id,toxin_id,toxin,target,uniprot,mechanism
1,T3D0001,Arsenic,"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial",P29803,"Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001)"
2,T3D0001,Arsenic,Hemoglobin subunit beta,P68871,Arsenic binds to hemoglobin. (R052)
3,T3D0001,Arsenic,Hemoglobin subunit alpha,P69905,Arsenic binds to hemoglobin. (R052)
4,T3D0001,Arsenic,Haptoglobin,P00738,Arsenic binds to haptoglobin. (R052)
5,T3D0001,Arsenic,Estrogen receptor,P03372,Arsenic binds to the estrogen receptor. (R054)
6,T3D0001,Arsenic,Glucocorticoid receptor,P04150,Arsenic binds to the glucocorticoid receptor. (R054)
7,T3D0001,Arsenic,"Glutathione reductase, mitochondrial",P00390,"Arsenic binds glutathione reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
8,T3D0001,Arsenic,Kelch-like ECH-associated protein 1,Q14145,Arsenic binds to kelch-like ECH-associated protein 1. (R054)
9,T3D0001,Arsenic,Poly [ADP-ribose] polymerase 1,P09874,Arsenic binding of PARP-1 is believed to induce carcinogenesis by affecting DNA repair. (R054)
11,T3D0001,Arsenic,Tubulin beta chain,P07437,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
14,T3D0001,Arsenic,"Thioredoxin reductase 1, cytoplasmic",Q16881,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
16,T3D0002,Lead,"Ferrochelatase, mitochondrial",P22830,"Lead inhibition of ferrochelatase prevents the biosynthesis of heme, which is a necesssary cofactor of hemoglobin. (R056)"
17,T3D0002,Lead,Delta-aminolevulinic acid dehydratase,P13716,"Lead inhibition of ALAD prevents the biosynthesis of heme, which is a necesssary cofactor of hemoglobin. (R056)"
18,T3D0002,Lead,Glutamate [NMDA] receptor subunit zeta-1,Q05586,"Lead exhibits competitive inhibition at the NMDA receptor, affecting neurotransmitter release. (R063)"
19,T3D0002,Lead,Glutamate [NMDA] receptor subunit epsilon-2,Q13224,"Lead exhibits competitive inhibition at the NMDA receptor, affecting neurotransmitter release. (R063)"
20,T3D0002,Lead,Glutamate [NMDA] receptor subunit epsilon-1,Q12879,"Lead exhibits competitive inhibition at the NMDA receptor, affecting neurotransmitter release. (R063)"
21,T3D0002,Lead,Glutamate [NMDA] receptor subunit 3B,O60391,"Lead exhibits competitive inhibition at the NMDA receptor, affecting neurotransmitter release. (R063)"
22,T3D0002,Lead,Glutamate [NMDA] receptor subunit epsilon-3,Q14957,"Lead exhibits competitive inhibition at the NMDA receptor, affecting neurotransmitter release. (R063)"
23,T3D0002,Lead,Glutamate [NMDA] receptor subunit epsilon-4,O15399,"Lead exhibits competitive inhibition at the NMDA receptor, affecting neurotransmitter release. (R063)"
24,T3D0002,Lead,Calmodulin,P62158,"Lead has been shown to competitively inhibit calcium's binding of calmodulin, interfering with neurotransmitter release. Lead binding of calmodulin causes inproper activation, altering proper functioning of cAMP messenger pathways. (R061)"
25,T3D0002,Lead,Thymosin beta-4,P62328,"Lead has been shown to bind thymosin beta-4, which funtions in the modulation of cytoskeletion, stimulation of CaM-dependent kinases, and GABA-A receptor complex function. It is also an immunotransmitter. (R062)"
26,T3D0002,Lead,Acyl-CoA-binding protein,P07108,"Lead is known to bind ACBP, which is responsible for the regulation of various processes such as acyl-CoA metabolism, GABA-A/benzodiazepine receptor modulation, steroidogenesis, intestinal cholecystokinin release, and insulin secretion. (R062)"
27,T3D0002,Lead,Protein kinase C alpha type,P17252,"Lead exhibits competitive inhibition with calcium at protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R266)"
28,T3D0002,Lead,Protein kinase C beta type,P05771,"Lead exhibits competitive inhibition with calcium at protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R266)"
29,T3D0002,Lead,Protein kinase C gamma type,P05129,"Lead exhibits competitive inhibition with calcium at protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R266)"
30,T3D0002,Lead,Protein kinase C delta type,Q05655,"Lead exhibits competitive inhibition with calcium at protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R266)"
31,T3D0002,Lead,Protein kinase C iota type,P41743,"Lead exhibits competitive inhibition with calcium at protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R266)"
32,T3D0002,Lead,Protein kinase C epsilon type,Q02156,"Lead exhibits competitive inhibition with calcium at protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R266)"
33,T3D0002,Lead,Protein kinase C eta type,P24723,"Lead exhibits competitive inhibition with calcium at protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R266)"
34,T3D0002,Lead,Protein kinase C theta type,Q04759,"Lead exhibits competitive inhibition with calcium at protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R266)"
35,T3D0002,Lead,Protein kinase C zeta type,Q05513,"Lead exhibits competitive inhibition with calcium at protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R266)"
36,T3D0002,Lead,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,Lead binds to sodium/potassium-transporting ATPases. (R065)
37,T3D0002,Lead,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,Lead binds to sodium/potassium-transporting ATPases. (R065)
38,T3D0002,Lead,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,Lead binds to sodium/potassium-transporting ATPases. (R065)
39,T3D0002,Lead,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,Lead binds to sodium/potassium-transporting ATPases. (R065)
40,T3D0002,Lead,Sodium/potassium-transporting ATPase subunit beta-1,P05026,Lead binds to sodium/potassium-transporting ATPases. (R065)
41,T3D0002,Lead,Sodium/potassium-transporting ATPase subunit beta-2,P14415,Lead binds to sodium/potassium-transporting ATPases. (R065)
42,T3D0002,Lead,Sodium/potassium-transporting ATPase subunit beta-3,P54709,Lead binds to sodium/potassium-transporting ATPases. (R065)
43,T3D0002,Lead,Sodium/potassium-transporting ATPase gamma chain,P54710,Lead binds to sodium/potassium-transporting ATPases. (R065)
86,T3D0005,Polychlorinated biphenyls,Aryl hydrocarbon receptor,P35869,"Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. (R015)"
87,T3D0005,Polychlorinated biphenyls,Estrogen sulfotransferase,P49888,"PCBs can cause endocrine disurption by binding to estrogen sulfotransferase, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. (R013, R203)"
88,T3D0005,Polychlorinated biphenyls,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
97,T3D0005,Polychlorinated biphenyls,Uteroglobin,P11684,PCBs will bioaccumulate by binding to receptor proteins such as uteroglobin. (R071)
98,T3D0006,Benzene,Hemoglobin subunit alpha,P69905,The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)
99,T3D0006,Benzene,Hemoglobin subunit beta,P68871,The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)
100,T3D0006,Benzene,Hemoglobin subunit gamma-1,P69891,The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)
101,T3D0006,Benzene,Hemoglobin subunit gamma-2,P69892,The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)
102,T3D0006,Benzene,Hemoglobin subunit delta,P02042,The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)
103,T3D0006,Benzene,Hemoglobin subunit epsilon,P02100,The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)
104,T3D0006,Benzene,Hemoglobin subunit theta-1,P09105,The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)
105,T3D0006,Benzene,Hemoglobin subunit zeta,P02008,The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)
106,T3D0006,Benzene,Serum albumin,P02768,The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)
107,T3D0006,Benzene,Histone H4,P62805,Direct binding of histone leads to protein damage. (R016)
108,T3D0006,Benzene,Histone H3.1,P68431,Direct binding of histone leads to protein damage. (R016)
109,T3D0006,Benzene,Histone H3.1t,Q16695,Direct binding of histone leads to protein damage. (R016)
110,T3D0006,Benzene,Histone H3.3,P84243,Direct binding of histone leads to protein damage. (R016)
111,T3D0006,Benzene,DNA polymerase subunit gamma-1,P54098,Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)
112,T3D0006,Benzene,Ribonucleoside-diphosphate reductase large subunit,P23921,Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)
113,T3D0006,Benzene,Ribonucleoside-diphosphate reductase subunit M2,P31350,Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)
114,T3D0006,Benzene,Tubulin alpha-1B chain,P68363,Direct binding of tubulin leads to protein damage. (R016)
115,T3D0006,Benzene,Tubulin alpha-3C/D chain,Q13748,Direct binding of tubulin leads to protein damage. (R016)
116,T3D0006,Benzene,Tubulin alpha-4A chain,P68366,Direct binding of tubulin leads to protein damage. (R016)
117,T3D0006,Benzene,Tubulin beta chain,P07437,Direct binding of tubulin leads to protein damage. (R016)
118,T3D0006,Benzene,Tubulin beta-2A chain,Q13885,Direct binding of tubulin leads to protein damage. (R016)
119,T3D0006,Benzene,Tubulin beta-2C chain,P68371,Direct binding of tubulin leads to protein damage. (R016)
120,T3D0006,Benzene,Tubulin beta-3 chain,Q13509,Direct binding of tubulin leads to protein damage. (R016)
121,T3D0006,Benzene,Tubulin beta-4 chain,P04350,Direct binding of tubulin leads to protein damage. (R016)
122,T3D0006,Benzene,Tubulin gamma-1 chain,P23258,Direct binding of tubulin leads to protein damage. (R016)
123,T3D0006,Benzene,DNA topoisomerase 2-alpha,P11388,Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)
124,T3D0006,Benzene,DNA topoisomerase 2-beta,Q02880,Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)
125,T3D0007,Cadmium,Estrogen receptor,P03372,"Cadmium binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. (R059)"
126,T3D0007,Cadmium,Estrogen receptor beta,Q92731,"Cadmium binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. (R059)"
127,T3D0007,Cadmium,Mitogen-activated protein kinase 1,P28482,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
128,T3D0007,Cadmium,Mitogen-activated protein kinase 3,P27361,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
129,T3D0007,Cadmium,Mitogen-activated protein kinase 4,P31152,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
130,T3D0007,Cadmium,Mitogen-activated protein kinase 6,Q16659,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
131,T3D0007,Cadmium,Mitogen-activated protein kinase 7,Q13164,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
132,T3D0007,Cadmium,Mitogen-activated protein kinase 8,P45983,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
133,T3D0007,Cadmium,Mitogen-activated protein kinase 9,P45984,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
134,T3D0007,Cadmium,Mitogen-activated protein kinase 10,P53779,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
135,T3D0007,Cadmium,Mitogen-activated protein kinase 11,Q15759,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
136,T3D0007,Cadmium,Mitogen-activated protein kinase 12,P53778,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
137,T3D0007,Cadmium,Mitogen-activated protein kinase 13,O15264,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
138,T3D0007,Cadmium,Mitogen-activated protein kinase 14,Q16539,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
139,T3D0007,Cadmium,C-jun-amino-terminal kinase-interacting protein 2,Q13387,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
140,T3D0007,Cadmium,C-jun-amino-terminal kinase-interacting protein 4,O60271,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
145,T3D0009,Benzo[a]pyrene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
146,T3D0009,Benzo[a]pyrene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
148,T3D0010,Benzo[b]fluoranthene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
149,T3D0010,Benzo[b]fluoranthene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
150,T3D0011,Chloroform,Potassium voltage-gated channel subfamily H member 2,Q12809,"Chloroform has been shown to block HERG potassium channels, causing cardiac arrest. (R070)"
151,T3D0012,"DDT, P,P'-",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
152,T3D0012,"DDT, P,P'-",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
153,T3D0012,"DDT, P,P'-",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
154,T3D0012,"DDT, P,P'-",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
155,T3D0012,"DDT, P,P'-",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
156,T3D0012,"DDT, P,P'-",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
157,T3D0012,"DDT, P,P'-",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
158,T3D0012,"DDT, P,P'-",Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
159,T3D0012,"DDT, P,P'-",Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
160,T3D0012,"DDT, P,P'-",Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
161,T3D0012,"DDT, P,P'-",Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
162,T3D0012,"DDT, P,P'-",Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
163,T3D0012,"DDT, P,P'-",Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
164,T3D0012,"DDT, P,P'-",Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
165,T3D0012,"DDT, P,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
166,T3D0012,"DDT, P,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
167,T3D0012,"DDT, P,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
168,T3D0012,"DDT, P,P'-",Calmodulin,P62158,"DDT inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
169,T3D0012,"DDT, P,P'-",Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
170,T3D0012,"DDT, P,P'-",Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
171,T3D0012,"DDT, P,P'-",Androgen receptor,P10275,DDT is also believed to adversely affect the reproductive system by mimicking endogenous hormones and binding to the estrogen and adrogen receptors. (R153)
172,T3D0013,Aroclor 1254,ATP-citrate synthase,P53396,"Aroclor 1254 inhibits ATP-citrate synthase, causing a decrease in fatty acid synthesis. (R204)"
174,T3D0013,Aroclor 1254,Aryl hydrocarbon receptor,P35869,"Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. (R015)"
175,T3D0013,Aroclor 1254,Estrogen sulfotransferase,P49888,"PCBs can cause endocrine disurption by binding to estrogen sulfotransferase, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. (R013, R203)"
176,T3D0013,Aroclor 1254,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
185,T3D0013,Aroclor 1254,Uteroglobin,P11684,PCBs will bioaccumulate by binding to receptor proteins such as uteroglobin. (R071)
189,T3D0014,Aroclor 1260,Aryl hydrocarbon receptor,P35869,"Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. (R015)"
190,T3D0014,Aroclor 1260,Estrogen sulfotransferase,P49888,"PCBs can cause endocrine disurption by binding to estrogen sulfotransferase, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. (R013, R203)"
191,T3D0014,Aroclor 1260,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
200,T3D0014,Aroclor 1260,Uteroglobin,P11684,PCBs will bioaccumulate by binding to receptor proteins such as uteroglobin. (R071)
202,T3D0015,"Dibenzo[a,h]anthracene",Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
203,T3D0015,"Dibenzo[a,h]anthracene",Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
204,T3D0016,Trichloroethylene,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial",Q15118,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase. (R160)"
205,T3D0016,Trichloroethylene,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial",Q15119,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase. (R160)"
206,T3D0016,Trichloroethylene,Alcohol dehydrogenase 1A,P07327,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (R161)"
207,T3D0016,Trichloroethylene,Alcohol dehydrogenase 1B,P00325,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (R161) "
208,T3D0016,Trichloroethylene,Alcohol dehydrogenase 1C,P00326,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (R161) "
209,T3D0016,Trichloroethylene,Alcohol dehydrogenase class 4 mu/sigma chain,P40394,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (R161) "
210,T3D0016,Trichloroethylene,Alcohol dehydrogenase class-3,P11766,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (R161) "
211,T3D0016,Trichloroethylene,Alcohol dehydrogenase 4,P08319,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (R161) "
212,T3D0016,Trichloroethylene,Alcohol dehydrogenase 6,P28332,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (R161) "
214,T3D0017,Dieldrin,Alpha-synuclein,P37840,"Dieldrin binds to alpha-synuclein, leading to the formation of intracellular fibrils. (R155)"
215,T3D0017,Dieldrin,Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
216,T3D0017,Dieldrin,Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
217,T3D0017,Dieldrin,Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
218,T3D0017,Dieldrin,Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
219,T3D0017,Dieldrin,Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
220,T3D0017,Dieldrin,Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
221,T3D0017,Dieldrin,Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
222,T3D0017,Dieldrin,Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
223,T3D0017,Dieldrin,Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
224,T3D0017,Dieldrin,Gamma-aminobutyric acid receptor subunit delta,O14764,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
225,T3D0017,Dieldrin,Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
226,T3D0017,Dieldrin,Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
227,T3D0017,Dieldrin,Gamma-aminobutyric acid receptor subunit pi,O00591,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
228,T3D0017,Dieldrin,Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
229,T3D0017,Dieldrin,Gamma-aminobutyric acid receptor subunit rho-2,P28476,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
230,T3D0017,Dieldrin,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
231,T3D0017,Dieldrin,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
232,T3D0017,Dieldrin,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
233,T3D0017,Dieldrin,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
234,T3D0017,Dieldrin,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
235,T3D0017,Dieldrin,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
236,T3D0017,Dieldrin,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
237,T3D0017,Dieldrin,Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
238,T3D0017,Dieldrin,Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
239,T3D0017,Dieldrin,Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
240,T3D0017,Dieldrin,Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
241,T3D0017,Dieldrin,Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
242,T3D0017,Dieldrin,Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
243,T3D0017,Dieldrin,Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
244,T3D0017,Dieldrin,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
245,T3D0017,Dieldrin,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
246,T3D0017,Dieldrin,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
247,T3D0018,"Chromium, hexavalent",Mitogen-activated protein kinase 1,P28482,Chromium has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. (R075)
248,T3D0018,"Chromium, hexavalent",Mitogen-activated protein kinase 3,P27361,Chromium has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. (R075)
249,T3D0018,"Chromium, hexavalent",Histone deacetylase 1,Q13547,"Chromium can cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. (R076)"
250,T3D0018,"Chromium, hexavalent",Metal regulatory transcription factor 1,Q14872,"Chromium may increase its own toxicity by modifying metal regulatory transcription factor 1, causing the inhibition of zinc-induced metallothionein transcription. (R077)"
258,T3D0020,Chlordane,Steroid hormone receptor ERR1,P11474,Chlordane affects transcription by antagonizing estrogen-related receptors. (R162) 
259,T3D0020,Chlordane,Steroid hormone receptor ERR2,O95718,Chlordane affects transcription by antagonizing estrogen-related receptors. (R162) 
260,T3D0020,Chlordane,Estrogen-related receptor gamma,P62508,Chlordane affects transcription by antagonizing estrogen-related receptors. (R162)
261,T3D0020,Chlordane,Retinoic acid receptor beta,P10826,"Chlordane has been shown to bind and activate retinoic acid receptor, causing various developmental defects. (R163)"
262,T3D0020,Chlordane,Retinoic acid receptor gamma-1,P13631,"Chlordane has been shown to bind and activate retinoic acid receptor, causing various developmental defects. (R163)"
264,T3D0021,"DDE, P,P'-",Androgen receptor,P10275,DDE is also believed to adversely affect the reproductive system by mimicking endogenous hormones and binding to the estrogen and adrogen receptors. (R153) 
265,T3D0021,"DDE, P,P'-",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
266,T3D0021,"DDE, P,P'-",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
267,T3D0021,"DDE, P,P'-",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
268,T3D0021,"DDE, P,P'-",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
269,T3D0021,"DDE, P,P'-",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
270,T3D0021,"DDE, P,P'-",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
271,T3D0021,"DDE, P,P'-",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
272,T3D0021,"DDE, P,P'-",Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
273,T3D0021,"DDE, P,P'-",Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
274,T3D0021,"DDE, P,P'-",Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
275,T3D0021,"DDE, P,P'-",Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
276,T3D0021,"DDE, P,P'-",Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
277,T3D0021,"DDE, P,P'-",Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
278,T3D0021,"DDE, P,P'-",Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
279,T3D0021,"DDE, P,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
280,T3D0021,"DDE, P,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
281,T3D0021,"DDE, P,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
282,T3D0021,"DDE, P,P'-",Calmodulin,P62158,"DDE inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
283,T3D0021,"DDE, P,P'-",Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
284,T3D0021,"DDE, P,P'-",Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
289,T3D0024,Aldrin,Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
290,T3D0024,Aldrin,Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
291,T3D0024,Aldrin,Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
292,T3D0024,Aldrin,Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
293,T3D0024,Aldrin,Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
294,T3D0024,Aldrin,Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
295,T3D0024,Aldrin,Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
296,T3D0024,Aldrin,Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
297,T3D0024,Aldrin,Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
298,T3D0024,Aldrin,Gamma-aminobutyric acid receptor subunit delta,O14764,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
299,T3D0024,Aldrin,Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
300,T3D0024,Aldrin,Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
301,T3D0024,Aldrin,Gamma-aminobutyric acid receptor subunit pi,O00591,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
302,T3D0024,Aldrin,Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
303,T3D0024,Aldrin,Gamma-aminobutyric acid receptor subunit rho-2,P28476,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
304,T3D0024,Aldrin,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
305,T3D0024,Aldrin,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
306,T3D0024,Aldrin,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
307,T3D0024,Aldrin,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
308,T3D0024,Aldrin,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
309,T3D0024,Aldrin,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
310,T3D0024,Aldrin,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
311,T3D0024,Aldrin,Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
312,T3D0024,Aldrin,Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
313,T3D0024,Aldrin,Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
314,T3D0024,Aldrin,Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
315,T3D0024,Aldrin,Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
316,T3D0024,Aldrin,Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
317,T3D0024,Aldrin,Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
318,T3D0024,Aldrin,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
319,T3D0024,Aldrin,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
320,T3D0024,Aldrin,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
322,T3D0025,"DDD, P,P'-",Androgen receptor,P10275,DDD is also believed to adversely affect the reproductive system by mimicking endogenous hormones and binding to the estrogen and adrogen receptors. (R153) 
