:51:39 UTC,O00330,Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex,"",">Pyruvate dehydrogenase protein X component, mitochondrial MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKILMPSLSPTMEE GNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKH VEIPKDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTATGPRGI FTKEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFTEIPA SNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQDLVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSW DGEGPKQLPFIDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL GMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSF KANLENPIRLA",PDHX,Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; Lipoyl-containing pyruvate dehydrogenase complex component X; E3-binding protein; E3BP; proX,501,54123,9.09,">>> Function: binding Function: protein binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Energy production and conversion,"PF00198:2-oxoacid_dh PF00364:Biotin_lipoyl PF02817:E3_binding",HGNC:21350,Mitochondrion matrix,,"","",None,None,Non Essential,"",PDHX,PDHX,U79296,Chromosome:11,11p13 275,"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial",2009-05-05 15:59:07 UTC,2009-06-30 03:51:38 UTC,P11177,"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)","",">Pyruvate dehydrogenase E1 component subunit beta, mitochondrial MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVS RGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPV PIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPF EFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIE ASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDII FAIKKTLNI",PDHB,PDHE1-B,359,39234,6.63,"",Energy production and conversion,"PF02779:Transket_pyr PF02780:Transketolase_C",HGNC:8808,Mitochondrion matrix,,"","",None,None,Non Essential,1NI4,PDHB,PDHB,X57778,"","" 276,"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial",2009-05-05 16:00:38 UTC,2009-06-30 03:51:49 UTC,P10515,"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)","",">Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial MWRVCARRAQNVAPWAGLEARWTALQEVPGTPRVTSRSGPAPARRNSVTTGYGGVRALCGWTPSSGATPR NRLLLQLLGSPGRRYYSLPPHQKVPLPSLSPTMQAGTIARWEKKEGDKINEGDLIAEVETDKATVGFESL EECYMAKILVAEGTRDVPIGAIICITVGKPEDIEAFKNYTLDSSAAPTPQAAPAPTPAATASPPTPSAQA PGSSYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEG TRDVPLGTPLCIIVEKEADISAFADYRPTEVTDLKPQVPPPTPPPVAAVPPTPQPLAPTPSAPCPATPAG PKGRVFVSPLAKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPPTGPGMAPVPTGVF TDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEGRSKISVNDFIIKASALACLK VPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQG GTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQ WLAEFRKYLEKPITMLL",DLAT,Pyruvate dehydrogenase complex E2 subunit; PDC-E2; PDCE2; E2; Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; M2 antigen complex 70 kDa subunit,647,68997,7.94,">>> Function: binding Function: protein binding Function: acetyltransferase activity Function: S-acetyltransferase activity Function: dihydrolipoyllysine-residue acetyltransferase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring acyl groups Function: transferase activity, transferring groups other than amino-acyl groups Function: acyltransferase activity || >>> Process: cellular metabolism Process: alcohol metabolism Process: monosaccharide metabolism Process: hexose metabolism Process: glucose metabolism Process: glucose catabolism Process: glycolysis Process: physiological process Process: metabolism || >>> Component: protein complex Component: pyruvate dehydrogenase complex",Energy production and conversion,"PF00198:2-oxoacid_dh PF00364:Biotin_lipoyl PF02817:E3_binding",HGNC:2896,Mitochondrion matrix,,"","",None,None,Non Essential,1FYC,DLAT,DLAT,Y00978,Chromosome:11,11q23.1 277,Tyrosine 3-monooxygenase,2009-05-05 17:41:42 UTC,2009-06-30 03:51:38 UTC,P07101,Plays an important role in the physiology of adrenergic neurons,"",">Tyrosine 3-monooxygenase MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTPRSPRFIGRRQ SLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAK IHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCHHL VTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACG EHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASS PMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKF DPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG",TH,Tyrosine 3-hydroxylase; TH,528,58525,6.25,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Function: tyrosine 3-monooxygenase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: amino acid derivative metabolism Process: biogenic amine metabolism Process: catecholamine metabolism Process: catecholamine biosynthesis Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism Process: amino acid metabolism Process: aromatic amino acid family metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00351:Biopterin_H,HGNC:11782,"",,"","",None,None,Non Essential,1TOH,TH,TH,M20911,Chromosome:11,11p15.5 278,Aromatic-L-amino-acid decarboxylase,2009-05-05 17:42:31 UTC,2009-06-30 03:51:46 UTC,P20711,"Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine","",">Aromatic-L-amino-acid decarboxylase MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTH WHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEG GGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIP SDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFI CPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQ IPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE",DDC,AADC; DOPA decarboxylase; DDC,480,53895,7.21,">>> Function: catalytic activity Function: lyase activity Function: carbon-carbon lyase activity Function: carboxy-lyase activity || >>> Process: amino acid metabolism Process: physiological process Process: metabolism Process: cellular metabolism Process: amino acid and derivative metabolism || >>> Component: Not Available",Amino acid transport and metabolism,PF00282:Pyridoxal_deC,HGNC:2719,"",,"","",None,None,Non Essential,1JS3,DDC,DDC,S46516,"","" 279,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial",2009-05-05 19:48:02 UTC,2009-06-30 03:51:47 UTC,Q15120,"Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism","",">[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDN LLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFD PFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQ YYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKED LSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGV GTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ",PDK3,Pyruvate dehydrogenase kinase isoform 3,406,46939,8.61,">>> Function: kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: physiological process Process: metabolism Process: cellular metabolism Process: phosphorus metabolism Process: phosphate metabolism Process: phosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF02518:HATPase_c,HGNC:8811,Mitochondrion matrix,,"","",None,None,Non Essential,"",PDK3,PDK3,BC015948,"","" 280,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial",2009-05-05 19:48:27 UTC,2009-06-30 03:51:37 UTC,Q16654,"Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism","",">[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILK EIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIE YKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFEC SRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIV VLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNL YSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM",PDK4,Pyruvate dehydrogenase kinase isoform 4,411,46470,6.65,">>> Function: kinase activity Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding || >>> Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation Process: physiological process Process: metabolism Process: cellular metabolism Process: phosphorus metabolism Process: phosphate metabolism Process: phosphorylation || >>> Component: Not Available",Signal transduction mechanisms,PF02518:HATPase_c,HGNC:8812,Mitochondrion matrix,,"","",None,None,Non Essential,"",PDK4,PDK4,BC040239,"","" 281,DNA (cytosine-5)-methyltransferase 1,2009-05-06 15:10:31 UTC,2009-06-30 03:51:34 UTC,P26358,Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2,"",">DNA (cytosine-5)-methyltransferase 1 MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRK EELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRR SKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSR ERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDE KDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHP PKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLC PIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMD PSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQ VESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLVYQIFDT FFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEAD DDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDS SKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPS ENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQKEIPRV LEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYI KGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAV VDFKAVQGRCTVEYGEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKP KSQACEPSEPEIEIKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTED CNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRP RFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEP LHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQL RGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSG ALRGVCSCVEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVL HPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKE EEAAKD",DNMT1,Dnmt1; MCMT; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; CXXC-type zinc finger protein 9,1616,183167,7.81,">>> Function: ion binding Function: cation binding Function: transition metal ion binding Function: zinc ion binding Function: protein binding Function: transcription factor binding Function: binding Function: nucleic acid binding Function: DNA binding || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: DNA metabolism Process: DNA modification Process: DNA alkylation Process: DNA methylation || >>> Component: organelle Component: membrane-bound organelle Component: intracellular membrane-bound organelle Component: nucleus","Replication, recombination and repair","PF01426:BAH PF06464:DMAP_binding PF00145:DNA_methylase PF02008:zf-CXXC",HGNC:2976,Nucleus,,"","",None,None,Non Essential,"",DNMT1,DNMT1,AF169120,Chromosome:19,19p13.2 282,Cytochrome P450 1A2,2009-05-06 16:15:03 UTC,2009-06-30 03:51:36 UTC,P05177,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen","",">Cytochrome P450 1A2 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQ RYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLA QNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFP ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSV RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTV IGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVD LTPIYGLTMKHARCEHVQARRFSIN",CYP1A2,CYPIA2; P450-P3; P(3)450; P450 4,515,58295,9.43,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2596,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP1A2,CYP1A2,M55053,Chromosome:15,15q24.1 283,Cytochrome P450 3A4,2009-05-06 16:15:56 UTC,2009-06-30 03:51:38 UTC,P08684,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide","",">Cytochrome P450 3A4 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGK VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKL LRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTV LQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVV LKVESRDGTVSGA",CYP3A4,Quinine 3-monooxygenase; CYPIIIA4; Nifedipine oxidase; Cytochrome P450 3A3; CYPIIIA3; HLp; Taurochenodeoxycholate 6-alpha-hydroxylase; NF-25; P450-PCN1,503,57344,8.25,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2637,Endoplasmic reticulum membrane,,"","",None,2-22,Non Essential,1TQN,CYP3A4,CYP3A4,AF209389,"","" 284,Cytochrome P450 3A5,2009-05-06 16:16:11 UTC,2009-06-30 03:51:41 UTC,P20815,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics","",">Cytochrome P450 3A5 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGK MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKF LKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQN SKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAV VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL KVDSRDGTLSGE",CYP3A5,CYPIIIA5; P450-PCN3; HLp2,502,57109,9.09,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2638,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP3A5,CYP3A5,S74700,"","" 285,Cytochrome P450 3A43,2009-05-06 16:16:30 UTC,2009-06-30 03:51:47 UTC,Q9HB55,Exhibits low testosterone 6-beta-hydroxylase activity,"",">Cytochrome P450 3A43 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGE MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSV KFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL LKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDAL VQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIV LKVHLRDGITSGP",CYP3A43,"",503,57671,8.25,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:17450,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP3A43,CYP3A43,AY390426,"","" 286,Cytochrome P450 3A7,2009-05-06 16:16:45 UTC,2009-06-30 03:51:49 UTC,P24462,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics","",">Cytochrome P450 3A7 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRK VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSG KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKL LRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQN SKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTV LQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWREPEKFLPERFS KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIV LKAESRDETVSGA",CYP3A7,CYPIIIA7; P450-HFLA,503,57526,9.59,">>> Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Function: tetrapyrrole binding Function: heme binding Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: catalytic activity Function: oxidoreductase activity Function: monooxygenase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Secondary metabolites biosynthesis, transport and catabolism",PF00067:p450,HGNC:2640,Endoplasmic reticulum membrane,,"","",None,None,Non Essential,"",CYP3A7,CYP3A7,BC067436,"","" 287,"Alkaline phosphatase, placental type",2009-05-06 16:34:31 UTC,2009-06-30 03:51:43 UTC,P05187,A phosphate monoester + H(2)O = an alcohol + phosphate,"",">Alkaline phosphatase, placental type MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVST VTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARF NQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIAT QLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASL DPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRAL TETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG YVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACL EPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP",ALPP,PLAP-1; Alkaline phosphatase Regan isozyme,535,57954,6.24,">>> Function: Not Available || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00245:Alk_phosphatase,HGNC:439,Cell membrane,,"","",1-22,513-529,Non Essential,1EW2,ALPP,ALPP,M12551,"","" 288,Intestinal alkaline phosphatase,2009-05-06 16:34:59 UTC,2009-06-30 03:51:48 UTC,P09923,A phosphate monoester + H(2)O = an alcohol + phosphate,"",">Intestinal alkaline phosphatase MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTA TRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQC NTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLI SNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQS VTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEA VMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVF NSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPY TACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP",ALPI,IAP,528,56813,5.70,">>> Function: Not Available || >>> Process: physiological process Process: metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00245:Alk_phosphatase,HGNC:437,Cell membrane,,"","",1-19,None,Non Essential,"",ALPI,ALPI,M19161,"","" 289,Parathyroid hormone,2009-05-06 17:04:57 UTC,2009-06-30 03:51:38 UTC,P01270,PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion,"",">Parathyroid hormone MIPAKDMAKVMIVMLAICFLTKSDGKSVKKRSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGA PLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ",PTH,PTH; Parathyrin; Parathormone,115,12861,10.49,">>> Function: signal transducer activity Function: receptor binding Function: hormone activity || >>> Process: Not Available || >>> Component: extracellular region","",PF01279:Parathyroid,HGNC:9606,Secreted,,"","",1-25,None,Non Essential,1BWX,PTH,PTH,BC096145,Chromosome:11,11p15.3-p15.1 290,Tuberoinfundibular peptide of 39 residues,2009-05-06 17:05:38 UTC,2009-06-30 03:51:49 UTC,Q96A98,"Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits","",">Tuberoinfundibular peptide of 39 residues METRQVSRSPRVRLLLLLLLLLVVPWGVRTASGVALPPVGVLSLRPPGRAWADPATPRPRRSLALADDAA FRERARLLAALERRHWLNSYMHKLLVLDAP",PTH2,TIP39; Parathyroid hormone 2,100,11202,12.33,"","","",HGNC:30828,Secreted,,"","",1-30,None,Non Essential,"",PTH2,PTH2,AY048588,Chromosome:19,19q13.33 291,Parathyroid hormone 2 receptor,2009-05-06 17:06:05 UTC,2009-06-30 03:51:45 UTC,P49190,This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity),"",">Parathyroid hormone 2 receptor MAGLGASLHVWGWLMLGSCLLARAQLDSDGTITIEEQIVLVLKAKVQCELNITAQLQEGEGNCFPEWDGL ICWPRGTVGKISAVPCPPYIYDFNHKGVAFRHCNPNGTWDFMHSLNKTWANYSDCLRFLQPDISIGKQEF FERLYVMYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHMHLFVSFMLRATSIFVKDRVVHAHIGVKEL ESLIMQDDPQNSIEATSVDKSQYIGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVAFFSDTKYLWGFI LIGWGFPAAFVAAWAVARATLADARCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAV GHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFTGLGWEIRMHCELFFNSFQGFFVSIIYCYCNGEV QAEVKKMWSRWNLSVDWKRTPPCGSRRCGSVLTTVTHSTSSQSQVAASTRMVLISGKAAKIASRQPDSHI TLPGYVWSNSEQDCLPHSFHEETKEDSGRQGDDILMEKPSRPMESNPDTEGCQGETEDVL",PTH2R,PTH2 receptor,550,62236,7.09,">>> Function: signal transducer activity Function: receptor activity Function: transmembrane receptor activity Function: G-protein coupled receptor activity || >>> Process: Not Available || >>> Component: cell Component: membrane","","PF00002:7tm_2 PF02793:HRM",HGNC:9609,Cell membrane,,"","",1-24,"146-169 177-196 238-260 276-297 317-337 365-383 395-417",Non Essential,"",PTH2R,PTH2R,U47129,"","" 293,Sodium-dependent phosphate transporter 1,2009-05-06 17:35:38 UTC,2009-06-30 03:51:41 UTC,Q8WUM9,"Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV)","",">Sodium-dependent phosphate transporter 1 MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFE TVGSVLLGAKVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGF SLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADPVPNGLRALPVFYACTVGINL FSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLKE DHEETKLSVGDIENKHPVSEVGPATVPLQAVVEERTVSFKLGDLEEAPERERLPSVDLKEETSIDSTVNG AVQLPNGNLVQFSQAVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTS YTMAICGMPLDSFRAKEGEQKGEEMEKLTWPNADSKKRIRMDSYTSYCNAVSDLHSASEIDMSVKAEMGL GDRKGSNGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYDTGDVSSKVAT PIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSV VSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVILRM",SLC20A1,Solute carrier family 20 member 1; Phosphate transporter 1; PiT-1; Gibbon ape leukemia virus receptor 1; GLVR-1; Leukemia virus receptor 1 homolog,679,73700,7.08,">>> Function: transporter activity Function: ion transporter activity Function: anion transporter activity Function: inorganic anion transporter activity Function: phosphate transporter activity Function: inorganic phosphate transporter activity || >>> Process: physiological process Process: cellular physiological process Process: transport Process: ion transport Process: anion transport Process: inorganic anion transport Process: phosphate transport || >>> Component: cell Component: membrane",Inorganic ion transport and metabolism,PF01384:PHO4,HGNC:10946,Membrane,,"","",None,"21-41 62-82 100-120 158-178 203-223 230-250 511-531 558-578 600-620 650-670",Non Essential,"",SLC20A1,SLC20A1,AF102063,"","" 294,Apolipoprotein D,2009-05-06 19:12:37 UTC,2009-06-30 03:51:50 UTC,P05090,APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts,"",">Apolipoprotein D MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTFENGRCIQANYSLME NGKIKVLNQELRADGTVNQIEGEATPVNLTEPAKLEVKFSWFMPSAPYWILATDYENYALVYSCTCIIQL FHVDFAWILARNPNLPPETVDSLKNILTSNNIDVKKMTVTDQVNCPKLS",APOD,Apo-D; ApoD,189,21276,4.79,">>> Function: isoprenoid binding Function: retinoid binding Function: transporter activity Function: binding Function: lipid binding || >>> Process: physiological process Process: cellular physiological process Process: transport || >>> Component: Not Available",Cell wall/membrane/envelope biogenesis,PF00061:Lipocalin,HGNC:612,Secreted,,"","",1-20,None,Non Essential,"",APOD,APOD,S80440,"","" 295,"Superoxide dismutase [Mn], mitochondrial",2009-05-06 21:00:26 UTC,2009-06-30 03:51:42 UTC,P04179,Destroys radicals which are normally produced within the cells and which are toxic to biological systems,"",">Superoxide dismutase [Mn], mitochondrial MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQ EALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASV GVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINW ENVTERYMACKK",SOD2,"",222,24722,8.45,">>> Function: binding Function: ion binding Function: metal ion binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on superoxide radicals as acceptor Function: superoxide dismutase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: superoxide metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,"PF02777:Sod_Fe_C PF00081:Sod_Fe_N",HGNC:11180,Mitochondrion matrix,,"","",None,None,Non Essential,1LUV,SOD2,SOD2,BC012423,"","" 296,Extracellular superoxide dismutase [Cu-Zn],2009-05-06 21:00:49 UTC,2009-06-30 03:51:41 UTC,P08294,Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen,"",">Extracellular superoxide dismutase [Cu-Zn] MLALLCSCLLLAAGASDAWTGEDSAEPNSDSAEWIRDMYAKVTEIWQEVMQRRDDDGALHAACQVQPSAT LDAAQPRVTGVVLFRQLAPRAKLDAFFALEGFPTEPNSSSRAIHVHQFGDLSQGCESTGPHYNPLAVPHP QHPGDFGNFAVRDGSLWRYRAGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVV GVCGPGLWERQAREHSERKKRRRESECKAA",SOD3,EC-SOD,240,25851,6.59,">>> Function: binding Function: ion binding Function: metal ion binding Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on superoxide radicals as acceptor Function: superoxide dismutase activity Function: copper, zinc superoxide dismutase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: oxygen and reactive oxygen species metabolism Process: superoxide metabolism || >>> Component: Not Available",Inorganic ion transport and metabolism,PF00080:Sod_Cu,HGNC:11181,"Secreted, extracellular space",,"","",1-18,None,Non Essential,"",SOD3,SOD3,BC014418,"","" 297,Xanthine dehydrogenase/oxidase,2009-05-06 21:15:11 UTC,2009-06-30 03:51:39 UTC,P47989,This enzyme can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups,"",">Xanthine dehydrogenase/oxidase MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSA NACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIE NAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCCMNQKKDHSVSLSPSLFKPEEFTPLDPTQEP IFPPELLRLKDTPRKQLRFEGERVTWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVC PAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGG NIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSA FKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGL AEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLDPTFASATLLFQKDPPADVQL FQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVP GFVCFISADDVPGSNITGICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIE DAIKNNSFYGPELKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNT MKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGR HPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNT AFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEGFTLPRCWEECLASSQYHA RKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQV ASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTA AYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPA IDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAV GEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPATPEKIRNACVDKFTTLCVTGVPENCKPWS VRV",XDH,Xanthine dehydrogenase; XD; Xanthine oxidase; XO; Xanthine oxidoreductase,1333,146426,7.70,">>> Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: transporter activity Function: electron transporter activity Function: binding Function: ion binding Function: metal ion binding Function: catalytic activity Function: oxidoreductase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Nucleotide transport and metabolism,"PF01315:Ald_Xan_dh_C PF02738:Ald_Xan_dh_C2 PF03450:CO_deh_flav_C PF00941:FAD_binding_5 PF00111:Fer2 PF01799:Fer2_2",HGNC:12805,Peroxisome,,"","",None,None,Non Essential,1V97,XDH,XDH,DQ089481,"","" 298,"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",2009-05-06 21:19:02 UTC,2009-06-30 03:51:49 UTC,P31040,Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q),"",">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDHEFDAVVVGAG GAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIH YMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLR YDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMI TRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLE IREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQ VLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGE ESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNT DLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYV DVGTGKVTLEYRPVIDKTLNEADCATVPPAIRSY",SDHA,Flavoprotein subunit of complex II; Fp,664,72692,7.41,">>> Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: FAD binding Function: oxidoreductase activity, acting on the CH-CH group of donors Function: catalytic activity Function: oxidoreductase activity || >>> Process: energy derivation by oxidation of organic compounds Process: main pathways of carbohydrate metabolism Process: tricarboxylic acid cycle Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available",Energy production and conversion,"PF00890:FAD_binding_2 PF02910:Succ_DH_flav_C",HGNC:10680,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",SDHA,SDHA,S79641,"","" 299,"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial",2009-05-06 21:19:24 UTC,2009-06-30 03:51:48 UTC,P21912,Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q),"",">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGP MVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLV PDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPA VLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV",SDHB,Iron-sulfur subunit of complex II; Ip,280,31630,8.92,">>> Function: catalytic activity Function: oxidoreductase activity Function: binding Function: ion binding Function: cation binding Function: transition metal ion binding Function: iron ion binding Function: transporter activity Function: electron transporter activity || >>> Process: energy derivation by oxidation of organic compounds Process: main pathways of carbohydrate metabolism Process: tricarboxylic acid cycle Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: cell Component: membrane",Energy production and conversion,PF00111:Fer2,HGNC:10681,Mitochondrion inner membrane,,"","",None,None,Non Essential,"",SDHB,SDHB,M32246,"","" 300,"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial",2009-05-06 21:19:48 UTC,2009-06-30 03:51:39 UTC,Q99643,Mono-heme cytochrome b. May act as a mediator of low potential couples in an electron flow through cardiac complex II. Is involved in system II of the mitochondrial electron transport chain which is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q),"",">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYSWSLPMAMSIC HRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFALVFPLMYHTWNGIRHLMWDLG KGLKIPQLYQSGVVVLVLTVLSSMGLAAM",SDHC,Succinate dehydrogenase complex subunit C; Integral membrane protein CII-3; QPs-1; QPs1; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL,169,18611,10.12,">>> Function: catalytic activity Function: oxidoreductase activity Function: oxidoreductase activity, acting on the CH-CH group of donors Function: succinate dehydrogenase activity || >>> Process: electron transport Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: energy derivation by oxidation of organic compounds Process: main pathways of carbohydrate metabolism Process: tricarboxylic acid cycle || >>> Component: cell Component: membrane",Energy production and conversion,PF01127:Sdh_cyt,HGNC:10682,Mitochondrion inner membrane,,"","",None,"71-93 105-127 147-168",Non Essential,"",SDHC,SDHC,BC066329,"","" 301,"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial",2009-05-06 21:20:10 UTC,2009-06-30 03:51:45 UTC,O14521,Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity),"",">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSKAASLHWTSER VVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDALQKAAKAGLLALSALTFAGLC YFNYHDVGICKAVAMLWKL",SDHD,CybS; Succinate-ubiquinone reductase membrane anchor subunit; QPs3; CII-4; Succinate dehydrogenase complex subunit D; Succinate-ubiquinone oxidoreductase cytochrome b small subunit,159,17043,8.75,">>> Function: binding Function: tetrapyrrole binding Function: heme binding || >>> Process: electron