323,T3D0025,"DDD, P,P'-",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
324,T3D0025,"DDD, P,P'-",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
325,T3D0025,"DDD, P,P'-",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
326,T3D0025,"DDD, P,P'-",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
327,T3D0025,"DDD, P,P'-",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
328,T3D0025,"DDD, P,P'-",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
329,T3D0025,"DDD, P,P'-",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
330,T3D0025,"DDD, P,P'-",Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
331,T3D0025,"DDD, P,P'-",Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
332,T3D0025,"DDD, P,P'-",Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
333,T3D0025,"DDD, P,P'-",Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
334,T3D0025,"DDD, P,P'-",Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
335,T3D0025,"DDD, P,P'-",Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
336,T3D0025,"DDD, P,P'-",Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
337,T3D0025,"DDD, P,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
338,T3D0025,"DDD, P,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
339,T3D0025,"DDD, P,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
340,T3D0025,"DDD, P,P'-",Calmodulin,P62158,"DDD inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
341,T3D0025,"DDD, P,P'-",Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
342,T3D0025,"DDD, P,P'-",Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
346,T3D0027,Aroclor 1248,Aryl hydrocarbon receptor,P35869,"Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. (R015) "
347,T3D0027,Aroclor 1248,Estrogen sulfotransferase,P49888,"PCBs can cause endocrine disurption by binding to estrogen sulfotransferase, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. (R013, R203) "
348,T3D0027,Aroclor 1248,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
357,T3D0027,Aroclor 1248,Uteroglobin,P11684,PCBs will bioaccumulate by binding to receptor proteins such as uteroglobin. (R071) 
358,T3D0028,Cyanide,Cytochrome c oxidase subunit 1,P00395,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
359,T3D0028,Cyanide,Cytochrome c oxidase subunit 2,P00403,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
360,T3D0028,Cyanide,Cytochrome c oxidase subunit 3,P00414,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
361,T3D0028,Cyanide,"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial",P13073,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
362,T3D0028,Cyanide,"Cytochrome c oxidase subunit 5A, mitochondrial",P20674,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
363,T3D0028,Cyanide,"Cytochrome c oxidase subunit 5B, mitochondrial",P10606,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
364,T3D0028,Cyanide,"Cytochrome c oxidase subunit 6A1, mitochondrial",P12074,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
365,T3D0028,Cyanide,"Cytochrome c oxidase subunit 6A2, mitochondrial ",Q02221,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
366,T3D0028,Cyanide,Cytochrome c oxidase subunit 6B1,P14854,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
367,T3D0028,Cyanide,Cytochrome c oxidase subunit 6C,P09669,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
368,T3D0028,Cyanide,"Cytochrome c oxidase polypeptide 7A1, mitochondrial",P24310,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
369,T3D0028,Cyanide,"Cytochrome c oxidase polypeptide 7A2, mitochondrial",P14406,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
370,T3D0028,Cyanide,"Cytochrome c oxidase subunit 7B, mitochondrial",P24311,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
371,T3D0028,Cyanide,"Cytochrome c oxidase subunit 7C, mitochondrial",P15954,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
372,T3D0028,Cyanide,"Cytochrome c oxidase subunit 8A, mitochondrial",P10176,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
373,T3D0028,Cyanide,Catalase,P04040,Cyanide inhibits catalase. (R211) 
376,T3D0028,Cyanide,Glutathione peroxidase 1,P07203,Cyanide inhibits glutathione peroxidases. (R212) 
377,T3D0028,Cyanide,Glutathione peroxidase 2,P18283,Cyanide inhibits glutathione peroxidases. (R212) 
378,T3D0028,Cyanide,Glutathione peroxidase 3,P22352,Cyanide inhibits glutathione peroxidases. (R212) 
379,T3D0028,Cyanide,"Phospholipid hydroperoxide glutathione peroxidase, mitochondrial",P36969,Cyanide inhibits glutathione peroxidases. (R212) 
380,T3D0028,Cyanide,Epididymal secretory glutathione peroxidase,O75715,Cyanide inhibits glutathione peroxidases. (R212) 
381,T3D0028,Cyanide,Glutathione peroxidase 6,P59796,Cyanide inhibits glutathione peroxidases. (R212) 
382,T3D0028,Cyanide,Tyrosinase,P14679,Cyanide inhibits tyrosinase. (R214) 
386,T3D0029,Aroclor 1242,Aryl hydrocarbon receptor,P35869,"Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. (R015) "
387,T3D0029,Aroclor 1242,Estrogen sulfotransferase,P49888,"PCBs can cause endocrine disurption by binding to estrogen sulfotransferase, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. (R013, R203) "
388,T3D0029,Aroclor 1242,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
397,T3D0029,Aroclor 1242,Uteroglobin,P11684,PCBs will bioaccumulate by binding to receptor proteins such as uteroglobin. (R071)
413,T3D0031,Toxaphene,Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
414,T3D0031,Toxaphene,Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
415,T3D0031,Toxaphene,Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
416,T3D0031,Toxaphene,Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
417,T3D0031,Toxaphene,Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
418,T3D0031,Toxaphene,Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
419,T3D0031,Toxaphene,Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
420,T3D0031,Toxaphene,Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
421,T3D0031,Toxaphene,Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
422,T3D0031,Toxaphene,Gamma-aminobutyric acid receptor subunit delta,O14764,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
423,T3D0031,Toxaphene,Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
424,T3D0031,Toxaphene,Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
425,T3D0031,Toxaphene,Gamma-aminobutyric acid receptor subunit pi,O00591,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
426,T3D0031,Toxaphene,Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
427,T3D0031,Toxaphene,Gamma-aminobutyric acid receptor subunit rho-2,P28476,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
428,T3D0031,Toxaphene,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
429,T3D0031,Toxaphene,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
430,T3D0031,Toxaphene,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
431,T3D0031,Toxaphene,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
432,T3D0031,Toxaphene,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
433,T3D0031,Toxaphene,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
434,T3D0031,Toxaphene,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
435,T3D0031,Toxaphene,Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
436,T3D0031,Toxaphene,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
437,T3D0031,Toxaphene,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
438,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
439,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
440,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
441,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
442,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
443,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
444,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
445,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
446,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
447,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric acid receptor subunit delta,O14764,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
448,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
449,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
450,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric acid receptor subunit pi,O00591,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
451,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
452,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric acid receptor subunit rho-2,P28476,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
453,T3D0032,"Hexachlorocyclohexane, gamma-",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
454,T3D0032,"Hexachlorocyclohexane, gamma-",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
455,T3D0032,"Hexachlorocyclohexane, gamma-",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
456,T3D0032,"Hexachlorocyclohexane, gamma-",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
457,T3D0032,"Hexachlorocyclohexane, gamma-",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
458,T3D0032,"Hexachlorocyclohexane, gamma-",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
459,T3D0032,"Hexachlorocyclohexane, gamma-",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
460,T3D0032,"Hexachlorocyclohexane, gamma-",Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
461,T3D0032,"Hexachlorocyclohexane, gamma-",Estrogen-related receptor gamma,P62508,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting estrogen-related receptor gamma. (R188)
462,T3D0032,"Hexachlorocyclohexane, gamma-",Androgen receptor,P10275,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting the androgen receptor. (R188)
463,T3D0032,"Hexachlorocyclohexane, gamma-",Progesterone receptor,P06401,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting the progesterone receptor. (R188)
464,T3D0033,Tetrachloroethylene,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
465,T3D0033,Tetrachloroethylene,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
466,T3D0033,Tetrachloroethylene,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
467,T3D0033,Tetrachloroethylene,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
468,T3D0033,Tetrachloroethylene,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
469,T3D0033,Tetrachloroethylene,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
470,T3D0033,Tetrachloroethylene,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
471,T3D0033,Tetrachloroethylene,Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
472,T3D0033,Tetrachloroethylene,Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
473,T3D0033,Tetrachloroethylene,Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
474,T3D0033,Tetrachloroethylene,Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
475,T3D0033,Tetrachloroethylene,Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
476,T3D0033,Tetrachloroethylene,Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
477,T3D0033,Tetrachloroethylene,Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
478,T3D0033,Tetrachloroethylene,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
479,T3D0033,Tetrachloroethylene,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
480,T3D0033,Tetrachloroethylene,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
481,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
482,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
483,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
484,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
485,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
486,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
487,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
488,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
489,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
490,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric acid receptor subunit delta,O14764,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
491,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
492,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
493,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric acid receptor subunit pi,O00591,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
494,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
495,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric acid receptor subunit rho-2,P28476,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
496,T3D0036,"Hexachlorocyclohexane, beta-",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
497,T3D0036,"Hexachlorocyclohexane, beta-",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
498,T3D0036,"Hexachlorocyclohexane, beta-",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
499,T3D0036,"Hexachlorocyclohexane, beta-",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
500,T3D0036,"Hexachlorocyclohexane, beta-",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
501,T3D0036,"Hexachlorocyclohexane, beta-",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
502,T3D0036,"Hexachlorocyclohexane, beta-",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
503,T3D0036,"Hexachlorocyclohexane, beta-",Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
504,T3D0036,"Hexachlorocyclohexane, beta-",Estrogen-related receptor gamma,P62508,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting estrogen-related receptor gamma. (R188)
505,T3D0036,"Hexachlorocyclohexane, beta-",Androgen receptor,P10275,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting the androgen receptor. (R188)
506,T3D0036,"Hexachlorocyclohexane, beta-",Progesterone receptor,P06401,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting the progesterone receptor. (R188)
508,T3D0039,Benzo[a]anthracene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
509,T3D0039,Benzo[a]anthracene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
510,T3D0041,Endrin,Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
511,T3D0041,Endrin,Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
512,T3D0041,Endrin,Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
513,T3D0041,Endrin,Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
514,T3D0041,Endrin,Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
515,T3D0041,Endrin,Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
516,T3D0041,Endrin,Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
517,T3D0041,Endrin,Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
518,T3D0041,Endrin,Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
519,T3D0041,Endrin,Gamma-aminobutyric acid receptor subunit delta,O14764,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
520,T3D0041,Endrin,Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
521,T3D0041,Endrin,Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
522,T3D0041,Endrin,Gamma-aminobutyric acid receptor subunit pi,O00591,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
523,T3D0041,Endrin,Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
524,T3D0041,Endrin,Gamma-aminobutyric acid receptor subunit rho-2,P28476,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
525,T3D0041,Endrin,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
526,T3D0041,Endrin,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
527,T3D0041,Endrin,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
528,T3D0041,Endrin,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
529,T3D0041,Endrin,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
530,T3D0041,Endrin,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
531,T3D0041,Endrin,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
532,T3D0041,Endrin,Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
533,T3D0041,Endrin,Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
534,T3D0041,Endrin,Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
535,T3D0041,Endrin,Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
536,T3D0041,Endrin,Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
537,T3D0041,Endrin,Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
538,T3D0041,Endrin,Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
539,T3D0041,Endrin,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
540,T3D0041,Endrin,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
541,T3D0041,Endrin,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
543,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
544,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
545,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
546,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
547,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
548,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
549,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
550,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
551,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
552,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric acid receptor subunit delta,O14764,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
553,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
554,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
555,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric acid receptor subunit pi,O00591,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
556,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
557,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric acid receptor subunit rho-2,P28476,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
558,T3D0043,"Hexachlorocyclohexane, delta-",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
559,T3D0043,"Hexachlorocyclohexane, delta-",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
560,T3D0043,"Hexachlorocyclohexane, delta-",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
561,T3D0043,"Hexachlorocyclohexane, delta-",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
562,T3D0043,"Hexachlorocyclohexane, delta-",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
563,T3D0043,"Hexachlorocyclohexane, delta-",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
564,T3D0043,"Hexachlorocyclohexane, delta-",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
565,T3D0043,"Hexachlorocyclohexane, delta-",Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
566,T3D0043,"Hexachlorocyclohexane, delta-",Estrogen-related receptor gamma,P62508,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting estrogen-related receptor gamma. (R188)
567,T3D0043,"Hexachlorocyclohexane, delta-",Androgen receptor,P10275,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting the androgen receptor. (R188)
568,T3D0043,"Hexachlorocyclohexane, delta-",Progesterone receptor,P06401,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting the progesterone receptor. (R188)
569,T3D0048,Aroclor 1221,Aryl hydrocarbon receptor,P35869,"Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. (R015)"
570,T3D0048,Aroclor 1221,Estrogen sulfotransferase,P49888,"PCBs can cause endocrine disurption by binding to estrogen sulfotransferase, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. (R013, R203)"
571,T3D0048,Aroclor 1221,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
580,T3D0048,Aroclor 1221,Uteroglobin,P11684,PCBs will bioaccumulate by binding to receptor proteins such as uteroglobin. (R071)
581,T3D0049,Cobalt,Carbonic anhydrase 1,P00915,"Cobalt inhibits carbonic anhydrases.(R086, R248)"
583,T3D0050,"DDT, O,P'-",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
584,T3D0050,"DDT, O,P'-",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
585,T3D0050,"DDT, O,P'-",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
586,T3D0050,"DDT, O,P'-",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
587,T3D0050,"DDT, O,P'-",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
588,T3D0050,"DDT, O,P'-",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
589,T3D0050,"DDT, O,P'-",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
590,T3D0050,"DDT, O,P'-",Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
591,T3D0050,"DDT, O,P'-",Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
592,T3D0050,"DDT, O,P'-",Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
593,T3D0050,"DDT, O,P'-",Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
594,T3D0050,"DDT, O,P'-",Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
595,T3D0050,"DDT, O,P'-",Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
596,T3D0050,"DDT, O,P'-",Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
597,T3D0050,"DDT, O,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
598,T3D0050,"DDT, O,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
599,T3D0050,"DDT, O,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
600,T3D0050,"DDT, O,P'-",Calmodulin,P62158,"DDT inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
601,T3D0050,"DDT, O,P'-",Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
602,T3D0050,"DDT, O,P'-",Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
603,T3D0050,"DDT, O,P'-",Androgen receptor,P10275,DDT is also believed to adversely affect the reproductive system by mimicking endogenous hormones and binding to the estrogen and adrogen receptors. (R153)
604,T3D0051,Aroclor 1016,Aryl hydrocarbon receptor,P35869,"Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. (R015)"
605,T3D0051,Aroclor 1016,Estrogen sulfotransferase,P49888,"PCBs can cause endocrine disurption by binding to estrogen sulfotransferase, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. (R013, R203)"
606,T3D0051,Aroclor 1016,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
615,T3D0051,Aroclor 1016,Uteroglobin,P11684,PCBs will bioaccumulate by binding to receptor proteins such as uteroglobin. (R071)
616,T3D0053,Nickel,Calcineurin subunit B type 1,P63098,"Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. (R100)"
617,T3D0053,Nickel,Histone H4,P62805,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
618,T3D0053,Nickel,Histone H3.1,P68431,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
619,T3D0053,Nickel,Histone H3.1t,Q16695,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
620,T3D0053,Nickel,Histone H3.3,P84243,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
621,T3D0053,Nickel,Protamine-2,P04554,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
625,T3D0054,Endosulfan,Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
626,T3D0054,Endosulfan,Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
627,T3D0054,Endosulfan,Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
628,T3D0054,Endosulfan,Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
629,T3D0054,Endosulfan,Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
630,T3D0054,Endosulfan,Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
631,T3D0054,Endosulfan,Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
632,T3D0054,Endosulfan,Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
633,T3D0054,Endosulfan,Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
634,T3D0054,Endosulfan,Gamma-aminobutyric acid receptor subunit delta,O14764,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
635,T3D0054,Endosulfan,Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
636,T3D0054,Endosulfan,Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
637,T3D0054,Endosulfan,Gamma-aminobutyric acid receptor subunit pi,O00591,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
638,T3D0054,Endosulfan,Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
639,T3D0054,Endosulfan,Gamma-aminobutyric acid receptor subunit rho-2,P28476,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
640,T3D0054,Endosulfan,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
641,T3D0054,Endosulfan,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
642,T3D0054,Endosulfan,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
643,T3D0054,Endosulfan,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
644,T3D0054,Endosulfan,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
645,T3D0054,Endosulfan,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
646,T3D0054,Endosulfan,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
647,T3D0054,Endosulfan,Sodium/potassium-transporting ATPase gamma chain,P54710,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
648,T3D0054,Endosulfan,Calcium-transporting ATPase type 2C member 1,P98194,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
649,T3D0054,Endosulfan,Calcium-transporting ATPase type 2C member 2,O75185,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
650,T3D0054,Endosulfan,Plasma membrane calcium-transporting ATPase 1,P20020,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
651,T3D0054,Endosulfan,Plasma membrane calcium-transporting ATPase 2,Q01814,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
652,T3D0054,Endosulfan,Plasma membrane calcium-transporting ATPase 3,Q16720,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
653,T3D0054,Endosulfan,Plasma membrane calcium-transporting ATPase 4,P23634,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
654,T3D0054,Endosulfan,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
655,T3D0054,Endosulfan,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
656,T3D0054,Endosulfan,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
657,T3D0054,Endosulfan,Progesterone receptor,P06401,Endosulfan is an endocrine disruptor and acts as an agonist at the progesterone receptor. (R312)
658,T3D0054,Endosulfan,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
659,T3D0054,Endosulfan,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
660,T3D0055,Endosulfan sulfate,Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
661,T3D0055,Endosulfan sulfate,Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
662,T3D0055,Endosulfan sulfate,Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
663,T3D0055,Endosulfan sulfate,Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
664,T3D0055,Endosulfan sulfate,Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
665,T3D0055,Endosulfan sulfate,Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
666,T3D0055,Endosulfan sulfate,Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
667,T3D0055,Endosulfan sulfate,Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
668,T3D0055,Endosulfan sulfate,Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
669,T3D0055,Endosulfan sulfate,Gamma-aminobutyric acid receptor subunit delta,O14764,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
670,T3D0055,Endosulfan sulfate,Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
671,T3D0055,Endosulfan sulfate,Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
672,T3D0055,Endosulfan sulfate,Gamma-aminobutyric acid receptor subunit pi,O00591,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
673,T3D0055,Endosulfan sulfate,Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
674,T3D0055,Endosulfan sulfate,Gamma-aminobutyric acid receptor subunit rho-2,P28476,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
675,T3D0055,Endosulfan sulfate,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
676,T3D0055,Endosulfan sulfate,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
677,T3D0055,Endosulfan sulfate,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
678,T3D0055,Endosulfan sulfate,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
679,T3D0055,Endosulfan sulfate,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
680,T3D0055,Endosulfan sulfate,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
681,T3D0055,Endosulfan sulfate,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
682,T3D0055,Endosulfan sulfate,Sodium/potassium-transporting ATPase gamma chain,P54710,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
683,T3D0055,Endosulfan sulfate,Calcium-transporting ATPase type 2C member 1,P98194,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
684,T3D0055,Endosulfan sulfate,Calcium-transporting ATPase type 2C member 2,O75185,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
685,T3D0055,Endosulfan sulfate,Plasma membrane calcium-transporting ATPase 1,P20020,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
686,T3D0055,Endosulfan sulfate,Plasma membrane calcium-transporting ATPase 2,Q01814,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
687,T3D0055,Endosulfan sulfate,Plasma membrane calcium-transporting ATPase 3,Q16720,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
688,T3D0055,Endosulfan sulfate,Plasma membrane calcium-transporting ATPase 4,P23634,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
689,T3D0055,Endosulfan sulfate,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
690,T3D0055,Endosulfan sulfate,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
691,T3D0055,Endosulfan sulfate,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"Endosulfan sulfate inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
692,T3D0055,Endosulfan sulfate,Progesterone receptor,P06401,Endosulfan sulfate is an endocrine disruptor and acts as an agonist at the progesterone receptor. (R312)
693,T3D0055,Endosulfan sulfate,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
694,T3D0055,Endosulfan sulfate,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
695,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
696,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
697,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
698,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
699,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
700,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
701,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
702,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
703,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
704,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric acid receptor subunit delta,O14764,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
705,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
706,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
707,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric acid receptor subunit pi,O00591,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
708,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
709,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric acid receptor subunit rho-2,P28476,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
710,T3D0057,"Endosulfan, alpha",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
711,T3D0057,"Endosulfan, alpha",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
712,T3D0057,"Endosulfan, alpha",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
713,T3D0057,"Endosulfan, alpha",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
714,T3D0057,"Endosulfan, alpha",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
715,T3D0057,"Endosulfan, alpha",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
716,T3D0057,"Endosulfan, alpha",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
717,T3D0057,"Endosulfan, alpha",Sodium/potassium-transporting ATPase gamma chain,P54710,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
718,T3D0057,"Endosulfan, alpha",Calcium-transporting ATPase type 2C member 1,P98194,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
719,T3D0057,"Endosulfan, alpha",Calcium-transporting ATPase type 2C member 2,O75185,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
720,T3D0057,"Endosulfan, alpha",Plasma membrane calcium-transporting ATPase 1,P20020,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
721,T3D0057,"Endosulfan, alpha",Plasma membrane calcium-transporting ATPase 2,Q01814,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
722,T3D0057,"Endosulfan, alpha",Plasma membrane calcium-transporting ATPase 3,Q16720,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
723,T3D0057,"Endosulfan, alpha",Plasma membrane calcium-transporting ATPase 4,P23634,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
724,T3D0057,"Endosulfan, alpha",Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
725,T3D0057,"Endosulfan, alpha",Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
726,T3D0057,"Endosulfan, alpha",Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
727,T3D0057,"Endosulfan, alpha",Progesterone receptor,P06401,Endosulfan is an endocrine disruptor and acts as an agonist at the progesterone receptor. (R312)
728,T3D0057,"Endosulfan, alpha",Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
729,T3D0057,"Endosulfan, alpha",Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
730,T3D0060,Dibromochloropropane,NADH-ubiquinone oxidoreductase chain 1,P03886,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
731,T3D0061,Methoxychlor,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
732,T3D0061,Methoxychlor,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
733,T3D0061,Methoxychlor,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
734,T3D0061,Methoxychlor,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
735,T3D0061,Methoxychlor,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
736,T3D0061,Methoxychlor,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
737,T3D0061,Methoxychlor,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
738,T3D0061,Methoxychlor,Sodium/potassium-transporting ATPase gamma chain,P54710,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
739,T3D0061,Methoxychlor,Calcium-transporting ATPase type 2C member 1,P98194,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
740,T3D0061,Methoxychlor,Calcium-transporting ATPase type 2C member 2,O75185,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
741,T3D0061,Methoxychlor,Plasma membrane calcium-transporting ATPase 1,P20020,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
742,T3D0061,Methoxychlor,Plasma membrane calcium-transporting ATPase 2,Q01814,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
743,T3D0061,Methoxychlor,Plasma membrane calcium-transporting ATPase 3,Q16720,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
744,T3D0061,Methoxychlor,Plasma membrane calcium-transporting ATPase 4,P23634,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
745,T3D0061,Methoxychlor,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
746,T3D0061,Methoxychlor,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
747,T3D0061,Methoxychlor,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029, R325)"
749,T3D0062,Benzo[k]fluoranthene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
750,T3D0062,Benzo[k]fluoranthene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
751,T3D0065,Chromium(VI) oxide,Mitogen-activated protein kinase 1,P28482,Chromium has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. (R075)
752,T3D0065,Chromium(VI) oxide,Mitogen-activated protein kinase 3,P27361,Chromium has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. (R075)
753,T3D0065,Chromium(VI) oxide,Histone deacetylase 1,Q13547,"Chromium can cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. (R076)"
754,T3D0065,Chromium(VI) oxide,Metal regulatory transcription factor 1,Q14872,"Chromium may increase its own toxicity by modifying metal regulatory transcription factor 1, causing the inhibition of zinc-induced metallothionein transcription. (R077)"
755,T3D0067,"Endosulfan, beta",Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
756,T3D0067,"Endosulfan, beta",Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
757,T3D0067,"Endosulfan, beta",Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
758,T3D0067,"Endosulfan, beta",Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
759,T3D0067,"Endosulfan, beta",Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
760,T3D0067,"Endosulfan, beta",Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
761,T3D0067,"Endosulfan, beta",Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
762,T3D0067,"Endosulfan, beta",Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
763,T3D0067,"Endosulfan, beta",Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
764,T3D0067,"Endosulfan, beta",Gamma-aminobutyric acid receptor subunit delta,O14764,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
765,T3D0067,"Endosulfan, beta",Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
766,T3D0067,"Endosulfan, beta",Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
767,T3D0067,"Endosulfan, beta",Gamma-aminobutyric acid receptor subunit pi,O00591,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
768,T3D0067,"Endosulfan, beta",Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
769,T3D0067,"Endosulfan, beta",Gamma-aminobutyric acid receptor subunit rho-2,P28476,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
770,T3D0067,"Endosulfan, beta",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
771,T3D0067,"Endosulfan, beta",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
772,T3D0067,"Endosulfan, beta",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
773,T3D0067,"Endosulfan, beta",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
774,T3D0067,"Endosulfan, beta",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
775,T3D0067,"Endosulfan, beta",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
776,T3D0067,"Endosulfan, beta",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
777,T3D0067,"Endosulfan, beta",Sodium/potassium-transporting ATPase gamma chain,P54710,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
778,T3D0067,"Endosulfan, beta",Calcium-transporting ATPase type 2C member 1,P98194,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
779,T3D0067,"Endosulfan, beta",Calcium-transporting ATPase type 2C member 2,O75185,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
780,T3D0067,"Endosulfan, beta",Plasma membrane calcium-transporting ATPase 1,P20020,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
781,T3D0067,"Endosulfan, beta",Plasma membrane calcium-transporting ATPase 2,Q01814,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
782,T3D0067,"Endosulfan, beta",Plasma membrane calcium-transporting ATPase 3,Q16720,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
783,T3D0067,"Endosulfan, beta",Plasma membrane calcium-transporting ATPase 4,P23634,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
784,T3D0067,"Endosulfan, beta",Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
785,T3D0067,"Endosulfan, beta",Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
786,T3D0067,"Endosulfan, beta",Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"Endosulfan inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (R194)"
787,T3D0067,"Endosulfan, beta",Progesterone receptor,P06401,Endosulfan is an endocrine disruptor and acts as an agonist at the progesterone receptor. (R312)
788,T3D0067,"Endosulfan, beta",Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
789,T3D0067,"Endosulfan, beta",Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
792,T3D0068,Aroclor 1232,Aryl hydrocarbon receptor,P35869,"Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. (R015)"
793,T3D0068,Aroclor 1232,Estrogen sulfotransferase,P49888,"PCBs can cause endocrine disurption by binding to estrogen sulfotransferase, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. (R013, R203)"
794,T3D0068,Aroclor 1232,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
803,T3D0068,Aroclor 1232,Uteroglobin,P11684,PCBs will bioaccumulate by binding to receptor proteins such as uteroglobin. (R071)
805,T3D0070,Benzofluoranthene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
806,T3D0070,Benzofluoranthene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
807,T3D0074,Zinc,Superoxide dismutase [Cu-Zn],P00441,"Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). (R128)"
808,T3D0075,Dimethylarsinic acid,Hemoglobin subunit alpha,P69905,Arsenic binds to hemoglobin. (R052)
809,T3D0075,Dimethylarsinic acid,Hemoglobin subunit beta,P68871,Arsenic binds to hemoglobin. (R052)
817,T3D0077,Chromium,Mitogen-activated protein kinase 1,P28482,Chromium has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. (R075)
818,T3D0077,Chromium,Mitogen-activated protein kinase 3,P27361,Chromium has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. (R075)
819,T3D0077,Chromium,Histone deacetylase 1,Q13547,"Chromium can cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. (R076)"
820,T3D0077,Chromium,Metal regulatory transcription factor 1,Q14872,"Chromium may increase its own toxicity by modifying metal regulatory transcription factor 1, causing the inhibition of zinc-induced metallothionein transcription. (R077)"
822,T3D0078,Naphthalene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
823,T3D0078,Naphthalene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
824,T3D0081,Aroclor 1240,Aryl hydrocarbon receptor,P35869,"Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. (R015)"
825,T3D0081,Aroclor 1240,Estrogen sulfotransferase,P49888,"PCBs can cause endocrine disurption by binding to estrogen sulfotransferase, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. (R013, R203)"
826,T3D0081,Aroclor 1240,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
835,T3D0081,Aroclor 1240,Uteroglobin,P11684,PCBs will bioaccumulate by binding to receptor proteins such as uteroglobin. (R071)
840,T3D0093,Hexachlorobenzene,Uroporphyrinogen decarboxylase,P06132,"Hexachlorobenzene causes porphyria by modifying sulfhydryl groups in the catalytic or substrate-binding sites of uroporphyrinogen decarboxylase. This inhibits uroporphyrinogen decarboxylase, resulting in a deficiency of the decarboxylation of uroporphyrinogen III and accumulation of uroporphyrins in the liver. (R437)"
845,T3D0110,Fluoranthene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
846,T3D0110,Fluoranthene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
847,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
848,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
849,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
850,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
851,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
852,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
853,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
854,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
855,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
856,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric acid receptor subunit delta,O14764,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
857,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
858,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
859,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric acid receptor subunit pi,O00591,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
860,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
861,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric acid receptor subunit rho-2,P28476,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
862,T3D0115,"Hexachlorocyclohexane, alpha-",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
863,T3D0115,"Hexachlorocyclohexane, alpha-",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
864,T3D0115,"Hexachlorocyclohexane, alpha-",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
865,T3D0115,"Hexachlorocyclohexane, alpha-",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
866,T3D0115,"Hexachlorocyclohexane, alpha-",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
867,T3D0115,"Hexachlorocyclohexane, alpha-",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
868,T3D0115,"Hexachlorocyclohexane, alpha-",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
869,T3D0115,"Hexachlorocyclohexane, alpha-",Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
870,T3D0115,"Hexachlorocyclohexane, alpha-",Estrogen-related receptor gamma,P62508,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting estrogen-related receptor gamma. (R188)
871,T3D0115,"Hexachlorocyclohexane, alpha-",Androgen receptor,P10275,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting the androgen receptor. (R188)
872,T3D0115,"Hexachlorocyclohexane, alpha-",Progesterone receptor,P06401,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting the progesterone receptor. (R188)
874,T3D0123,Methylmercury,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
876,T3D0123,Methylmercury,Tubulin alpha-1B chain,P68363,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
877,T3D0123,Methylmercury,Tubulin alpha-3C/D chain,Q13748,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
878,T3D0123,Methylmercury,Tubulin alpha-4A chain,P68366,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
879,T3D0123,Methylmercury,Tubulin beta chain,P07437,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
880,T3D0123,Methylmercury,Tubulin beta-2A chain,Q13885,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
881,T3D0123,Methylmercury,Tubulin beta-2C chain,P68371,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
882,T3D0123,Methylmercury,Tubulin beta-3 chain,Q13509,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
883,T3D0123,Methylmercury,Tubulin beta-4 chain,P04350,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
884,T3D0123,Methylmercury,Tubulin gamma-1 chain,P23258,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
885,T3D0123,Methylmercury,Aquaporin-1,P29972,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
886,T3D0123,Methylmercury,Aquaporin-2,P41181,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
887,T3D0123,Methylmercury,Aquaporin-3,Q92482,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
888,T3D0123,Methylmercury,Aquaporin-4,P55087,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
889,T3D0123,Methylmercury,Aquaporin-5,P55064,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
890,T3D0123,Methylmercury,Aquaporin-6,Q13520,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
891,T3D0123,Methylmercury,Aquaporin-7,O14520,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
892,T3D0123,Methylmercury,Aquaporin-8,O94778,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
893,T3D0123,Methylmercury,Aquaporin-9,O43315,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
894,T3D0133,Hydrogen cyanide,Cytochrome c oxidase subunit 1,P00395,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
895,T3D0133,Hydrogen cyanide,Cytochrome c oxidase subunit 2,P00403,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
896,T3D0133,Hydrogen cyanide,Cytochrome c oxidase subunit 3,P00414,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
897,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial",P13073,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
898,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 5A, mitochondrial",P20674,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
899,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 5B, mitochondrial",P10606,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
900,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 6A1, mitochondrial",P12074,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
901,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 6A2, mitochondrial ",Q02221,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
902,T3D0133,Hydrogen cyanide,Cytochrome c oxidase subunit 6B1,P14854,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
903,T3D0133,Hydrogen cyanide,Cytochrome c oxidase subunit 6C,P09669,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
904,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase polypeptide 7A1, mitochondrial",P24310,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
905,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase polypeptide 7A2, mitochondrial",P14406,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
906,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 7B, mitochondrial",P24311,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
907,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 7C, mitochondrial",P15954,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
908,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 8A, mitochondrial",P10176,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
909,T3D0133,Hydrogen cyanide,Catalase,P04040,Cyanide inhibits catalase. (R211) 
912,T3D0133,Hydrogen cyanide,Glutathione peroxidase 1,P07203,Cyanide inhibits glutathione peroxidases. (R212) 
913,T3D0133,Hydrogen cyanide,Glutathione peroxidase 2,P18283,Cyanide inhibits glutathione peroxidases. (R212) 
914,T3D0133,Hydrogen cyanide,Glutathione peroxidase 3,P22352,Cyanide inhibits glutathione peroxidases. (R212) 
915,T3D0133,Hydrogen cyanide,"Phospholipid hydroperoxide glutathione peroxidase, mitochondrial",P36969,Cyanide inhibits glutathione peroxidases. (R212) 
916,T3D0133,Hydrogen cyanide,Epididymal secretory glutathione peroxidase,O75715,Cyanide inhibits glutathione peroxidases. (R212) 
917,T3D0133,Hydrogen cyanide,Glutathione peroxidase 6,P59796,Cyanide inhibits glutathione peroxidases. (R212) 
918,T3D0133,Hydrogen cyanide,Tyrosinase,P14679,Cyanide inhibits tyrosinase. (R214) 
920,T3D0137,Chrysene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
921,T3D0137,Chrysene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
922,T3D0144,Dicofol,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
923,T3D0144,Dicofol,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
924,T3D0144,Dicofol,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
925,T3D0144,Dicofol,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
926,T3D0144,Dicofol,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
927,T3D0144,Dicofol,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
928,T3D0144,Dicofol,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
929,T3D0144,Dicofol,Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