transport Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: energy derivation by oxidation of organic compounds Process: main pathways of carbohydrate metabolism Process: tricarboxylic acid cycle || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane Component: envelope Component: organelle envelope Component: mitochondrial envelope","",PF05328:CybS,HGNC:10683,Mitochondrion inner membrane,,"","",None,"64-85 91-111 121-142",Non Essential,"",SDHD,SDHD,BC071756,Chromosome:11,11q23 302,Adenylate cyclase type 1,2009-05-07 15:07:47 UTC,2009-06-30 03:51:42 UTC,Q08828,This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning,"",">Adenylate cyclase type 1 MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAATLKALAVLSL LAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPF ALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRL WRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMK EDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKIL GDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS NDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRKIFPGLIL SDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTT PGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLI FPQSVVVLLLLVFCICFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWS SKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELS GYTRTGGGAVSGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNL LPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEK DFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGIN VGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEML TYFLEGRTDGNGSQIRSLGLDRKMCPFGRAGLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA",ADCY1,Adenylate cyclase type I; ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase,1119,123442,8.49,">>> Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available",Signal transduction mechanisms,PF00211:Guanylate_cyc,HGNC:232,Membrane,,"","",None,"64-84 88-108 125-145 158-178 183-203 214-234 611-631 635-655 674-694 725-745 753-773 775-794",Non Essential,"",ADCY1,ADCY1,L05500,"","" 303,Adenylate cyclase type 2,2009-05-07 15:08:05 UTC,2009-06-30 03:51:43 UTC,Q08462,"This is a membrane-bound, calmodulin-insensitive adenylyl cyclase","",">Adenylate cyclase type 2 MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGL EVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFF LFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKH LMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHN LYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPIS LPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRA SVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQA IDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFF LSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVAL VGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKK EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGL ECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFAL VGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVL QTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNVAS",ADCY2,Adenylate cyclase type II; ATP pyrophosphate-lyase 2; Adenylyl cyclase 2,1091,123605,8.15,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:233,Membrane,,"","",None,"46-66 76-96 108-128 133-153 159-179 187-207 602-622 628-652 680-701 734-755 763-780 801-821",Non Essential,1AB8,ADCY2,ADCY2,L21993,"","" 304,Adenylate cyclase type 3,2009-05-07 15:08:30 UTC,2009-06-30 03:51:37 UTC,O60266,Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration,"",">Adenylate cyclase type 3 MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYF KRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLP YVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVA QQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLML SILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFAR FDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETY LIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSF PNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEK QSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDR TRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQ VSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKY SMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKR DEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGST YMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVL AGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLK GRDKLATFPNGPSVTLPHQVVDNS",ADCY3,"Adenylate cyclase type III; AC-III; ATP pyrophosphate-lyase 3; Adenylyl cyclase 3; AC3; Adenylate cyclase, olfactive type",1144,128962,6.55,">>> Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available",Signal transduction mechanisms,PF00211:Guanylate_cyc,HGNC:234,Membrane,,"","",None,"80-100 105-125 139-159 173-193 226-246 381-401 633-653 664-684 708-728 754-774 775-795 833-853",Non Essential,"",ADCY3,ADCY3,AB011083,"","" 305,Adenylate cyclase type 4,2009-05-07 15:08:47 UTC,2009-06-30 03:51:45 UTC,Q8NFM4,"This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)","",">Adenylate cyclase type 4 MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALG GFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGMRD AAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSL HSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIV GFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCR AIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG AYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKP FAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDF NPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILFVC FSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSS MISNLSWELPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLI VRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRL LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFD ELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNN FRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIK VKGKGQLCTYFLNTDLTRTGPPSATLG",ADCY4,Adenylate cyclase type IV; ATP pyrophosphate-lyase 4; Adenylyl cyclase 4,1077,119796,7.50,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:235,Membrane,,"","",None,"29-50 61-80 94-117 120-138 141-162 170-190 586-607 611-633 664-687 715-736 744-764 791-807",Non Essential,"",ADCY4,ADCY4,BC117475,Chromosome:14,14q12 306,Adenylate cyclase type 5,2009-05-07 15:09:01 UTC,2009-06-30 03:51:42 UTC,O95622,"This is a membrane-bound, calcium-inhibitable adenylyl cyclase","",">Adenylate cyclase type 5 MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLA SRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSA AAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCL ALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGV ILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAA VLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL VMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVN MRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNA YLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFED PKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASL VFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYF TYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEH ATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAA HFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLE KIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIG ARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL S",ADCY5,Adenylate cyclase type V; ATP pyrophosphate-lyase 5; Adenylyl cyclase 5,1261,138909,7.25,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:236,Membrane,,"","",None,"196-216 242-262 268-288 299-319 325-345 349-369 374-394 770-790 792-812 836-856 910-930 935-955 984-1004",Non Essential,1U0H,ADCY5,ADCY5,BK000371,"","" 307,Adenylate cyclase type 6,2009-05-07 15:09:18 UTC,2009-06-30 03:51:48 UTC,O43306,"Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)","",">Adenylate cyclase type 6 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAF IRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLY QRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWV VSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNR GDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHV AMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW QFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRK EEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR AIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGI YASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIR SCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALY LHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAV MFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQ VGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDST GVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS",ADCY6,Adenylate cyclase type VI; ATP pyrophosphate-lyase 6; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase,1168,130617,8.27,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:237,Membrane,,"","",None,"152-168 181-197 214-230 239-255 259-275 289-305 674-691 702-718 743-759 820-836 839-855 897-913",Non Essential,1U0H,ADCY6,ADCY6,BC064923,Chromosome:12,12q12-q13 308,Adenylate cyclase type 7,2009-05-07 15:09:35 UTC,2009-06-30 03:51:44 UTC,P51828,"This is a membrane-bound, calcium-inhibitable adenylyl cyclase","",">Adenylate cyclase type 7 MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAF LVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLL PFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFT YTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSI LYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKM GLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLES WGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTR PCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGLVAC VLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVG NETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCC GQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNE IIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINR HSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCEC RGLINVKGKGELRTYFVCTDTAKFQGLGLN",ADCY7,Adenylate cyclase type VII; ATP pyrophosphate-lyase 7; Adenylyl cyclase 7,1080,120310,8.16,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:238,Membrane,,"","",None,"34-54 63-83 95-117 122-142 147-167 176-196 595-615 620-640 669-688 718-737 746-773 794-814",Non Essential,"",ADCY7,ADCY7,BC126271,Chromosome:16,16q12-q13 309,Adenylate cyclase type 8,2009-05-07 15:09:52 UTC,2009-06-30 03:51:37 UTC,P40145,"This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity)","",">Adenylate cyclase type 8 MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASD PAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSD FFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDP LKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFA TYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAF LETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMI KTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLN GDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFD NIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSL EHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLI LRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG VLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLL AVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDA VGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEK QQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASR MDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQY SLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP",ADCY8,Adenylate cyclase type VIII; ATP pyrophosphate-lyase 8; Adenylyl cyclase 8; Ca(2+)/calmodulin-activated adenylyl cyclase,1251,140124,6.99,">>> Function: cyclase activity Function: adenylate cyclase activity Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: cell Component: membrane Component: intrinsic to membrane Component: integral to membrane",Signal transduction mechanisms,"PF06327:DUF1053 PF00211:Guanylate_cyc",HGNC:239,Membrane,,"","",None,"183-203 212-232 247-267 274-294 296-316 321-341 716-736 738-758 787-807 831-851 861-881 894-914",Non Essential,"",ADCY8,ADCY8,M83533,"","" 310,Adenylate cyclase type 9,2009-05-07 15:10:07 UTC,2009-06-30 03:51:36 UTC,O60503,May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity),"",">Adenylate cyclase type 9 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGG GRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRS RLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTAT ARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWE LLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQG DEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGV HTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVA DQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKG RWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEE VIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIR MVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYC NFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQ EVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTY SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGL NTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDT VNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISP DIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFGKAIEK DDCDETGIEEANELTKLNVSKSV",ADCY9,Adenylate cyclase type IX; ATP pyrophosphate-lyase 9; Adenylyl cyclase 9,1353,150702,7.35,">>> Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available",Signal transduction mechanisms,PF00211:Guanylate_cyc,HGNC:240,Membrane,,"","",None,"118-138 142-162 172-192 216-235 242-259 281-301 787-807 819-839 868-888 892-912 921-941 976-996",Non Essential,"",ADCY9,ADCY9,AY028959,Chromosome:16,16p13.3 311,Adenylate cyclase type 10,2009-05-07 15:10:20 UTC,2009-06-30 03:51:46 UTC,Q96PN6,"Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation","",">Adenylate cyclase type 10 MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQ LVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFETQEWEEGLD IRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQ RAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNK QLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGF PGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMY YPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMACLICNRKEDYPLLGRN KEINYFMYTMKKFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRIIAISLNKISFHQTFYTIQMF MANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIFHVQFPISREISRMSTLKKQKQLEILFMKIL KLIVKEERIIFIIDEAQFVDSTSWRFMEKLIRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVVGAV QPNDISNKICLDLNVSCISKELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFK YSIKLTEKLNMVTLHSDKESEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTF TTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLKPSEGMDHGEE EQLRELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEEDAHRCDHCRGRDFIPYHHFTV NIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAFFPENRSPEEIREKILNFFDHVLTKMKTSDE DIIPLESCQCEEILEIVILPLAHHFLALGENDKALYYFLEIASAYLIFCDNYMAYMYLNEGQKLLKTLKK DKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQ AQESPPPGKKRLAQLYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSL YHHLAGYKGVWFKYEVMAMEHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQ NPNRHYQSLCRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEECL EFIHQYENNRILKFHSGLLLGLYSSVAIWYARLQEWDNFYKFSNRAKNLLPRRTMTLTYYDGISRYMEGQ VLHLQKQIKEQSENAQASGEELLKNLENLVAQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRL SETQGNILEKCWLNMNKESWYSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFLMRANTVDNHF",ADCY10,Adenylate cyclase homolog; Testicular soluble adenylyl cyclase; Germ cell soluble adenylyl cyclase; hsAC; sAC; AH-related protein,1610,187138,7.32,">>> Function: catalytic activity Function: lyase activity Function: phosphorus-oxygen lyase activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism Process: nucleotide metabolism Process: nucleotide biosynthesis Process: cyclic nucleotide biosynthesis Process: cellular process Process: cell communication Process: signal transduction Process: intracellular signaling cascade || >>> Component: Not Available",Signal transduction mechanisms,PF00211:Guanylate_cyc,HGNC:21285,Cell membrane,,"","",None,None,Non Essential,"",ADCY10,ADCY10,BC117372,"","" 312,Acetylcholinesterase,2009-05-07 15:14:35 UTC,2009-06-30 03:51:50 UTC,P22303,Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis,"",">Acetylcholinesterase MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAE PPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLA LQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRAT QLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAG DFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPL DPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQAC AFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL",ACHE,AChE,614,67797,6.24,">>> Function: catalytic activity Function: hydrolase activity Function: hydrolase activity, acting on ester bonds Function: carboxylic ester hydrolase activity Function: cholinesterase activity || >>> Process: Not Available || >>> Component: Not Available",Lipid transport and metabolism,"PF08674:AChE_tetra PF00135:COesterase",HGNC:108,Isoform H:Cell membrane,,"","",1-31,None,Non Essential,1F8U,ACHE,ACHE,AF312032,"","" 313,NF-kappa-B essential modulator,2009-05-07 20:37:40 UTC,2009-06-30 03:51:39 UTC,Q9Y6K9,Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa- B-mediated protection from cytokine toxicity (By similarity),"",">NF-kappa-B essential modulator MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQ ILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKA SVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVE AALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEV IDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQES ARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE",IKBKG,NEMO; NF-kappa-B essential modifier; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IkB kinase subunit gamma; I-kappa-B kinase gamma; IKK-gamma; IKKG; IkB kinase-associated protein 1; IKKAP1; FIP-3,419,48198,5.46,"","Replication, recombination and repair","",HGNC:5961,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",IKBKG,IKBKG,BC050612,"","" 314,Inhibitor of nuclear factor kappa-B kinase subunit alpha,2009-05-07 20:38:07 UTC,2009-06-30 03:51:43 UTC,O15111,"Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF- kappa-B-regulated promoters during inflammatory responses triggered by cytokines","",">Inhibitor of nuclear factor kappa-B kinase subunit alpha MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNH ANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKI IHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTM VFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENWLQLML NWDPQQRGGPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTG SQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLD LERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESL EQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALS NIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTP QDGETSAQMIEENLNCLGHLSTIIHEANEEQGNSMMNLDWSWLTE",CHUK,I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA,745,84655,6.72,">>> Function: protein serine/threonine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:1974,Cytoplasm. Nucleus,,"","",None,None,Non Essential,"",CHUK,CHUK,U22512,Chromosome:10,10q24-q25 315,Inhibitor of nuclear factor kappa-B kinase subunit beta,2009-05-07 20:38:23 UTC,2009-06-30 03:51:44 UTC,O14920,Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3,"",">Inhibitor of nuclear factor kappa-B kinase subunit beta MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTH PNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENR IIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGT LAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLM LMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEED QELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSI QIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTL DDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVE EVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPE PAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS",IKBKB,I-kappa-B-kinase beta; IkBKB; IKK-beta; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB,756,86565,5.53,">>> Function: protein serine/threonine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","","PF00069:Pkinase PF00240:ubiquitin",HGNC:5960,Cytoplasm,,"","",None,None,Non Essential,"",IKBKB,IKBKB,BC006231,"","" 316,Inhibitor of nuclear factor kappa-B kinase subunit epsilon,2009-05-07 20:38:56 UTC,2009-06-30 03:51:35 UTC,Q14164,Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response,"",">Inhibitor of nuclear factor kappa-B kinase subunit epsilon MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKL FAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGN IMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVT LYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPI LANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQ EYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELK AAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKS RMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAA CNTEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDN NRIIERLNRVPAPPDV",IKBKE,I kappa-B kinase epsilon; IkBKE; IKK-epsilon; IKK-E; Inducible I kappa-B kinase; IKK-i,716,80463,7.90,">>> Function: protein serine/threonine kinase activity Function: binding Function: nucleotide binding Function: purine nucleotide binding Function: adenyl nucleotide binding Function: ATP binding Function: catalytic activity Function: transferase activity Function: transferase activity, transferring phosphorus-containing groups Function: kinase activity Function: protein kinase activity || >>> Process: physiological process Process: metabolism Process: macromolecule metabolism Process: biopolymer metabolism Process: biopolymer modification Process: protein modification Process: protein amino acid phosphorylation || >>> Component: Not Available","",PF00069:Pkinase,HGNC:14552,Cytoplasm (Probable),,"","",None,None,Non Essential,"",IKBKE,IKBKE,BC105924,"","" 317,"Thioredoxin, mitochondrial",2009-05-07 21:45:08 UTC,2009-06-30 03:51:37 UTC,Q99757,Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity,"",">Thioredoxin, mitochondrial MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDF QDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMK NGDVVDKFVGIKDEDQLEAFLKKLIG",TXN2,Mt-Trx; MTRX; Thioredoxin-2,166,18384,8.49,">>> Function: transporter activity Function: electron transporter activity || >>> Process: physiological process Process: metabolism Process: cellular metabolism Process: generation of precursor metabolites and energy Process: electron transport || >>> Component: Not Available","Posttranslational modification, protein turnover, chaperones",PF00085:Thioredoxin,HGNC:17772,Mitochondrion,,"","",None,None,Non Essential,"",TXN2,TXN2,BC050610,Chromosome:22,22q13.1 318,Apolipoprotein A-I,2009-05-07 22:00:09 UTC,2009-06-30 03:51:45 UTC,P02647,Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT),"",">Apolipoprotein A-I MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKL LDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYR QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGG ARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ",APOA1,Apo-AI; ApoA-I; Contains: RecName: Apolipoprotein A-I(1-242),267,30778,5.50,">>> Function: binding Function: lipid binding || >>> Process: metabolism Process: macromolecule metabolism Process: protein metabolism Process: cellular protein metabolism Process: lipoprotein metabolism Process: physiological process Process: cellular physiological process Process: transport Process: lipid transport || >>> Component: extracellular region","",PF01442:Apolipoprotein,HGNC:600,Secreted,,"","",1-18,None,Non Essential,1AV1,APOA1,APOA1,BC110286,Chromosome:11,11q23-q24 319,Fatty aldehyde dehydrogenase,2009-05-07 22:06:07 UTC,2009-06-30 03:51:48 UTC,P51648,Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length,"",">Fatty aldehyde dehydrogenase MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDF MLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELS ENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGG KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYE RIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAIN FINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY",ALDH3A2,Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10; Microsomal aldehyde dehydrogenase,485,54849,7.99,"",Energy production and conversion,PF00171:Aldedh,HGNC:403,Endoplasmic reticulum membrane,,"","",None,464-480,Non Essential,"",ALDH3A2,ALDH3A2,BC002430,Chromosome:17,17p11.2 320,"Aldehyde dehydrogenase, mitochondrial",2009-05-07 22:06:23 UTC,2009-06-30 03:51:50 UTC,P05091,An aldehyde + NAD(+) + H(2)O = an acid + NADH,"",">Aldehyde dehydrogenase, mitochondrial MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAE GDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLD MVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKV AEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLK RVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGN PFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGS GRELGEYGLQAYTEVKTVTVKVPQKNS",ALDH2,ALDH class 2; ALDHI; ALDH-E2,517,56382,7.05,"",Energy production and conversion,PF00171:Aldedh,HGNC:404,Mitochondrion matrix,,"","",None,None,Non Essential,1OF7,ALDH2,ALDH2,M54931,Chromosome:12,12q24.2 321,"Aldehyde dehydrogenase, dimeric NADP-preferring",2009-05-07 22:06:44 UTC,2009-06-30 03:51:34 UTC,P30838,"ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes","",">Aldehyde dehydrogenase, dimeric NADP-preferring MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEE IEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPS ELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLE LGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSR DYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH",ALDH3A1,Aldehyde dehydrogenase family 3 member A1; Aldehyde dehydrogenase 3; ALDHIII,453,50380,6.52,"",Energy production and conversion,PF00171:Aldedh,HGNC:405,Cytoplasm,,"","",None,None,Non Essential,"",ALDH3A1,ALDH3A1,BC021194,Chromosome:17,17p11.2 322,Retinal dehydrogenase 1,2009-05-07 22:07:01 UTC,2009-06-30 03:51:41 UTC,P00352,Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity),"",">Retinal dehydrogenase 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQA FQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI QGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIK EAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLA DADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQ YDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVK TVTVKISQKNS",ALDH1A1,"RALDH 1; RalDH1; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; ALHDII; ALDH-E1",501,54862,6.71,"",Energy production and conversion,PF00171:Aldedh,HGNC:402,Cytoplasm,,"","",None,None,Non Essential,1BXS,ALDH1A1,ALDH1A1,K03000,"","" 323,Aldehyde dehydrogenase family 3 member B2,2009-05-07 22:07:19 UTC,2009-06-30 03:51:37 UTC,P48448,An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H,"",">Aldehyde dehydrogenase family 3 member B2 MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGNCVVLKPSEISQGTEKVLA EVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGGKNPCYVDD NCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQF QRLRALLGCGRVAIGGQSNESDRYIAPTVLVDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKP LALYAFSNSSQVVNQMLERTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLA PSGLEKLKEIRYPPYTDWNQQLLRWGMGSQSCTLL",ALDH3B2,Aldehyde dehydrogenase 8,385,42670,5.97,"",Energy production and conversion,PF00171:Aldedh,HGNC:411,"",,"","",None,None,Non Essential,"",ALDH3B2,ALDH3B2,BC007685,Chromosome:11,11q13 324,"Aldehyde dehydrogenase X, mitochondrial",2009-05-07 22:07:36 UTC,2009-06-30 03:51:36 UTC,P30837,"ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation","",">Aldehyde dehydrogenase X, mitochondrial MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAE GDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLASLETLDNGKPFQESYALDLD EVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKV AEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLK RVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGN PFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGN GRELGEDGLKAYTEVKTVTIKVPQKNS",ALDH1B1,Aldehyde dehydrogenase family 1 member B1; Aldehyde dehydrogenase 5,517,57239,6.79,"",Energy production and conversion,PF00171:Aldedh,HGNC:407,Mitochondrion matrix,,"","",None,None,Non Essential,"",ALDH1B1,ALDH1B1,BC001619,"","" 325,4-trimethylaminobutyraldehyde dehydrogenase,2009-05-07 22:07:50 UTC,2009-06-30 03:51:49 UTC,P49189,Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction,"",">4-trimethylaminobutyraldehyde dehydrogenase MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSG MERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFG YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQ GGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMAN FLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQG AKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDV ESAF",ALDH9A1,TMABADH; Aldehyde dehydrogenase family 9 member A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R-aminobutyraldehyde dehydrogenase,494,53802,5.61,"",Energy production and conversion,PF00171:Alded