930,T3D0144,Dicofol,Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
931,T3D0144,Dicofol,Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
932,T3D0144,Dicofol,Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
933,T3D0144,Dicofol,Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
934,T3D0144,Dicofol,Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
935,T3D0144,Dicofol,Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
936,T3D0144,Dicofol,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
937,T3D0144,Dicofol,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
938,T3D0144,Dicofol,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
939,T3D0144,Dicofol,Calmodulin,P62158,"Difocol inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
940,T3D0144,Dicofol,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
942,T3D0144,Dicofol,Androgen receptor,P10275,Difocol is also an endocrine disruptor and binds both the androgen and estrogen receptor. (R966)
943,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
944,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
945,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
946,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
947,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
948,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
949,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
950,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
951,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
952,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric acid receptor subunit delta,O14764,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
953,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
954,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
955,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric acid receptor subunit pi,O00591,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
956,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
957,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric acid receptor subunit rho-2,P28476,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
958,T3D0148,"Hexachlorocyclohexane, technical Grade",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"Hexachlorocyclohexane inhibits sodium/potassium-transporting ATPases, reducing the rate of depolarization and increasing the sensitivity of neurons. (R186) "
959,T3D0148,"Hexachlorocyclohexane, technical Grade",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"Hexachlorocyclohexane inhibits sodium/potassium-transporting ATPases, reducing the rate of depolarization and increasing the sensitivity of neurons. (R186) "
960,T3D0148,"Hexachlorocyclohexane, technical Grade",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"Hexachlorocyclohexane inhibits sodium/potassium-transporting ATPases, reducing the rate of depolarization and increasing the sensitivity of neurons. (R186) "
961,T3D0148,"Hexachlorocyclohexane, technical Grade",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"Hexachlorocyclohexane inhibits sodium/potassium-transporting ATPases, reducing the rate of depolarization and increasing the sensitivity of neurons. (R186) "
962,T3D0148,"Hexachlorocyclohexane, technical Grade",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"Hexachlorocyclohexane inhibits sodium/potassium-transporting ATPases, reducing the rate of depolarization and increasing the sensitivity of neurons. (R186) "
963,T3D0148,"Hexachlorocyclohexane, technical Grade",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"Hexachlorocyclohexane inhibits sodium/potassium-transporting ATPases, reducing the rate of depolarization and increasing the sensitivity of neurons. (R186) "
964,T3D0148,"Hexachlorocyclohexane, technical Grade",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"Hexachlorocyclohexane inhibits sodium/potassium-transporting ATPases, reducing the rate of depolarization and increasing the sensitivity of neurons. (R186) "
965,T3D0148,"Hexachlorocyclohexane, technical Grade",Sodium/potassium-transporting ATPase gamma chain,P54710,"Hexachlorocyclohexane inhibits sodium/potassium-transporting ATPases, reducing the rate of depolarization and increasing the sensitivity of neurons. (R186) "
966,T3D0148,"Hexachlorocyclohexane, technical Grade",Estrogen-related receptor gamma,P62508,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting estrogen-related receptor gamma. (R188)
967,T3D0148,"Hexachlorocyclohexane, technical Grade",Androgen receptor,P10275,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting the androgen receptor. (R188)
968,T3D0148,"Hexachlorocyclohexane, technical Grade",Progesterone receptor,P06401,Hexachlorocyclohexane acts as an endocrine disruptor by inhibiting the progesterone receptor. (R188)
970,T3D0151,"DDD, O,P'-",Androgen receptor,P10275,DDD is also believed to adversely affect the reproductive system by mimicking endogenous hormones and binding to the estrogen and adrogen receptors. (R153) 
971,T3D0151,"DDD, O,P'-",Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
972,T3D0151,"DDD, O,P'-",Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
973,T3D0151,"DDD, O,P'-",Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
974,T3D0151,"DDD, O,P'-",Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
975,T3D0151,"DDD, O,P'-",Sodium/potassium-transporting ATPase subunit beta-1,P05026,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
976,T3D0151,"DDD, O,P'-",Sodium/potassium-transporting ATPase subunit beta-2,P14415,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
977,T3D0151,"DDD, O,P'-",Sodium/potassium-transporting ATPase subunit beta-3,P54709,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
978,T3D0151,"DDD, O,P'-",Sodium/potassium-transporting ATPase gamma chain,P54710,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
979,T3D0151,"DDD, O,P'-",Calcium-transporting ATPase type 2C member 1,P98194,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
980,T3D0151,"DDD, O,P'-",Calcium-transporting ATPase type 2C member 2,O75185,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
981,T3D0151,"DDD, O,P'-",Plasma membrane calcium-transporting ATPase 1,P20020,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
982,T3D0151,"DDD, O,P'-",Plasma membrane calcium-transporting ATPase 2,Q01814,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
983,T3D0151,"DDD, O,P'-",Plasma membrane calcium-transporting ATPase 3,Q16720,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
984,T3D0151,"DDD, O,P'-",Plasma membrane calcium-transporting ATPase 4,P23634,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
985,T3D0151,"DDD, O,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
986,T3D0151,"DDD, O,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
987,T3D0151,"DDD, O,P'-",Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
988,T3D0151,"DDD, O,P'-",Calmodulin,P62158,"DDD inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. This reduces the rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (R029) "
989,T3D0151,"DDD, O,P'-",Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
990,T3D0151,"DDD, O,P'-",Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
1014,T3D0158,2-Methylnaphthalene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1015,T3D0158,2-Methylnaphthalene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1017,T3D0161,Acenaphthene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1018,T3D0161,Acenaphthene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1020,T3D0174,"Indeno(1,2,3-cd)pyrene",Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1021,T3D0174,"Indeno(1,2,3-cd)pyrene",Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1022,T3D0215,Chromic acid,Mitogen-activated protein kinase 1,P28482,Chromium has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. (R075)
1023,T3D0215,Chromic acid,Mitogen-activated protein kinase 3,P27361,Chromium has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. (R075)
1024,T3D0215,Chromic acid,Histone deacetylase 1,Q13547,"Chromium can cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. (R076)"
1025,T3D0215,Chromic acid,Metal regulatory transcription factor 1,Q14872,"Chromium may increase its own toxicity by modifying metal regulatory transcription factor 1, causing the inhibition of zinc-induced metallothionein transcription. (R077)"
1026,T3D0223,Arsenic acid,"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial",P29803,"Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001)"
1027,T3D0223,Arsenic acid,Hemoglobin subunit beta,P68871,Arsenic binds to hemoglobin. (R052)
1028,T3D0223,Arsenic acid,Hemoglobin subunit alpha,P69905,Arsenic binds to hemoglobin. (R052)
1029,T3D0223,Arsenic acid,Haptoglobin,P00738,Arsenic binds to haptoglobin. (R052)
1030,T3D0223,Arsenic acid,Estrogen receptor,P03372,Arsenic binds to the estrogen receptor. (R054)
1031,T3D0223,Arsenic acid,Glucocorticoid receptor,P04150,Arsenic binds to the glucocorticoid receptor. (R054)
1032,T3D0223,Arsenic acid,"Glutathione reductase, mitochondrial",P00390,"Arsenic binds glutathione reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1033,T3D0223,Arsenic acid,Kelch-like ECH-associated protein 1,Q14145,Arsenic binds to kelch-like ECH-associated protein 1. (R054)
1034,T3D0223,Arsenic acid,Poly [ADP-ribose] polymerase 1,P09874,Arsenic binding of PARP-1 is believed to induce carcinogenesis by affecting DNA repair. (R054)
1036,T3D0223,Arsenic acid,Tubulin beta chain,P07437,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1037,T3D0223,Arsenic acid,"Actin, cytoplasmic 1",P60709,Arsenic binds to actin. (R053)
1038,T3D0223,Arsenic acid,"Actin, cytoplasmic 2",P63261,Arsenic binds to actin. (R053)
1040,T3D0224,Arsenic trioxide,"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial",P29803,"Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001)"
1041,T3D0224,Arsenic trioxide,Hemoglobin subunit beta,P68871,Arsenic binds to hemoglobin. (R052)
1042,T3D0224,Arsenic trioxide,Hemoglobin subunit alpha,P69905,Arsenic binds to hemoglobin. (R052)
1043,T3D0224,Arsenic trioxide,Haptoglobin,P00738,Arsenic binds to haptoglobin. (R052)
1044,T3D0224,Arsenic trioxide,Estrogen receptor,P03372,Arsenic binds to the estrogen receptor. (R054)
1045,T3D0224,Arsenic trioxide,Glucocorticoid receptor,P04150,Arsenic binds to the glucocorticoid receptor. (R054)
1046,T3D0224,Arsenic trioxide,"Glutathione reductase, mitochondrial",P00390,"Arsenic binds glutathione reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1047,T3D0224,Arsenic trioxide,Kelch-like ECH-associated protein 1,Q14145,Arsenic binds to kelch-like ECH-associated protein 1. (R054)
1048,T3D0224,Arsenic trioxide,Poly [ADP-ribose] polymerase 1,P09874,Arsenic binding of PARP-1 is believed to induce carcinogenesis by affecting DNA repair. (R054)
1050,T3D0224,Arsenic trioxide,Tubulin beta chain,P07437,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1051,T3D0224,Arsenic trioxide,"Actin, cytoplasmic 1",P60709,Arsenic binds to actin. (R053)
1052,T3D0224,Arsenic trioxide,"Actin, cytoplasmic 2",P63261,Arsenic binds to actin. (R053)
1053,T3D0224,Arsenic trioxide,"Thioredoxin reductase 1, cytoplasmic",Q16881,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1055,T3D0226,Benzo[e]pyrene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1056,T3D0226,Benzo[e]pyrene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1057,T3D0234,Arsine,Hemoglobin subunit alpha,P69905,"Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. (R030)"
1058,T3D0234,Arsine,Hemoglobin subunit beta,P68871,"Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. (R030)"
1059,T3D0234,Arsine,Hemoglobin subunit gamma-1,P69891,"Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. (R030)"
1060,T3D0234,Arsine,Hemoglobin subunit gamma-2,P69892,"Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. (R030)"
1061,T3D0234,Arsine,Hemoglobin subunit delta,P02042,"Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. (R030)"
1062,T3D0234,Arsine,Hemoglobin subunit epsilon,P02100,"Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. (R030)"
1063,T3D0234,Arsine,Hemoglobin subunit theta-1,P09105,"Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. (R030)"
1064,T3D0234,Arsine,Hemoglobin subunit zeta,P02008,"Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. (R030)"
1065,T3D0234,Arsine,Catalase,P04040,"Arsine may inhibit catalase, which leads to the accumulation of hydrogen peroxide. This destroys red cell membranes and may contribute to arsine-induced conversion of Fe+2 to Fe+3, which also impairs oxygen transport. (R030)"
1066,T3D0241,Calcium arsenate,"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial",P29803,"Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001)"
1067,T3D0241,Calcium arsenate,Hemoglobin subunit beta,P68871,Arsenic binds to hemoglobin. (R052)
1068,T3D0241,Calcium arsenate,Hemoglobin subunit alpha,P69905,Arsenic binds to hemoglobin. (R052)
1069,T3D0241,Calcium arsenate,Haptoglobin,P00738,Arsenic binds to haptoglobin. (R052)
1070,T3D0241,Calcium arsenate,Estrogen receptor,P03372,Arsenic binds to the estrogen receptor. (R054)
1071,T3D0241,Calcium arsenate,Glucocorticoid receptor,P04150,Arsenic binds to the glucocorticoid receptor. (R054)
1072,T3D0241,Calcium arsenate,"Glutathione reductase, mitochondrial",P00390,"Arsenic binds glutathione reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1073,T3D0241,Calcium arsenate,Kelch-like ECH-associated protein 1,Q14145,Arsenic binds to kelch-like ECH-associated protein 1. (R054)
1074,T3D0241,Calcium arsenate,Poly [ADP-ribose] polymerase 1,P09874,Arsenic binding of PARP-1 is believed to induce carcinogenesis by affecting DNA repair. (R054)
1076,T3D0241,Calcium arsenate,Tubulin beta chain,P07437,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1077,T3D0241,Calcium arsenate,"Actin, cytoplasmic 1",P60709,Arsenic binds to actin. (R053)
1078,T3D0241,Calcium arsenate,"Actin, cytoplasmic 2",P63261,Arsenic binds to actin. (R053)
1079,T3D0241,Calcium arsenate,"Thioredoxin reductase 1, cytoplasmic",Q16881,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1081,T3D0242,Mercuric chloride,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1083,T3D0242,Mercuric chloride,Tubulin alpha-1B chain,P68363,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1084,T3D0242,Mercuric chloride,Tubulin alpha-3C/D chain,Q13748,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1085,T3D0242,Mercuric chloride,Tubulin alpha-4A chain,P68366,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1086,T3D0242,Mercuric chloride,Tubulin beta chain,P07437,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1087,T3D0242,Mercuric chloride,Tubulin beta-2A chain,Q13885,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1088,T3D0242,Mercuric chloride,Tubulin beta-2C chain,P68371,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1089,T3D0242,Mercuric chloride,Tubulin beta-3 chain,Q13509,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1090,T3D0242,Mercuric chloride,Tubulin beta-4 chain,P04350,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1091,T3D0242,Mercuric chloride,Tubulin gamma-1 chain,P23258,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1092,T3D0242,Mercuric chloride,Aquaporin-1,P29972,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1093,T3D0242,Mercuric chloride,Aquaporin-2,P41181,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1094,T3D0242,Mercuric chloride,Aquaporin-3,Q92482,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1095,T3D0242,Mercuric chloride,Aquaporin-4,P55087,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1096,T3D0242,Mercuric chloride,Aquaporin-5,P55064,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1097,T3D0242,Mercuric chloride,Aquaporin-6,Q13520,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1098,T3D0242,Mercuric chloride,Aquaporin-7,O14520,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1099,T3D0242,Mercuric chloride,Aquaporin-8,O94778,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1100,T3D0242,Mercuric chloride,Aquaporin-9,O43315,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1101,T3D0243,Sodium arsenite,"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial",P29803,"Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001)"
1102,T3D0243,Sodium arsenite,Hemoglobin subunit beta,P68871,Arsenic binds to hemoglobin. (R052)
1103,T3D0243,Sodium arsenite,Hemoglobin subunit alpha,P69905,Arsenic binds to hemoglobin. (R052)
1104,T3D0243,Sodium arsenite,Haptoglobin,P00738,Arsenic binds to haptoglobin. (R052)
1105,T3D0243,Sodium arsenite,Estrogen receptor,P03372,Arsenic binds to the estrogen receptor. (R054)
1106,T3D0243,Sodium arsenite,Glucocorticoid receptor,P04150,Arsenic binds to the glucocorticoid receptor. (R054)
1107,T3D0243,Sodium arsenite,"Glutathione reductase, mitochondrial",P00390,"Arsenic binds glutathione reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1108,T3D0243,Sodium arsenite,Kelch-like ECH-associated protein 1,Q14145,Arsenic binds to kelch-like ECH-associated protein 1. (R054)
1109,T3D0243,Sodium arsenite,Poly [ADP-ribose] polymerase 1,P09874,Arsenic binding of PARP-1 is believed to induce carcinogenesis by affecting DNA repair. (R054)
1111,T3D0243,Sodium arsenite,Tubulin beta chain,P07437,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1112,T3D0243,Sodium arsenite,"Actin, cytoplasmic 1",P60709,Arsenic binds to actin. (R053)
1113,T3D0243,Sodium arsenite,"Actin, cytoplasmic 2",P63261,Arsenic binds to actin. (R053)
1114,T3D0243,Sodium arsenite,"Thioredoxin reductase 1, cytoplasmic",Q16881,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1116,T3D0246,Phenanthrene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1117,T3D0246,Phenanthrene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1119,T3D0253,Pyrene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1120,T3D0253,Pyrene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1122,T3D0340,Mercury(II) fulminate,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1124,T3D0341,Mercury(II) sulfide,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1126,T3D0342,Mercury(II) oxide,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1128,T3D0343,Mercury(I) chloride,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1130,T3D0344,Phenylmercuric acetate,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1132,T3D0345,Mercury selenide,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1134,T3D0346,Mercury telluride,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1136,T3D0347,Mercury cadmium telluride,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1138,T3D0348,Mercury(II) acetate,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1140,T3D0349,Mercury(I) acetate,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1142,T3D0350,Mercury(II) iodide,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1144,T3D0351,Mercury(I) iodide,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1146,T3D0352,Mercury(I) bromide,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1148,T3D0353,Mercury(II) bromide,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1150,T3D0354,Mercury(II) nitrate,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1152,T3D0355,Mercury(I) nitrate,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1153,T3D0356,Mercury(II) thiocyanate,Catalase,P04040,Cyanide inhibits catalase. (R211)
1154,T3D0356,Mercury(II) thiocyanate,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1156,T3D0357,Mercury(II) sulfate,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1158,T3D0358,Mercury(I) sulfate,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1160,T3D0360,Methylmercuric chloride,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1162,T3D0361,Dimethyl mercury,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1164,T3D0361,Dimethyl mercury,Tubulin alpha-1B chain,P68363,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1165,T3D0361,Dimethyl mercury,Tubulin alpha-3C/D chain,Q13748,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1166,T3D0361,Dimethyl mercury,Tubulin alpha-4A chain,P68366,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1167,T3D0361,Dimethyl mercury,Tubulin beta chain,P07437,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1168,T3D0361,Dimethyl mercury,Tubulin beta-2A chain,Q13885,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1169,T3D0361,Dimethyl mercury,Tubulin beta-2C chain,P68371,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1170,T3D0361,Dimethyl mercury,Tubulin beta-3 chain,Q13509,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1171,T3D0361,Dimethyl mercury,Tubulin beta-4 chain,P04350,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1172,T3D0361,Dimethyl mercury,Tubulin gamma-1 chain,P23258,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1173,T3D0361,Dimethyl mercury,Aquaporin-1,P29972,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1174,T3D0361,Dimethyl mercury,Aquaporin-2,P41181,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1175,T3D0361,Dimethyl mercury,Aquaporin-3,Q92482,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1176,T3D0361,Dimethyl mercury,Aquaporin-4,P55087,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1177,T3D0361,Dimethyl mercury,Aquaporin-5,P55064,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1178,T3D0361,Dimethyl mercury,Aquaporin-6,Q13520,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1179,T3D0361,Dimethyl mercury,Aquaporin-7,O14520,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1180,T3D0361,Dimethyl mercury,Aquaporin-8,O94778,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1181,T3D0361,Dimethyl mercury,Aquaporin-9,O43315,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1183,T3D0362,Mercuric potassium iodide,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1184,T3D0363,Mercury(II) cyanide,Catalase,P04040,Cyanide inhibits catalase. (R211)
1185,T3D0363,Mercury(II) cyanide,Proto-oncogene tyrosine-protein kinase LCK,P06239,"Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)"
1186,T3D0616,Methiochlor,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1187,T3D0616,Methiochlor,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1188,T3D0616,Methiochlor,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1189,T3D0616,Methiochlor,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1190,T3D0616,Methiochlor,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1191,T3D0616,Methiochlor,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1192,T3D0616,Methiochlor,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1193,T3D0616,Methiochlor,Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1194,T3D0616,Methiochlor,Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1195,T3D0616,Methiochlor,Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1196,T3D0616,Methiochlor,Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1197,T3D0616,Methiochlor,Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1198,T3D0616,Methiochlor,Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1199,T3D0616,Methiochlor,Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1200,T3D0616,Methiochlor,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1201,T3D0616,Methiochlor,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1202,T3D0616,Methiochlor,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1203,T3D0617,Chlorbenzylate,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1204,T3D0617,Chlorbenzylate,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1205,T3D0617,Chlorbenzylate,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1206,T3D0617,Chlorbenzylate,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1207,T3D0617,Chlorbenzylate,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1208,T3D0617,Chlorbenzylate,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1209,T3D0617,Chlorbenzylate,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1210,T3D0617,Chlorbenzylate,Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1211,T3D0617,Chlorbenzylate,Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1212,T3D0617,Chlorbenzylate,Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1213,T3D0617,Chlorbenzylate,Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1214,T3D0617,Chlorbenzylate,Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1215,T3D0617,Chlorbenzylate,Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1216,T3D0617,Chlorbenzylate,Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1217,T3D0617,Chlorbenzylate,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1218,T3D0617,Chlorbenzylate,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1219,T3D0617,Chlorbenzylate,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1220,T3D0628,1-Methylnaphthalene,Cellular tumor antigen p53,P04637,1-Methylnaphthalene binds to cellular tumor antigen p53.
1221,T3D0628,1-Methylnaphthalene,Aryl hydrocarbon receptor,P35869,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1222,T3D0628,1-Methylnaphthalene,Glycine N-methyltransferase,Q14749,"Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073)"
1225,T3D0752,Chloral hydrate,Alcohol dehydrogenase 1A,P07327,
1226,T3D0752,Chloral hydrate,Alcohol dehydrogenase 1B,P00325,
1227,T3D0752,Chloral hydrate,Alcohol dehydrogenase 1C,P00326,
1228,T3D0752,Chloral hydrate,Alcohol dehydrogenase class 4 mu/sigma chain,P40394,
1229,T3D0752,Chloral hydrate,Alcohol dehydrogenase class-3,P11766,
1230,T3D0752,Chloral hydrate,Alcohol dehydrogenase 4,P08319,
1231,T3D0752,Chloral hydrate,Alcohol dehydrogenase 6,P28332,
1248,T3D0123,Methylmercury,Tubulin alpha-1A chain,Q71U36,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1249,T3D0123,Methylmercury,Tubulin alpha-1C chain,Q9BQE3,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1250,T3D0123,Methylmercury,Tubulin alpha-3E chain,Q6PEY2,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1251,T3D0123,Methylmercury,Tubulin beta-1 chain,Q9H4B7,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1252,T3D0123,Methylmercury,Tubulin beta-2B chain,Q9BVA1,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1253,T3D0123,Methylmercury,Tubulin alpha-8 chain,Q9NY65,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1254,T3D0123,Methylmercury,Tubulin beta-8 chain,Q3ZCM7,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1255,T3D0123,Methylmercury,Tubulin beta-6 chain,Q9BUF5,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1256,T3D0123,Methylmercury,Tubulin delta chain,Q9UJT1,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1257,T3D0123,Methylmercury,Tubulin epsilon chain,Q9UJT0,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1258,T3D0123,Methylmercury,Tubulin gamma-2 chain,Q9NRH3,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1259,T3D0123,Methylmercury,Aquaporin-10,Q96PS8,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1260,T3D0123,Methylmercury,Aquaporin-11,Q8NBQ7,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1261,T3D0123,Methylmercury,Aquaporin-12A,Q8IXF9,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1262,T3D0242,Mercuric chloride,Aquaporin-10,Q96PS8,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1263,T3D0242,Mercuric chloride,Aquaporin-11,Q8NBQ7,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1264,T3D0242,Mercuric chloride,Aquaporin-12A,Q8IXF9,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1265,T3D0242,Mercuric chloride,Tubulin alpha-1A chain,Q71U36,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1266,T3D0242,Mercuric chloride,Tubulin alpha-1C chain,Q9BQE3,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1267,T3D0242,Mercuric chloride,Tubulin alpha-3E chain,Q6PEY2,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1268,T3D0242,Mercuric chloride,Tubulin alpha-8 chain,Q9NY65,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1269,T3D0242,Mercuric chloride,Tubulin beta-1 chain,Q9H4B7,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1270,T3D0242,Mercuric chloride,Tubulin beta-2B chain,Q9BVA1,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1271,T3D0242,Mercuric chloride,Tubulin beta-6 chain,Q9BUF5,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1272,T3D0242,Mercuric chloride,Tubulin beta-8 chain,Q3ZCM7,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1273,T3D0242,Mercuric chloride,Tubulin delta chain,Q9UJT1,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1274,T3D0242,Mercuric chloride,Tubulin epsilon chain,Q9UJT0,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1275,T3D0242,Mercuric chloride,Tubulin gamma-2 chain,Q9NRH3,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1276,T3D0361,Dimethyl mercury,Aquaporin-10,Q96PS8,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1277,T3D0361,Dimethyl mercury,Aquaporin-11,Q8NBQ7,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1278,T3D0361,Dimethyl mercury,Aquaporin-12A,Q8IXF9,"Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)"
1279,T3D0361,Dimethyl mercury,Tubulin alpha-1A chain,Q71U36,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1280,T3D0361,Dimethyl mercury,Tubulin alpha-1C chain,Q9BQE3,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1281,T3D0361,Dimethyl mercury,Tubulin alpha-3E chain,Q6PEY2,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1282,T3D0361,Dimethyl mercury,Tubulin alpha-8 chain,Q9NY65,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1283,T3D0361,Dimethyl mercury,Tubulin beta-1 chain,Q9H4B7,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1284,T3D0361,Dimethyl mercury,Tubulin beta-2B chain,Q9BVA1,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1285,T3D0361,Dimethyl mercury,Tubulin beta-6 chain,Q9BUF5,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1286,T3D0361,Dimethyl mercury,Tubulin beta-8 chain,Q3ZCM7,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1287,T3D0361,Dimethyl mercury,Tubulin delta chain,Q9UJT1,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1288,T3D0361,Dimethyl mercury,Tubulin epsilon chain,Q9UJT0,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1289,T3D0361,Dimethyl mercury,Tubulin gamma-2 chain,Q9NRH3,"Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)"
1290,T3D0006,Benzene,Tubulin alpha-1A chain,Q71U36,Direct binding of tubulin leads to protein damage. (R016)
1291,T3D0006,Benzene,Tubulin alpha-1C chain,Q9BQE3,Direct binding of tubulin leads to protein damage. (R016)
1292,T3D0006,Benzene,Tubulin alpha-3E chain,Q6PEY2,Direct binding of tubulin leads to protein damage. (R016)
1293,T3D0006,Benzene,Tubulin alpha-8 chain,Q9NY65,Direct binding of tubulin leads to protein damage. (R016)
1294,T3D0006,Benzene,Tubulin beta-1 chain,Q9H4B7,Direct binding of tubulin leads to protein damage. (R016)
1295,T3D0006,Benzene,Tubulin beta-2B chain,Q9BVA1,Direct binding of tubulin leads to protein damage. (R016)
1296,T3D0006,Benzene,Tubulin beta-6 chain,Q9BUF5,Direct binding of tubulin leads to protein damage. (R016)
1297,T3D0006,Benzene,Tubulin beta-8 chain,Q3ZCM7,Direct binding of tubulin leads to protein damage. (R016)
1298,T3D0006,Benzene,Tubulin delta chain,Q9UJT1,Direct binding of tubulin leads to protein damage. (R016)
1299,T3D0006,Benzene,Tubulin epsilon chain,Q9UJT0,Direct binding of tubulin leads to protein damage. (R016)
1300,T3D0006,Benzene,Tubulin gamma-2 chain,Q9NRH3,Direct binding of tubulin leads to protein damage. (R016)
1301,T3D0053,Nickel,Histone H3.2,Q71DI3,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1302,T3D0006,Benzene,Histone H3.2,Q71DI3,Direct binding of histone leads to protein damage. (R016)
1303,T3D0006,Benzene,Ribonucleoside-diphosphate reductase subunit M2 B,Q7LG56,Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)
1305,T3D0007,Cadmium,C-jun-amino-terminal kinase-interacting protein 1,Q9UQF2,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
1306,T3D0007,Cadmium,C-jun-amino-terminal kinase-interacting protein 3,Q9UPT6,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
1307,T3D0006,Benzene,"DNA polymerase subunit gamma-2, mitochondrial",Q9UHN1,Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)
1308,T3D0011,Chloroform,Potassium voltage-gated channel subfamily H member 6,Q9H252,"Chloroform has been shown to block HERG potassium channels, causing cardiac arrest. (R070)"
1309,T3D0011,Chloroform,Potassium voltage-gated channel subfamily H member 7,Q9NS40,"Chloroform has been shown to block HERG potassium channels, causing cardiac arrest. (R070)"
1310,T3D0053,Nickel,Calcineurin subunit B isoform 2,Q96LZ3,"Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. (R100)"
1311,T3D0007,Cadmium,Mitogen-activated protein kinase 15,Q8TD08,Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
1312,T3D0002,Lead,Glutamate [NMDA] receptor subunit 3A,Q8TCU5,"Lead exhibits competitive inhibition at the NMDA receptor, affecting neurotransmitter release. (R063)"
1313,T3D0071,Toluene,Sodium channel subunit beta-1,Q07699,"Toluene binds to cardiac Na+ channels in the open state and unbinds either when channels move between inactivated states or from an inactivated to a closed state. The use- and frequency-dependent block of Na+ by toluene might be responsible, at least in part, for its arrhythmogenic effect. (R201)"
1314,T3D0071,Toluene,Sodium channel subunit beta-2,O60939,"Toluene binds to cardiac Na+ channels in the open state and unbinds either when channels move between inactivated states or from an inactivated to a closed state. The use- and frequency-dependent block of Na+ by toluene might be responsible, at least in part, for its arrhythmogenic effect. (R201)"
1315,T3D0071,Toluene,Sodium channel subunit beta-3,Q9NY72,"Toluene binds to cardiac Na+ channels in the open state and unbinds either when channels move between inactivated states or from an inactivated to a closed state. The use- and frequency-dependent block of Na+ by toluene might be responsible, at least in part, for its arrhythmogenic effect. (R201)"
1316,T3D0071,Toluene,Sodium channel subunit beta-4,Q8IWT1,"Toluene binds to cardiac Na+ channels in the open state and unbinds either when channels move between inactivated states or from an inactivated to a closed state. The use- and frequency-dependent block of Na+ by toluene might be responsible, at least in part, for its arrhythmogenic effect. (R201)"
1317,T3D0028,Cyanide,Cytochrome c oxidase subunit 6B2,Q6YFQ2,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
1318,T3D0028,Cyanide,"Cytochrome c oxidase subunit 4 isoform 2, mitochondrial",Q96KJ9,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
1319,T3D0028,Cyanide,"Cytochrome c oxidase subunit 7B2, mitochondrial ",Q8TF08,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
1320,T3D0028,Cyanide,"Cytochrome c oxidase subunit 8C, mitochondrial",Q7Z4L0,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
1321,T3D0133,Hydrogen cyanide,Cytochrome c oxidase subunit 6B2,Q6YFQ2,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
1322,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 4 isoform 2, mitochondrial",Q96KJ9,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
1323,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 7B2, mitochondrial ",Q8TF08,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
1324,T3D0133,Hydrogen cyanide,"Cytochrome c oxidase subunit 8C, mitochondrial",Q7Z4L0,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
1325,T3D0031,Toxaphene,Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1326,T3D0031,Toxaphene,Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1327,T3D0031,Toxaphene,Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1328,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1329,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1330,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1331,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1332,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1333,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1334,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1335,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1336,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1337,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1338,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1339,T3D0115,"Hexachlorocyclohexane, alpha-",Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1340,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
1341,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
1342,T3D0148,"Hexachlorocyclohexane, technical Grade",Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. (R186)"
1343,T3D0024,Aldrin,Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1344,T3D0024,Aldrin,Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1345,T3D0024,Aldrin,Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1346,T3D0041,Endrin,Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1347,T3D0041,Endrin,Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1348,T3D0041,Endrin,Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1349,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1350,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1351,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1352,T3D0054,Endosulfan,Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1353,T3D0054,Endosulfan,Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1354,T3D0054,Endosulfan,Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1355,T3D0067,"Endosulfan, beta",Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1356,T3D0067,"Endosulfan, beta",Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1357,T3D0067,"Endosulfan, beta",Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1358,T3D0055,Endosulfan sulfate,Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1359,T3D0055,Endosulfan sulfate,Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1360,T3D0055,Endosulfan sulfate,Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1362,T3D0234,Arsine,Hemoglobin subunit mu,Q6B0K9,"Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. (R030)"
1371,T3D0243,Sodium arsenite,"Thioredoxin reductase 2, mitochondrial",Q9NNW7,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1372,T3D0243,Sodium arsenite,Thioredoxin reductase 3,Q86VQ6,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1373,T3D0223,Arsenic acid,"Thioredoxin reductase 2, mitochondrial",Q9NNW7,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1374,T3D0223,Arsenic acid,Thioredoxin reductase 3,Q86VQ6,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1375,T3D0224,Arsenic trioxide,"Thioredoxin reductase 2, mitochondrial",Q9NNW7,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1376,T3D0224,Arsenic trioxide,Thioredoxin reductase 3,Q86VQ6,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1377,T3D0241,Calcium arsenate,"Thioredoxin reductase 2, mitochondrial",Q9NNW7,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1378,T3D0241,Calcium arsenate,Thioredoxin reductase 3,Q86VQ6,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1379,T3D0001,Arsenic,"Thioredoxin reductase 2, mitochondrial",Q9NNW7,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1380,T3D0001,Arsenic,Thioredoxin reductase 3,Q86VQ6,"Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)"
1381,T3D0012,"DDT, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Q9UL51,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1382,T3D0012,"DDT, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Q9Y3Q4,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1383,T3D0021,"DDE, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Q9UL51,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1384,T3D0021,"DDE, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Q9Y3Q4,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1385,T3D0025,"DDD, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Q9UL51,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1386,T3D0025,"DDD, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Q9Y3Q4,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1387,T3D0050,"DDT, O,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Q9UL51,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1388,T3D0050,"DDT, O,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Q9Y3Q4,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1389,T3D0144,Dicofol,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Q9Y3Q4,"Difocol inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1390,T3D0144,Dicofol,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Q9UL51,"Difocol inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1391,T3D0151,"DDD, O,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Q9UL51,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1392,T3D0151,"DDD, O,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Q9Y3Q4,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1395,T3D0061,Methoxychlor,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Q9UL51,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1396,T3D0061,Methoxychlor,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Q9Y3Q4,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1410,T3D0028,Cyanide,Glutathione peroxidase 7,Q96SL4,Cyanide inhibits glutathione peroxidases. (R212) 
1411,T3D0133,Hydrogen cyanide,Glutathione peroxidase 7,Q96SL4,Cyanide inhibits glutathione peroxidases. (R212) 
1412,T3D0012,"DDT, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,O60741,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1413,T3D0012,"DDT, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,Q9P1Z3 ,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1414,T3D0144,Dicofol,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,O60741,"Difocol inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1415,T3D0144,Dicofol,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,Q9P1Z3 ,"Difocol inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1418,T3D0021,"DDE, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,O60741,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1419,T3D0021,"DDE, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,Q9P1Z3 ,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1420,T3D0025,"DDD, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,O60741,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1421,T3D0025,"DDD, P,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,Q9P1Z3 ,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1422,T3D0050,"DDT, O,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,O60741,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1423,T3D0050,"DDT, O,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,Q9P1Z3 ,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1424,T3D0151,"DDD, O,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,O60741,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1425,T3D0151,"DDD, O,P'-",Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,Q9P1Z3 ,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1426,T3D0061,Methoxychlor,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,O60741,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1427,T3D0061,Methoxychlor,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,Q9P1Z3 ,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1428,T3D0616,Methiochlor,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,O60741,"Methiochlor inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1429,T3D0616,Methiochlor,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Q9UL51,"Methiochlor inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1430,T3D0616,Methiochlor,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,Q9P1Z3 ,"Methiochlor inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1431,T3D0616,Methiochlor,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Q9Y3Q4,"Methiochlor inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1432,T3D0617,Chlorbenzylate,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,O60741,Chlorobenzilate binds to Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1.
1433,T3D0617,Chlorbenzylate,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Q9UL51,Chlorobenzilate binds to Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2.
1434,T3D0617,Chlorbenzylate,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,Q9P1Z3 ,Chlorobenzilate binds to Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.
1435,T3D0617,Chlorbenzylate,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Q9Y3Q4,Chlorobenzilate binds to Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.
1436,T3D0001,Arsenic,DNA repair protein complementing XP-A cells,P23025,Arsenic binding of XPA is believed to induce carcinogenesis by affecting DNA repair. (R054)
1437,T3D0026,Benzidine,Hemoglobin subunit alpha,P69905,Benzidine has been shown to bind hemoglobin. (R169)
1438,T3D0026,Benzidine,Hemoglobin subunit beta,P68871,Benzidine has been shown to bind hemoglobin. (R169)
1439,T3D0026,Benzidine,Hemoglobin subunit delta,P02042,Benzidine has been shown to bind hemoglobin. (R169)
1440,T3D0026,Benzidine,Hemoglobin subunit epsilon,P02100,Benzidine has been shown to bind hemoglobin. (R169)
1441,T3D0026,Benzidine,Hemoglobin subunit gamma-1,P69891,Benzidine has been shown to bind hemoglobin. (R169)
1442,T3D0026,Benzidine,Hemoglobin subunit gamma-2,P69892,Benzidine has been shown to bind hemoglobin. (R169)
1443,T3D0026,Benzidine,Hemoglobin subunit mu,Q6B0K9,Benzidine has been shown to bind hemoglobin. (R169)
1444,T3D0026,Benzidine,Hemoglobin subunit theta-1,P09105,Benzidine has been shown to bind hemoglobin. (R169)
1445,T3D0026,Benzidine,Hemoglobin subunit zeta,P02008,Benzidine has been shown to bind hemoglobin. (R169)
1457,T3D0001,Arsenic,Tubulin alpha-1A chain,Q71U36,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1458,T3D0001,Arsenic,Tubulin alpha-1B chain,P68363,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1459,T3D0001,Arsenic,Tubulin alpha-1C chain,Q9BQE3,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1460,T3D0001,Arsenic,Tubulin alpha-3C/D chain,Q13748,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1461,T3D0001,Arsenic,Tubulin alpha-3E chain,Q6PEY2,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1462,T3D0001,Arsenic,Tubulin alpha-4A chain,P68366,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1463,T3D0001,Arsenic,Tubulin alpha-8 chain,Q9NY65,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1464,T3D0001,Arsenic,Tubulin beta-1 chain,Q9H4B7,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1465,T3D0001,Arsenic,Tubulin beta-2A chain,Q13885,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1466,T3D0001,Arsenic,Tubulin beta-2B chain,Q9BVA1,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1467,T3D0001,Arsenic,Tubulin beta-2C chain,P68371,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1468,T3D0001,Arsenic,Tubulin beta-3 chain,Q13509,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1469,T3D0001,Arsenic,Tubulin beta-4 chain,P04350,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1470,T3D0001,Arsenic,Tubulin beta-6 chain,Q9BUF5,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1471,T3D0001,Arsenic,Tubulin beta-8 chain,Q3ZCM7,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1472,T3D0001,Arsenic,"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial",P10515,"Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001)"
1473,T3D0001,Arsenic,"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial",P08559,"Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001)"
1474,T3D0001,Arsenic,"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial",P11177,"Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001)"
1475,T3D0001,Arsenic,"Pyruvate dehydrogenase protein X component, mitochondrial",O00330,"Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001)"
1477,T3D0001,Arsenic,"Actin, cytoplasmic 1",P60709,Arsenic binds to actin. (R053)
1478,T3D0001,Arsenic,"Actin, cytoplasmic 2",P63261,Arsenic binds to actin. (R053)
1479,T3D0005,Polychlorinated biphenyls,Aromatic-L-amino-acid decarboxylase,P20711,PCB inhibition of aromatic-L-amino-acid decarboxylase is believed to cause decreased dopamine synthesis. (R012)
1480,T3D0005,Polychlorinated biphenyls,Tyrosine 3-monooxygenase,P07101,PCB inhibition of tyrosine 3-monooxygenase is believed to cause decreased dopamine synthesis. (R012)
1481,T3D0005,Polychlorinated biphenyls,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
1482,T3D0013,Aroclor 1254,Aromatic-L-amino-acid decarboxylase,P20711,PCB inhibition of aromatic-L-amino-acid decarboxylase is believed to cause decreased dopamine synthesis. (R012)
1483,T3D0013,Aroclor 1254,Tyrosine 3-monooxygenase,P07101,PCB inhibition of tyrosine 3-monooxygenase is believed to cause decreased dopamine synthesis. (R012)
1484,T3D0013,Aroclor 1254,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
1485,T3D0014,Aroclor 1260,Aromatic-L-amino-acid decarboxylase,P20711,PCB inhibition of aromatic-L-amino-acid decarboxylase is believed to cause decreased dopamine synthesis. (R012)
1486,T3D0014,Aroclor 1260,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
1487,T3D0014,Aroclor 1260,Tyrosine 3-monooxygenase,P07101,PCB inhibition of tyrosine 3-monooxygenase is believed to cause decreased dopamine synthesis. (R012)
1488,T3D0016,Trichloroethylene,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial",Q15120,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase. (R160)"
1489,T3D0016,Trichloroethylene,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial",Q16654,"The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase. (R160)"
1490,T3D0020,Chlordane,Cytochrome P450 2B6,P20813,"Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (R159, R205)"
1492,T3D0020,Chlordane,Cytochrome P450 3A4,P08684,"Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (R159, R205)"
1493,T3D0020,Chlordane,Cytochrome P450 3A43,Q9HB55,"Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (R159, R205)"
1494,T3D0020,Chlordane,Cytochrome P450 3A5,P20815,"Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (R159, R205)"
1495,T3D0020,Chlordane,Cytochrome P450 3A7,P24462,"Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (R159, R205)"
1496,T3D0020,Chlordane,"Alkaline phosphatase, tissue-nonspecific isozyme",P05186,Chlordane inhibit alkaline phosphatases in hepatic and renal tissues. (R206)
1497,T3D0019,"Phosphorus, white",Leptin,P41159,Phosphorus may enhance deposition of calcium by activating leptin. (R207)
1499,T3D0019,"Phosphorus, white",Sodium-dependent phosphate transporter 1,Q8WUM9,Phosphorus may enhance deposition of calcium by activating sodium-dependent phosphate transporter 1. (R207)
1501,T3D0022,Hexachlorobutadiene,Apolipoprotein D,P05090,The binding of hexachlorobutadiene to alpha 2u-globulin is believed to be an important factor in its nephrotoxicity. (R167)
1502,T3D0027,Aroclor 1248,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
1503,T3D0027,Aroclor 1248,Tyrosine 3-monooxygenase,P07101,PCB inhibition of tyrosine 3-monooxygenase is believed to cause decreased dopamine synthesis. (R012) 
1504,T3D0027,Aroclor 1248,Aromatic-L-amino-acid decarboxylase,P20711,PCB inhibition of aromatic-L-amino-acid decarboxylase is believed to cause decreased dopamine synthesis. (R012) 
1506,T3D0029,Aroclor 1242,Aromatic-L-amino-acid decarboxylase,P20711,PCB inhibition of aromatic-L-amino-acid decarboxylase is believed to cause decreased dopamine synthesis. (R012) 
1508,T3D0029,Aroclor 1242,Tyrosine 3-monooxygenase,P07101,PCB inhibition of tyrosine 3-monooxygenase is believed to cause decreased dopamine synthesis. (R012) 
1510,T3D0029,Aroclor 1242,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
1511,T3D0028,Cyanide,Superoxide dismutase [Cu-Zn],P00441,Cyanide inhibits superoxide dismutase [Cu-Zn]. (R209)
1512,T3D0028,Cyanide,"Alkaline phosphatase, tissue-nonspecific isozyme",P05186,Cyanide inhibits alkaline phosphatases. (R210)
1514,T3D0028,Cyanide,"Alkaline phosphatase, placental-like",P10696,Cyanide inhibits alkaline phosphatases. (R210)
1516,T3D0028,Cyanide,"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial",Q99643,Cyanide inhibits succinate dehydrogenases. (R213) 
1517,T3D0028,Cyanide,"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial",O14521,Cyanide inhibits succinate dehydrogenases. (R213) 
1518,T3D0028,Cyanide,"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",P31040,Cyanide inhibits succinate dehydrogenases. (R213) 
1519,T3D0028,Cyanide,"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial",P21912,Cyanide inhibits succinate dehydrogenases. (R213) 
1520,T3D0028,Cyanide,"Glutathione reductase, mitochondrial",P00390,Cyanide inhibits glutathione reductase. (R213)
1521,T3D0031,Toxaphene,Calcium-transporting ATPase type 2C member 1,P98194,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1522,T3D0031,Toxaphene,Calcium-transporting ATPase type 2C member 2,O75185,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1523,T3D0031,Toxaphene,Plasma membrane calcium-transporting ATPase 1,P20020,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1524,T3D0031,Toxaphene,Plasma membrane calcium-transporting ATPase 2,Q01814,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1525,T3D0031,Toxaphene,Plasma membrane calcium-transporting ATPase 3,Q16720,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1526,T3D0031,Toxaphene,Plasma membrane calcium-transporting ATPase 4,P23634,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1527,T3D0031,Toxaphene,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,O14983,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1528,T3D0031,Toxaphene,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,P16615,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1529,T3D0031,Toxaphene,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3,Q93084,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1530,T3D0031,Toxaphene,Adenylate cyclase type 1,Q08828,"Toxaphene inhibits adenylate cyclase, which affects the sensitivity of the nervous system by altering calcium transport across cell membranes. (R216)"
1531,T3D0031,Toxaphene,Adenylate cyclase type 10,Q96PN6,"Toxaphene inhibits adenylate cyclase, which affects the sensitivity of the nervous system by altering calcium transport across cell membranes. (R216)"
1532,T3D0031,Toxaphene,Adenylate cyclase type 2,Q08462,"Toxaphene inhibits adenylate cyclase, which affects the sensitivity of the nervous system by altering calcium transport across cell membranes. (R216)"
1533,T3D0031,Toxaphene,Adenylate cyclase type 3,O60266,"Toxaphene inhibits adenylate cyclase, which affects the sensitivity of the nervous system by altering calcium transport across cell membranes. (R216)"
1534,T3D0031,Toxaphene,Adenylate cyclase type 4,Q8NFM4,"Toxaphene inhibits adenylate cyclase, which affects the sensitivity of the nervous system by altering calcium transport across cell membranes. (R216)"
1535,T3D0031,Toxaphene,Adenylate cyclase type 5,O95622,"Toxaphene inhibits adenylate cyclase, which affects the sensitivity of the nervous system by altering calcium transport across cell membranes. (R216)"
1536,T3D0031,Toxaphene,Adenylate cyclase type 6,O43306,"Toxaphene inhibits adenylate cyclase, which affects the sensitivity of the nervous system by altering calcium transport across cell membranes. (R216)"
1537,T3D0031,Toxaphene,Adenylate cyclase type 7,P51828,"Toxaphene inhibits adenylate cyclase, which affects the sensitivity of the nervous system by altering calcium transport across cell membranes. (R216)"
1538,T3D0031,Toxaphene,Adenylate cyclase type 8,P40145,"Toxaphene inhibits adenylate cyclase, which affects the sensitivity of the nervous system by altering calcium transport across cell membranes. (R216)"
1539,T3D0031,Toxaphene,Adenylate cyclase type 9,O60503,"Toxaphene inhibits adenylate cyclase, which affects the sensitivity of the nervous system by altering calcium transport across cell membranes. (R216)"
1540,T3D0031,Toxaphene,Acetylcholinesterase,P22303,"Toxapehene inhibits acetylcholinesterase, which affects the sensitivity of the nervous system. (R217)"
1541,T3D0034,Heptachlor,Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1542,T3D0034,Heptachlor,Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1543,T3D0034,Heptachlor,Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1544,T3D0034,Heptachlor,Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1545,T3D0034,Heptachlor,Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1546,T3D0034,Heptachlor,Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1547,T3D0034,Heptachlor,Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1548,T3D0034,Heptachlor,Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1549,T3D0034,Heptachlor,Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1550,T3D0034,Heptachlor,Gamma-aminobutyric acid receptor subunit delta,O14764,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1551,T3D0034,Heptachlor,Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1552,T3D0034,Heptachlor,Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1553,T3D0034,Heptachlor,Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1554,T3D0034,Heptachlor,Gamma-aminobutyric acid receptor subunit pi,O00591,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1555,T3D0034,Heptachlor,Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1556,T3D0034,Heptachlor,Gamma-aminobutyric acid receptor subunit rho-2,P28476,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1557,T3D0034,Heptachlor,Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1558,T3D0034,Heptachlor,Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1559,T3D0035,"1,2-Dibromoethane",Serum albumin,P02768,"1,2-Dibromoethane binds to serum albumin. (R223)"
1561,T3D0037,Acrolein,Inhibitor of nuclear factor kappa-B kinase subunit alpha,O15111,"Perturbation of inflammatory responses in bronchial epithelial cells was demonstrated by direct action of acrolein on the inhibitor of nuclear factor kappa-B (IκB) kinase, which inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor and suppresses interleukin 8 (IL-8) production. (R223)"
1562,T3D0037,Acrolein,Inhibitor of nuclear factor kappa-B kinase subunit beta,O14920,"Perturbation of inflammatory responses in bronchial epithelial cells was demonstrated by direct action of acrolein on the inhibitor of nuclear factor kappa-B (IκB) kinase, which inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor and suppresses interleukin 8 (IL-8) production. (R223)"
1563,T3D0037,Acrolein,Inhibitor of nuclear factor kappa-B kinase subunit epsilon,Q14164,"Perturbation of inflammatory responses in bronchial epithelial cells was demonstrated by direct action of acrolein on the inhibitor of nuclear factor kappa-B (IκB) kinase, which inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor and suppresses interleukin 8 (IL-8) production. (R223)"
1564,T3D0037,Acrolein,Thioredoxin,P10599,"Acrolein inhibits thioredoxin, which disrupts the cellular thiol redox balance necessary for cell survival. (R226)"
1565,T3D0037,Acrolein,"Thioredoxin, mitochondrial",Q99757,"Acrolein inhibits thioredoxin, which disrupts the cellular thiol redox balance necessary for cell survival. (R226)"
1566,T3D0037,Acrolein,"Thioredoxin reductase 1, cytoplasmic",Q16881,"Acrolein inhibits thioredoxin reductase, which disrupts the cellular thiol redox balance necessary for cell survival. (R226)"
1567,T3D0037,Acrolein,"Thioredoxin reductase 2, mitochondrial",Q9NNW7,"Acrolein inhibits thioredoxin reductase, which disrupts the cellular thiol redox balance necessary for cell survival. (R226)"
1568,T3D0037,Acrolein,Thioredoxin reductase 3,Q86VQ6,"Acrolein inhibits thioredoxin reductase, which disrupts the cellular thiol redox balance necessary for cell survival. (R226)"
1569,T3D0037,Acrolein,Apolipoprotein A-I,P02647,Acrolein interferes with normal reverse cholesterol transport by high density lipoprotein (HDL) by modifying specific sites in apolipoprotein A-I. (R228)
1570,T3D0037,Acrolein,Aldehyde dehydrogenase 1A3,P47895,Acrolein inhibits aldehyde dehydrogenases. (R227)
1571,T3D0037,Acrolein,Fatty aldehyde dehydrogenase,P51648,Acrolein inhibits aldehyde dehydrogenases. (R227)
1572,T3D0037,Acrolein,"Aldehyde dehydrogenase, dimeric NADP-preferring",P30838,Acrolein inhibits aldehyde dehydrogenases. (R227)
1573,T3D0037,Acrolein,Retinal dehydrogenase 1,P00352,Acrolein inhibits aldehyde dehydrogenases. (R227)
1574,T3D0037,Acrolein,Retinal dehydrogenase 2,O94788,Acrolein inhibits aldehyde dehydrogenases. (R227)
1575,T3D0037,Acrolein,Aldehyde dehydrogenase family 3 member B1,P43353,Acrolein inhibits aldehyde dehydrogenases. (R227)
1576,T3D0037,Acrolein,Aldehyde dehydrogenase family 3 member B2,P48448,Acrolein inhibits aldehyde dehydrogenases. (R227)
1577,T3D0037,Acrolein,"Aldehyde dehydrogenase X, mitochondrial",P30837,Acrolein inhibits aldehyde dehydrogenases. (R227)
1578,T3D0037,Acrolein,10-formyltetrahydrofolate dehydrogenase,O75891,Acrolein inhibits aldehyde dehydrogenases. (R227)
1579,T3D0037,Acrolein,Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2,Q3SY69,Acrolein inhibits aldehyde dehydrogenases. (R227)
1580,T3D0037,Acrolein,Transient receptor potential cation channel subfamily A member 1,O75762,"Acrolein activates the transient receptor potential cation channel, causing acute pain. (R229)"
1581,T3D0038,Disulfoton,Acetylcholinesterase,P22303,"The toxic metabolites of disulfoton, mainly disulfoton sulfoxide, disulfoton sulfone, demeton S-sulfoxide and demeton S-sulfone, inhibit acetylcholinesterase in nervous tissue. The inhibition of acetylcholinesterase results in the accumulation of acetylcholine at the muscarinic and nicotinic cholinergic receptors of nerve synapses, which causes an overstimulation of cholinergic nerves and effector organs. (R230)"
1583,T3D0040,"3,3'-Dichlorobenzidine",Hemoglobin subunit alpha,P69905,"3,3’-Dichlorobenzidine`s mechanism of toxicity derivies mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. (R232, R233)"
1584,T3D0040,"3,3'-Dichlorobenzidine",Hemoglobin subunit beta,P68871,"3,3’-Dichlorobenzidine`s mechanism of toxicity derivies mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. (R232, R233)"
1585,T3D0040,"3,3'-Dichlorobenzidine",Hemoglobin subunit delta,P02042,"3,3’-Dichlorobenzidine`s mechanism of toxicity derivies mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. (R232, R233)"
1586,T3D0040,"3,3'-Dichlorobenzidine",Hemoglobin subunit epsilon,P02100,"3,3’-Dichlorobenzidine`s mechanism of toxicity derivies mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. (R232, R233)"
1587,T3D0040,"3,3'-Dichlorobenzidine",Hemoglobin subunit gamma-1,P69891,"3,3’-Dichlorobenzidine`s mechanism of toxicity derivies mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. (R232, R233)"
1588,T3D0040,"3,3'-Dichlorobenzidine",Hemoglobin subunit gamma-2,P69892,"3,3’-Dichlorobenzidine`s mechanism of toxicity derivies mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. (R232, R233)"
1589,T3D0040,"3,3'-Dichlorobenzidine",Hemoglobin subunit mu,Q6B0K9,"3,3’-Dichlorobenzidine`s mechanism of toxicity derivies mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. (R232, R233)"
1590,T3D0040,"3,3'-Dichlorobenzidine",Hemoglobin subunit theta-1,P09105,"3,3’-Dichlorobenzidine`s mechanism of toxicity derivies mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. (R232, R233)"
1591,T3D0040,"3,3'-Dichlorobenzidine",Hemoglobin subunit zeta,P02008,"3,3’-Dichlorobenzidine`s mechanism of toxicity derivies mainly from the adduction of DNA by its metabolites. The formation of nitroso derivatives during metabolism, yielding a sulfinic acid amide with hemoglobin in erythrocytes, is suggested to be a mechanism for this adduct formation. (R232, R233)"
1592,T3D0040,"3,3'-Dichlorobenzidine",Aryl hydrocarbon receptor,P35869,"3,3’-Dichlorobenzidine acts on the aryl hydrocarbon receptor to induce the activity of cytochrome p-450 enzymes, which metabolize 3,3’-dichlorobenzidine, along with other polyhalogenated aromatics, into their toxic intermediates. (R234)"
1593,T3D0046,Heptachlor epoxide,Gamma-aminobutyric-acid receptor subunit alpha-1,P14867,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1594,T3D0046,Heptachlor epoxide,Gamma-aminobutyric-acid receptor subunit alpha-2,P47869,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1595,T3D0046,Heptachlor epoxide,Gamma-aminobutyric-acid receptor subunit alpha-3,P34903,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1596,T3D0046,Heptachlor epoxide,Gamma-aminobutyric-acid receptor subunit alpha-4,P48169,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1597,T3D0046,Heptachlor epoxide,Gamma-aminobutyric-acid receptor subunit alpha-5,P31644,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1598,T3D0046,Heptachlor epoxide,Gamma-aminobutyric-acid receptor subunit alpha-6,Q16445,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1599,T3D0046,Heptachlor epoxide,Gamma-aminobutyric-acid receptor subunit beta-1,P18505,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1600,T3D0046,Heptachlor epoxide,Gamma-aminobutyric-acid receptor subunit beta-2,P47870,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1601,T3D0046,Heptachlor epoxide,Gamma-aminobutyric-acid receptor subunit beta-3,P28472,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1602,T3D0046,Heptachlor epoxide,Gamma-aminobutyric acid receptor subunit delta,O14764,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1603,T3D0046,Heptachlor epoxide,Gamma-aminobutyric acid receptor subunit gamma-1,Q8N1C3,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1604,T3D0046,Heptachlor epoxide,Gamma-aminobutyric acid receptor subunit gamma-2,P18507,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1605,T3D0046,Heptachlor epoxide,Gamma-aminobutyric acid receptor subunit gamma-3,Q99928,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1606,T3D0046,Heptachlor epoxide,Gamma-aminobutyric acid receptor subunit pi,O00591,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1607,T3D0046,Heptachlor epoxide,Gamma-aminobutyric-acid receptor subunit rho-1,P24046,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1608,T3D0046,Heptachlor epoxide,Gamma-aminobutyric acid receptor subunit rho-2,P28476,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1609,T3D0046,Heptachlor epoxide,Gamma-aminobutyric acid receptor subunit rho-3,A8MPY1,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1610,T3D0046,Heptachlor epoxide,Gamma-aminobutyric acid receptor subunit theta,Q9UN88,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1611,T3D0048,Aroclor 1221,Aromatic-L-amino-acid decarboxylase,P20711,PCB inhibition of aromatic-L-amino-acid decarboxylase is believed to cause decreased dopamine synthesis. (R012)
1612,T3D0051,Aroclor 1016,Aromatic-L-amino-acid decarboxylase,P20711,PCB inhibition of aromatic-L-amino-acid decarboxylase is believed to cause decreased dopamine synthesis. (R012)
1613,T3D0048,Aroclor 1221,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
1614,T3D0051,Aroclor 1016,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
1615,T3D0048,Aroclor 1221,Tyrosine 3-monooxygenase,P07101,PCB inhibition of tyrosine 3-monooxygenase is believed to cause decreased dopamine synthesis. (R012)
1616,T3D0051,Aroclor 1016,Tyrosine 3-monooxygenase,P07101,PCB inhibition of tyrosine 3-monooxygenase is believed to cause decreased dopamine synthesis. (R012)
1617,T3D0042,Beryllium,"HLA class II histocompatibility antigen, DP alpha chain",P20036,"Once in the body, beryllium acts as a hapten and interacts with human leucocyte antigen (HLA) DP presenting cells in the lungs, becoming physically associated with a major histocompatability (MHC) class II molecule. This MHC class II-beryllium-peptide complex is recognized by the T lymphocyte receptor, triggering CD4+ T lymphocyte activation and proliferation. The resulting inflammatory response is a cell-mediated process orchestrated by cytokines and results in the formation of (usually pulmonary) granulomas. (R079, R083)"
1618,T3D0042,Beryllium,"HLA class II histocompatibility antigen, DP(W2) beta chain",P13763,"Once in the body, beryllium acts as a hapten and interacts with human leucocyte antigen (HLA) DP presenting cells in the lungs, becoming physically associated with a major histocompatability (MHC) class II molecule. This MHC class II-beryllium-peptide complex is recognized by the T lymphocyte receptor, triggering CD4+ T lymphocyte activation and proliferation. The resulting inflammatory response is a cell-mediated process orchestrated by cytokines and results in the formation of (usually pulmonary) granulomas. (R079, R083)"
1619,T3D0042,Beryllium,"HLA class II histocompatibility antigen, DP(W4) beta chain",P04440,"Once in the body, beryllium acts as a hapten and interacts with human leucocyte antigen (HLA) DP presenting cells in the lungs, becoming physically associated with a major histocompatability (MHC) class II molecule. This MHC class II-beryllium-peptide complex is recognized by the T lymphocyte receptor, triggering CD4+ T lymphocyte activation and proliferation. The resulting inflammatory response is a cell-mediated process orchestrated by cytokines and results in the formation of (usually pulmonary) granulomas. (R079, R083)"
1620,T3D0044,"1,2-Dibromo-3-chloropropane","NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial",P49821,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1621,T3D0044,"1,2-Dibromo-3-chloropropane","NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial",P19404,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1622,T3D0044,"1,2-Dibromo-3-chloropropane","NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial",P56181,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1623,T3D0044,"1,2-Dibromo-3-chloropropane","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial",O75306,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1624,T3D0044,"1,2-Dibromo-3-chloropropane","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial",O75489,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1625,T3D0044,"1,2-Dibromo-3-chloropropane","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial",O43181,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1626,T3D0044,"1,2-Dibromo-3-chloropropane",NADH dehydrogenase [ubiquinone] iron-sulfur protein 5,O43920,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1627,T3D0044,"1,2-Dibromo-3-chloropropane","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial",O75380,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1628,T3D0044,"1,2-Dibromo-3-chloropropane","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial",O75251,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1629,T3D0044,"1,2-Dibromo-3-chloropropane","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial",O00217,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1630,T3D0044,"1,2-Dibromo-3-chloropropane","NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial",P28331,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1631,T3D0044,"1,2-Dibromo-3-chloropropane",NADH-ubiquinone oxidoreductase chain 1,P03886,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1632,T3D0044,"1,2-Dibromo-3-chloropropane",NADH-ubiquinone oxidoreductase chain 2,P03891,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1633,T3D0044,"1,2-Dibromo-3-chloropropane",NADH-ubiquinone oxidoreductase chain 3,P03897,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1634,T3D0044,"1,2-Dibromo-3-chloropropane",NADH-ubiquinone oxidoreductase chain 4,P03905,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1635,T3D0044,"1,2-Dibromo-3-chloropropane",NADH-ubiquinone oxidoreductase chain 4L,P03901,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1636,T3D0044,"1,2-Dibromo-3-chloropropane",NADH-ubiquinone oxidoreductase chain 5,P03915,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1637,T3D0044,"1,2-Dibromo-3-chloropropane",NADH-ubiquinone oxidoreductase chain 6,P03923,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1638,T3D0045,Pentachlorophenol,Sulfotransferase 1A1,P50225,Pentachlorophenol prevents sulfation by inhibiting phenol-sulfotransferases. (R241)
1639,T3D0045,Pentachlorophenol,Sulfotransferase 1A2,P50226,Pentachlorophenol prevents sulfation by inhibiting phenol-sulfotransferases. (R241)
1640,T3D0045,Pentachlorophenol,Sulfotransferase 1A3/1A4,P50224,Pentachlorophenol prevents sulfation by inhibiting phenol-sulfotransferases. (R241)
1641,T3D0045,Pentachlorophenol,Acetylcholinesterase,P22303,Pentachlorophenol inhibits acetylcholinesterase in erythrocyte membranes. (R242)
1642,T3D0045,Pentachlorophenol,Transthyretin,P02766,Pentachlorophenol competes with thyroxine for uptake into cerebrospinal fluid at the T4 binding site of transthyretin. (R239)
1643,T3D0045,Pentachlorophenol,Carnitine O-acetyltransferase,P43155,Pentachlorophenol inhibits O-acetyltransferases. (R243)
1644,T3D0045,Pentachlorophenol,Choline O-acetyltransferase,P28329,Pentachlorophenol inhibits O-acetyltransferases. (R243)
1645,T3D0045,Pentachlorophenol,Lysophosphatidylcholine acyltransferase 2,Q7L5N7,Pentachlorophenol inhibits O-acetyltransferases. (R243)
1646,T3D0045,Pentachlorophenol,Thyroxine-binding globulin,P05543,"Pentachlorophenol causes adverse effects on thyroid homeostasis, decreasing serum thyroxine by competing for serum protein thyroxine binding sites. (R239)"
1647,T3D0045,Pentachlorophenol,1-acylglycerophosphocholine O-acyltransferase 1,Q8NF37,Pentachlorophenol inhibits O-acetyltransferases. (R243)
1648,T3D0045,Pentachlorophenol,Sodium/potassium-transporting ATPase gamma chain,P54710,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1649,T3D0045,Pentachlorophenol,Sodium/potassium-transporting ATPase alpha-1 chain,P05023,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1650,T3D0045,Pentachlorophenol,Sodium/potassium-transporting ATPase subunit alpha-2,P50993,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1651,T3D0045,Pentachlorophenol,Sodium/potassium-transporting ATPase subunit alpha-3,P13637,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1652,T3D0045,Pentachlorophenol,Sodium/potassium-transporting ATPase subunit alpha-4,Q13733,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1653,T3D0045,Pentachlorophenol,Sodium/potassium-transporting ATPase subunit beta-1,P05026,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1654,T3D0045,Pentachlorophenol,Sodium/potassium-transporting ATPase subunit beta-2,P14415,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1655,T3D0045,Pentachlorophenol,Sodium/potassium-transporting ATPase subunit beta-3,P54709,"This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1656,T3D0045,Pentachlorophenol,Potassium-transporting ATPase alpha chain 1,P20648,"Pentachlorophenol inhibits mitochondrial ATP-ase activity, preventing the the formation of ATP and the release of energy to the cell from the breakdown of ATP to ADP. (R244)"
1657,T3D0045,Pentachlorophenol,Potassium-transporting ATPase alpha chain 2,P54707,"Pentachlorophenol inhibits mitochondrial ATP-ase activity, preventing the the formation of ATP and the release of energy to the cell from the breakdown of ATP to ADP. (R244)"
1658,T3D0045,Pentachlorophenol,Potassium-transporting ATPase subunit beta,P51164,"Pentachlorophenol inhibits mitochondrial ATP-ase activity, preventing the the formation of ATP and the release of energy to the cell from the breakdown of ATP to ADP. (R244)"
1659,T3D0047,Carbon tetrachloride,Cytochrome P450 2E1,P05181,"Metabolism of carbon tetrachloride by CYP2E1 may result in the destruction of the enzyme during the metabolic process, either by direct attack of radicals on the cytochrome(s) or highly localized lipid peroxidation resulting in detachment of P-450 proteins from the microsomal membranes. (R245)"
1664,T3D0037,Acrolein,"Succinate-semialdehyde dehydrogenase, mitochondrial",P51649,Acrolein inhibits aldehyde dehydrogenases. (R227)
1670,T3D0001,Arsenic,"Actin, alpha cardiac muscle 1",P68032,Arsenic binds to actin. (R053)
1671,T3D0001,Arsenic,"Actin, alpha skeletal muscle",P68133,Arsenic binds to actin. (R053)
1672,T3D0001,Arsenic,"Actin, aortic smooth muscle",P62736,Arsenic binds to actin. (R053)
1673,T3D0001,Arsenic,"Actin, gamma-enteric smooth muscle",P63267,Arsenic binds to actin. (R053)
1676,T3D0053,Nickel,Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform,Q08209,"Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. (R100)"
1677,T3D0053,Nickel,Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform,P16298,"Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. (R100)"
1678,T3D0053,Nickel,Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform,P48454,"Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. (R100)"
1679,T3D0049,Cobalt,Carbonic anhydrase 2,P00918,"Cobalt inhibits carbonic anhydrases.(R086, R248)"
1680,T3D0049,Cobalt,Carbonic anhydrase 4,P22748,"Cobalt inhibits carbonic anhydrases.(R086, R248)"
1681,T3D0028,Cyanide,"Cytochrome c oxidase subunit 7A3, mitochondrial",O60397,"Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)"
1682,T3D0028,Cyanide,Probable glutathione peroxidase 8,Q8TED1 ,Cyanide inhibits glutathione peroxidases. (R212) 
1683,T3D0028,Cyanide,Extracellular superoxide dismutase [Cu-Zn],P08294,Cyanide inhibits superoxide dismutase [Cu-Zn]. (R209)
1684,T3D0017,Dieldrin,Gamma-aminobutyric acid receptor subunit epsilon,P78334,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1685,T3D0024,Aldrin,Gamma-aminobutyric acid receptor subunit epsilon,P78334,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1686,T3D0031,Toxaphene,Gamma-aminobutyric acid receptor subunit epsilon,P78334,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1687,T3D0032,"Hexachlorocyclohexane, gamma-",Gamma-aminobutyric acid receptor subunit epsilon,P78334,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1688,T3D0034,Heptachlor,Gamma-aminobutyric acid receptor subunit epsilon,P78334,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1689,T3D0036,"Hexachlorocyclohexane, beta-",Gamma-aminobutyric acid receptor subunit epsilon,P78334,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1690,T3D0041,Endrin,Gamma-aminobutyric acid receptor subunit epsilon,P78334,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1691,T3D0043,"Hexachlorocyclohexane, delta-",Gamma-aminobutyric acid receptor subunit epsilon,P78334,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1692,T3D0046,Heptachlor epoxide,Gamma-aminobutyric acid receptor subunit epsilon,P78334,"This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (R029)"
1693,T3D0054,Endosulfan,Gamma-aminobutyric acid receptor subunit epsilon,P78334,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1694,T3D0055,Endosulfan sulfate,Gamma-aminobutyric acid receptor subunit epsilon,P78334,"Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1695,T3D0057,"Endosulfan, alpha",Gamma-aminobutyric acid receptor subunit epsilon,P78334,"Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. (R194)"
1696,T3D0037,Acrolein,NF-kappa-B essential modulator,Q9Y6K9,"Perturbation of inflammatory responses in bronchial epithelial cells was demonstrated by direct action of acrolein on the inhibitor of nuclear factor kappa-B (IκB) kinase, which inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor and suppresses interleukin 8 (IL-8) production. (R223)"
1697,T3D0053,Nickel,Protamine-3,Q9NNZ6,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1698,T3D0053,Nickel,Sperm protamine-P1,P04553,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1700,T3D0082,"2,4,6-Trinitrotoluene","Nitric-oxide synthase, endothelial",P29474,"2,4,6-Trinitrotoluene is a competitive inhibitor with respect to NADPH and a noncompetitive inhibitor with respect to l-arginine. It binds to the P450 reductase domain of endothelial nitric oxide synthase and suppresses l-citrulline formation by shunting electrons away from the normal catalytic pathway. (R296)"
1702,T3D0001,Arsenic,Tubulin alpha chain-like 3,A6NHL2,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1703,T3D0001,Arsenic,Tubulin beta-8 chain B,A6NNZ2,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1706,T3D0006,Benzene,Tubulin alpha chain-like 3,A6NHL2,Direct binding of tubulin leads to protein damage. (R016)
1707,T3D0006,Benzene,Tubulin beta-8 chain B,A6NNZ2,Direct binding of tubulin leads to protein damage. (R016)
1708,T3D0045,Pentachlorophenol,X/potassium-transporting ATPase subunit beta-m,Q9UN42,"Pentachlorophenol inhibits mitochondrial ATP-ase activity, preventing the the formation of ATP and the release of energy to the cell from the breakdown of ATP to ADP. (R244)"
1709,T3D0004,Vinyl chloride,Ig gamma-1 chain C region,P01857,"Vinyl chloride poisoning exhibits many of the characteristics of autoimmune diseases. This is believed to be the result of a reactive vinyl chloride intermediate metabolite binding to an immunoglobulin G (IgG), altering the protein and initiating an immune response. (R010)"
1710,T3D0004,Vinyl chloride,Ig gamma-2 chain C region,P01859,"Vinyl chloride poisoning exhibits many of the characteristics of autoimmune diseases. This is believed to be the result of a reactive vinyl chloride intermediate metabolite binding to an immunoglobulin G (IgG), altering the protein and initiating an immune response. (R010)"
1711,T3D0004,Vinyl chloride,Ig gamma-3 chain C region,P01860,"Vinyl chloride poisoning exhibits many of the characteristics of autoimmune diseases. This is believed to be the result of a reactive vinyl chloride intermediate metabolite binding to an immunoglobulin G (IgG), altering the protein and initiating an immune response. (R010)"
1712,T3D0004,Vinyl chloride,Ig gamma-4 chain C region,P01861,"Vinyl chloride poisoning exhibits many of the characteristics of autoimmune diseases. This is believed to be the result of a reactive vinyl chloride intermediate metabolite binding to an immunoglobulin G (IgG), altering the protein and initiating an immune response. (R010)"
1713,T3D0012,"DDT, P,P'-",Sodium channel protein type 1 subunit alpha,P35498,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1714,T3D0012,"DDT, P,P'-",Sodium channel protein type 10 subunit alpha,Q9Y5Y9,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1715,T3D0012,"DDT, P,P'-",Sodium channel protein type 11 subunit alpha,Q9UI33,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1716,T3D0012,"DDT, P,P'-",Sodium channel protein type 2 subunit alpha,Q99250,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1717,T3D0012,"DDT, P,P'-",Sodium channel protein type 3 subunit alpha,Q9NY46,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1718,T3D0012,"DDT, P,P'-",Sodium channel protein type 4 subunit alpha,P35499,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1719,T3D0012,"DDT, P,P'-",Sodium channel protein type 7 subunit alpha,Q01118,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1720,T3D0012,"DDT, P,P'-",Sodium channel protein type 8 subunit alpha,Q9UQD0,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1721,T3D0012,"DDT, P,P'-",Sodium channel protein type 5 subunit alpha,Q14524,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1722,T3D0012,"DDT, P,P'-",Sodium channel protein type 9 subunit alpha,Q15858,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1723,T3D0061,Methoxychlor,Sodium channel protein type 1 subunit alpha,P35498,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1724,T3D0061,Methoxychlor,Sodium channel protein type 10 subunit alpha,Q9Y5Y9,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1725,T3D0061,Methoxychlor,Sodium channel protein type 11 subunit alpha,Q9UI33,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1726,T3D0061,Methoxychlor,Sodium channel protein type 2 subunit alpha,Q99250,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1727,T3D0061,Methoxychlor,Sodium channel protein type 3 subunit alpha,Q9NY46,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1728,T3D0061,Methoxychlor,Sodium channel protein type 4 subunit alpha,P35499,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1729,T3D0061,Methoxychlor,Sodium channel protein type 5 subunit alpha,Q14524,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1730,T3D0061,Methoxychlor,Sodium channel protein type 7 subunit alpha,Q01118,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1731,T3D0061,Methoxychlor,Sodium channel protein type 8 subunit alpha,Q9UQD0,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1732,T3D0061,Methoxychlor,Sodium channel protein type 9 subunit alpha,Q15858,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1733,T3D0021,"DDE, P,P'-",Sodium channel protein type 1 subunit alpha,P35498,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1734,T3D0021,"DDE, P,P'-",Sodium channel protein type 10 subunit alpha,Q9Y5Y9,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1735,T3D0021,"DDE, P,P'-",Sodium channel protein type 11 subunit alpha,Q9UI33,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1736,T3D0021,"DDE, P,P'-",Sodium channel protein type 2 subunit alpha,Q99250,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1737,T3D0021,"DDE, P,P'-",Sodium channel protein type 3 subunit alpha,Q9NY46,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1738,T3D0021,"DDE, P,P'-",Sodium channel protein type 4 subunit alpha,P35499,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1739,T3D0021,"DDE, P,P'-",Sodium channel protein type 5 subunit alpha,Q14524,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1740,T3D0021,"DDE, P,P'-",Sodium channel protein type 7 subunit alpha,Q01118,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1741,T3D0021,"DDE, P,P'-",Sodium channel protein type 8 subunit alpha,Q9UQD0,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1742,T3D0021,"DDE, P,P'-",Sodium channel protein type 9 subunit alpha,Q15858,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1743,T3D0025,"DDD, P,P'-",Sodium channel protein type 1 subunit alpha,P35498,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1744,T3D0025,"DDD, P,P'-",Sodium channel protein type 10 subunit alpha,Q9Y5Y9,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1745,T3D0025,"DDD, P,P'-",Sodium channel protein type 11 subunit alpha,Q9UI33,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1746,T3D0025,"DDD, P,P'-",Sodium channel protein type 2 subunit alpha,Q99250,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1747,T3D0025,"DDD, P,P'-",Sodium channel protein type 3 subunit alpha,Q9NY46,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1748,T3D0025,"DDD, P,P'-",Sodium channel protein type 4 subunit alpha,P35499,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1749,T3D0025,"DDD, P,P'-",Sodium channel protein type 5 subunit alpha,Q14524,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1750,T3D0025,"DDD, P,P'-",Sodium channel protein type 7 subunit alpha,Q01118,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1751,T3D0025,"DDD, P,P'-",Sodium channel protein type 8 subunit alpha,Q9UQD0,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1752,T3D0025,"DDD, P,P'-",Sodium channel protein type 9 subunit alpha,Q15858,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1753,T3D0001,Arsenic,Putative tubulin beta chain-like protein ENSP00000290377,A6NKZ8 ,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1754,T3D0001,Arsenic,Putative tubulin beta-4q chain,Q99867,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1755,T3D0001,Arsenic,Putative tubulin-like protein alpha-4B,Q9H853,"Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)"
1759,T3D0006,Benzene,Putative tubulin beta chain-like protein ENSP00000290377,A6NKZ8 ,Direct binding of tubulin leads to protein damage. (R016)
1760,T3D0006,Benzene,Putative tubulin beta-4q chain,Q99867,Direct binding of tubulin leads to protein damage. (R016)
1761,T3D0006,Benzene,Putative tubulin-like protein alpha-4B,Q9H853,Direct binding of tubulin leads to protein damage. (R016)
1762,T3D0049,Cobalt,Voltage-dependent L-type calcium channel subunit alpha-1C,Q13936,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1763,T3D0049,Cobalt,Ig epsilon chain C region,P01854,"Cobalt interacts with specific IgE antibodies, resulting in immunosensitization. (R254)"
1764,T3D0049,Cobalt,Ig alpha-2 chain C region,P01877,"Cobalt interacts with specific IgA antibodies, resulting in immunosensitization. (R255)"
1765,T3D0049,Cobalt,Ig alpha-1 chain C region,P01876,"Cobalt interacts with specific IgA antibodies, resulting in immunosensitization. (R255)"
1766,T3D0049,Cobalt,DNA repair protein complementing XP-A cells,P23025,Cobalt inhibits DNA repair by interacting with zinc finger DNA repair proteins. (R256)
1767,T3D0049,Cobalt,Poly [ADP-ribose] polymerase 1,P09874,Cobalt inhibits DNA repair by interacting with zinc finger DNA repair proteins. (R256)
1768,T3D0049,Cobalt,"5-aminolevulinate synthase, erythroid-specific, mitochondrial",P22557,Cobalt inhibits heme synthesis by preventing synthesis of 5-aminolaevulinate via inhibition of 5-aminolaevulinate synthase. (R057)
1769,T3D0049,Cobalt,"5-aminolevulinate synthase, nonspecific, mitochondrial",P13196,Cobalt inhibits heme synthesis by preventing synthesis of 5-aminolaevulinate via inhibition of 5-aminolaevulinate synthase. (R057)
1770,T3D0049,Cobalt,Voltage-dependent calcium channel gamma-1 subunit,Q06432,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1771,T3D0049,Cobalt,Voltage-dependent calcium channel gamma-2 subunit,Q9Y698,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1772,T3D0049,Cobalt,Voltage-dependent calcium channel gamma-3 subunit,O60359,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1773,T3D0049,Cobalt,Voltage-dependent calcium channel gamma-4 subunit,Q9UBN1,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1774,T3D0049,Cobalt,Voltage-dependent calcium channel gamma-5 subunit,Q9UF02,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1775,T3D0049,Cobalt,Voltage-dependent calcium channel gamma-6 subunit,Q9BXT2,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1776,T3D0049,Cobalt,Voltage-dependent calcium channel gamma-7 subunit,P62955,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1777,T3D0049,Cobalt,Voltage-dependent calcium channel gamma-8 subunit,Q8WXS5,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1778,T3D0049,Cobalt,Voltage-dependent calcium channel gamma-like subunit,Q8WXS4,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1779,T3D0049,Cobalt,Voltage-dependent calcium channel subunit alpha-2/delta-1,P54289,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1780,T3D0049,Cobalt,"Calcium channel, alpha 2/delta subunit 2",Q9NY47,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1781,T3D0049,Cobalt,Voltage-dependent calcium channel subunit alpha-2/delta-3,Q8IZS8,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1782,T3D0049,Cobalt,Voltage-dependent calcium channel subunit alpha-2/delta-4,Q7Z3S7,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1783,T3D0049,Cobalt,Voltage-dependent L-type calcium channel subunit alpha-1D,Q01668,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1784,T3D0049,Cobalt,Voltage-dependent L-type calcium channel subunit alpha-1F,O60840,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1785,T3D0049,Cobalt,Voltage-dependent L-type calcium channel subunit alpha-1S,Q13698,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1786,T3D0049,Cobalt,Voltage-dependent L-type calcium channel subunit beta-1,Q02641,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1787,T3D0049,Cobalt,Voltage-dependent L-type calcium channel subunit beta-2,Q08289,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1788,T3D0049,Cobalt,Voltage-dependent L-type calcium channel subunit beta-3,P54284,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1789,T3D0049,Cobalt,Voltage-dependent L-type calcium channel subunit beta-4,O00305,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1790,T3D0049,Cobalt,Voltage-dependent N-type calcium channel subunit alpha-1B,Q00975,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1791,T3D0049,Cobalt,Voltage-dependent P/Q-type calcium channel subunit alpha-1A,O00555,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1792,T3D0049,Cobalt,Voltage-dependent R-type calcium channel subunit alpha-1E,Q15878,"Cobalt blocks high-voltage-activated calcium channels, possibly impairing neurotransmission. (R253)"
1793,T3D0053,Nickel,Histone H1.0,P07305,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1794,T3D0053,Nickel,Histone H1.1,Q02539,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1795,T3D0053,Nickel,Histone H1.2,P16403,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1796,T3D0053,Nickel,Histone H1.3,P16402,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1797,T3D0053,Nickel,Histone H1.4,P10412,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1798,T3D0053,Nickel,Histone H1.5,P16401,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1799,T3D0053,Nickel,Histone H1oo,Q8IZA3,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1800,T3D0053,Nickel,Histone H1t,P22492,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1801,T3D0053,Nickel,Histone H1x,Q92522,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1802,T3D0053,Nickel,Testis-specific H1 histone,Q75WM6,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1803,T3D0053,Nickel,Histone H2A type 1,P0C0S8,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1804,T3D0053,Nickel,Histone H2A type 1-A,Q96QV6,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1805,T3D0053,Nickel,Histone H2A type 1-B/E,P04908,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1806,T3D0053,Nickel,Histone H2A type 1-C,Q93077,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1807,T3D0053,Nickel,Histone H2A type 1-D,P20671,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1808,T3D0053,Nickel,Histone H2A type 1-H,Q96KK5,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1809,T3D0053,Nickel,Histone H2A type 1-J,Q99878,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1810,T3D0053,Nickel,Histone H2A type 2-A,Q6FI13,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1811,T3D0053,Nickel,Histone H2A type 2-B,Q8IUE6,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1812,T3D0053,Nickel,Histone H2A type 2-C,Q16777,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1813,T3D0053,Nickel,Histone H2A type 3,Q7L7L0,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1814,T3D0053,Nickel,Histone H2A-Bbd type 1,P0C5Y9,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1815,T3D0053,Nickel,Histone H2A-Bbd type 2/3,P0C5Z0,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1816,T3D0053,Nickel,Histone H2A.J,Q9BTM1,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1817,T3D0053,Nickel,Histone H2A.V,Q71UI9,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1818,T3D0053,Nickel,Histone H2A.x,P16104,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1819,T3D0053,Nickel,Histone H2A.Z,P0C0S5,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1820,T3D0053,Nickel,Histone H2B type 1-A,Q96A08,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1821,T3D0053,Nickel,Histone H2B type 1-B,P33778,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1822,T3D0053,Nickel,Histone H2B type 1-C/E/F/G/I,P62807,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1823,T3D0053,Nickel,Histone H2B type 1-D,P58876,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1824,T3D0053,Nickel,Histone H2B type 1-H,Q93079,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1825,T3D0053,Nickel,Histone H2B type 1-J,P06899,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1826,T3D0053,Nickel,Histone H2B type 1-K,O60814,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1827,T3D0053,Nickel,Histone H2B type 1-L,Q99880,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1828,T3D0053,Nickel,Histone H2B type 1-M,Q99879,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1829,T3D0053,Nickel,Histone H2B type 1-N,Q99877,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1830,T3D0053,Nickel,Histone H2B type 1-O,P23527,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1831,T3D0053,Nickel,Histone H2B type 2-E,Q16778,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1832,T3D0053,Nickel,Histone H2B type 2-F,Q5QNW6,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1833,T3D0053,Nickel,Histone H2B type 3-B,Q8N257,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1834,T3D0053,Nickel,Histone H2B type F-M,P0C1H6,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1835,T3D0053,Nickel,Histone H2B type F-S,P57053,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1836,T3D0053,Nickel,Histone H2B type W-T,Q7Z2G1,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1837,T3D0053,Nickel,Histone H3-like,Q6NXT2,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1838,T3D0053,Nickel,Histone H3-like centromeric protein A,P49450,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1839,T3D0053,Nickel,Histone H4-like protein type G,Q99525,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1840,T3D0053,Nickel,Putative histone H2B type 2-C ,Q6DN03	,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1841,T3D0053,Nickel,Putative histone H2B type 2-D,Q6DRA6,"Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (R098)"
1842,T3D0006,Benzene,Histone H1.0,P07305,Direct binding of histone leads to protein damage. (R016)
1843,T3D0006,Benzene,Histone H1.1,Q02539,Direct binding of histone leads to protein damage. (R016)
1844,T3D0006,Benzene,Histone H1.2,P16403,Direct binding of histone leads to protein damage. (R016)
1845,T3D0006,Benzene,Histone H1.3,P16402,Direct binding of histone leads to protein damage. (R016)
1846,T3D0006,Benzene,Histone H1.4,P10412,Direct binding of histone leads to protein damage. (R016)
1847,T3D0006,Benzene,Histone H1.5,P16401,Direct binding of histone leads to protein damage. (R016)
1848,T3D0006,Benzene,Histone H1oo,Q8IZA3,Direct binding of histone leads to protein damage. (R016)
1849,T3D0006,Benzene,Histone H1t,P22492,Direct binding of histone leads to protein damage. (R016)
1850,T3D0006,Benzene,Histone H1x,Q92522,Direct binding of histone leads to protein damage. (R016)
1851,T3D0006,Benzene,Histone H2A type 1,P0C0S8,Direct binding of histone leads to protein damage. (R016)
1852,T3D0006,Benzene,Histone H2A type 1-A,Q96QV6,Direct binding of histone leads to protein damage. (R016)
1853,T3D0006,Benzene,Histone H2A type 1-B/E,P04908,Direct binding of histone leads to protein damage. (R016)
1854,T3D0006,Benzene,Histone H2A type 1-C,Q93077,Direct binding of histone leads to protein damage. (R016)
1855,T3D0006,Benzene,Histone H2A type 1-D,P20671,Direct binding of histone leads to protein damage. (R016)
1856,T3D0006,Benzene,Histone H2A type 1-H,Q96KK5,Direct binding of histone leads to protein damage. (R016)
1857,T3D0006,Benzene,Histone H2A type 1-J,Q99878,Direct binding of histone leads to protein damage. (R016)
1858,T3D0006,Benzene,Histone H2B type 1-K,O60814,Direct binding of histone leads to protein damage. (R016)
1859,T3D0006,Benzene,Histone H2A type 2-A,Q6FI13,Direct binding of histone leads to protein damage. (R016)
1860,T3D0006,Benzene,Histone H2A type 2-B,Q8IUE6,Direct binding of histone leads to protein damage. (R016)
1861,T3D0006,Benzene,Histone H2A type 2-C,Q16777,Direct binding of histone leads to protein damage. (R016)
1862,T3D0006,Benzene,Histone H2A type 3,Q7L7L0,Direct binding of histone leads to protein damage. (R016)
1863,T3D0006,Benzene,Histone H2A-Bbd type 1,P0C5Y9,Direct binding of histone leads to protein damage. (R016)
1864,T3D0006,Benzene,Histone H2A-Bbd type 2/3,P0C5Z0,Direct binding of histone leads to protein damage. (R016)
1865,T3D0006,Benzene,Histone H2A.J,Q9BTM1,Direct binding of histone leads to protein damage. (R016)
1866,T3D0006,Benzene,Histone H2A.V,Q71UI9,Direct binding of histone leads to protein damage. (R016)
1867,T3D0006,Benzene,Histone H2A.x,P16104,Direct binding of histone leads to protein damage. (R016)
1868,T3D0006,Benzene,Histone H2A.Z,P0C0S5,Direct binding of histone leads to protein damage. (R016)
1869,T3D0006,Benzene,Histone H2B type 1-A,Q96A08,Direct binding of histone leads to protein damage. (R016)
1870,T3D0006,Benzene,Histone H2B type 1-B,P33778,Direct binding of histone leads to protein damage. (R016)
1871,T3D0006,Benzene,Histone H2B type 1-C/E/F/G/I,P62807,Direct binding of histone leads to protein damage. (R016)
1872,T3D0006,Benzene,Histone H2B type 1-D,P58876,Direct binding of histone leads to protein damage. (R016)
1873,T3D0006,Benzene,Histone H2B type 1-H,Q93079,Direct binding of histone leads to protein damage. (R016)
1874,T3D0006,Benzene,Histone H2B type 1-J,P06899,Direct binding of histone leads to protein damage. (R016)
1875,T3D0006,Benzene,Histone H2B type 1-L,Q99880,Direct binding of histone leads to protein damage. (R016)
1876,T3D0006,Benzene,Histone H2B type 1-M,Q99879,Direct binding of histone leads to protein damage. (R016)
1877,T3D0006,Benzene,Histone H2B type 1-N,Q99877,Direct binding of histone leads to protein damage. (R016)
1878,T3D0006,Benzene,Histone H2B type 1-O,P23527,Direct binding of histone leads to protein damage. (R016)
1879,T3D0006,Benzene,Histone H2B type 2-E,Q16778,Direct binding of histone leads to protein damage. (R016)
1880,T3D0006,Benzene,Histone H2B type 2-F,Q5QNW6,Direct binding of histone leads to protein damage. (R016)
1881,T3D0006,Benzene,Histone H2B type 3-B,Q8N257,Direct binding of histone leads to protein damage. (R016)
1882,T3D0006,Benzene,Histone H2B type F-M,P0C1H6,Direct binding of histone leads to protein damage. (R016)
1883,T3D0006,Benzene,Histone H2B type F-S,P57053,Direct binding of histone leads to protein damage. (R016)
1884,T3D0006,Benzene,Histone H2B type W-T,Q7Z2G1,Direct binding of histone leads to protein damage. (R016)
1885,T3D0006,Benzene,Histone H3-like,Q6NXT2,Direct binding of histone leads to protein damage. (R016)
1886,T3D0006,Benzene,Histone H3-like centromeric protein A,P49450,Direct binding of histone leads to protein damage. (R016)
1887,T3D0006,Benzene,Histone H4-like protein type G,Q99525,Direct binding of histone leads to protein damage. (R016)
1888,T3D0006,Benzene,Testis-specific H1 histone,Q75WM6,Direct binding of histone leads to protein damage. (R016)
1889,T3D0006,Benzene,Putative histone H2B type 2-C ,Q6DN03	,Direct binding of histone leads to protein damage. (R016)
1890,T3D0006,Benzene,Putative histone H2B type 2-D,Q6DRA6,Direct binding of histone leads to protein damage. (R016)
1891,T3D0050,"DDT, O,P'-",Sodium channel protein type 1 subunit alpha,P35498,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1892,T3D0050,"DDT, O,P'-",Sodium channel protein type 10 subunit alpha,Q9Y5Y9,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1893,T3D0050,"DDT, O,P'-",Sodium channel protein type 11 subunit alpha,Q9UI33,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1894,T3D0050,"DDT, O,P'-",Sodium channel protein type 2 subunit alpha,Q99250,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1895,T3D0050,"DDT, O,P'-",Sodium channel protein type 3 subunit alpha,Q9NY46,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1896,T3D0050,"DDT, O,P'-",Sodium channel protein type 4 subunit alpha,P35499,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1897,T3D0050,"DDT, O,P'-",Sodium channel protein type 5 subunit alpha,Q14524,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1898,T3D0050,"DDT, O,P'-",Sodium channel protein type 7 subunit alpha,Q01118,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1899,T3D0050,"DDT, O,P'-",Sodium channel protein type 8 subunit alpha,Q9UQD0,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1900,T3D0050,"DDT, O,P'-",Sodium channel protein type 9 subunit alpha,Q15858,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1901,T3D0050,"DDT, O,P'-",Sodium channel subunit beta-1,Q07699,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1902,T3D0050,"DDT, O,P'-",Sodium channel subunit beta-2,O60939,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1903,T3D0050,"DDT, O,P'-",Sodium channel subunit beta-3,Q9NY72,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1904,T3D0050,"DDT, O,P'-",Sodium channel subunit beta-4,Q8IWT1,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1905,T3D0012,"DDT, P,P'-",Sodium channel subunit beta-1,Q07699,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1906,T3D0012,"DDT, P,P'-",Sodium channel subunit beta-2,O60939,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1907,T3D0012,"DDT, P,P'-",Sodium channel subunit beta-3,Q9NY72,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1908,T3D0012,"DDT, P,P'-",Sodium channel subunit beta-4,Q8IWT1,"DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1909,T3D0021,"DDE, P,P'-",Sodium channel subunit beta-1,Q07699,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1910,T3D0021,"DDE, P,P'-",Sodium channel subunit beta-2,O60939,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1911,T3D0021,"DDE, P,P'-",Sodium channel subunit beta-3,Q9NY72,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1912,T3D0021,"DDE, P,P'-",Sodium channel subunit beta-4,Q8IWT1,"DDE inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1913,T3D0025,"DDD, P,P'-",Sodium channel subunit beta-1,Q07699,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1914,T3D0025,"DDD, P,P'-",Sodium channel subunit beta-2,O60939,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1915,T3D0025,"DDD, P,P'-",Sodium channel subunit beta-3,Q9NY72,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1916,T3D0025,"DDD, P,P'-",Sodium channel subunit beta-4,Q8IWT1,"DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (R252)"
1917,T3D0061,Methoxychlor,Sodium channel subunit beta-1,Q07699,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1918,T3D0061,Methoxychlor,Sodium channel subunit beta-2,O60939,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1919,T3D0061,Methoxychlor,Sodium channel subunit beta-3,Q9NY72,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1920,T3D0061,Methoxychlor,Sodium channel subunit beta-4,Q8IWT1,"As methoxychlor is also a structural analogue of DDT, it is believed to have the same neurotoxic effects. This includes preventing the deactivation of the sodium gate after neuron activation and membrane depolarization, resulting in hyperexcitability of the nerve. (R029, R323)"
1921,T3D0052,Di-n-butyl phthalate,"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial",Q99643,Di-n-butyl phthalate has been shown to exhibit toxic effects in liver mitochondria by uncoupling energy-linked processes and inhibiting succinate dehydrogenase. (R259)
1922,T3D0052,Di-n-butyl phthalate,"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial",O14521,Di-n-butyl phthalate has been shown to exhibit toxic effects in liver mitochondria by uncoupling energy-linked processes and inhibiting succinate dehydrogenase. (R259)
1923,T3D0052,Di-n-butyl phthalate,"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",P31040,Di-n-butyl phthalate has been shown to exhibit toxic effects in liver mitochondria by uncoupling energy-linked processes and inhibiting succinate dehydrogenase. (R259)
1924,T3D0052,Di-n-butyl phthalate,"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial",P21912,Di-n-butyl phthalate has been shown to exhibit toxic effects in liver mitochondria by uncoupling energy-linked processes and inhibiting succinate dehydrogenase. (R259)
1925,T3D0052,Di-n-butyl phthalate,Peroxisome proliferator-activated receptor alpha,Q07869,"Di-n-butyl phthalate causes peroxisome proliferation by activating peroxisome proliferator-activated receptors, which may lead to carcinogenic effects. (R262)"
1926,T3D0052,Di-n-butyl phthalate,Peroxisome proliferator-activated receptor gamma,P37231,"Di-n-butyl phthalate causes peroxisome proliferation by activating peroxisome proliferator-activated receptors, which may lead to carcinogenic effects. (R262)"
1928,T3D0770,Ethanol,Cytochrome P450 2E1,P05181,"Ethanol binds to the ubiquitination site of CYP2E1. Ethanol binds to the enzyme and blocks access to the ubiquitination site by the ubiquitin conjugating system. The ubiquitin binding site is at the substrate binding site of the CYP2E1 enzyme, thus preventing ubiquitin from binding at that site. (R267)"
1929,T3D0053,Nickel,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3,Q96Q83,"Nickel substitutes for iron in alpha-ketoglutarate-dependent dioxygenases, inhibiting DNA repair. (R295)"
1930,T3D0053,Nickel,JmjC domain-containing histone demethylation protein 3A,O75164,"Nickel substitutes for iron in jmjC domain-containing histone demethylation proteins, inhibiting their demethylation activity. (R295)"
1932,T3D0053,Nickel,Egl nine homolog 2,Q96KS0,"Nickel substitutes for iron in hypoxia-inducible factor prolyl hydroxylases, inhibiting their enzyme activity. This results in the accumulation of hypoxia inducible factor 1 alpha, causing hypoxia-mimic stress. (R295)"
1933,T3D0053,Nickel,JmjC domain-containing histone demethylation protein 2A,Q9Y4C1,"Nickel substitutes for iron in jmjC domain-containing histone demethylation proteins, inhibiting their demethylation activity. (R295)"
1934,T3D0053,Nickel,Egl nine homolog 1,Q9GZT9,"Nickel substitutes for iron in hypoxia-inducible factor prolyl hydroxylases, inhibiting their enzyme activity. This results in the accumulation of hypoxia inducible factor 1 alpha, causing hypoxia-mimic stress. (R295)"
1935,T3D0053,Nickel,Egl nine homolog 3,Q9H6Z9,"Nickel substitutes for iron in hypoxia-inducible factor prolyl hydroxylases, inhibiting their enzyme activity. This results in the accumulation of hypoxia inducible factor 1 alpha, causing hypoxia-mimic stress. (R295)"
1936,T3D0053,Nickel,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2,Q6NS38,"Nickel substitutes for iron in alpha-ketoglutarate-dependent dioxygenases, inhibiting DNA repair. (R295)"
1938,T3D0085,"1,2-Dichloroethane",Protein disulfide-isomerase,P07237,"S-(2-chloroethyl)glutathione, one of the glutathione conjugates of 1,2-dichloroethane, is known to irreversibly inhibit protein disulfide-isomerase via alkylation. (R374)"
1939,T3D0056,Diazinon,Acetylcholinesterase,P22303,"Diazoxon the main toxic intermediate of diazinon, inhibits acetylcholinesterase in the central and peripheral nervous system. This results in the accumulation of acetylcholine, causing excessive stimulation of cholinergic fibers in the postganglionic parasympathetic nerve endings, neuromuscular junctions of the skeletal muscles, and cells of the central nervous system that results in hyperpolarization and receptor desensitization. This produces muscarinic, nicotinic, and CNS effects. (R313)"
1940,T3D0056,Diazinon,Probable arylformamidase,Q63HM1,Diazoxon inhibits liver kynurenine formamidase. (R317)
1941,T3D0086,"2,4,6-Trichlorophenol",Acetylcholinesterase,P22303,"2,4,6-trichlorophenol (2,4,6-TCP) has been identified to hemolyze washed human erythrocytes and inhibit acetylcholinesterase (AchE) activities in the erythrocyte membrane. (R318)"
1942,T3D0058,Xylene,Cytochrome P450 2E1,P05181,Certain metabolites of xylene have been shown to inhibit pulmonary mixed-function oxidases. (R322)
1943,T3D0058,Xylene,Cytochrome P450 4B1,P13584,Certain metabolites of xylene have been shown to inhibit pulmonary mixed-function oxidases. (R322)
1944,T3D0059,"Chlordane, cis-","Alkaline phosphatase, tissue-nonspecific isozyme",P05186,Chlordane inhibit alkaline phosphatases in hepatic and renal tissues. (R206)
1947,T3D0059,"Chlordane, cis-",Cytochrome P450 2B6,P20813,"Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (R159, R205)"
1948,T3D0059,"Chlordane, cis-",Cytochrome P450 3A4,P08684,"Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (R159, R205)"
1949,T3D0059,"Chlordane, cis-",Cytochrome P450 3A43,Q9HB55,"Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (R159, R205)"
1950,T3D0059,"Chlordane, cis-",Cytochrome P450 3A5,P20815,"Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (R159, R205)"
1951,T3D0059,"Chlordane, cis-",Cytochrome P450 3A7,P24462,"Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (R159, R205)"
1952,T3D0059,"Chlordane, cis-",Estrogen-related receptor gamma,P62508,Chlordane affects transcription by antagonizing estrogen-related receptors. (R162)
1954,T3D0059,"Chlordane, cis-",Retinoic acid receptor beta,P10826,"Chlordane has been shown to bind and activate retinoic acid receptor, causing various developmental defects. (R163)"
1955,T3D0059,"Chlordane, cis-",Retinoic acid receptor gamma-1,P13631,"Chlordane has been shown to bind and activate retinoic acid receptor, causing various developmental defects. (R163)"
1956,T3D0059,"Chlordane, cis-",Steroid hormone receptor ERR1,P11474,Chlordane affects transcription by antagonizing estrogen-related receptors. (R162) 
1957,T3D0059,"Chlordane, cis-",Steroid hormone receptor ERR2,O95718,Chlordane affects transcription by antagonizing estrogen-related receptors. (R162) 
1958,T3D0060,Dibromochloropropane,"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial",P49821,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1959,T3D0060,Dibromochloropropane,"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial",P19404,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1960,T3D0060,Dibromochloropropane,"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial",P56181,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1961,T3D0060,Dibromochloropropane,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial",O75306,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1962,T3D0060,Dibromochloropropane,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial",O75489,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1963,T3D0060,Dibromochloropropane,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial",O43181,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1964,T3D0060,Dibromochloropropane,NADH dehydrogenase [ubiquinone] iron-sulfur protein 5,O43920,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1965,T3D0060,Dibromochloropropane,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial",O75380,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1966,T3D0060,Dibromochloropropane,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial",O75251,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1967,T3D0060,Dibromochloropropane,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial",O00217,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1968,T3D0060,Dibromochloropropane,"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial",P28331,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1970,T3D0060,Dibromochloropropane,NADH-ubiquinone oxidoreductase chain 2,P03891,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1971,T3D0060,Dibromochloropropane,NADH-ubiquinone oxidoreductase chain 3,P03897,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1972,T3D0060,Dibromochloropropane,NADH-ubiquinone oxidoreductase chain 4,P03905,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1973,T3D0060,Dibromochloropropane,NADH-ubiquinone oxidoreductase chain 4L,P03901,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1974,T3D0060,Dibromochloropropane,NADH-ubiquinone oxidoreductase chain 5,P03915,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1975,T3D0060,Dibromochloropropane,NADH-ubiquinone oxidoreductase chain 6,P03923,"Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)"
1976,T3D0061,Methoxychlor,Estrogen receptor,P03372,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
1977,T3D0061,Methoxychlor,Estrogen receptor beta,Q92731,Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
1978,T3D0061,Methoxychlor,Androgen receptor,P10275,"Certain mono- and bis-hydroxy metabolites of methoxychlor, especially 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane (HPTE), act as estrogen analogues. HPTE is an know androgen receptor antagonist. (R325)"
1979,T3D0063,Endrin ketone,Calcium-transporting ATPase type 2C member 1,P98194,"Endrin inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1980,T3D0069,Endrin aldehyde,Calcium-transporting ATPase type 2C member 1,P98194,"Endrin inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1981,T3D0063,Endrin ketone,Calcium-transporting ATPase type 2C member 2,O75185,"Endrin inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (R029)"
1982,T3D0069,Endrin aldehyde,Calcium-transporting ATPase type 2C member 2,O75185,"Endrin inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accum